Renal Supportive Care – an overview. Frank Brennan .... Brennan - Renal Supp… · QOL - St...
Transcript of Renal Supportive Care – an overview. Frank Brennan .... Brennan - Renal Supp… · QOL - St...
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2014
Renal Supportive Care – an overview. Frank Brennan, Palliative Care Physician.
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Renal Palliative Care – Caring for adult patients with ESKD – an overview
Frank Brennan
Palliative Care Consultant Department of Nephrology
St George Hospital Sydney, Australia
British Columbia Kidney Days, Vancouver, British Columbia, Canada October 2014
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A 53 year old woman
• Type 2 Diabetes Mellitus • Hypertension • OA – mild • ESKD – Diabetic Nephropathy • HD 3/week for 5 years
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• Shuffled in to the clinic room
• Head down
• No eye contact
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“My legs move all through the night” – Severe Restless Legs Syndrome - 2
years
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“I itch all the time… often it becomes ferocious” Severe uraemic pruritus – 3 years
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“My feet and calves burn and get pins and needles – it is
awful” Severe diabetic peripheral neuropathy – 18 months
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And sleep ?
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“I don’t sleep… I doze in 5 minute lots... “I sit on a chair and put my elbows on my knees to hold
them still… and I pray to die.”
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Overview
What is Palliative Care ?
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What role does Palliative Care have in Nephrology ?
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Withholding and withdrawing from dialysis
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What exactly is the conservative, non-dialytic management of ESKD ?
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Symptom management
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Care of the dying patient with ESKD
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Creating and nurturing a Renal Supportive Care service
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What is Palliative Care ?
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WHO definition (2002) Palliative Care is an approach which
improves the quality of life of patients and their families facing life-threatening illness, through the prevention and relief of suffering by means of early identification and impeccable assessment and treatment of pain and other problems, physical, psychosocial and spiritual.
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Myths There is virtually no common ground
for active treatment of disease and palliative care.
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Myths
That palliative care is simply the care of the dying
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Myths
That palliative care means giving up hope
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Modern view of Palliative Medicine A. Early involvement : “There is wide
recognition that the principles of palliative care should be applied as early as possible in the course of any chronic, ultimately fatal illness.”
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B. The concept of concurrent care : that active care and palliative care can and should occur together.
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C. That bringing in a palliative approach as the person is dying is a set of missed opportunities.
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Benefits of early involvement– - reinforcement of idea of
comfort. - that symptom control is impeccable throughout. - establishing a rapport/trust - demystifying analgesia (opioids) - introducing idea of Community Care - helps avoid sense of abandonment
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D. That palliative care can be applied to all life-limiting illnesses
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What possible role does Palliative Care play in End
Stage Kidney Disease ?
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1. Epidemiology
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DIALYSIS PATIENTS
In developed nations the characteristics of patients on dialysis have changed over the years. Essentially more elderly patients with co-morbidities.
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Number Starting Renal Replacement Therapy Dialysis or Transplantation Australia and New Zealand
0
100
200
300
400
500
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ient
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NZ
0
500
1000
1500
2000
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ient
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1960 1970 1980 1990 2000 2010 Year
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In western nations the mean age of commencement on Renal Replacement Therapy is 60 - 65 years.
Increasing number of patients returning to
dialysis after transplant failure.
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The age cohort that has the greatest prevalence is the
65-84 year old group. Canadian Organ Replacement Register (CORR) Report 2014
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The other aspect of this change which will be a rising
challenge globally is the rise of Diabetes Mellitus
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In Canada - Prevalent ESKD by primary diagnosis
Diabetes – 27.1 %
CORR Report 2014
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Does everyone who has ESKD commence dialysis ?
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In Australia, for every one patient with ESKD receiving Renal Replacement Therapy (RRT)
there is another who does not receive RRT
Australian Institute of Health and Welfare Research,
2011
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2. Mortality
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ESRD patients
Overall patients with ESKD with or without RRT have a reduced life expectancy compared to age-matched controls.
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DIALYSIS
For patients on dialysis 15.7 % die each year (CORR Report
2014)
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For those aged 75 years and older that figure is 25 % (CORR Report 2014)
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3. Symptomatology
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Patients with ESKD have a significant symptom burden
related to both the disease itself and other co-morbidities
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What are the common symptoms associated with ESKD ?
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The Prevalence of Symptoms in End-stage Renal
Disease : A systematic Review Murtagh FE et al. Advances in Chronic Kidney Disease Vol 14, No 1
(January) 2007; pp 82-99
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A Cross-sectional Survey of Symptom Prevalence in
Stage 5 CKD managed without Dialysis Murtagh FEM et al. J Pall Med (2007) 10;6:1266-1276
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SYMPTOM PREVALENCE Dialysis Conservative
FATIGUE/TIREDNESS 71% 75%
PRURITUS 55% 74%
CONSTIPATION 53%
ANOREXIA 49% 47%
PAIN 47% 53%
SLEEP DISTURBANCE 44% 42%
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SYMPTOM PREVALENCE Dialysis Conservative
ANXIETY 38 %
DYSPNEA 35 % 61 %
NAUSEA 33 %
RESTLESS LEGS 30 % 48 %
DEPRESSION 27 %
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• Symptoms are prevalent
• Symptoms are multiple
• Symptoms are burdensome
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The management of symptoms are challenging
with the altered pharmacokinetics of most medications in
renal impairment
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4. Quality of life
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QOL - St George dialysis (SF-36 Scores)
0102030405060708090
100
PF RP BP GH VT SF RE MH
Mea
n sc
ore
(max
100
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20012003200420062008Aust Norms
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5. The “quality” of dying
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Realistically, given issues of manpower, it may not be possible for a Palliative Care health
professional to be present in every Renal Unit
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What are the core competencies in a “Palliative approach”
to patients with ESKD for medical practitioners ?
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4 Pillars of a Palliative approach
• Communication
• Symptom management
• Psychosocial support
• Care of the dying patient
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Communication
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Once ESRD is diagnosed it is important examine the
various options
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RRT Conservative
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Decision making around dialysis
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Survival
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Dialysis or not ? A comparative study of survival of patients over 75 years with CKD Stage 5.
Murtagh FEM et al. Neprol Dial Transplant 2007;22:1955-1962
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Murtagh et al. NDT. 2007;22:1955-62
Survival
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Murtagh et al. NDT. 2007;22:1955-62
Survival benefit lost if Co-morbidities include IHD
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RRT v Conservative Chandra et al NDT Nov 2010
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Dialysis in Frail Elders — A Role for Palliative Care
Robert M. Arnold, M.D., and Mark L. Zeidel, M.D.
Next
Volume 361:1597-1598 October 15,
2009
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Change in Functional Status after Initiation of Dialysis
Kurella Tamura et al. 361 (16): 1539, October 15, 2009
3702 Nursing home residents mean age 73 Mean eGFR 10 Female 60% Diabetes 68% CHF 66% CHD 44% Cerebrovascular dis. 39% Depression 35% Dementia 22%
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Smoothed Trajectory of Functional Status before and after the Initiation of Dialysis and Cumulative Mortality Rate
Kurella Tamura et al. 361 (16): 1539, October 15, 2009
[Nursing home residents mean age 73]
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Clinical Practice Guidelines on Shared
Decision-Making in the Appropriate Initiation of and Withdrawal from Dialysis
Renal Physicians Association of the USA 2010.
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Recommendation No. 6
It is reasonable to consider forgoing dialysis for … ESRD patients who have a very poor prognosis or for whom dialysis cannot be provided safely.
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1.Those whose medical condition precludes the technical process of dialysis because the patient :
(a) is unable to co-operate (eg. Advanced Dementia) (b) unstable medically (eg. Significant hypotension)
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2. Another life-limiting illness – although this may be
negotiated
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3. Over 75 years with 2 or more of the following statistically significant criteria predictive of very poor prognosis :
(a) Surprise question. (b) High Co-morbidity Score (c) Significantly impaired Functional status
such as Karnofsky < 40, (d) Severe chronic malnutrition (s. Albumin
< 25.)
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Conservative management of ESRD
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This may be decided in consultation with a Nephrologist, or The patient is not referred to a Nephrologist in the first place
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What level of care occurs for this group ?
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If this is being raised as an option :
What does a Conservative pathway mean ?
What is its content ? Can we make predictions about their course ?
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Challenge is to ensure that this pathway of management is not seen
as “second best” or inadequate
but is thorough, systematic and evidenced-based
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Renal Medicine Palliative approach Blood Pressure Calcium/Phosphate Symptom management Anaemia Psychosocial support Fluid balance Care of the dying
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There is a modest, but growing body of literature of
research on this cohort of patients.
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Centre for Palliative Care – Enhancing care through excellence in education and research
Australian & New Zealand Society of Palliative Medicine
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Centre for Palliative Care – Enhancing care through excellence in education and research
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Centre for Palliative Care – Enhancing care through excellence in education and research
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Australian & New Zealand Society of Palliative Medicine
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Symptom management
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SYMPTOM PREVALENCE Dialysis Conservative
FATIGUE/TIREDNESS 71% 75%
PRURITUS 55% 74%
CONSTIPATION 53% ANOREXIA 49% 47%
PAIN 47% 53%
SLEEP DISTURBANCE ANXIETY DYSPNEA NAUSEA RESTLESS LEGS DEPRESSION
44% 42% 38 % 35 % 61% 33 % 30 % 48 % 27 %
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Symptom control is challenging
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Symptoms interact and compound each other
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Nocturnal :
U.Pruritus RLS Insomnia Fatigue Pain
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Symptoms may derive from the co-morbidities
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ESKD constrains the use of medication
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Pharmacology in the context of CKD is complex
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Multiple gaps in knowledge
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Recommendations in published data occasionally conflict
on the specific doses of medications to be used.
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Principles of symptom management
1. Think of the cause(s). 2. Be meticulous 3. Principle of non-abandonment
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PAIN
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Impact on QOL
Davison (2002) 69 dialysis patients 62% stated that pain interfered with their ability to
participate and enjoy recreational activities. Am J Kid Diseases 2003; 42(6): 1239-1247
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51 % stated that pain caused them “extreme suffering”
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41 % stated that pain caused them to consider ceasing
Dialysis
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Positive correlation with depression Davison S, Jhangri GS. J Pain Symptom Management 2005; 30(5): 465-473
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Causes of Pain
ESRD Co-morbidities and its treatment
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ESRD and treatment Disease related : • Polycystic Kidney Disease • Renal Bone Disease • Amyloid • Calciphylaxis
Dialysis-related pain : • PD pts with recurrent abdominal pain • AV Fistulae > ‘Steal syndrome’ • Cramps
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Co-morbidities
• OA
• Diabetic neuropathy
• PVD / IHD
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Pain etiquette
• ENQUIRE REGULARLY
• RESPOND COMPASSIONATELY
• TREAT COMPETENTLY
• REFER WISELY
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Principles of pain management
1. Always enquire about pain. 2. Treat the underlying cause of the pain. 3. Treat the pain meticulously. 4. Treat the pain proportionately. 5. Constantly reassess.
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Step 1
Acetaminetophen
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“It is considered the non-narcotic analgesic of choice for mild-moderate pain in CKD patients.”
Davison S, Ferro CJ. Management of Pain in CKD. Progress in Palliative
Care 2009; 17: 186-195.
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Acetaminophen at conventional doses is safe = 1 g qid
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Step 2
Tramadol
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Step 2
Tramadol “is the least problematic of the Step 2
Analgesics for ESRD patients” Nevertheless use with caution – use a bd dose.
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90 % of Tramadol and its metabolites are Renally
excreted
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Need for dose adjustment
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If on Dialysis or on Conservative pathway eGFR 15-30 Commence 50mg bd Maximum 100mg bd
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If on a Conservative pathway eGFR < 15
Tramadol 50mg bd (maximum)
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Step 3
Morphine
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Morphine
Hepatic metabolism
M-3-G M-6-G
Kidneys
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Morphine is not recommended in CKD
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Oxycodone Short-acting Long-acting Endone Oxycontin Oxynorm
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“Overall consensus is that Oxycodone is reasonably safe to use in CKD if monitored carefully.”
Davison SN et al Seminars in Dialysis 2014
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Fentanyl
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• Metabolised in Liver
• Inactive metabolites
• 5-10 % excreted unchanged renally
• Fentanyl is not dialysed
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Fentanyl is safe to use at standard doses
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Methadone
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• Metabolised in liver
• Excreted mainly in the feces. Some renal excretion of Methadone and its metabolites
• Not dialysed
• Safe to use, but requires skill in dosing regimen – specialist use.
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Davison SN, Konicki H, Brennan FP. Pain in Chronic Kidney Disease : A Scoping Review. Seminars in Dialysis 2014; 27(2): 188-204.
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RESTLESS LEGS SYNDROME
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Definition
1. An urge to move the limbs, usually associated with parasthesias/dysthesias
2. Motor Restlessness 3. Symptoms exclusively while at rest, with
relief (completely or partially) with movement.
4. Symptoms worse at night. International RLS Study Group – Definition of RLS (1995)
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Incidence in the general population : 2-15 %
Incidence in ESRD : 20-30 %
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Mechanism is not completely understood
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Fe
TH Tyrosine L-Dopa Dopamine DR2
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Fe
TH Tyrosine L-Dopa Dopamine DR2
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Management
Clonazapem 0.5mg – 1mg nocte
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Dopamine agonists
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• Ergot-Dopamine Agonists (Pergolide, Cabergoline)
• Non-Ergot Dopamine Agonists (Pramipexole, Ropinirole, Rotigotine)
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Gabapentin
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Two Level 1 studies have shown efficacy for Gabapentin in the treatment of RLS in Dialysis patients
• Study A – Placebo controlled – Thorp et al (2001)
• Study B – Gabapentin compared to Levo-
dopa – Micozkadioglu et al (2004)
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On Dialysis
Gabapentin 100mg after each Dialysis and titrating to effect
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On conservative management with eGFR < 15
Gabapentin 100mg every second night and titrating to effect
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On conservative management with eGFR > 15
Gabapentin 100mg nocte and titrating to effect
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URAEMIC PRURITUS
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Associations • Poor sleep quality
• Depression
• QOL
• Mortality Pisoni RL, Wikstrom B et al. Neprol Dial Transplant 2006; 21: 3495-
3505.
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The pathogenesis of pruritus
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Epidermis Dermis
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Complex neural network within the dermis and nerve
fibres enter the Epidermis as free nerve endings
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Brain
Thalamus
Spinal Cord
Peripheral Nerve
Stimuli
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C Fibres
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5 - 10 % of the C fibres are itch sensitive
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For many years the assumption was :
Histamine C Fibres Spinal Cord
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Of the C Fibres that are itch-sensitive :
20 % are Histamine-sensitive
80 % are Histamine-insensitive
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Myth 1
That all itch is histamine mediated
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Myth 2
That the best first line medication for pruritus of whatever cause are Anti-Histamines
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Pathogenesis of Uraemic Pruritus
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Multiple theories, conflicting findings
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“Despite this vast array of possible explanations, none consistently have been demonstrated to be the underlying cause of pruritus associated with CKD. Large epidemiological studies ultimately may facilitate our understanding of the elusive pathophysiological process of this distressing symptom.”
Patel TS et al. Am J Kidney 2007; 50(1): 11-20.
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Large number of therapies described
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What therapies have the strongest foundation in evidence – based practice ?
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• Oral medications
• Topical preparations
• UV Therapy
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Gabapentin
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There are 3 (three) Level 1 studies showing that Gabapentin has significant efficacy in treating uraemic pruritis
Gunal et al (2004) Naini et al (2007) Razeghi et al (2009)
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Evening Primrose Oil
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Gabba Linolenic Acid (GLA)
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Essential Fatty Acids (EFA) in the epidermis
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n- 6 EFA
Linolenic Acid (LA)
Gabba –Linolenic Acid (GLA)
DGLA Arachidonic Acid Adrenic Acid
Docosapentaenoic Acid
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n-EFA
Linolenic Acid (LA)
Gabba –Linolenic Acid (GLA)
DGLA PGE2 Arachidonic Acid (AA) Leukotriene B4 Adrenic Acid
Docosapentaenoic Acid
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n- 6 EFA
Linolenic Acid (LA)
Gabba –Linolenic Acid (GLA)
PGE1 DGLA 15 OH DGLA Arachidonic Acid (AA) Adrenic Acid
Docosapentaenoic Acid
PGE1 15 –OH DGLA
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So supplementing the Gabba-Linolenic Acid (GLA) has
an anti-inflammatory/ anti-itch effect
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100mg bd = Evening Primrose Oil contains GLA = 2 capsules bd
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Thalidomide 100mg nocte
Silva SR. Nephron 1994; 67(3): 270-273
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Other oral medications
• Anti-Histamines – evidence does not support use.
• Ondansetron – conflicting results. Not recommended.
• Cimetidine – not recommended • Naltrexone – conflicting results. Not
recommended. Murtagh FEM, Weisbord D . Symptom management in Renal
Failure. In : Chambers EJ et al (eds). Supportive Care for the Renal Patient. 2nd ed. 2010. OUP. p. 120
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Topical preparations
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Capsaicin cream (0.025 %)
Side effect – transient “burning” feeling on the skin
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UV-B Therapy
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Hassan H et al. Efficacy and Safety of Gabapentin for Uremic Pruritus and Restless Legs Syndrome in Conservatively Managed Patients With Chronic Kidney Disease J Pain & Symptom management 2014 (In Press)
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Of all CKD patients on a conservative pathway who presented to the RSC clinic with uraemic pruritus 47 % reported its severity as severe to overwhelming.
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At Clinic 4 (median 12.6 weeks) -
85 % reported nil to slight pruritus and no patients reported severe or overwhelming severity.
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A 53 year old woman
• Type 2 Diabetes Mellitus • Hypertension • OA – mild • ESKD – Diabetic Nephropathy • HD 3/week for 5 years
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Referred to clinic because of extreme :
1. Uraemic Pruritus 2. Restless Legs Syndrome 3. Diabetic PN 3. Very poor sleep
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Gabapentin
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Gabapentin commenced for all conditions at 200mg at
the completion of each dialysis.
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• Complete cessation of all symptoms and a markedly
improved sleep
• Sleeping “the best I have for a long time.”
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Care of the dying patient with ESKD
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ESKD patients may die :
• Having been on dialysis
• Never having been on dialysis
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Patients with ESKD on dialysis may die in many different ways
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The family’s view of the manner of
dying and the care given will have a major effect on their bereavement and will echo down the years in the way they view death.
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A major sentinel event Sudden death
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The “negotiated withdrawal”
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• George has been on dialysis for 6 months
• He is increasingly fatigued and more frail. No clear reversible cause.
• Further exacerbations of Chronic Airways Limitation.
• NSTEMI
• He presents with a gangrenous toe - post amputation, worsening gangrene… discussion about further surgery.
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Nephrologist 1
“Its time to talk to him and his family about the future. We need to be honest. It is right to say to him that he could withdraw from dialysis at any time, that would be OK. We would then speak about what to expect from that point onwards including our care for he and his family.”
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Nephrologist 2
“If he brings it up of course I will talk to him…but only if he raises it. It should come from him.”
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It is important that any discussion about withdrawal is open and honest at the patient’s own pace and includes the family.
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• What should I expect ?
• Will I suffer ?
• Will I drown in fluids ?
• How long will I live ?
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Patients survive a variable time.
• If completely anuric – 7-10 days
• If still passing urine – weeks-months
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HOPE
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The preservation and maintenance of hope
Resetting the focus of care I agree that there is no hope for cure,
but there is hope that you will be comfortable and supported throughout.
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Not be abandoned. Always be listened to. All symptoms treated to
the best of our ability. Will not needlessly
suffer. Treated with respect
and dignity at all times.
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“A crisis withdrawal”
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Scenario 1
The major sentinel event occurs …
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• Family prepared for imminent death
• Dialysis ceased
• Consensus that there will not be an escalation to ICU etc.
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Scenario 2
The major sentinel event occurs…
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• No discussion about withdrawal
• Waiting approach
• Patient dies on dialysis, the day of dialysis
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This scenario is considerably assisted if there the patient has had prior conversations with their Nephrologist including an Advance Care Plan
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Creating and nurturing a Renal Supportive Care service
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St George Hospital, Sydney, Australia
Collaboration between the departments of Renal Medicine and Palliative Medicine.
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Formation of a Renal Supportive Care Clinic March 2009
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• Held every week
• Held in the Renal Unit
• Palliative Care Consultant, Advanced Trainee in Renal Medicine, Renal Clinical Nurse Specialist and Renal Social Worker
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All patients with ESKD according to needs
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Main categories of patients who are referred to the clinic :
• Patients who are on a conservative pathway
• Patients who need assistance in decision
making around choosing dialysis or not
• Patients who are on dialysis and have cancer or other terminal conditions.
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• Patients on dialysis who are experiencing symptoms which are difficult to manage
• Patients on dialysis who need assistance in decision making regarding withdrawing or continuing with dialysis
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• Focus on symptom management
• Psychosocial support
• Preliminary discussions on ACP
• Access to Renal Social Worker and Renal Dietician
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Teaching programme for Junior Medical Staff, including Nephrology Trainees on all aspects of Renal- Supportive Care
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Preparation of documents :
(a) End of Life Pathway for Renal Patients
(b) Commonly used Palliative medications in the context of CKD
(c) A Renal-Palliative Care Reader
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Annual Renal Memorial Service
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Annual Renal Palliative Care Symposium
2010 - 2014
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Renal Supportive Care Curriculum - Master classes for trainees
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What are the best books and materials in this area ?
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Chambers EJ, Germain M, Brown E (eds) Supportive Care for the Renal Patient 2nd edition, 2010 Oxford University Press
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Brown E, Murtagh F, Murphy E.(eds) Kidney Disease –
From Advanced Disease to Bereavement. 2nd ed, 2012. Oxford Handbooks.
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Clinical Practice Guideline on Shared Decision-Making in the Appropriate Initiation of and Withdrawal from Dialysis
Renal Physicians Association of the USA and the American Society of Nephrology. 2010.
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Australasian Renal Supportive Care
Position Statement Endorsed by Kidney Health Australia Endorsed by the Australian and New Zealand Society of
Nephrology Nephrology 2013;18(6)
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End-of-life Framework : Recommendations for a Provincial EOL Care Strategy 2009 Work of the BC Provincial Renal Agency
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Conclusion
A mutual acknowledgement of need- The role of Palliative Care/supportive care in ESRD
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The last decade has seen considerable levels of advocacy, attitudinal shift, research, publications and collaboration
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This approach may come at multiple points in the
trajectory of the disease
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The core competencies in a “Palliative approach” to
patients with ESKD can and should be acquired by all doctors working with
these patients.
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Applies to patients who are being managed either with
dialysis or conservatively
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The family will remember forever your involvement, your
demeanour and your compassion
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Your patients remain your patients until their death