Reduce the risk of Travellers’ Diarrhoea - Occasional Diarrhea...diarrhea following an oral...
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travelan.com Reduce the risk of Travellers’ Diarrhoea Travelan® is an orally administered passive immunotherapy that prophylactically reduces the likelihood of contracting Travellers’ Diarrhoea. The active ingredient in Travelan® is hyperimmune bovine colostrum enriched with Anti-E. coli antibodies. When taken with meals, Travelan® binds to Diarrhoea- causing bacteria and prevents colonisation and the pathology associated with Travellers’ Diarrhoea. ALWAYS READ THE LABEL. CONTAINS COW’S MILK PROTEINS AND LACTOSE. IF SYMPTOMS PERSIST CONSULT YOUR HEALTHCARE PRACTITIONER.
Transcript of Reduce the risk of Travellers’ Diarrhoea - Occasional Diarrhea...diarrhea following an oral...
travelan.com
Reduce the risk of Travellers’ DiarrhoeaTravelan® is an orally administered passive immunotherapy that prophylactically reduces the likelihood of contracting Travellers’ Diarrhoea. The active ingredient in Travelan® is hyperimmune bovine colostrum enriched with Anti-E. coli antibodies. When taken with meals, Travelan® binds to Diarrhoea-causing bacteria and prevents colonisation and the pathology associated with Travellers’ Diarrhoea.
ALWAYS READ THE LABEL. CONTAINS COW’S MILK PROTEINS AND LACTOSE. IF SYMPTOMS PERSIST CONSULT YOUR HEALTHCARE PRACTITIONER.
REFERENCES1: Steffan, Epidemiology of travellers’ diarrhea, Journal of Travel Medicine. 2: Jiang & DuPong, Etiology of travellers’ diarrhea, Journal of Travel Medicine.
Low risk Intermediate risk High risk
Mode of ActionThe antibodies in Travelan® bind to E. coli and other Travellers’ Diarrhoea causing bacteria in the gastrointestinal tract preventing them from attaching to the intestinal wall and thereby neutralizing their ability to cause Diarrhoea and its associated symptoms.
Without Travelan®Bacteria attach to the gut wall and infect
With Travelan®Bacteria neutralised by Travelan® antibodies
Don’t let diarrhoea ruin your patients’ tripTravellers’ diarrhoea continues to be the most frequent health problem in Travellers1 and the most common causes include the bacteria, Enterotoxigenic Escherichia coli (ETEC)2.
Travelan® can be used whenever there is a concern about the sanitation of food or water at holiday or business destinations.
Popular destinations with a high risk of Travellers’ Diarrhoea include:
• Thailand
• Bali/Indonesia
• India
• China
• Vietnam, Cambodia, Laos
• Mexico
• South America
• Africa
• Egypt
• Middle East
Global Risk of Travellers’ Diarrhoea
In vitro study 2017*
The US Department of Defence tested Travelan® against 180 different samples of bacteria collected from personnel with travellers’ diarrhoea over a 20 year period.
Travelan® reacted with every single one of the 180 bacteria samples , including different strains of:
• Campylobacter• Enterotoxigenic Escherichia coli (ETEC)• Shigella
In vivo study 2018*
The therapeutic potential of Travelan® against Shigella was confirmed in preclinical shigellosis challenge studies in non-human primates.
Travelan® prevented clinical Shigellosis (bacillary dysentery) in 75% of primates treated with Travelan® compared to placebo.
Travelan® is clinically proven to reduce the risk of Travellers’ Diarrhoea by up to 90%3
CHALLENGE STUDY OVERVIEW
Scandinavian Journal of Gastroenterology, 2011.Otto, Najnigier, Stelmasiak & Robins-Browne
Trial demonstrated up to 90.9% protection against infection with ETEC (p <0.001) with no side effects reported.
Reduction in symptoms of gastrointestinal disorders such as abdominal cramps and stomach pain (p<0.05)
US DEPARTMENT OF DEFENCE RESEARCHWALTER REED ARMY INSTITUTE OF RESEARCH (WRAIR)
Further readingTravelan® demonstrates cross reactivity to Shigella and Salmonella: Sears et al Clinical and Vaccine Immunology doi:10.1128/CVI.00186-16
Two separate randomized, double-blind, placebo-controlled trials involving 90 healthy adult volunteers were performed to investigate the ability of different tablet formulations to protect against diarrhea following an oral challenge with an O78 ETEC strain.
3: Otto et al, Scandinavian Journal of Gastroenterology. Volume 46, Numbers 7-8, July 2011. pp. 862-868(7). *Draft manuscripts in preparation for submission to Scientific Journals.
Unpacking Travelan®Available
• OTC at Australian pharmacies in a 30 caplet box.
Directions for use
• Take one to two caplets before each meal, starting 48 hours before travel. Additional caplets may be taken when increased protection is required.
Active ingredient
• The active ingredient in Travelan® is hyperimmune bovine colostrum enriched with Anti-E. coli antibodies. Travelan® is gluten free.
• Travelan® is anti-microbial, not an anti-biotic. It does not interfere with normal flora in the gastrointestinal tract unlike broad spectrum antibiotics.
Immuron Limited, Building 10, 25-37 Chapman Street, Blackburn North, VIC 3130
Immuron Ltd (ASX:IMC) (NASDAQ:IMRN) is a microbiome company focused on developing and commercialising oral immunotherapeutics for the treatment of many gut mediated diseases. Immuron has a unique and safe technology platform that enables a shorter development therapeutic cycle.
ALWAYS READ THE LABEL. CONTAINS COW’S MILK PROTEINS AND LACTOSE. IF SYMPTOMS PERSIST CONSULT YOUR HEALTHCARE PRACTITIONER.
travelan.com Travelan® is a registered trademark of Immuron Ltd © 2019
Request patient hand-outsTo request patient hand outs, email: [email protected]
Simply provide your name, address and quantity of brochures required.
Reduce the risk of Travellers’ Diarrhoea with TRAVELAN®Make your holiday memorable for all the right reasons.
travelan.com
Reduce the risk of Travellers’ Diarrhoea with TRAVELAN®Make your holiday memorable for all the right reasons.
travelan.com
Reduce the risk of Travellers’ Diarrhoea with TRAVELAN®Make your holiday memorable for all the right reasons.
travelan.com
Listen to a podcast interview with Dr. Hailey Weerts from the US Department of Defense about Travelan® technology:
