Respiratory Telemetry in Large Species
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Transcript of Respiratory Telemetry in Large Species
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Rat Dual Pressure Telemetry 1
Respiratory Telemetry in
Large Species
Recording Respiratory Data, BP and ECG
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CorDynamics introduces telemetry that records respiratory
parameters along with blood pressure and ECG in large animals
Multiple options
1) blood pressure, ECG, and respiratory parameters
- simultaneous and continuous recording
- combines two ICH S7 assessments in one study
2) can be used in multiple species
- rabbit, dog, pig, NHP
Pharmacological validation
- bethanechol (cholinergic agonist)
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Effects of bethanechol on heart rate
0
50
100
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200
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300
350
-70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490
HR
(b
pm
)
Time (minutes)
Effect of Bethanechol (subcutaneous) on Heart Ratein the Conscious, Telemetrized Rabbit
Vehicle (n=4)
10 mg/kg (n=4)
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Effects of bethanechol on tidal volume
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5
10
15
20
25
30
-70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490
TV
(m
l)
Time (minutes)
Effect of Bethanechol (subcutaneous) on Tidal Volumein the Conscious, Telemetrized Rabbit
Vehicle (n=4)
10 mg/kg (n=4)
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Effects of bethanechol on minute volume
0
500
1000
1500
2000
2500
3000
3500
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MV
(m
l)
Time (minutes)
Effect of Bethanechol (subcutaneous) on Minute Volumein the Conscious, Telemetrized Rabbit
Vehicle (n=4)
10 mg/kg (n=4)
![Page 6: Respiratory Telemetry in Large Species](https://reader038.fdocuments.in/reader038/viewer/2022100606/559f60d91a28ab5e528b474e/html5/thumbnails/6.jpg)
Effects of bethanechol on respiratory rate
0
50
100
150
200
250
300
-70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490
Rf
(bre
ath
s/m
in)
Time (minutes)
Effect of Bethanechol (subcutaneous) on Respiratory Ratein the Conscious, Telemetrized Rabbit
Vehicle (n=4)
10 mg/kg (n=4)