Regulation of blood potassium
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Transcript of Regulation of blood potassium
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Introduction Potassium is the principal electrolyte (cation) of
intracellular fluid. Ninety percent of potassium is concentrated
within the cell ; only small amounts are contained in bone and blood.
Potassium balance is regulated through gastrointestinal tract absorption and kidneys excretion .
Damaged cells release potassium into the blood.
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Cont.. Potassium plays an important role in
nerve conduction, muscle function, acid-base balance and osmotic pressure.
Potassium controls the rate and force of contraction of the heart and, thus the cardiac output.
Evidence of a Potassium deficit can be noted on an ECG by the presence of a U wave.
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High sources of dietary potassium are Bananas Carrots Tomatoes Oranges Potatoes and sweet potatoes Broccoli Nuts
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Normal Serum Range of Potassium Normal serum potassium levels are
Adult: 3.5 – 5.2 mEq/L
Children (1 – 18 years): 3.4 – 4.7 mEq/L
Infants (7 days –year): 4.1 – 5.3 mEq/L
Neonates ( 0 – 7 days ): 3.7 – 5.9 mEq/L
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Hypokalemia A low potassium blood level is referred to
as hypokalemia. Hypokalemia is defined as a serum level of
less than 3.5 mEq/L . Hypokalemia is common in the old people. The most frequent cause of potassium
deficiency is GI loss.
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Causes of hypokalemia Diarrhea, vomiting, sweating Starvation, malabsorption Cystic fibrosis Severe burns Alcoholism, chronic Osmotic hyperglycemia Respiratory alkalosis Renal tubular acidosis..
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Symptoms & signs of hypokalemia1. Constipation2. Respiratory depression.3. Cardiac arrhythmias4. Mild hypokalemia is often asymptomatic5. Moderate hypokalemia causes muscular
weakness, myalgia, and muscle cramps 6. More severe hypokalemia causes flaccid
paralysis, hyporeflexia, and tetany.
- etc.
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Hyperkalemia
Hyperkalemia is defined as a serum level of more than 5.0 mEq/L
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Causes of hyperkalemia Drugs which block potassium excretion
(angiotensin converting enzyme [ACE] inhibitors and spironolactone).
Renal failure, dehydration, obstruction, and trauma.
Cell damage, as in burns, accidents, surgery, chemotherapy, DIC,
Addison’s disease. Uncontrolled diabetes, decreased insulin.
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Symptoms & signs of hyperkalemia1. Hyperkalemia can be asymptomatic
2. Nausea .
3. Fatigue and muscle weakness.
4. Tingling sensations.
5. Slow heart beat and weak pulse.
- etc.
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Hemolyzed blood may not be used. Leukocytosis, as occurs in leukemia, raises potassium levels.
A number of drugs raise potassium levels, especially potassium-sparing diuretics and nonsteroidal anti-inflammatory drugs, especially in the presence of renal disease.
We Can Determine the K+ in Blood (serum or Plasma ) ,Stool , Urine, CSF and Saliva.
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