Regulating The Cell Cycle. Warm Up – The Cell Cycle The cell spends 80% of the time in...

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Regulating The Cell Cycle

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Transcript of Regulating The Cell Cycle. Warm Up – The Cell Cycle The cell spends 80% of the time in...

Page 1: Regulating The Cell Cycle. Warm Up – The Cell Cycle The cell spends 80% of the time in _______________ and 20% of the time in ________________ What are.

Regulating The Cell Cycle

Page 2: Regulating The Cell Cycle. Warm Up – The Cell Cycle The cell spends 80% of the time in _______________ and 20% of the time in ________________ What are.

Warm Up – The Cell Cycle

•The cell spends 80% of the time in _______________ and 20% of the time in ________________

•What are the steps in mitosis?

Page 3: Regulating The Cell Cycle. Warm Up – The Cell Cycle The cell spends 80% of the time in _______________ and 20% of the time in ________________ What are.

Key Concept

•How is the cell cycle regulated?

•How do cells know when to divide?

•How do you heal when you break a bone?

Page 4: Regulating The Cell Cycle. Warm Up – The Cell Cycle The cell spends 80% of the time in _______________ and 20% of the time in ________________ What are.

Regulate the Cell Cycle

•Cyclin: A protein that regulates the cell cycle

•Tells the cell when to begin mitosis

Page 5: Regulating The Cell Cycle. Warm Up – The Cell Cycle The cell spends 80% of the time in _______________ and 20% of the time in ________________ What are.

Growth Factors

•Growth factors stimulate the growth and division of cells

•When is this important?

Page 6: Regulating The Cell Cycle. Warm Up – The Cell Cycle The cell spends 80% of the time in _______________ and 20% of the time in ________________ What are.

How Does a Cell Die?•1. Accident or injury

•2. Apoptosis: Programmed cell death

Page 7: Regulating The Cell Cycle. Warm Up – The Cell Cycle The cell spends 80% of the time in _______________ and 20% of the time in ________________ What are.

What is Cancer?

•How have we been affected by cancer?

•How are cancer cells different from other cells?

•Why doesn’t everyone get cancer?

Page 8: Regulating The Cell Cycle. Warm Up – The Cell Cycle The cell spends 80% of the time in _______________ and 20% of the time in ________________ What are.

Cancer•Cancer: Uncontrollable cell growth

•Cancer cells don’t respond to signals that regulate growth of cells

•Tumor: Mass of cells that divide uncontrollably

Page 9: Regulating The Cell Cycle. Warm Up – The Cell Cycle The cell spends 80% of the time in _______________ and 20% of the time in ________________ What are.

What Causes Cancer?•Defects in genes that regulate cell growth and division.

•Sources?

•Defect in gene p53, which normally stops the cell cycle until all chromosomes are properly replicated.

Page 10: Regulating The Cell Cycle. Warm Up – The Cell Cycle The cell spends 80% of the time in _______________ and 20% of the time in ________________ What are.

How Cancers Spread: Metastasis

•Cancerous cells lose control and continue to grow & divide, producing tumors which can metastasize (spread to other parts of the body)

Page 11: Regulating The Cell Cycle. Warm Up – The Cell Cycle The cell spends 80% of the time in _______________ and 20% of the time in ________________ What are.

Think & Apply…•How are cancer cells different from normal cells?

•When researchers develop drugs, what characteristic of cancer cells do you think they target?

Page 12: Regulating The Cell Cycle. Warm Up – The Cell Cycle The cell spends 80% of the time in _______________ and 20% of the time in ________________ What are.

Cancer: A Disease of the Cell Cycle • Driving Question:

From what we explore about cell growth and the cell cycle, why doesn’t everyone get cancer?

• Essential skills:2.1 The student will analyze the steps of the cell life cycle, including replication, mitosis and meiosis and describe the significance of each.

• 2.2 The student will explain the process of tumor propagation and cancerous cell division.

• Overview:How does cancer arise? We will explore the effect of environmental and genetic factors on cancer and how cell cycle regulation can go wrong.

Page 13: Regulating The Cell Cycle. Warm Up – The Cell Cycle The cell spends 80% of the time in _______________ and 20% of the time in ________________ What are.

List of possible cancers:

• Colon CancerBreast cancer Lung cancerStomach cancerSkin cancer (melanoma)Hodgekin’s Lymphoma (immune system) Liver cancerLeukemia (blood)Prostate cancer Pancreas CancerColorectal Cancer (3rd most common)Brain cancerKidney Cancer


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