Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrück 1961 Matthew Meselson and...
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Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrück 1961 Matthew Meselson and Jean Weigle *Homologous Genetic Recombination *Site Specific Recombination *Transposition
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Transcript of Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrück 1961 Matthew Meselson and...
![Page 1: Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrück 1961 Matthew Meselson and Jean Weigle *Homologous Genetic Recombination *Site Specific.](https://reader036.fdocuments.in/reader036/viewer/2022062320/56649d6b5503460f94a49b2f/html5/thumbnails/1.jpg)
Recombination
Early Experiments:
1947 Alfred Hershey and Max Delbrück
1961 Matthew Meselson and Jean Weigle
*Homologous Genetic Recombination
*Site Specific Recombination
*Transposition
![Page 2: Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrück 1961 Matthew Meselson and Jean Weigle *Homologous Genetic Recombination *Site Specific.](https://reader036.fdocuments.in/reader036/viewer/2022062320/56649d6b5503460f94a49b2f/html5/thumbnails/2.jpg)
Homologous Recombination
*Two broad categories (pathways):
![Page 3: Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrück 1961 Matthew Meselson and Jean Weigle *Homologous Genetic Recombination *Site Specific.](https://reader036.fdocuments.in/reader036/viewer/2022062320/56649d6b5503460f94a49b2f/html5/thumbnails/3.jpg)
Homologous Recombination
![Page 4: Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrück 1961 Matthew Meselson and Jean Weigle *Homologous Genetic Recombination *Site Specific.](https://reader036.fdocuments.in/reader036/viewer/2022062320/56649d6b5503460f94a49b2f/html5/thumbnails/4.jpg)
Homologous Recombination
![Page 5: Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrück 1961 Matthew Meselson and Jean Weigle *Homologous Genetic Recombination *Site Specific.](https://reader036.fdocuments.in/reader036/viewer/2022062320/56649d6b5503460f94a49b2f/html5/thumbnails/5.jpg)
RecBCD Pathway
http://www.esrf.eu/news/spotlight/spotlight13dnarepair/spotlight_dna_repair_fig1s
![Page 6: Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrück 1961 Matthew Meselson and Jean Weigle *Homologous Genetic Recombination *Site Specific.](https://reader036.fdocuments.in/reader036/viewer/2022062320/56649d6b5503460f94a49b2f/html5/thumbnails/6.jpg)
RecBCD Pathway
RecA filament
![Page 7: Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrück 1961 Matthew Meselson and Jean Weigle *Homologous Genetic Recombination *Site Specific.](https://reader036.fdocuments.in/reader036/viewer/2022062320/56649d6b5503460f94a49b2f/html5/thumbnails/7.jpg)
RecA at work
![Page 8: Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrück 1961 Matthew Meselson and Jean Weigle *Homologous Genetic Recombination *Site Specific.](https://reader036.fdocuments.in/reader036/viewer/2022062320/56649d6b5503460f94a49b2f/html5/thumbnails/8.jpg)
RuvAB facilitate branch migration
![Page 9: Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrück 1961 Matthew Meselson and Jean Weigle *Homologous Genetic Recombination *Site Specific.](https://reader036.fdocuments.in/reader036/viewer/2022062320/56649d6b5503460f94a49b2f/html5/thumbnails/9.jpg)
RuvAB facilitate branch migration
![Page 10: Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrück 1961 Matthew Meselson and Jean Weigle *Homologous Genetic Recombination *Site Specific.](https://reader036.fdocuments.in/reader036/viewer/2022062320/56649d6b5503460f94a49b2f/html5/thumbnails/10.jpg)
Gene Targeting
in Embryonic Stem Cells
www.nobelprize.org
![Page 11: Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrück 1961 Matthew Meselson and Jean Weigle *Homologous Genetic Recombination *Site Specific.](https://reader036.fdocuments.in/reader036/viewer/2022062320/56649d6b5503460f94a49b2f/html5/thumbnails/11.jpg)
Gene Targeting in Embryonic Stem Cells
www.nobelprize.org
![Page 12: Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrück 1961 Matthew Meselson and Jean Weigle *Homologous Genetic Recombination *Site Specific.](https://reader036.fdocuments.in/reader036/viewer/2022062320/56649d6b5503460f94a49b2f/html5/thumbnails/12.jpg)
www.nobelprize.org