RESEARCH INVESTIGACIÓN - Organización Sanitaria ... · RESEARCH INVESTIGACIÓN The Cruces...

RESEARCH INVESTIGACIÓN

The Cruces Hospital Research Unit (RU) was permanently accredited by the Health Care Research Fund (FIS) of the Ministry of Health and Consumer Affairs in 1993. It is made up of the Molecular Genetics Laboratory, a Pulmonary Physiopathology Laboratory, the Experimental Operating Theatre and Animal Facility, the Clinical Epidemiology Unit and the Clinical Studies Technical Secretariat. The level of our RU corresponds to that of a Clinical-Experimental Unit, which combines the structures and human resources to perform clinical-epidemiological research as well as basic applied research.

La Unidad de investigación (UI) del Hospital de Cruces fue acreditada de forma definitiva por el Fondo de Investigaciones Sanitarias (FIS) del Ministerio de Sanidad y Consumo en 1993. Está estructurada en un Laboratorio de Genética Molecular, un Laboratorio de Fisiopatología Pulmonar, el Quirófano Experimental con el Estabulario, la Unidad de Epidemiología Clínica y la Secretaría Técnica de Ensayos Clínicos. El nivel de nuestra UI corresponde al de una Unidad Clinico-Experimental, que combina estructuras y recursos humanos para realizar investigación clinico-epidemiológica y básica aplicada.

This RU performs research that is primarily financed by theFIS and the Basque Government´s Department of Health Care. Under the general coordination of BIOEF (Foundation for Health Care Innovation and Research), with OIKER (Health Care Research Institute) as one of its basic structures, our RU continues a process of consolidation and development, currently limited by the overall scarcity of space in the centre.

Dicha UI realiza investigación financiada fundamentalmente vía FIS y Departamento de Sanidad del Gobierno Vasco. Bajo la coordinación general de BIOEF (Fundación de Innovación e Investigación Sanitarias), con OIKER (Instituto de Investigaciones Sanitarias) como una de sus estructuras fundamentales, nuestra UI continúa en un proceso de consolidación y desarrollo, limitado actualmente por la escasez general de espacios en el centro.

The 2009 innovations to highlight include: Entre las novedades a destacar en este año 2009 incluimos: a) start of the hospital´s Central Unit for Clinical Research and Clinical Studies (UCICEC), belonging to CAIBER (Support Consortium for Networked Biomedical Research) which has established its structure of specialised personnel and commenced support initiatives for the centre´s research along with the collaboration of external centres.

a) el inicio de las acciones de la Unidad Central de Investigación Clínica y Ensayos Clínicos (UCICEC) del hospital, perteneciente al CAIBER (Consorcio de Apoyo a la Investigación Biomédica en Red) que ha sentado su estructura de personal especializado e iniciado labores de apoyo a la investigación del centro junto con colaboraciones con centros externos

b) the subsidy received by the hospital from the Ministry of Science and Innovation (MICINN) to build and start-up a cell therapy room. These complex and costly structures are essential for manufacturing and dispensing in advanced biological treatments in authorised conditions for their administration in selected cases within the context of clinical studies or healthcare interventions. The availability of this room must been considered as an opportunity for our centre to begin translational research lines in areas in which these techniques have already proven to be useful within Regenerative Medicine, which is an area considered to be of preferential interest for healthcare research on a worldwide level. It will also favour the evaluation in controlled conditions of the safety and effectiveness of advanced therapies for pathologies and situations in which current treatments are limited. In summary, it presents an excellent opportunity for combining research of a high technological and scientific level that may be immediately applied to patients and specific problems.

b) la subvención recibida por el hospital por parte del Ministerio de Ciencia e Innovación (MICINN) para la construcción y puesta en marcha de una sala de terapia celular. Estas estructuras, complejas y costosas, son imprescindibles para la fabricación y dispensación en condiciones autorizadas de tratamientos biológicos avanzados para su administración a casos seleccionados en el contexto de ensayos clínicos ó intervenciones asistenciales. La disponibilidad de esta sala debe ser considerada como una oportunidad para que nuestro centro inicie líneas de investigación traslacional en áreas en las que estas técnicas ya han demostrado utilidad, dentro de la llamada Medicina Regenerativa, área considerada de interés preferente en la agenda de investigación sanitaria a nivel mundial. También favorecerá la evaluación en condiciones controladas de la seguridad y eficacia de terapias avanzadas en patologías y situaciones en las que los tratamientos actuales presentan limitaciones. En suma, presenta una excelente oportunidad de combinar investigación de alto nivel tecnológico y científico con aplicación inmediata a pacientes y problemas concretos.

Various circumstances have slowed down the configuration process of the proposal for creating the BioCruces Healthcare Research Institute, but despite this, it continues its path towards the construction of a monographic research building and the preparation of a solid proposal of activities and collaborations.

Diversas circunstancias han llevado a un enlentecimiento del proceso de configuración de la propuesta de creación del Instituto de Investigación Sanitaria BioCruces que, no obstante sigue su camino hacia la construcción de un edificio monográfico de investigación y la elaboración de una propuesta sólida de actividades y cooperaciones.

Some of these circumstances, which are tied to the current economic situation, have also played a role in hindering the preparation of transitory relief measures for the structural limitations of our laboratories and research spaces. These circumstances clearly affect the ability to expand projects and specific groups of basic applied research. Despite this, the hospital´s research, measured in subsidised projects and funds obtained, continues to remain in similar parameters as previous years. This suggests that there is a consolidated foundation for the expected growth when the additional facilities allow it.

Algunas de estas circunstancias, ligadas a la actual situación económica, también han influido en la dificultad de articular medidas transitorias de alivio de las limitaciones estructurales de nuestros laboratorios y espacios de investigación. Estas circunstancias afectan obviamente a la capacidad de crecimiento en proyectos y grupos específicos de investigación básica aplicada. Pese a ello, la investigación del hospital, ��í��ö��Þ��mantiene en parámetros similares a años previos. Ello hace pensar que existe base consolidada para esperar crecimiento en actividad en el momento en que las instalaciones adicionales lo permitan.

The effort towards research is the effort of many professionals on different levels: from the collaboration of patients, who are the origin and purpose of our research, the effort of researchers, including the work of technicians, managers, etc., we must not forget the advisory and support work that the Research Commission and the Clinical Research Ethical Committee continuously provide so that the research that is carried out in our hospital complies with the highest scientific and ethical standards, and that it is applied to resolve relevant healthcare problems.

El esfuerzo en investigación es el esfuerzo de muchos profesionales a diferentes niveles: desde la colaboración de los pacientes, que son el origen y fin de nuestra investigación, al esfuerzo de los investigadores, pasando por el trabajo de técnicos, gestores, etc. no debemos olvidar en esta relación la labor de asesoramiento y apoyo que Comisión de Investigación y el Comité Ético de Investigación Clínica prestan de forma continua para que la investigación que realiza nuestro hospital cumpla los más altos estándares científicos y éticos y se aplique a la resolución de problemas sanitarios relevantes..

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. RESEARCH UNIT

MANAGEMENT AND COORDINATION AREA

CLINICAL EPIDEMIOLOGY UNIT

RESEARCH LABORATORIES

MOLECULAR GENETICS

PULMONARY

PHYSIOPATHOLOGY CELL CULTURE

CLINICAL STUDIES TECHNICAL

SECRETARIAT ANIMAL FACILITY

EXPERIMENTAL

OPERATING ROOM

III- RESEARCH GROUPS (DEFINED IN THE STRATEGIC PLAN AT THE END OF 2009) III- GRUPOS DE INVESTIGACION (DEFINIDOS EN EL PLAN ESTRATEGICO A FINAL DE 2009

GROUP NAME COORDINATOR Anaesthesia and Resuscitation Alberto Martínez Biochemistry-Molecular Genetics Isabel Tejada Stem Cells and Cell Therapy Clara Isabel Rodríguez Dermatology José Luis Díaz Pérez Endocrinology Sonia Gaztambide Paediatric Endocrinology Itxaso Rica Infectious Diseases Miguel Montejo Metabolic, Autoimmune and Rare Diseases Luis Castaño Clinical Epidemiology José I. Pijoán Gastroenterology Javier Bustamante Paediatric Gastroenterology Juan Carlos Vitoria Gynaecology and Human Reproduction Roberto Matorras Immunogenetics Ramón Bilbao Immunology Natalia Maruri Cellular Immunology Susana Larrucea Single-gene diseases of endocrine origin research Guiomar Pérez-Nanclares Internal Medicine Guillermo Ruíz Irastorza

Infant Metabolism Pablo Sanjurjo Nephrology Ildefonso Lampreabe Pulmonology Juan B. Galdiz Neurosurgery Jesús Garibi Clinical Neurology Juan José Zarranz Medical Oncology Guillermo López Vivanco Paediatric Oncology Aurora Navajas Radiotherapeutic Oncology Pedro Bilbao Psychiatry Iñaki Eguíluz Rheumatology Fernando Pérez Transplants Jorge Ortiz de Urbina Paediatric Emergencies Javier Benito

IV- MAIN DISEASES AND HORIZONTAL AREAS PRIORITISED IN THE HOSPITAL (Strategic plan-situation

2009) IV- PRINCIPALES ENFERMEDADES Y ÁREAS HORIZONTALES PRIORIZADAS EN EL HOSPITAL (Plan

estratégico-situación en 2009) DISEASES ENFERMEDADES

Nervous system and sensory organ diseases Enfermedades del Sistema Nervioso y los órganos de los sentidos

Cancer Cáncer Respiratory diseases Enfermedades respiratorias Cardiovascular diseases Enfermedades cardiovasculares Musculoskeletal diseases Enfermedades musculoesqueléticas Endocrine diseases Enfermedades endocrinas Infectious and parasitary diseases Enfermedades infecciosas y parasitarias Mother and child health Salud maternoinfantil HORIZONTAL AREAS ÁREAS HORIZONTALES Biotechnology (Molecular Biology, Genomics, Proteomics, Metabolomics, Nanotechnology)

Biotecnología (Biología Molecular, Genómica, Proteómica, Metabolómica, Nanotecnología)

Pharmaceutical research Investigación farmacéutica Stem cells, regenerative therapy and bioengineering Células madre, terapia regenerativa y Bioingeniería Liver Trasplante Surgery Cirugía Clinical Epidemiology, Public Health and Health Services Epidemiología clínica, Salud Pública y Servicios de Salud Telemedicine Telemedicina Autoimmunity Autoinmunidad

Research Unit Human Resources

recursos humanos de la unidad de investigación

1-UNIT PERSONNEL 1-PERSONAL ADSCRITO A LA UNIDAD

Management and Coordination Area Area de gestión y coordinación 1 Unit Section Chief Doctor 1 médico jefe de sección de la unidad 1 Administrative Assistant 1 auxiliar administrativa 1 Project Manager Technician 1 técnico de gestión de proyectos Clinical Epidemiology Unit Unidad de epidemiología clínica 1 Epidemiologist Doctor 1 médico epidemiólogo1 1 Chemist (Research Fellow) 1 farmacéutica (becaria de investigación) 1 Mathematician (UPV support agreement) 1 1 matemática (apoyo convenio upv) 1 1 Mathematician (contract) 1 matemática (contrato) Clinical research ethics committee Comité ético de investigación clínica 1 Registered Nurse (CEIC Technical Secretariat) 1 due (secretaría técnica ceic) Experimental Area and Laboratories Area experimental y laboratorios A-immunogenetic A-inmunogenetica 1 Research Biologist 1 biólogo investigador 3 Biologists (Research Contracts) 2 3 biólogos (contratos de investigación) 2 3 Biologists (Research Fellows) 3 biólogos (becarios de investigación) B-Stem Cells and Cell Therapy B-celulas madre y terapia celular 1 Research Biologist 1 biólogo investigador 2 Biologists (Research Fellows) 2 biólogos (becarios de investigación)

C-Cellular Immunology C-inmunologia celular 1 Research Biologist 1 biólogo investigador 1 Biochemist (Research Fellow) 1 bioquímico (becario de investigación)

D-Molecular genetics in endocrinology and diabetes D-genetica molecular en endocrinologia y diabetes 1 Research Doctor 1 médico investigador 5 Biologists (Contract) 3 5 biólogos (contrato) 3 1 Biologist (fellow) 1 biólogo (beca) 3 Biochemists (contract) 3 bioquímicos (contrato) 1 Nutritionist degree holder (Contract) 2 1 diplomado en nutrición (contrato) 2 1 manager 1 gestor E-Medical Oncology E-oncología médica 1 Research Biologist 1 biólogo investigador 1 Biologist (Contract) 1 biólogo (contrato) 1 Biologist (Research Fellow) 1 biólogo (becario de investigación) F-Paediatric Oncology F-oncología infantil 1 Biologist (Research Fellow) 1 biólogo (becario de investigación) G-Pulmonary Physiology G-fisiologia pulmonar 1 Research Biologist 1 biólogo investigador

2 Biologists (Contract) 2 2 biólogos (contrato) 2

H-Animal Facility and Experimental Operating Theatre H-estabulario y quirófano experimental 1 Orderly and Animal Facility Carer 1 1 celador y cuidador del estabulario 1 1: part time 1: dedicación parcial 2: 1 Support Technician 2: 1 técnico de apoyo 3: 2 Support Technicians 3: 2 técnicos de apoyo SUPPORT TECHNICIANS LOCATED IN OTHER AREAS TÉCNICOS DE APOYO UBICADOS EN OTRAS ÁREAS 2 Technicians (Infant Metabolism Lab) 2 Técnicos (Laboratorio de Metabolismo Infantil) 1 Technician (Neonatal Epidemiology Unit) 1 Técnico (Unidad de Epidemiología Neonatal) 2-RESEARCH ADVISORY AND REGULATORY BODIES 2-ORGANOS ASESORES Y REGULADORES DE LA

INVESTIGACIÓN

Research Commission Comisión de Investigación Clinical Research Ethical Committee Comité Ético de Investigación Clínica Animal Well-Being Ethical Committee Comité Ético de Bienestar Animal

Activities and Results

actividades y resultados 1. EPIDEMIOLOGY UNIT SCIENTIFIC ADVISORY

1. ASESORÍA CIENTÍFICA DE LA UNIDAD DE EPIDEMIOLOGÍA

Type of Consultation Tipo de Consulta No. of Consultations / Nº Consultas

D.A.I.P. D.A.I.P. 21 D.A.I. D.A.I. 23 A.I.P. A.I.P. 20 A.I. A.I. 34 Mr. D. 17 I.P. I.P. 15 Total Total 130 D: Statistical-epidemiological design TO: Data analysis I: Interpretation of results P: Presentation-publication of results B: Information search (Medline, Internet)

ANIMAL TESTING EXPERIMENTACIÓN ANIMAL

Latxa Sheep Wistar Rat Swiss Rat N.Z. Rabbit Dalland Pig

SERVICE SERVICIO Ovejas Latxa Rata Wistar Ratón Swiss

Conejo N.Z. Cerdo-Dallan

Research Unit Unidad de investigación 14 21Teaching Docencia 28 Urology Urologia 10General Surgery Cirugia general 8Intensive Medicine Medicina intensiva 30 Gynaecology Ginecologia 9Maxillofacial Surgery Cirugia maxilofacial 47 Neonatal Unit Unidad neonatal 23 SUBTOTAL SUBTOTAL 23 119 0 1 48

TOTAL ANIMALS USED 191

Active Research Projects

proyectos de investigación activos

Total no. of projects: 120

Performed in the Research Unit: 56

1st SURNAME 2nd SURNAME NAME SERVICE TITLE FUNDING BODY START

DATE END DATE

ALDAMIZ ECHEVARRIA AZUARA LUIS JOSE PAEDIATRICS -

METABOLISM

POOL OF TRANSPORT AND FUNCTIONAL FATTY ACIDS AS PREDICTORS AND INDICATORS OF GLUCOSE INTOLERANCE IN CYSTIC FIBROSIS

CARLOS III HEALTH INSTITUTE - FIS

23/12/05 30/12/09


METABOLISM

EVALUATION OF ARGININE-GUANIDINOACETATE-CREATINE METABOLISM IN CHRONIC PAEDIATRIC RENAL DISEASE

HEALTH DEPARTMENT

15/12/06 14/12/09


METABOLISM

CENTRALISED CONCEPTUAL KNOWLEDGE MANAGEMENT FOR GUIDE EXECUTION IN CLINICAL PRACTICES WITHIN THE HEALTHCARE ENVIRONMENT

DEPARTMENT OF INDUSTRY

01/01/07 30/06/09


METABOLISM

TRANS-CPG TRANSFER OF CLINICAL PRACTICE GUIDES FOR RARE DISEASES VIA TELEMEDICINE TECHNOLOGIES BY ASSOCIATING INFORMATION AND PROCESSES TO MEDICAL CONCEPTS


01/01/08 31/12/09


METABOLISM

PREVALENCE OF MUCOPOLYSACCHARIDOSIS IN PAEDIATRIC RHEUMATOLOGY CONSULTATIONS IN SPAIN

SPANISH FOUNDATION OF LYSOSOMAL DISEASES (FEEL)

13/02/08 12/02/10

ALVAREZ DIAZ FRANCISCO JOSE RESEARCH

UNIT

DEVELOPMENT OF NEW MEDICAL TECHNOLOGIES FOR THE NEUROPROTECTION OF THE NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY. ENDOCANNABINOID AND THERMAL CONTROL SYSTEMS.


17/10/06 30/12/09

ARICETA IRAOLA Mª GEMA NEPHROLOGY

ENDOTHELIAL DYSFUNCTION AND VASCULAR INFLAMMATION IN CHILDREN AND ADOLESCENTS WITH CHRONIC KIDNEY DISEASE

EITB - TELEMARATOIA

10/12/08 31/12/11

ASTIGARRAGA AGUIRRE MARIA ICIAR PAEDIATRICS -

ONCOLOGY

OBSERVATIONAL STUDY OF THE BEHAVIOUR OF HOSPITALISED MINORS IN LIGHT OF COMPUTER USE AND STIMULUS.

OSAKIDETZA - CRUCES HOSPITAL

25/09/06 23/02/10

ASTIGARRAGA AGUIRRE MARIA ICIAR PAEDIATRICS -

ONCOLOGY

A REFERENCE NETWORK FOR LANGERHANS CELL HISTIOCYTOSIS AND RELATED SYNDROME IN EU

EUROPEAN COMMISSION - DG SANCO

01/09/08 31/08/11

ASTIGARRAGA AGUIRRE MARIA ICIAR

PAEDIATRICS - ONCOLOGY

HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS: DETECTION AND REGISTERING FAMILIAR AND SECONDARY CASES. GENETIC AND IMMUNOLOGICAL CHARACTERISATION OF PATIENTS. PREPARATION AND DISSEMINATION OF RECOMMENDATIONS FOR DIAGNOSIS AND TREATMENT

EITB - TELEMARATOIA

10/12/08 31/12/10

BILBAO CATALA JOSE RAMON RESEARCH

UNIT

STRUCTURAL POLYMORPHISMS AND VARIATIONS IN THE AMOUNT OF GENE COPIES IN THE INNATE IMMUNE RESPONSE TO COELIAC DISEASE.

HEALTH DEPARTMENT

15/12/06 30/04/10


UNIT

KIR RECEPTOR EXPRESSION PROFILE IN COELIAC DISEASE: QUALITATIVE AND QUANTITATIVE STUDIES


12/11/07 30/12/10


UNIT

NFKBCELLI: RESEARCHING NEW THERAPEUTIC TARGETS FOR SELF-IMMUNITY: BLOCKING THE NFKAPPAB ROUTE IN COELIAC DISEASE


01/01/08 31/12/09

BILBAO ZULAICA PEDRO RADIOTHERAP

EUTIC ONCOLOGY

MOLECULAR AND BIOPHYSICS STUDIES OF THE TRANSGLUTAMINASE-2 AS A PROGNOSIS FACTOR IN HEALTHY AND TUMOROUS ORAL CAVITY CELLS. EFFECT OF IONISING RADIATION.

HEALTH DEPARTMENT

15/12/06 14/12/09

BILBAO ZULAICA PEDRO RADIOTHERAP

EUTIC ONCOLOGY

COST-EFFECTIVENESS STUDY IN RADIOTHERAPEUTIC PLANNING WITH PET/CT

HEALTH DEPARTMENT

01/10/08 30/09/09

BUSTAMANTE SCHNEIDER FCO. JAVIER

DIGESTIVE

ASSESSMENT OF PROGNOSIS MARKERS IN RESPONSE TO SORAFENIB IN PATIENTS WITH HAEPATOCELLULAR CARCINOMA AND ITS USE FOR INDIVIDUALISED TREATMENT

HEALTH DEPARTMENT

01/12/08 30/11/11

CABRIADA NUÑO VALENTIN EMERGENCY

ROOM

SITUATION ANALYSIS, SYSTEMATIC REVIEW AND VALIDATION OF A DIAGNOSTIC ALGORITHM FOR PULMONARY EMBOLISM (PE) IN HOSPITAL EMERGENCY ROOM SERVICES WITHIN THE BASQUE HEALTH CARE SERVICE

HEALTH DEPARTMENT

08/08/08 07/08/10

CALVO MARTINEZ MARIA BEGOÑA

ONCOLOGY

ANALYSIS OF THE APOPTOSIS INDEX AS A PREDICTIVE FACTOR OF RESPONSE RATES AND CYTOTOXICITY INDUCED BY RADIO-CHEMOTHERAPY IN THE TREATMENT OF ADVANCED RECTAL CANCER.

HEALTH DEPARTMENT

15/12/06 14/12/09

CARRERA REVILLA SERGIO ONCOLOGY

ANALYSIS OF ESTROGENIC ALPHA AND BETA RECEPTOR EXPRESSION AND AROMATASE ACTIVITY IN RESECTED NON-MICROCYTIC LUNG CANCER AND ITS IMPLICATION AS A PROGNOSIS VARIABLE.

EITB - TELEMARATOIA

12/12/07 30/12/10

CARRERA REVILLA SERGIO

ONCOLOGY

DETERMINATION OF ENDOTHELIAL CIRCULATORY CELLS AND ENDOTHELIAL PROGENITOR CELLS IN PERIPHERAL BLOOD AND OF THE ENDOTHELIAL VASCULAR GROWTH FACTOR IN IMMUNODEPLETED PLASMA, AS PHARMACODYNAMIC MARKERS OF ANTI-ANGIOGENIC ACTIVITY OF BEVACIZUMAB (BV) IN PATIENTS WITH ADVANCED COLORECTAL CANCER.

HEALTH DEPARTMENT

20/10/08 19/10/11

CASTAÑO GONZALEZ LUIS RESEARCH UNIT

PROJECT TO MAKE DNA SAMPLES AVAILABLE OF PATIENTS DIAGNOSED WITH A METABOLIC DISEASE IN THE SPANISH POPULATION. CREATION OF A METABOLISM DNA BANK.

SPAIN GENOME FOUNDATION

01/10/06 30/09/09


NUTRITIONAL PRIMARY PREVENTION OF TYPE 1 DIABETES

NIH (NATIONAL INSTITUTE OF HEALTH) USA

28/03/06 12/02/10

CASTAÑO GONZALEZ LUIS RESEARCH UNIT CIBER RARE DISEASES

INSTITUTO DE SALUD CARLOS III - REDES

02/10/07 01/10/11


CIBER DIABETES AND METABOLIC DISEASES


02/10/07 01/10/11

DE MIGUEL MONIKE PHARMACY

REGULATED INTERVENTION PROGRAMME FOR TREATING CHRONIC HEPATITIS C WITH PEGASYS IN THE HOSPITAL PHARMACY ENVIRONMENT.

LABORATORIOS ROCHE FARMA, SA

30/04/08 30/04/10

EGUILUZ URUCHURTU IÑAKI

PSYCHIATRY

FORMAL EVALUATION OF THE CONSUMPTION OF TOBACCO AND RELATED FACTORS IN EARLY PSYCHOTIC EPISODES


23/12/05 30/06/09

ETXEBARRIA ECENARRO JAIME OPHTHALMOLOGY

DEVELOPMENT OF A DIFFERENTIAL DIAGNOSTIC DEVICE FOR DRY EYE AND BLEPHARITIS


01/01/08 31/12/10

EXPOSITO NAVARRO ANTONIA GYNAECOLOG

Y AND OBSTETRICS

INFLUENCE OF VITAMIN E TREATMENT ON THE ACID-FAT COMPOSITION OF SPERM OF IN-VITRO FERTILISATION PROGRAMME PATIENTS

HEALTH DEPARTMENT

02/10/08 01/10/11

FERNANDEZ MARTINEZ MANUEL NEUROLOGY

ALZHEIMER´S DISEASE: SEARCH FOR PREDICTIVE INDICATORS IN PATIENTS WITH LIGHT COGNITIVE DETERIORATION


23/12/05 30/12/09


ALZHEIMER´S DISEASE: SEARCH FOR PREDICTIVE INDICATORS IN PATIENTS WITH LIGHT COGNITIVE DETERIORATION

HEALTH DEPARTMENT

30/11/07 29/11/10


EARLY DISEASE DETECTION AND STUDY OF PREDICTIVE INDICATORS IN PATIENTS WITH LIGHT COGNITIVE DETERIORATION

LABORATORIOS PFIZER, SA

25/10/05 31/12/09

FORCADAS BERDUSAN MARIA ISABEL NEUROLOGY

EPIDEMIOLOGICAL STUDY OF EPILEPSY IN THE CRUCES HOSPITAL MEDICAL AREA.


23/12/05 15/02/09

FORCADAS BERDUSAN MARIA ISABEL

NEUROLOGY

PROSPECTIVE STUDY OF THE TYPE OF EPILEPTIC CRISES IN A PREVIOUSLY SELECTED POPULATION WITHIN THE AREA OF CRUCES HOSPITAL.

LABORATORIOS EISAI FARMACEUTICA, SA

10/02/09 31/12/09

FORCADAS BERDUSAN MARIA ISABEL NEUROLOGY

EPIDEMIOLOGICAL STUDY OF EPILEPSY IN THE CRUCES HOSPITAL MEDICAL AREA.

HEALTH DEPARTMENT

01/12/08 30/11/11

GALDEANO MIRANDA JOSE MIGUEL

PAEDIATRICS - CARDIOLOGY

EVALUATION OF CONGENITAL HEART DEFECTS IN THE BASQUE AUTONOMOUS COMMUNITY AND NAVARRE

HEALTH DEPARTMENT

17/10/06 30/06/09

GALDIZ ITURRI JUAN BAUTISTA

RESPIRATORY

EUROPEAN NETWORK FOR INVESTIGATING THE GLOBAL MECHANISMS OF MUSCLE ABNORMALITIES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE


28/04/05 31 DEC 09


RESPIRATORY

EVALUATION OF THE USEFULNESS OF MEASURING INSPIRATORY CAPACITY (IC) IN ASSESSING THE BRONCHODILATORY RESPONSE OF COPD PATIENTS

LABORATORIOS BOEHRINGER INGELHEIM ESPAÑA, SA

08/09/08 07/09/09


RESPIRATORY

STUDY TO ASSESS SAFETY AND TOLERANCE DURING NVA 237 TREATMENT IN MODERATE OR SERIOUS COPD PATIENTS.

LABORATORIOS NOVARTIS FARMACEUTICA, SA

04/03/08 03/03/09


RESPIRATORY

MULTICENTRE, DOUBLE-BLINDED, RANDOM AND CONTROLLED STUDY WITH PLACEBO TO DETERMINE THE QVA 149 EFFECT ON THE AVERAGE HEART RATE DURING 24 HOURS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

LABORATORIOS NOVARTIS FARMACEUTICA, SA

04/05/08 03/05/09


RESPIRATORY

RANDOM, MULTICENTRE, DOUBLE-BLINDED, CONTROLLED STUDY WITH PLACEBO ON THE EFFECTIVENESS, SAFETY AND TOLERANCE OF TREATMENT DURING 12 MONTHS WITH 5 MG OF R03300074 ONCE A DAY IN PATIENTS WITH SECONDARY SYMPTOMATIC EMPHYSEMA

LABORATORIOS MEDICAL MARKETING

15/05/06 14/05/09

GARCIA RUIZ JUAN CARLOS

HAEMATOLOGY -

HAEMOTHERAPY

PROSPECTIVE STUDY ON THE USEFULNESS OF COMBINING SEROLOGICAL MARKERS IN DIAGNOSING INVASIVE FUNGAL INFECTIONS.


01/01/08 31/12/10

GARCIA RUIZ JUAN CARLOS

HAEMATOLOGY -

HAEMOTHERAPY

ASSISTANCE TO SUPPORT GROUP RESEARCH ACTIVITIES IN THE BASQUE UNIVERSITY SYSTEM. TYPE A BASQUE GOVERNMENT RESEARCH GROUP.

DEPARTMENT OF EDUCATION

01/01/07 31/12/12

GASTIASORO CUESTA ELENA NEONATOLOGY

EVALUATION OF VARIOUS ADMINISTRATION METHODS OF DIFFERENT SURFACTANTS IN A PREMATURE MODEL OF LAMBS

HEALTH DEPARTMENT

30/11/07 29/11/10

GAZTAMBIDE SAENZ SONIA ENDOCRINOLOGY

STUDY OF COMMON PLYMORPHISMS OF INSULIN SIGNALLING PATHWAY GENES IN PATIENTS WITH EXTREME OBESITY

HEALTH DEPARTMENT

23/02/06 23/02/09

GONZALEZ MIELGO JAVIER PHARMACY

ORGANISATION OF CLINICAL STUDIES IN THE PHARMACY SERVICE. CONTROL AND FOLLOW-UP.


15/11/06 09/10/10

HERNANDEZ ONTORIA ITZIAR HAEMATOLOG

Y - HAEMOTHERA

PY

ANNUAL REGISTRY IN DOMESTIC AND INTERNATIONAL DATABASES OF TRANSPLANT ACTIVITY OF HAEMATOPOIETIC PROGENITORS AT CRUCES HOSPITAL


22/02/07 22/02/09

LABAYEN BERAZA FERMIN INTENSIVE MEDICINE

EARLY INFLAMMATORY FACTORS INVOLVED IN PULMONARY DAMAGE RELATED TO MECHANICAL VENTILATION

HEALTH DEPARTMENT

01/10/08 30/09/11

LARRUCEA BILBAO SUSANA RESEARCH UNIT

STUDY OF MONOCYTE ADHESION, MIGRATION AND ACTIVITY IN PATIENTS WITH TYPE 1 DIABETES MELLITUS AND COELIAC DISEASE


09/01/07 30/12/09


FUNCTIONAL ANALYSIS OF MONOCYTES AND DENDRITIC CELLS IN PATIENTS WITH TYPE 1 DIABETES MELLITUS AND COELIAC DISEASE

HEALTH DEPARTMENT

30/11/07 28/05/11


PODOCALICINA FUNCTION IN THE IMMUNE SYSTEM.


01/01/09 30/12/11

LEZCANO GARCIA ELENA NEUROLOGY

SEARCH FOR GENES INVOLVED IN THE AGE OF APPEARANCE OF HUNTINGTON. GENETIC AND TRANSCRIPTIONAL EXPRESSION ANALYSIS OF GENE CANDIDATES.


01/01/07 30/06/09

LEZCANO GARCIA ELENA NEUROLOGY

GENES THAT MODIFY THE AGE OF APPEARANCE OF HUNTINGTON´S DISEASE. CONFIRMATION OF THE GENETIC ASSOCIATIONS DETECTED.


01/01/08 31/12/09

LOPEZ DE HERRERA

MARIA CRUZ

PAEDIATRICS - NEONATOLOG

Y

SAFETY OF PATIENTS IN NEONATAL INTENSIVE CARE UNITS. WHAT IS THEIR CONDITION IN SPAIN?


12/11/07 30/12/10

LOPEZ VIVANCO GUILLERMO ONCOLOGY

STUDY OF PHARMACOPROTEOMICS IN NON-SMALL CELL LUNG CANCER

HEALTH DEPARTMENT

23/02/06 30/09/09

LOPEZ VIVANCO GUILLERMO

ONCOLOGY SMART INTEGRATED BIODIAGNOSTIC SYSTEM FOR HEALTH CARE

EUROPEAN COMMISSION - DG RESEARCH - VI PM

01/12/05 30/11/09


THEMATIC NETWORK OF COOPERATIVE CANCER RESEARCH


27/10/06 26/10/10


DETERMINATION OF GENETIC STAGE INDICATORS OF COLORECTAL CANCER AND CHEMOTHERAPY RESISTANCE. DEVELOPMENT OF AN IN VITRO MODEL FOR THE STUDY OF EACH STAGE


01/01/07 31/12/09


LABORATORY BAND-AIDS AND SMARTCARDS BASED ON FOILS, COMPATIBLE WITH A SMARTPHONE

EUROPEAN COMMISSION - DG RESEARCH

01/05/08 30/04/12


STUDY OF THE RESPONSE OF A MELANOMA CELL CULTURE TO AN ALIMTA TREATMENT

LABORATORIOS LYLLY, SA

21/02/08 20/02/09

LOPEZ URRUTIA

FERNANDEZ ANTONIO BIOCHEMISTR

Y

DEVELOPMENT OF A CLASSIFICATION SYSTEM OF LABORATORY TESTS THAT PROVIDES CORPORATE MANAGEMENT WITH THE INFORMATION OF THE CLINICAL LABORATORIES

HEALTH DEPARTMENT

09/10/07 08/10/09

LOSADA RODRIGUEZ JOAQUIN GENERAL SURGERY

MODIFICATION OF THE GLUTAMATE RECEPTOR EXPRESSION JOINED TO G PROTEINS WITH A POSSIBLE IMPLICATION IN THE PATHOGEN OF GASTROINTESTINAL TUMOURS AND INFLAMMATORY BOWEL DISEASE

EITB - TELEMARATOIA

12/12/07 30/12/10

LOUREIRO GONZALEZ BEGOÑA NEONATOLOG

Y

DEVELOPMENT OF NEW MEDICAL TECHNOLOGIES FOR THE NEUROPROTECTION OF THE NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY. ENDOCANNABINOID AND THERMAL CONTROL SYSTEMS.

HEALTH DEPARTMENT

15/12/06 14/12/09

MARTINEZ ALDAY NEREA OPHTHALMOLOGY

RETROSPECTIVE STUDY OF THE USE OF ANTI-ANGIOGENICS IN EXUDATIVE ARMD AT CRUCES HOSPITAL.

JESUS DE GANGOITI BARRERA FOUNDATION

01/01/09 30/12/09

MARTINEZ FERNANDEZ RICARDO OPHTHALMOL

OGY

BIOMICS. CUSTOMISED MEDICINE PROJECT. INFLAMMATION IN OCULAR PATHOLOGIES. CHILDREN´S OCULAR ALLERGY


01/01/08 31/12/10

MARTINEZ FERNANDEZ RICARDO OPHTHALMOL

OGY

BIOMICS PROJECT. CUSTOMISED MEDICINE.. PRENATAL DIAGNOSIS OF OCULAR PATHOLOGIES


01/01/08 31/12/10

MARTINEZ RUIZ ALBERTO ANAESTHESIA

AND RESUSCITATI

ON

IMPLEMENTING THE CEREBRAL MICRODIALYSIS TECHNIQUE FOR USE IN HUMANS. APPLICATION OF THE TECHNIQUE IN EPILEPSY SURGERY

HEALTH DEPARTMENT

30/11/07 29/11/10

MATORRAS WEINIG ROBERTO GYNAECOLOG

Y AND OBSTETRICS

ANALYSIS OF FACTORS THAT INFLUENCE NATURAL FERTILITY

LABORATORIO SERONO ESPAÑA, SA

21/11/05 21/11/09

MATORRAS WEINIG ROBERTO GYNAECOLOG

Y AND OBSTETRICS

DEVELOPMENT AND VALIDATION OF A NON-INVASIVE ENDOMETRIOSIS DIAGNOSIS TECHNIQUE PROTEOMIKA, SL

15/06/07 31/12/09

MATORRAS WEINING ROBERTO GYNAECOLOGY AND

OBSTETRICS

FATTY ACID COMPOSITION OF HUMAN SPERM AND SEMINAL PLASMA: RELATION TO SPERM MOTILITY.


01/01/09 30/12/09

MENDIBE BILBAO MAR NEUROLOGY

STUDIES ON MULTIPLE SCLEROSIS (MS) AND PREGNANCY. INFLUENCE OF MATERNITY ON MS AND INFLUENCE OF MS ON PREGNANCY.

LABORATORIOS SERONO ESPAÑA, SA

01/02/06 31/12/09

MONTEJO BARANDA MIGUEL INFECTIOUS DISEASES

SPANISH RESEARCH NETWORK OF INFECTIOUS PATHOLOGY (REIPI)


27/10/06 26/10/10

MUHIAL DIN JANGI SH.

ONCOLOGY

ANALYSIS OF THE APOPTOSIS INDEX AS A PREDICTIVE FACTOR OF RESPONSE RATES AND TOXICITY INDUCED BY CHEMOTHERAPY AND/OR RADIOTHERAPY IN THE TREATMENT OF ADVANCED NON-MICROCYTIC LUNG CANCER.


12/11/07 30/12/10

MUÑOZ LLARENA ALBERTO

ONCOLOGY

PROSPECTIVE EVALUATION OF THE PROTECTIVE ROLE OF ERITROPOYETINE IN NEUROTOXICITY INDUCED BY OXALIPLATINE AND ITS RELATION TO THE I105V POLYMORPHISM IN GLUTATHIONE S-TRANSFERASE P1 IN PATIENTS WITH COLORECTAL CANCER AND ANEMIA

HEALTH DEPARTMENT

23/02/06 23/02/09

MUÑOZ LLARENA ALBERTO

ONCOLOGY

DETERMINATION OF ENDOTHELIAL CIRCULATORY CELLS AND ENDOTHELIAL PROGENITOR CELLS IN PERIPHERAL BLOOD AND OF THE ENDOTHELIAL VASCULAR GROWTH FACTOR IN IMMUNODEPLETED PLASMA, AS PHARMACODYNAMIC MARKERS OF ANTI-ANGIOGENIC ACTIVITY OF BEVACIZUMAB

MUTUA MADRILEÑA FOUNDATION

02/10/08 01/10/11

(BV) IN PATIENTS WITH ADVANCED COLORECTAL CANCER.

NAVAJAS GUTIERREZ AURORA


MOLECULAR AND IMMUNOHISTOCHEMICAL STUDIES OF VARIOUS TUMOROUS INDICATORS IN THE MOST FREQUENT FORMS OF PAEDIATRIC BRAIN CANCER; GLIOMAS AND MEDULOBLASTOMAS. ANALYSIS OF THE VALUE OF GENETIC ALTERATIONS FOR PREDICTING THE TREATMENT RESPONSE.

HEALTH DEPARTMENT

30/11/07 29/11/10

NAVAJAS GUTIERREZ AURORA PAEDIATRICS - ONCOLOGY

EXPANSION AND STRUCTURING OF THE LIBRARY AND BANK OF TUMOURS OF CHILDREN WITH CANCER IN THE CRUCES PAEDIATRIC ONCOLOGY UNIT

EITB - TELEMARATOIA

12/12/07 30/12/10

ORTIZ DE URBINA LOPEZ JORGE SURGERIES

AND TRANSPLANTS

OBTAINING BIOLOGICAL SAMPLES FOR THE "DEVELOPMENT OF A BIOCHIP FOR DIAGNOSIS-PROGNOSIS OF COLORECTAL CARCINOMA" PROJECT


23/12/08 22/12/09

ORTIZ DE URBINA LOPEZ JORGE SURGERIES

AND TRANSPLANTS COORDINATOR OF CLINICAL STUDIES


15/09/08 14/09/09

PEREZ DE NANCLARES LEAL GUIOMAR RESEARCH

UNIT SEARCH FOR NEW GENES RESPONSIBLE FOR SINGLE-GENE DIABETES


17/10/06 30/12/09


UNIT SEARCH FOR NEW GENES RESPONSIBLE FOR SINGLE-GENE DIABETES.


01/01/09 30/12/09

PEREZ DE NANCLARES LEAL GUIOMAR

RESEARCH UNIT

MOLECULAR GENETICS OF ENDOCRINE-RELATED RARE DISEASES

SEEP-FUNDA. SOC. ESPAÑOLA DE ENDOCRINOLOGIA PEDIATRICA

20/10/08 19/10/09


UNIT

GENETIC AND ENVIRONMENTAL CAUSES OF CONGENITAL MALFORMATION SYNDROMES.


01/01/09 01/01/10


UNIT

GENETIC CLINICAL CHARACTERISATION OF PATIENTS WITH TYPE I PSEUDOHYPOPARATHYROIDISM AND PSEUDOPSEUDOHYPOPARATHYROIDISM

HEALTH DEPARTMENT

08/10/08 07/10/11


UNIT

PSEUDOHYPOPARATHYROIDISM AND PSEUDOPSEUDOHYPOPARATHYROIDISM: CLASSIFICATION AND CLINICAL-GENETIC CHARACTERISATION

EITB - TELEMARATOIA

10/12/08 31/12/11

PERTUSA PEÑA CARLOS UROLOGY

IDENTIFICATION AND CLINICAL VALIDATION OF NEW MOLECULAR MARKERS FOR SUPERFICIAL AND INVASIVE BLADDER CANCER.


19/05/08 18/05/10

PERTUSA PEÑA CARLOS UROLOGY

IDENTIFICATION AND CLINICAL VALIDATION OF NEW MOLECULAR MARKERS FOR SUPERFICIAL AND INVASIVE BLADDER CANCER.


23/12/08 22/12/09

PIJOAN ZUBIZARRETA

JOSE IGNACIO RESEARCH

UNIT

EFFECTIVENESS OF THE ECOENDOSCOPY IN THE DIAGNOSIS OF THE ONCOLOGIC DIGESTIVE PATHOLOGY. REVIEW AND COMPARISON WITH OTHER TECHNIQUES


21/12/06 30/09/09

PIJOAN ZUBIZARRETA

JOSE IGNACIO RESEARCH

UNIT CAIBER CRUCES HOSPITAL


01/01/09 30/12/12

QUESADA RAMOS CRISTINA PAEDIATRIC ICU

TRANSLATION AND VALIDATION OF THE SPANISH VERSION OF THE BRADEN Q SCALE IN A PAEDIATRIC POPULATION

HEALTH DEPARTMENT

26/10/07 01/05/09

RODRIGUEZ LOPEZ CLARA ISABEL RESEARCH

UNIT

GENERATION OF DIABETES MODELS BY HOMOLOGOUS RECOMBINATION IN HUMAN EMBRYONIC STEM CELLS.


16/01/06 16/01/09

RODRIGUEZ LOPEZ CLARA ISABEL RESEARCH

UNIT

GENERATION OF HUMAN DISEASE MODELS BY HOMOLOGOUS RECOMBINATION IN HUMAN EMBRYONIC STEM CELLS.


17/10/06 30/12/10

RODRIGUEZ LOPEZ CLARA ISABEL

RESEARCH UNIT

INMEPER: IT AND ENGINEERING APPLIED TO PREVENTIVE AND REGENERATIVE MEDICINE


01/01/08 30/12/09

RUIZ IRASTORZA GUILLERMO INTERNAL MEDICINE

SINANGEN: IDENTIFICATION OF GENES SUSCEPTIBLE TO THE ANTIPHOSPHOLIPID SYNDROME THROUGH THE ANALYSIS OF SNP POLYMORPHISMS


01/01/08 31/12/09

RUIZ DE LOBERA MARTINEZ ABIGAIL

ONCOLOGY

CEA MRNA EXPRESSION IN PERIPHERAL BLOOD THROUGH RQ-PCR AS A PREDICTIVE FACTOR OF RELAPSES IN TRACKING PATIENTS WITH STAGE III COLORECTAL CANCER

HEALTH DEPARTMENT

30/11/07 29/11/10

RUIZ DE LOBERA MARTINEZ ABIGAIL

ONCOLOGY

POLYMORPHISM GENOTYPING AND GENE EXPRESSION AS A PREDICTIVE RESPONSE FACTOR TO CHEMOTHERAPY AND ITS PROGNOSTIC INVOLVEMENT IN PATIENTS WITH BREAST CARCINOMA SUBJECT TO NEOADJUVANT CHEMOTHERAPY

MUTUA MADRILEÑA FOUNDATION

02/10/08 01/10/11

SANJURJO CRESPO PABLO PAEDIATRICS - METABOLISM

POOL OF TRANSPORT AND FUNCTIONAL FATTY ACIDS AS PREDICTORS AND INDICATORS OF GLUCOSE INTOLERANCE IN CYSTIC FIBROSIS

HEALTH DEPARTMENT

23/02/06 23/02/09


EVALUATION OF THE COMPOSITION OF FATTY ACIDS IN PATIENTS WITH BETA-OXIDATION DEFECTS TREATED WITH TRIHEPTANOINE


26/11/07 30/12/10


RELEVANCE BETWEEN LYPOTOXICITY AND CARDIOVASCULAR RISK WITH THE EVOLUTION OF THE DISEASE IN PATIENTS WITH PROTEINURIA


12/11/07 30/12/10


EVALUATION OF THE COMPOSITION OF FATTY ACIDS IN PATIENTS WITH BETA-OXIDATION DEFECTS TREATED WITH TRIHEPTANOINE

EITB - TELEMARATOIA

10/12/08 31/12/10


STUDY OF GUANIDINOACETATE-CREATINE-CREATINE METABOLISM IN NEWBORNS, RELATED CLINICAL FACTORS AND EVOLUTION.

HEALTH DEPARTMENT

07/10/08 06/10/11


MOTHER-CHILD HEALTH AND DEVELOPMENT NETWORK


01/01/09 31/12/12

SANTAMARIA ZUAZUA JOSEBA ANDONI

MAXILLOFACIAL SURGERY

CLINICAL TRIAL FOR THE EFFECTIVENESS OF A GUIDELINE WITH AMOXICILLIN/CLAVULANIC 2000/125 MG (GE) EVERY TWELVE HOURS, COMPARED TO PLACEBO (GC) IN PREVENTING POST-OPERATION INFECTION AFTER THE EXTRACTION OF THIRD MOLARS COMPLETELY ENCASED IN THE JAWBONE (BONY IMPACTION).


01/01/09 30/12/11

TEJADA MINGUEZ MARIA ISABEL

GENETICS

FRAGILE X SYNDROME: EVALUATION OF THE EFFICACY, EFFECTIVENESS, SAFETY OF DIAGNOSIS AND TREATMENT, AND ANALYSIS OF FAIRNESS IN ACCESS TO SERVICES IN SPAIN


17/12/07 30/06/09


GENETICS

STUDY OF THE POSSIBLE PATHOGENIC EFFECT (OR NOT) OF THE MISSENSE AND NONSENSE VARIATIONS IN THE GENES WITH A PREDISPOSAL TO NON-POLYPOSIC COLON CANCER AND HEREDITARY BREAST/OVARIAN CANCER, BOTH THE CLASSIC AS WELL AS OTHERS TO BE VERIFIED

EITB - TELEMARATOIA

12/12/07 30/12/10

TEJADA MINGUEZ MARIA ISABEL GENETICS

CLINICAL ANALYSIS RELATED TO THE MECP2, CDKL5 AND NETRIN G1 GENE MUTATIONS AND THEIR RELATIONSHIP WITH THE RETT SYNDROME

HEALTH DEPARTMENT

01/01/08 31/12/11


GENETICS

PATHOLOGICAL MUTATIONS OF CERTAIN GENES IN WOMEN WITH BREAST/OVARIAN CANCER.

GIPUZKOA WOMEN´S GYNAECOLOGICAL AND BREAST CANCER ASSOC.

12/06/08 11/06/09


RESEARCH OF THE GENETIC ORIGIN OF MENTAL RETARDATION (CRUCES HOSPITAL GIRMOGEN)

EITB - TELEMARATOIA

10/12/08 30/12/10


ARTICLE AWARD - GENE MUTATION CHECK

LABORATORIOS SCHERING-PLOUGH, SA

09/05/08 08/05/09

VALLS I SOLER ADOLFO PAEDIATRICS - NEONATOLOG

Y

EUROPEAN INFORMATION SYSTEM TO MONITOR SHORT AND LONG-TERM MORBIDITY TO IMPROVE QUALITY OF CARE AND PATIENT-SAFETY FOR VERY-LOW-BIRTH-WEIGHT INFANTS


01/01/06 31/12/09


Y

EXPANDED EUROPEAN SYSTEM TO MONITOR SHORT AND LONG TERM OUTCOMES AND IMPROVE QUALITY OF CARE AND SAFETY FOR VERY-LOW-B.


01/11/09 31/10/12


Y

EVALUATION OF VARIOUS ADMINISTRATION METHODS OF DIFFERENT SURFACTANTS IN A PREMATURE MODEL OF LAMBS


12/11/07 30/03/11


Y

COLLABORATION OF THE PULMONARY PHYSIOLOGY LABORATORY OF CRUCES HOSPITAL´S RESEARCH UNIT

PRIVATE PHYSICIANS ASSOCIATION: NEONATAL STUDIES

07/11/08 06/11/09


Y

"IN VITRO" AND "IN VIVO" IMPLEMENTATION AND ASSESSMENT OF A NEBULISER PROTOTYPE. ADMINISTRATION OF NEBULISED SURFACTANTS AND PERFLUOROCARBONS


01/01/08 31/12/09


Y

RESULTS OF PERINATAL CARE FOR PREMATURE PREGNANCIES IN THE BASQUE COUNTRY´S HEALTHCARE NETWORK

HEALTH DEPARTMENT

01/10/08 30/09/10


Y EURONEOSTAT SUPPORT PROGRAMME - SAMID NETWORK

LABORATORIOS PFIZER, SA

15/02/08 14/02/09


Y MOTHER-CHILD HEALTH AND DEVELOPMENT NETWORK


01/01/09 31/12/12

VELA DESOJO AMAIA PAEDIATRICS - ENDOCRINOL

OGY

EVALUATION OF THE METABOLIC SYNDROME IN OBESE CHILDREN, GENETIC STUDY AND RELATION WITH THE EVOLUTION OF THE DISEASE

HEALTH DEPARTMENT

23/02/06 23/02/09

VELA DESOJO AMAIA PAEDIATRICS - ENDOCRINOL

OGY

RETROSPECTIVE STUDY OF THE EFFECTIVENESS AND POSSIBLE SIDE EFFECTS IN PATIENTS WITH GROWTH HORMONE (GH) TREATMENT AND THAT OF RELATED SUBSTANCES WITHIN THE AUTONOMOUS BASQUE COMMUNITY

HEALTH DEPARTMENT

01/10/08 30/09/10

VITORIA CORMENZANA

JUAN CARLOS PAEDIATRICS -

DIGESTIVE

VALIDATION OF THE NUTRITIONAL CONDITION OF OUTPATIENT AND HOSPITALISED PAEDIATRIC PATIENTS AT CRUCES HOSPITAL´S PAEDIATRIC SERVICE

LABORATORIO NOVARTIS CONSUMER HEALTH, SA

12/02/08 11/02/09

VITORIA CORMENZANA

JUAN CARLOS PAEDIATRICS -

DIGESTIVE

PROSPECTIVE STUDY ON THE OVERALL HEALTH AND GLUTEN FREE DIET OF PEOPLE DIAGNOSED WITH COELIAC DISEASE MORE THAN 20 YEARS AGO

HEALTH DEPARTMENT

01/12/08 30/11/11

Thematic Networks

redes temáticas CIBERS AND THEMATIC NETWORKS OF COOPERATIVE RESEARCH (RETICS) IN WHICH THE HOSPITAL PARTICIPATES. CIBERS Y REDES TEMÁTICAS DE INVESTIGACIÓN COOPERATIVAS (RETICS) EN LAS QUE PARTICIPA EL HOSPITAL.

Service Researcher Ciber / retic Agency Servicio Investigador Agencia

Research Unit Luis Castaño Diabetes and related metabolic diseases (ciber) ISCIII Research Unit Luis Castaño Rare Diseases (ciber) ISCIII Research Unit Jose I Pijoán Epidemiology and Public Health (ciber) ISCIII

Infectious Diseases Unit Miguel Montejo Spanish Research Network of Infectious Pathology-Reipi (retic)

ISCIII

Medical Oncology Guillermo López Vivanco

Thematic Network of Cooperative Cancer Research (retic)

ISCIII

Neonatal Unit Adolf Valls Thematic Network of Mother-Child Health (retic) ISCIII Infant Metabolism Pablo Sanjurjo Thematic Network of Mother-Child Health and

Development (retic) ISCIII

Research Unit Jose I Pijoán Caiber ISCIII

The hospital maintains its participation in research Networks and Cibers. The Diabetes Thematic Network has disappeared, but the CAIBER node and the Mother-Child Health Thematic Network have been added, coordinated from the Neonatal Unit.

TOTAL RESEARCH PROJECTS ACTIVE DURING THE 2000 TO 2009 PERIOD TOTAL PROYECTOS DE INVESTIGACIÓN ACTIVOS PERIODO 2000 A 2009

FINANCIAL RESOURCES RECURSOS ECONOMICOS

FINANCING OBTAINED FINANCIACIÓN OBTENIDA Research projects Proyectos de investigación 1.857.290,67Scientific infrastructure: Infraestructura científica: 650.020,42FIS Research Personnel Personal Investigador FIS 486.389,78Clinical Studies (evaluation costs+ indirect costs) Ensayos Clínicos (Costes evaluación

+ costes indirectos) 317.429,14

TOTAL TOTAL 3.311.130,01

1: Includes resources for training research personnel.

Annual project funding

financiación anual de proyectos RESEARCH PROJECTS FROM 1990 TO 2009

PROJECTS REQUESTED

FINANCED % FINANCED

YEAR PROYECTOS SOLICITADOS

FINANCIADOS % FINANCIADOS

1990 22 9 41% 1991 17 8 47% 1992 18 15 83% 1993 12 8 67% 1994 17 10 59% 1995 35 20 57% 1996 18 10 56% 1997 17 8 47% 1998* 27 19 70% 1999* 17 9 53% 2000 12 6 50% 2001 Non-convocation / No

convocatoria - -

2002 20 13 65% 2003 36 14 39% 2004 26 14 54% 2005 33 15 45% 2006 39 17 44% 2007 65 31 48% 2008 59 48 81% 2009 102 45 44% Total 592 319 54%

* Includes: Projects requested to FIS, Department of Health Care, Department of Education, University of the Basque Country, BIOEF Basque Foundation, and private entities (BBK, pharmaceutical industry or scientific societies, except clinical studies).

* Se incluyen: Proyectos solicitados a FIS, Dpto. Sanidad, Dpto. Educación, Universidad del Pais Vasco, Fundación Vasca BIOEF y entidades privadas (BBK, industria farmaceútica o Sociedades Científicas, excepto ensayos clínicos).

IX-RESEARCH PROJECTS FINANCED IX-PROYECTOS DE INVESTIGACIÓN FINANCIADOS

44 projects financed in 2009 in public and private convocations - 11 to be completed in the Research Unit

NAME SERVICE TITLE FUNDING BODY

CIRIACO AGUIRRE ERRASTI

INTERNAL MEDICINE

CLINICAL TRIAL OF IRON DEFICIENCY ANAEMIA OF UNKNOWN AETIOLOGY AND/OR REFRACTORY. JESÚS DE GANGOITI FOUNDATION

LUIS JOSÉ ALDAMIZ-ECHEVARRIA AZUARA

PAEDIATRICS - METABOLISM

VERIFICATION, EXECUTION AND APPLICATION OF PROCEDURAL KNOWLEDGE OF CLINICAL PRACTICE GUIDES REPRESENTED WITH ARCHETYPES INCLUDING INTERACTION WITH EHRS.

DEPARTMENT OF INDUSTRY - BASQUE GOVERNMENT

FRANCISCO JOSÉ ALVAREZ DIAZ

RESEARCH UNIT

STUDY ON THE SAFETY OF USING CANNABINOIDS IN AN EXPERIMENTAL NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY MODEL.


FRANCISCO JOSÉ ALVAREZ DIAZ

PAEDIATRICS - NEONATOLOGY - RESEARCH UNIT

DEVELOPMENT OF PRE-CLINICAL STUDIES IN THE PAEDIATRIC AREA. SUCLISA, SL

MARÍA GEMA ARICETA IRAOLA

PAEDIATRIC NEPHROLOGY

DEVELOPMENT OF A MOLECULAR CLINICAL STUDY SYSTEM FOR PRIMARY TUBULOPATHIES THAT MAXIMISES THE SCIENTIFIC OUTPUT OF INFORMATION AND OF THE DIAGNOSTIC PROCEDURES.


MARIA ICIAR ASTIGARRAGA AGUIRRE


PREPARATION OF THE CENSUS OF CHILDREN AFFECTED BY HISTIOCYTOSIS IN SPAIN.

SPANISH SOCIETY AGAINST HISTIOCYTOSIS

JOSÉ RAMÓN BILBAO CATALA RESEARCH UNIT

STUDY OF TH17 CELLS IN COELIAC DISEASE MUTUA MADRILEÑA FOUNDATION

JOSÉ RAMÓN BILBAO CATALA

RESEARCH UNIT

STRATEGIC RESEARCH AND TECHNOLOGICAL DEVELOPMENT IN SIGNALLING AND CANCER, PROTEOMIC AND GENOMIC


JORGE BURGOS SAN CRISTOBAL

OBSTETRICS

ANALYSIS OF THE DIFFERENT COMPONENTS OF THE BISHOP TEST AS SUCCESS PREDICTORS FOR INDUCING LABOUR. JESÚS DE GANGOITI FOUNDATION

JORGE BURGOS SAN CRISTOBAL

OBSTETRICS

COMPARATIVE STUDY OF TWO TOCOLYTICS (ATOSIBAN VS RITODRINE) FOR FULL TERM EXTERNAL CEPHALIC VERSION IN BREECH BIRTHS. JESÚS DE GANGOITI FOUNDATION

LUIS CASTAÑO GONZALEZ

RESEARCH UNIT

NEONATAL DIABETES AND OF EARLY APPEARANCE: MOLECULAR CHARACTERISATION AND PHENOTYPE.



RESEARCH UNIT

DIABETES EPIDEMIOLOGY IN THE BASQUE COUNTRY (EARLY DETECTION AND POPULATION SCREENING OF DIABETES IN THE BASQUE COUNTRY - PREVALENCE OF DIABETES IN THE BASQUE COUNTRY).

DEPARTMENT OF HEALTHCARE AND CONSUMPTION - BASQUE GOVERNMENT


RESEARCH UNIT

ENCAPSULATION OF MOUSE PANCREATIC ISLETS: ANALYSIS OF IN VITRO AND IN VIVO FUNCTIONALITY AND RE-VASCULARISATION.



RESEARCH UNIT

TRIGGER STUDY: NUTRITIONAL PREVENTION OF IDDM IN GENETICALLY AT-RISK CHILDREN.

NIH (NATIONAL INSTITUTE OF HEALTH) USA

SANDRA DE FERNANDO AISA OPHTHALMOLOGY

TOPICAL ANAESTHETIC IN STRABISMUS. JESÚS DE GANGOITI FOUNDATION

MANUEL FERNANDEZ MARTINEZ

NEUROLOGY

EARLY DISEASE DETECTION AND STUDY OF PREDICTIVE INDICATORS IN PATIENTS WITH LIGHT COGNITIVE DETERIORATION

LABORATORIOS EISAI FARMACÉUTICA, SA

FRANCISCO JAVIER GAINZA DE LOS RIOS NEPHROLOGY

COLLABORATION IN RESEARCH PROJECT FOR THE NEPHROLOGY AREA.

LABORATORIOS ASTELLAS PHARMA, SA

JUAN BAUTISTA GALDIZ ITURRI

PULMONOLOGY

ASSESSING THE EFFECTIVENESS OF REPETITIVE MAGNETIC STIMULATION OF QUADRICEPS IN COPD PATIENTS AFTER HOSPITALISATION FOR EXACERBATION.


JUAN CARLOS GARCIA RUIZ

HAEMATOLOGY

ANNUAL REGISTRY IN DOMESTIC AND INTERNATIONAL DATABASES OF TRANSPLANT ACTIVITY OF HAEMATOPOIETIC PROGENITORS AT CRUCES HOSPITAL OSAKIDETZA - CRUCES HOSPITAL

JUAN CARLOS GARCIA RUIZ

HAEMATOLOGY

PROSPECTIVE STUDY ON THE USEFULNESS OF COMBINING SEROLOGICAL MARKERS IN DIAGNOSING INVASIVE FUNGAL INFECTIONS.

LABORATORIOS GILEAD SCIENCES, SL

JUAN CARLOS GOMEZ ESTEBAN

NEUROLOGY

STUDY OF THE VEGETATIVE NERVOUS SYSTEM IN PATIENTS WITH PARKINSON´S DISEASE WHO ARE CARRIERS OF THE E46K MUTATION OF THE SCNA GENE AND OF THE R1441G OF THE LRRK2 GENE.


EDUARDO IBAÑEZ FEIJOO ONCOLOGIC

GYNAECOLOGY

GENETIC AETIOLOGY OF ENDOMETRIAL CANCER AND ITS RELATION WITH THE DNA REPAIR GENES (MMR) (MLH1, MSH2 AND MSH6).


ILDEFONSO LAMPREABE GAZTELU

NEPHROLOGY

BIOTECHNOLOGY APPLIED TO THE DEVELOPMENT OF NEW DIAGNOSIS AND PROGNOSIS TOOLS FOR COMPLEX DISEASES.

PRIVATE PHYSICIANS ASSOCIATION: CRUCES HOSPITAL NEPHROLOGISTS

PLÁCIDO LOPEZ ALVAREZ-BUHILLA

CHILD SURGERY

MOLECULAR CHARACTERISATION IN CHILDREN WITH HIRSCHSPRUNG'S DISEASE.


GUILLERMO LOPEZ VIVANCO

MEDICAL ONCOLOGY

IDENTIFICATION OF BIOMARKERS FOR THE RECURRENCE OF LUNG CANCER USING GENOMIC TOOLS.


ANTONIO LOPEZ URRUTIA FERNANDEZ BIOCHEMISTRY

ROCHE INVOICING: EVALUATION OF ANALYTICAL SYSTEMS.

LABORATORIOS ROCHE DIAGNOSTICS, SL

MIGUEL MONTEJO BARANDA

INFECTIOUS DISEASES

FIPSE STUDY ABOUT LIVER TRANSPLANTS IN PATIENTS INFECTED WITH HIV IN SPAIN (2005-2008). GESIDA 45-05 STUDY.

FOUNDATION FOR RESEARCH AND PREVENTION OF AIDS IN SPAIN (FIPSE) GESIDA STUDY 45-05

(2ND PHASE: 2009-2011)

MIGUEL MONTEJO BARANDA INFECTIOUS DISEASES

COLLABORATION IN LIVER TRANSPLANT PROJECT FOR PATIENTS INFECTED WITH HIV.

LABORATORIOS NOVARTIS FARMACÉUTICA, SA



LABORATORIOS ROCHE FARMA, SA



LABORATORIOS GILEAD SCIENCES, SL

CLARA ISABEL RODRIGUEZ LOPEZ RESEARCH UNIT

INMEPER: IT AND ENGINEERING APPLIED TO PREVENTIVE AND REGENERATIVE MEDICINE II.


CLARA ISABEL RODRIGUEZ LOPEZ

RESEARCH UNIT

INMEPER: IT AND ENGINEERING APPLIED TO PREVENTIVE AND REGENERATIVE MEDICINE.

MONDRAGON GOI ESKOLA POLITEKNIKOA JOSE MARIA ARIZMENDIARRETA, S.COOP.

GUILLERMO RUIZ IRASTORZA

INTERNAL MEDICINE

CLINICAL TRIAL ON THE EFFECT OF CORTICOSTEROIDS FOR THE CHRONIC DAMAGE OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS. JESÚS DE GANGOITI FOUNDATION


INTERNAL MEDICINE

STUDY ON THE INFLUENCE OF MICRO-RNAS IN SUSCEPTIBILITY TO ANTIPHOSPHOLIPID SYNDROME.



INTERNAL MEDICINE

COLLABORATION IN THE PROJECT FOR THE IDENTIFICATION OF GENES SUSCEPTIBLE TO THE ANTIPHOSPHOLIPID SYNDROME THROUGH THE ANALYSIS OF SNP POLYMORPHISMS.

PRIVATE PHYSICIANS ASSOCIATION: GENERAL PRACTITIONERS AT CRUCES HOSPITAL

PABLO SANJURJO CRESPO PAEDIATRICS -

METABOLISM

RELEVANCE OF OMEGA-3 FATTY ACIDS IN THE OSTEOPENIA OF CHILDREN AFFECTED BY PHENYLKETONURIA. MUTUA MADRILEÑA FOUNDATION

JOSEBA SANTAMARIA ZUAZUA

MAXILLOFACIAL SURGERY

FOSTERING THE CLINICAL TRIAL ON THE EFFECTIVENESS OF A GUIDELINE WITH AMOXICILLIN/CLAVULANIC 2000/125 MG (GE) EVERY TWELVE HOURS, COMPARED TO PLACEBO (GC) IN PREVENTING POST-OPERATION INFECTION AFTER THE EXTRACTION. LABORATORIOS ZAMBON, SA

Mª ISABEL TEJADA MINGUEZ MOLECULAR GENETICS

LABORATORY

THE SEARCH FOR GENETIC AETIOLOGY IN HEREDITARY CANCER. JESÚS DE GANGOITI FOUNDATION

ADOLFO VALLS SOLER PAEDIATRICS - NEONATOLOGY

PERFORMING A STUDY ON CENTRAL NEONATAL CARE IN DEVELOPMENT. SITUATION IN SPAIN.

MINISTRY OF HEALTHCARE AND SOCIAL POLICIES

ADOLFO VALLS SOLER

PAEDIATRICS - NEONATOLOGY

CHARACTERISATION OF HOSPITAL INFECTIONS IN PREMATURE BABIES WITH A VERY LOW WEIGHT: PREVENTION AND RISK FACTORS. JESÚS DE GANGOITI FOUNDATION

ADOLFO VALLS SOLER PAEDIATRICS - NEONATOLOGY

EXPANDED EUROPEAN SYSTEM TO MONITOR SHORT AND LONG TERM OUTCOMES AND IMPROVE QUALITY OF CARE AND SAFETY FOR VERY-LOW-B.


JUAN CARLOS VITORIA CORMENZANA

PAEDIATRICS - DIGESTIVE

VALIDATION OF THE NUTRITIONAL CONDITION OF OUTPATIENT AND HOSPITALISED PAEDIATRIC PATIENTS AT CRUCES HOSPITAL´S PAEDIATRIC SERVICE

NESTLÉ HEALTHCARE NUTRITION, SA

JUAN JOSÉ ZARRANZ IMIRRALDU

NEUROLOGY

STUDY OF THE VEGETATIVE NERVOUS SYSTEM IN PATIENTS WITH FAMILIAL PARKINSON´S DISEASE WHO ARE CARRIERS OF E46K IN ALPHA-SYNUCLEIN OR R1441G IN DARDARIN/LRRK2.


JUAN JOSÉ ZARRANZ IMIRRALDU

NEUROLOGY

STUDY OF THE VEGETATIVE NERVOUS SYSTEM IN PATIENTS WITH PARKINSON´S DISEASE WHO ARE CARRIERS OF E46K IN ALPHA-SYNUCLEIN OR R1441G IN DARDARIN/LRRK2.


ACTIVE CLINICAL STUDIES

ENSAYOS CLÍNICOS ACTIVOS CLINICAL STUDIES APPROVED DURING THE PERIOD 2000-2009, CLASSIFIED ACCORDING TO THE PROMOTER ENSAYOS CLINICOS APROBADOS EN EL PERIODO 2000-2009 CLASIFICADOS SEGÚN EL PROMOTOR In 2009, the CEIC has approved 39 new clinical studies to be carried out. 47 were submitted for evaluation.

C.E.I.C Approved Clinical Studies

2000/2009

SERVICE/CENTRE 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 TOTAL ANAESTHESIA 0 0 1 1 3 1 2 0 2 0 10HEART SURGERY 3 0 0 0 0 0 1 0 0 0 4

ALGORTA HEALTH CENTRE 1 0 0 0 0 0 0 2 0 0 3

ARANA HEALTH CENTRE 1 0 0 0 0 0 0 0 0 0 1

KUETO HEALTH CENTRE 0 1 0 0 1 0 1 0 0 0 3

GALLARTA HEALTH CENTRE 0 1 0 0 0 0 0 0 0 0 1

LA PAZ HEALTH CENTRE 0 0 1 0 0 0 0 0 0 0 1

PORTUGALETE HEALTH CENTRE 1 0 1 0 0 1 0 0 0 0 3

S. VICENTE HEALTH CENTRE 1 0 0 0 1 0 0 0 0 0 2

MENTAL HEALTH CENTRE 0 0 0 1 1 0 0 0 1 0 3CARDIOLOGY 0 0 1 0 3 0 0 1 1 2 5GENERAL SURGERY 2 1 3 2 2 2* 0 1 1 1 13

MAXILLOFACIAL SURGERY 0 0 0 0 0 0 0 0 1 0 1VASCULAR SURGERY 0 0 0 1 0 0 0 0 0 0 1DERMATOLOGY 1 1 3 3 2 3 1 1 0 0 15DIGESTIVE 3 3 3 1 1 4 3 1 3 1 22

CHILD ENDOCRINOLOGY 1 1 0 1 0 0 0 0 1 0 4ENDOCRINOLOGY 1 6 3 3 4 2 5 0 3 2 27GYNAECOLOGY 1 1 0 2 1 1* 0 1 0 2 7HAEMATOLOGY 1 1 0 0 0 5 3 1 0 2 11SAN ELOY HOSPITAL 0 2 4 0 5 1 0 1* 0 0 13

PAEDIATRIC INFECTIONS 0 0 0 0 0 0 0 0 0 0 0INTENSIVE MEDICINE 0 1 0 0 0 0 0 0 0 1 1INTERNAL MEDICINE 1 0 1 0 0 0 0 0 0 0 1NEPHROLOGY 6 3 3 5 6 5 0 2 1 0 31CHILD NEPHRO. 2 0 0 0 0 0 0 0 0 0 2PULMONOLOGY 9 4 6 2 3 3 1 3* 1 3 32CHILD PULMO. 0 1 0 0 0 1 1 0 0 0 3NEUROSURGERY 0 1 0 0 0 0 0 2 1 0 4NEUROLOGY 4 4 7 6 3 5 7 8 7 3 52NEUROPAEDIATRICS 0 1 0 1 0 0 0 0 0 0 2

OBSTETRICS 0 0 0 0 0 0 0 0 0 0 0OPHTHALMOLOGY 1 0 1 1 0 0 0 0 0 1 3CHILD ONCOLOGY 1 0 0 2 0 0 2 1 0 2 6MEDICAL ONCOLOGY 2 3 7 10 15 7 11 11 15 7 81PAEDIATRICS 1 1 0 0 0 1 0 2 0 0 5PSYCHIATRY 1 0 2 1 0 0 0 0 1 0 5REHABILITATION 1 0 1 0 0 0 1 0 0 0 3RHEUMATOLOGY 2 3 3 1 0 7 2 2 5 5 26TRAUMATOLOGY 1 0 1 0 1 0 0 0 0 0 3CORONARY UNIT 2 0 2 1 1 2 1 0 0 0 9

PRIMARY CARE RESEARCH UNIT 0 0 0 0 0 0 0 0 0 0 0RESEARCH UNIT 0 0 1 0 0 0 0 0 0 0 1

INFECTIOUS DISEASES UNIT 6 2 3 6 8 9 7 6 2 3 49NEONATAL UNIT 0 1 0 0 1 2 1 1 0 0 5

PAEDIATRIC EMERGENCIES PAEDIATRICS 0 0 0 1 0 0 0 0 0 0 1EMERGENCY ROOM 1 0 0 0 1 0 0 0 0 0 2UROLOGY 0 2 2 1 1 0 0 0 2 0 8PRIVATE CENTRES 2 2 0 1 1 2 5 0 0 5 13TOTAL 61 47 60 54 65 64* 55 47* 48 39 540*THE SAME STUDY IS INDEPENDENTLY PERFORMED IN TWO SERVICES

There is a downward trend in the number of studies approved by the CEIC. This reduction corresponds to a lower number of studies that are submitted for evaluation.

ACTIVE CLINICAL STUDIES 2005/2009. DISTRIBUTION BY SERVICE

*Information provided by the Pharmacy Service. Clinical Studies for which Pharmacy has dispensed medication in 2005/2009

SERVICES 2005 2006 2007 2008 2009

Total/Service Total/Service Total/Service Total/Service Total/Service

CARDIOLOGY 2 2% 1 1% 1 1% 2 1% 1 1%

GENERAL SURGERY.-Tx 5 4% 4 3% 4 3% 7 5% 5 4%

DERMATOLOGY 3 2% 2 2% 2 2% 3 2% 0 0%

DIGESTIVE 4 3% 5 4% 5 4% 4 3% 6 4%

ENDOCRINOLOGY 7 6% 7 6% 11 8% 8 5% 7 5%

CHILD ENDOCRINOLOGY 2 2% 1 1% 0 0% 0 0% 1 1%

GYNAECOLOGY 2 2% 2 2% 2 2% 2 1% 0 0%

HAEMATOLOGY 1 1% 5 4% 9 7% 6 4% 5 4%

NEPHROLOGY 10 8% 9 7% 5 4% 8 5% 6 4%

PULMONOLOGY 9 7% 6 5% 9 7% 9 6% 7 5%

NEUROLOGY 14 11% 14 11% 16 12% 19 13% 18 13%

MEDICAL ONCOLOGY 26 21% 30 24% 30 23% 40 27% 47 32, 6%

PSYCHIATRY 0 0% 0 0% 0 0% 1 1% 1 1%

RHEUMATOLOGY 6 5% 8 6% 6 5% 8 5% 8 6%

CORONARY UNIT 4 3% 5 4% 5 4% 5 3% 4 3%

INFECTIOUS DISEASES UNIT 15 12% 15 12% 15 11% 15 10% 13 9%

UROLOGY 1 1% 1 1% 1 1% 1 1% 1 1%

OTHER SERVICES 11 9% 12 10% 11 10% 12 9% 15 10%

TOTAL 123 100 125 100 133 100 150 100 144* 100 * Medication is dispensed to a Primary Care centre in 1 case

Publications

Publicaciones RESEARCH PROJECTS (Public convocations) PROYECTOS DE INVESTIGACIÓN

(Convocatorias públicas) 2005 2006 2007 2008 2009

Active Ingredients Activos 47 59 68 68 120 Financed during the year Financiados en el año 15 17 31 48 45 %Financed/requested %Financiados/solicitados 45 43 44 81 44 Research networks Redes de investigación 11 11 6 6 8 Clinical studies Ensayos clinicos 64 55 47 48 39 Active Ingredients Activos 123 125 133 150 144 Approved during the year Aprobados en el año 64 54 47 48 39 SCIENTIFIC PRODUCTION PRODUCCIÓN CIENTÍFICA Articles / letters in journals Articulos / cartas en revistas 144 154 280 202 204 Articles / letters with sci-fi Artículos / cartas con sci-fi 83 84 146 105 147 Books / Chapters in books Libros / Capítulos de libros 64 47 64 43 97 Doctoral dissertations Tesis doctorales 6 5 5 7 1 Papers / communications Ponencias / comunicaciones 541 635 715 928 846 Courses / events / round tables / conferences Cursos / jornadas / mesas / conferencias 266 242 440 627 570

Summary of the Scientific Activity by Service

resumen de la actividad científica por servicio

2009

JOURNAL ARTICLE

Conference /

Round Table

Book /

Book Chapter / Lette

r

Courses /

Seminars /

Events

THESIS

Speech /

Communicati

on / Poster

Award / WWW /

Scholarship /

Symposium /

Video

SCIENTIFIC PROJECTS

Pathological Anatomy

Anatomía Patológica 8 3 1 5 18

Library Biblioteca 1 8 Biochemistry Bioquímica 2 1 14 Cardiology Cardiología 4 1 1 9 Child Surgery Cirugía Infantil 2 1 15 7 1

Maxillofacial Surgery Cirugía Maxilofacial 3 1 1 11 8 1 2

Plastic Surgery and Major Burns

Cirugía Plástica y Grandes Quemados 2 1 0 13

Thoracic Surgery Cirugía Torácica 1 0

Intensive Care Cuidados Intensivos 3 6 5 7 1

Paediatric Intensive Care ICU

Cuidados Intensivos Pediatría UCI 2 5 18 20

Dermatology Dermatología 10 2 1 22 1 Teaching and Research

Docencia e Investigación 2 9 2

Clinical Documentation

Documentación Clínica 3 12 1 1

Endocrinology Endocrinología 7 2 28 8 11

Child Endocrinology Endocrinología Infantil 6 1 0 39

Infectious Disease Enf Infecciosa 12 5 2 17 28 4 6 Pharmacy Farmacia 2 46 9 Child Gastroenterology

Gastroenterología Infanti 1 0

Genetics Genética 6 1 1 4 11 1 Gynaecology Ginecología 15 7 3 13 100 3 1 Gynaecology / Obstetrics

Ginecología / Obstetricia 0 2

Haematology Hematología 2 4 4 8 41 3 Haemodynamics Hemodinámica 3 2 14 2

Home Hospitalisation Hospitalización a Domicilio 1 1 49 15

Internal Medicine Medicina Interna 8 27 11 11 25 4

Preventive Medicine Medicina Preventiva 1 4 3 7 1

Paediatric Metabolism

Metabolismo Pediatría 1 0 3

Microbiology-Parasitology

Microbiología-Parasitología 1 0 13

Nephrology (7th and 8th) Nefrología (7ª y 8ª) 7 8 2 13 22 Child Nephrology Nefrología Infantil 5 7 6 25 6 3 Neonatology Neonatología 5 8 2 2 15 2 4 Pulmonology Neumología 21 6 0 52 1 Neurosurgery Neurocirugía 2 2 4 4 17 2 Neurology Neurología 17 2 1 0 32 6

Ophthalmology Oftalmología 3 1 2 1 Medical Oncology Oncología Médica 3 4 22 23 1 Oncology-Radiotherapy

Oncología-Radioterapia 2 1

Otolaryngology Otorrinolaringología 3 7 7

Oncologic Paediatrics

Pediatría Oncológica 3 5 1 17 6 6

Psychiatry Psiquiatría 5 3 10 15 1 38 1 2 Radiotherapy Radioterapia 4 5 11 44 0 Rehabilitation Rehabilitación 4 7 48 4 1 Rheumatology Reumatología 13 2 1 3 25 3 Occupational Health Salud Laboral 1 46 5 Traumatology Traumatologia 3 1 26

Research Unit Unidad de Investigación 5 0 5 10

Pain Unit Unidad Del Dolor 0 1 Paediatric Emergencies

Urgencias Pediatría 5 6 11 24 33 1

Child Urology Urología Infantil 1 4 1 1 Total Total 204 107 97 463 1 846 33 68

ACTIVE CLINICAL STUDIES 2002/2007. DISTRIBUTION BY SERVICE*

*Information provided by the Pharmacy Service. Clinical Studies for which Pharmacy has dispensed medication in 2002/2009

SERVICES 2002 2003 2004 2005 2006 2007 2008 2009 Total/Service Total/Service Total/Service Total/Service Total/Service Total/Service Total/Service Total/Service CARDIOLOGY 1 1% 1 1% 2 2% 2 2% 1 1% 1 1% 2 1% 1 1%GENERAL SURGERY.-TxHo 4 3% 6 5% 7 6% 5 4% 4 3% 4 3% 7 5% 5 4%DERMATOLOGY 4 3% 5 4% 3 2% 3 2% 2 2% 2 2% 3 2% 0 0%DIGESTIVE 7 6% 8 6% 6 5% 4 3% 5 4% 5 4% 4 3% 6 4%ENDOCRINOLOGY 11 9% 11 9% 8 7% 7 6% 7 6% 11 8% 8 5% 7 5%CHILD ENDOCRINOLOGY 6 5% 3 2% 4 3% 2 2% 1 1% 0 0% 0 0% 1 1%GYNAECOLOGY 3 3% 1 1% 0 0% 2 2% 2 2% 2 2% 2 1% 0 0%HAEMATOLOGY 2 2% 2 2% 1 1% 1 1% 5 4% 9 7% 6 4% 5 4%NEPHROLOGY 11 9% 8 6% 11 9% 10 8% 9 7% 5 4% 8 5% 6 4%PULMONOLOGY 14 12% 13 10% 8 7% 9 7% 6 5% 9 7% 9 6% 7 5%NEUROLOGY 10 8% 16 12% 16 13% 14 11% 14 11% 16 12% 19 13% 18 13%MEDICAL ONCOLOGY 15 12% 21 16% 21 17% 26 21% 30 24% 30 23% 40 27% 47 33%PSYCHIATRY 3 3% 1 1% 0 0% 0 0% 0 0% 0 0% 1 1% 1 1%RHEUMATOLOGY 8 7% 6 5% 2 2% 6 5% 8 6% 6 5% 8 5% 8 6%CORONARY UNIT 3 3% 4 3% 4 3% 4 3% 5 4% 5 4% 5 3% 4 3%INFECTIOUS DISEASES UNIT 7 6% 8 6% 13 11% 15 12% 15 12% 15 11% 15 10% 13 9%UROLOGY 4 3% 5 4% 3 2% 1 1% 1 1% 1 1% 1 1% 1 1%OTHER SERVICES 8 6% 10 13% 12 9% 11 9% 12 10% 11 10% 12 9% 15 10%TOTAL 121 100 130 100 121 100 123 100 125 100 133 100 150 100 144* 100 * Medication is dispensed to a Primary Care centre in 1 case

OTHER STUDIES/RESEARCH PROJECTS SUBMITTED TO THE CEIC 47

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