Reduced viral reservoirs and sustained virologic control following early cART in HIV-infected youth
-
Upload
zeena-nackerdien -
Category
Health & Medicine
-
view
77 -
download
2
description
Transcript of Reduced viral reservoirs and sustained virologic control following early cART in HIV-infected youth
Reduced viral reservoirs in HIV-infected youth following early cART: A long-term follow-up report by Luzuriaga et al.Zeena Nackerdien
Effects of Sustained Virologic Control in Early-Treated HIV-1- Infected Children
cART, combination anti-retroviral therapy; rep., replication1 Luzuriaga K, Tabak B, Garber M, Chen YH, et al. Reduced HIV Reservoirs After Early Treatment HIV-1 Proviral Reservoirs Decay Continously Under Sustained Virologic Control in Early-Treated HIV-1- Infected Children. The Journal of Infectious Diseases. 2014 (e-pub).
Long-term follow-up (up to 18 years)
4 infected youth who received ART during established infection
(6-14.7 y) also included
cART started between 2 & 11 weeks of age
Perinatally infected youth (aged 14-18)
CONCLUSIONSEarly, effective
cART from infancy significantly limits
circulating levels of proviral and rep.-
competent HIV-1 & promotes
continuous decay of viral
reservoirs