REGENERATIVE MEDICINE INTRODUCTION

Owes its inspiration to Greek mythology

and the Story of Prometheus and

Zeus: Greek myth says that

Zeus had Prometheus chained to a rock for

bringing fire to humans. Every day

an eagle would come and eat his liver. By the time the eagle

came back the next day, the liver had

grown back.http://commons.wikimedia.org/wiki/Image:Koeln_wrm_1044.jpg

THE END GOAL:

To create products that improve tissue function or heal tissue defects.Replace diseased or damaged tissue

Because……Donor tissues and organs are in short

supplyWe want to minimize immune system

response by using our own cells or novel ways to protect transplant.No need for anti-rejection medication, used in traditional transplants

Regenerative Medicine is the process

Definition:

Regenerative Medicine

REGENERATE, REPAIR AND REPLACE

Regenerate

REGENERATE, REPAIR AND REPLACE

Repair

REGENERATE, REPAIR AND REPLACE

Replace

Regenerative Medicine

in vitro approach: in vivo approach:

Research Methods

DISCUSSION QUESTION 1

Take 5-8 minutes to discuss the following question with the person next to you, & write down your responses:What kinds of information can we gain

from experiments in vivo?What kinds of information can we gain

from experiments in vitro?Why do you think we need to do research

in vivo, in a laboratory and outside of humans, instead of in vitro, inside of a person?

We will then discuss this as a class.

SCAFFOLDING

Various textures and materials to provide

Encourage cells to Allow to

pass to all cells Deliver and retain cells and

biochemical factors

GENE THERAPY

It is a technique for correcting defective genes that are responsible for disease development.

Gene therapy uses viruses to insert normal or desired genes into a patients cells.

FDA hasn’t approved any human gene therapy.

GENE THERAPY

CELL THERAPY

It is a technique in which cells from healthy patient or animal are injected into the unhealthy patient.

Idea is that healthy cells will tell unhealthy cells what they should do right, or trigger the body to destroy unhealthy cells allowing new ones to take their place.

FDA approved for

FDA does not approve of use of

TISSUE ENGINEERING

Grow entire tissues for patients.

Use scaffolding to provide structure for cells to grow and take their shape.

Implanted into patient, which then “learn” what to become based on

STEM CELLS

Non-specialized cells

Being placed into a specific place in the body, they can become the cells needed in the area.

Two types: Adult & Embryonic Use is debatable

ORGAN ENGINEERING

Not very far in development Grown

Use “skeleton” from dead organs,

Needs to complete complex metabolic functions

Require