Recent Advances in the Clinical Applications of Stem Cells
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Transcript of Recent Advances in the Clinical Applications of Stem Cells
Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.
Recent Advances in theRecent Advances in theClinical Applications ofClinical Applications of
Stem CellsStem Cells
Dr. Boenjamin Setiawan, Ph.D.Dr. Boenjamin Setiawan, Ph.D.Chairman Stem Cell and CancerChairman Stem Cell and Cancer
InstituteInstitute
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
NationalNationalInsituteInsitute of of
HealthHealthGuidelinesGuidelines
for Stem Cellfor Stem CellResearchResearch
@ 2006 @ 2006 TereseTereseWinslowWinslow
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Countries colored in brown represent about 3.5 billion people, moreCountries colored in brown represent about 3.5 billion people, morethan half the world's population. All have a permissive or flexiblethan half the world's population. All have a permissive or flexible
policy on human embryonic stem cell research and all have bannedpolicy on human embryonic stem cell research and all have bannedhuman reproductive cloning.human reproductive cloning.
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
World Stem Cell Research CentersWorld Stem Cell Research Centers
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
MengapaMengapa ABG ABG pentingpenting????
1.1. AkademiAkademi adalahadalah sumbersumber SDM SDM terdidikterdidik dandansumbersumber IPTEK IPTEK
2.2. SelamaSelama danadana pemerintahpemerintah utkutk R&D R&D kecilkecil makamakasebaiknyasebaiknya FokusFokus pd IPTEK pd IPTEK TeraplikasiTeraplikasi
3.3. BisnisBisnis adalahadalah tempattempat untukuntuk mengkonversimengkonversiIPTEK IPTEK menjadimenjadi produkproduk praktispraktis yang yang bermanfaatbermanfaatuntukuntuk masyarakatmasyarakat
4.4. Government Government adalahadalah KATALISATOR KATALISATOR untukuntukmenciptakanmenciptakan peraturanperaturan yang yang kondusifkondusif untukuntukINOVASI INOVASI melaluimelalui R&D R&D
5.5. ABG ABG harusharus membentukmembentuk kerjasamakerjasama yang yangterintegrasiterintegrasi secarasecara ““SEAMLESSSEAMLESS””
6.6. BudayaBudaya salingsaling mempersulitmempersulit harusharus diubahdiubahmenjadimenjadi BUDAYA SALING BUDAYA SALINGMEMBANTU=GOTONG ROYONGMEMBANTU=GOTONG ROYONG
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
The Human BodyThe Human Body
Consist of 12 Organ SystemsConsist of 12 Organ Systems Consist of 220 types of TissuesConsist of 220 types of Tissues Consist of 50-100 trillion cellsConsist of 50-100 trillion cells Consist of 100 billion neuronsConsist of 100 billion neurons Consist of 46 chromosomes (22 pairs andConsist of 46 chromosomes (22 pairs and
x and y chromosomes)x and y chromosomes) Consist of 30.000 genesConsist of 30.000 genes Consist of 3,2 billion base pairsConsist of 3,2 billion base pairs
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
50-100 Trillion Cells form the50-100 Trillion Cells form theBuilding Block of the Human BodyBuilding Block of the Human Body
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
DNA, the genetic code is principallyDNA, the genetic code is principallyfound in the Nucleus of each cellfound in the Nucleus of each cell
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Consequently DNA is double stranded thatConsequently DNA is double stranded thatwound round each other in a double helixwound round each other in a double helix
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Definition of stem cells: stem cells are unspecialized cells that have twodefining properties: the ability to differentiate into other cells and the ability toself-regenerate/self-renew
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Stem Cells Vol. 24 No. 12 December 2006, pp. 2669 -2676Stem Cells Vol. 24 No. 12 December 2006, pp. 2669 -2676
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Stem CellsStem Cellsare takenare takenfrom thefrom theInner CellInner CellMass atMass at
thetheblastocystblastocyststage andstage andcultured incultured ina Petri diska Petri disk
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Adult Stem Cells: Bone MarrowAdult Stem Cells: Bone Marrow
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Plasticity of Adult Stem CellsPlasticity of Adult Stem Cells
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Therapeutic cloningTherapeutic cloning
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Stem Cell BankingStem Cell BankingCord Blood bankingCord Blood banking is now becoming popular is now becoming popular
for for autologousautologous as well as for as well as for allogeneicallogeneic donor donorAdult Peripheral BloodAdult Peripheral Blood collection and collection and
cryopreservationcryopreservation can also be used for future can also be used for futurediseasesdiseases
Stem cells can be collectedStem cells can be collected from UCB, from UCB,AdipocytesAdipocytes and Peripheral Blood by and Peripheral Blood by ApheresisApheresis
Stem cells can be Stem cells can be CryopreservedCryopreserved for use in for use inCancers, CAD, Stroke, Diabetes, Burns, SpinalCancers, CAD, Stroke, Diabetes, Burns, SpinalCord injury, Osteoarthritis, RegenerativeCord injury, Osteoarthritis, Regenerativemedicine, etc.medicine, etc.
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Target Diseases for Stem Cell TherapyBlood DiseasesBlood Diseases Bone marrow transplants (BMT) are a well known clinicalBone marrow transplants (BMT) are a well known clinical
application of application of hematopoietichematopoietic stem cell (HSC) therapy stem cell (HSC) therapy HSCsHSCs can regenerate all of the different cell types in blood can regenerate all of the different cell types in blood BMT is used for the treatment of blood cancers like leukemiaBMT is used for the treatment of blood cancers like leukemia
and lymphoma, as well as breast cancer and any otherand lymphoma, as well as breast cancer and any otherdisease requiring immune system regenerationdisease requiring immune system regeneration
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
The cardiovascularThe cardiovascularcirculatory systemcirculatory system’’s mains mainrole is to transportrole is to transportnutrients and oxygen tonutrients and oxygen tothe 50-100 trillion cellsthe 50-100 trillion cellsthat makes up our bodythat makes up our bodyand remove the wasteand remove the wastematerial from the body.material from the body.
The most prevalent diseaseThe most prevalent diseasethat affects the CVS is:that affects the CVS is:
1.1. AtherosclerosisAtherosclerosis2.2. HypertensionHypertension3.3. Acute myocardial infarctionAcute myocardial infarction4.4. StrokeStroke
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Target Diseases for Stem Cell TherapyTarget Diseases for Stem Cell TherapyHeart DiseaseHeart Disease ES cells can be induced to form cardiac muscle cells thatES cells can be induced to form cardiac muscle cells that
actually beat in cultureactually beat in culture When transplanted into damaged hearts, these cells canWhen transplanted into damaged hearts, these cells can
form gap junctions and contract in unison withform gap junctions and contract in unison withsurrounding cellssurrounding cells
HSCsHSCs can also be grafted into damaged heart muscle and, can also be grafted into damaged heart muscle and,in this new environment, are reprogrammed to producein this new environment, are reprogrammed to produceheart cells instead of blood cellsheart cells instead of blood cells
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Brief ReviewBrief Review
Endothelial Progenitor Cells
Mobilization, Differentiation, and HomingMihail Hristov; Wolfgang Erl; Peter C. WeberFrom the Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten,Ludwig-Maximilians-Universität, München, Germany
Arteriosclerosis, Thrombosis, and Vascular Biology.2003;23:1185.)© 2003 American Heart Association, Inc
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Figure 1. EPCs are bone marrow-derived cells that contribute topostnatal angiogenesis. EPCs(seen in purple at A) can bemobilized from the bone marrowstroma by various growthfactors and exit throughsinusoidal vessels. Once in thebloodstream (B), EPCs begin todifferentiate (indicated by thecolor change). Subsequently,these cells home to sites ofangiogenesis in capillary beds(C) and attach to theendothelium. Unknownmechanisms drive endothelialprecursors (red) to incorporateinto the endothelial wall or pro-angiogenic monocytes (blue) tolocate behind the endothelialwall and support the stabilityand viability of the localendothelium by paracrinemechanisms
Pediatric Research 59:26R-32R (2006)© 2006 International Pediatric Research Foundation, Inc.DOI: 10.1203/01.pdr.0000203553.46471.18
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Figure 3. Mechanism of EPC homing and differentiation. Recruitment andincorporation of EPCs into ischemic tissue requires a coordinated multistepprocess including mobilization, chemoattraction, adhesion, transmigration,migration, tissue invasion, and in situ differentiation. Factors that are proposed toregulate the distinct steps are indicated
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
ToToPreventPreventAtheroAthero--sclerosissclerosis
ControlControlcholesterocholesterol levell level
ControlControlHypertensHypertensionion
ExerciseExercise DietDiet NoNo
smokingsmoking
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Differentiation of embryonicDifferentiation of embryoniccells into the cardiac lineagecells into the cardiac lineage
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Physiol. Rev. 85: 1373-1416, 2005; doi:10.1152/physr “Cardiac Stem Cells andMechanisms of Myocardial Regeneration”
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Therapeutic Potential of EPC in AMITherapeutic Potential of EPC in AMI
Figure 2. TherapeuticFigure 2. Therapeuticpotential of potential of EPCsEPCs..IntracoronaryIntracoronary infusion of infusion ofEPCsEPCs in patients with in patients withAMI may have theAMI may have thepotential to restorepotential to restoremyocardial function tomyocardial function tothe damaged areathe damaged area..
EPC transplantationEPC transplantationincreases left ventricularincreases left ventricularejection fraction (LVEF),ejection fraction (LVEF),coronary blood flowcoronary blood flowreserve, and myocardialreserve, and myocardialviability and decreasesviability and decreasesleft ventricular end-left ventricular end-systolic volumesystolic volume(LVESV).(LVESV).6666
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Major Role CNS:Major Role CNS:The main role of the nervousThe main role of the nervoussystem is to relay electricalsystem is to relay electricalsignals through the body.signals through the body. The Thenervous system directsnervous system directsbehaviourbehaviour and movement and, and movement and,along with the endocrinealong with the endocrinesystem, controls physiologicalsystem, controls physiologicalprocesses such as digestion,processes such as digestion,circulation, etc.circulation, etc.
The most prevalent diseasesThe most prevalent diseasesthat affect the that affect the CNS is Stroke,CNS is Stroke,ParkinsonParkinson’’ss disease, disease,AlzheimerAlzheimer’’s disease, ALSs disease, ALSand Autismand Autism
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Proposed Mechanism for StemProposed Mechanism for StemCells in NeurodegenerativeCells in Neurodegenerative
DiseasesDiseases Implanted stem cells migrated &Implanted stem cells migrated &
integrated extensively throughout theintegrated extensively throughout thebrainbrain
Some of the transplanted cells replacedSome of the transplanted cells replaceddamaged nerve cells and transmitteddamaged nerve cells and transmittednerve impulsesnerve impulses integrate integrate electricallyelectricallyand and functionallyfunctionally into a diseased braininto a diseased brain
stem cells employ stem cells employ multiple mechanismsmultiple mechanisms not just cell replacementnot just cell replacement - which - whichcollaborate to benefit diseasecollaborate to benefit diseaseLee et al, Nature 2007
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Brain Cell TransplantationBrain Cell Transplantation
The identification and The identification and localisationlocalisation of neural stem cells, of neural stem cells,both embryonic and adult, has been a major focus ofboth embryonic and adult, has been a major focus ofcurrent research.current research.
Potential targets of neural stem cell transplantsPotential targets of neural stem cell transplants
1. include stroke, 2. spinal cord injury,1. include stroke, 2. spinal cord injury,andand
3. neurodegenerative diseases such as3. neurodegenerative diseases such asParkinson's Disease, 4. AlzheimerParkinson's Disease, 4. Alzheimer
Stem cells can provide dopamine - a chemical lacking inStem cells can provide dopamine - a chemical lacking invictims of Parkinson's Diseasevictims of Parkinson's Disease
Over 250 patients have already been transplanted withOver 250 patients have already been transplanted withhuman fetal tissuehuman fetal tissue
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Target Diseases for Stem Cell TherapyTarget Diseases for Stem Cell Therapy
Brain and Spinal CordBrain and Spinal CordInjuryInjury
Neural stem cells can beNeural stem cells can beisolated from adult brains orisolated from adult brains orgenerated from ES cells ingenerated from ES cells incultureculture
HSCsHSCs can also be can also betransplanted into the braintransplanted into the brainwhere they arewhere they arereprogrammed to generatereprogrammed to generateneurons and neurons and glialglial cells cells
Potential applicationsPotential applicationsinclude Parkinsoninclude Parkinson’’s disease,s disease,ALS, HuntingtonALS, Huntington’’s disease,s disease,stroke, Alzheimerstroke, Alzheimer’’s disease,s disease,paralysisparalysis
Animal and early humanAnimal and early humantrials are underwaytrials are underway
Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.
IschemicIschemicStrokeStroke
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
CerebralCerebralHemorrhHemorrhageage
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Spinal Cord InjuriesSpinal Cord InjuriesHwang Mi-Soon: SouthKorea
Paralyzed 19 years
Multipotent adult stem cellsinjectedinto her spinal cord
Currently: debilitating pain
Published in 2005 (Cytotherapy)
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
ParkinsonParkinson’’s Disease :s Disease :Degeneration of brain cellsDegeneration of brain cells
Cells in theCells in thesubstantiasubstantia nigranigra
Loss of theLoss of thechemicalchemicaldopaminedopamine
No clearNo clearreason whyreason why
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Osteoarthritis and AutoimmuneOsteoarthritis and AutoimmuneDiseasesDiseases
MesenchymalMesenchymalstem cells arestem cells areused to beused to beinserted into theinserted into thesynovialsynovial cavity cavitywhere theywhere theytransdifferentiatetransdifferentiateintointochondroblastschondroblastsand form newand form newcartilagecartilage
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Osteoarthritis of the Knee JointOsteoarthritis of the Knee Joint
MesenchymalMesenchymal stem stemcells are implantedcells are implantedinto ainto abiodegradablebiodegradablescaffold andscaffold andinserted into theinserted into thesynovialsynovial cavity cavitywhere they willwhere they willtransdifferentiatetransdifferentiateinto new cartilageinto new cartilage
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Target Diseases for Stem Cell TherapyTarget Diseases for Stem Cell Therapy
Type 1 DiabetesType 1 Diabetes
Patients lack pancreaticPatients lack pancreaticbeta cells and cannotbeta cells and cannotproduce insulinproduce insulin
Insulin-producingInsulin-producingstructures similar tostructures similar topancreatic islets have beenpancreatic islets have beengenerated from mouse ESgenerated from mouse EScells in culturecells in culture
It may also be possible toIt may also be possible toisolate pancreatic stemisolate pancreatic stemcells from adult tissuecells from adult tissue
Early stage of developmentEarly stage of development
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
Stem Cell BankingStem Cell BankingCord Blood bankingCord Blood banking is now becoming popular for is now becoming popular for
autologousautologous as well as for as well as for allogeneicallogeneic donor donorAdult Peripheral BloodAdult Peripheral Blood collection and collection and
cryopreservationcryopreservation can also be used for future can also be used for futurediseasesdiseases
Endothelial progenitor cells and Endothelial progenitor cells and MesenchymalMesenchymalstem cellsstem cells are potentially are potentially usefullusefull for many clinical for many clinicalapplicationsapplications
Stem cells can be collectedStem cells can be collected from UCB, from UCB,AdipocytesAdipocytes and Peripheral Blood by and Peripheral Blood by ApheresisApheresis
Stem cells can be Stem cells can be CryopreservedCryopreserved for use in for use inCancers, CAD, Stroke, Diabetes, Burns, Spinal CordCancers, CAD, Stroke, Diabetes, Burns, Spinal Cordinjury, Osteoarthritis, Regenerative medicine, etc.injury, Osteoarthritis, Regenerative medicine, etc.
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
ConclusionsConclusionsAdult stem cellsAdult stem cells can be obtained from can be obtained from
BM, Fetus, BM, Fetus, hUCBhUCB, , AdipocytesAdipocytes and andPeripheral blood, It will not create anyPeripheral blood, It will not create anyethical problemsethical problems
Adult stem cellsAdult stem cells from fetuses and from fetuses and hUCBhUCBare the most are the most PLASTICPLASTIC
Embryonic stem cellsEmbryonic stem cells obtained from the obtained from theINNER CELL MASS for THERAPEUTICINNER CELL MASS for THERAPEUTICpurposes are allowed in 38 countries (UK,purposes are allowed in 38 countries (UK,Sweden, Belgium, Netherland, China, India,Sweden, Belgium, Netherland, China, India,Korea, Taiwan, Singapore, Malaysia etc.)Korea, Taiwan, Singapore, Malaysia etc.)
Embryonic stem cellsEmbryonic stem cells for reproductive cloning for reproductive cloningis not allowed in ALL COUNTRIESis not allowed in ALL COUNTRIES
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008
5. 5. MesenchymalMesenchymal Stem Cells from BM, Stem Cells from BM,Fetuses, Fetuses, hUCBhUCB, can be used as, can be used asProgenitor Neuronal CellsProgenitor Neuronal Cells for fortransplantation in Neurodegenerativetransplantation in NeurodegenerativeDiseases.Diseases.
6. 6. EPCsEPCs as well as MSC from BM, as well as MSC from BM, hUCBhUCB,,AdipocytesAdipocytes and peripheral blood and peripheral blood can be can beused for AMIused for AMI
7. 7. Stem Cell ResearchStem Cell Research should become a should become aPRIORITY to be carried out in IndonesiaPRIORITY to be carried out in Indonesia
8. 8. Academic Institutions, Business andAcademic Institutions, Business andGovernment (ABG)Government (ABG) must Cooperate Closely must Cooperate Closelyto Stimulate RND for the Benefit of Societyto Stimulate RND for the Benefit of Society
dr.Boenjamin Setiawan,Ph.D.dr.Boenjamin Setiawan,Ph.D.Simposium Asosiasi Sel PuncaSimposium Asosiasi Sel PuncaIndonesia, 2 Febr 2008Indonesia, 2 Febr 2008