Recent Research Advances in the Use of Oral Appliances for ... -- Rece… · Recent Research...
Transcript of Recent Research Advances in the Use of Oral Appliances for ... -- Rece… · Recent Research...
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Recent Research Advances in the Use
of Oral Appliances for the Treatment
of Sleep Disordered Breathing
by
Alan A. Lowe DMD, PhD, FRCD(C), FACD
AAO 114th Annual Session April 26, 2014
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UBC Dentistry Sleep Apnea Team
Alan A. Lowe Professor
Fernanda Almeida Assistant Professor
Ben Pliska Assistant Professor
Hui Chen Clinical Assistant Professor
Mary Wong Programmer/Data Base Manager
Sandra Harrison Clinical Trials Coordinator
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American Academy of Dental
Sleep Medicine
2510 N Frontage Road,
Darien, Illinois 60561
Phone: (630) 737-9705 Fax: (630) 737-9790
Web Site: www.aadsm.org
The Web site has information about the AADSM, a geographic
listing of members, certification status and Web site links.
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Sleep Disordered Breathing
Snoring Upper Airway Obstructive
Resistance Sleep Apnea
Syndrome
Mild Mild Mild
Moderate Moderate Moderate
Severe Severe Severe
+/- Symptoms ++/- Symptoms ++++/- Symptoms
+/-Health Implications ++/-Health Implications +++++Health Implications
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Definitions Apnea
Cessation of airflow > 10 sec whereby the drop in airflow amplitude is > 90% of the baseline
Hypopnea
Breathing that is shollower or slower than normal
by > 30% for at least 10 seconds
Desaturation
A drop of >4% SpO2. A value below 90% is considered abnormal
Severity is classified by the Apnea Hypopnea Index (AHI)
0-5 events/hr Normal
5-15 Mild
15-30 Moderate
>30 Severe
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Oral Appliances – AASM Practice
Parameters (Sleep, 2006; 29:240-243)
Oral Appliances – AASM Practice
Parameters (Sleep, 2006; 29:240-243)
Diagnostic evaluation required at baseline for all patients
OA to be fitted by a dentist
Indicated for snorers after no behavioral change
Indicated for mild and moderate OSA
Initial trial of CPAP before OA in severe OSA
Follow-up PSG for OSA patients required
Regular medical/dental visits to assess for worsening OSA
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OSA Characteristics OSA Characteristics
Common medical disorder
Characterized by recurrent collapse of the
upper airway at night
Often leads to Nocturnal hypoxia/hypercapnia
Sleep fragmentation
Excessive daytime sleepiness
Cardiovascular disease
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Pathophysiology of OSA Pathophysiology of OSA
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Common Symptoms of OSA Common Symptoms of OSA
Loud Snoring
Witnessed Apneas
Excessive Daytime Sleepiness
Morning Headaches
Poor memory/Clouded intellect
Decreased Sex Drive/Impotence
Irritability
OSA tends to worsen with age and increasing weight.
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Management of
Sleep Disordered Breathing
1) Avoidance of Risk Factors
2) Surgery - Tracheostomy, UPPP, Maxillofacial, Genial Tubercle, Hyoid Sling
3) Nasal Continuous Positive Airway Pressure (nCPAP)
4) Oral Appliances – More than 130 options
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Effect of nCPAP on Upper Airway
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Design Variations of OAs
Preformed vs laboratory constructed
Method of retention
Amount of jaw opening
Flexibility of material
Adjustability both vertically and AP
Freedom of jaw movement
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Mandibular Repositioner
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Herbst
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SnoreGuard
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OrthoSom
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Narval
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SomnoDent
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TAP
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Tongue Retaining Device
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KLEARWAY™ APPLIANCE
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OA Patient Titration Goals
• The patient feels more rested during the day and experiences deep
uninterrupted sleep.
• A resolution of morning headaches has occurred.
• An inability to tolerate any further advancement.
• A change in dream patterns may indicate REM catch up.
• A history from the bed partner (bed side tape recorder) that the
snoring intensity and/or frequency has changed. Usually a Snore
Score of 2 or 3 suggests that the airway is open. However, be
cautious of silent apneics until after the follow up analysis is
completed.
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Titration Aids
Patient or bed partner titration goals
Oximetry at home
Portable monitoring at home
Polysomnogram attended in the laboratory
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TM
TM Quest
TM
Klearway TM
NCE INSPIRAPLEX, SINGLE BLINDED, RANDOMIZED
BA
SE
LIN
E
BA
SE
LIN
E
Random
HOSPITAL PSG
COMPLIANCE
COMPLIANCE
HOSPITAL PSG
CEPHALOMETRY
HOME OXIMETRY
HOME OXIMETRY
Ex/Qu/Epw/Vig/QofL
Ex/Qu/Epw/Vig/QofL
CEPHALOMETRY
CRANIOMAND INDEX
CRANIOMAND INDEX
VIDEOENDOSCOPY
VIDEOENDOSCOPY
6 12 18 24 0 TITRATION AHI<30/>30
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0
25
50
75
100
Snore Guard
Tongue Retaining
Device
48 43
61
80
% S
uccess
AH
I >
30
AH
I 15-3
0
KlearwayTM
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MINIMUM SaO2
70
75
80
85
90
95
CPAP OA
Baseline
Outcome
*p<0.001 *p<0.01
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APNEA + HYPOPNEA INDEX
0
10
20
30
40
50
CPAP OA
Baseline
Outcome
*p<0.001 *p<0.001
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EPWORTH SLEEPINESS SCALE
0
2
4
6
8
10
12
14
16
CPAP OA
Baseline
Outcome
*p<0.001 *p<0.002
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QUALITY OF LIFE
0
1
2
3
4
5
6
7
CPAP OA
Baseline Outcome
*p<0.001 *p<0.001 SAQLI
Total
Score
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Systolic (SBP) & Diastolic (DBP)
20
40
60
80
100
120
140
160
180 1
6:0
0
17
:00
18
:00
19
:00
20
:00
21
:00
22
:00
23
:00
0:0
0
1:0
0
2:0
0
3:0
0
4:0
0
5:0
0
6:0
0
7:0
0
8:0
0
9:0
0
10
:00
11
:00
12
:00
mm
Hg
◆: Pre-SBP. ◆ :Post-SBP, ▲: Pre-DBP, ▲ :Post-DBP
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Mean Covert Compliance with Klearway
6.8 hours with a range of 5.6 to 7.5 hours
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ADVANTAGES
Measures time worn
Measures head posture
Battery life of 2 years
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T Scan II Analyses T Scan II Analyses
Maximum bite force changes even at 2 weeks post OA insertion
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Occlusal Changes After Five Years of OA Use
Favorable Change
Correction of Class ll molar
Correction of Class ll cuspid
Reduced OJ or OB
Reduced palatal impingement
Reduced lower incisor crowding
Unfavorable Change
Edge to edge incisors
Reverse OJ or OB
Vertical open bite
Reduced interarch contacts
Posterior cross bite
No Change
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70 OSA
Patients
Favorable
29 (41.4%)
Unfavorable
31 (44.3%)
Small
13
Intermediate
13
Large
3
Large
8
Intermediate
15
Small
8
Change
60 (85.7%)
No Change
10 (14.3%)
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Skeletal Type and Outcomes
Class I Class II/1 Class II/2 Class III
No Change 12.5% 10% 20% 50%
Favorable 25.0% 90% 80% -
Unfavorable 62.5% - - 50%
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-6.0
-4.0
-2.0
0.0
2.0
4.0
SNAº SNPGº SNMPº TFH
OB MDMH U6S LU6SN
Duration of OA Wear and Amount of Craniofacial
Change
< 6yrs 6-8yrs >8yrs
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Appliance Design Changes
Case 5
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Appliance Design Changes
Case 6
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How long was an OA used in this
next patient?
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Four Years of Profile Lite Nasal Mask
(Respironics)
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Aim
To determine the prevalence and characteristics of dental
and skeletal changes in long-term nCPAP users and to
estimate the factors that affect such changes.
Hypothesis
Long-term use of a nCPAP
machine could directly affect the
maxilla as well as anterior tooth
position.
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SNA SNB
SNPg Convexity ANB
SNU1
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Superimposition on the SN line of a typical OSA subject
at baseline and after 35M of nCPCP wear
____ baseline
……. follow-up
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Breeze SleepGear –
Puritan Bennett
Mirage Swift -
ResMed
NASAL PILLOW ALTERNATIVES
Profile Lite Nasal
Mask- Respironics
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Klearway Effects and
Sleep Disordered Breathing
In Children
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Date Questionnaire Min O2 (%) RDI/hr AHI/hr ODI/hr
Pretreatment 2008/2/29 69 89 8 5 2.5
Posttreatment (with Klearway) 2008/9/20 34 94 2.4 0 0
Posttreatment (without Klearway) 2008/9/30 93 3.2 2.6 1
Portable Monitor (Watch-Pat)
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Klearway
Protocol consistent
Rarely lost
Compliance higher since only sleep time wear
Keeps both jaws closed while sleep
Less chair side adjustment
No transverse expansion adjustments
Retention less compromised in the mixed dentition
Twin block
Protocol various (combined with FEA, HG, etc)
Higher chance to be lost
Compliance lower due to full time wear
No orthopedic effect during sleep if mouth breathing
Longer appointment if adjustment needed
Can adjust to allow transverse expansion
Retention can be compromised in the mixed dentition
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Female DOB: Oct13/2002 Insertion date: Oct28/2011
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Female DOB: Oct13/2002 Follow-up : Apr18/2012 Duration: 6 months (Phase I not finished)
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Female DOB: May18/2001 Insertion: Nov 4/2011
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Female DOB: Oct13/2002 Follow-up : Mar2/2012 Duration: 4 months (Phase I finished)
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Both indicated to treat growing children with retruded mandibles (Angle Class II, Division 1)
Both result in significant mandibular dentoalveolar changes in 17-18M
Klearway exhibits more significant dento-alveolar changes in the same treatment period with less wear
Klearway is not useful for posterior crossbites
Klearway appears to be more retentive in the transitional dentition
Klearway has advantages of a heat sensitive material, good compliance, gradual mandibular advancement, maintenance of mandibular closure during sleep and rapid chair-side adjustment
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Some OSA Guidelines for Orthodontists
Don’t hesitate to refer to adult/pediatric sleep specialists
Avoid treatment without a written referral from a physician
Be cautious in patients with previous orthodontic therapy
Use recognized appliances with RCT research
Both case and appliance selection are very important
Be aware of silent apneics and post titration follow up
Don’t over treat post OA or nCPAP occlusal changes
Not all Class IIs have OSA /not all OSAs are Class II
Be engaged in this rapidly changing and exciting field
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Alan A. Lowe, DMD, PhD, FRCD(C)
Professor and Chair, Division of Orthodontics
Department of Oral Health Sciences
Faculty of Dentistry, The University of British Columbia
2199 Wesbrook Mall, Vancouver, B.C. V6T 1Z3
Phone: (604) 822-3414 Fax: (604) 822-3562
E-mail: [email protected]
http://www.Klearway.com