REFERENCE

1. Chien. YW, “Novel drug delivery systems, drugs and the Pharmaceutical sciences”,

Vol.50, Marcel Dekkar, New York, NY; 1992; 797.

2. Banker. G. S and Rhodes. C.T. “Modern pharmaceutics, third edition”, New York,

Marcel Dekkar, Inc., 1990.

3. Guy. RH. “Current status and future prospects of transdermal drug delivery, Pharm

Res 1996, 13, 1765-1769.

4. Finnin. BC, Morgan. TM “Transdermal penetration”. J Pharm Sci. Oct 1999; 88

(10):955-958.

5. Allen. LV, Popovich. NG, Ansel. HC. “Ansel’s Pharmaceutical Dosage Forms and

Drug Delivery Systems, 8th Edition, Lippincott Williams &Wilkins, 2005.pp. 298-315.

6. Barry B. “Transdermal Drug Delivery”. In Ed: Aulton M E, Pharmaceutics: The

Science of Dosage Form Design, Churchill Livingston.2002 pp: 499-533.

7. Sharma. N, Agarwal. G, Rana. AC, Bhat. Z, and Kumar. D: A Review: “Transdermal

Drug Delivery system: A tool for novel drug delivery system”. International Journal

of Drug Development and Research 2011; 3: 70-84.

8. Patel. RP and Baria. AH: “Formulation and evaluation considerations of transdermal

drug delivery system. International Journal of Pharmaceutical Research, 2011; 3: 1-9.

9. Vinod. KR, Sarvani. P, Banji. D and Teja. BB: “Transdermal drug delivery system

over coming challenges of popular drug delivery system”. International Journal of

Pharma World Research, 2010; 1: 1-14.

10. Barry BW: “Mode of Action of Penetration Enhancers on the Kinetics of

Percutaneous Absorption”. J. Control Release. 1987; 6: pp. 43-51.

11. Bodde. HE, I Van Den Brink, Koerten. HK: “Visualization Of In Vitro Percutaneous

Penetration of Mercuric Chloride Transport through Intercellular Space versus

Cellular Uptake through Desmosomes”. J Control Release. 1991; 15: 227–236.

12. Scheuplein RJ. “Mechanism of percutaneous absorption. 1. Routes of penetration

and the influence of solubility”. J Invest Dermatol, 1965; 45:334–346.

13. Kapoor. D, Patel. M and Singhal. M: “Innovation in transdermal drug delivery

system”. International Pharmaceutical Science, 2011; 1(1): 54-61.

14. Kumar Ritesh, Philip Anil: “Modified transdermal technologies: Breaking the

barriers of drug permeation via the skin”. Tropical Journal of Pharmaceutical

Research, 2007; 6 (1): 633-644.

15. Ahad. A, Aqil. M, Kohli. K, Sultana. Y, Mujeeb. M and Ali A: “Transdermal drug

delivery: the inherent challenges and technological advancements”. Asian Journal of

Pharmaceutical Sciences, 2010; 5(6): 276-288.

16. Gaur. KP, Mishra. S, Purohit. S and Dave K: “Transdermal delivery System: A review.

Asian journal of Pharmaceutical and Clinical Research, 2009; 2(1):14-20.

17. Soni Mohit, Kumar Sandeep and Gupta Dr.GD: “Transdermal drug delivery: A novel

approach to skin permeation”. Journal of Pharmacy Research 2009; 2(8):1184-1190.

18. Naik. Aarti, Yogeshvar. N, Kalia Guy and Richard Guy H: “Transdermal Drug

Delivery: overcoming the skin’s barrier function”, 2009; 3(9):318-326.

19. Arunachalam. A, Karthikeyan, Vinay Kumar. D, Prathap. M, Sethuraman. S, Ashutosh

Kumar. S and Manidipa S: “Transdermal Drug Delivery System: A review”. Current

Pharma Research, 2010; 1(1):70-81.

20. Bharadwaj. Snigdha, Garg Vipin Kumar, Sharma PK, Bansal Mayank and Kumar

Nitin: “Recent advancement in transdermal drug delivery system”. International

Journal of Pharma Professionals, 2011; 2(1):247-254.

21. Rizwan. M, Aqil. M, Talegoankar. S, Azeem. A, Sultana. Y, Ali. A. “Enhanced

transdermal drug delivery techniques: an extensive review on patents”. Recent Pat

Drug Deliv&formul. 2009, 3(2):105-24.

22. Cheston. M, Berlin. “Clinical report- Alternative Routes of Drug Administration-

Advantages & Disadvantages (subject review”). Pediatrics 1997.

23. Rizwan. M, Aqil. M, Talegoankar. S, Azeem. A, Sultana. Y, Ali. A. “Enhanced

transdermal drug delivery techniques: an extensive review on patents”. Recent Pat

Drug Deliv&formul. 2009, 3(2):105-24.

24. Weiner. E, Victor. A, Johansson. ED: “Plasma levels of d-Norgestrel after oral

administration”. Contraception 1976, 14: 563-570.

25. Keith AD: “Polymer matrix consideration for Transdermal Devices”. Drug Dev Ind

Pharm. 1983, 9: 605-625.

26. Baker. W and Heller. J:”Material Selection for Transdermal Delivery Systems in

Transdermal Drug Delivery”, Developmental Issues and Research Initiatives,

J.Hadgraft and R.H.Guys, Eds. Marcel Dekker, Inc.,New York 1989 pp. 293-311.

27. Wiechers. J. “Use of chemical penetration enhancers in Transdermal drug delivery-

possibilities and difficulties”. Acta pharm. 1992: 4: 123.

28. Yamamoto. T, Katakabe. K, Akiyoshi. K, Kan. K and Asano. T. “Topical application of

Glibenclamide lowers blood glucose levels in rats. Diabetes res. Clin. Pract. 1990; 8:

19-22.

29. Al- Khamis. K, Davis. SS and Hadgraft. J. “Microviscosity and drug release from

topical gel formulations.” Pharm. Res. 1986; 3: 214-217.

30. Anon. “Transdermal delivery systems-general drug release standards.

Pharmacopeial Forum”, 1980; 14: 3860-3865.

31. Mayorga. P, Puisieux. F and Couarraze G. “Formulation study of a Transdermal

delivery system of Primaquine”. Int. J. pharm. 1996; 132: 71-79.

32. Deo. M.R, Sant. VP, Parekh. SR, Khopade. AJ and Banakar. UV. “Proliposomes-based

Transdermal delivery of levonorgestral”. Jour. Biomat. Appl. 1997; 12: 77-88.

33. Yan-yu. X, Yun- Mei. S, Zhi-Peng. C and Qi-nerg. P. “Preparation of silymarin

proliposomes; a new way to increase oral bioavailability of silymarin in beagle dogs.

Int. pharm. 2006; 319: 162-168.

34. Crawford. R.R and Esmerian. O.K. “Effect of plasticizers on some physical

properties of cellulose acetate phthalate films”. J. Pharm. Sci. 1997; 60: 312- 314.

35. Kimball's Biology Pages, "Cell Membranes." Stryer S. Biochemistry, 1981, 213.

36. Vyas. S.P. & Khar. R.K. “Targeted & controlled drug delivery: Novel carrier

system”. CBS publishers and distributors, 2007.

37. Touitou. E, inventor. “Composition of applying active substance to or through the

skin”. US patent 1996; 5 540 934.

38. Patel. S, “Ethosomes: A promising tool for transdermal delivery of drug”, Pharma

Info.Net, 2007. 5(3).

39. Touitou. E, Dayan. N, Bergelson. L, Godin. B, Eliaz. M, “Ethosomes novel vesicular

carriers for enhanced delivery: characterization and skin penetration properties”, J

Control Release, 2000; 65, 40.

40. Merdan. VM, Alhaique. F and Touitou. E: “Vesicular carriers for topical delivery”.

Acta Techno. Legis Medicament, 1998; 12:1-6.ibution ability in stratum corneum.

41. Touitou, E. “Composition of Applying Active Substance to or Through the Skin”. US

Patent: 1996; 5716638.

42. Touitou, E. “Composition of Applying Active Substance to or Through the Skin. US

Patent: 1998; 5540934.

43. Touitou. E, Dayan. N, Bergelson. L, Godin. B, Eliaz. M. “Ethosomes - Novel Vesicular

Carriers for Enhanced Delivery: Characterization and Skin Penetration Properties.

J. Cont. Rel, 2000; 65:403-418.

44. Margarita. S, Touitou. E. “Buspirone transdermal administration for menopausal

syndromes, in vitro and in animal model studies”. Int. J. Pharm, 2010; 387:26-33.

45. Naggar. V.F, Khalafallah. N.M: “Lipid vesicles for skin delivery of drugs”: Reviewing

three decades of Research International Journal of Pharmaceutics 2007; 332(1-2):1-16

46. Laib. S, Routh. AF. “Fabrication of Colloidosomes at low temperature for the

encapsulation of thermally sensitive compounds”. J. Colloid & Interface Sci. 2008;

317: 121-129.

47. Swarnlata. S, Rahul. R, Chanchal. D.K, Shailendra. S: “Colloidosomes an advanced

vesicular system in drug delivery”. Asian J.Sci. Research 2011; 4(1): 1 – 15.

48. Dinesh. D, Amit. AR, Maria. S, Awaroop. R L, Mohd Hassan. G D. “Drug vehicle

based approaches of penetration enhancement. Int. J. Pharm. Pharm”. Sci. 2009;

1(1): 24 – 45.

49. Verma. DD, Fahr. A: “Synergistic penetration effect of ethanol and phospholipids on

the topical delivery of cyclosporine”. J.Cont. Release. 2007; 97(1): 55 – 66.

50. Dubey. V, Mishra. D, Jain. NK: “Melatonin loaded ethanolic liposomes:

Physicochemical characterization and enhanced transdermal delivery”, Eur J Pharm

Biopharm, 2007, 67, 398-405.

51. Jain. S, Tiwary. AK, Sapra. B, Jain. N: “Formulation and evaluation of ethosomes for

transdermal delivery of lamivudine”, AAPS Pharm Sci Tech, 2007, 8, 1-9.

52. Touitou E: “Compositions for applying active substances to or through the skin”. US

Patent 5 538, 934, 19.

53. Maghraby. G.M.M, Williams A.C, Barry B.W: “Oestradiol skin delivery from ultra

deformable liposomes: refinement of surfactant concentration”. Int. J. Pharm. 2000;

pg 63-74.

54. Fry. DW, White J.C, Goldman I.D: “Rapid secretion of low molecular weight solutes

1from liposomes without dilution”. Anal. Biochem. 1978; 90: 809- 815.

55. New RRC: “Preparation of liposomes and size determination, In: Liposomes A

Practical Approach, New RRC (Ed.)”, Oxford University Press, Oxford. 1990; 36-3.

56. Cevc. G, Schatzlein. A, Blume. G. “Transdermal drug carriers: Basic properties,

optimization and transfer efficiency in case of epicutaneously applied peptides”. J.

Control. Rel. 1995; 36: 3-16.

57. Berge. V, Swartzendruber. VB, Geest. J. “Development of an optimal protocol for the

ultra structural examination of skin by transmission electron microscopy”. J.

Microsc. 1997; 187(2): 125-133.

58. Toll. R, Jacobi. U, Richter. H, Lademann. J., Schaefer. H., Blume. U. “Penetration

profile of microspheres in follicular targeting of terminal hair follicles”. J. Invest.

Dermatol. 2004; 123: 168-176.

59. Lauer. AC, Ramachandran. C, Lieb. L.M, Niemiec. S, Weiner. ND. “Targeted delivery

to the pilosebaceous unit via liposomes. Adv. Drug Delivery 1996; 18: 311-324

60. Johnsen. SG, Bennett. EP, Jensen. VG Lance, “Therapeutic effectiveness of oral

testosterone”. 1974; 2:1473-1475.

61. Jain. S, “Vesicular approaches for transdermal delivery of bioactive agent”. Ph.D

thesis, Dr. H.S. Gour University, Sagar, India, 2005.

62. Tuting. TH, Storkus. WJ, Falo. J. “DNA Immunization Targeting the Skin: Molecular

Control of Adaptive Immunity J”. Invest. Dermatol. 1998; 111:183-188.

63. Fang. J, Hong. C, Chiu. W, Wang. Y. “Effect of liposomes and niosomes on skin

permeation of enoxacin.”

64. Nikalje. Anna. Pratima*, Tiwari. Shailee, “Ethosomes: A Novel Tool for Transdermal

Drug Delivery”. International Journal of Research in Pharmacy and Science, 2012;

2(1),1-20.

65. Celia. C., Cilurzo.F, Trapasso. E., Cosco. D, Fresta. M, Paolino. D. “Ethosomes and

Transferosomes Containing Linoleic Acid: Physicochemical And Technological

Features Of Topical Drug Delivery Carriers For The Potential Treatment Of

Melasma Disorders. Biomed microdev, 2011; 6:105-111.

66. Touitou E, inventor. “Composition of applying active substance to or through the

skin”. US patent 5 540 934. July 30, 1996.

67. Patel S, Ethosomes: “A promising tool for transdermal delivery of drug”, Pharma

Info.Net, 2007; 5(3).

68. Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M: “Ethosomes novel vesicular

carriers for enhanced delivery: characterization and skin penetration properties, J

Control Release, 2000; 65: 40

69. Merdan VM, Alhaique F, and Touitou E, “Vesicular carriers for topical delivery”. Acta

Techno. Legis Medicament, 1998;12:1-6.ibution ability in stratum corneum

70. Ventakraman. S, Awini. WM, Jorden. K and Kahmant: “Pharmacokinetics of two

alternative dosage forms of cyclosporine: liposomes and Intra lipid”, J Pharma Sci

1990; 79 (3): 216-219.

71. Junginer. HE, Hofland. HE and Bouwrtra. JA. Pharm Ztg 1991; 136: 9-24.

72. Natasa. S, Cajokovac. M and jalsenjak. L: “liposomes with clindamycin hydrochloride

in the therapy of acne vulgaris”. Int j Pharma, 1992; 85:97-101.

73. Reddy. N, Pandey. S and Udupa. N: “Improvement in bioavailability of flubiprofen in

topical delivery”, Ind J Hosp Pharm 1993; 30: 113-114.

74. Raja Naresh. RA, Singh. UV, Udupa. N & Pillai. GK: “Encapsulation of diclofenac

sodium in Niosomes”, Ind Drug 1993; 30: 275-276.

75. Arnardottir. HB, Sveinsson. SJ & Kristmundsdotir. T: “The release of clindamycin

Phosphate from a suspension of different types of liposomes and selected topical

dosage forms”, Int.J.Pharm 1996; 134: 71-77.

76. Bhavana Vora, Khopade. AJ & Jain. NK: “Niosome based transdermal system for

contraceptive delivery”, IPC Abstract 1996; AP 59: 41.

77. Khandare. JN, Jiwandal. BH & Uppal. RR: “Preparation and evaluation of

nimuesulide niosomes for topical delivery”, Int.drug 2001 April; 38 (4): 197-202.

78. Satturwar. PM, Khandare. JN & Nanda .VS: “Niosomal delivery of ketoconazole” Ind

Drugs 2001 April; 38 (12): 620-624.

79. Amit Bhatia, Rajiv Kumar and Om Prakash Katre: “Tamoxifen in topical liposomes:

development, characterisation and in – vitro evaluation”, J Pharm Sci, 2004; 7(2):

252-259.

80. Chetoni. P, Rossi. S, Burgalassi. S, Monti. D, Mariotti and Snettone. MF: “Comparison

of liposomes –encapsulated acyclovir ointment: ocular pharmacokinetics in

rabbits”, J Ocular Pharmaco Thercop 2004 Apr; 22(2) 169-177.

81. Boutounne. LH, Guillaune. YC, Michel. L, Humbert. PH and Millet. J: “Study and

development of encapsulated forms of 4, 5, 8 – Tri methyl Prosatin for topical drug

delivery”, Drug Dev Res 2004; Feb 61 (2); 36-94.

82. Harwitz. E, Pisanty. S, Czemiski. R, Helser. M, Eliav. E and Touitou. E: “A chemical

evaluation of a novel liposomal carrier for acyclovir in the topical treatment of

recurrent herpes labialis”, Oral medicine 1999 Feb; 87: 700-708.

83. Touitou. E, Dayam. N, Bergelson. L, Goderin. B and Eliaz. M. “Ethosomes – novel

vesicular carrier for enhanced delivery: characterization and skin penetration

property “, J Con release 2000; 65: 403- 418.

84. Dayan. N and Touitou. E: “Carriers for skin delivery of Trihelyphenidyl HCl:

ethosomes Vs liposomes”, Biomaterials 2000; 21: 1879-1885.

85. Touitou, E., “Ethosomes novel vesicular carriers for enhanced delivery:

characterization and skin penetration properties”. J Control Release,2000; 65: 403

86. Lodzki. M, Godin. B, Rakou. L, Mechoulan. R, Gallily. R and Touitou. E:

“Cannabidiol- transdermal delivery and anti inflammatory effect in a murine

model”, J Control Rel 2003; 93: 377 – 387.

87. Godin. B and Touitou. E: “Mechanism of Bacitracin permeation enhancement

through the skin and cellular membranes from and ethosomes” Carrier control Rel

2000; 94; 365-379.

88. Jain. S, Umamaheswari. RB, Bhadra. O and Jain. NK: “Ethosomes Novel Vesicular

Carriers for enhances trandermal delivery of an anti HIV agent”, Indian J Pharm Sci

2004; 66 (1): 72-81.

89. Koshkela. RV, Kirjavainen. M, Monkkonen. J, Urthi. A and Kieswaara. J:

“Enhancement of percutaneous absorption of Naproxen by Phospholipids”,

Int.J.Pharm 1998; 175: 225-230.

90. Gondaliya. DP and Pundarikakasudu. K: Studies in formation, “characterisation of

Transdermal permeation of Nimuesulide from aq. and emulgel”, Ind Drug 2002; 39

(9); 465-473.

91. Sang – Chul. S, Hee – Jung. K, In-joon. O, Cheong- Weon C and Kyu-ho Y;

“Development of Tretinoin gels for enhanced Trandermal”, Eur J Pharma Biopharm

2005 may; 60 (1): 67-71.

92. Patel. MM, Sheth. MN and Harinawala. AI: “Studies in the transdermal formulations

of Metoprolol tartarate, a and their evaluation using human cadaver skin”, The east

Pharmacist 1993 Dec; 129-131.

93. Shahnaz Ahmed, Shamim Qureshi, Zulekha Kapadia and Yasmeen Badar. 1989

Pakisthan J Pharm Sci 1989; 2 Page 1-5.

94. Loidmann L, Vander Does R, Horrmann M, Machwirtn M, “Safety and

antihypertensive efficacy of carvedilol and atenolol alone and in combination with

hydrochlorothiazide”, Eur J Clin Pharmacol 1990: 38(2): 143 – 146.

95. Dr. R. Vanderdoes, L. Widmann, H.J Uber Bacher, M. Hormann, M. Mach Writh, U

Stienen: “Efficacy and safety of carvedilol in comparison with atenolol in

hypertensive patients are treated with hydrochlorothiazide” European Journal of

clinical Pharmacology 1990; 38 (2): P 147-152

96. Mandal. SC, Bhattacharya. M, Chattarraj. SC, Ghosh. SK: “Preparation of Matrix Type

Transdermal Devices of Diazepam”, Indian Drugs, July, 1991; 28(10), 478-80.

97. Senshang Lin, Yie W. Chien, Wen-Chu Huang, Chau-Hsian Li, Chin-Ling Chueh, Russel

Rhei-Long Chen, Te-Man Hsu, Tsang-Shann Jiang, Jhili Wu, and Kirti H. Valia

“Transdermal Nicotine Delivery Systems: Multi-institutional Cooperative

Bioequivalence Studies” Drug Development and Industrial Pharmacy, 1993; 19 (20):

2765-2793

98. Krishna R, Pandit J K: “Transdermal delivery of propranolol”, Drug Dev. Ind. Pharm,

1994; 20:2459–2465.

99. Calpena A C, Blanes C, Moreno J, Obach R, Domenech J: “A comparative in vitro

study of transdermal absorption of Anti Emetics”, J Pharm Sci, 83 (1), 1994; 29-33.

100. Gupta GD, Patel Patel, Amit Chaudhary and YS Tanwar: “In vitro permeation of

Repaglinide from polymeric membrane system across human cadaver system”.

Priory Medical Journals, 1995.

101. Mesiha Mounir S., Andronis Vlassios, Mesiha Mounir S. Plakogiannis Fotios M.

“Design and evaluation of transdermal chlorpheniramine maleate drug delivery

system” Pharmaceutics Acta Helvetiae,1995; 70: 301-306.

102. Cheong Hyun-Ah: “Effect of ethanolamine salts and enhancers on the percutaneous

absorption of Piroxicam from a pressure sensitive adhesive matrix, European

Journal of Pharmaceutical Sciences, 2003; 18: 149– 153.

103. Thacharodi. D and Panduranga Rao K: “Rate-controlling biopolymer membranes as

transdermal delivery systems for Nifedipine: development and in vitro evaluations”

Biomoteriols 17 (1996); 1307-1311.

104. Feldstein M.M, Tohmakhchi V.N, Malkhazov L.B, Vasiliev A.E, Plat N.A:

“Hydrophilic polymeric matrices for enhanced transdermal drug delivery”

International Journal of Pharmaceutics 131 (1996); 229-242.

105. Kale. P, Warrier, HC and Shrivastava R: “Preformulation stability and permeation

studies of Transdermal delivery of Salbutamol sulphate”, Indian Drugs, 1996, 33(5),

202.

106. Feuerstein G.Z, Ruffolo R.R: “Carvedilol a novel vasodilating beta blocker with the

potential for cardiovascular organ protection” Eur Heart J 1996 Apr; 17 suppl B: B

24- 29.

107. Max L, Yue TL, Lopez BL, Barone FC, Christopher TA, Ruffolo RR JR, Feuerstein

GZ: “Carvedilol a new beta adreno receptor blocker and free radical scavenger,

attenuates myocardial Ischemia, Reperfusion injury in hypercholesterolemia

rabbits”, J. Pharmacol Exp 1996; 277 (1); 128-136.

108. Cordero. JA, Alarcon. L, Escribano. E, Obach. R, Domenech. J: “A Comparative

study of the transdermal penetration of a series of Nonsteroidal anti-inflammatory

drugs”, J. Pharm. Sci. April, 1997: 86(4), 503-508.

109. Farinha Aseensao, Jain Amit Kumar, Thomas Narisetty Sunil, Panchagnula Ramesh,

“Transdermal drug delivery of imipramine hydrochloride. I. Effect of terpenes”

Journal of Controlled Release, 2002 79: 93–101.

110. Gye. JR, Jong. SW, Sung. JH, Young. WL, Chang. HL: “Topical Oleohydrogel

preparation of Ketoprofen with enhanced skin permeability”, Drug Dev. Ind Pharm

1999; 717-726.

111. Hock S, Tan and Williams R, Fistes: “Pressure sensitive adhesive for transdermal

drug delivery system”. PSTT 1999; 2(2): 60-69.

112. Pandey. S, Praveen. SH, Udupa. N: “Formulation and evaluation of Nimuesulide

transdermal drug delivery systems”, Ind. J. Pharm. Sci., Sep-Oct 2000; 62(5), 376-9.

113. Dayan. N, Touitou. E: “Carriers for skin delivery of trihexyphenidyl HCl:

ethosomes vs. liposomes”, Biomaterials 2000 Sep; 21(18): 1879 – 1885.

114. Touitou. E, Dayan. N, Bergelson. L, Goden. B, Eliaz. M: “Ethosomes novel vesicular

carriers for enhanced delivery: characterization and skin penetration properties”, J

Control Release 2000 Apr 3; 65 (3): 403 -418.

115. S.M.K. Rates: “Plants as source of drugs” Toxicon 2001; 39: 603-613.

116. Santoyo S: “Effect of skin pre treatment with fatty acids on percutaneous

absorption and skin retention of Piroxicam after its topical application”, European

Journal of Pharmaceutics and Bio pharmaceutics 50 (2000) 245-250.

117. Panchagnula. Ramesh Salve Pramod Sridhar, Thomas Narisetty Sunil, Jain Amit

Kumar, Poduri Ramarao: “Transdermal delivery of naloxone: effect of water,

propylene glycol, ethanol and their binary combinations on permeation through rat

skin”, International Journal of Pharmaceutics, 2001: 95–105.

118. Ting W.W, Sontheimer R.D: “Local therapy for cutaneous and systemic lupus

erythematosus: practical and theoretical considerations”, lupus 2001; 10 (3): 171-

184.

119. Shin. S and Leeh: “Enhanced transdermal delivery of Triprolidine from the

ethylene – Vinyl acetate matrix”. Eur J Pharm. Biopharm. 2002, 5; 161-164.

120. Kulkarni R.V, Mutalik. S, Hiremath. D: “effect of plasticizers on the permeability

and Mechanical properties of eudragit films for transdermal application”, Indian J

Pharm Sci 2002; 64 (1): 28 - 31.

121. Panigrahi. L and Ghosal. K: “Formulation and evaluation of transdermal drug

delivery system of Terbutaline Sulphate”. Int. J. Pharma. Sci. 2002; 113; 79-82.

122. Lipp Ralph, Funke Adrian Peter, Clemens Gu¨nther, Rainer Helmut Mu¨ller: “In-vitro

release and transdermal fluxes of a highly lipophilic drug and of enhancers from

matrix TDS” Journal of Controlled Release 82 (2002); 63–70.

123. Qvist Michael H, Hoeck Ulla, Kreilgaard BO, Flemming Madsen, Frokjaer Sven:

“Release of chemical permeation enhancers from drug-in-adhesive transdermal

patches” International Journal of Pharmaceutics 231 (2002) 253–263.

124. Palazzuoli P, Calabria M.S, Verzuri A, Auteri: Carvedilol: “Something else than a

simple blocker”, European review for medical and pharmacological sciences 2002; 6:

115 – 126.

125. Sankar. V, Johnson DB, Sivanand. V, Ravichandran. V, Raghuraman. S, Velrajan. G:

“Design and evaluation of nifedipine transdermal patches”, Indian J Pharm Sci 2003;

65(5): 510 – 5.

126. Devi K.V, Sai sivam. S, Maira G.R, Deepthi P.U. “Design & evaluation of matrix

diffusion controlled trandermal patches of Verapamil hydrochloride”, Drug Dev Ind

Pharm 2003; 29(5): 495 – 503.

127. Elvira, Ana CC, Joseph Q, Rossend O, Jose D: “Assessment of Diclofenac permeation

with different formulations, anti-inflammatory study of a selected formula”, Eur. J.

Pharm. Sci, 2003, 19,203-210.

128. Gwak. HS, Oh IS, Chun IK: “In-vitro percutaneous absorption of Ondansetron

hydrochloride from pressure-sensitive adhesive matrices through hairless mouse

skin”, Arch Pharm Res, 26 (8), 2003, 644-8.

129. Manvi. FV, Dandagi. P M, Gadad. A P: “Formulation of a Transdermal Drug

Delivery System of Ketotifen Fumarate”, Ind J Pharm Sci. 2003; 65(3):239-43.

130. Sankar. V, Sivanand. V, Ravichandran. V: “Design and evaluation of nifedipine

transdermal patches”, Ind J Pharm Sci. 2003; 65(5):510-15.

131. Jain. S, Sapre. Umamaheshari and Jain. MK: “Transferosomes for effective

transdermal delivery of Norgesterol Preparation and In Vivo Characterization”. Int.

J. Pharma. Sci. 2003; 65(2); 152-160.

132. Lodzki. M, Godin. B, Rakou. L, Mechoulam. R, Gallily. R, Touitou. E: “Cannabidiol –

transdermal delivery and anti inflammatory affecting a murine model”, J control

Releas 2003 Dec 12; 93 (3): 377 – 387.

133. Olivier J.C, Rabouan S, Couet W: “In vitro comparative studies of two marketed

transdermal nicotine delivery systems: Nicopatch and Nicorette” International

Journal of Pharmaceutics 252 (2003); 133–140.

134. Aquil. M , Sultana. Y and Ali “A Matrix type transdermal drug delivery system of

metoprolol tartrate: In Vitro characterization”, Acta pharma. 2003, 53: 119 - 125.

135. Brown Marc. B, Franklin Akomeaha, Nazir Tahir, Martin Gary P: “Effect of heat on

the percutaneous absorption and skin retention of three model penetrant” European

Journal of Pharmaceutical Sciences, 2004; 21: 337– 345.

136. Murthy. S, Narasimha, Shobha Rani R, Hiremath, K.L.K. Paranjothy: “Evaluation of

Carboxymethyl guar films for the formulation of transdermal therapeutic systems”

International Journal of Pharmaceutics, 2004; 272:11–18.

137. Amir Mehdizadeh, Taybe Tolite, Mohammad Reza Rouini, Sharyar Abash Zadeh, Farid

Dorkoosh: “Design and in vitro evaluation of new drug in adhesive formulation of

Fanatyl transdermal patches”. Acta Pharma 2004; 54: 301-317.

138. Adrian C, Williams and Brian W, Barry: “Penetration enhancers”. Adv Drug Delivery

Reviews 2004; 56: 603-618.

139. Aquil Mohammed 2004 “Matrix type transdermal drug delivery system of

metoprolol tartrate skin toxicity and invitro characterization” Ethopian

Pharmaceutical Journal 12 , P 53-60.

140. Parikh Darshan. K and Ghosh Tapash K: “Feasibility of Transdermal Delivery of

Fluoxetine” AAPS Pharm SciTech 2005; 6 (2), 144-149.

141. Jia Zan, Guoqiang Jiang, Ying lin, Fengping Tan, Fuxin Ding: “Transdermal delivery

of Piroxicam by surfactant mediated Electroporation” Tsinghai science and

technology, October 2005; volume 10, number 5, pp542-547.

142. Aquil. M, Zafer. S, Ali. A and Ahmads “Transdermal drug delivery of labetolol

hydrochloride: system development, in vitro ex vivo & in vivo characterization”,

Curr Drug Deliv, 2005. 2(2): 125-31.

143. Al-saidan. SM, Yellela. SR, Krishnaiah, Patro. S.S and Vemulapalli. S: “Invitro & in

vivo Evaluation of Guar Gum Matrix tablets for oral controlled Release of Water

Soluble Diltiazem Hydrochloride”. APPS Pharma Sci Tech. 2005: 6(1) : 5.

144. Jain. SK, Gupta. SP: “Effective and controlled transdermal delivery metoprolol

tartarate” JIPS 2005; 67 (3): 346-350.

145. Satturwar PM, Fulgele SV, Darle AK: “Evaluation of polymerized resin for the

formulation and development of transdermal drug delivery system: A technique

note”. AAPS Pharma Sci Tech 2005; 6(4): E649-654.

146. Sara nicoli, Paolo Colombo and Partizea Santi: “Release and permeation Kinetics of

Caffeine from bioadhesive transdermal films”. AAPS Journal 2005; 7(1): E218-E223.

147. Srinivas Mutalile, Udupa N: “Formulation development in vivo and in vitro

evaluation of membrane controlled transdermal system of Glibenclamide”. J Pharm

Sci 2005; 8(1): 26-38.

148. Ainbinder. D, Touitou. E: “Testosterone ethosomes for enhanced transdermal

delivery”, Drug delivery, 2005 Sep – Oct: 12 (5): 297-303.

149. Ammara H.O, Ghorab M, El-Nahhas S.A, Kamel R: “Design of a transdermal

delivery system for aspirin as an antithrombotic drug” International Journal of

Pharmaceutics 327 (2006); 81–88.

150. Lee Philip J., Ahmada Naina, Langer Robert, Mitragotri Samir, Shastri V. Prasad:

“Evaluation of chemical enhancers in the transdermal delivery of Lidocaine”

International Journal of Pharmaceutics 308 (2006); 33–39.

151. Gattani SG, Gaud RS, and Chaturvedi SC: “Formulation and evaluation of

transdermal films of chlorpheniramine maleate”, Indian Drugs, 2007; 44(1):27-33.

152. Aquil. M, Alia. Y Sultan: “In vivo characterization of monolithic Matrix type

transdermal drug delivery system of pinacidil monohydrate”: AAPS Pharma Sci

Tech 2006, 7: 61-65.

153. Mao. Z, Zhanz, Tang. G, Chen G, “A new copolymer membrane controlling

Clonidsine linear release in a transdermal drug delivery system”, Int.J.Pharm. 2006:

332: 1-5.

154. Gosh. B, Desai. BG, khanam J, Jamakandi. VG: “Recent trends in transdermal

cardiovascular therapy”. Indian Journal of pharmaceutical sciences. 2006; 68 (5): PP

556- 561.

155. Das. MK, Bhattacharya. A, Ghosal. SK: “Transdermal delivery of Trazodone

hydrochloride from acyclic films prepared from aqueous latex”, Indian J Pharm Sci

2006; 68 (1): 41-46.

156. Anna M, Workovich, Suneela Podduturi, William H, Doub, Ajaz S Hussaien, Lucinda

F, and Buhse: “Transdermal drug delivery system adhesion as a critical safety:

efficacy and quality attribute”. Euro J Pharma and Bio Pharma 2006; 6(4): 1-8.

157. Srinivas Mutalile, Udupa N, Kumar S, Agarwal S, Subramanian G, Ranjith AK:

“Glipizide matrix transdermal system for diabetes Mellitus: permeation in vivo and

preclinical studies”. Life Sci 2006; 79: 1568-1577.

158. Ubaidulla. U, Reddy. MV, Ruckmani. K: “Transdermal therapeutic system of

Carvedilol: effect of hydrophilic and hydrophobic matrix on in vitro and in Vivo

characteristics”, AAPS Pharmsci Tech. 2007; 8(1): Article 2.

159. Gattani. SG, Gaud. RS, Chaturvedi. SC: “formulation and Evaluation of

Transdermal films of Diclofenac sodium”, Int. J. Chem Tech Res.2010; 2(1).

160. Rao. YM, Gannu. R, Vamshi YV, Kishan. V: “Development of Nitrendipine

trandermal patches: In vitro & ex vivo characterization” Curr Drug Deliv 2007 : 4 :

69-76.

161. Agrawal. SS, Munjal. P, “Permeation studies of atenolol and metoprolol tartarate

form three different polymer matrices for transdermal delivery”, Ind J Pharm

Sci.2007: 535 -539.

162. Paul F. White, Henrik Kehlef, Joseph M, Thomas Schricker, Daniel.B.2007. “The Role

of the Anaesthesiologist in fast – track surgery from multimodal analgesia to

perioperative medical care”, 1 ARC 2007; 104 (6). pp 1380-1396.

163. Singh B.S and Kumar C.P. “Penetration enhancers for transdermal drug delivery of

Systemic agents”, J Pharm Res 2007: 6(2): 44-50.

164. Jain. S and Joshi, Suresh: “Development of Transdermal matrix system of Captopril

based on cellulose derivatives”, Pharmacology online 2007. 1: 379 – 390.

165. Gupta. A, Prajapati SM, Balamurugan. M, Singh. M, Bhatia. D: “Design and

development of a proniosomal transdermal drug delivery system for captopril”,

Trop J Pharm Res 2007; 6 (2): 687-693.

166. Ubaidulla. U, Reddy MVS, Ruckmani. K, Ahmad FJ, Khar R.K: “Trandermal

therapeutic system of carvedilol: effect of hydrophilic and hydrophobic matrix on in

vitro & in vivo characteristics”. AAPS Pharm Sci Tech 2007; 8(1): 613 – 20.

167. Murthy TEGK and Kishore V.S: “Effect of casting solvent and polymer on

permeability on permeability of propranolol hydrochloride through membrane

controlled transdermal drug delivery system”, Indian J Pharm Sci 2007; 69 (5): 646 –

50.

168. Ubaidulla U, Reddy MVS, Ruckmani K, Ahmad FJ, Khar RK: “Transdermal

therapeutic system of Carvedilol: effect of hydrophilic and hydrophobic matrix on

in vitro and in vivo characteristics”. AAPS Pharma Sci Tech 2007; 8(1): 2.

169. Troy Purvis, Michal E, Mattucci, M Todd Crisp Keith, Johnston and Roberto Williams:

“Rapidly dissolving Repaglinide powders produced by the ultra rapid freezing

process”. AAPS Pharm Sci Tech 2007; 8(3) 58: E1-E9.

170. Dubey. V, Mishra. D, Dutta. T, Nahar. M, Saraf. DK, Jain N.K. “Dermal and

transdermal delivery of an anti psoriatic agent via ethanolic liposomes”, J Control

release 2007 Nov 6; 123 (2): 148 – 154.

171. Dubey. V, Mishra. D, Jain N.K: “Melatonin loaded ethanolic liposomes:

physicochemical characterization and enhanced transdermal delivery”, Eur J Pharm

Biopharm, 2007 Sep; 67 (2): 398 – 405.

172. Wisler J.W, Dewire S.M, Whalen E.J, Violin J.B, Darke M.T, Ahns, Shenoy S.K,

Letkowitz R.J. “A unique mechanism of beta blocker action ; carvedilol stimulates

beta arresting signalling”: Proc nafl Acad Sci USA 2007 Oct 16; 104 (42): 16657 – 62 .

173. Weber MA, Julius.S, Kjeldsen.SE: “Blood pressure dependent and independent

effects of Anti hypertensive treatment on clinical events in the value trial”. Lancet.

2004; 363: 2049-2051.

174. Subheet Jain, Ashok K, Tiwary Bharathi Sapra and Narendra K, Jain: “formulation

and evaluation of ethosomes for transdermal delivery of lamivudine”, AAPS Pharm

Sci Tech 2007; 8(4) A 111.

175. Puglia Carmelo and Francesco B. “Effect of Polyunsaturated Fatty Acids and some

conventional Penetration Enhancers on Transdermal Delivery of Atenolol”. Drug

Delivery. 2008; 15: 107–112.

176. Wasim Aktar. MD, Dwaipayan Sengupta and Ashim Chowdary: “Impact of pesticides

use in agriculture their benefits & hazards” interduscip Toxicol, 2008; 2 (1).

177. Renc, Fang L, Ling L, Wang Q, Sihai: “Design and in vivo evaluation of an

indapamide transdermal path”. International Journal of Pharmaceutics 2008; 370: (1-

2): 129- 135.

178. Sanap GS, Dama GV, Hande AS, Karpe S.P, Nalawade SV, Kakade RS: “preparation

of transdermal monolithic systems of indapamide by solvent casting method and the

use of vegetable oils as permeation enhancer” . Int J Green Pharm 2008; 2: 129-133.

179. Murthy TEGK and Kishore V.S: “Effect of casting solvent on permeability of

antihypertensive drugs through ethyl cellulose films”, J Sci Ind Res 2008; 67: 147-50.

180. Subramanian. K, Sathya Priya LS, Jaya Prakash. S, Prabhu RS, Abirami. A,

Madhumitha. B: “An approach to the formulation and evaluation of trandermal DDS

of Isoxsuprine HCl”, Int J Pharm Sci Tech 2008; 1(1): 22 – 8.

181. Shinde A.J, Garala K.C, More H.N: “Development and characterization of

trandermal therapeutics system of Tramadol hydrochloride”. Asian J Pharm 2008; 2:

265 – 69.

182. Naseem Ahmad Charoo, Areeg Anwer Ali shansher, Kanchan Kohli Krishna Pillai,

Zivaur Rahman: Improvement in bioavailability of transdermal applied Flubiprofen

using Tulsi (Ocimum Sanatum) and Turpentine oil. J colloids and surfaces B:

Biointerfaes 2008; 65:300-307.

183. Bijaya Ghosh, Ashish Jain, Naresh Rajgor and B.G Desai: “Passive and Iontophoretic

permeation of Glipizide”. Euro J Pharm and Biopharm 2008; 69(3): 958-963.

184. Ekapol Umpongsa, K Raisri Umpruyn: “Preparation and evaluation of Diltiazem

Hydrochloride. Diffusion controlled transdermal delivery system”, APPS Pharm Sci

Tech, 2008. 9.

185. Soumya Prakash Rout, K A Choudary, D.M. Kar, Lopamudra Das, Auijeet Jain:

“Plants in traditional Medicinal system – future source of New drugs”, International

Journal of pharmacy & pharmaceutical sciences 2009; 1(1).

186. Kelvin C Garala, Harinath N more, Anil J shinde: 2008 “Development &

characterization of transdermal therapeutics system of tramadol hydrochloride”

Asian J. Pharm 2008; 2; 265-269.

187. Gupta J.R.D., Irchhaiaya R., “Formulation and evaluation of matrix type

transdermal patches of Glibenclamide”. Int J of Pharm Sci and Drug Res

(IJPSDR) 2009; 1(1):46-50

188. Aurapa Sakulpanich, Wandee Gritsanapan: “Determination of Anthraquinone

Glycoside content in Cassia fistula leaf extracts for Alternative source of Laxative

drug”, International journal of Biomedical & Pharmaceutical Sciences 2009 3 (1), 42-

45.

189. Rakesh P. “Formulation and Evaluation of Transdermal Patch of Aceclofenac”.

Int .J .Drug Del. 2009;1: 41-51

190. Garala K. C. Shinde A. J. Shah P. H: “Formulation and in-vitro characterization of

monolithic matrix Transdermal systems using HPMC/Eudragit s 100 polymer

blends”, International journal of pharmacy and pharmaceutical sciences 2009; 1(1):108-

120.

191. Mitragotri Samir, Karande Pankaj: “Enhancement of transdermal drug delivery via

synergistic action of chemicals” Biochimica et Biophysica Acta 1788 (2009) 2362–

2373.

192. Barhate SD, Patel MM, Sharma AS, Nerkar. P: “Formulation and evaluation of

transdermal drug delivery system of Carvedilol”. J Pharm Res. 2009; 2(4): 663 – 665.

193. Sashikant DM, Barhate: “formulation and evaluation of transdermal drug delivery

system of carvedilol”. Journal of Pharmacy Research 2009; 2(4): 663-665.

194. Patel RP, Patel G, Baria A: “formulation and evaluation transdermal patch of

aceclofenac”, Int J Drug Deliv 2009; 1: 41-51.

195. Shiva Kumar. HN, Jamakandi. VG, Mulla JS, Vinay B.L: “Formulation

characterization and evaluation of matrix – type trandermal patches of a model

antihypertensive drug”, Asian J Pharm 2009; 3: 59 – 64.

196. Patel H.J, Patel J.S, Desai B.G, Patel K.D: “Design and evaluation of Amlodipine

besilate transdermal patches containing film former”, Int J Pharm Res Dev 2009; 7:

1-12.

197. Pandit V, Khanum A, Bhaskaran S, Banuv: “formulation and evaluation of

transdermal films for the treatment of overactive bladder”. Int J Pharma Tech Res

2009; 1(3): 799-804.

198. Rao V, Mamatha T, Mukkanti K and Ramesh: “Transdermal drug delivery system

for atomoxetine hydrochloride in vitro and ex vivo evaluation”. Current Trends in

Biotechnology and Pharmacy 2009; 3(2): 188-196.

199. Umesh D shivaare, Vikrant P, Dorlikar, Kishore P, Bhusari, Vijay B, Mathur Bhlku, N

Mirani: “Effect of polymeric composition on pharmaceutical properties of

Carvedilol transdermal film”. International Journal of Pharmaceutical sciences and

Nanotechnology 2009; 2(1).

200. Yellela S.R. Krishnaiah Bukka Rama, Vanambattina Raghumurthy, Kolapalli V.

Ramanamurthy: “Effect of PEG6000 on the In Vitro and In Vivo Transdermal

Permeation of Ondansetron Hydrochloride from EVA1802 Membranes”.

Pharmaceutical Development and Technology, 2009, 14:53–64.

201. Zoroddu, Maria Antonietta and Medici, Serenella and Peana, Massi Miliano, Francesco:

“Metal chelating properties of carvedilol: An antihypertensive drug with anti

oxidant activity” Journal of coordination chemistry 2009; 62(3), P 3828 – 3836.

202. Jai Cao, Lan Hamilton – Ooig, Jing sun , Laurence Howey, John Edwards Rohan Jaya

Singhex Australagian: “Bisoprolo vs. carvedilol a comparison of clinical efficacy &

tolerability in congestive heart failure”, Medical Journal 2009; 1(5): 1- 19.

203. Vinayak D, Kadam, Surendra G, Gattani: “Dissolution enhancement of carvedilol by

using surfactant as a coating material” Asian Journal of pharmaceutical and clinical

research 2009 Sep; 2(3).

204. Ahad Hindustan Abdul, Chitta Suresh Kumar, Anil Kumar.B, Amaranth Reddy.B,

Chandra shekar A, Ravindar. BV, Lakshmi Venkatnath. S: “Development and in vitro

evaluation of Glibenclamide aloe barbadensis miller leaves mucilage controlled

release matrix tablets”. Int J of Pharm Tech Research1998; 2(2):1018-1021.

205. Obata Yasuko, Ashitaka Yuriko, Kikuchi Shingo, Isowa Koichi, Takayama Kozo: “A

statistical approach to the development of a transdermal delivery system for

Ondansetron”, International Journal of Pharmaceutics 399 (2010); 87–93.

206. Suryadevara P.K and Nanjwade B.K: “Formulation and evaluation of antiemetic

patches of Ondensetron hydrochloride”; Dissertation submitted in KLE Belgum,

Karnataka, May 2010.

207. Shankar MS, Kulkarni SV, Sandeep HN, Ranjit Kumar P, Someshwar Rao B, Ashok

Kumar P: “Development and evaluation of Aceclofenac transdermal patches using

hydrophilic and hydrophobic polymers”, Journal of Global Pharma Technology,

2010; 2(4):102-109.

208. Madishetti S.K, Palem C.R, Gannu R, Thatipamula R.P, Panakanti P.K and Yamsani

M.R: “Development of Domperidone bilayered matrix type transdermal patches:

Physicochemical, in vitro and ex vivo Characterization”, DARU 2010 Volume 18(3)

221-229.

209. Saraswathi R, Krishnan. PN, Dilip. C, Shabir Ali TK: “Formulation & Evaluation of

Transdermal patches of Curcumin”, Scholars Research Library. Der Pharmacia letter,

2010, 2(5): 117-126.

210. Meenakshi Bharkatiya, Rajesh Kumar Nema and Maheep Bhatnagar: “Formulation &

Evaluation of Metoprolol tartarate entrapped niosomes”, Int. J Chem Sci 2010; 8(4):

2055-2065.

211. Hima Bindu T.V.L, Vidyavathi M.1*, Kavitha K, Sastry T.P, Suresh Kumar R.V.

“Preparation and Evaluation of Chitosan-Gelatin Composite Films for Wound

Healing Activity Trends Biomater”. Artif. Organs, 2010; 24(3): 123-130.

212. Ainbinder. D, Paoleno. D, Fresta. M, Touitou. E, “Drug delivery applications with

ethosomes”: J Biomed Nano Technol 2010 Oct; 6(5): 558 – 568.

213. Zhou. Y, Wei. YH, Zhang G.Q, WU XA “Synergistic penetration of ethosomes and

lipophilic prodrug on the transdermal delivery of acyclovir”, Arch Pharma Res, 2010

Apr; 33(4): 567 -574.

214. Shumilov. M, Touitou. E “Buspirone transdermal administration for menopausal

syndromes in vitro and in animal model studies”, Int J Pharm 2010 Mar 15; 387 (1-

2): 26 – 33.

215. Sanjay Dey, Ananya Macgope: “Preparation of carvedilol transdermal patch and

the effect of propylene glycol on permeation” International Journal of pharmacy and

pharmaceutical sciences and nanotechnology, Dec 2013; 6 (3).

216. Shirsand, S.B, G.V Wadageri, S.A Raju and Gopikrishna Kolli: “Formulation and in

vivo Evaluation of mucoadhesive Buccal tablets of Carvedilol”, International Journal

of Pharmaceutical Sciences and Nanotechnology, Dec 2013 ; 6 (3).

217. Theivarasu C, S. MYLSAMY and N. SIVAKUMAR: “Removal of Malachite Green

from Aqueous Solution by Activated Carbon Developed from Cocoa (Theobroma

cacao) Shell: Kinetic and Equilibrium Studies” ORIENTAL JOURNAL OF

CHEMISTRY 2011; 27 (3): 1083-1091.

218. Vivek Kumar V Vasu Naik, Y Narsimha Rao, G. Nagarjuna Reddy and KPR

Chowdary. “Formulation and Evaluation of Modified Release carvedilol tablets” An

international Journal of Advances in Pharmaceutical Sciences, 2010; 1(1); 83-87.

219. Vijayakumar M.R., Abdul Hasan Sathali a, Arun K:“formulation and

evaluation of diclofanac potassium ethosomes International Journal of Pharmacy

and Pharmaceutical Sciences Vol 2, Issue 4, 2010 ISSN- 0975-1491

220. Vivek Dave1, Dhirendra Kumar1, Shaila Lewis1, Sarvesh Paliwal: “Ethosome for

Enhanced Transdermal Drug Delivery of Aceclofenac”. International Journal of

Drug Delivery 2010; 2: 81-92.

221. Ashoniya Sheer, Dr.Meenakshi Chauhan: “Ethosomes as vesicular carrier for

enhanced Transdermal delivery of Ketoconazole - Formulation and Evaluation”.

IJPI’s Journal of Pharmaceutics and Cosmetology 2011; 1: 3.

222. Xingyan Liu1 hong Liu1 Jianqiang Liu2 Zhiwei he1 congcong Ding1 guoliang huang1

Weihua Zhou3 Leshan Zhou3 “Preparation of a ligustrazine ethosome patch and its

evaluation in vitro and in vivo”, International Journal of Nanomedicine 2011:6 241–

247.

223. R.Vijaya*, D.Deepa, T.Senbagha priya and K.Ruckmani “The Development And

Evaluation Of Transdermal Films International Journal Of Pharmacy&Technology

March-2011 | Vol. 3 | Issue No.1 | 1920-1933

224. Snigdha Bharadwaj, Vipin Kumar Garg, P.K. Sharma, Mayank Bansal, Nitin Kumar.

“Recent advancement in Transdermal drug delivery system”, Int J of Pharma

Professional’s Research Jan 2011. 2 (1).

225. Kalyani a.l.t, Ramya sravani k. M, babu rao ch. “formulation and evaluation of

transdermal patches and to study permeation enhancement effect using natural

enhancer”. International Journal of Pharmacy and Pharmaceutical Sciences,2012; 4

(1):

226. Bhavna Yadav, Benika Sharma, Kamal Saroha: “Transdermal Patch: “A discrete

dosage form” Int J of Current Pharmaceutical Research 2011; 3, (3): 98-108.

227. Nirav. S Sheth, Rajan. B, Mistry: “Formulation & Evaluation of Transdermal

Patches & to study permeation enhancement effect of Eugenol”, Journal of Applied

Pharmaceutical Science 2011; 01 (03); 96-101.

228. Nilani P.*, Pranavi A., Duraisamy B., Damodaran P., Subhashini V. and Elango K.

“Formulation and evaluation of wound healing dermal patch”. African Journal of

Pharmacy and Pharmacology, 2011; 5(9): 1252-1257.

229. Jayasutha. J, Monic Josephine Nithila: “Evaluation of wound healing activity of

Ethanolic extract of Aristolochia bracteata & Cassia tora on Wistar Albino rats”,

Int. J. of Pharm Tech Research CODEN (USA) July-Sept 2011; 3: PP 1547-1550, July-

Sept 2011.

230. Tashiro Y, Sami M, Shichibe S Kato Y, Hayako E, Hon: “Effect of lipophilicity on in

vivo iontophoretic delivery II beta blockers”. Biopharma Bull 2011; 24: 671-677.

231. Tijani Adeniyi Yahaya, Salawu Oluwakanyinsola Adeola, Ubobo Unyime Emma

“Neuro protective effect of carvedilol , an adrenergic antagonist against

scopolamine – induced cognitive impairment in mice”, Journal of Applied

Pharmaceutical Science 3(8): P 532 – 536.

232. Swatantra KU, Mishra, Rakesh Varma and Sandeep Singh Parihar: “Formulation and

evaluation of mouth dissolving tablets of carvedilol”, International Journal of Pharma

and bio science, 2011 March; 2 (1).

233. Ritesh shah, Sachin Patel, Hetal Patel, Sonia Pandey, Shailesh Shah, Dinesh shah:

“Development and validation of dissolution method for carvedilol compression -

coated tablets”, Brazilian Journal of pharmaceutical sciences 2011: 4(2).

234. Ritesh shah, Sachin Patel, Hetal Patel, Sonia Pandey, Shailesh shah, Dinesh shah.

“Development and validation of dissolution method for carvedilol compression –

coated tablets”, Braz J Pharm Sci 2011; 47 (4).

235. Self .T, Rogers M.L, Mancell. J, Soberman J. E: “Carvedilol therapy after cocaine

induced myocardial infarction in patients with asthma”, AMJ Med Sci 2011 Jul; 342

(1): 56 - 61.

236. Xing X.J, Yang .L, you. Y, Zhong B.Y, Song Q.H, Deng. J, Hao. E: “Study of the

biological function and penetration pathways of the mouse epidermal growth factor

ethosomal delivery system”, Exp Dermatol. 2011 Nov; 20(11): 945 – 947.

237. Manish K. Chourasia, Liteng Kang, and Sui Yung Chan: “Nano sized ethosomes

bearing Ketoprofen for improved transdermal delivery Results in Pharma sciences”

2011; 1(1): P 60-67.

238. R.Vijaya, S.Sureshkumar, S.Umamaheswari, M.Prakash, T. Senbagapriya and

A.Umamaheswari “Preparation Of Amitriptyline Hydrochloride Films Using

Eudragit Rl 100 And Hydroxy Propyl Methyl Cellulose Polymers And Their In-

Vitro Evaluation For Effective Transdermal Delivery” international journal of life

science and pharma research Vol 2/Issue 2/Apr-Jun 2012 ISSN 2250-0480.

239. Tarun Parashar, Soniya, Roopesh Sachan, Vishal Singh, Gaurav Singh,

SatyanandTyagi, Chirag Patel, Anil Gupta. “Ethosomes: A Recent Vesicle Of

Transdermal Drug Delivery System”. International Journal of Research and

Development in Pharmacy and Life Sciences February - March, 2013; 2(2), pp 285-292.

240. Sheba Rani Nakka David, Mah Si Hui1, Chong Fui Pin1, Foo Yun Ci1, Rajan

Rajabalaya1 “Formulation and in vitro evaluation of ethosomes as vesicular carrier

for enhanced topical delivery of isotretinoin” International Journal of Drug Delivery

5 (2013) 28-34.

241. Bhosale S.S, Avachat M.M: “Design & development of ethosomal transdermal drug

delivery system of Valsartan with preclinical assessment in Wistar albino rats”, Int J

liposomes Res, 2013 June; 23 (2): 119 -125.

242. Bodade S.S, Shaikh K.S, Kamble M.S, Chaudari P.D: “A study on ethosomes as made

for transdermal delivery of an antidiabetic drug”, Drug Deliv 2013; 20(1): 40 - 46.

243. Kodani. E, Matsumoto. S, Igawa. O . Kusama. Y: “Atarashilt effect of carvedilol on

reduction in heart rate in patients with chronic atrial fibrillation”, J Clin Med Res,

2013 Dec; 5(6): 451 – 459.

244. Moayad Hossaini sadr and Hatezeh Nabipour: “Synthesis and identification of

carvedilol nano particles by ultrasound method”, Journal of Nano structure in

chemistry 2013; 3: 26.

245. Thomas Reiberger, Gregor Ulbrich, Arnulf ferlitsch, Berit Anna payer, Philipp schwabl,

Markus peck – Radosavuevic: “Carvedilol for primary prophylaxis of variceal

bleeding in cirrhotic patients with haemodynamic non – response to propranolol” ,

Gut 2013 11-01.

246. Vaishali Aggarwal, Ratna Kumar, Rjaiv Sharma, Yogendra singh, Uday Veer Singh

Feotia: “Formulation and optimization of polyethyleneimine treated calcium

alginate beads of carvedilol phosphate using experimental design technique”. Int J

Pharm biomed Res 2013; 4(4): 215-220.

247. Sandya P, Shadab Khanam, Divya Bhatnagar, K.S.K Rao Patanik, C.V.S

Subramanyam: “Formulation and Evaluation of liquid solid compacts of carvedilol”

Journal of pharmacy and Biological Sciences 2013; 6(5).

248. Bhale shweta, Bhandari Govind, Pal Pradeep, Mahajan S.C: “Formulation and

evaluation of ethosomes for transdermal drug delivery system of etodolac” Am J

Pharm Tech Res 2013; 3(5).

249. Ahad. A, Al- Mohizea A.M, Al Jenoobi E.I, Aqil. M: “Transdermal delivery of

angiotensin – II receptor blockers (ARBS) Angiotensin Converting Enzyme

inhibitors (ACEIS) and others for management of hypertension”, Drug Deliv 2014;

28 1-2.

250. Dahl LK: “Salt and hypertension”. Am. J. Clin. Nutr. 1972; 25: 231-244.

251. Ogihara.T, Asano.T, Ando.K, Sakoda.H, Anai.M, Shojima.N, Ono.H, Onishi.Y,

Fujishiro.M, Abe.M, Fukushima.Y, Kikuchi.M, and Fujita.T: “High-salt diet enhances

insulin signalling and induces insulin resistance in Dahl salt-sensitive rats”.

Hypertension.2002; 40:83-89.

252. Tian.N, Thrasher.KD, Gundy.PD, Hughson.MD, Manning.RD, Jr: “Antioxidant

treatment prevents renal damage and dysfunction and reduces arterial pressure in

salt-sensitive hypertension”. Hypertension 2005; 45: 934-939.

253. Cowley.AW, Jr., Stoll.M, Greene.AS, Kaldunski.ML, Roman.RJ, Tonellato.PJ,

Schork.NJ, Dumas.P, and Jacob.HJ: “Genetically defined risk of salt sensitivity in an

intercross of Brown Norway and Dahl S rats”. Physiol Genomics. 20002:107-115.

254. Dahl. LK, Knudsen. KD, Heine. MA, Leitl GJ: “Effects of chronic excess salt

ingestion. Modification of experimental hypertension in the rat by variations in the

diet”. Circulation Research. 1968; 22:11-18.

255. Rapp. JP, Dene. H: “Development and characteristics of inbred strains of Dahl salt-

sensitive and salt-resistant rats”. Hypertension 1985; 7: 340-349.

256. Rapp JP: “Dahl salt-susceptible and salt-resistant rats: A review”. Hypertension

1982; 4: 753-763.

257. Inoko. M, Kihara. Y, Morii. I, Fujiware. H, Sasayama. S: “Transition from

compensatory hypertrophy to dilated failing left ventricles in Dahl salt-sensitive

rats”. Am. J. Physiol. 1994; 267 (Heart Circ. Phsyiol. 36): H2471-H2482.

258. Okamoto K, Aoki K: “Development of a strain of spontaneously hypertensive rats”.

Jap Circ J 1963; 27: 282-293.

259. Ferrone. R, Walsh. G, Tsuchiya. M, Frohlich. E: “Comparison of hemodynamics in

conscious spontaneous and renal hypertensive rats”. Am. J. Physiol. 1979; 236(3):

H403-H408.

260. Aoki. K, Yamori. Y, Ooshima. A, Okamotoa. K: “Effects of high or low sodium

intake in spontaneously hypertensive rats”. Jap Circ J1972; 36: 539-545.

261. Chyrsant. SG, Walsh. GM, Kem. DC, Frohlich ED: “Hemodynamic and metabolic

evidence of salt sensitivity in spontaneously hypertensive rats”. Kidney International.

1979; 15: 33-27.

262. Yu.Q, Larson.DF, Slayback.D, Lundeen.TF, Baxter.JH, Watson.RR:

“Characterization of high-salt and high-fat diets on cardiac and vascular function in

mice”. Cardiovasc.Toxicol. 2004; 4:37-46.

263. Cvetkovic. B, Sigmund. CD: “Understanding hypertension through genetic

manipulation in mice”. Kidney International 2000; 57: 863-74.

264. Mattson.DL, Kunert.MP, Kaldunski.ML, Greene.AS, Roman.RJ, Jacob.HJ,

Cowley.AW, Jr: “Influence of diet and genetics on hypertension and renal disease in

Dahl salt-sensitive rats”. Physiol Genomics 2004; 16:194-203.

265. Nevala. R, Vaskonen. T, Vehniainen. J, Korpela. R, Vapaatalo. H: “Soy based diet

attenuates the development of hypertension when compared to casein based diet in

spontaneously hypertensive rat”. Life Sci 2000; 66(2): 115-124.

266. Cho. TM, Peng. N, Clark. JT, Novak. L, Roysommuti. S, Prasain. J, Wyss. JM:

“Genistein Attenuates the Hypertensive Effects of Dietary NaCl in Hypertensive

Male Rats”. Endocrinology. 2007; 148(11):5396-5402.

267. Jensen. MN, Ritskes-Hoitinga. M: “How isoflavone. Levels in common rodent diets

can interfere with the value of animals’ models and with the experimental results”.

Laboratory Animals 2007; 41: 1-18.

268. Melancon. S, Bachelard. H, Badeau. M, Bourgoin. F, Pitre. M, Lariviere. R, Nadeau A:

“Effects of high-sucrose feeding on insulin resistance and hemodynamic responses

to insulin in spontaneously hypertensive rats”. Am. J. Physiol. Heart Circ Physiol

2006; 290: H2571-H2581.

269. Pitre. M, Nadeau. A, Bachelard. H: “Insulin sensitivity and hemodynamic responses

to insulin in Wistar-Kyoto and spontaneously hypertensive rats”. Am. J. Physiol.

1996; 271 (Endocrinol. Metab. 34): E658-E668.

270. Oron-Herman. M, Kamari. Y, Grossman. E, Yeger. G, Peleg. E, Shabtay. Z, Shamiss.

A, Sharabi. Y: Metabolic Syndrome: “Comparison of the two commonly used animals

models:. Am. J. Hypertens. 2008; 21: 1018-1022.

271. Sanchez-Lozada.LG, Tapia.E, Jimenez.A, Bautista.P, Cristobal.M, Nepomuceno.T,

Soto.V, Avila-Casad.C, Nakagawa.T, Johnson.RJ, Herrera-Acost.J, and Franco.M:

“Fructose-induced metabolic syndrome is associated with glomerular hypertension

and renal microvascular damage in rats”. Am J Physiol Renal Physiol 2007; 292:

F423-F429.

272. Vasudevan.H, Xiang.H, McNeill.JH: “Differential regulation of insulin resistance

and hypertension by sex hormones in fructose-fed male rats”. Am J Physiol Heart

Circ Physiol 2005; 289:H1335-H1342.

273. Sharma. N, Okere. IC, Duda. MK, Johnson. J, Yuan. CL, Chandler. MP, Ernsberger. P,

Hoit. BD, Stanley. WC. “High fructose diet increases mortality in hypertensive rats

compared to a complex carbohydrate or high fat diet”. Am J Hypertens. 2007; 20:

403-409.

274. Sharma. N, Okere. IC, Barrows. BR, Lei. B, Duda. MK, Yuan. CL, Previs. SF, Sharov.

VG, Azimzadeh. AM, Ernsberger. P, Hoit. BD, Sabbah. H, Stanley. WC. “High-sugar

diets increase cardiac dysfunction and mortality in hypertension compared to low-

carbohydrate or high-starch diets”. J Hypertens. 2008; 26: 1402-1410.

275. Hwang. IS, Ho. H, Hoffman. BB, Reaven. GM: “Fructose-Induced Insulin Resistance

and Hypertension in Rats”. Hypertension.1987; 10: 512-516.

276. Dobrian.AD, Davies.MJ, Prewitt.RL, Lauterio.TJ: “Development of hypertension in a

rat model of diet-induced obesity”. Hypertension.2000; 35:1009-1015.

277. Dobrian.AD, Schriver. SD, Lynch. T, Prewitt.RL: “Effect of salt on hypertension and

oxidative stress in a rat model of diet-induced obesity”. Am J Physiol Renal Physiol.

2003; 285: F619-F628.

278. Yamakawa. T, Tanaka. S, Tamura. K, Isoda. F, Ukawa. K, Yamakura. Y, Takanashi. Y,

Kiuchi. Y, Umemura. S, Ishii. M, Sekihara. H: “Wistar fatty rat is obese and

spontaneously hypertensive”. Hypertension. 1995; 25: 146-150.

279. Dahl. LK, Letil. G, Heine. M: “Influence of dietary potassium and

sodium/potassium molar ratios on the development of salt hypertension”. J Exp

Med.1972; 136: 318-330.

280. Kopilas.MA, Dang.LNT, Anderson. HDI: “Effect of dietary chromium on resistance

artery function and nitric oxide signalling in the sucrose-fed spontaneously

hypertensive rat”. J Vasc Res. 2007; 44:110-118.

281. Vasdev.S, Gill.V, Parai.S, Gadag.V: “Dietary vitamin e supplementation attenuates

hypertension in Dahl salt-sensitive rats”. J Cardiovasc Pharmacol Ther. 2005; 10:103-

111.

282. Noguchi.T, Ikeda.K, Sasaki.Y, Yamamoto.J, Yamori.Y: “Effects of vitamin e and

sesamin on hypertension and cerebral thrombogenesis in stroke-prone

spontaneously hypertensive Rats”. Clin Exp Pharmacol Physiol. 2004; 31 (Suppl 2):

S24-S26.

283. Plehm. R, Barbosa. ME, Bader. M. “Animal models for hypertension/blood pressure

Recording”. Methods Mol Med. 2006; 129:115–26.

284. Kramer. K, Remie. R. “Measuring blood pressure in small laboratory animals”.

Methods Mol Med. 2005; 108:51–62.

285. Van Vliet. BN, Chafe. LL, Antic. V, Schnyder-Candrian. S, Montani. JP. “Direct and

indirect methods used to study arterial blood pressure”. J Pharmacol Toxicol

Methods. 2000; 44:361–73.

286. Zorniak. M, Mitrega. K, Bialka. S, Porc. M, Krzeminski. TF. “Comparison of

thiopental, urethane, and pentobarbital in the study of experimental cardiology in

rats in vivo”. J Cardiovasc Pharmacol. 2010; 56:38–44.

287. “CPCSEA guidelines for laboratory animals”. Indian J Pharmacol. 2003; 35:257–

74.

288. Schlager. G. “Selection for blood pressure levels in mice. Genetics. 1974; 76:537-549.

289. Steinhelper. ME, Cochrane. KL, Field. LJ. “Hypotension in transgenic mice

expressing atrial natriuretic factor fusion genes”. Hypertension. 1990; 16:301-307.

290. Jeunemaitre. X, Soubrier. F, Kotelevtsev. YV, Lifton. RP, Williams. CS, Charru. A,

Hunt. SC, Hopkins. PN, Williams. RR, Lalouel. JM, Corvol. P. “Molecular basis of

human hypertension: role of angiotensinogen”. Cell. 1992; 71:169-180.

291. Smithies. O, Kim. HS. “Targeted gene duplication and disruption for analyzing

quantitative genetic traits in mice”. Proc Natl Acad Sci U S A. 1994; 91:3612-3615.

292. Milano. CA, Allen. LF, Rockman. HA, Dolber. PC, McMinn. TR, Chien. KR, Johnson.

TD, Bond. RA, Lefkowitz. RJ. “Enhanced myocardial function in transgenic mice over

expressing the β2-adrenergic receptor”. Science. 1994; 264:582-586.

293. Kurihara. Y, Kurihara. H, Suzuki. H, Kodama. T, Maemura. K, Nagai. R, Oda. H,

Kuwaki. T, Cao. WH, Kamada. N, Jishage. K, Ouchi. Y, Azuma. S, Toyoda. Y, Ishikawa.

T, Kumada. M, Yazaki. Y. “Elevated blood pressure and craniofacial abnormalities in

mice deficient in endothelin-1”. Nature. 1994; 368:703-710.

294. Sigmund. CD, Jones. CA, Kane. CM, Wu. C, Lang. JA, Gross. KW. “Regulated tissue-

and cell-specific expression of the human renin gene in transgenic mice”. Circ Res.

1992; 70:1070-1079.

295. Kimura. S, Mullins. JJ, Bunnemann. B, Metzger. R, Hilgenfeldt. U, Zimmermann. F,

Jacob. H, Fuxe. K, Ganten. D, Kaling. M. “High blood pressure in transgenic mice

carrying the rat angiotensinogen gene”. EMBO J. 1992; 11:821-827.

296. Mockrin. SC, Dzau. VJ, Gross. KW, Horan. MJ. “Transgenic animals: new approaches

to hypertension research. Hypertension. 1991; 17:394-399.

297. Jacob. HJ, Sigmund. CD, Shockley. TR, Gross. KW, Dzau. VJ. “Renin promoter SV40

T-antigen transgenic mouse: a model of primary renal vascular hyperplasia”.

Hypertension. 1991; 17:1167-1172.

298. Ohkubo. H, Kawakami. H, Kakehi. Y, Takumi. T, Arai. H, Yokota. Y, Iwai. M, Tanabe.

Y, Masu. M, Hata. J, Iwao. H, Okamoto. H, Yokoyama. M, Nomura. T, Katsuki. M,

Nakanishi. S. “Generation of transgenic mice with elevated blood pressure by

introduction of the rat renin and angiotensinogen genes”. Proc Natl Acad Sci U S A.

1990; 87:5153-5157.

299. Schlager. G. “Genetic hypertension in different strains of mice”. In: de Jong W, ed.

Handbook of Hypertension, Volume 4: Experimental and Genetic Models of

Hypertension. New York, NY: Elsevier Science Publishers; 1984:193-199.

300. Svendsen. UG. “Spontaneous hypertension and hypertensive vascular disease in the

NZB strain of mice”. Acta Pathol Microbiol Scand A. 1977; 85:548-554.

301. Weibust. RS, Schlager. G. “A genetic study of blood pressure, hematocrit and

plasma cholesterol in aged mice. Life Sci. 1968; 7(part II):1111-1119.

302. Schlager G. “Systolic blood pressure in eight inbred strains of mice”. Nature. 1966;

212:519-520.

303. Buñag. RD. “Facts and fallacies about measuring blood pressure in rats”. Clin Exp

Hypertens A. 1983; 5:1659-1681.

304. Sponer. G, Müller-Beckmann. B, Martin. U. “Blood pressure recording in rats:

pitfalls and problems”. In: Gretz. N, Strauch. M, eds. Experimental and Genetic Rat

Models of Chronic Renal Failure. Basel, Switzerland: Karger; 1993:319-330.

305. Pfeffer. JM, Pfeffer. MA, Frohlich. ED. “Validity of an indirect tail-cuff method for

determining systolic arterial pressure in unanesthetized normotensive and

spontaneously hypertensive rats”. J Lab Clin Med. 1971; 78:957-962.

306. Ikeda. K, Nara. Y, Yamori. Y. “Indirect systolic and mean blood pressure

determination by a new tail cuff method in spontaneously hypertensive rats”. Lab

Anim. 1991; 25:26-29.

307. Yen. TT, Pearson. DV, Powell. CE, Kirschner. GL. “Thermal stress elevates the systolic

blood pressure of spontaneously hypertensive rats”. Life Sci. 1978; 22:359-362.

308. Ferrari. AU, Daffonchio. A, Albergati. F, Bertoli. P, Mancia. G. “Intra-arterial

pressure alterations during tail-cuff blood pressure measurements in normotensive and

hypertensive rats”. J Hypertens. 1990; 8:909-911.

309. Kurtz. TW, St Lezin. EM. “Gene mapping in experimental hypertension”. J Am Soc

Nephrol. 1992; 3:28-34.

310. Chiueh. CC, Kopin. IJ. “Hyperresponsivity of spontaneously hypertensive rat to

indirect measurement of blood pressure”. Am J Physiol. 1978; 234:H690-H695.

311. Ferrari. AU, Daffonchio. A, Albergati. F, Mancia. G. “Limitations of the tail-cuff

method for measuring blood pressure in rats”. J Hypertens. 1986; 4(suppl 5):S179-

S181.

312. Byrom. FB, Wilson. C. “A plethysmographic method for measuring systolic blood

pressure in the intact rat”. J Physiol (Lond). 1938; 93:301-304.

313. Zhang. SH, Reddick. RL, Piedrahita. JA, Maeda. N. “Spontaneous

hypercholesterolemia and arterial lesions in mice are lacking apolipoprotein E”.

Science. 1992; 258:468-471.

314. Fisher. RA. “Statistical Methods for Research Workers”. Darien, Conn: Hafner

Publishing Co; 1973:211.

315. Statistical methods. In: Diem K, ed. Documenta Geigy. Scientific Tables. Ardsley, NY:

Geigy Pharmaceuticals; 1962:178.