Renal Ultrastructure Atlas Wm. J. Hunter M. D.. How to Use This Atlas These photos are meant to...
-
Upload
corey-carroll -
Category
Documents
-
view
216 -
download
2
Transcript of Renal Ultrastructure Atlas Wm. J. Hunter M. D.. How to Use This Atlas These photos are meant to...
Renal Ultrastructure Atlas
Wm. J. Hunter M. D.
How to Use This Atlas
• These photos are meant to supplement your Jungueire text-atlas and Robbins by giving some different views.
• Generally I put an unlabeled photo on one page and the labeled view on the next. Try to identify the cells and structures first before looking at the labels.
• This atlas is posted in blackboard-- the resolution on screen is much better than in this handout.
• Please contact me if you have any questions.
Normal gomerulus
Epithelial cell(podocyte) parietal cell prox. tubule
Endothelial cell mesangial cell capillary lumen
Diagrammaticview of low power EM
Low power view ofNormal glomerulus
Low power view ofNormal glomerulus
Endothelial cell nucleus
Capillary lumen
Mesangial cell
Endothelial cell
Epithelial cell (podocyte)
Bowman’s space (urinarySpace)
Capillary lumen
RBC
Medium power EM ofa capillary loop
Medium power EM ofa capillary loop
Capillarylumen
Foot processes
Mesangial cell cytoplasm
Mesangial matrix
Parietal layer of bowman’scapsule
Urinary space
Endothelial cell nucleus
Endothelial cell fenestrations
Epithelial cell (podocyte)
Another capillary loop
Another capillary loop
Epithelial cell (podacyte)
Capillary lumen
RBC
Mesangial cell
Urinary space
The glomerular capillarybasement membrane
The glomerular capillarybasement membrane
Capillary lumen
Urinary space
Foot process
Epithelial cell
Endothelial cell
BM
Close up
of BM
Close up of Basement Membrane
Capillary lumen
Endothelial cell
fenestration
Lamina densa
Lamina raraexterna
Lamina rarainterna
Urinary space
Foot process
BM
Slit membrane
Epithelial cell
Proximal tubules- note hard to see cell borders
microvilli
Low power of proximaltubule
Low power of proximal tubule
Brush border
Tubular BM
InterdigitatedLateral process
Distal tubule
Distal tubule
lumenPlasma cell
Interstitial cell
Short villi
Collecting tubule/duct
Collecting tubule/duct
lumen
Classic Glomerular Disorders
• Please refer to these cases as we discuss them in class
• Think about the classic picture on light microscopy, immunofluorescence and electron microscopy and
• Explain the pathophysiology of the diseases
Acute proliferative
GN (post strep)
Acute proliferative
GN (post strep)
Hypercellular glomeruliIncreased # of cells
Normal glomerulus
IF showing “lumpy-bumpy” pattern
Minimal changedisease
Minimal changedisease
Minimal change disease “normal” glomerulus by light microscopy
Minimal changedisease
Minimal changedisease
Membranous nephropathy thickened BM
Membranous GN
Membranous GN
Membranous GN
Membranous GN
Membranous GN
Diffuse proliferative lupus GN (WHO class IV) all glomeruli involved
Endothelial, epithelial, & mesangial proliferation, thrombosis of Capillaries (note few capillary lumens seen)
IF in lupus nephritis anti-IgG
Proliferative lupus nephritis wire loop--subendothelial deposit
Lupus nephritis-Wire loops
Lupus nephritis-Wire loops
Lupus nephritis-Wire loops
Lupus nephritis-Wire loops
Lupus nephritis-Wire loops
Lupus nephritis-Wire loops
Lupus nephritis-Wire loops