8th National Symposium on Inflammatory Bowel Diseases

29th of September - 1st of October 2016 Crowne Plaza Bucharest, Romania

www.rccc-congress.ro www.rccc.ro

Organizing scientific committee Răzvan Iacob, Dan Gheonea, Alexandru Lupu, Carmen Preda

President Mircea Diculescu

RCCCRomanian Crohn`s and Colitis Club

Dear Guests, Friends and Colleagues,We meet again in Bucharest this year for a new National Meeting in the dy-namic field of IBD. The Inflammatory Bowel Disease pathology has at least three hot spots for Romania at the beginning of the XXIst century: increasing incidence and severity, paralleled by the better knowledge for basic etiopath-ogenic mechanisms and novel therapeutic solutions.

With the valuable help of our European friends, our National Symposium is beginning to have an International format, supporting the quality of Romania as an active member of ECCO.

We will try this year, in less than three days, to start a trip through the European IBD landscape, sharing our experience with coleagues from abroad, with topics related to current diagnostic tools, as well as novel therapeutic solutions. Along dedicated conferences, symposia and courses, our Meeting will have a Young IBD Investigators Session, pediatric topics (we greet with this occasion the recently established pRCCC), patients dedicated events and an IBD Nurse meeting.

We will definitely not be able to cover all the aspects of this complex pathol-ogy or to be able to share all the experience that we would like, but we hope that this Meeting will be able to raise at the level of your expectations and increase your knowledge with new information.

Kind regards, In the name of the Organizing Commitee,

Mircea DiculescuBucharest, 29.09.2016

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More details: www.ecco-ibd.eu

11:00 - 14.00 Registration

12.00 - 13.00Leading Change in IBD – invited only

14.00 - 14.15 Opening ceremony – Mircea Diculescu, Dan Dumitraşcu, Liana Gheorghe

14.15 - 15.45 Annual IBD Course.How to define clinically significant inflammation in IBD? (supported by Takeda)Chair: Cristian Gheorghe, Eugen DumitruThe role of endoscopy – Cristian GheorgheInflamatory Bowel Disease – The evolution of histological features from ac-tive disease to intestinal healing – Gabriel Becheanu, Mona Dumbrava What should we know about the sectional imaging -CT and MRI- in the diagnosis of inflammatory bowel disease – Ioana Lupescu

15.45 - 16.15 Coffee break

16:15 - 16:30 The future starts now! - Proposal for the new electronic file to support biological treatment prescription in Romania – Bogdan Mateescu

16.30 - 17.30 Biomarkers in IBDChair: Lucian Negreanu, Ciprian BriscStool biomarkers in IBD – Andreea BengusNew serological markers to predict IBD outcome – Carmen PredaMucosal biomarkers in IBD – Şerban Gologan, Mihai AndreiGenomic and proteomic bio-markers in IBD – Roxana Zaharie

Thursday 29th of september 2016

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Romanian Crohn’s and Colitis Club (RCCC) VIIIth National Symposium on Inflammatory Bowel Diseases, 29th of September - 1st of October 2016, Crowne Plaza Bucharest, Romania

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17.30 - 18.15 TAKEDA Symposium: IBD treatment at the crossroadsChair: Cristian Gheorghe Speakers: Anca Trifan, Liana Gheorghe

18.15 - 19.15 Me&IBD: ASPIIR Event (patients association)Chair: Liana Gheorghe, Isabella Grosu

19.30 Opening Cocktail

8.00 - 09.30 Travelling through Eastern Europe. From epidemiology to therapeutic particularities (I) Chair: Boris Vucelic, Mircea Diculescu, Dino TarabarIBD Epidemiology in Moldova – Svetlana TurcanOptimization of IBD Therapy – Dino TarabarFrom Epidemiology to Therapeutic Particularities of IBD in North-East of Romania: IBD Prospect Data – Cristina Cijevschi Prelipcean, Anca Trifan, Cătălina MihaiEpidemiology of IBD and current situation with biologic therapy in Croatia – Boris Vucelic

9.30 - 10.00 Coffee break

10.00 - 10.30 State of the Art Lecture Chair: Cristina Cijevschi PrelipceanIron deficiency in IBD. Patients versus physicians perspectives – Silvio Danese

10.30 - 12.00Travelling through Eastern Europe. From epidemiology to therapeutic particularities (II)Chair: Milan Lukáš, Adrian Goldiş, Tamas MolnarEpidemiology of IBD in Bucharest-Ilfov County, preliminary report of Epirom Registry – Răzvan Iacob, Simona Necula, Anca Dimitriu, Monica Cojocaru and Liana Gheorghe for Epirom Study Group.Are there differences between IBD patients from Eastern and Western Europe ? – Adrian Goldiş

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Friday 30th of September

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Predictors of therapeutic failure, colectomy and pouchitis in ulcerative colitis – Tamas MolnarWhat we learned about biosimilar infliximab on therapy of IBD patients ? Experience of one tertiary site in the Czech Republic – Milan Lukáš

12.00 - 13.00 ABBVIE UC Symposium - UC today: from clinical to practiceChair: Mircea DiculescuSpeakers: Marc Ferrante, Anca Trifan, Bogdan Mateescu, Lucian Negreanu

13.00 - 14.00 Lunch

13.00 - 14.00 Ask the expert: UC approach in a changing therapeutic landscape (lunch session)Registration required by email: office.rccc@gmail.com. Limited number of participants; deadline for registration 28.09.2016.Chair: Liana GheorgheInvited speaker: Marc FerranteSupported by Abbvie

14.00 - 14.20 Innergy Symposium: Inflammatory Bowel Disease from the perspective of intestinal dysbiosis. New evidence.Speaker: Liana Gheorghe

14.20 - 14.40 Sofar Symposium: "Something new on the Eastern Front ?" Speaker: Lucian Negreanu

14.40 - 15.10 Review of recent clinical trials in IBD. Liana Gheorghe

15.10 - 16.00 Gastroenterology - Rheumatology Joint MeetingChair: Mihai Bojincă, Bogdan MateescuEvidence of Rheumatological manifestations in IBD – Anca Marineaţa, Elena Rezuş, Cristina Cijevschi PrelipceanThe management of osteoarticular pathology in IBD – Violeta BojincăParadoxical inflammation induced by anti-TNF agents in patients with IBD – Corina Pop

16.00 - 16.30 Coffee Break

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16.30 - 18.00 Controversies in the management of IBDChair: Cristina Cijevschi Prelipcean, Marcel TanţăuCMV reactivation in IBD – diagnostic and therapeutic challenges – Speranţa IacobThe use of ultrasonography in IBD – Zeno SpârchezThe role of endoscopic therapy in Crohn’s Disease – Marcel TanţăuDysplasia in IBD: differences between theory and clinical practice – Cătălin SfartiStem cell therapies in IBD – Răzvan Iacob

18.00 - 19.00 ABBVIE CD Symposium – What is “right time” in CD? Clinical cases discussionChair: Liana GheorgheSpeakers: Cristina Cijevschi Prelipcean, Eugen Dumitru, Adrian Goldiş, Alina Tanţău, Cătălina Mihai

19:00 Dinner

8.00 - 9.00 Young IBD investigators – selected papers and challenging IBD cases.Chair: Anca Trifan, Dan GheoneaFistulizing Crohn’s Disease - diagnostic and therapeutic challenges – Alexandru Lupu, Corina MeianuHow do we manage the loss of response to biological therapy ? – Ana Maria Singeap, Anca TrifanIs fecal calprotectin an accurate tool to assess the mucosal inflammation among children with inflammatory bowel diseases? – Belei Oana, Sime-drea Ioan, Olariu Laura, Marcovici Tamara, Mărginean OtiliaAnemia in ulcerative colitis - clinical experience in the North-East of Romania – Mihaela Dranga, Otilia Gavrilescu, Cătălina Mihai, Cristina Cijevschi PrelipceanBiological therapy in post-operatory setting of Crohn’s disease (CD): a national cohort study – Carmen Preda, Larisa-Elena Fulger, Liana Gheorghe, Cristian Gheorghe, Adriana Andrei, Sorin Andrei, Sandra Irina, Lucian Negreanu, Mircea Manuc, Cătălin Dutei, Mircea Diculescu

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Saturday 1st of October

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9.00 - 9.30 State of the Art Lecture Chair: Liana GheorgheThe Slovenian experience with Biosimilars – Ivan Ferkolj

9:30 - 10:30 Nutrition in IBDChair: Daniela Şerban, Mircea ManucWhy do we use enteral nutrition in pediatric Crohn’s Disease? – Daniela ŞerbanNutrition therapy for IBD patients – Roxana Vădan Vitamin D deficiency and IBD – Alina TanţăuExclusion diets in IBD – Maria Ispas

10.30 - 11.00. Coffee Break

11.00 - 12.00 MSD Symposium: New insights and technologies to improve management and outcomes in IBDChair: Cristina Cijevschi Prelipcean, Liana GheorgheSpeakers: Milan Lukáš, Alessandro Armuzzi

12.00 - 12.30 State of the Art LectureChair: Oliviu Pascu, Adrian GoldişPopulation-based study; from epidemiology to functional analyses – Corinne-Gower Rousseau

12.30 - 13.00 Antoine Cortot – Honorary Member of RCCC Award Diploma - State of the Art Lecture: Impact of age on IBD: Epidemiologic approach from a population-based study

13.00 - 14.00 IBD – present and futureChair: Carol Stanciu, Alina TanţăuSeverity assessment in IBD – Oliviu PascuA view from the Top: why and how to return safe and sound – Bogdan Mateescu2016: Biotherapies, biosimilars and other new assets for IBD treatment – Lucian Negreanu Healing in IBD ‘ 2016 - what is the meaning – Alexandru Oproiu

14.00 - 14.30Closing Ceremony: Poster Awards – Liana Gheorghe, Mircea Diculescu, Cristina Cijevschi Prelipcean

14:30 Farewell Cocktail

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8.00-16.00IBD Nurse Symposium8.00 - 9.30The role of IBD nurse in the management of IBD patient on biological therapy (Supported by MSD). Speakers: Aura Georgescu, Cornelia Ionică, Corina Gabriela Meianu

9.30 - 11.00Psychological aspects in IBD management – the interrelation doctor-nurse-psychologist-IBD patient. (Supported by ASPIIR)Isabella Grosu, Ingrid Anette Hoff Melkersen

11.00 - 11.30 Coffee break

11.30 - 13.00The particularities of endoscopic management in IBD, from the IBD nurse point of view. Costin Mangiru, Monica Cojocaru

13.00 - 14:00 Lunch break

14.00 - 15.30The role of IBD nurse in nutritional support of IBD patients (Support-ed by Fresenius Kabi)Teodora Andrei, Roxana Vădan

15.30 - 16.00 Closing remarks

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Friday 30th of September

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Poster session1. Evidences of Extraintestinal Manifestations in Inflammatory Bowel Disease in Northeastern Romania. Anca Cardoneanu, Elena Rezus, Raluca Cezara Popa, Iolanda Popa, Irina Ungureanu, Ancuţa Didita, Otilia Gavrilescu, Mihaela Dranga, Cristina Cijevschi Prelipcean. Gastroenterology and Hepatology Institute, Iași

2. Treatment adherence and beliefs towards medication in patients with chronic immune-mediated inflammatory diseases (IMID): Romanian results from ALIGN study. Mihai Bojincă1, Carmen M. Curea2, Bogdan R. Mateescu2, Carina Mihai1, Lucian Negreanu3, Rodica Olteanu2, Dana L. Iosub4, Diana Marina4. 1. "Dr. Ion Cantacuzino" Clini-cal Hospital, Bucharest, Romania; 2. Colentina Clinical Hospital, Bucharest, Romania; 3. Emergency University Hospital Bucharest, Romania; 4. AbbVie SRL, Bucharest, Romania

3. The adverse effects of inflammatory bowel disease (IBD) treatment in a tertiary referral center. Laura Lucaciu1, Oana Farcau1, Paula Szanto1, Cristina Pojoga1, Seicean R2, Andrada Seicean1. 1.IRGH ‘’Prof. Dr. O. Fodor’’, Cluj-Napoca; 2. Regional Clinical Emergency Hospital, General Surgery, Cluj-Napoca

4. Acute generalized exanthematous pustulosis induced by anti-TNF therapy in Crohn’s disease: an unusual case. Laura Lucaciu1, Simona Senila2, Andrada Seicean1. 1. IRGH ‘’Prof. Dr. O. Fodor’’, Cluj-Napoca; 2. Regional Clinical Emergency Hospital, Gen-eral Surgery, Cluj-Napoca

5. Favorable Clinical and endoscopic disease activity is paralleled by an increase in exposure to biologic therapy: preliminary results from a prospective IBD cohort. Andreea Bengus, Th. Voiosu, Monica Ioniţă, A. Voiosu, R.B. Mateescu. Colentina Clinical Hospital, Gastroenterology Departament

6. Time to switch in IBD. B. Busuioc, A. Bengus, M. Marinescu, C. Mocanu, R. B. Ma-teescu. Colentina Clinical Hospital, Gastroenterology Departament

7. Serum lysozyme in Inflammatory Bowel Disease. Andra Consuela Ionescu, Alina Vasilescu, Laura Gaman, Irina Stoian, Valeriu Atanasiu, Ionescu Lucian , Mircea Di-culescu. Fundeni Clinical Institute Bucharest

8. Effect of infliximab on bone metabolism in inflammatory bowel disease patients. Ancuta Didita2, Irina Oana Ungureanu2, Mircea Alexandru Badea1,2, Olivia Jigaranu2, Cătălina Mihai 1,2, Cristina Cijevschi-Prelipcean 1,2. 1 University of Medicine and Pharmacy “Grigore T. Popa” Iași; 2 Institute of Gastroenterology and Hepatology, Iași

9. Biological therapy and anemia evolution in inflammatory bowel disease. Iolanda Valentina Popa 1,2, Catalina Mihai 1,2, Mihaela Dranga 1,2, Mircea Badea 1,2, Raluca Cezara Popa 2, Ancuţa Didita 2, Otilia Gavrilescu 1,2, Cristina Cijevschi-Prelipcean 1,2. 1 University of Medicine and Pharmacy "Grigore T. Popa" Iași ; 2 Institute of Gastroenterology and Hepatology, Iași

10. Vitamin D deficiency and disease activity in ulcerative colitis patients? Otilia Gavrilescu1, Ancuța Didița2, Raluca Cezara Popa2, Alexandra Savin2, Cătălina Mihai 1,2,

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Cristina Cijevschi Prelipcean 1,2. 1 Grigore T. Popa University of Medicine and Pharmacy; 2 Institute of gastroenterology and hepatology, Iași

11. Biological therapy in ulcerative colitis and body mass index. Oana Irina Ungureanu2, Anca Cardoneanu1, Iolanda Popa 1,2, Mihaela Dranga 1,2, Cristina Cijevschi-Prelipcean 1,2 Cătălina Mihai 1,2. 1 University of Medicine and Pharmacy “Grigore T. Popa” Iași; 2 Institute of Gastroenterology and Hepatology, Iași

12. Is there an association between location and inflamatory status in crohn’s dis-ease? Alexandra Savin, Anca Cardoneanu, Ana-Maria Chiosa, Bogdan Cucuteanu, Cristina Cijevschi Prelipcean, Cătălina Mihai. Institute of Gastroenterology and Hepatology, Iași

13. Neutrophyl-lymphocyte ratio as a predictive marker of Crohn’s disease activity. Raluca Cezara Popa, Otilia Gavrilescu, Mircea Badea, Mihaela Dranga, Cătălina Mihai, Cristina Cijevschi Prelipcean. Institute of Gastroenterology and Hepatology, Iași

14. Crohn’s disease and pulmonary tuberculosis: management challenge. Roxana Maxim², Anca Trifan¹², Irina Ciortescu¹², Emanuela Sarca¹, Oana Cristina Stoica², Alina Pleșa¹², Carol Stanciu¹. 1. Institute of Gastroenterology and Hepatology Iasi, Romania; 2. University of Medicine and Pharmacy “Gr.T. Popa” Iaşi, România

15. Cutaneous manifestation in ulcerative colitis: diagnostic and therapeutic chal-lenge. Oana Cristina Stoica1, Anca Trifan 1,2, Irina Gîrleanu 1,2, Oana Tănase2, Cătălin Alexandru Chihaia 2, Laura Statescu1, Issa Raid3, Carol Stanciu2. 1. “Gr. T. Popa” University of Medicine and Pharmacy, Iași, Romania; 2. Institute of Gastroenterology and Hepatology, Iași, Romania; 3. "St Spiridon" Emergency Hospital, Department of Plastic Surgery, Iași, Romania

16. Variability of endoscopic appearance in ulcerative colitis patients hospitalized in a tertiary center from North-East Romania. Oana Stoica1, Anca Trifan 1,2, Irina Gîrleanu 1,2, Roxana Maxim1,Camelia Cojocariu 1,2, A.-M. Singeap 1,2, Carol Stanciu2. 1. “Gr. T. Popa” University of Medicine and Pharmacy, Iași, Romania; 2. Institute of Gastroenterology and Hepatology, Iași, Romania

17. Pulmonary adenocarcinoma in an immunosuppressed patient with Crohn’s dis-ease. Caterina Dănilă, Lidia Ciobanu, Oliviu Pascu. Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca

18. Correlation between vitamin deficiencies and disease activity in patients diag-nosed with inflammatory bowel diseases (IBD) in Western Romania. Daniela Lazăr, Adrian Goldis. Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy “Victor Babeș”, Timișoara, Romania.

19. Incidence of latent and active tuberculosis in a Romanian cohort of BCG vaccinated, immunosuppressed patients with moderate-to-severe Crohn's disease treated with bio-logical therapy. Preda CM, Fulger LE, Gheorghe C, Gheorghe L, Manuc M, Negreanu L, Meianu C, Dutei C, Slavulete BI, Ciora C, Diculescu MM. Fundeni Clinical Institute Bucharest. University of Medicine and Pharmacy Carol Davila, Bucharest

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GENERAL INFORMATIONDate and VenueDate: 29th of September - 1st of October 2016 Location: Crowne Plaza Bucharest, Romania

OrganizersRomanian Crohn`s and Colitis Club

Official LanguageScientific presentation will be held in Romanian language presentation slides in English

CME AccreditationThe Annual IBD Symposium will be credited by Romanian Medical College with Continuing Medical Education Credits 12 CMR.

Certificate of AttendanceEach participant will receive a Certificate of attendance, which can be picked-up from the InfoDesk, starting from October 1st, at 13 o’clock.

InfoDeskThe Annual IBD Symposium InfoDesk will be located in conference room lobby The working schedule will be:Thursday, September 29th 2015 15:30 – 18:30Friday, September 30th 2016 8:00 – 19:30Saturday, October 1st 2016 8:00 – 16:30 Program HandbookEach participant will receive from the InfoDesk the backpack includes program hand-book and sponsors materials.

BadgesParticipants are requested to wear their badge at all times while inside the premises.

Workshop accessFor access in the Annual IBD Symposium InfoDesk will be located in conference room lobby room you will be using the badge which you will receive after registering at the InfoDesk.

CateringParticipants will serve the coffee breaks/lunch in the designated spaces, as detailed in the Program Handbook. Access to tables is based on vouchers.

Mobile phone Mobile phones must be switched off during all sessions.

SmokingSmoking is allowed only in designated areas.

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Main Sponsors

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DATE: 29th of September - 1st of October 2016LOCATION: Crowne Plaza Hotel, Bucharest, Romania

ORGANIZING SOCIETIES/INSTITUTIONS:Romanian Crohn`s and Colitis Club ( RCCC ) PRESIDENT:Mircea Diculescu ORGANIZING SCIENTIFIC COMMITTEE:Răzvan Iacob, Dan Gheonea, Alexandru Lupu, Carmen Preda OFFICIAL LANGUAGE:The official language of the course is English.

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