Rare pulmonary diseases and orphan drugs: where do we ... · Spagnolo P, Sverzellati N, Rossi G,...

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Rare pulmonary diseases and orphan drugs: where do we stand and where are we going to?

Harari S, Humbert M, Blasi F, Collard HR, Matucci-Cerinic M, Simonneau G, Vancheri C, Wells AU,Cottin V.Eur Respir Rev. 2015 Sep;24(137):375-7. doi: 10.1183/16000617.0051-2015. No abstract available.

PMID: 26324798 Free Article

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IPF, comorbidities and management implications.

Vancheri C, Cottin V, Kreuter M, Hilberg O.Sarcoidosis Vasc Diffuse Lung Dis. 2015 Aug 3;32(1 Suppl):17-23.

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Effects of thymosin β4 and its N-terminal fragment Ac-SDKP on TGF-β-treated human lungfibroblasts and in the mouse model of bleomycin-induced lung fibrosis.

Conte E, Iemmolo M, Fruciano M, Fagone E, Gili E, Genovese T, Esposito E, CuzzocreaS, Vancheri C.Expert Opin Biol Ther. 2015 Jul;15 Suppl 1:211-21. doi: 10.1517/14712598.2015.1026804. Epub 2015 Jun 22.

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Efficacy of pirfenidone for idiopathic pulmonary fibrosis: An Italian real life study.

Harari S, Caminati A, Albera C, Vancheri C, Poletti V, Pesci A, Luppi F, Saltini C, Agostini C,Bargagli E, Sebastiani A, Sanduzzi A, Giunta V, Della Porta R, Bandelli GP, Puglisi S, Tomassetti S,Biffi A, Cerri S, Mari A, Cinetto F, Tirelli F, Farinelli G, Bocchino M, Specchia C, Confalonieri M.Respir Med. 2015 Jul;109(7):904-13. doi: 10.1016/j.rmed.2015.04.010. Epub 2015 Apr 25.

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The role of tyrosine kinases in the pathogenesis of idiopathic pulmonary fibrosis.

Grimminger F, Günther A, Vancheri C.Eur Respir J. 2015 May;45(5):1426-33. doi: 10.1183/09031936.00149614. Epub 2015 Mar 5. Review.

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In vitro antiproliferative effect of trastuzumab (Herceptin ) combined with cetuximab (Erbitux ) in a

model of human non-small cell lung cancer expressing EGFR and HER2.

Privitera G, Luca T, Musso N, Vancheri C, Crimi N, Barresi V, Condorelli D, Castorina S.Clin Exp Med. 2015 Feb 26. [Epub ahead of print]

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Idiopathic pulmonary fibrosis: an update.

Spagnolo P, Sverzellati N, Rossi G, Cavazza A, Tzouvelekis A, Crestani B, Vancheri C.Ann Med. 2015 Feb;47(1):15-27. doi: 10.3109/07853890.2014.982165. Epub 2015 Jan 22.

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Protein profile of exhaled breath condensate determined by high resolution mass spectrometry.

Muccilli V, Saletti R, Cunsolo V, Ho J, Gili E, Conte E, Sichili S,Vancheri C, Foti S.J Pharm Biomed Anal. 2015 Feb;105:134-49. doi: 10.1016/j.jpba.2014.11.050. Epub 2014 Dec 5.

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Anti-inflammatory and antifibrotic effects of resveratrol in the lung.

Conte E, Fagone E, Fruciano M, Gili E, Iemmolo M, Vancheri C.Histol Histopathol. 2015 May;30(5):523-9. Epub 2014 Dec 16. Review.

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Combination therapy: the future of management for idiopathic pulmonary fibrosis?

Wuyts WA, Antoniou KM, Borensztajn K, Costabel U, Cottin V, Crestani B, Grutters JC, Maher TM,Poletti V, Richeldi L,Vancheri C, Wells AU.Lancet Respir Med. 2014 Nov;2(11):933-42. doi: 10.1016/S2213-2600(14)70232-2. Epub 2014 Nov 3. Erratum

in: Lancet Respir Med. 2015 Jan;3(1):e2.

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Altered surfactant homeostasis and alveolar epithelial cell stress in amiodarone-induced lungfibrosis.

Mahavadi P, Henneke I, Ruppert C, Knudsen L, Venkatesan S, Liebisch G, Chambers RC, Ochs M,Schmitz G, Vancheri C, Seeger W, Korfei M, Guenther A.Toxicol Sci. 2014 Nov;142(1):285-97. doi: 10.1093/toxsci/kfu177. Epub 2014 Aug 27.

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Clinical and radiological features of idiopathic interstitial pneumonias (IIPs): a pictorial review.

Palmucci S, Roccasalva F, Puglisi S, Torrisi SE, Vindigni V, Mauro LA, Ettorre GC, PiccoliM, Vancheri C.Insights Imaging. 2014 Jun;5(3):347-64. doi: 10.1007/s13244-014-0335-3. Epub 2014 May 22.

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Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis.

Richeldi L, du Bois RM, Raghu G, Azuma A, Brown KK, Costabel U, Cottin V, Flaherty KR, HansellDM, Inoue Y, Kim DS, Kolb M, Nicholson AG, Noble PW, Selman M, Taniguchi H, Brun M, Le MaulfF, Girard M, Stowasser S, Schlenker-Herceg R, Disse B, Collard HR; INPULSIS Trial Investigators.N Engl J Med. 2014 May 29;370(22):2071-82. doi: 10.1056/NEJMoa1402584. Epub 2014 May 18. Erratum in: N Engl

J Med. 2015 Aug 20;373(8):782.


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Pirfenidone in idiopathic pulmonary fibrosis: expert panel discussion on the management of drug-related adverse events.

Costabel U, Bendstrup E, Cottin V, Dewint P, Egan JJ, Ferguson J, Groves R, Hellström PM, KreuterM, Maher TM, Molina-Molina M, Nordlind K, Sarafidis A, Vancheri C.Adv Ther. 2014 Apr;31(4):375-91. doi: 10.1007/s12325-014-0112-1. Epub 2014 Mar 18. Erratum in: Adv Ther. 2014

May;31(5):575-6.


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Effect of pirfenidone on proliferation, TGF-β-induced myofibroblast differentiation and fibrogenicactivity of primary human lung fibroblasts.

Conte E, Gili E, Fagone E, Fruciano M, Iemmolo M, Vancheri C.Eur J Pharm Sci. 2014 Jul 16;58:13-9. doi: 10.1016/j.ejps.2014.02.014. Epub 2014 Mar 12.

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Thymosin β4 reduces IL-17-producing cells and IL-17 expression, and protects lungs from damage





















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in bleomycin-treated mice.

Conte E, Iemmolo M, Fagone E, Gili E, Fruciano M, Genovese T, Esposito E, CuzzocreaS, Vancheri C.Immunobiology. 2014 Jun;219(6):425-31. doi: 10.1016/j.imbio.2014.02.001. Epub 2014 Feb 14.

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Reconciling healthcare professional and patient perspectives in the development of disease activityand response criteria in connective tissue disease-related interstitial lung diseases.

Saketkoo LA, Mittoo S, Frankel S, LeSage D, Sarver C, Phillips K, Strand V, Matteson EL;OMERACT Connective Tissue Disease–Interstitial Lung Diseases Working Group; OMERACTConnective Tissue Disease-Interstitial Lung Diseases Working Group.J Rheumatol. 2014 Apr;41(4):792-8. doi: 10.3899/jrheum.131251. Epub 2014 Feb 1. Review.


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Connective tissue disease related interstitial lung diseases and idiopathic pulmonary fibrosis:provisional core sets of domains and instruments for use in clinical trials.

Saketkoo LA, Mittoo S, Huscher D, Khanna D, Dellaripa PF, Distler O, Flaherty KR, Frankel S,Oddis CV, Denton CP, Fischer A, Kowal-Bielecka OM, LeSage D, Merkel PA, Phillips K, Pittrow D,Swigris J, Antoniou K, Baughman RP, Castelino FV, Christmann RB, Christopher-Stine L, CollardHR, Cottin V, Danoff S, Highland KB, Hummers L, Shah AA, Kim DS, Lynch DA, Miller FW,Proudman SM, Richeldi L, Ryu JH, Sandorfi N, Sarver C, Wells AU, Strand V, Matteson EL, BrownKK, Seibold JR; CTD-ILD Special Interest Group.Thorax. 2014 May;69(5):428-36. doi: 10.1136/thoraxjnl-2013-204202. Epub 2013 Dec 24. Erratum in: Thorax. 2014

Sep;69(9):834. CTD-ILD Special Interest Group [added]; multiple investigator names added.


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Human lung fibroblasts increase CD4(+)CD25(+)Foxp3(+) T cells in co-cultured CD4(+)lymphocytes.

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Common pathways in idiopathic pulmonary fibrosis and cancer.

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Mapping the future for pulmonary fibrosis: report from the 17th International Colloquium on Lungand Airway Fibrosis.

Richeldi L, Collard HR, du Bois RM, Jenkins G, Kolb M, Maher TM, Raghu G, Vancheri C, LaurentGJ.Eur Respir J. 2013 Jul;42(1):230-8. doi: 10.1183/09031936.00038613. Epub 2013 May 16.


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Comparative proteome analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF),non-specific interstitial pneumonia (NSIP) and organ donors.

Korfei M, von der Beck D, Henneke I, Markart P, Ruppert C, Mahavadi P, Ghanim B, Klepetko W,Fink L, Meiners S, Krämer OH, Seeger W, Vancheri C, Guenther A.J Proteomics. 2013 Jun 24;85:109-28. doi: 10.1016/j.jprot.2013.04.033. Epub 2013 May 6.


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Differentiation of human adipose stem cells into neural phenotype by neuroblastoma- or olfactoryensheathing cells-conditioned medium.

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Interferon-γ and interleukin-17 production from PPD-stimulated PBMCss of patients with pulmonarytuberculosis.

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PI3K p110γ overexpression in idiopathic pulmonary fibrosis lung tissue and fibroblast cells: in vitroeffects of its inhibition.

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Thymosin β4 protects C57BL/6 mice from bleomycin-induced damage in the lung.

Conte E, Genovese T, Gili E, Esposito E, Iemmolo M, Fruciano M, Fagone E, Pistorio MP, Crimi N,Cuzzocrea S, Vancheri C.Eur J Clin Invest. 2013 Mar;43(3):309-15. doi: 10.1111/eci.12048. Epub 2013 Jan 16.

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Hot of the breath: mortality as a primary end-point in IPF treatment trials: the best is the enemy ofthe good.

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Protective effects of thymosin β4 in a mouse model of lung fibrosis.

Conte E, Genovese T, Gili E, Esposito E, Iemmolo M, Fruciano M, Fagone E, Pistorio MP, Crimi N,Cuzzocrea S, Vancheri C.



















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Ann N Y Acad Sci. 2012 Oct;1269:69-73. doi: 10.1111/j.1749-6632.2012.06694.x.

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A progression-free end-point for idiopathic pulmonary fibrosis trials: lessons from cancer.

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Idiopathic pulmonary fibrosis: an altered fibroblast proliferation linked to cancer biology.

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Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts intomyofibroblasts: the role of class I P110 isoforms.

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The European IPF Network: towards better care for a dreadful disease.

Guenther A; European IPF Network.Eur Respir J. 2011 Apr;37(4):747-8. doi: 10.1183/09031936.00012111. No abstract available.


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Resveratrol inhibits transforming growth factor-β-induced proliferation and differentiation of ex vivohuman lung fibroblasts into myofibroblasts through ERK/Akt inhibition and PTEN restoration.

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Reactive oxygen species are required for maintenance and differentiation of primary lung fibroblastsin idiopathic pulmonary fibrosis.

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Antiproliferative effects induced by guanine-based purines require hypoxanthine-guaninephosphoribosyltransferase activity.

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Circulating fibrocytes as a marker of liver fibrosis in chronic hepatitis C.

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PMID: 20515796

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Acute additive effect of montelukast and beclomethasone on AMP induced bronchoconstriction.

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Idiopathic pulmonary fibrosis: a disease with similarities and links to cancer biology.

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16,16-Dimethyl prostaglandin E2 efficacy on prevention and protection from bleomycin-induced lunginjury and fibrosis.

Failla M, Genovese T, Mazzon E, Fruciano M, Fagone E, Gili E, Barera A, La Rosa C, Conte E,Crimi N, Cuzzocrea S, Vancheri C.Am J Respir Cell Mol Biol. 2009 Jul;41(1):50-8. doi: 10.1165/rcmb.2007-0438OC. Epub 2008 Dec 4.

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International registry for idiopathic pulmonary fibrosis.

Guenther A, Eickelberg O, Preissner KT, Chambers R, Laurent G, Wells A, Crestani B, Vancheri C,Bonniaud P, Camus P, Schmitz G, Klepetko W, Schultze J, Vossmeyer D, Stumpf P.Thorax. 2008 Sep;63(9):841; author reply 841. No abstract available.

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Subsegmental pulmonary embolism: value of thoracic ultrasound for diagnosis and follow-up.

Mastruzzo C, Perracchio G, Poidomani G, Romano M, Crimi N,Vancheri C.Intern Med. 2008;47(15):1415-7. Epub 2008 Aug 1.


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Interleukin-6 receptor superantagonist Sant7 inhibits TGF-beta-induced proliferation of human lungfibroblasts.

Gallelli L, Falcone D, Pelaia G, Renda T, Terracciano R, Malara N, Vatrella A, Sanduzzi A,D'Agostino B, Rossi F, Vancheri C, Maselli R, Marsico SA, Savino R.Cell Prolif. 2008 Jun;41(3):393-407. doi: 10.1111/j.1365-2184.2008.00538.x. Epub 2008 Apr 24.

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TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition ofhuman lung fibroblasts into myofibroblasts.

Caraci F, Gili E, Calafiore M, Failla M, La Rosa C, Crimi N, Sortino MA, Nicoletti F, CopaniA, Vancheri C.Pharmacol Res. 2008 Apr;57(4):274-82. doi: 10.1016/j.phrs.2008.02.001. Epub 2008 Feb 9.

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A case of pulmonary Langerhans cell histiocytosis in a young woman with coeliac disease.

Mastruzzo C, Vancheri C, Li Mura D, Poletti V, Failla M, Crimi N.Swiss Med Wkly. 2007 Jun 2;137(21-22):326-7.


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CCR5 and CCR3 expression on T CD3+ lymphocytes from HIV/Leishmania co-infected subjects.

Nigro L, Rizzo ML, Vancheri C, La Rosa R, Mastruzzo C, Tomaselli V, Ragusa A, Manuele R,Cacopardo B.Med Microbiol Immunol. 2007 Dec;196(4):253-5. Epub 2007 Apr 25.

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Activation of cytosolic phospholipase A2 and 15-lipoxygenase by oxidized low-density lipoproteins incultured human lung fibroblasts.

Lupo G, Anfuso CD, Ragusa N, Tirolo C, Marchetti B, Gili E, La Rosa C, Vancheri C.Biochim Biophys Acta. 2007 Apr;1771(4):522-32. Epub 2007 Feb 4.

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Astrocyte-like cells as a main target for estrogen action during neuronal differentiation.

Merlo S, Calafiore M, Vancheri C, Luigi Canonico P, Copani A, Sortino MA.Mol Cell Neurosci. 2007 Apr;34(4):562-70. Epub 2006 Dec 28.

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Protective effect of orally administered carnosine on bleomycin-induced lung injury.

Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, LaRosa C, Crimi N, Rizzarelli E,Vancheri C.Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1095-104. Epub 2007 Jan 12.


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Exhaled bronchial cysteinyl leukotrienes in allergic patients.

Failla M, Crimi N, Vancheri C.Curr Opin Allergy Clin Immunol. 2007 Feb;7(1):25-31. Review.

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Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lunginjury.

Failla M, Genovese T, Mazzon E, Gili E, Muià C, Sortino M, Crimi N, Caputi AP, CuzzocreaS, Vancheri C.Respir Res. 2006 Nov 21;7:137.


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Effects of TGF-beta and glucocorticoids on map kinase phosphorylation, IL-6/IL-11 secretion andcell proliferation in primary cultures of human lung fibroblasts.

Pelaia G, Gallelli L, D'Agostino B, Vatrella A, Cuda G, Fratto D, Renda T, Galderisi U, Piegari E,Crimi N, Rossi F, Caputi M, Costanzo FS, Vancheri C, Maselli R, Marsico SA.J Cell Physiol. 2007 Feb;210(2):489-97.

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Altered intercellular communication in lung fibroblast cultures from patients with idiopathicpulmonary fibrosis.

Trovato-Salinaro A, Trovato-Salinaro E, Failla M, Mastruzzo C, Tomaselli V, Gili E, Crimi N,Condorelli DF, Vancheri C.Respir Res. 2006 Sep 27;7:122.


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Intranasal steroid reduces exhaled bronchial cysteinyl leukotrienes in allergic patients.

Failla M, Biondi G, Provvidenza Pistorio M, Gili E, Mastruzzo C,Vancheri C, Crimi N.Clin Exp Allergy. 2006 Mar;36(3):325-30.

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Cellular and molecular effects of protons: apoptosis induction and potential implications for cancertherapy.

Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U,Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G,Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M.Apoptosis. 2006 Jan;11(1):57-66.

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Bradykinin differentiates human lung fibroblasts to a myofibroblast phenotype via the B2 receptor.

Vancheri C, Gili E, Failla M, Mastruzzo C, Salinaro ET, Lofurno D, Pistorio MP, La Rosa C, CarusoM, Crimi N.J Allergy Clin Immunol. 2005 Dec;116(6):1242-8. Epub 2005 Nov 8.

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The p53-homologue p63 may promote thyroid cancer progression.

Malaguarnera R, Mandarino A, Mazzon E, Vella V, Gangemi P,Vancheri C, Vigneri P, Aloisi A,Vigneri R, Frasca F.


















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Endocr Relat Cancer. 2005 Dec;12(4):953-71.


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The effect of fexofenadine on expression of intercellular adhesion molecule 1 and induction ofapoptosis on peripheral eosinophils.

Vancheri C, Mastruzzo C, Tomaselli V, Bellistrì G, Pistorio MP, Greco LR, Salinaro ET, Failla M,Contrafatto MR, Crimi N.Allergy Asthma Proc. 2005 Jul-Aug;26(4):292-8.

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Interaction between human lung fibroblasts and T-lymphocytes prevents activation of CD4+ cells.

Vancheri C, Mastruzzo C, Trovato-Salinaro E, Gili E, Lo Furno D, Pistorio MP, Caruso M, La RosaC, Crimi C, Failla M, Crimi N.Respir Res. 2005 Sep 13;6:103.


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Endothelin-1 induces proliferation of human lung fibroblasts and IL-11 secretion through an ET(A)receptor-dependent activation of MAP kinases.

Gallelli L, Pelaia G, D'Agostino B, Cuda G, Vatrella A, Fratto D, Gioffrè V, Galderisi U, De Nardo M,Mastruzzo C, Salinaro ET, Maniscalco M, Sofia M, Crimi N, Rossi F, Caputi M, Costanzo FS, MaselliR, Marsico SA, Vancheri C.J Cell Biochem. 2005 Nov 1;96(4):858-68.

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Bradykinin and tachykinin-induced leukotriene release in airway virus infections.

Crimi N, Mastruzzo C, Vancheri C.Am J Respir Crit Care Med. 2005 Aug 15;172(4):511; author reply 511-2. No abstract available.

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Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to beta-amyloid.

Calafiore M, Battaglia G, Zappalà A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, SortinoMA, Nicoletti F, Copani A.Neurobiol Aging. 2006 Apr;27(4):606-13. Epub 2005 Jun 16.

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Inhibition or knock out of inducible nitric oxide synthase result in resistance to bleomycin-inducedlung injury.

Genovese T, Cuzzocrea S, Di Paola R, Failla M, Mazzon E, Sortino MA, Frasca G, Gili E, Crimi N,Caputi AP, Vancheri C.Respir Res. 2005 Jun 14;6:58.


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[Prevalence of respiratory symptoms, reduction in lung function and allergic sensitization in a groupof traffic police officers exposed to urban pollution].

Proietti L, Mastruzzo C, Palermo F, Vancheri C, Lisitano N, Crimi N.Med Lav. 2005 Jan-Feb;96(1):24-32. Italian.

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Montelukast protects against bradykinin-induced bronchospasm.

Crimi N, Mastruzzo C, Pagano C, Lisitano N, Palermo F, Vancheri C.J Allergy Clin Immunol. 2005 Apr;115(4):870-2. No abstract available.

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Effect of rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 on bleomycin-induced lung injury.

Genovese T, Cuzzocrea S, Di Paola R, Mazzon E, Mastruzzo C, Catalano P, Sortino M, Crimi N,Caputi AP, Thiemermann C,Vancheri C.Eur Respir J. 2005 Feb;25(2):225-34.


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Novel neuronal targets for the acetylcholinesterase inhibitor donepezil.

Sortino MA, Frasca G, Chisari M, Platania P, Chiechio S,Vancheri C, Copani A, Canonico PL.Neuropharmacology. 2004 Dec;47(8):1198-204.

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Resveratrol and propolis as necrosis or apoptosis inducers in human prostate carcinoma cells.

Scifo C, Cardile V, Russo A, Consoli R, Vancheri C, Capasso F, Vanella A, Renis M.Oncol Res. 2004;14(9):415-26.

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Effect of immunotherapy on asthma progression, BHR and sputum eosinophils in allergic rhinitis.

Polosa R, Li Gotti F, Mangano G, Paolino G, Mastruzzo C,Vancheri C, Lisitano N, Crimi N.Allergy. 2004 Nov;59(11):1224-8.

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A randomized, controlled study of specific immunotherapy in monosensitized subjects with seasonal




















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rhinitis: effect on bronchial hyperresponsiveness, sputum inflammatory markers and development ofasthma symptoms.

Crimi N, Li Gotti F, Mangano G, Paolino G, Mastruzzo C,Vancheri C, Lisitano N, Polosa R.Ann Ital Med Int. 2004 Apr-Jun;19(2):98-108.

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Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death.

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77.

78.

79.

80.

monocytes: implications for an altered immune response in pulmonary chronic inflammation.

Vancheri C, Mastruzzo C, Tomaselli V, Sortino MA, D'Amico L, Bellistrí G, Pistorio MP, Salinaro ET,Palermo F, Mistretta A, Crimi N.Am J Respir Cell Mol Biol. 2001 Nov;25(5):592-9.

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82.

83.

84.

85.

86.

87.

88.

Structural cells and extracellular matrix in chronic airways inflammation.

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102.

103.

104.

105.

106.

107.

108.

109.

Effect of theophylline on adenosine-induced bronchoconstriction.

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110.

111.

112.

113.

114.

115.

116.

117.

118.

Enhancing effect of dipyridamole inhalation on adenosine-induced bronchospasm in asthmaticpatients.

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119.

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89.

90.

91.

92.

93.

94.

95.

96.

97.

Crimi N, Mastruzzo C, Vancheri C.J Chemother. 1995 Aug;7(4):307-10. Review.

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98.

99.

100.

Tachyphylaxis to repeated challenges with inhaled adenosine in asthmatic subjects.

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102.

103.

104.

105.

106.

107.

108.

109.

Effect of theophylline on adenosine-induced bronchoconstriction.

Crimi N, Palermo F, Ciccarello C, Oliveri R, Vancheri C, Palermo B, Mistretta A.Ann Allergy. 1989 Feb;62(2):123-7. No abstract available.

PMID: 2919799

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Antigen-induced lung solute clearance in rats is dependent on capsaicin-sensitive nerves.

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PMID: 2643901

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Crimi N, Palermo F, Cacopardo B, Vancheri C, Oliveri R, Polosa R, Mistretta A.Ann Allergy. 1989 Jan;62(1):26-9.

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PMID: 2813982

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110.

111.

112.

113.

114.

115.

116.

117.

118.

Enhancing effect of dipyridamole inhalation on adenosine-induced bronchospasm in asthmaticpatients.

Crimi N, Palermo F, Oliveri R, Maccarrone C, Palermo B,Vancheri C, Polosa R, Mistretta A.Allergy. 1988 Apr;43(3):179-83.

PMID: 3377142

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PMID: 2466315

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PMID: 3438581

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PMID: 2951807


















119.

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