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Research activity survey January 2015

Report outline complied by;

Professors Rik Cheston and Yoav Ben-Shlomo (co-leads Research workstream),

Dr Jude Hancock (Dementia HIT coordinator),

and

Clive Lambert (Dementia HIT Project Support Manager).

With assistance from;

Ailis Campbell (Management Assistant Bristol Health Partners)

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Contents

Page

Executive summary 3

Background 4

Response to survey 4

Research priorities for the HIT 4

Research activity – grants active on the 1st September 2014 5

Research activity - outputs 5

Research projects active on the 1st September 2014 6

Recently completed projects 9

PhD students 9

Publications 10

Peer review Publications (2012) 10

Peer review Publications (2013) 10

Peer review Publications (2014) 13

Books 15

Book chapters 15

In press 15

Under review 16

Conference presentations 17

Oral 17

Poster 19

Supervision of students 20

Dementia-related teaching 21

Attendance at training events 23

Conference attendances for networking (not presenting) 23

Dementia-related teaching, workshops or training events ran in 2013/2014 23

Appendix A 24

Appendix B 28

Appendix C 29

Appendix D 30

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Executive summary

One of the aims of the Bristol Dementia HIT is to increase the amount of dementia research

being conducted locally. In order to establish a baseline level of research, in the spring of

2013, the research committee of the HIT carried out a survey of dementia research. The

results indicated that 33 projects were in progress, with a combined grant income of

£4,623,410.

This survey was repeated in the autumn of 2014 and indicated 51 projects were in progress,

with a grant income of £12,130,156. This suggests that in the 18 months between the two

surveys, there has been a significant increase in both the amount of research being

undertaken and the quality of this work (as judged by the increase in external funding).

In addition to the project information, the survey for the first time also collected data about

publications, presentations, and teaching. Findings indicated that 56 peer-reviewed

publications had been published in the preceding year, with a further 5 in press, and 9 under

review. In addition, 32 oral and 15 poster presentations had been completed. There were 6

current PhD students, and many other BSc and MSc students being supervised.

As a subsidiary aim, it is hoped that by publishing this research on the Bristol Health Partners

web-site will help to raise the profile of dementia research in the Bristol, Bath and Swindon.

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Background

In the spring of 2013, the Dementia HIT research stream undertook a survey of research

activity within the HIT. This led to a list of research activity being compiled (see Appendix A)

which consisted of responses from roughly 20 individuals.

In February 2014, the Dementia HIT research meeting agreed that a follow-up survey of

research activity should be undertaken. In addition to collecting information from the 2013

survey, this follow-up survey also looked at other forms of research activity, as well as asking

respondents to provide ideas for future HIT-related research. However, by this point, the

nature of the meeting had changed, and as well as researchers from the Bristol area, the

meeting now included dementia researchers from RICE (in Bath) and Kingshill (in Swindon).

The survey was distributed via e-mail on the 31st March 2014, with a request to send

responses by 22nd April 2014 (Appendix B) inviting participants to complete a short survey

(Appendix C). Due to a limited response to the initial request, a second email was sent on

24th October 2014 requesting further information. the response rate to this second request

was higher, and respondents were contacted individually in November 2014 to ensure

accuracy of data.

The project team responsible for circulating the 2014 survey was Dementia HIT co-ordinator

(Dr Jude Hancock), Dr Liz Coulthard and Dr Sarah Cullum (HIT leads), Prof Richard Cheston

(co-chair of the Dementia HIT research committee), Lauren Dennis and Ailis Campbell

(Bristol Health Partners Management Assistants), Clive Lambert (Dementia HIT

administrator) on behalf of the research workstream of the Dementia HIT.

Response to survey

The research survey was sent to 75 researchers known to the HIT and who worked for the

HIT’s partner organisations. In addition, 320 other staff who had been identified as having an

interest in research or service evaluation were also sent the survey and invited to suggest

areas for future research. The breakdown of organisations that staff worked for included;

Avon and Wiltshire Mental Health Partnership, Alzheimer’s Society, Bristol CCG, Bristol

Community Health, Dementia Action Alliance, North Bristol Trust, South Gloucestershire

CCG, South Gloucestershire Council, University Hospital Bristol, Volunteer Bristol.

In April 2014, 21 responses were received. After the prompt in October 2014 a further 31

responses were received. The majority of responses were received from research staff (n =

46). The difficulties with using email to compile responses to this survey suggests a new

mechanism to record HIT-related research activity is required for monitoring of future

research activity.

Research priorities for the HIT

As part of the research survey, ideas for further research were requested. These research

ideas were reviewed on the 13th May 2014 by the two research stream co-chairs (Richard

Cheston and Yoav Ben-Sholmo) and by one of the leads of the Dementia HIT (Liz Coulthard).

This review of research ideas was used to inform the development of research priorities for

the Dementia HIT (see Appendix D).

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On the 19th September 2014 two research outlines, based on these research priorities, were

submitted to the first call for CLAHRCWest research support. One application led by Rik

Cheston was titled ‘targeting post-diagnostic psychosocial interventions for people affected

by dementia within a stepped care model’ and the second application led by Dr Sarah Cullum

was titled ‘Understanding the causes and reasons behind avoidable hospital admissions in

people living with dementia: bringing together national and local data.’ Both these projects

were successful and are currently being supported by CLAHRCWest.

Research activity – grants active on the 1st September 2014

In all, 49 projects were active on the 1st September 2014, compared to just 33 projects were

in progress on the 1st April 2013. In defining what does and does not constitute a “dementia

research project” we have adopted a liberal approach, and have included some projects (e.g.

the SPHERE project) which is not primarily aimed at people affected by dementia, but which

may nevertheless still have important implications for the care or cure of people affected by

dementia. In addition, the survey had now increased in size, so that as well as covering

researchers in Bristol, the two memory clinics at Bath (RICE) and Swindon (Kingshill) were

now also involved.

It is hard to estimate the overall worth of these projects, partly because we do not have this

information for all of the projects and partly because many projects are multi-site and where

we do have a figure about the project value, this is for the overall amount, rather than for

the Bristol site. In addition, we have decided to remove the SPHERE project from our

calculation not only because it does not primarily focus on people affected by dementia, but

also that its large size (£12,000,000) would render any comparison with 2013 meaningless.

However, despite these caveats, the grant income for the 1st April, 2013 was £4,623,410,

while for the 1st October 2014 it was £12,130,156.

This suggests that in the 18 months between the two surveys, there has been a significant

increase in both the amount of research being undertaken and the quality of this work, as

judged by the increase in external funding. Although the enlarged nature of the 2014 survey

means that it is difficult to draw direct comparisons, the scale of the increase in both grant

activity and funding does point to an increase in dementia research activity over 18 months.

Research activity - outputs

Respondents were asked to list research outputs over the previous year. In 2013, 27 peer

review journal papers were listed, with 24 in the ten months of 2014 up until the 1st

October. In addition a book, and several book chapters have also been produced. Thirty-two

oral conference presentations were provided during 2013 and 2014, and 15 poster

presentations. A list of dementia-related teaching and training is also provided.

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Research projects active on the 1st September 2014

Boche, D., Holmes, C., Love, S., Nicoll, J., Perry, H. Investigation into the impact of systemic

inflammation due to infection on microglial phenotype and its contribution to Alzheimer’s

disease neuropathology. £316,261.24, ARUK, 01/01/2013 – 31/12/2016.

Caldwell, M., Love, S., Coulthard, E., Uney, J., Kehoe, P. Use of IPS technology to model

Alzheimer's disease in vitro: assessing the influence of disease status and APOE genotype on

basal forebrain-type neurons derived from skin fibroblasts. £216,409, BRACE, 01/03/2012 –

28/02/2014.

Cheston, R. The LivDem study: conducting a literature review of Psychotherapy with people

affected by dementia, and consulting with the public. £16,000, AWP, 1/6/14 – 31/3/15.

Cheston, R., Sedikides, C., & Christopher, G. Mnemic neglect in people affected by

Alzheimer’s disease: replicating and extending findings from Experimental Social Psychology,

£52, 473, Alzheimer Society, 18 month study.

Cheston, R. Gray, R. and colleagues . A preliminary comparison inpatient dementia wards

which use Protected Engagement Time, with other wards delivering standard care alone.

£249, 843, NIHR – RFPB, ends 31/5/2015.

Conway, M.E. and Paul, C. The role of increased hBCATm in the endothelial cells of patients

with Alzheimer’s disease, £42 000, BRACE PhD studentship , 2014-2017.

Conway, M.E. A panel of biomarkers for the detection of Alzheimer’s disease, £28,359, UWE,

SPUR award, 2013-2014.

Conway, M.E. The brain specific hBCAT proteins and redox partners as biomarkers of

Alzheimer’s disease and other neurodegenerative conditions, £60,000, UWE, PhD

studentship, 2012-2015.

Conway, M.E. and Paul, C. Understanding the role of dysregulated autophagy in Alzheimer’s

disease, £78,000, BRACE PhD studentship, 2012-2015.

Coulthard, E. (PI). Hippocampal changes in early Alzheimer's disease: A multimodal Magnetic

Resonance Study, £49,999, ARUK (on NIHR portfolio), 1/9/13 – 1/9/15.

Coulthard, E. (local PI). Genetic analysis of early onset dementias, NIHR (on NIHR portfolio),

ends 30/4/15.

Coulthard, E. (local PI). Euro HD Registry 3 (REGISTRY – a study by the European Huntington’s

Disease Network [EHDN]), Cure Huntington's Disease Network (Inc) CHDI USA (NIHR

portfolio), ends 01/01/2030.

Coulthard, E. (local PI). ENGAGE-HD: Activity Engagement in Huntington's Disease

(Supporting Activity Engagement in People with Huntington’s disease: A Phase II Evaluation),

National Institute of Social Care and Health Research (NIHR portfolio), ends 31/03/16.

Creavin, S. TIMeLI: Towards Improving the Diagnosis of Memory Loss in General Practice.

£19,705 until March 2015 from NHS Bristol Clinical Commissioning group. £9,971 from

School of Primary Care Research.

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Craddock, I. (PI) SPHERE: a Sensor Platform for Healthcare in a Residential Environment.

EPSRC Interdisciplinary Research Collaboration (IRC) fund, £12,000,000, ends 2019.

Holmes, R. Development and Implementation of Neuroimaging Analysis in Dementia.

NIHR/HEE fellowship (reference NIHR-HCS-P13-04-003) 01/03/2014 – 03/2018.

Holmes, R. Improvements in PET/SPECT Anthropomorphic Phantoms Using 3D Printing.

£5,600, Institute of Physics and Engineering in Medicine Innovation and Research Award.

Jones, R., & Noonan, K. Improving the experience of Dementia and Enhancing Active life:

Living well with dementia’ (IDEAL), £4, 000,000, ESRC and NIHR, 01/08/2014 – 01/08/2019.

Kauppinen, R.A., Coulthard, E., Kehoe, P., & Love, S. Multi-transmit capability for 3T MRI

scanner for high resolution MRI. ARUK, £30,000, 01/03/2014 – 28/02/2015.

Kehoe, P.G., Ben-Shlomo, Y., Montgomery, A., Blair, P., Passmore, A., Wilkinson, I.,

Coulthard, E., & Kauppinen, R. Reducing pathology in Alzheimer’s Disease through

Angiotensin TaRgeting — The RADAR Trial, £1,944,906, NIHR-MRC (on NIHR portfolio),

01/01/2013 – 31/12/2016.

Kehoe, P., & Paton J.F.R. Angiotensin II in the brain: the link between dementia and

hypertension. £87,200, Medical Research Council PhD scholarship, 01/10/2011 –

30/09/2015.

Kehoe, P., Love, S., Coulthard, E., & Miners, S. Alzheimer's Brain Bank UK: Brains for

Dementia Research 5-year renewal (Bristol component). £497,897, Jointly funded by

Alzheimer's Research UK and the Alzheimer's Society, 01/04/2013 – 31/03/2018.

Kingshill Research Centre. A Prospective, Randomized, Double-Blind, Placebo-Controlled,

Phase 2 Efficacy and Safety Study of Oral ELND005 for Treatment of Agitation and

Aggression in Patients With Moderate to Severe Alzheimer’s Disease. Sponsor: ELAN.

Kingshill Research Centre. Effect of Passive Immunization on the Progression of Mild

Alzheimer’s Disease: Solanezumab (LY2062430) versus Placebo. LZAX.

Kingshill Research Centre. A Randomised, Placebo Controlled, Parallel-Group, Double Blind

Efficacy and Safety Trial of MK8931 in Subjects with Mild to Moderate Alzheimer's Disease.

Sponsor: Merck.

Kingshill Research Centre. An Efficacy and Safety Trial of MK-8931 in Subjects with Amnestic

Mild Cognitive Impairment (aMCI) due to Alzheimers Disease (AD). Sponsor: Merck.

Kingshill Research Centre. A Phase 3, randomized, double-blind, placebo-controlled, parallel-

group, multicentre efficacy and safety study of Gantenerumab in patients with mild

Alzheimer's Disease. Sponsor: Roche.

Kingshill Research Centre. Randomized, double-blind, placebo-controlled, parallel-group, 12-

month trial of Leuco-methylthioninium (bi(hydromethanesulfonate) in subjects with mild to

moderate Alzheimer’s Disease. Sponsor: TauRx therapeutics.

Kingshill Research Centre. A randomized, double-blind, placebo-controlled, parallel-group,

multicentre, phase II study to evaluate the efficacy and safety of MABT5102A in patients

with mild to moderate Alzheimer’s Disease. Sponsor: Genetech.

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Love, S., & Kehoe, P. Evaluating the relationship between ischaemia and neurodegeneration

in post-mortem brain tissue. £263,640, ARUK, 01/10/2011 – 30/09/2015.

Love, S., Kehoe, P., & Paton, J.P.R. ET-1 mediated reduction of cerebral blood flow in

Alzheimer’s disease: therapeutic potential of zibotentan. £526,622, MRC/ Astra Zeneca,

01/04/2013 – 31/03/2017.

Love, S., Ansorge, O., Attems, J., Costelloe, C., Hortobagyi, T., Ironside, J., Kalaria, R., Kehoe,

P., King , A., Mann, D., Neal, J., Skrobot, O. Assessment of neuropathological changes

associated with vascular dementia: validation of a consensus approach. £93,151, ARUK,

01/03/2013 – 28/02/2015.

Passmore, P., O’Sullivan, M., Kehoe, P., Holmes, C., Bath, P., Stewart, R., Ballard, C., Jones, R.,

Coulthard, C., Corbett, A., Thomas, A., Wallach, S., Connolly, P., & Canning, R. A randomized

controlled trial of calcium channel blockade (CCB) with amlodipine for the treatment of

subcortical ischaemic vascular dementia (SIVD). £2,763,650, Alzheimer’s Society/British

Heart Foundation, 01/06/2013 – 31/01/2017.

Pennington, C., Coulthard, E., Adams, D. Detecting the earliest hippocampal changes in

Alzheimer's disease – extension to include patients with behavioural variant frontotemporal

dementia. (Neuropsychology Masters project), UoB, 12 months, £1,000.

R.I.C.E. Observational study of resource use and cost of Alzheimer’s disease in Europe (The

GERAS Study), Sponsor: Lilly, 18 month observational study to assess the burden of caring

for someone with Alzheimer’s disease.

R.I.C.E. Addendum to Observational study of resource use and cost of Alzheimer’s disease in

Europe, Sponsor: Lilly. (This is an extension to the GERAS study).

R.I.C.E. A Randomized, Double-Blind, Placebo controlled, Parallel Group, Multicentre, Phase

II Study to Evaluate the Efficacy and Safety of MABT5102A in Patients with Mild to Moderate

Alzheimer’s Disease Extension study. Sponsor: Lilly (This is an extension study).

R.I.C.E. Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, 12-Month Trial of

Leucometh-ylthioninium bis (hydromethanesulfonate) in Subjects with Mild to Moderate

Alzheimer’s Disease. Sponsor: TauRx

R.I.C.E. An Open-Label, Extension Study of the Effects of Leuco-methylthioninium bis

(hydromethanesulfonate) in Subjects with Alzheimer’s Disease or Behavioral Variant

Frontotemporal Dementia. Sponsor: TauRx (This is an extension study).

R.I.C.E. A Prospective, Randomized, Double-Blind, Placebo-Controlled, Phase 2 Efficacy and

Safety Study of Oral ELND005 for Treatment of Agitation and Aggression in Patients With

Moderate to Severe Alzheimer’s Disease. Sponsor: Elan Pharma International Limited.

R.I.C.E. Effect of Passive Immunization on the Progression of Mild Alzheimer’s Disease:

Solanezumab (LY2062430) Versus Placebo. Sponsor: Lilly

R.I.C.E. A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, 26-Week, Phase 3

Study of Two Doses of EVP-6124 or Placebo in Subjects with Mild to Moderate Alzheimer’s

Disease Currently or Previously Receiving an Acetylcholinesterase Inhibitor Medication.

Sponsor: EnVivo Pharmaceuticals Inc.

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R.I.C.E. Goal Orientated Cognitive Rehabilitation in Early-Stage Alzheimer’s Disease: Multi-

Centre Single-Blind Randomised Control Trial (GREAT). £2,430,568, NIHR Health Technology

Assessment (NIHR portfolio), ends 30/09/2015.

R.I.C.E. Investigation of screening tools for amnestic mild cognitive impairment (a-MCI).

£248,000, NIHR- RfPB, 01/09/2012 – 01/09/2015.

R.I.C.E. Improving the experience of dementia and enhancing active life: living well with

dementia. £4,000,000, ESRC/NIHR dementia initiative, 30/06/2016.

R.I.C.E. Charting Techniques for object-name relearning in Semantic Dementia. £9,100,

Gwyneth Forrester Trust. 2011-2014.

Sharma, K. Effects of caffeine in Dementia with Lewy Bodies. No funding attached, time was

funded from Dr Coulthard’s research fund, which occurs on an ad hoc basis.

Shoemark, D., & Allen, S. Developing a bacterial biomarker to select Alzheimer’s patients for

whom oral bacteria may be contributing to AD progression. £59,009, BRACE, 01/09/2013-

31/08/2014.

Williams, R.J., & Wonnacott, S. Activity dependent processing of APP in the ageing brain.

£65,000, BBSRC DTG, 10/10 – 09/14.

Recently completed projects

Foster, L. Family Work in dementia. AWP RCF grant.

Kehoe, P., & Martin, R . Exploring ‘Polypill’ options to treat dementia. £19,000, University

Hospitals Bristol NHS Trust Flexibility and Sustainability Fund Pump Priming grant,

01/04/2012 – 30/09/2012.

Leonards, U., Haworth, J., Tales, A., & Burn, J. Identifying the causes for increased falls in

dementia – a pilot study in healthy older and younger volunteers. BRACE. 2013-2013.

Love, S., Kehoe, P., Paton, J. Influence of amyloid β peptide (Aβ) on ECE-mediated regulation

of cerebral blood flow. £266,848, British Heart Foundation, 01/04/2011 – 31/03/2014.

Love, S., & Kehoe, P. Aβ metabolism: changes with age in human brain. £49,470, University

of Bristol Home UK/EU Centenary Postgraduate Research Scholarship, 01/10/2010 –

30/09/2013.

Newson, M. Coulthard, E., & Cullum, S. Base rate of symptom validity test failure in persons

with Mild Cognitive Impairment, £20,094, BRACE, 01/10/12-01/10/13.

PhD students

Cockbill, L. Control of astrocytoma (brain tumour) cancer cell motility and invasiveness by

PICK1 and other actin regulators. £87,200, MRC PhD studentship at UoB.

Isotalus , H. Neuroimaging of memory, healthy ageing and dementia. Jointly funding by MRC

and BRACE at UoB.

Ismail, S. The Psychosocial functions of Nostalgia for people affected by dementia, UWE

funded.

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Shaikh, N. Dopamine, decision making and memory consolidation, Wellcome PhD student

stipend at UoB.

Swirski, M. The contribution of Aβ in dementia with Lewy bodies. PhD studentship at UoB.

Watts, H. Discourses of care: Interactions between care home staff with residents early /

mid-stage dementia. PhD studentship at UWE.

Wood, B. Hippocampal Subfield Volumetry as a Marker of Early Alzheimer's Disease. PhD

studentship at UoB.

Publications

Peer review Publications (2012)

Brayne, C. Bayer, A., Boustani, M., Clare, L., Cullum, S., Dening, T., Flicker, L., Fox, C.,

Goodman, C., Katona, C., Lafortune, L., Manthorpe, J., Mavrodavis, A., McShane, R., Rait,

G., Richards, M., & Robinson, L. (2012). A rallying call for an evidenced based approach to

dementia and related policy development. BMJ, 27 Feb 2013. Available online at;

http://www.bmj.com/content/345/bmj.e8588/rr/633370

Peer review Publications (2013)

Allen, S.J., Watson, J.J., Shoemark, D., Barua, N.U., & Patel, N.K. (2013). GDNF, NGF and

BDNF as therapeutic options for neurodegeneration. Pharmacology & Therapeutics.

138(2), 155 - 175. doi: 10.1016/j.pharmthera.2013.01.004

Canevelli, M., Adali, N., Cantet, C., Andrieu, S., Bruno, G., Cesari, M., Vellas, B. & ICTUS/DSA

Group. (2013). Impact of behavioral subsyndromes on cognitive decline in

Alzheimer's disease: data from the ICTUS study. Journal of Neurology, 260(7):1859-

1865. doi: 10.1007/s00415-013-6893-3

Cheston, R. (2013). Assimilation of problematic voices within psychotherapeutic work with

people with dementia. Neuro-disability and Psychotherapy, 1(1), 70-95.

Clare, L., Bayer, A., Burns, A., Corbett, A., Jones, R., Knapp, M., Kopelman, M., Kudlicka, A.,

Leroi, I., Oyebode, J., Pool, J., Woods, B., & Whitaker, R. (2013). Goal-oriented

cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre

single-blind randomised controlled trial (GREAT).Trials, 14(1),152.

Coulthard, E.J., Archer, H.A., Smailagic, N., John, C., Giannakou, A., Holmes, R.B., & Cullum, S.

(2013). rCBF SPECT for detection of frontotemporal dementia in people with

suspected dementia (Protocol). The Cochrane Library, Issue 12. doi:

10.1002/14651858.CD010896

Crompton, L.A., Byrne, M.L., Taylor, H., Kerrigan, T.L., Bru-Mercier, G., Badger, J.L., Barbuti,

P.A., Jo, J., Tyler, S.J., Allen, S.J., Kunath, T., Cho, K., & Caldwell, M.A. (2013).

Stepwise, non-adherent differentiation of human pluripotent stem cells to generate

basal forebrain cholinergic neurons via hedgehog signaling. Stem Cell Research,

11(3),1206-1221. doi: 10.1016/j.scr.2013.08.002

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Damian, M., Hausner, L., Jekel, K., Richter, M., Froelich, L., Almkvist, O., Boada, M., Bullock,

R., De Deyn, P.P., Frisoni, G.B., Hampel, H., Jones, R.W., Kehoe, P., Lenoir, H.,

Minthon, L., Olde Rikkert, M.G., Rodriguez, G., Scheltens, P., Soininen, H., Spiru, L.,

Touchon, J., Tsolaki, M., Vellas, B., Verhey, F.R., Winblad, B., Wahlund, L.O., Wilcock,

G., & Visser, P.J. (2013). Single-Domain Amnestic Mild Cognitive Impairment

Identified by Cluster Analysis Predicts Alzheimer's Disease in the European

Prospective DESCRIPA Study. Dementia and Geriatric Cognitive Disorders, 36(1-2), 1-

19. doi: 10.1159/000348354

Davis, D.H.J., Creavin, S.T., Yip, J.L.Y., Noel-Storr, A.H., Brayne, C., & Cullum, S. (2013). The

Montreal Cognitive Assessment for the diagnosis of Alzheimer’s disease and other

dementia disorders. Cochrane Database of Systematic Reviews, Issue 10. Art. No.:

CD010775. doi: 10.1002/14651858.CD010775.

Davis, H.J., Creavin, S.T., Noel-Storr, A., Quinn, T.J., Smailagic, N., Hyde, C., Brayne, C.,

McShane, R., Cullum, S. & Patel, A. (2013). Neuropsychological tests for the

diagnosis of Alzheimer’s disease dementia and other dementias: a generic protocol

for cross-sectional and delayed-verification studies (Protocol). The Cochrane Library,

Issue 3. doi: 10.1002/14651858.CD010460

Elwood, P., Galante, J., Pickering, J., Palmer, S., Bayer, A., Ben-Shlomo, Y., Longley, M., &

Gallacher, J. (2013). Healthy Lifestyles Reduce the Incidence of Chronic Diseases and

Dementia: Evidence from the Caerphilly Cohort Study. PLoS One, 8: e81877.

doi:10.1371/journal.pone.0081877

Fennell, J., Nash, K. & Leonards, U. (2013). Visual distractor interference on foot movements

during walking. Perception, 42 (ECVP Abstract Suppl.), 49. Available from;

http://www.perceptionweb.com/ecvp/ecvp13.pdf

Grigore, E.C., Eder, K., Pipe, A.G., Melhuish, C., & Leonards, U. (2013). Joint action

understanding improves robot-to-human object handover. 2013 IEEE/RSJ

International Conference on Intelligent Robots and Systems (IROS); November 3-7,

2013. Tokyo, Japan; 978-1-4673-6358-7/13 ©2013 IEEE; pp. 4622-4629.

doi.10.1109/iros.2013.6697021

Hoey, S.E., Buonocore, F., Cox, C.J., Hammond, V.J., Perkinton, M.S., & Williams, R.J. (2013).

AMPA Receptor Activation Promotes Non-Amyloidogenic Amyloid Precursor Protein

Processing and Suppresses Neuronal Amyloid-β Production. PLoS One, 8(10),

e78155. doi: 10.1371/journal.pone.0078155

Hoffman, P., Jones, R.W. & Lambon Ralph, M.A. (2013). Be concrete to be comprehended:

Consistent imageability effects in semantic dementia for nouns, verbs, synonyms

and associates. Cortex, 49 (5), 1206-18. doi: 10.1016/j.cortex.2012.05.007

Holmes, R.B., Hoffman, S.M. & Kemp, P.M. (2013). Generation of realistic HMPAO SPECT

images using a subresolution sandwich phantom. Neuroimage, 1(81), 8-14. doi:

10.1016/j.neuroimage.2013.05.003

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Lafortune, L., Khan, A., Martin, S., Fox, C., Cullum, S., Dening, T., Rait, G., Katona, C., &

Brayne, C. (2013). A systematic review of costs and benefits of population screening

for dementia. The Lancet, 382(Supl. 3), S56. doi: 10.1016/S0140-6736(13)62481-2

Leonards, U., Hedge, C., Thiel, H., Taylor, R., Broyd, A., Clark, J., & Rowe, A. (2013). Joint and

visual shifts of attention are based on similar mechanisms – or are they? An

individual differences approach. Perception, 42 (Suppl.) 29.

Martinez, C., Jones, R.W. & Rietbrock, S. (2013). Trends in the prevalence of antipsychotic

drug use among patients with Alzheimer's disease and other dementias including

those treated with antidementia drugs in the community in the UK: a cohort study.

BMJ Open - Neurology; 3. doi: 10.1136/bmjopen-2012-002080

Noonan, K.A., Jefferies, E., Garrard, P., Eshan, S. & Lambon Ralph, M.A. (2013).

Demonstrating the qualitative differences between semantic aphasia and semantic

dementia: a novel exploration of nonverbal semantic processing. Behavioural

Neurology, 26(1-2), 7-20. doi: 10.3233/BEN-2012-110200

Noonan, K.A., Jefferies, E., Visser, M. & Lambon Ralph, M.A., (2013). Going beyond Inferior

Prefrontal Involvement in Semantic Control: Evidence for the Additional

Contribution of Dorsal Angular Gyrus and Posterior Middle Temporal Cortex. Journal

of cognitive neuroscience, 25(11), 1824-1850. doi: 10.1162/jocn_a_00442

Pereira Morais, M.P., Marshall, D., Flower, S.E., Caunt, C.J., James, T.D., Williams, R.J.,

Waterfield, N.R., & van den Elsen, J.M. (2013). Analysis of protein glycation using

fluorescent phenylboronate gel electrophoresis. Scientific Reports, 3:1437. doi:

10.1038/srep01437

Shaikh, N.N. & Coulthard, E.J. (2013). Memory consolidation — Mechanisms and

opportunities for enhancement. Translational Neuroscience, 4(4), 448-457

Tamuno, A., Ben-Shlomo, Y., Cooper, R., Hardy, R., Deary, I.J., Elliott, J., Harris, S.E.,

Hypponen, E., Kivimaki, M., Kumari, M., Maddock, J., Power, C., Starr, J.M., Kuh, D.,

Day, I.N.M., & the HALCyon Study Team. (2013). Genetic Variants Influencing

Biomarkers of Nutrition Are Not Associated with Cognitive Capability in Middle-Aged

Older Adults. The Journal of Nutrition,143(5), 606-612. doi: 10.3945/jn.112.171520

Teles-Grilo Ruivo, L.M. & Mellor, J.R. (2013). Cholinergic modulation of hippocampal

network function. Frontiers in Synaptic Neuroscience, 5, 2.

doi: 10.3389/fnsyn.2013.00002

Vermeiren, A.P., Bosma, H., Visser, P.J., Zeegers, M.P., Graff, C., Ewers, M., Frisoni, G.B.,

Frölich, L., Hampel, H., Jones, R.W., Kehoe, P.G., Lenoir, H., Minthon, L., Nobili,

F.M., Olde Rikkert, M., Rigaud, A.S., Scheltens, P., Soininen, H., Spiru, L., Tsolaki,

M., Wahlund, L.O., Vellas, B., Wilcock, G., Elias-Sonnenschein, L.S. & Verhey, F.R.

(2013). The Association Between APOE ε4 and Alzheimer-type Dementia Among

Memory Clinic Patients is Confined to those with a Higher Education. The

DESCRIPA Study. Journal of Alzheimer’s Disease, 35(2): 241-246. doi: 10.3233/JAD-

122182

13

Wang, H., Sessions, R.B., Prime, S.S., Shoemark, D.K., Allen, S.J., Hong, W., Narayanan, S., &

Paterson, I.C. (2013). Identification of novel small molecule TGF-β antagonists using

structure-based drug design. Journal of Computer-Aided Molecular Design, 27(4),

365-72. doi: 10.1007/s10822-013-9651-9

Wimo, A., Reed, C.C., Dodel, R., Belger, M., Jones, R.W., Happich, M., Argimon, J.M., Bruno,

G., Novick, D., Vellas, B. & Haro, J.M. (2013). The GERAS Study: A Prospective

Observational Study of Costs and Resource Use in Community Dwellers with

Alzheimer's Disease in Three European Countries - Study Design and Baseline

Findings. Journal of Alzheimer’s Disease, 36(2), 285-399. doi: 10.3233/JAD-122392

Peer review Publications (2014)

Alfred, T., Ben-Shlomo. Y., Cooper. R., Hardy. R., Cooper. C., Deary. I.J., Elliott. J., Gunnell. D.,

Harris. S.E., Kivimaki. M., Kumari. M., Martin, R.M., Power, C., Sayer, A.A., Starr, J.M.,

Kuh, D., Day, I.N.M., & the HALCyon Study Team. (2014). Associations between APOE

and low-density lipoprotein cholesterol genotypes and cognitive and physical

capability. Age, 36(4), 9673. doi: 10.1007/s11357-014-9673-9.

Bayer, A., Phillips, M., Porter, G., Leonards, U., Bompas, A., & Tales, A. (2014). Abnormal

inhibition of return in mild cognitive impairment: is it specific to the presence of

prodromal dementia? Journal of Alzheimer’s Disease, 40(1), 177-189.

doi :10.3233/JAD-131934

Bocchetta, M., Galluzzi, S., Kehoe, P.G., Aguera, E., Bernabei, R., Bullock, R., Ceccaldi, M.,

Dartigues, J.F., de Mendonça, A., Didic, M., Eriksdotter, M., Félician, O., Frölich, L.,

Gertz, H.J., Hallikainen, M., Hasselbalch, S.G., Hausner, L., Heuser, I., Jessen, F.,

Jones, R.W., Kurz, A., Lawlor, B., Lleo, A., Martinez-Lage, P., Mecocci, P., Mehrabian,

S., Monsch, A., Nobili, F., Nordberg, A., Olde Rikkert, M., Orgogozo, J.M., Pasquier,

F., Peters, O., Salmon, E., Sánchez-Castellano, C., Santana, I., Sarazin, M., Traykov, L.,

Tsolaki, M., Visser, P.J., Wallin, A.K., Wilcock, G., Wilkinson, D., Wolf, H., Yener, G.,

Zekry, D., Frisoni, G.B. (2014)

The use of biomarkers for the etiologic diagnosis of MCI in Europe: An EADC survey.

Alzheimer’s & Dementia. Aug 20 [Epub ahead of print]. doi:

10.1016/j.jalz.2014.06.006

Canevelli, M., Adali, N., Kelaiditi, E., Cantet, C., Ousset, P-J., Cesari, M. & ICTUS/DSA Group

(2014). Effects of Gingko biloba supplementation in Alzheimer's disease patients

receiving cholinesterase inhibitors: Data from the ICTUS study. Phytomedicine, 21(6),

888 - 892. doi: 10.1016/j.phymed.2014.01.003. Note: Jones, R.W. member of the

ICTUS group.

Clarke, N., & Jones, R.W. (2014). 25 years and counting. The Journal of Dementia Care, 22(3),

14-15.

Dodd, E., Cheston, R., Fear, T., Brown, E., Fox, C., Morley, C., Jefferies, R. & Gray, R. (2014). An

evaluation of Primary Care Led Dementia Diagnostic Services in Bristol, BMC Health

Services Research, 14, 592. doi:10.1186/s12913-014-0592-3

14

Eder, K.I., Harper, C., & Leonards, U. (2014). Towards the safety of human-in-the-loop

robotics: Challenges and opportunities for safety assurance of robotic co-workers.

23rd IEEE International Symposium on Robot and Human Interactive

Communication, pp. 660-665; Institute of Electrical and Electronics Engineering, Inc.

(IEEE). doi: 10.1109/roman.2014.6926328

El Hindy, M., Hezwani, M., Corry, D., Hull, J., El Amraoui, F., Harris, M., Lee, C., Forshaw, T.,

Wilson, A., Mansbridge, A., Hassler, M., Patel, V.B., Kehoe, P.G., Love, S., & Conway,

M.E. (2014). The branched-chain aminotransferase proteins: novel redox

chaperones for protein disulfide isomerase-implications in Alzheimer's disease.

Antioxid Redox Signal, 20(16), 2497-513. doi: 10.1089/ars.2012.4869

Gaysina, D., Gardner, M.P., Richards, M., & Ben-Shlomo, Y. (2014). Cortisol and cognitive

function in midlife: the role of childhood cognition and educational attainment.

Psychoneuroendocrinology, 47, 189-198. doi: 10.1016/j.psyneuen.2014.05.018

Green, C.J., Holly, J.M.P., Bayer, A., Fish, M., Ebrahim, S., Gallacher, J., & Ben-Shlomo Y.

(2014). The role of IGF-I, IGF-II and IGFBP-3 in male cognitive ageing and dementia

risk: the Caerphilly Prospective Study. Journal of Alzheimer’s Disease, 41, 867–875.

doi: 10.3233/JAD-132183

Haro, J.M., Kahle-Wrobleski, K., Bruno, G., Belger, M., Dell'Agnello, G., Dodel, R., Jones, R.W.,

Reed, C.C., Vellas, B., Wimo, A. & Argimon, J.M. (2014). Analysis of burden in

caregivers of people with Alzheimer's disease using self-report and supervision

hours. The Journal of Nutrition, Health & Aging; 18(7), 677-84. doi: 10.1007/s12603-

014-0036-0

Hu, M.T.M., Szewczyk-Krolikowski, K., Tomlinson, P., Nithi, K., Rolinski, M., Murray, C.,

Talbot, K., Ebmeier, K.P., Mackay, C.E., & Ben-Shlomo, Y. (2014). Predictors of

Cognitive Impairment in an Early Stage Parkinson’s Disease Cohort. Movement

Disorders, 29(3), 351-359. doi: 10.1002/mds.25748

Jones, R.W., Romeo, R., Trigg, R., Knapp, M., Sato, A., King, D., Niecko, T., & Lacey, L. (DADE

Investigator Group). (2014). Dependence in Alzheimer's disease and service use

costs, quality of life, and caregiver burden: The DADE study. Alzheimer’s &

Dementia, [E-pub ahead of print] . doi: 10.1016/j.jalz.2014.03.001

Kokkonen, T-M., Cheston, R., Dallos, R., & Smart, C. (2014). Attachment and coping of

dementia care staff: The role of staff attachment style, geriatric nursing self-efficacy,

and approaches to dementia in burnout, Dementia: the International Journal of

Social Research and Policy, 13(4), 544–568. doi: 10.1177/1471301213479469

Leonards, U., Fennell, J.G., Trivasse, H.E., & Redmill, D.W. (2014). Nudge, nudge, nudge –

How floor patterns impact on walking trajectories. Perception, 43(Suppl.), 173.

Lishman, E., Cheston, R.. & Smithson, J. (2014). The Paradox of Dementia: meaning making

before and after receiving a diagnosis of dementia, Dementia: the International

Journal of Social Research and Policy, published on line 27/2/14. doi:

10.1177/1471301214520781

15

Marshall, A., Spreadbury, J., Cheston, R., Coleman, P., Ballinger, C., Mullee, M., Pritchard, J.,

Russell, C., & Bartlett, E. (2014). A Pilot Randomised Control trial to compare

changes in quality of life for participants with early diagnosis dementia who attend a

"Living Well with Dementia" group compared to waiting list control. Aging and

Mental Health, published on line 8/9/14. doi: 10.1080/13607863.2014.954527

Reed, C., Belger, M., Dell'Agnello, G., Wimo, A., Argimon, J.M. Bruno, G., Dodel, R., Haro,

J.M., Jones, R.W. & Vellas, B. (2014). Caregiver Burden in Alzheimer's Disease:

Differential Associations in Adult-Child and Spousal Caregivers in the GERAS

Observational Study. Dementia and Geriatric Cognitive Disorders Extra, (4): 51-64.

doi: 10.1159/000358234

Ritchie, C.W., Bajwa, J., Coleman, G., Hope, K., Jones, R.W., Lawton, M., Marven, M. &

Passmore, P. (2014). Souvenaid: a new approach to management of early

Alzheimer's disease. The Journal of Nutrition, Health & Aging, 18(3), 291-9. doi:

10.1007/s12603-013-0411-2

Stothart, G., Tales, A., & Kazanina, N. (2014). Double peaked P1 visual evoked potentials in

healthy ageing. Clinical Neurophysiology, 125(7), 1471–1478. doi:

10.1016/j.clinph.2013.11.029

Tan, M.G., Lee, C., Lee, J.H., Francis, P.T., Williams, R.J., Ramírez, M.J., Chen, C.P., Wong, P.T.,

& Lai, M.K. (2014). Decreased rabphilin 3A immunoreactivity in Alzheimer's disease

is associated with Aβ burden. Neurochemistry International, 64, 29-36. doi:

10.1016/j.neuint.2013.10.013.

Trigg, R., Jones, R.W., Knapp, M., King, D., & Lacey, L.A, (DADE-2 Investigator Groups).

(2014). The relationship between changes in quality of life outcomes and

progression of Alzheimer's disease: results from the Dependence in AD in England 2

longitudinal study. International Journal of Geriatric Psychiatry, published on line

12/6/14. doi: 10.1002/gps.4150

Wimo, A., Ballard, C., Brayne, C., Gauthier, S., Handels, R., Jones, R.W., Jonsson, L.,

Khachaturian, A.S. & Kramberger, M. (2014). Health economic evaluation of

treatments for Alzheimer's disease: impact of new diagnostic criteria. Journal of

Internal Medicine, 275(3), 304-16. doi: 10.1111/joim.12167

Books

Christopher, G. (2014). The Psychology of Ageing: From Mind to Society. London: Palgrave

Macmillan.

Book chapters

Cullum, S. (2013). Clinical aspects of dementia: the management of dementia. In Dening, T.

& Thomas, A. (Eds.). The Oxford Textbook of Old Age Psychiatry (5th Edition).

Oxford: Oxford University Press.

Jones, R.W. Pharmacological treatment of dementia. In: Dening,T. & Thomas, A. eds.

Textbook of Old Age Psychiatry, 2nd Edition. Oxford: Oxford University Press. 2013:

Chapter 38, 503-512.

16

Jones, R.W. Services for people with mild dementia. In: H. de Waal, C. Lyketsos, D. Ames & J.

O'Brien, eds. Designing and Delivering Dementia Services. Wiley-Blackwell 2013;

Section 2.5 Service models p 60-72.

In press

Conway, M.E. & Hutson, S.M. - The role of the human branched chain aminotransferase

proteins in BCAA metabolism. Branched chain aminotransferase in health and

disease. In. Preedy, V & Patel, V.B. (Eds.). Publisher, Springer.

Dodd, E., Cheston, R., Ismail, S., Cullum, S., Gatting, L., Jefferies, R., Fear, T., & Gray, R. -

Primary Care Led Dementia Services: themes from families, patients and health

professionals, Dementia: the International Journal of Social Research and Policy.

Noel-Storr, A.H., McCleery, J.M., Richard, E., Ritchie, C.W., Flicker, L., Cullumm S.J., Davis, D.,

Quinn, T.J., Hyde, C., Rutjes, A.W.S., Smailagic, N., Marcus, S., Black, S., Blennow, K.,

Brayne, C., Fiorivanti, M., Johnson, J.K., Köpke, S., Schneider, L.S., Simmons, A.,

Mattsson, M., Zetterberg, H., Bossuyt, P.M.M., Wilcock, G. & McShane, R. -

Reporting standards for studies of diagnostic test accuracy in dementia: the

STARDdem initiative. Neurology.

Stothart, G., Näätänen, R., Haworth, J., Kazanina, N., & Tales, A. - Early visual evoked

potentials in Alzheimer’s disease and mild cognitive impairment. Journal of

Alzheimer’s Disease.

Snow, K., Cheston, R. & Smart, C. - . ‘Making sense’ of dementia: Exploring the use of the

MAPED to understand how couples process a dementia diagnosis, Dementia: the

International Journal of Social Research and Policy.

Under review

Fennell, J.G., Goodwin, C., Burn, J.F., & Leonards, U. (2014).Vision versus body – competitive

mechanisms between visual perceptual grouping and biomechanics in walking.

Evans, N., Cheston, R., & Harris, N. (2014), Personal message cards: an evaluation of an

alternative method of delivering Simulated Presence therapy. Dementia: the

International Journal of Social Research and Policy.

Hull, J., Patel, V.B., Hutson, S.M. & Conway, M.E. (2014). New insights into the role of the

branched chain aminotransferase proteins in the human brain. Journal of

Neuroscience Research.

Hull, J., El Hindy, M.E., Kehoe, P.G., Chalmers, K., Love, S., and Conway, M.E. (2014).

Overexpression of the branched chain aminotransferase proteins in the human brain

in the brains of patients with Alzheimer’s disease. Journal of Alzheimer’s disease.

Knight, M.J., Wood, B., Coulthard, E., & Kauppinen, R.A. (2014). Spin echo relaxation

anisotropy in the human brain in vivo: A quantitative parameter with broad

applications in neuroimaging. (PNAS submitted 10/2014)

Leonards, U., Fennell, J.G., Oliva, G., Drake, A., & Redmill, D.W. (2014). Treacherous

pavements: paving slab patterns modify intended walking directions.

17

Shoemark, D.K. & Allen, S.J. (2014). The microbiome and disease - reviewing the links

between the oral microbiome, ageing and sporadic Alzheimer’s disease. Journal of

Alzheimer’s Disease.

Shoemark, D.K., Williams, C. Fahey, M.S., Watson, J.J., Tyler, S.J., Scoltock, S.J., Ellis, R.Z.,

Elaine Wickenden, E., Burton, A., Hemmings, J.L., Bailey, C.D., Dawbarn, D., Jane,

D.E., Willis, C.L., Sessions, R.B., Allen, S.J.* & Crump, M.P.* - Design and NMR

structure determination of a TrkAIg2 domain construct for use in drug discovery.

Journal of Medicinal Chemistry. *joint corresponding authors

Wood, B., Knight, M.J., Tsivos, D., Oliver, R., Coulthard, E. & Kauppinen, R.A. - Magnetic

resonance scanning and segmentation procedure at 3T for hippocampal subfield

volumetry. Brain & Behaviour.

Conference presentations

Oral

Bagshaw, P. (2014). Dementia: a Primary Care perspective, BRACE conference, 4th

November.

Bagshaw, P. Dementia the South Gloucestershire experience.

Christopher, G. (2014). A fear of dementia: how people respond to diagnosis. CHCR Health

Research for Impact Conference, November, University of the West of England,

Bristol.

Creavin, S. (2014). Crowdsourcing citation screening for a Cochrane diagnostic test accuracy

review on the mini-mental state examination. National GP ACF conference, Oxford.

Creavin, S. (2014). Diagnostic utility of clinical features for diagnosis dementia: the Caerphilly

Prospective Study. Prize Abstract, National GP ACF conference, Oxford.

Cheston, R. (2014). Psychotherapy and Dementia – all day workshop to North-West Faculty

of Psychology in Preston, 30th January.

Cheston, R. & Watts, S. (2014). Post-diagnostic support and psychological interventions,

Faculty of Psychology of Older People and Dementia Action Alliance Joint meeting,

London, 25th March.

Cheston, R. (2014). The Psychology of Dementia: the shadow of dementia, all day workshop

to Bath University Clinical Psychology Training Course, Bath, 25th March.

Cheston, R. et al. (2014). The Living Well with Dementia group project, Faculty of Psychology

of Older People Annual Conference, Shrewsbury, 26th June.

Cheston, R. (2014). Psychological therapy: trial of a new intervention, Dementia Action

Alliance Annual meeting, London, 16th September.

Cheston, R. (2014). Living well with dementia therapy groups, 9th UK Dementia Congress,

Brighton 12th November.

18

Cheston, R. (2014). Living well with dementia therapy groups, AWP Mental Health Trust

Annual R&D conference, Chippenham, 13th November.

Conway, M. (2014). Invited speaker at the 11th International Conference on Brain Energy

Metabolism, University of Maryland Baltimore, USA, 11th – 14th May.

Crompton, L. (2012). Society for Neuroscience conference in New Orleans, USA.

Cullum, S. (2013). Dementia: does everyone want an early diagnosis? Public debate TEDMED

Live, April, Bristol. Available at;

http://www.bristolhealthpartners.nhs.uk/media/1710013/tedmed_programme.pdf

Cullum, S. & Ewins, L. (2014) Crowdsourcing citation screening for a Cochrane diagnostic test

accuracy review on the MMSE. Cochrane Dementia and Cognitive Improvement

Group (CDCIG), Oxford, September.

Foster, L. (2014). Developing Family Work in dementia. UK Dementia Congress, November.

Hedge, C., Stothart, G., Todd-Jones, J., Rojas Frias, P., Magee, K., Leonards, U., Kazanina, N.,

Minton, E., Andohi, J., Thai, N.J., Brooks, J. (2013). The neural generators of visual

mismatch: a shared frontal generator across modalities. Annual meeting of the

Cognitive Neuroscience Society, San Francisco, USA.

Knight, M.J., Wood, B., Coulthard, E., Wang, D., Ugurbil, K., & Kauppinen, R.A. (2014).

Quantitative T2 MRI by a multi-band spin-echo sequence for assessment of

imminent dementia. BC ISMRM Annual Conference, Edinburgh 3rd – 5th September,

2014.

Lafortune, L., Martin, S., Cullum, S., Dening, T., Rait, G., Fox, C,. Katona, C. & Brayne, C.

(2014). There is no evidence supporting population screening for dementia:

reporting on two systematic reviews looking at attitudes, preferences and available

tools. Alzheimer's Association International Conference, July, Boston, Mass, USA.

Leonards, U., Fennell, J., Goodwin, C., & Burn, J. (2014). Biased competition between vision

and biomechanics in human walking. Asian Pacific Conference on Vision, Japan.

R.I.C.E. (2014). Carers’ satisfaction with inpatient hospital care: Findings of dementia

carers’ survey.

R.I.C.E. (2014). Cost and resource use in non-institutionalised Alzheimer’s patients - results

from an observational study in the UK over 18 months.

R.I.C.E (2014). The future of Alzheimer’s disease assessment and diagnosis: Challenges?

Solutions? Symposium presented at the Alzheimer’s Association International

Conference, Copenhagen, 15th July. Professor Jones chaired the symposium and was

also a speaker.

R.I.C.E. (2014). A talk on Dementia at the B&NES NHS Health Check ‘Best Practice Event’, 5th

February. Dr J Mann presented.

Ruud ter Meulen (Invited Speaker) (2014). Dementia: an ethical framework. Conference

Person and Dementia, Dusseldorf, Germany 10th – 11th July.

19

Ruud ter Meulen (Invited Speaker) (2014). Dementia: an ethical framework. Solidarity and

care for people with dementia Annual Conference of the European Association of

Centers for Medical Ethics EACME, Lille 2nd – 4th October.

Stothart, G. (2014). Early visual evoked potentials and mismatch negativity in Alzheimer’s

disease and Mild Cognitive Impairment; cross-sectional findings and longitudinal

follow-up. International Organisation of Psychophysiology Congress, Hiroshima

Japan.

Patel, A. (2013). Members of the group have presented a Poster at the Royal College of

Psychiatrists International Congress in Edinburgh on Crowdsourcing citation

screening for a Cochrane diagnostic test accuracy review on the mini-mental state

examination. Available at; http://www.youtube.com/watch?v=ufwQZKuYkuE

Williams, R.J. (2014). Dietary Flavonoids as Regulators of APP processing: A Risk Reduction

Strategy for AD. FENS ILSI Workshop: Nutrition for the Ageing Brain: Towards

Evidence for an Optimal Diet, Milan, July.

Wood, B., Knight, M.J., Coulthard, E., & Kauppinen, R.A. (2014). Hippocampal subfield and

Entorhinal cortex vulnerability in Alzheimer ’s disease and preclinical dementia using

clinically appropriate MR acquisition: A preliminary study. BC ISMRM Annual

Conference, Edinburgh 3rd – 5th September.

Poster

Allen, S. (2013). Human proBDNF Val66Met polymorphism: binding and signalling profiles.

5th Conference on Advances in Molecular Mechanisms Underlying Neurological

Disorders. 23rd – 26th June, University of Bath, UK.

Allen, S. (2013). The human proBDNF variant Met66: A physico-biochemical study.

Alzheimer’s Research UK Conference 2013. 11th-12th March, Belfast, Ireland, UK.

Allen, S. (2013). Barbican centre, London, UK. Binding characteristics and downstream

signalling of the common proBDNF Val66Met polymorphism. British Neuroscience

Association 2013: Festival of Neuroscience. 7th -10th April.

Bufton, H. (2014). Promoting the role of occupational therapy in supporting carers of those

with dementia. Poster for ‘Carers Week’ on June 10th, 2014.

Cox, C.J., Choudhry, F., Peacey, E, Perkinton, M.S., Richardson, J.C., Howlett, D.R.,

Lichtenthaler, S.R., Francis, P.T., & Williams, R.J. (2014). Dieatary flavonoid

epicatechin reduces amyloid beta pathology in TASTPM mutant mice. Alzheimer’s

Research UK Conference, Oxford.

Crompton, L. Alzheimer’s Research UK annual conference in Oxford, 2014.

Crompton, L. (2013). Anne Rowling clinic, Edinburgh.

20

Cullum, S., Creavin, S., Ewins, L., Rayment, D. & Noel-Storr, A. (2013). Crowdsourcing citation

screening for a Cochrane diagnostic test accuracy review on the mini-mental state

examination. International Congress of the Royal College of Psychiatrists, Edinburgh.

Hancock, J., Coulthard, E. & the Bristol Health Partners Dementia HIT. (2014). The Bristol

Health Partners Dementia HIT: Baseline attitudes toward dementia in the area. From

research to practice, 28th January, Southampton

Hancock, J., Coulthard, E. & the Bristol Health Partners Dementia HIT. (2014). The Bristol

Health Partners Dementia HIT: Baseline attitudes toward dementia in the area.

Alzheimer’s Research UK, 25th March, Oxford.

Holmes, R. (2014). PET Imaging Standardisation Using Novel 3D-Printed Brain Phantoms.

Alzheimer’s Imaging Consortium, 12th July, Copenhagen.

Law, B., Cox, C.J., & Williams, R.J. (2013). Use of an APP-GAL4 Gene Reporter Assay to

Investigate the Effects of Familial APP Mutations on Neuronal Function. Society for

Neuroscience, San Diego, USA.

Lennox-Smith, A., Reed, C., Lebrec, J., Belger, M., & Jones, R.W. (2014). British Geriatrics

Society Autumn Meeting, Brighton, October.

Newson, M.A., & Sharma, A. (2013). HVLT-R: The utility of new score calculations. BPS

Division of Neuropsychology Annual Conference, London, UK, November.

Sewter, E., Jones, R.W., Hart, I., & Dyer, C. (2014). British Geriatric Society Autumn meeting,

Brighton, October.

Supervision of students

Allen, S. PhD student: Sumangali Kalinaithan 2011-2014 ProBDNF and its receptors in

Alzheimer’s Disease. University of Bristol Overseas student.

Allen, S. PhD student: Stephanie Wallis until April 2016 (September 2014 took over as

supervisor) Investigating the role of tau in neurodegenerative disease using iPSC

modelling. James Tudor funded.

Allen, S. PhD student: Rachel Wallis November 2014 - October 2017. Angioneurins and

dementia University of Bristol funded.

Allen S, MSc Molecular Neurobiology Project student in lab June- September 2013. The role

of proBDNF in tau pathogenesis

Allen, S. MSc Stem Cell – Stem cells as treatment for Alzheimer's Disease - library projects

Bufton, H. (2013/14) Informal supervision of UWE Mental Health Nursing students and

medical students.

Bufton, H. (2014/15) Possible supervision of BSc in Occupational Therapy Student and

continued informal supervision for Mental Health Nursing and Medical Students.

Conway M (2014) Jonathon Hull. (DOS) (2014). Title: The investigation of the hBCAT

proteins in control and disease human brains: Implications for glutamate toxicity.

UWE, UK.

21

Conway M (2014) Maya El Hindy. (DOS) (2014).Title: The role of phosphorylation and redox

regulation of the brain specific hBCAT proteins in vitro and in neuronal cells. UWE,

UK.

Conway M (2014) Matthew Harris. (DOS) (2012-2015).Title: Understanding the role of

dysregulated autophagy in Alzheimer’s disease. UWE, UK.

Conway M (2014) Christopher Lee. (DOS) (2012-2015) Title: The brain specific hBCAT

proteins and redox partners as biomarkers of Alzheimer’s disease and other

neurodegenerative conditions. UWE, UK.

Conway M (2014)Thomas Forshaw. (DOS) (2012-2015) Title: The role of increased hBCATm

in the endothelial cells of patients with Alzheimer’s disease. UWE, UK.

Crompton, L. PhD student who is using human induced stem cell technology to investigate

the role of Tau in Alzheimer’s and Frontotemporal Dementia.

Cullum, S. PhD supervisor – Sam Creavin. Dementia diagnosis in primary care (University of

Bristol).

Holmes, R. MSc Experimental Psychology student Kelly Warr. Effects of education on resting

state fMRI.

Holmes, R. PhD supervisor – Angus Prosser – University of Southampton. Translating imaging

biomarkers into dementia clinical practice –– co-supervision with Chris Kipps.

Holmes, R. Proposal submitted to Alzheimer’s Society doctoral training centre programme:

Biomarker Development and Application to Clinical Diagnosis in Dementia. This adds

neurochemistry and multivariate analysis to existing (mainly fellowship) work.

Leonards, U. 2nd PhD supervisor for George Stothart (degree awarded in July 2013): “The

McGurk effect in healthy and pathological ageing)

Leonards, U. 2 MSc projects together with Robin Holmes (see his info), using the ADNI2

database

Leonards, U. Several MSc (2013: Terry Mills, Theo Tillney; 2014: Karine Adamson) and 3rd

year BSc projects (2013-14: Anne Milner, Gaby Oliva, Katie Stringer, Olga Perski) on

the impact of vision on locomotion for healthy young and older participants – all

linked to the BRACE charity funded pilot study.

Noonan, K. 2013 – Eleanor Triggs – “Assessing Cognitive, Functional and Behavioural Abilities

in Patients with Mild to Moderate Dementia before and after a Four Week Course of

Cognitive Stimulation Therapy”. Awards 1st – Plymouth University BSc Psychology

Dissertation.

Noonan, K. 2014 – Clare Burgon – “The effects of cognitive stimulation therapy on

neuropsychiatric symptoms in people with dementia”. In progress – University of

Bath BSc Psychology Dissertation.

Pennington, C. MSc student who has been recruiting patients with behavioural variant

frontotemporal dementia as part of an extension to the Hippocampal Imaging in

Alzheimer's disease study

Pennington, C. BBSRC undergraduate student placement looking at correlations between

personality type and cognition in the healthy elderly

22

Sharma, K. Supervising a psychology MSc student and Dementia BSc course lecturer.

Ben-Shlomo, Y. & Whone, A. supervising Henderson, E. A randomised control trial of rivastigmine versus placebo for improving gait stability in patients with Parkinson’s disease with a past history of a fall. PDUK clinical PhD studentship

Williams, R. & Cox, C. (Alzheimer’s Society) Flavonoids as modulators of APP processing.

2010-2014

Williams, R. Victoria Hammond (BBSRC) Nicotinic receptors in Alzheimer’s Disease. 2010-

2014

Dementia-related teaching

Allen, S. (2013/14) Lecture and direct unit on neurodegeneration MSc in Molecular

Neurobiology (2013 & 2014)

Allen, S. (2013/14) Lecture in MSc in stem cell (2013 & 2014)

Allen, S. (2013/14) Lecture in Regenerative medicine module in BSc final year Cellular and

Molecular Medicine (2014)

Bufton, H. (2013/14). Dementia Carer’s Education Course- 6 week programme (the Complex

Interventions and Therapies Team staff collaborate to give these presentations).

NOTE: this will continue in 2014/15.

Bufton, H. (2013/14). Dementia Care Home Training Pilot- three times 2 hourly sessions

covering ‘Person Centred Care’, ‘Behaviour’ and ‘Non –Pharmacological Approaches

to Care’.

Bufton, H. (2013/14). Assistive technology for People with Dementia- 1 – 2 hour

presentation and question and answer session. This was presented to a post

diagnostic group by the OT for South Gloucestershire run by the South

Gloucestershire Memory Service. This presentation was delivered to ‘Milestones

Outreach Dementia Service’ staff in 2014.

Bufton, H. (2014). Question and answer session with South Gloucestershire Consultant in

Old Age Psychiatrist, Specialist Doctor in Old Age Psychiatry and Occupational

Therapist from the ‘Milestones Outreach Dementia Service’ team.

Creavin, S. (2014). TIMeLI: Towards Improving the Diagnosis of Memory Loss in General

Practice, Invited prize workshop, Vasco de Gama, WONCA, Lisbon.

Cullum, S. (2013). Cochrane workshops – diagnostic test accuracy in dementia.

Cullum, S. (2013). Dementia teaching for medical students.

Cullum, S. (2013). MRCPsych teaching on dementia.

Cullum, S. (2013). Carer education groups for dementia.

Cullum, S. (2013). Medical peer group meetings on dementia.

Cullum, S. (2013). Dementia teaching for medical students at memory clinics

Individual / group and CCG organised teaching for GPs.

23

Cullum, S. (2013). Dementia and distressing behaviours teaching for care home staff

(organised by CCG) 3 half day sessions.

Cullum, S. (2013). Dementia teaching to F1/ F2/GP trainees and Consultant mandatory

updates(NBT).

Cullum, S. (2013). Dementia teaching to general adult psychiatrists.

Cullum, S. (2013). Dementia roadshows in South Gloucestershire (general public education).

Hancock, J. (2014) Dementia. Presentation at the SPHERE dress/sense competition,

November.

Holmes, R. (2014). Imaging and analysis workshops – bridging gap between research and

clinical application. Currently in discussion with fellowship mentors – likely to be

organised via the EBI (UoB).

Howcroft, D. (2014) organised DeNDRoN rater training workshop May 2014.

Leonards, U. Neuropsychiatry (PSYC31053 – 3rd year Single Honours Psychology BSc

students) (2x1-hour lectures dedicated to neurodegenerative diseases, in particular

Dementia and Parkinson’s disease)

Leonards, U. STEMNET ambassador activity: Dementia lecture to Prior Park Medical Society

(Prior Park College); 26th November.

Mawson, G. (2013). Eight presentations at Dementia Roadshows. Five further talks at BAWA

event, Patchway Alliance launch Coniston community centre, Courtside surgery

dementia event, Stakeholder event AWP at Patchway community centre, and

Festival event at Patchway library.

R.I.C.E. runs a 4-week Carers’ Course two to three times a year, including speakers from

R.I.C.E., Stone King Solicitors, the Peggy Dodd Centre, Citizen’s Advice Bureau, The

Alzheimer’s Society, BANES Carers’ Centre and Designability (previously the Bath

Institute of Medical Engineering).

R.I.C.E. ran an afternoon session of Dementia Awareness Training for the BANES GP Clusters

on Thursday 20th March 2014.

Shoemark, D. (2013/14). MSc Unit 5 2 lectures and workshop.

Wensley, S. (2014). Student undergraduate teaching Year 4 medical students, Bristol -

dementia and delirium case studies

Yates, M. (2013/14). The Care Home Liaison Team, provides on-going training to older adult

care homes throughout Bristol. Particular focus is placed on dementia and focuses

on: understanding and managing dementia, person centred care, and meaningful

activity.

Attendance at training events

24

Doran, L. May 2014 DeNDRoN National Rater Training event for psychometric tests and

subsequent local follow up teleconferences. Training of staff across region to

undertake assessments for Brains for Dementia Research project.

Conference attendances for networking (not presenting)

Hancock, J. (2014). Yeovil District Hospital R&D department: The Patient Centred Approach,

21st March, Yeovil.

Hancock, J. (2014). People & Research West of England: Patient & Public Involvement in

Research — best evidence and future directions, 1st April, Bristol.

Hancock, J. (2014). Govtoday: The Dementia challenge, 8th April, London.

Dementia-related teaching, workshops or training events ran in 2013/2014

Conway, M. Research stand – contribution to workshop event. BRACE event, “Dementia

Hope for the Future” (Nov 2014).

Conway, M. CPD Event, “Assessment and screening for dementia” (July, 2014). This was a

collaborative CPD event with Health and Social care, UWE, keynote lectures to

clinical practioners.

Conway, M. Medical Society (February, 2014): Invited Speaker, “Trials and Tribulations of

Alzheimer’s disease research. UWE, Bristol, UK.

Conway, M. Speakers Event (January, 2014): Hosted and directed a Speakers event for

BRACE. “G8 summit sets 'ambitious' 2025 target for dementia cure.” UWE, Bristol,

UK.

Conway, M. Dementia Awareness Week (December, 2013): Dementia Awareness Week,

UWE: Invited speaker: “Why are new diagnostics important to patients with early-

onset dementia.” UWE, Bristol, UK.

Conway, M. BRACE Event (October, 2013): Organized and contributed as a panelist for

BRACE event: “Questions and Answers on Alzheimer’s disease,” hosted by Jonathon

Dimbleby. (260 people, available on podcast and streamed to twitter). UWE,

Bristol, UK.

Conway, M. ARUK Network Event (September, 2013). Presented lecture and organized

speakers for event: “Alzheimer’s disease, from bench to bedside.” The BAWA,

Bristol, UK.

Conway, M. Medical Society (February, 2013). Alzheimer’s disease: The role of BCAT

proteins.

25

Appendix A: Research activity

Projects relating to care and treatment/service delivery

BRACE Detecting the earliest hippocampal changes in Alzheimer’s disease. Elizabeth

Coulthard (co-PI), Risto Kauppinen (co-PI), Marcus Bradely, Margaret Newson. £154, 388,

01/05/2013 – 30/04/2016

BRACE Base rate of symptom validity test failure in persons with Mild Cognitive

Impairment. Margaret Newson (PI), Elizabeth Coulthard and Sarah Cullum. £20, 094,

01/10/12 – 01/10/13

Engineering and Physical Sciences Research Council (EPSRC) Digital Economy – Research

in the Wild inTouch: A video link system to improve social inclusion for people with

dementia. £180,000. Roy Jones

NIHR Health Policy Research Programme, The CHOICE study £551,408 (PR-IP-09-10-

0250065). CARE HOME FINAL STUDY: IN DEPTH EXAMINATION OF CARE (Richard Gray)

NIHR. A preliminary comparison of wards for people with dementia using patient

engagement time with other wards delivering standard care alone £249,843 (Richard

Gray)

NIHR. A Pilot Randomised Controlled trial to compare changes in quality of life for

participants with early diagnosis dementia who attend a "Living well with dementia"

group compared to waiting-list control £249,000. Marshall A, Coleman P, Cheston R (PI)

NIHR HTA. Goal Oriented Cognitive Rehabilitation In Early-Stage Alzheimer’s Disease :

Multi-Centre Single-Blind Randomised Control Trial (GREAT). £2,430,568, Roy Jones

BRACE pilot grant, Identifying the causes for increased falls in dementia – a pilot study in

healthy older and younger volunteers; £53,255. Ute Leonards with Judy Haworth

BRACE equipment grant. Gait changes in people with AD and the effect of galantamine

(£9,000) Ute Leonards with Judy Haworth

Projects relating to cause and cure

Alzheimer’s Society. Disentangling the genetic, pathophysiological and classification

complexities of vascular dementia. Kehoe PG (PI), Passmore P, Love S, Ben-Shlomo Y,

Munafo M.

Alzheimer’s Society/British Heart Foundation. A randomized controlled trial of calcium

channel blockade (CCB) with amlodipine for the treatment of subcortical ischaemic

vascular dementia (SIVD). Passmore P, O’Sullivan M, Kehoe P, Holmes C, Bath P, Stewart

R, Ballard C, Jones R, Coulthard C, Corbett A, Thomas A, Wallach S, Connolly P, Canning R.

01/06/2013 - 31/01/2017 ~ £2,763,650 (final award amount under negotiation)

Alzheimer's Research UK. “A multi-centre study using a validated high resolution

metabolomics methodology to investigate Alzheimer's disease (AD)”, Green B, Passmore

P, Graham S, McGuiness B, Kehoe P (Co-PI), Holscher C. 01/11/2012 - 31/04/2013 :

£100,000

Alzheimer's Research UK Collaborative grant. Contribution of Abeta to Lewy Body

Diseases. Miners JS, Kehoe PG (Co-PI), Love S. 01/04/2012 - 30/03/2013 : £39,771

Alzheimer’s Research UK. Evaluating the relationship between ischaemia and

neurodegeneration in post-mortem brain tissue. Love S, Kehoe PG (Co-PI). 01/10/2011 -

30/09/2015, £263,640

26

Alzheimer's Research UK ARUK-PG2012-8 "Investigation into the impact of systemic

inflammation due to infection on microglial phenotype and its contribution to

Alzheimer’s disease neuropathology" Boche D, Holmes C, Love S, Nicoll J, Perry H.

01/01/2013-31/12/2016, £316,261.24

Alzheimer's Research UK NCG2012A-2 "Contribution of Aβ to Parkinson's disease

dementia" Miners S, Love S, Kehoe P, Revesz T, Holton J. 04/04/2012-03/04/2013,

£39,922

Alzheimer's Research UK ART-PG2011-1 "Evaluating the relationship between ischaemia

and neurodegeneration in post-mortem brain tissue" Love S, Kehoe PG 03/10/2011-

02/10/2015, £290,743

Alzheimer's Research UK ARUK-NCG2013A-3. "Assessment of neuropathological changes

associated with vascular dementia: validation of a consensus approach" Love S, Ansorge

O, Attems J, Costelloe C, Hortobagyi T, Ironside J, Kalaria R, Kehoe P, King A, Mann D,

Neal J, Skrobot O. 01/03/2013-28/02/2015, £93,151

Alzheimer’s Research UK Hippocampal subregions in early Alzheimer's disease E

Coulthard (PI), Risto Kaupinnen, Margaret Newson, Marcus Bradley £49,999 01/05/2013-

01/05/2015.

Alzheimer's Brain Bank UK (jointly funded by Alzheimer's Research UK and the

Alzheimer's Society). Brains for Dementia Research 5-year renewal (Bristol component).

Kehoe P, Love S, Coulthard E, Miners S. 01/04/2013-31/03/2018, £497,897

BRACE. A new approach to enhance memory consolidation in dementia Elizabeth

Coulthard (PI), Jack Mellor, Netasha Shaikh 01/05/2013-30/04/2015 £50,000

BRACE. The Role of dopamine in memory consolidation Elizabeth Coulthard (PI),

Margaret Newson, Demitra Tsivos, Alan Whone £21,440. Start date 7th November 2011

BRACE. Use of IPS technology to model Alzheimer's disease in vitro: assessing the

influence of disease status and APOE genotype on basal forebrain-type neurons derived

from skin fibroblasts. Caldwell M, Love S, Coulthard E, Uney J, Kehoe PG (Co-PI).

01/03/2012 – 28/02/2014 : £164,409

BRACE. Base rate of symptom validity test failure in persons with mild cognitive

impairment. Margaret Newson (PI), Elizabeth Coulthard and Sarah Cullum (2012). £20,

094

British Heart Foundation. Influence of amyloid β peptide (Aβ) on ECE-mediated regulation

of cerebral blood flow. Love S, Kehoe PG (Co-PI), Paton J. 01/04/2011 - 31/03/2014 :

£266,848

Institute of Physics and Engineering in Medicine Innovation and Research Award £5,600 –

Improvements in PET/SPECT Anthropomorphic Phantoms Using 3D Printing. Robin

Holmes

Medical Research Council PhD scholarship. Angiotensin II in the brain: the link between

dementia and hypertension. Kehoe PG (Co-PI), Paton JFR.01/10/2011 - 30/09/2015:

£87,200

MRC PhD studentship (Louisa Cockbill) "Control of astrocytoma (brain tumour) cancer cell

motility and invasiveness by PICK1 and other actin regulators" Hanley J, Love S, 2011-

2015, £87,200.

27

Medical Research Council/Astra Zeneca. ET-1 mediated reduction of cerebral blood flow

in Alzheimer’s disease: therapeutic potential of zibotentan. Love S, Kehoe PG (Co-PI),

Paton JPR. 01/04/2013 - 31/03/2017: £526,622

NIHR-MRC. “Reducing pathology in Alzheimer’s Disease through Angiotensin TaRgeting —

The RADAR Trial”, Kehoe PG (PI), Ben-Shlomo Y, Montgomery A, Blair P, Passmore A,

Wilkinson I, Coulthard E, Kauppinen R. 01/01/2013 – 31/12/2016 : £1,944,906

Parkinson’s UK and Cure Parkinson’s Trust. A Randomised, Double-blind Trial to Assess

the Safety and Efficacy of Intermittent Bilateral Intraputamenal Glial Cell Line Derived

Neurotrophic Factor (GDNF) Infusions Administered via Convection Enhanced Delivery

(CED) in Subjects with Parkinson’s Disease. Alan Whone (PI), Steven Gill, Nik Patel, Lucy

Mooney, Elizabeth Coulthard, Andrew Lawrence, Stephen Daniels. £1.35 million - start

date to be established.

University of Bristol Home UK/EU Centenary Postgraduate Research Scholarship. Aβ

metabolism: changes with age in human brain. Love S, Kehoe PG (Co-PI). 01/10/2010 -

30/09/2013 : £49,470

University Hospitals Bristol NHS Trust Flexibility and Sustainability Fund Pump Priming

grant. “Exploring ‘Polypill’ options to treat dementia”, Kehoe PG (PI), Martin R.

01/04/2012 - 30/09/2012: £19,000

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Appendix B: Email regarding research activity survey 2014

Subject: Prioritising dementia HIT research and CLAHRC West

Hello,

As part of the dementia Health Integration Team (HIT), we have the opportunity to seek funding from Collaborations for Leadership in Applied Health Research and Care (CLAHRC) West. CLAHRC West will fund specific projects to bring together public health and NHS specialists with applied health scientist, commissioners and patients. We can only submit 1-2 projects per year from the HIT and so will have to prioritise and we already have several ideas. However, we wanted to make sure that we had consulted widely with people involved in dementia care and research about what research projects might be usefully supported by CLAHRC. So, we are contacting you to see if there are any ideas you think should be considered for this funding. If you want to, please send your thoughts on the attached word document to Lauren.Dennis@UHBristol.nhs.uk before 5pm on Tuesday 22nd April 2014.

When we have any ideas, a small group will meet to see which we can prioritise and we will also give feedback about other potential funding opportunities. The rationale for any decision will be available for scrutiny and discussed at the dementia research workstream meeting.

This is part of our wider research program for which we are trying to collate dementia research activity as a resource for people developing new projects and so that we can demonstrate local endeavours. Therefore, if you are undertaking dementia research, teaching or training, we would like to know the following information from you:

• Projects you are currently involved in (even early concepts), and details of any funding sources; • Publications in 2013/2014 or web links to lists if there are many; • Conference presentations and/or posters during 2013/2014, and any you have planned for 2014; • Supervision of student projects with a dementia focus (whether BSc, MSc, or PhD); • Dementia-related teaching, workshops or training events you ran in 2013/2014, and any planned for 2014. Feel free to use the attached document for this too, but we recognise that much of this information will be held in your current CVs. Therefore if it is more convenient for you to send your CV with a note of project concepts, then please do. If this email is not applicable to you at the moment, but you would like to carry out research or evaluation in the future can you please let us know so we can keep you informed of opportunities. Please forward this email to anyone else you think might want to contribute. Again, could all responses please be sent to Lauren.Dennis@UHBristol.nhs.uk(Management Assistant for the BHP) before 5pm on Tuesday 22nd April 2014. Best wishes Dr Elizabeth Coulthard Dementia HIT Co-Lead Director, http://www.bristolhealthpartners.org.uk/health-integration-teams/dementia-hit/ Consultant Senior Lecturer in Dementia Neurology, University of Bristol and North Bristol NHS Trust.

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Appendix C: Screen shot of word version of survey

30

Appendix D: Research ideas and priorities from survey

Name(s) Project idea and notes Notes/feedback

Projects prioritised for possible submission in the first round

Sarah Cullum/Sarah

Purdy

Interventions to prevent

inappropriate admissions to

secondary care

A joint HIT bid and could be linked to

work suggested for Sian Jones too.

Rik Cheston

Intervention and evaluation of

post-diagnostic care

Could be linked to Emily Dodd

suggestion too.

Projects for which more information is required that may possibly be suitable for submission to

CLAHRC in future rounds

Helen Bufton &

Paula Clough (OTs

with AWP)

Assistive Technology,

Wandering and the Cost Impact

to Public Services

More information required:

Is this technology already available?

What does it cost?

Who would provide it?

Could CLAHRC usefully review the

literature as to what is available etc?

In other words it is a question that is

potentially of interest to CLAHRC, but

the form of the research project is not

yet clear.

Karen Hillier

(Service Manager

AWP)

Comment, ‘I wonder if people

with dementia do better when

they are kept at home with

direct payment packages of care

or whether they survive longer

in Res care or Nursing

homes. My view is that we put

too many people into NH and

should be facilitating packages

in the community and accepting

psychologically as a society that

part of having an ageing

generation who will because of

medicine live longer and

This is a significant national issue and if

of interest to local commissioners may

be possible to investigate here. Plan –

send feedback to Karen Hillier and ask

commissioners if it is something they

would be interested in taking forward.

Note Emma Moody’s suggestion of

evaluating the new care home model in

Bristol – could they be tied together at

all?

31

therefore be subject to

dementia, that we need to

massively adjust to provide

sufficient services in both health

and social care as part of a day

to day community life whatever

that consists of.’

Matthew Yates

(Assistant

Psychologist with

AWP)

Comment, ‘I feel that our

progress on improving the lives

of those with dementia is an

example of an area where there

has been considerable growth

in our understanding, but a lack

of this being actively applied to

those it impacts i.e those with

dementia and their carers,

particularly in care homes. The

research into improving the

lives of those with dementia has

been excellent. We are now

fully aware of how we should be

treating and caring for those

with dementia in care homes,

however in practice this doesn’t

take place.

A large proportion of those with

dementia eventually move into

care homes. We are an aging

population, dementia and care

of those with dementia is a is

ticking time bomb for care

homes. I feel the best way to

make a positive change is to

build findings such as those

found by:

What makes a real difference to

resident experience? Digging

deep into care home culture:

The CHOICE (Care Home

Organisations Implementing

Cultures of Excellence) research

report by Anne Killett, Alison

More information needed. Plan – to ask

Matthew if he means that the

recommendations of Killett et al are not

being implemented. This could be

evaluated if there is a specific question.

32

Bowes, Dawn Brooker, Diane

Burns, Fiona Kelly, Jenny La

Fontaine, Isabelle Latham,

Martin O’Neill, Fiona Poland,

Michael Wilson.’

Projects not thought suitable for CLAHRC at present, but we would be happy to

discuss/reconsider

Mary Griffin

(DeNDRoN)

Enabling Research in Care

Homes (ENRICH)

This national initiative appears to be a

potential useful resource for projects

about which we should be informed.

We did not think it was a research idea

for CLAHRC as such.

Mary Griffin

(DeNDRoN)

Recruitment and Feasibility Tool

(RAFT). A rebranding is in

progress

This national initiative appears to be a

potential useful resource for projects

about which we should be informed.

We did not think it was a research idea

for CLAHRC as such.

Deborah Shoemark

(UoB)

A “Proof of Principle” project

using the biomarker DS is

developing to select five early

Alzheimer’s disease (AD)

patients for an intervention

lasting a year

This would not fall under the remit of

the CLAHRC although could be

reconsidered at a stage when the

intervention is being evaluated

potentially.

Subitha

Baghirathan

(Volunteer Bristol)

Supported Volunteering Project

for people with dementia

We weren’t sure of specific research

ideas that required input.

Robin Holmes

(UoB/UHBT)

This research is underway and does not

fall within the remit of the CLAHRC.

Kanch Sharma

(UoB)

Need specific project ideas for CLAHRC.

Patricia Holley

(UoB)

No specific project idea but

suggestion of SPHERE project

Happy to engage with SPHERE when

helpful.

33

linking with HIT

Seth Love (UoB) Comment, ‘I wonder whether

simply analysing the

demographic and existing

cognitive data for the full

(∼2,500 participant) BDR cohort

would be worth considering in

this context. Nobody has done

this yet. Apart from the fact

that it would be interesting to

find out how comparable this

self-referred group is to other

large cohorts of similar age

distribution, the data would be

invaluable for the planning of

any other studies on this

cohort.’

The CLAHRC will only support applied

health research questions

Jude Hancock PPI evaluation – how do we

best do it in dementia

This should be discussed with David

Evans in the first instance.

Jude Hancock Impact of Dementia Friends

initiative

Possible monies will be

available from Health Education

South West for this

More information required about the

initiative.