Research & reviews a journal of drug design & discovery (vol1, issue2)

Research & Reviews: A Journal of

Drug Design & DiscoveryRRJoDDD

May - August 2014

STM JOURNALSScientific Technical Medical

eISSN: 2349-9036

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Research & Reviews: A Journal of Drug Design & Discovery

eISSN: 2349-9036

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Industrial Tribology Machine Dynamics & Maintenance

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Indian Institute of Technology Delhi, India.

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Alternative Energy Technology Laboratory,

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Dr. Ashish RunthalaLecturer, Biological Sciences Group,

Birla Institute of Technology & Science, Pilani Rajasthan, India.

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Former Director, Indira Gandhi Centre for Atomic Research, India.

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Chandigarh, India.

STM Journal (s) Advisory Board & Editorial Board

Editorial Board

Dr. A Srinivasa RaoProfessor & HOD Dept. of Pharmaceutical

Analysis & QA Shri Vishnu College of Pharmacy Vishnupur, A.P,

India.

Dr. Amita VermaHead Dept. of Pharmaceutical Sciences,

SHIATS-Deemed University, Allahabad, India.

Dr. Arabinda NayakHOD, Department of Pharmacology, Gujarat Technological University,

India.

Dr. Deepika SinghMedical Chemistry Division

CSIR - Indian Institute of Integrative Medicine, Canal Road,

Jammu, India.

Dr. Anita MahapatraAssistant Professor, Dept. of Natural

Products NIPER, Ahmedabad, Gujarat, India.

Dr. Abhay DharamsiProfessor and Head Dept. of

Pharmaceutics Maliba Pharmacy College Bardoli-Mahuva Road,

Gujarat, India.

Dr. George D GeromichalosHead, Molecular Modeling & Drug

Design Symeonidion Research Center Theagenion Cancer Hospital,

Greece.

Dr. Jayarajakumar Kalaimani Faculty of Pharmacy, AIMST University,

Bedong, Malaysia.

Dr. K.K SivakumarAssistant Professor,

Department of Pharmaceutical Chemistry,KMCH College of Pharmacy,

Coimbatore, India.

Miss Maushmi Shailesh KumarAssistant Professor, Dept. of Pharmaceutical

Biotechnology, SPPSPTM, NMIMS University, Mumbai, India.

Dr Murugesan SankaranAssistant Professor, Department of

Pharmacy, Birla Institute of Technology, Pilani, Rajasthan, India.

Dr. Muthyala Murali Krishna KumarAssistant Professor, College of

Pharmaceutical Sciences, Andhra, India.

Editorial Board

Dr. Suneel .I. MajagiAssociate Professor

Department of PharmacologyJ.N.Medical College

Belgaum, Karnataka, India.

Mr. T Durai Ananda KumarSr Assistant Professor,

Dept of Pharmaceutical Chemistry,Gokaraju Rangaraju College of Pharmacy,

Nizampet, Hyderabad, India.

Dr. Udayabanu MalairamanAssistant Professor, Department of

Pharmacy, Jaypee University of Information Technology, Solan, H.P,

India.

Dr. V. RavichandranFaculty of Pharmacy, AIMST University,

Semeling, Kedah, Malaysia.

Dr. Jenifer Solomon Rajan Asst. Profesor, Department of

Biotechnology,Bon secours College for Womens, Thanjavur,

Tamilnadu, India.

Dr. Santanu ChakrabortyAssistant Professor, Department:

Pharmaceutics, Dr. B. C. Roy Engineering College, Kolkata, India.

Dr. Sandip Prabhakar Zine Assistant Professor, Department of

Pharmaceutical Chemistry, Vivekanand Education Society's College of Pharmacy,

Mumbai, India.

Dr. Nahlah Elkudsiah IsmailFaculty of Pharmacy, Universiti Teknologi

MARA (UiTM) Puncak Alam Campus, Bandar Puncak Alam, Selangor,

Malaysia.

Dr. Mudit DixitHead-Department of Drug Regulatory

Affairs & Assistant Professor (Pharmaceutics)(Senior Grade), NGSM

Institute of Pharmaceutical Sciences, Mangalore, India.

Dr. Shihabuddin Bin AhmadSenior Lecturer Faculty of Pharmacy, Universiti Teknologi MARA, Puncak

Alam, Selangor, Malaysia.

Ms. Soh Yee ChangFaculty of Pharmacy

UiTM Puncak Alam CampusMalaysia.

Editorial Board

Dr. Nishant ShuklaLecturer Head of Kayachikitsa ,Coordinatordaivyavyapashrya

chikitsa Kendra, India.

Dr. Poonam SinghScientist CSIR-Central Drug Research

Institute, Lucknow, India.

Mrs. Priti JainDept. of Pharmacy, Birla Institute of

Technology and Science, Pilani, India.

Dr. R.K SinghSenior Principal Scientist, CDRI,

Lucknow, India.

Dr. Pratap Chandra AcharyaAssistant Professor, Dept. of

Pharmaceutical Chemistry, SPPSPTM, SVKM'S NMIMS University, Mumbai,

India.

Dr. P. Senthil KumarAssistant Professor, KMCH College

of Pharmacy, Coimbatore, India.

Dr. Sadia SultanLecturer, Faculty of Pharmacy, UiTM Puncak Alam Campus Bandar Puncak

Alam Selangor, Malaysia.

Dr. Sanghapal D. SawantCSIR-Indian Institute of Integrative

Medicine, Jammu, India.

Dr. Sapna ShrikumarPrincipal, Moulana College of Pharmacy,

Angadtppuram , Perinthalmanna, Malappuram, Kerala, India.

Dr. Shashank K SinghSenior Scientist, CSIR-Indian Institute of Integrative Medicine ,Canal Road Jammu,

India.

I take the privilege to present the print version for the Volume 1 Issue (2) of Research & Reviews: A

Journal of Drug Design and Discovery. The intension of RRJoDDD is to create an atmosphere that

stimulates creativeness, research and growth in the area of Drug Design and Discovery.

The development and growth of the mankind is the consequence of brilliant Research done by

eminent Scientists and Engineers in every field. RRJoDDD provides an outlet for Research findings

and reviews in areas of Drug Design and Discovery found to be relevant for National and

International recent developments & research initiative.

The aim and scope of the Journal is to provide an academic medium and an important reference for

the advancement and dissemination of Research results that support high level learning, teaching and

research in the domain of Drug Design and Discovery.

Finally, and Authors for their continued support and invaluable contributions and suggestions in the

form of authoring I express my sincere gratitude and thanks to our Editorial/ Reviewer board write

ups/ reviewing and providing constructive comments for the advancement of the journals. With

regards to their due continuous support and co-operation, we have been able to publish quality

Research/Reviews findings for our customers base.

I hope you will enjoy reading this issue and we welcome your feedback on any aspect of the Journal.

Dr. Archana Mehrotra

Director

STM Journals

Director's Desk

STM JOURNALS

1. Antibacterial Activity and Preliminary Phytochemical Screening of the Extracts of the Bark of Moringa oleifera Jenifer S, Priya S 1

2. Antibacterial Activity of Leaf and Flower Extract of Lablab purpureus against Clinical Isolates of Staphylococcus aureus Priya S., Jenifer S. 5

3. Single Nucleotide Polymorphism in CYP17 and CYP19 in Breast CancerLaveena D. K., Jenifer S., Singh S. J. S. 8

4. Pharmacology of Herbal Drugs: Ayurvedic ApproachNishant Shukla 12

5. A Comprehensive Literary Review on Heavenly Elixir–AmritaPatil Shilpa, Chaudhary Anandkumar 15

ContentsResearch & Reviews: A Journal of Drug Design & Discovery

RRJoDDD (2014)© STM Journals 2014. All Rights Reserved

Research & Reviews: A Journal of Drug Design & Discovery ISSN: 2349-9036 (online)

Volume 1, Issue 2

www.stmjournals.com

Antibacterial Activity and Preliminary Phytochemical

Screening of the Extracts of the Bark of Moringa oleifera

Jenifer S1*, Priya S

2

1Department of Biotechnology, Bon Secours College for Women, Thanjavur, Tamil Nadu, India

2Department of Biotechnology, S.T.E.T. Women’s College, Mannargudi, Tamil Nadu, India

Abstract Ethyl acetate, acetone, methanol and aqueous extracts of the bark Moringa oleifera were screened against the enteric pathogens isolates namely, Esherichia coli, Shigella sonnei

and Salmonella enteritis. All the extracts other than aqueous extract showed

antimicrobial activity with the methanol extract having the percentage of activity. Preliminary phytochemical screening revealed the presence of and tannins in the

methanol extract.

Keywords: Moringa oleifera, bark, antimicrobial activity, flavones, tannins



Volume 1, Issue 2

www.stmjournals.com

Antibacterial Activity of Leaf and Flower Extract of

Lablab purpureus against Clinical Isolates of

Staphylococcus aureus

Priya S.1, Jenifer S.

2* 1Department of Biotechnology, S.T.E.T. Women’s College, Mannargudi, Tamil Nadu, India

2Department of Biotechnology, Bon Secours College for Women’s, Thanjavur, Tamil Nadu, India

Abstract The present study was undertaken to determine inhibitory activity of leaf and flower

extracts of Lablab purpureus against clinical isolates of Staphylococcus aureus. Agar

well diffusion assay was performed to determine antibacterial activity. Among extracts, the flower extract has shown marked inhibition of S. aureus isolates. It can be concluded

that the leaf and flower extracts possess inhibitory components. The bioactive components present in the plant are to be separated and subjected for antibacterial

activity.

Keywords: Lablab purpureus, Staphylococcus aureus, agar well diffusion



Volume 1, Issue 2

www.stmjournals.com

Single Nucleotide Polymorphism in CYP17 and CYP19

in Breast Cancer

Laveena D. K.1, Jenifer S.

1*, Singh S. J. S.2

1Department of Biotechnology, Bon Secours College for Women’s, Thanjavur, TamilNadu, India

2Bishop Heber College Trichy, Tamilnadu, India

Abstract A single T > C change at the 5’ promoter region of the CYP17 and CYP19 genes are reported to be associated with increased risk of breast cancer. This study evaluates the

influence of genetic polymorphism of CYP17 and CYP19 on breast cancer susceptibility.

Ten patients with histopathologically confirmed breast cancer and 30 age-matched controls were included in study. A polymerase chain reaction – single nucleotide

polymorphism (PCR-SSCP) method was used to detect the polymorphism.

Keywords: CYP17 and CYP 19 subunits of Cytochrome 450, SSCP single strand

conformational polymorphism



Volume 1, Issue 2

www.stmjournals.com

Pharmacology of Herbal Drugs: Ayurvedic Approach

Nishant Shukla* PAMCH, Morjand Khari, Sri Ganganagar, Rajasthan, India

Abstract Herbal drugs are gaining acceptance globally. The present approach of studying them is

based on modern parameters. Most of these drugs are described in ancient Ayurvedic treatises and so Ayurvedic method of studying pharmacology is necessary. It is also nec-

essary to study pharmacokinetics as per Ayurveda only. The study of the herbs is to be done in following steps. The first step is to study fivefold properties of herb, i.e., Rasa

(taste), Guna (properties), Virya (potency), Vipak and Prabhava (specific action). The

second step is to know pharmacological effects as per time and route of administration. The third step is to know the role of vehicle and effect of combination of the drug. Details

will be presented in full paper.

Keywords: Herbal drugs, pharmacology, ayurvedic, herbs



Volume 1, Issue 2

www.stmjournals.com

A Comprehensive Literary Review on Heavenly

Elixir–Amrita

Patil Shilpa1*, Chaudhary Anandkumar

2

1Department of Agadtantra, Bhausaheb Mulik Ayurveda College, Nagpur, Maharashtra, India

2Department of Rasa Shastra, Faculty of Ayurveda, IMS, BHU, Varanasi, India

Abstract Tinospora cordifolia (Willd.) Hook. f. and Thoms. (Amrita) is the most researched drug since ancient time till contemporary era regarding its wide range of therapeutics. One

can witness several research papers published in indexed journal pioneering role of

Amrita in human health care. This review article is an attempt to concentrate purely on the classical contour and focusing on literary findings regarding the Amrita.

Keywords: Ayurveda, amrita, tinospora cordifolia, literary review

Research & reviews a journal of drug design & discovery (vol1, issue2)

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