ReseaRch Bulletin - Harvard University
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Jan – Feb 2020 RESEARCH BULLETIN Yingzi Yang, PhD, professor of Developmental Biology and associate dean for translational research, received funding from the Orphan Disease Center’s Million Dollar Bike Ride pilot grant program for “Mechanistic and Therapeutic Studies of Fibrous Dysplasia Craniofacial Defects.” Emily Moore, PhD, a postdoctoral fellow in the Yang Lab, is also an investigator on this project. They will focus on fibrous dysplasia (FD), a rare skeletal disorder in which bone-forming cells fail to mature and produce too much fibrous, or connective tissue. They have successfully modeled FD with the novel conditional “knock-in” mouse line they created. Unpublished preliminary results show that Yap protein, which can cause various cancers when increased in expression, was upregulated by GαsR201H expression in cranial bone development. Genetic upregulation of Yap activities also inhibited cranial bone formation. For this study, they will determine Yap activity in the cranial and maxillary bone and test whether inhibiting Yap activities with or without Wnt inhibition in the FD mutant may offer a novel therapeutic opportunity to reduce fibrotic overgrowth and promote bone ossification in the cranial and maxillary bones. Brittany Seymour, DDS, MPH, assistant professor of Oral Health Policy and Epidemiology, received funding from the ADEAGies Foundation, which is the philanthropic arm of the American Dental Education Association. Seymour is the principal investigator for “The Global Health Learning Helix for Dental Educators.” Seymour has also taken on a new role at HSDM directing the DMD global health curriculum. Seymour is photographed at Las Cruces Research Station and Wilson Botanical Garden campus in rural southern Costa Rica, where she teaches the field-based component of this curriculum. This project stems from the concept of a spiral curriculum, in which topics are repeatedly reinforced throughout the academic program. The two strands of the Helix represent didactic classroom learning and experiential learning in global communities, while common competency themes form the backbone. The Helix model is collaboratively developed, refined, and taught with HSDM’s project partner, the Inter American Center for Global Health (CISG) and communities served by CISG in rural Costa Rica. CISG is the first global health education hub in Latin America and focuses on transformative global health educational programming with its institutional partners. Helix competency themes include the social determinants of health, the global burden of disease, the integration of oral health and primary care and oral health as part of overall health, comparative health systems and policies and impact on their respective communities, common risk factors for oral and other non-communicable diseases, community empowerment and shared solutions for health improvement, among others. These competencies will be reinforced and evaluated throughout the curriculum, beginning with a didactic foundation at HSDM, reiterated through practical experience on site with CISG in Costa Rica, and strengthened through guided reflection and repeated didactic learning at HSDM. This educational model will catalyze curriculum growth for dental students interested in global health and will expand the cadre of future global oral health leaders.
Transcript of ReseaRch Bulletin - Harvard University
Jan – Feb 2020 ReseaRch Bulletin
Yingzi Yang, PhD,professor of Developmental Biology and associate dean for translational research, received funding from the Orphan
Disease Center’s Million Dollar Bike Ride pilot grant program for “Mechanistic and Therapeutic Studies of Fibrous Dysplasia Craniofacial Defects.” Emily Moore, PhD, a postdoctoral fellow in the Yang Lab, is also an investigator on this project.
They will focus on fibrous dysplasia (FD), a rare skeletal disorder in which bone-forming cells fail to mature and produce too much fibrous, or connective tissue. They have successfully modeled FD with the novel conditional “knock-in” mouse line they created. Unpublished preliminary results show that Yap protein, which can cause various cancers when increased in expression, was upregulated by GαsR201H expression in cranial bone development. Genetic upregulation of Yap activities also inhibited cranial bone formation.
For this study, they will determine Yap activity in the cranial and maxillary bone and test whether inhibiting Yap activities with or without Wnt inhibition in the FD mutant may offer a novel therapeutic opportunity to reduce fibrotic overgrowth and promote bone ossification in the cranial and maxillary bones.
Brittany Seymour, DDS, MPH, assistant professor of OralHealth Policy and Epidemiology, received funding from the ADEAGies Foundation, which is the philanthropic arm of the American Dental Education Association. Seymour is the principal investigator for “The Global Health Learning Helix for Dental Educators.” Seymour has also taken on a new role at HSDM directing the DMD global health curriculum.
Seymour is photographed at Las Cruces Research Station and Wilson Botanical Garden campus in rural southern Costa Rica, where she teaches the field-based component of this curriculum.
This project stems from the concept of a spiral curriculum, in which topics are repeatedly reinforced throughout the academic program. The two strands of the Helix represent didactic classroom learning and experiential learning in global communities, while common competency themes form the backbone.
The Helix model is collaboratively developed, refined, and taught with HSDM’s project partner, the Inter American Center for Global Health (CISG) and communities served by CISG in rural Costa Rica. CISG is the first global health education hub in Latin America and focuses on transformative global health educational programming with its institutional partners. Helix competency themes include the social determinants of health, the global burden of disease, the integration of oral health and primary care and oral health as part of overall health, comparative health systems and policies and impact on their respective communities, common risk factors for oral and other non-communicable diseases, community empowerment and shared solutions for health improvement, among others.
These competencies will be reinforced and evaluated throughout the curriculum, beginning with a didactic foundation at HSDM, reiterated through practical experience on site with CISG in Costa Rica, and strengthened through guided reflection and repeated didactic learning at HSDM. This educational model will catalyze curriculum growth for dental students interested in global health and will expand the cadre of future global oral health leaders.
2 Research Bulletin • January – February 2020 • Harvard School of Dental Medicine
PuBlicationsDeveloPmental BiologyCho Y, Li S, Wang X, Zhu J, Zhuo S, Han Y, Yue T, Yang Y, Jiang J. CDK7 regulates organ size and tumor growth by safeguarding the Hippo pathway effector Yki/Yap/Taz in the nucleus. Genes and Development 2019; Dec 19.
Davis K, Mountain R, Pickett O, Den Besten P, Bidlack F, Dunn E. Teeth as potential new tools to measure early-life adversity and subsequent mental health risk: An interdisciplinary review and conceptual model. Biological Psychiatry 2019; Dec 11.
Gan W, Dai X, Dai X, Xie J, Yin S, Zhu J, Wang C, Liu Y, Guo J, Wang M, Liu J, Hu J, Quinton R, Ganem N, Liu P, Asara J, Pandolfi P, Yang Y, He Z, Gao G, Wei W. LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control. Nature Cell Biology 2020 Feb 3.
Hussein I, Al Halabi M, Kowash M, Salami A, Ouatik N, Yang Y, Duggal M, Chandwani N, Nazzal H, Albadri S, Roberts A, Al-Jundi S, Nzomiwu C, El Shahawy O, Attaie A, Mohammed O, Al-Sane M. Use of the Hall technique by specialist paediatric dentists: a global perspective. British Dental Journal 2020;228(1):33-38.
Muruganandan S, Fan X, Dhal S, Nayak N. Development of a 3D tissue slice culture model for the study of human endometrial repair and regeneration. Biomolecules 2020;10(1).
O’Keefe R, Tuan R, Lane N, Awad H, Barry F, Bunnell B, Colnot C, Drake M, Drissi H, Dyment N, Fortier L, Guldberg R, Kandel R, Little D, Marshall M, Mao J, Nakamura N, Proffen B, Rodeo S, Rosen V, Thomopoulos S, Schwarz E, Serra R. American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies – Seond Publication. Journal of Orthopaedic Research 2020; Jan 29.
Volloch V, Olsen BR, Rits S. Precursor-independent overproduction of beta-amyloid in Alzheimer’s Disease.: Mitochondrial dysfunction as possible initiator of asymmetric RNA-dependent βAPP mRNA amplification. An engine that drives Alzheimer’s Disease. Annals of Integrative Molecular Medicine 2019;1(1):61-74.
oRal meDicine, infection anD immunity Alamir A, Hakami Y, Alabsi F, Halboub E, Bajonaid A. Potential myogenous temporomandibular disorders following Iatrogenic occlusal disturbance. Journal of Contemporary Dental Practice 2019;20(10):1138-1140.
Alves C, Treister N, Ribeiro A, Brandão T, Tonaki J, Lopes M, Rivera C, Santos-Silva A. Strategies for communicating oral and oropharyngeal cancer diagnosis: Why talk about it? Oral Surgery Oral Medicine Oral Pathology Oral Radiology 2019; Nov 28.
Attaia D, Ting S, Johnson B, Masoud M, Friedland B, Abu E, Fotouh M, Abu El Sadat S. Dose reduction in head and neck organs through shielding and application of different scanning parameters in cone beam computed tomography: An effective dose study using an adult male anthropomorphic phantom.Oral Surgery Oral Medicine Oral Pathology Oral Radiology 2019; Nov 28.
Clem D, Lynch S, Nevins M. Biologics in regeneration: What is their impact on periodontal and dental implant surgery? Compendium of Continuing Education in Dentistry 2020;41(1):12-15.
Helmi M, Goodson J, Hasturk H, Natto Z. Annual alveolar bone loss in subjects with cardiovascular disease adjusting for associated systemic diseases and risk factors: a retrospective study. BMC Oral Health 2020; 30;20(1):28.
aWaRDsRocio fuente Perez, PhD, postdoctoral fellow in developmental biology in the Ionescu Lab, received the Best Basic Science Award from The Royal Academy of Medicine and Surgery for her project “longitudinal growth, morphology and Dynamics of growth cartilage, osseous structure
and Phosphorus metabolism in the hyp mouse – the effect of several therapeutic strategies for X-linked hypophosphatemic Patients.” Fuente Perez continues to work on the generation of a new approach for the treatment of X-linked hypophosphatemia in children.
george e. Bork, DDs, MMSc orthodontics candidate, has been selected as a finalist for the American Association of Orthodontists (AAO) Resident Scholar Award for “effect of a novel universal temporary anchorage Device (taD) Placement guide on Root Proximity, Root Damage and taD
angulation” (research mentor is Dr. Mohamed I. Masoud).
anvita maharishi, BDs, ms, MMSc prosthodontics candidate, has been selected by the American Prosthodontics Society for 3rd place in the graduate research competition for “light transmission and Wear of translucent Zirconia after conventional and fast sintering
cycle”(research mentors are Dr. John Burgess and Dr. Edward McLaren at the University of Alabama).
Research Bulletin • January – February 2020 • Harvard School of Dental Medicine 3
Liberton D, Verma P, Almpani K, Fung P, Mishra R, Oberoi S, Senel F, Mah J, Huang J, Padwa B, Lee J. Craniofacial analysis may indicate co-occurrence of skeletal malocclusions and associated risks in development of cleft lip and palate. Journal of Developmental Biology 2020; Jan 28;8(1).
Patel N, Ji Y, Donoff R. Clinical productivity and Medicare payments among female and male oral and maxillofacial surgeons. Journal of Oral and Maxillofacial Surgery 2020; Jan 7.
Wu B, Jazayeri H, Lee K, Khavanin N, Dorafshar A, Peacock Z. Characterizing craniomaxillofacial injuries in American professional sports leagues. Journal of Oral and Maxillofacial Surgery 2019; Dec 3.
oRal health Policy anD ePiDemiologyBahdila D, Aldosari M, Abdullah A, Nelson J, Hegazi F, Badamia R, Alhazmi H, Chandel T, Odani S, Vardavas C, Agaku I. Cocaine, polysubstance abuse and oral health outcomes, NHANES 2009-2014. Journal of Periodontology 2020; Jan 10.
Elani H, Kawachi I, Sommers B. Changes in emergency department dental visits after Medicaid expansion. Health Services Research 2020; Jan 15.
Karhade D, Middleton J, Simon L. Gender differences in academic productivity and advancement among pediatric dental faculty. Pediatric Dentistry 2019;15;41(6):451-454.
Thomson W, He S, Elani H. Self-report oral health and disease experience among adults in China and NZ. Clinical Oral Investigation 2019;23(5):2123-2128.
Yu A, Lambert R, Alvarado J, Faerron Guzman C, Seymour B. Integrating competency-based didactic and experiential global health learning for dental students: The Global Health Learning Helix Model. Journal of Dental Education 2019; Dec 9.
RestoRative DentistRy anD BiomateRials sciencesBowley J, Lee P, Lai W. Axial wall angulation for rotational resistance in a theoretical-maxillary premolar model. Clinical & Experimental Dental Research 2019;5(6):638-47.
Jang J, Lee S, Lee J. Considerations in the replacement of over-retained primary teeth with implant restorations in the esthetic zone: A case report. Journal of Esthetic and Restorative Dentistry 2020; Jan 30.
Schoenbaum T, Guichet D, Jang J, Kim Y, Wadhwani C. Clinician preferences for complete-arch fixed implant-supported prostheses: Survey of the membership of the Pacific Coast Society for Prosthodontics. Journal of Prosthetic Dentistry 2020; Jan 17.
Yoon S, Oh K, Lee S, Han J, Yoon H. Tissue surface adaptation of CAD-CAM maxillary and mandibular complete denture bases manufactured by digital light processing: A clinical study. Journal of Prosthetic Dentistry 2020; Jan 8.
multi-DePaRtmentalChoi S, Sima C, Pandya A. Impact of treating oral disease on preventing vascular diseases: A model-based cost-effectiveness analysis of periodontal treatment among patients with type 2 diabetes. Diabetes Care 2019; Dec 27.
Jamjoom F, Doliveux S, Rousson D, Friedland B, Hamilton A. A modified implant surgical guide for the administration of maxillary nerve block anesthesia intraorally via the greater palatine foramen. Journal of Medical Insight 2019; 34(5):1254-59.
Salem D, Alsihiri M, Friedland B. Volumetric analysis of allogenic and xenogenic bone substitutes used in maxillary sinus augmentations utilizing cone-beam CT; A prospective randomized pilot study. Journal of Medical Insight 2019;34(4):920–926.
Idelevich A, Sato K, Avihai B, Nagano K, Galien A, Rowe G, Gori F, Baron R. Both NPY- and CART-expressing neurons increase energy expenditure and trabecular bone mass in response to AP1 antagonism, but have opposite effects on bone resorption. Journal of Bone and Mineral Research 2020; Jan 29.
Kao R, Curtis D, Kim D, Lin G, Wang C, Cobb C, Hsu Y, Kan J, Velasquez D, Avila-Ortiz G, Yu S, Mandelaris G, Rosen PS, Evans M, Gunsolley J, Goss K, Ambruster J, Wang H. American Academy of Periodontology best evidence consensus statement on modifying periodontal phenotype in preparation for orthodontic and restorative treatment. Journal of Periodontology 2020; Jan 13.
Kuwajima Y, Ishida Y, Lee C, Mayama H, Satoh K, Ishikawa-Nagai S. 3D digital analysis of magnetic force-driven orthodontic tooth movement. Heliyon 2019;5(11):e02861.
Matsubara T, Yaginuma T, Addison W, Fujita Y, Watanabe K, Yoshioka I, Hikiji H, Maki K, Baron R, Kokabu S. Plectin stabilizes microtubules during osteoclastic bone resorption by acting as a scaffold for Src and Pyk2. Bone 2019;132:115209.
Nguyen V, Flanagan D, Syrbu J, Nguyen T. Socket shield technique used in conjunction with immediate implant placement in the anterior maxilla: A case series. Clinical Advances in Periodontics 2019; Dec 19.
Piet J, Adamo S, Hu D, Baron R, Shefelbine S. Marrow aspiration in aged mice: intramedullary osteogenesis, reduced mechano-adaptation, increased marrow fat. Connective Tissue Research 2019; Dec 22:1-15.
Rao N, Villa A, More C, Jayasinghe R, Kerr A, Johnson N. Oral submucous fibrosis: a contemporary narrative review with a proposed inter-professional approach for an early diagnosis and clinical management. Journal of Otolaryngology Head & Neck Surgery 2020;49(1):3.
Sandhu S, Sankar V, Villa A. Bleeding risk in thrombocytopenic patients after dental extractions: a retrospective single-center study. Oral Surgery Oral Medicine Oral Pathology Oral Radiology 2020; Jan 2.
Van Dyke T, Sima C. Understanding resolution of inflammation in periodontal diseases: Is chronic inflammatory periodontitis a failure to resolve? Periodontology 2000 2020;82(1):205-213.
Villa A, Sonis S. An update on pharmacotherapies in active development for the management of cancer regimen-associated oral mucositis. Expert Opinion on Pharmacotherapy 2020; Jan 28:1-8.
oRal anD maXillofacial suRgeRy Bouloux G, Aghaloo T, Campbell J, Chou J, Edwards S, Kademani D, Reese D, Cillo J, Dodson T, Peacock Z. Proceedings from the Clinical and Scientific Innovations in Oral and Maxillofacial Surgery Conference 2019. Journal of Oral and Maxillofacial Surgery 2019; Nov 20.
Buch K, Peacock Z, Resnick C, Rothermel H, Kaban L, Caruso P. Regional differences in temporomandibular joint inflammation in patients with juvenile idiopathic arthritis: a dynamic post-contrast magnetic resonance imaging study. International Journal of Oral and Maxillofacial Surgery 2020; Jan 31.
Hakim M, Guastaldi F, Liapaki A, Ahn D, Mueller M, Troulis M, McCain J. In vivo investigation of temporomandibular joint regeneration: Development of a mouse model. International Journal of Oral and Maxillofacial Surgery 2020; Jan 8.
Jazayeri H, Ganjawalla K, Lee K, Akbari M, Chuang S, Tannyhill R. Are industry payments associated with the level of evidence in oral and maxillofacial surgery? Journal of Oral and Maxillofacial Surgery 2019; Dec 13.
Jazayeri H, Ganjawalla K, Wu B, Tannyhill R. Is there a link between funding and findings in oral and maxillofacial surgery? Journal of Oral and Maxillofacial Surgery 2019; Dec 4.
4 Research Bulletin • January – February 2020 • Harvard School of Dental Medicine
professor donald b. giddon, dmd, phd annual lecture in behavioral
medicine and dentistry
Dr. Richard Watt
april 7, 2020 – hsdm reb auditorium
9:00–10:00 am lecture 12:00–1:00 pm panel discussion
Dr. Richard Watt is a professor of Dental Public health in the Department of epidemiology and Public health, university college london, and Director of Research for central north West london nottinghamshire healthcare foundation trust. his research focuses on the social determinants of oral health inequalities and the development and evaluation of health improvement interventions.
The Professor Donald B. Giddon, MD, PhD Annual Lecture in Behavioral Medicine and Dentistry was established through the Harry Rothman Foundation, colleagues, friends, and family in honor of Dr. Giddon in 1980. Giddon is professor emeritus of Developmental Biology at HSDM, clinical professor emeritus of community health at Brown University School of Medicine, and attending physician at New York University Hospital. Giddon is a 1959 DMD graduate from HSDM. The first Giddon Lecture was held in 2008 featuring Dr. Lois Cohen as the speaker.
A PuBLiCATion oF THE oFFiCE oF RESEARCH malcolm Whitman, PhD Associate Dean for Basic Science
yingzi yang, PhD Associate Dean for Translational Research
Dawn m. Decosta Editor and Layout
heather m. Denny Editing
lia sgourakes Editing
ashley simmonsEditing
QuESTionS/CoMMEnTS?
HSDM Office of Research188 Longwood Avenue, REB 404Boston, Massachusetts [email protected]
save the Dates science speaker series• March 12, 2020 Dr. matthew greenblatt, Cornell
• April 16, 2020 Dr. tamara alliston, UCSF
• May 14, 2020 Dr. catherine mccusker, UMASS
hsdm student research day• April 7, 2020 9:00 am –3:00 pm
