Quick Reference Table Conclusion**** Review Explanation ... · Acacia Senegal Gum 1 up to 9% for...
Transcript of Quick Reference Table Conclusion**** Review Explanation ... · Acacia Senegal Gum 1 up to 9% for...
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
1,2-butanediol 1 not in use at the time* IJT 31 (S2): 147-168,2012
1,2-hexanediol 1 0.00005 to 10% IJT 31 (S2): 147-168,2012
1-Naphthol 1 up to 3% in haircoloring products
JACT 8(4):749-68,1989 confirmed
12/062,3-Naphthalenediol 1 JACT 7(3):353-57,
19882,4-Diaminophenol 1 0.2% as the free base JACT 13(5):330-43,
1994 confirmed06/09
2,4-Diaminophenol HCl (aka 2,4-DiaminophenolDihydrochloride)
1 0.2% as the free base JACT 13(5):330-43,1994 confirmed
06/092,4-Diaminophenoxyethanol HCl 1 up to 2% Final Amended
Report 12/07Available from CIRJACT 10(1):113-34,
1991 (original report)2,4-Diaminophenoxyethanol Sulfate (amended) 1 up to 2% Final Amended
Report 12/07Available from CIRJACT 10(1):113-34,
1991 (original report)2-Amino-3-Hydroxypyridine 1 Final report 09/2014
available from CIR2-Amino-3-Nitrophenol 1 up to 2% in hair dyes IJT 28(S3): 217-251,
20092-amino-4-hydroxyethylaminoanisole 1 should not be used in cosmetic
products where N-nitrosocompounds may be formed
IJT 32(S1):25-35,2013
2-amino-4-hydroxyethylaminoanisole sulfate 1 should not be used in cosmeticproducts where N-nitroso
compounds may be formed
IJT 32(S1):25-35,2013
2-Amino-4-Nitrophenol 1 concentration not reported * IJT 28(S3): 217-251,2009
2-Amino-4-Nitrophenol Sulfate 1 not in current use * IJT 28(S3): 217-251,2009
2-Amino-5-Nitrophenol 1 not in current use * IJT 28(S3): 217-251,2009
2-Amino-6-Chloro-4-Nitrophenol 1 up to 2% in hair dyes IJT16(S1):131-43,1997
2-Amino-6-Chloro-4-Nitrophenol HCl 1 up to 2% in hair dyes IJT16(S1):131-43,1997
2-Bromo-2-Nitropropane-1,3-Diol 1 0.1%; may contribute toendogenous nitrosamine
formation; but should not be
JACT 3(3):139-55,1984 (Addendum)JEPT 4(4):47-61,
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Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
used under circumstanceswhere its actions withamines or amides can
result in the formation ofnitrosamines or nitrosamides
1980 (Originalreport) confirmed09/03 IJT 25(S2),
2006
2-Chloro-p-Phenylenediamine 1 up to 0.1% JACT 11(4):521-530,1992
2-Chloro-p-Phenylenediamine Sulfate 1 up to 1.0% JACT 11(4):521-530,1992
2-Ethoxy Ethoxy Ethyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
2-Methyl-5-Hydroxyethylaminophenol 1 up to 5% JACT 9(2):185-202,1990 confirmed
08/062-Methyl Resorcinol 1 up to 2% JACT 5(3):167-
203, 1986 confirmed12/06
2-Nitro-p-Phenylenediamine 1 up to 1% JACT 4 (3):161-202,1985 confirmed
11/03 IJT 25(S2),2006
3-Methylamino-4-Nitrophenoxyethanol 1 up to 0.15% IJT 27 (S2): 41-51,2008
3-Nitro-p-Hydroxyethylaminophenol 1 up to 10% in hair coloringproducts (5% after dilution)
IJT 28(S3): 217-251,2009
4-Amino-2-Hydroxytoluene 1 up to 5% JACT 8 (4):569-87,1989 confirmed
04/064-Amino-2-Nitrophenol 1 IJT 28(S3): 217-251,
20094-Amino-3-Nitrophenol 1 up to 9% in hair dyes IJT 28(S3): 217-251,
20094-Amino-m-Cresol 1 up to 0.7% in oxidative and
non-oxidative hair dyesIJT 23(S2):1-22,
20044-Chloro-2-Aminophenol 1 1 Safe ase used in oxidative
hair dyes, but the availabledata are insufficient tosupport the safety in
non-oxidative hair dyes
IJT 23(S2):1-22,2004
4-Chlororesorcinol 1 1% in hair dyes JACT 15 (4): 284-94,1996
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Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
4-Hydroxypropylamino-3-Nitrophenol 1 up to 2.6% in hair dyes IJT 28(S3): 217-251,2009
4-Methoxy-m- Phenylenediamine 1 carcinogenicity JACT 11(4):381-422,1992
4-Methoxy-m-Phenylenediamine HCl 1 carcinogenicity JACT 11(4):381-422,1992
4-Methoxy-m-Phenylenediamine Sulfate 1 carcinogenicity JACT 11(4):381-422,1992
4-Nitro-m-Phenylenediamine 1 up to 0.2% JACT 4 (3):161-202,1985 confirmed
11/03 IJT 25(S2),2006
5-Amino-4-Chloro-o-Cresol 1 up to 2% in oxidative andnon-oxidative hair dyes
IJT 23(S2):1-22,2004
5-Amino-6-Chloro-o-Cresol 1 up to 2% in oxidative andnon-oxidative hair dyes
IJT 23(S2):1-22,2004
5-Bromo-5-Nitro-1,3-Dioxane 1 0.1%; but should not be usedunder circumstances where itsactions with amines or amidescan result in the formation ofnitrosamines or nitrosamides
JACT 9(2):279-88,1990
6-Amino-m-Cresol 1 up to 2.4% in oxidative andnon-oxidative hair dyes
IJT 23(S2):1-22,2004
6-Amino-o-Cresol 1 Safe as used (up to 0.7%) inoxidative hair dyes, but the
available data are insufficientto support the safety innon-oxidative hair dyes
IJT 23(S2):1-22,2004
6-Hydroxyindole 1 IJT 33(S3):24-35,2014
Acacia Catechu Gum 1 IJT 24(S3):75-118,2005
Acacia Concinna Fruit Extract 1 IJT 24(S3):75-118,2005
Acacia Dealbata Leaf Extract 1 IJT 24(S3):75-118,2005
Acacia Dealbata Leaf Wax 1 IJT 24(S3):75-118,2005
Acacia Decurrens Extract 1 IJT 24(S3):75-118,2005
Acacia Farnesiana Flower/Stem Extract 1 IJT 24 (S3):75-118,2005
Acacia Farnesiana Flower Wax 1 IJT 24(S3):75-118,2005
Acacia Farnesiana Gum 1 IJT 24(S3):75-118,2005
Acacia Senegal Extract 1 IJT 24(S3):75-118,2005
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Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Acacia Senegal Gum 1 up to 9% for the gum and0.001% for the extract
IJT 24(S3:75-118,2005
Acacia Senegal Gum Extract 1 up to 9% for the gum and0.001% for the extract
IJT 24(S3:75-118,2005
Acetamide MEA (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available
from CIR; JACT12(3):225-36, 1993
(original report); IJT30(Suppl. 2):73-127,
2011 (re-review)
Acetic Acid 1 0.0003 to 0.3% IJT 31(S4): 112- 136,2012
Acetyl arginine 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Acetylated Lanolin 1 up to 7% JEPT 4(4):63-92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Acetylated Lanolin Alcohol 1 up to 16% JEPT 4 (4):63-92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Acetyl Carnitine 1 safe when formulatedto be non- irritating
IJT 31(S3):296-341,2012
Acetyl Carnitine HCl 1 safe when formulatedto be non- irritating
IJT 31(S3):296-341,2012
Acetyl Cysteine 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Acetyl Glutamic acid 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Acetyl Glutamine 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Acetyl Histidine 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Acetyl Methionine 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Acetyl Proline 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Acetyl Tributyl Citrate 1 up to 7% IJT 21 (S2):1-17,2002
Acetyl Triethyl Citrate 1 up to 7% IJT 21 (S2):1-17,2002
Acetyl Trihexyl Citrate 1 not in current use * IJT 21(S2):1-17,2002
Acetyl Trioctyl Citrate 1 not in current use * IJT 21(S2):1-17,2002
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Acetyl Tyrosine 1 safe for use for cosmeticswhen formulated
to be non-irritating
Final report 12/2013available from CIR
Achillea Millefolium Extract 1 safe for use when formulatedto be non-sensitizing
IJT 20(S2):79-84,2001; final report12/2013 available
from CIRAchillea Millefolium Flower/Leaf/Stem Extract 1 safe for use when formulated
to be non-sensitizingFinal report 12/2013
available from CIRAchillea Millefolium Flower Extract 1 safe for use when formulated
to be non-sensitizingFinal report 12/2013
available from CIRAcid Orange 3 1 0.2% in hair dyes IJT 19 (S1):1-9, 2000Acid Violet 43 1 safe for use in hair dye
formulations when freeof impurities except forthe following: <=18%volatile matter (at 135
degrees C) and chloridesand sulfates (calculated
as sodium salts); <=0.4%water-insoluble matter;
<=0.2% 1-hydroxy-9,10-anthracenedione; <=0.2%
1,4-dihydroxy-9,10-anthracenedione; <=0.1%p-toluidine; <=0.2% p-toluidine sulfonic acids,
sodium salts; <=1% subsidiarycolors; <=20 ppm lead (asPb); <=3 ppm arsenic (as
As); <=1 ppm mercury (asHg); and >80% total color.
IJT 20(S3):1-6, 2001
Acrylamide/Ethyltrimonium Chloride* Acrylate/Ethalkonium Chloride Acrylate Copolymer
1 safe in the present practices ofuse and concentration, when
formulated to be non-irritating
IJT 31(S3): 296-341(2012)
Acrylamidopropyl Trimonium Chloride/AcrylamideCopolymer*
1 safe in the present practices ofuse and concentration, when
formulated to be non-irritating
IJT 31(S3): 296-341(2012)
Acrylamidopropyl-Trimonium Chloride/AcrylatesCopolymer
1 safe in the present practices ofuse and concentration, when
formulated to be non-irritating
IJT 31(S3): 296-341(2012)
Acrylates/Ammonium Methacrylate Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Acrylates/bis-hydroxypropyl dimethicone crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Acrylates/C12-13 Alkyl Methacrylates/MethoxyethylAcrylate Crosspolymer
1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Acrylates/dimethiconol acrylate copolymer 1 up to 0.5% Final report 12/10available from CIR
Acrylates/Ethylhexyl Acrylate/Glycidyl MethacrylateCrosspolymer
1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Acrylates/Ethylhexyl Acrylate/Styrene Copolymer 1 not in current use* Final report 09/2014available from CIR
Acrylates/Ethylhexyl Acrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Acrylates/Hydroxyesters Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Acrylates/PEG-4 Dimethacrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Acrylates/PVP Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Acrylates/Steareth-20 Methacrylate Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Acrylates/Steareth-20 Methacrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Acrylates/Steareth-50 Acrylate Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Acrylates/VA Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Acrylates/Vinyl Isodecanoate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Acrylates/Vinyl Neodecanoate Crosspolymer 1 Final report 11/2011available from CIR
Acrylates C10/30 Alkyl Acrylate Crosspolymer 1 1 when used as describedin assessment, 0.0002-5%
data does not support usewhen polymerized in benzene
Final report 11/2011available from CIR
Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Acrylates Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Actinidia Chinensis (Kiwi) Seed Oil 1 up to 0.1% Final report 03/11available from CIR
Adansonia Digitata Oil 1 up to 0.01% Final report 03/11available from CIR
Adansonia Digitata Seed Oil 1 not in current use* Final report 03/11available from CIR
Adansonia digitata seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
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Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Adipic Acid 1 0.000001% in leave-on; 18% in rinse- off
IJT 31 (S1):5-76,2012
Adipic acid/1,4 butanediol/terephthalate copolymer 1 not in current use* IJT 33(S3):36-47,2014
Adipic Acid Dihydrazide 1 JACT 13(3):154-6,1994
Alanine 1 3.0 x 10-7 to 0.1% IJT 32(S4):41-64,2013
Alcaligenes polysaccharides 1 0.005 to 0.3% Final report 09/12available from CIR
Alcohol Denat. denatured with Quassin or Brucine 1 IJT 27 (S1):1-43,2008
Alcohol Denat. denatured with t-Butyl Alcohol, DenatoniumBenzoate, Diethyl Phthalate, or Methyl Alcohol
1 up to 99% IJT 27 (S1):1-43,2008
Aldioxa 1 JACT 12(3):237-42,1993
Aleurites Moluccanus Bakoly Seed Oil 1 not in current use* Final report 03/11available from CIR
Aleurites Moluccanus Seed Oil 1 0.00001 to 5% Final report 03/11available from CIR
Alkyl aryl sulfonate hydrotropes 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 30(Suppl.3):270-283, 2011
Allantoin 1 up to 2% IJT 29(Suppl. 2):84-97, 2010
Allantoin Ascorbate 1 up to 0.05% IJT 29(Suppl. 2):84-97, 2010
Allantoin Biotin 1 not in current use * IJT 29(Suppl. 2):84-97, 2010
Allantoin Galacturonic Acid 1 not in current use * IJT 29(Suppl. 2):84-97, 2010
Allantoin Glycyrrhetinic Acid 1 concentration not reported * IJT 29(Suppl. 2):84-97, 2010
Allantoin Panthenol 1 concentration not reported * IJT 29(Suppl. 2):84-97, 2010
Allantoin Polygalacturonic Acid 1 concentration not reported * IJT 29(Suppl. 2):84-97, 2010
Allyl Methacrylate/Glycol Dimethacrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Allyl Methacrylates Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Almondamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
IJT 32(S1):36-58,2013
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
Almondamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Almondamidopropyl dimethylamine 1 not in current use* safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Almond oil PEG-6 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Almond oil PEG-8 Esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Almond Oil Propylene Glycol Esters* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
Aloe Andongensis Extract 1 IJT 26(S2):1-50,2007
Aloe Andongensis Leaf Juice 1 IJT 26(S2):1-50,2007
Aloe Arborescens Leaf Extract 1 IJT 26(S2):1-50,2007
Aloe Arborescens Leaf Juice 1 IJT 26(S2):1-50,2007
Aloe Arborescens Leaf Protoplasts 1 IJT 26(S2):1- 50,2007
Aloe Barbadensis Flower Extract 1 safe as cosmetic ingredientsin the practices of useand concentrations as
described in this safetyassessment, if anthraquinone
levels in the ingredientsdo not exceed 50 ppm.
IJT 26(S2):1-50,2007
Aloe Barbadensis Leaf 1 safe as cosmetic ingredientsin the practices of useand concentrations as
described in this safetyassessment, if anthraquinone
levels in the ingredientsdo not exceed 50 ppm.
IJT 26(S2):1- 50,2007
Aloe Barbadensis Leaf Extract 1 safe as cosmetic ingredientsin the practices of use
IJT 26(S2):1-50,2007
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Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
and concentrations asdescribed in this safety
assessment, if anthraquinonelevels in the ingredientsdo not exceed 50 ppm.
Aloe Barbadensis Leaf Juice 1 safe as cosmetic ingredientsin the practices of useand concentrations as
described in this safetyassessment, if anthraquinone
levels in the ingredientsdo not exceed 50 ppm.
IJT 26(S2):1-50,2007
Aloe Barbadensis Leaf Water 1 safe as cosmetic ingredientsin the practices of useand concentrations as
described in this safetyassessment, if anthraquinone
levels in the ingredientsdo not exceed 50 ppm.
IJT 26(S2):1-50,2007
Aloe Barbadensis Polysaccharides 1 safe as cosmetic ingredientsin the practices of useand concentrations as
described in this safetyassessment, if anthraquinone
levels in the ingredientsdo not exceed 50 ppm.
IJT 26(S2):1-50,2007
Aloe Ferox Leaf Extract 1 IJT 26(S2):1-50,2007
Aloe Ferox Leaf Juice 1 IJT 26(S2):1-50,2007
Aloe Ferox Leaf Juice Extract 1 IJT 26(S2):1-50,2007
Alpha Hydroxy Acids (e.g. Glycolic and Lactic Acid, andtheir salts and esters) (see CIR report of the same name)
Glycolic and Lactic Acid,their common salts and their
simple esters, are safe foruse in cosmetic products at
concentrations <=10%, at finalformulation pH >=3.5, when
formulated to avoid increasingsun sensitivity or when
directions for use include thedaily use of sun protection.These ingredients are safefor use in salon products atconcentrations <=30%, at
final formulation pH >=3.0,in products designed forbrief, discontinuous use
followed by thorough rinsing
IJT 17(S1):1-242,1998
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
from the skin, when appliedby trained professionals,and when application is
accompanied by directions forthe daily use of sun protection.
Alumina 1 Final report 12/2013available from CIR
Alumina Magnesium Metasilicate 1 up to 0.01% Final Report 09/09available from CIR
Aluminum Calcium Sodium Silicate 1 up to 6% Final Report 09/09available from CIR
Aluminum Citrate 1 concentration not reported * IJT 33 (S2): 16-46,2014
Aluminum Dimyristate (amended) 1 up to 3% IJT29(S3) :162-186,2010
Aluminum Distearate 1 up to 5% JACT 1(2):143-77, 1982 confirmed
11/01 IJT22(S1):1-35, 2003
Aluminum Hydroxide 1 Final report 12/2013available from CIR
Aluminum Iron Silicates 1 not in current use* Final Report 09/09available from CIR
Aluminum Isostearates/Myristates 1 not in current use * IJT29(S3) :162-186,2010
Aluminum Myristate 1 up to 1% IJT 29(S3) :162-186,2010
Aluminum Myristates/Palmitates 1 up to 6% IJT29(S3) :162-186,2010
Aluminum Silicate 1 up to 37% in dentifrices;up to 3% in other uses
IJT 22(S1):37-102,2003
Aluminum Starch Octenylsuccinate 1 safe as used provided thatestablished limitations
imposed on heavymetal concentrations
are not exceeded
IJT 21(S1):1-7, 2002
Aluminum Stearate 1 up to 8% JACT 1(2):143-77,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Aluminum Tristearate 1 up to 10% JACT 1(2):143 -77,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Amaranthus Hypochondriacus Seed Oil 1 not in current use* Final report 03/11available from CIR
Amino Bispropyl Dimethicone 1 not in current use * IJT 22(S2):11-35,2003
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Aminoethyl Propanediol 1 Final report 09/2013available from CIR
Aminomethyl Propanediol (amended) 1 up to 2% IJT 28 (S2):141-1612009 JACT
9(2):203-28, 1990(original report);
final report 09/2013available from CIR
Aminomethyl Propanol (amended) 1 up to 7% IJT 28 (S2):141-1612009 JACT
9(2):203-28, 1990(original report)
Aminopropyl Dimethicone 1 not in current use * IJT 22(S2):11-35,2003
Ammonium Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Ammonium Bisulfite 1 up to 32% IJT 22(S2):63- 88,2003
Ammonium C12-15 Pareth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT 29(Suppl.3) :151-161,2010
Ammonium Capryleth Sulfate, 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT 29(Suppl.3) :151-161,2010
Ammonium Cocomonoglyceride Sulfate (amended) 1 not in current use * IJT 30(S1):5S-16SAmmonium Coco-Sulfate 1 not in current use * IJT 29(S2): 115-132,
2010Ammonium Cocoyl Isethionate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRAmmonium Cocoyl Sarcosinate 1 safe as used in rinse-off
products; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Ammonium Cumenesulfonate 1 not in current use * IJT 30(S3):270-283,2011
Ammonium Dinonyl Sulfosuccinate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Ammonium Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 29 (S4) 288-305,2010
Ammonium Glycolate 1 safe for use in cosmeticproducts at concentrations
<=10%, at final formulationpH >=3.5, when formulated
IJT 17(S1):1-242,1998
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
to avoid increasing sunsensitivity or when directionsfor use include the daily use
of sun protection. Theseingredients are safe foruse in salon products at
concentrations <=30%, atfinal formulation pH >=3.0,
in products designed forbrief, discontinuous use
followed by thorough rinsingfrom the skin, when applied
by trained professionals,and when application is
accompanied by directions forthe daily use of sun protection.
Ammonium Glycyrrhizate 1 up to 5% IJT 26 (S2):79-112,2007
Ammonium Lactate 1 safe for use in cosmeticproducts at concentrations
<=10%, at final formulationpH >=3.5, when formulated
to avoid increasing sunsensitivity or when directionsfor use include the daily use
of sun protection. Theseingredients are safe foruse in salon products at
concentrations <=30%, atfinal formulation pH >=3.0,
in products designed forbrief, discontinuous use
followed by thorough rinsingfrom the skin, when applied
by trained professionals,and when application is
accompanied by directions forthe daily use of sun protection.
IJT 17(S1):1-242,1998
Ammonium Laureth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
JACT 2(5):1-34,1983 confirmed
11/02 IJT24(S1):85-89,
2005; IJT 29(Suppl.3) :151-161,2010
Ammonium Lauroyl Sarcosinate 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may be
IJT 20(S1):1-14,2001
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
formed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
Ammonium Lauryl Sulfate 1 safe for use in rinse-offproducts; but 1% for leave-on
JACT 2(7):127-81,1983 confirmed
06/02 IJT24(S1):89-98, 2005
Ammonium Myreth Sulfate 1 not in current use * safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Ammonium Myristyl Sulfate 1 not in current use * IJT 29(S2): 115-132,2010
Ammonium Persulfate 1 safe as oxidizing agentsin hair colorants and
lighteners designed forbrief, discontinuous usefollowed by thorough
rinsing from hair and skin
IJT 20(S3):7-21,2001
Ammonium Polyacrylate 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Ammonium Stearate 1 up to 10% JACT 1(2):143-77,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Ammonium Styrene/Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Ammonium Sulfite 1 not in current use * IJT 22 (S2):63-88,2003
Ammonium Tallate 1 not in current use * IJT 28(S3):252-258,2009
Ammonium Thioglycolate (amended) 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes
and colors; safe at 15.2%(as thioglycolic acid);
hairdressers should avoidskin contact and minimizeconsumer skin exposure
IJT 28(S3):68-133,2009 JACT
10(1):135-92, 1991(original report)
Ammonium VA/Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Ammonium Xylenesulfonate 1 up to 3% IJT 30 (S3):270-283,2011
Amodimethicone 1 up to 3% IJT 22(S2):11-35,2003
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Amodimethicone Hydroxystearate 1 not in current use * IJT 22(S2):11-35,2003
AMP-Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Amyl Acetate 1 up to 10% JACT 7(6):705-19,1988
Amyl Benzoate 1 not in current use * IJT 31 (S3):342-372(2012)
Anacardium Occidentale (Cashew) Seed Oil 1 0.002 to 1% Final report 03/11available from CIR
Anthemis nobilis flower extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Anthemis nobilis flower oil 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Anthemis nobilis flower powder 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Anthemis nobilis flower water 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Apricotamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Apricotamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Apricot Kernel Amino Acids 1 not in current use * IJT 33(S4):5-12,2014
Apricot Kernel Oil PEG-40 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Apricot Kernel Oil PEG-6 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Apricot Kernel Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Apricot Kernel Oil Propylene Glycol Esters* 1 safe when formulatedto be non-irritating
Final report 12/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Arachideth-20 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Arachidonic Acid 1 JACT 12(5):481-559,1993
Arachidyl behenate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
arachidyl erucate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Arachidyl Glucoside 1 safe in cosmeticswhen formulated
to be non- irritating
IJT 32 (S3): 22-48,2013
Arachidyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012
Arachidyl Propionate 1 up to 10% safe in cosmetics as longas they are formulated
to be non-irritating
JACT 9(2):143-52,1990 confirmed
06/06; Final report03/2013 available
from CIRArctium Lappa Seed Oil 1 not in use at the time* Final report 03/11
available from CIRArgania Spinosa Kernel Oil 1 0.001 to 10% Final report 03/11
available from CIRArgan oil PEG-8 esters 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014Arginine 1 0.00002 to 18% IJT 32(S4):41-64,
2013Arginine HCl 1 0.004 to 0.02% IJT 32(S4):41-64,
2013Arnica Montana 1 IJT 20(S2):1-11,
2001Arnica Montana Extract 1 IJT 20(S2):1-11,
2001Ascorbyl Dipalmitate 1 not in current use * IJT 18(S3):1-26,
1999Ascorbyl Palmitate 1 up to 0.2% IJT 18(S3):1- 26,
1999Ascorbyl Stearate 1 not in current use * IJT 18(S3):1-26,
1999Ascorbyl tocopheryl acetate 1 not in current use * Final report 03/2014
available from CIRAscorbyl tocopheryl maleate 1 Final report 03/2014
available from CIRAsparagine 1 concentration not reported IJT 32(S4):41-64,
2013Aspartic Acid 1 0.000005 to 1% IJT 32(S4):41-64,
2013
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Astragalus Gummifer Gum 1 up to 3% JACT 6(1):1 -22,1987 confirmed
09/04Astrocaryum Murumuru Seed Butter 1 0.001 to 7% Final report 03/11
available from CIRAttapulgite 1 up to 8% IJT 22(S1):37-102,
2003Avena Sativa (oat) bran 1 safe when formulated
to be non-sensitizingFinal report 12/2014
available from CIRAvena Sativa (oat) bran extract 1 safe when formulated
to be non-sensitizingFinal report 12/2014
available from CIRAvena Sativa (oat) Flower/leaf/stem Juice* 1 safe when formulated
to be non-sensitizingFinal report 12/2014
available from CIRAvena Sativa (oat) Kernel Extract 1 safe when formulated
to be non- sensitizingFinal report 12/2014
available from CIRAvena Sativa (oat) Kernel Flour 1 safe when formulated
to be non- sensitizingFinal report 12/2014
available from CIRAvena Sativa (oat) Kernel Meal 1 safe when formulated
to be non- sensitizingFinal report 12/2014
available from CIRAvena Sativa (Oat) Kernel Oil 1 0.01 to 3% Final report 03/11
available from CIRAvena Sativa (oat) Kernel Protein 1 safe when formulated
to be non- sensitizingFinal report 12/2014
available from CIRAvena Sativa (oat) Leaf/stalk Extract* 1 safe when formulated
to be non-sensitizingFinal report 12/2014
available from CIRAvena Sativa (oat) Leaf/stem Extract* 1 safe when formulated
to be non-sensitizingFinal report 12/2014
available from CIRAvena Sativa (oat) Leaf Extract 1 safe when formulated
to be non- sensitizingFinal report 12/2014
available from CIRAvena Sativa (oat) Meal Extract 1 safe when formulated
to be non- sensitizingFinal report 12/2014
available from CIRAvena Sativa (oat) Meristem Cell Extract 1 Final report 12/2014
available from CIRAvena Sativa (oat) Peptide 1 safe when formulated
to be non- sensitizingFinal report 12/2014
available from CIRAvena Sativa (oat) Protein Extract 1 safe when formulated
to be non- sensitizingFinal report 12/2014
available from CIRAvena Sativa (oat) Seed Extract* 1 safe when formulated
to be non- sensitizingFinal report 12/2014
available from CIRAvena Sativa (oat) Seed Water* 1 safe when formulated
to be non- sensitizingFinal report 12/2014
available from CIRAvena Sativa (oat) Sprout Oil* 1 safe when formulated
to be non- sensitizingFinal report 12/2014
available from CIRAvena Sativa (oat) Straw Extract 1 safe when formulated
to be non- sensitizingFinal report 12/2014
available from CIRAvocadamide DEA 1 safe in the present practices
of use and concentrationIJT 32(S1):36-58,
2013
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
Avocadamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Avocadamidopropyl dimethylamine 1 not in current use * safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Avocado Oil 1 0.0001 to 98% JEPT 4(4):93-103,1980 confirmed
06/01 IJT22(S1):1-35, 2003
Avocado oil PEG-11 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Avocado oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Avocado Oil Propylene Glycol Esters* 1 safe when formulatedto be non-irritating
Final report 12/2014available from CIR
Azelaic acid 1 up to 0.3% in leave-on;up to 10% in rinse- off
IJT 31 (S1):5-76,2012
Azelamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Azulene 1 IJT 18(S3):27-32,1999
Babassu Acid 1 not in current use* Final report 03/11available from CIR
Babassuamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
IJT 32(S1):36-58,2013
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
Babassuamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Babassuamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Babussuamidopropyl dimethylamine 1 not in current use* safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Barium Sulfate 1 safe in cosmetics as longas they are formulated
to be non-irritating
Final report 06/2014available from CIR
Basic Blue 99 1 up to 2% IJT 26(S2):51-63,2007
Basic Violet 1 1 IJT 28(S3):193-204.2009
Basic Violet 3 1 IJT 28(S3):193-204.2009
Basic Violet 4 1 IJT 28(S3):193-204.2009
Bassia Butyracea Seed Butter 1 not in current use* Final report 03/11available from CIR
Bassia Latifolia Seed Butter 1 0.001 to 2% Final report 03/11available from CIR
Batyl Alcohol 1 0.03 to 3% IJT 32 (S3): 5-21,2013
Batyl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Batyl Stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Beeswax 1 up to 56% JACT 3(3):1-41,1984 confirmed
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
06/03 IJT24(S1):48-52, 2005
Behenamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Behenamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Behenamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Behenamidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Beheneth-10 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Beheneth-15 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Beheneth-2 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Beheneth-20 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Beheneth-25 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Beheneth-30 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Beheneth-5 1 safe in cosmetics as longas they are formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Behenoxy Dimethicone 1 IJT 22(S2):11-35,2003; Final report12/2014 available
from CIRBehenoxy PEG-10 Dimethicone* 1 Final report 12/2014
available from CIRBehentrimonium chloride 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Behentrimonium methosulfate 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Behenyl/Isostearyl Beeswax 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRBehenyl Alcohol 1 up to 50% JACT 7(3):359-413,
1988 confirmed12/05
Behenyl Beeswax 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Behenyl Behenate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Behenyl Benzoate 1 not in current use* IJT 31 (S3):342-372(2012)
Behenyl Betaine 1 Up to 8.4% safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2014available from CIR
Behenyl dimethicone/bis-vinyldimethicone crosspolymer 1 0.005 to 10% IJT 33 (S2): 65-115,2014
Behenyl Erucate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Behenyl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Behenyl Olivate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Bentonite 1 12-80% in mud packs;up to 8% for other uses
IJT 22(S1):37-102,2003
Benzaldehyde 1 up to 0.5% IJT 25(S1):11- 27Benzalkonium Chloride 1 0.1% free active ingredient JACT 8(4):589-625,
1989 confirmed06/06
Benzethonium Chloride 1 0.5% skin; 0.02% eye area JACT 4(5):65-106,1985 confirmed
03/04 IJT 25(S2),2006
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Benzoic Acid 1 0.000002 to 5% Final amended report10/11; original IJT
20(S3):23-50, 2001Benzophenone-1 1 up to 2% JACT 2(5):35-77,
1983 confirmed09/02 IJT
24(S1):10-18, 2005Benzophenone-11 1 up to 0.2% JACT 2(5):79-84,
1983 confirmed09/02 IJT
24(S1):10-18, 2005Benzophenone-2 1 up to 6% JACT 2(5):79-84,
1983 confirmed09/02 IJT
24(S1):10-18, 2005Benzophenone-3 1 up to 7% JACT 2(5):35-77,
1983 confirmed09/02 IJT
24(S1):10-18, 2005Benzophenone-4 1 up to 2.5% JACT 2(5):79-84,
1983 confirmed09/02 IJT
24(S1):10-18, 2005Benzophenone-5 1 up to 0.3% JACT 2(5):35-77,
1983 confirmed09/02 IJT
24(S1):10-18, 2005Benzophenone-6 1 up to 0.3% JACT 2(5):35-77,
1983 confirmed09/02 IJT
24(S1):10-18, 2005Benzophenone-8 1 up to 0.2% JACT 2(5):79-84,
1983 confirmed09/02 IJT
24(S1):10-18, 2005Benzophenone-9 1 up to 0.4% JACT 2(5):79-84,
1983 confirmed09/02 IJT
24(S1):10-18, 2005Benzoxiquine 1 IJT 16(S1):117-
22,1997Benzyl Alcohol (amended) 1 0.000006 to 10% amended report 10/11
IJT 20(S3):23-50,2001 (original report)
Benzyl Benzoate 1 0.000005 to 4% Final report 10/11available from CIR
Benzylparaben (amended) 1 up to 0.4% if used alone;parabens mixture up to 0.8%
IJT 27(S4): 1-82,2008 JACT 5
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
(5):301-307, 1986(original report)
Bertholletia Excelsa Seed Oil 1 0.0003 to 0.5% Final report 03/11available from CIR
bertholletia excelsa seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Beta-glucan 1 0.000001 to 0.1% Final report 09/12available from CIR
Beta-glucan hydroxypropyltrimonium chloride 1 not in current use* Final report 09/12available from CIR
Beta-glucan palmitate 1 not in current use* Final report 09/12available from CIR
Betaine 1 0.0001 to 8.7% safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2014available from CIR
Beta-sitosterol 1 Final report 12/2013available from CIR
Beta-sitosteryl acetate 1 Final report 12/2013available from CIR
BHA 1 up to 0.2% JACT 3(5):83-146,1984
BHT 1 up to 0.5% IJT 21(S2):19-94,2002
Biosaccharide gum-1 1 0.002 to 6% Final report 09/12available from CIR
Biosaccharide gum-2 1 1% Final report 09/12available from CIR
Biosaccharide gum-3 1 not in current use* Final report 09/12available from CIR
Biosaccharide gum-4 1 0.00001 to 5% Final report 09/12available from CIR
Biosaccharide gum-5 1 not in current use* Final report 09/12available from CIR
Biotin 1 up to 1% IJT 20(S4):1-12,2001
Bis (tripeptide-1) copper acetate 1 not in current use* Final report 06/2014available from CIR
Bisabolol 1 up to 1% IJT 18(S3):33-40,1999
Bis-cetyl/PEG-8 Cetyl PEG-8 Dimethicone* 1 Final report 12/2014available from CIR
Bis-diglyceryl Polyacyladipate-1 1 0.2 to 10% IJT 32(S3):56-64,2013
Bis-diglyceryl Polyacyladipate-2 1 0.1 to 36% IJT 32(S3):56-64,2013
Bis-hydroxyethoxypropyl Dimethicone 1 Final report 12/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Bis-isobutyl PEG/PPG-10/7/dimethicone Copolymer* 1 Final report 12/2014available from CIR
Bis-isobutyl PEG-13/dimethicone Copolymer* 1 Final report 12/2014available from CIR
Bis-isobutyl PEG-24/PPG-7/dimethicone Copolymer* 1 Final report 12/2014available from CIR
Bis-PEG/PPG-14/14 Dimethicone 1 Final report 12/2014available from CIR
Bis-PEG/PPG-15/5 Dimethicone* 1 Final report 12/2014available from CIR
Bis-PEG/PPG-16/16 PEG/PPG-16/16 Dimethicone 1 Final report 12/2014available from CIR
Bis-PEG/PPG-18/6 Dimethicone* 1 Final report 12/2014available from CIR
Bis-PEG/PPG-20/20 Dimethicone 1 Final report 12/2014available from CIR
Bis-PEG/PPG-20/5 PEG/PPG-20/5 Dimethicone* 1 Final report 12/2014available from CIR
Bis-PEG-10 Dimethicone* 1 Final report 12/2014available from CIR
Bis-PEG-12 Dimethicone 1 Final report 12/2014available from CIR
Bis-PEG-12 Dimethicone Beeswax 1 Final report 12/2014available from CIR
Bis-PEG-12 Dimethicone Candelillate 1 Final report 12/2014available from CIR
Bis-PEG-15 Methyl Ether Dimethicone 1 Final report 12/2014available from CIR
Bis-PEG-1 Dimethicone* 1 Final report 12/2014available from CIR
Bis-PEG-20 Dimethicone* 1 Final report 12/2014available from CIR
Bis-PEG-4 Dimethicone 1 Final report 12/2014available from CIR
Bis-PEG-8 Dimethicone* 1 Final report 12/2014available from CIR
Bis-PEG-8 PEG-8 Dimethicone* 1 Final report 12/2014available from CIR
Bis-phenylisopropyl phenylisopropyl dimethicone/vinyldimethicone crosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Bis-stearoxy Dimethicone* 1 Final report 12/2014available from CIR
Bis-stearoxyethyl Dimethicone* 1 Final report 12/2014available from CIR
Bis-vinyldimethicone/bis-isobutyl PPG-20 crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Bis-vinyldimethicone/ PEG-10 dimethicone crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Bis-vinyldimethicone/PPG-20 crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Bis-vinyldimethicone crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Borage Seed Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Borago Officinalis Seed Oil 1 0.001 to 1% Final report 03/11available from CIR
Boric Acid 1 5%; but not safe for useon infant or injured skin
JACT 2(7):87-125,1983 confirmed
06/03Boron Nitride 1 Final report 06/13
available from CIRBrassica Campestris (Rapeseed) Sterols 1 Final report 12/2013
available from CIRBrassica Campestris (Rapeseeed) Oil Unsaponifiables 1 not in current use* Final report 03/11
available from CIRBrassica Campestris (Rapeseeed) Seed Oil 1 0.007 to 17% Final report 03/11
available from CIRBrassicamidopropyl dimethylamine 1 safe for use in cosmetics
when formulated to be non-irritating, which may bebased on a quantatitiverisk assessment (QRA)
Final report 06/2014available from CIR
Brassica Napus Seed Oil 1 not in current use* Final report 03/11available from CIR
Brassica Oleracea Acephala Seed Oil 1 not in current use* Final report 03/11available from CIR
Brassica Oleracea Italica (Broccoli) Seed Oil 1 0.001 to 3% Final report 03/11available from CIR
Brucine (denaturant) 1 IJT 27 (S1):1-43,2008
Brucine Sulfate (denaturant) 1 IJT 27 (S1):1-43,2008
Butoxyethanol 1 up to 10% in hairand nail products
JACT 15(6):462-526,1996 confirmed
02/02 IJT24(S1):18-20, 2005
Butoxyethyl Acetate 1 not in use at the time* IJT 31(S1):112-136,2012
Butyl Acetate 1 up to 72% JACT 8(4):681-705,1989 confirmed
08/06Butyl Acrylate/Glycol Dimethacrylate Crosspolymer 1 safe in the present practices of
use and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Butyl acrylate/styrene copolymer 1 Final report 09/2014available from CIR
Butylated Hydroxyanisole (now BHA) 0 up to 0.2% JACT 3(5):83-146,1984 confirmed
09/03 IJT 25(S2),2006
Butylated Hydroxytoluene (now BHT) 0 up to 0.5% IJT 21(S2):19-94,2002
Butyl Avocadate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Butyl Babassuate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Butyl Benzoate 1 not in use at the time* IJT 31(S3):342-372(2012)
Butyl Benzyl Phthalate 1 less than 1% JACT 11 (1):1-23,1992; IJT
30(S2):73-127, 2011Butyldimethicone methacrylate/methyl methacrylatecrosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Butylene/ethylene/styrene copolymer 1 Final report 09/2014available from CIR
Butylene Glycol 1 0.00007 to 89% JACT 4(5):223 -48,1985 confirmed
02/04 IJT 25(S2),2006
Butylene Glycol Cocoate 1 up to 2% IJT 30 (S1):5S-16S,2011
Butylene Glycol Diisononanoate 1 17% IJT 30 (S3):228-269,2011
Butyl Ester of PVM/MA Copolymer 1 up to 14% Amended FinalReport 06/09
Available from CIRJACT 12(3):243-56,
1993 (original report)Butyl Glucoside 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 32 (S3): 22-48,
2013Butyl Glycolate 1 safe for use in cosmetic
products at concentrations<=10%, at final formulationpH >=3.5, when formulated
to avoid increasing sunsensitivity or when directionsfor use include the daily use
of sun protection. Theseingredients are safe foruse in salon products at
concentrations <=30%, atfinal formulation pH >=3.0,
IJT 17(S1):1-242,1998
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
in products designed forbrief, discontinuous use
followed by thorough rinsingfrom the skin, when applied
by trained professionals,and when application is
accompanied by directions forthe daily use of sun protection.
Butyl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Butyl Lactate 1 safe for use in cosmeticproducts at concentrations
<=10%, at final formulationpH >=3.5, when formulated
to avoid increasing sunsensitivity or when directionsfor use include the daily use
of sun protection. Theseingredients are safe foruse in salon products at
concentrations <=30%, atfinal formulation pH >=3.0,
in products designed forbrief, discontinuous use
followed by thorough rinsingfrom the skin, when applied
by trained professionals,and when application is
accompanied by directions forthe daily use of sun protection.
IJT 17(S1):1-242,1998
Butyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Butyl Myristate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
amended IJT 29(S3):162-86, 2010;original JACT
9(2):247-58, 1990;final report 03/2013available from CIR
Butyloctyl Beeswax 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Butyloctyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Butyloctyl Benzoate 1 not in use at the time* IJT 31(S3):342-372(2012)
Butyloctyl Candelillate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Butyloctyl Cetearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Butyloctyl Oleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Butyloctyl Palmitate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Butyloctyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Butyl Oleate 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Butylparaben (amended) 1 up to 0.4% if used alone;parabens mixture up to 0.8%
IJT 27(S4): 1-82,2008 JACT
3(5):147-209, 1984(original report)
Butyl Stearate 1 up to 9% safe for use in cosmetics whenformulated to be non-irritating
JACT 4(5):107-46,1985 confirmed
06/03 IJT24(S1):21-25, 2005;final report 03/2013available from CIR
Butyl Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes
and colors; safe at 15.2%(as thioglycolic acid);
hairdressers should avoidskin contact and minimizeconsumer skin exposure
IJT 28(S3):68-133,2009
Butyrospermum Parkii (Shea) Butter 1 0.0005 to 60% Final report 03/11available from CIR
Butyrospermum Parkii (Shea) Butter Unsaponifiables 1 0.06 to 3% Final report 03/11available from CIR
Butyrospermum Parkii (Shea) Oil 1 0.01 to 15% Final report 03/11available from CIR
C10-11 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
C10-12 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C10-13 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C10-16 Alkyl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
C10-16 Pareth-1 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C10-16 Pareth-2 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C10-40 Isoalkyl acid Octododecanol Esters 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
C10-40 Isoalkyl acid phytosterol esters 1 Final report 12/2013available from CIR
C11-12 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C11-13 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C11-13 Pareth-10 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-13 Pareth-6 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-13 Pareth-9 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-14 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C11-15 Pareth-12 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-15 Pareth-15 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-15 Pareth-20 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-15 Pareth-3 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-15 Pareth-30 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-15 Pareth-40 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-15 Pareth-5 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-15 Pareth-7 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-15 Pareth-9 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-15 Sec-Pareth-12 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
C11-21 Pareth-10 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C11-21 Pareth-3 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 alkyl ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C12-13 Pareth-1 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-10 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-15 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-2 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-23 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-3 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-4 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-5 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-6 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-7 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-13 Pareth-9 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-14 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C12-14 Pareth-12 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-14 Pareth-3 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-14 Pareth-5 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-14 Pareth-7 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-14 Pareth-9 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-14 Sec-Pareth-12 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-15 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-20 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
C12-14 Sec-Pareth-3 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-30 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-40 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-5 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-50 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-7 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-8 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-14 Sec-Pareth-9 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244,2012
C12-15 Alkyl Benzoate 1 0.0008 to 59% IJT 31 (3):342-372(2012)
C12-15 alkyl ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C12-15 Alkyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
C12-15 Pareth-10 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-15 Pareth-11 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-15 Pareth-12 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-15 Pareth-2 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-15 Pareth-3 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-15 Pareth-5 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-15 Pareth-7 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-15 Pareth-9 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-16 Pareth-5 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-16 Pareth-7 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
C12-16 Pareth-9 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C12-18 Alkyl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
C12-20 Alkyl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
C12-20 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C13-14 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C13-15 Pareth-21 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C13-16 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C14-15 Pareth-11 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C14-15 Pareth-12 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C14-15 Pareth-13 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C14-15 Pareth-4 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C14-15 Pareth-7 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C14-15 Pareth-8 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C14-18 alkyl ethylhexanoate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C14-18 glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012
C14-30 Alkyl Beeswax 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C15-18 glycol 1 concentration not reported* IJT 31 (S2): 147-168,2013
C15-35 isoparaffin/isoalkylcycloalkanes 1 safe when formulatedto be non-irritating
IJT 31(S3): 269-295(2012)
C16-17 Alkyl Benzoate 1 not in current use * IJT 31(3):342-372(2012)
C16-22 Acid Amide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
C16-36 alkyl stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C18-22 hydroxyalkyl hydroxypropyl guar 1 not in current use* Final report 03/12available from CIR
C18-30 glycol 1 not in use at the time* IJT 31 (S2): 147-168,2014
C18-38 Alkyl Beeswax 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C18-38 Alkyl C24-54 Acid Ester 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C18-70 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C20-22 Alkyl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
C20-22 Alkyl phosphate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
C20-30 glycol 1 not in use at the time* IJT 31 (S2): 147-168,2015
C20-40 Alkyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C20-40 Alkyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C20-40 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C20-40 Pareth-95 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C22-24 Pareth-33 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C24-28 Alkyl Methicone 1 not in current use * IJT 22(S2):11-35,2003
C30-45 alkyl cetearyl dimethicone crosspolymer 1 0.2 to 4% IJT 33 (S2): 65-115,2014
C30-45 Alkyl Dimethicone 1 2% IJT 22(S2):11-35,2003
C30-45 alkyl dimethicone/ polycyclohexene oxidecrosspolymer
1 concentration not reported * IJT 33 (S2): 65-115,2014
C30-45 Alkyl Methicone 1 not in current use * IJT 22(S2):11-35,2003
C30-50 Alkyl Beeswax 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C30-50 Alkyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C30-50 Pareth-10 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C30-50 Pareth-3 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
C30-50 Pareth-40 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C32-36 Isoalkyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C40-60 Alkyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C40-60 Pareth-10 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C40-60 Pareth-3 and -10 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
C4-24 alkyl dimethicone/ divinyldimethicone crosspolymer 1 2% IJT 33 (S2): 65-115,2014
C4-5 Isoalkyl Cocoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
C4-6 Olefin/styrene copolymer 1 not in current use* Final report 09/2014available from CIR
C5-6 Olefin/styrene copolymer 1 not in current use* Final report 09/2014available from CIR
C7-8 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C8-10 alkyl ethyl phosphate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
C8-22 Alkyl Acrylates/Methacrylic Acid Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
C8-9 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C9-11 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C9-11 Pareth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
C9-11 Pareth-4 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
C9-11 Pareth-6 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
C9-11 Pareth-8 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
C9-12 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C9-13 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
C9-14 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
C9-15 alkyl phosphate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
C9-15 Pareth-8 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
C9-16 isoparaffin 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
Caesalpinia spinosa gum 1 0.002 to 0.5% Fina report 03/12available from CIR
Caesalpinia spinosa hydroxypropyltrimonium chloride 1 not in current use * Final report 03/12available from CIR
Calcium/Sodium PVM/MA Copolymer (amended) 1 concentration not reported * Amended FinalReport 06/09
Available from CIRJACT 12(3):243-56,
1993 (original report)Calcium Acetate 1 concentration not reported * IJT 31(S1):112-136,
2012Calcium Aluminum Borosilicate 1 0.001 to 33% IJT 32(S3): 65-72,
2013Calcium Ascorbate 1 not in current use * IJT 24(2):51-111,
2005Calcium Aspartate 1 not in current use * IJT 32(S4):41-64,
2013Calcium Benzoate 1 0.002 to 0.004% Amended final report
09/11 available fromCIR
Calcium Carboxymethyl Cellulose 1 not in use at the time* IJT 5 (3): 1-59, 1986(original report);Amended safety
assessment 03/09 -Available from CIR
Calcium citrate 1 not in use at the time* IJT 33 (S2): 16-46,2014
Calcium Disodium EDTA 1 not in current use * IJT 21(S2):95-142,2002
Calcium Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 29 (S4) 288-305,2010
Calcium Gluconate 1 Final report 03/2014available from CIR
Calcium Glycinate 1 3% IJT 32(S4):41-64,2013
Calcium Glycolate 1 Glycolic and Lactic Acid,their common salts and their
simple esters, are safe foruse in cosmetic products at
concentrations <=10%, at finalformulation pH >=3.5, when
IJT 17(S1):1-242,1998
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
formulated to avoid increasingsun sensitivity or when
directions for use include thedaily use of sun protection.These ingredients are safefor use in salon products atconcentrations <=30%, at
final formulation pH >=3.0,in products designed forbrief, discontinuous use
followed by thorough rinsingfrom the skin, when applied
by trained professionals,and when application is
accompanied by directions forthe daily use of sun protection.
Calcium Lactate 1 Glycolic and Lactic Acid,their common salts and their
simple esters, are safe foruse in cosmetic products at
concentrations <=10%, at finalformulation pH >=3.5, when
formulated to avoid increasingsun sensitivity or when
directions for use include thedaily use of sun protection.These ingredients are safefor use in salon products atconcentrations <=30%, at
final formulation pH >=3.0,in products designed forbrief, discontinuous use
followed by thorough rinsingfrom the skin, when applied
by trained professionals,and when application is
accompanied by directions forthe daily use of sun protection.
IJT 17(S1):1-242,1998
Calcium Myristate 1 not in use at the time* IJT29(S3) :162-186,2010
Calcium PCA 1 safe as used; shouldnot be used in cosmetic
products in which N-nitrosocompounds can be formed
Final report 12/2014available from CIR
Calcium Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,
IJT 22(3):1-108
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
directions for use include thedaily use of sun protection.
Calcium Silicate 1 up to 10% IJT 22(S1):37-102,2003
Calcium sodium borosilicate 1 0.0001 to 97% IJT 32(S3): 65-72,2013
Calcium Stearate 1 up to 23% JACT 1(2):143-77,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Calcium Thioglycolate 1 safe for use in hairstraighteners permanent
waves, tonics, dressings, andso forth, wave sets, other
noncoloring hair products,and hair dyes and colors, atconcentrations up to 15.2%;
hairdressers should avoidskin contact and minimizeconsumer skin exposure;safe for use in depilitories
when formulated to be non-irritating under conditions
of recommended use.
IJT 28(S3):68-133,2009
Calcium titanium borosilicate 1 6% IJT 32(S3): 65-72,2013
Calcium Xylenesulfonate 1 not in current use * IJT 30(S3):270-283,2011
Calendula Officinalis Extract (amended) 1 concentration not reported * IJT 20(S2):13-20,2001 (original
report); IJT 29 (S4):221-243, 2010
Calendula Officinalis Flower 1 concentration not reported * IJT 20(S2):13-20,2001 (original
report); IJT 29 (S4):221-243, 2010
Calendula Officinalis Flower Extract (amended) 1 up to 6% IJT 29 (S4): 221-243,2010
Calendula Officinalis Flower Oil (amended) 1 up to 0.1% IJT 29 (S4): 221-243,2010
Calendula Officinalis Seed Oil 1 concentration not reported * IJT 20(S2):13-20,2001 (original
report); IJT 29 (S4):221-243, 2010
Camellia Japonica Seed Oil 1 0.01 to 0.2% Final report 03/11available from CIR
Camellia Kissi Seed Oil 1 0.1 - 10% Final report 03/11available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Camellia Oleifera Seed Oil 1 0.003 to 3% Final report 03/11available from CIR
Camellia Sinensis Catechins 1 not in current use * safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 09/2014available from CIR
Camellia Sinensis Flower/Leaf/Stem Juice 1 Final report 09/2014available from CIR
Camellia Sinensis Flower Extract 1 Final report 09/2014available from CIR
Camellia Sinensis Leaf 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 09/2014available from CIR
Camellia Sinensis Leaf Extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 09/2014available from CIR
Camellia Sinensis Leaf Oil 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 09/2014available from CIR
Camellia Sinensis Leaf Powder 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 09/2014available from CIR
Camellia Sinensis Leaf Water 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 09/2014available from CIR
Camellia Sinensis Root Extract 1 Final report 09/2014available from CIR
Camellia Sinensis Seedcoat powder 1 Final report 09/2014available from CIR
Camellia Sinensis Seed extract 1 Final report 09/2014available from CIR
Camellia Sinensis Seed Oil 1 0.10% Final report 03/11available from CIR
Camellia Sinensis Seed Powder 1 Final report 09/2014available from CIR
Camellina Sativa Seed Oil 1 0.002 to 1% Final report 03/11available from CIR
Canarium Indicum Seed Oil 1 not in current use * Final report 03/11available from CIR
Candelilla Wax; now Euphorbia Cerifera (Candelilla) Wax 1 up to 27% JACT 3(3):1-41,1984 confirmed
06/03; IJT24(S1):1-102, 2005
Canolamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Canola Oil 1 0.0002 to 73% Final report 03/11available from CIR
Canola Oil Unsaponifiables 1 0.00% Final report 03/11available from CIR
Canola Sterols 1 Final report 12/2013available from CIR
Capramide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Capryl/capramidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Capryleth-4 1 safe in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Capryleth-5 1 safe in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Caprylic/Capric/Coco Glycerides (amended) 1 up to 4% IJT 30(S1):5S-16SCaprylic/Capric Triglyceride 1 up to 84% JEPT 4(4):105-20,
1980 confirmed06/01 IJT
22(S1):1-35, 2003Capryloyl Collagen Amino Acids 1 not in current use * safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRCapryloyl Glycine 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRCapryloyl Gold of Pleasure Amino Acids 1 not in current use * safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRCapryloyl Keratin Amino Acids 1 not in current use * safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRCapryloyl Pea Amino Acids 1 not in current use * safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRCapryloyl Quinoa Amino Acids 1 not in current use * safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRCapryloyl Salicylic Acid 1 safe when formulated to
avoid irritation and to avoidincreasing sun sensitivity,
IJT 22(S3):1-108,2003
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
Capryloyl Silk Amino Acids 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Caprylyl/capryl glucoside 1 safe in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
Caprylyl Butyrate 1 not in current use * safe in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Caprylyl Caprylate 1 safe in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Caprylyl Eicosenoate 1 safe in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Caprylyl Glucoside 1 safe in cosmeticswhen formulated
to be non- irritating
IJT 32 (S3): 22-48,2013
Caprylyl Glyceryl Ether 1 not in current use * IJT 32 (S3): 5-21,2013
Caprylyl Glycol 1 0.00003 to 5% IJT 31 (S2): 147-168,2012
Capsaicin 1 safe in the practices of useand concentration described in
the safety assessment, whenformulated not to be irritating
IJT 26(S1):3-106,2007
Capsicum Annuum Extract 1 safe in the practices of useand concentration described in
the safety assessment, whenformulated not to be irritating
IJT 26(S1):3-106,2007
Capsicum Annuum Fruit Extract 1 safe in the practices of useand concentration described in
the safety assessment, whenformulated not to be irritating
IJT 26(S1):3-106,2007
Capsicum Annuum Fruit Powder 1 safe in the practices of useand concentration described in
the safety assessment, whenformulated not to be irritating
IJT 26(S1):3-106,2007
Capsicum Annuum Resin 1 safe in the practices of useand concentration described in
the safety assessment, whenformulated not to be irritating
IJT 26(S1):3-106,2007
Capsicum Frutescens Fruit 1 safe in the practices of useand concentration described in
the safety assessment, whenformulated not to be irritating
IJT 26(S1):3-106,2007
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Capsicum Frutescens Fruit Extract 1 safe in the practices of useand concentration described in
the safety assessment, whenformulated not to be irritating
IJT 26(S1):3-106,2007
Capsicum Frutescens Resin 1 safe in the practices of useand concentration described in
the safety assessment, whenformulated not to be irritating
IJT 26(S1):3-106,2007
Captan 1 JACT 8(4):643-80,1989
Carbomer-910 1 not in current use * JACT 1(2)109-41, 1982
confirmed 11/02 IJT22(S1):1-35, 2003
Carbomer-934, -934P, -940, -941 1 up to 2% JACT 1(2)109-41,1982 confirmed
11/02 IJT22(S1):1-35, 2003
Carbomer-934P 1 up to 2% JACT 1(2)109-41,1982 confirmed
11/02 IJT22(S1):1-35, 2003
Carbomer-940 1 up to 2% JACT 1(2)109-41,1982 confirmed
11/02 IJT22(S1):1-35, 2003
Carbomer-941 1 up to 2% JACT 1(2)109-41,1982 confirmed
11/02 IJT22(S1):1-35, 2003
Carbomer-962 1 not in current use * JACT 1(2)109-41, 1982
confirmed 11/02 IJT22(S1):1-35, 2003
Carboxymethyl Dextran 1 not in current use * Tentative report06/12 available from
CIRCarboxymethyl Hydroxyethylcellulose 1 up to 3% Amended safety
assessment 03/09 -Available from CIR
Carboxymethyl hydroxypropyl guar 1 not in current use * Final report 09/12available from CIR
Carica Papaya Seed Oil 1 0.10% Final report 03/11available from CIR
Carnauba (Copernicia Cerifera) Wax 0 up to 20% JACT 3(3):1-41,1984 confirmed
06/03; IJT24(S1):1-102, 2005
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Carnitine 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Carnitine HCl 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Carnitine hydroxycitrate 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Carnitine PCA 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Carthamus Tinctorius (Safflower) Seed Oil 1 up to 84% in 2004 JACT 4(5):171-97,1985 confirmed
02/04; IJT25(S2) :1-89,2006;Final report 03/11
available from CIRCarvacrol 1 up to 0.5% IJT 25(S1):29-127,
2006Carya Illinoensis (Pecan) Seed Oil 1 not in current use * Final report 03/11
available from CIRCaryocar Brasiliense Fruit Oil 1 0.0005 to 0.2% Final report 03/11
available from CIRCassia Gum 1 not in current use * Final report 03/12
available from CIRCassia hydroxypropyltrimonium chloride 1 0.06 to 0.4% in rinse- off Final report 03/2012Castor oil phosphate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIRCellobiose octanonanoate 1 not in current use * IJT 30(S3):228-269,
2011Cellulose (amended) 1 up to 88% Amended safety
assessment 03/09 -Available from CIR
Cellulose Acetate (amended) 1 up to 2% Amended safetyassessment 03/09 -
Available from CIRCellulose Acetate Butyrate (amended) 1 up to 17% Amended safety
assessment 03/09 -Available from CIR
Cellulose Acetate Propionate 1 not in use at the time* Amended safetyassessment 03/09 -
Available from CIRCellulose Gum (amended) 1 up to 20% Amended safety
assessment 03/09 -Available from CIR
JACT 5(3):1-59,1986 (original report)
Cellulose Succinate 1 not in use at the time* Amended safetyassessment 03/09 -
Available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Ceratonia siliqua gum 1 0.0003 to 0.07% Final report 03/12available from CIR
Ceresin 1 up to 20% JACT 3(3):43-99,1984 confirmed
06/03 IJT24(S1):67-74, 2005
Ceteareth-10 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-100 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-11 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-12 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-13 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-14 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-15 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-16 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-17 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-18 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Ceteareth-2 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-20 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-23 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-24 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-25 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-27 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-28 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-29 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-3 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-30 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-33 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-34 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Ceteareth-4 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-40 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-5 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-50 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-55 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-6 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-60 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-7 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-8 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-80 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteareth-9 1 Safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S3):41-49,1999; IJT
31(S2):169-244(2012)
Ceteartrimonium chloride 1 safe in the present practices ofuse and concentration, when
formulated to be non-irritating
IJT 31(S3): 296-341(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Cetearyl Alcohol 1 up to 25% JACT 7(3):359-413,1988 confirmed
12/05Cetearyl Behenate 1 not in current use * safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRCetearyl Candelillate Final report 03/2013
available from CIRCetearyl dimethicone/vinyl dimethicone crosspolymer 1 0.001 to 0.005% IJT 33 (S2): 65-115,
2014Cetearyl dimethicone crosspolymer 1 00.002 to 23% IJT 33 (S2): 65-115,
2014Cetearyl ethylhexanoate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRCetearyl glucoside 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 32 (S3): 22-48,
2013Cetearyl Isononanoate 1 up to 50% safe for use in cosmetics when
formulated to be non-irritatingIJT 30(S3):228-269,
2011; Final Report03/2013 available
from CIRCetearyl Methicone 1 up to 1% IJT 22(S2):11-35,
2003Cetearyl Nonanoate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingIJT 30(S3):228-269,
2011; Final Report03/2013 available
from CIRCetearyl Octanoate (aka Cetearyl Ethylhexanoate) 1 up to 25% JACT 1(4):81-92,
1982 confirmed06/03 IJT 25(S2),
2006Cetearyl Olivate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal Report 03/2013
available from CIRCetearyl Palmate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal Report 03/2013
available from CIRCetearyl Palmitate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal Report 03/2013
available from CIRCetearyl Phosphate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIRCetearyl Rice Branate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal Report 03/2013
available from CIRCetearyl Stearate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal Report 03/2013
available from CIRCeteth-1 1 safe for use in cosmetics
when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
IJT 18(2):1-8, 1999(original report)
Ceteth-12 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-13 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-14 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-15 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-150 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-16 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-17 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-18 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-2 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-20 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-23 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Ceteth-24 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-25 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-30 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-4 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-40 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-45 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-6 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Ceteth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(Suppl.2):169-244, 2012;
IJT 18(2):1-8, 1999(original report)
Cetethyl Morpholinium Ethosulfate 1 IJT 20(S3):99 -102,2001
Cetoleth-10 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-11 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-15 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Cetoleth-18 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-2 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-20 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-22 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-24 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-25 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-30 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-4 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-5 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetoleth-6 1 safe as used when formulatedto be non- irritating
IJT 31(Suppl.2):169-244, 2012
Cetrimonium Bromide 1 safe as used when formulatedto be non- irritating
IJT16(S3):195-220,1997
(original report);IJT 31(S3): 296-341
(2012)Cetrimonium Chloride 1 safe as used when formulated
to be non- irritatingIJT
16(S3):195-220,1997(original report);
IJT 31(S3): 296-341(2012)
Cetrimonium methosulfate 1 safe as used when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Cetyl Acetate 1 0.01 to 17% IJT 31(S1):112-136,2012
Cetyl Alcohol 1 up to 50% JACT 7(3):359-413,1988 confirmed
12/05Cetyl Babassuate 1 Safe as used in cosmetics
when formulatedto be non-irritating
Final Report 03/2013available from CIR
Cetyl Behenate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final Report 03/2013available from CIR
Cetyl Betaine 1 0.36 to 7.4% Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Cetyl Caprate 1 Safe as used in cosmeticswhen formulated
to be non- irritating
Final Report 03/2013available from CIR
Cetyl Caprylate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Safe as used incosmetics when
formulated to be non-irritating
Cetyl Dimethicone 1 up to 10% IJT 22(S2):11-35,2003
Cetyl dimethicone/bis-vinyldimethicone crosspolymer 1 0.001 to 0.005% IJT 33 (S2): 65-115,2014
Cetyl Dimethyloctanoate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Safe as used incosmetics when
formulated to be non-irritating
Cetyl Esters 1 up to 7% Safe as used in cosmeticswhen formulated
to be non-irritating
IJT16(S1):123-30,1997;final report 03/2013available from CIR
Cetyl ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Cetyl Glyceryl Ether/ Chimyl Alcohol 1 IJT 32 (S3): 5-21,2013
Cetyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012
Cetyl hexacosyl dimethicone/bis-vinyldimethiconecrosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Cetyl Hydroxyethylcellulose (amended) 1 up to 2% Amended safetyassessment 03/09 -
Available from CIRCetyl isononanoate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingIJT 30(S3):228-269,
2011; Final Report03/2013 available
from CIRCetyl Lactate (Amended) 1 safe for use in cosmetic
products at concentrations<=10%, at final formulationpH >=3.5, when formulated
to avoid increasing sunsensitivity or when directionsfor use include the daily use
of sun protection. Theseingredients are safe foruse in salon products at
concentrations <=30%, atfinal formulation pH >=3.0,
in products designed forbrief, discontinuous use
IJT 17(S1):1-242,1998 JACT
1(2):97-107, 1982(Original Report)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
followed by thorough rinsingfrom the skin, when applied
by trained professionals,and when application is
accompanied by directions forthe daily use of sun protection.
Cetyl Laurate 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final Report 03/2013available from CIR
Cetyl Myristate 1 up to 6% safe for use in cosmetics whenformulated to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Cetyl Myristoleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final Report 03/2013available from CIR
Cetyl Oleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final Report 03/2013available from CIR
Cetyl Palmitate 1 up to 11% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(2):13-35,1982 confirmed
09/01 IJT24(S1):28-32, 2005;final report 03/2013available from CIR
Cetyl PEG/PPG-10/1 Dimethicone 1 Final report 12/2014available from CIR
Cetyl PEG/PPG-15/15 Butyl Ether Dimethicone* 1 Final report 12/2014available from CIR
Cetyl PEG/PPG-7/3 Dimethicone* 1 Final report 12/2014available from CIR
Cetyl PEG-8 Dimethicone* 1 Final report 12/2014available from CIR
Cetyl Phosphate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Cetyl Ricinoleate 1 up to 10% safe for use in cosmetics whenformulated to be non-irritating
IJT 26(S3): 31-77,2007; final report03/2013 available
from CIRCetyl Stearate 1 up to 15% safe for use in cosmetics when
formulated to be non-irritatingJACT 4(5):107-46,
1985 confirmed06/03 IJT
24(S1):21-25, 2005;final report 03/2013available from CIR
Cetyl Tallowate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Chamomilla recutita (matricaria) extract 1 Final report 12/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Chamomilla recutita (matricaria) flower 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Chamomilla recutita (matricaria) flower/leaf/stem extract 1 Final report 12/2013available from CIR
Chamomilla recutita (matricaria) flower/leaf/stem water 1 Final report 12/2013available from CIR
Chamomilla recutita (matricaria) flower/leaf extract 1 Final report 12/2013available from CIR
Chamomilla recutita (matricaria) flower extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Chamomilla recutita (matricaria) flower oil 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Chamomilla recutita (matricaria) flower powder 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Chamomilla recutita (matricaria) flower water 1 safe for use in cosmeticswhen formulated tobe non-sensitizing
Final report 12/2013available from CIR
Chamomilla recutita (matricaria) leaf extract 1 Final report 12/2013available from CIR
Chamomilla recutita (matricaria) oil 1 Final report 12/2013available from CIR
Chenopodium Quinoa Seed Oil 1 0.30% Final report 03/11available from CIR
Chimyl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Chimyl Stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Chlorhexidine 1 up to .14% JACT 12(3):201-23,1993 IJT 18(2):69,
1999 (Note)Chlorhexidine Diacetate 1 up to .19% JACT 12 (3):201-23,
1993 IJT 18(2):69,1999 (Note)
Chlorhexidine Digluconate 1 up to .20% JACT 12 (3):201-23,1993 IJT 18(2):69,
1999 (Note)Chlorhexidine Dihydrochloride 1 up to .16% JACT 12(3):201-23,
1993 IJT 18(2):69,1999 (Note)
Chloroacetamide 1 sensitization JACT 10(1):21- 32,1991
Chlorophene 1 IJT 23(S1):1-27 2004Chlorothymol (amended) 1 up to 0.5% IJT 25 (S1):29-127,
2006
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Chloroxylenol 1 up to 0.5% JACT 4(5):147-69,1985 confirmed
02/04 IJT 25(S2),2006
Chlorphenesin 1 0.000008 to 0.32% IJT 33 (2): 5-15,2014
Cholesterol 1 up to 3% JACT 5(5):491-516,1986 confirmed12/04
IJT 25(S2), 2006Cholesteryl Nonanoate 1 up to 30% IJT 30 (S3):228-269,
2011Choleth-24 1 up to 1.3% JACT 1(4):119-26,
1982 confirmed06/02 IJT
24(S1):32-34, 2005Choline chloride 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Citric acid 1 0.0000005 to 39% IJT 33 (S2): 16 -46,
2014Citrullus Lanatus (Watermelon) Seed Oil 1 2% Final report 03/11
available from CIRCitrus Aurantifolia (Lime) Seed Oil 1 not in current use* safe for use in cosmetic
products when finishedproducts, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 03/11available from CIR;Final report 09/2014
available from CIR
Citrus Aurantifolia (Lime) Seed Oil Unsaponifiables 1 not in current use* Final report 03/11available from CIR
Citrus Aurantium Amara (Bitter orange) peel oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Aurantium Currassuviensis Peel Oil 1 not in current use* safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and when
Final report 09/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
formulated to be non-sensitizing and non-irritating.
Citrus Aurantium Dulcis (Orange) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Aurantium Dulcis (Orange) Seed Oil 1 not in current use* Final report 03/11available from CIR
Citrus Aurantium Dulcis (Orange) Seed Oil Unsaponifiables 1 not in current use* Final report 03/11available from CIR
Citrus Clementina peel oil 1 not in current use* safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Grandis (Grapefruit) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Grandis (Grapefruit) Seed Oil 1 not in current use* Final report 03/11available from CIR
Citrus Grandis (Grapefruit) Seed Oil Unsaponifiables 1 not in current use* Final report 03/11available from CIR
Citrus Iyo Peel Oil 1 not in current use* safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Junos Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-
Final report 09/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
off products, do not containmore than 0.0015% (15
ppm) 5-methyoxypsoralen(5-MOP), and when
formulated to be non-sensitizing and non-irritating.
Citrus Limon (Lemon) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Limon (Lemon) Seed Oil 1 6% Final report 03/11available from CIR
Citrus Medica Vulgaris Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Nobilis (Mandarin Orange) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Paradisi (Grapefruit) Seed Oil 1 0.01 to 20% Final report 03/11available from CIR
Citrus Reticulata (Tangerine) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Citrus Tachibana/Reticulata Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-
Final report 09/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
off products, do not containmore than 0.0015% (15
ppm) 5-methyoxypsoralen(5-MOP), and when
formulated to be non-sensitizing and non-irritating.
Citrus Tangerina (Tangerine) Peel Oil 1 safe for use in cosmeticproducts when finished
products, excluding rinse-off products, do not contain
more than 0.0015% (15ppm) 5-methyoxypsoralen
(5-MOP), and whenformulated to be non-
sensitizing and non-irritating.
Final report 09/2014available from CIR
Coal Tar 1 IJT 27(S2):1-24,2008
Cocamide DEA (Amended) 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Cocamide MEA (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available fromCIR; IJT 18(2):9-16,
1999 (original report)
Cocamide methyl MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available fromCIR; IJT 18(2):9-16,
1999 (original report)
Cocamidopropylamine Oxide 1 safe for use in rinse-offs(up to 4%); insufficient
data for leave-ons
IJT 27(S1): 55-62,2008 IJT 19(2):1-5,
2000 (original report)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Cocamidopropyl betainamide MEA chloride 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Cocamidopropyl Betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
JACT 10(1):33-52,1991; IJT
31(S1):77-111, 2012
Cocamidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Coceth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-20 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-25 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-6 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coceth-8 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Coco/oleamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
JACT 10(1):33-52,1991; IJT
31(S1):77-111, 2012
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Coco/sunfloweramidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
JACT 10(1):33-52,1991; IJT
31(S1):77-111, 2012
Cocoamphoacetate 1 up to 6% JACT 9(2):121-42,1990 confirmed
04/06Cocoamphodiacetate 1 up to 12% JACT 9(2):121-
42, 1990 confirmed04/06
Cocoamphodipropionate 1 up to 15% JACT 9 (2):121-42,1990 confirmed
04/06Cocoamphopropionate 1 up to 10% JACT 9(2):121-
42, 1990 confirmed04/06
Coco-betaine 1 0.53 to 9.8% safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2014available from CIR
Coco-Caprylate 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Coco-Caprylate/Caprate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Coco-glucoside 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 32 (S3): 22-48,2013
Cocoglycerides (amended) 1 up to 14% IJT 30 (S1):5S-16SCoconut Acid (amended) 1 up to 14% in 2011 JACT 5(3):103-21,
1986 (originalreport); IJT 30 (s1):
5s-16s, 2011; alsoincluded in the Plant
Derived Fatty AcidOils report 03/11
Coconut Alcohol (amended) 1 up to 0.9% IJT 30 (S1):5S-16S,2011
Coconut Oil Decyl Esters (amended) 1 not in current use1 IJT 30(S1):5S-16S,2011
Coconut Oil PEG-10 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Coco-Rapeseedate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Cocos Nucifera (Coconut) Oil (amended) 1 up to 80% in 2011 JACT 5(3):103-21,1986 (original
report); IJT 30 (s1):5s-16s, 2011; also
included in the Plant
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Derived Fatty AcidOils report 03/11
Cocos Nucifera (Coconut) Seed Butter 1 not in current use* Final report 03/11available from CIR
Cocotrimonium chloride 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Cocotrimonium methosulfate 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Cocoylcholine methosulfate 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Cocoyl glutamic acid 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Cocoyl Sarcosine 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Coix Lacryma-Jobi (Job's Tears) Seed Oil 1 not in current use* Final report 03/11available from CIR
Collagen Amino Acids 1 IJT 33(S4):5-12,2014
Collodion 1 Final report 06/13available from CIR
Copernicia Cerifera (Carnauba) Wax 1 up to 20% JACT 3(3):1-41,1984 confirmed
06/03 IJT24(S1):48-52, 2005
Copper citrate 1 not in current use* IJT 33 (S2): 16-46,2014
Copper tripeptide-1 1 Final report 06/2014available from CIR
Corn Acid 1 not in current use* IJT 30(S1):17- 39,2011; final report
03/11 available fromCIR
Cornamide/cocamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
IJT 32(S1):36-58,2013
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
products in which N-nitrosocompounds may be formed
Cornamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Corn Gluten Amino Acids 1 not in current use* IJT 33(S4):5-12,2014
Corn Glycerides 1 not in current use* Final Report 09/08available from CIR
Corn Oil PEG-6 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Corn Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Corylus Americana (Hazelnut) Leaf Extract 1 IJT 20(S1):15-20,2001
Corylus Americana (Hazelnut) Seed Extract 1 IJT 20(S1):15-20,2001
Corylus Americana (Hazelnut) Seed Oil 1 IJT 20(S1):15-20,2001; Final report
03/11 available fromCIR
Corylus Avellana (Hazelnut) Leaf Extract 1 IJT 20(S1):15-20,2001
Corylus Avellana (Hazelnut) Seed Extract 1 IJT 20(S1):15-20,2001
Corylus Avellana (Hazelnut) Seed Oil 1 0.005 to 98% IJT 20(S1):15-20,2001; Final report
03/11 available fromCIR
Corylus Rostrata (Hazelnut) Leaf Extract 1 IJT 20(S1):15-20,2001
Corylus Rostrata (Hazelnut) Seed Extract 1 IJT 20(S1):15-20,2001
Cottonseed Acid 1 not in current use* IJT 20 (S2):21-29,2001; Final amended
report 03/11 availablefrom CIR
Cottonseed Glyceride 1 safe as used in cosmeticproducts, provided that
established and imposed limits
IJT 20(S2):21-29,2001
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
on gossypol, heavy metals,and pesticide concentrations
are not exceededCrambe Abyssinica Seed Oil 1 concentration not reported* Final report 03/11
available from CIRCrotonic acid/vinyl C8-12 isoalkyl esters/VA/bis-vinyldimethicone crosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Cucumis Sativus (Cucumber) Extract 1 0.0002 to 0.003% IJT 33 (2): 47-64,2014
Cucumis Sativus (Cucumber) Fruit 1 concentration not reported* IJT 33 (2): 47-64,2014
Cucumis Sativus (Cucumber) Fruit Extract 1 0.0000001 to 1% IJT 33 (2): 47-64,2014
Cucumis Sativus (Cucumber) Fruit Water 1 0.05 to 3% IJT 33 (2): 47-64,2014
Cucumis Sativus (Cucumber) Juice 1 concentration not reported* IJT 33 (2): 47-64,2014
Cucumis Sativus (Cucumber) Seed Extract 1 0.01 to 0.08% IJT 33 (2): 47-64,2014
Cucumis Sativus (Cucumber) Seed Oil 1 concentration not reported* Final report 03/2011available from CIR
Cucurbita Pepo (Pumpkin) Seed Oil 1 0.003 to 0.1% Final report 03/2011available from CIR
Cupuassauamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Cyamopsis tetragonoloba (guar) gum 1 0.02 to 1% in leave-on;0.09 to 5% in rinse-off
Final report 03/12available from CIR
Cycloheptasiloxane (amended) 1 not reported * IJT 30(S3):149-227,2011
Cyclohexasiloxane(amended) 1 up to 48% IJT 30 (S3):149-227,2011
Cyclohexyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Cyclomethicone (amended) 1 up to 89% JACT 10 (1):9-19,1991 (original
report); IJT30(S3):149-227, 2011
Cyclopentasiloxane (amended) 1 up to 93% IJT 30(S3):149-227,2011
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Cyclotetrasiloxane (amended) 1 up to 28% IJT 30(S3):149-227,2011
Cynara Cardunculus Seed Oil 1 not in current use* Final report 03/11available from CIR
Cysteine 1 0.0001 to 5% IJT 32(S4):41-64,2013
Cysteine HCl 1 0.0001 to 6% IJT 32(S4):41-64,2013
Cystine 1 0.001 to 3% IJT 32(S4):41-64,2013
DEA-C12-13 Alkyl Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-C12-13 Pareth Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-C12-15 Alkyl Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-Cetyl Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-Cocamphodipropionate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-Dodecylbenzenesulfonate (amended) 1 safe in the present practicesof use and concentrationwhen formulated to be
IJT 29 (S4): 288-305,2010 - Final amended
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
non-irritating, exceptdo not use in cosmetic
products in which N-nitrosocompounds can be formed
report 09/11 availablefrom CIR
DEA-Isostearate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-Laureth Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-Lauryl Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA- Linoleate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-Methyl Myristate Sulfonate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-Myreth Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-Myristate 1 safe in the present practicesof use and concentrationwhen formulated to be
Final report 09/11available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
non-irritating, exceptdo not use in cosmetic
products in which N-nitrosocompounds can be formed
DEA-Myristyl Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
DEA-Stearate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final report 09/11available from CIR
Deceth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Deceth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Deceth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Deceth-6 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Deceth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Deceth-8 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Deceth-9 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Decyl betaine 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2014available from CIR
Decyl Castorate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Decyl Cocoate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 30(S1):5S-16S;final report 03/2013available from CIR
Decylene Glycol 1 concentration not reported* IJT 31 (S2): 147-168,2012
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Decyl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
Decyl Isostearate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Decyl Jojobate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Decyl Laurate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Decyl Myristate 1 not in use at the time* safe for use in cosmetics whenformulated to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Decyl Oleate 1 up to 88% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(2):85-95,1982 confirmed
11/01 IJT22(S1):1-35, 2003;
final report 03/2013available from CIR
Decyl Olivate 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Decyl Palmitate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Decyl succinate 1 not in use at the time* IJT 31 (S1):5-76,2012
Decyltetradeceth-10 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Decyltetradeceth-15 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Decyltetradeceth-20 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Decyltetradeceth-25 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Decyltetradeceth-30 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Decyltetradeceth-5 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Decyltetradecyl Cetearate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Decyltetradecyl ethylhexanoate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Dehydroacetic Acid 1 up to 0.7% JACT 4(3):123-59, 1985 confirmed
11/03 IJT 25(S2),2006
Dehydroxanthan gum 1 0.1 to 1% Final report 09/12available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Denatonium Benzoate 1 1/16 avoidupois ounceper 100 gal alcohol
IJT 27 (S1):1-43,2008
Dextran 1 0.000005 to 0.2% Final report 09/12available from CIR
Dextran hydroxypropyltrimonium chloride 1 not in current use * Final report 09/12available from CIR
Dextran sulfate 1 0.01 to 0.1% Final report 09/12available from CIR
Diammonium citrate 1 concentration not reported* IJT 33 (S2): 16-46,2014
Diammonium EDTA 1 not in current use * IJT 21 (S2):95-142,2002
Diamyl sodium sulfosuccinate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Diazolidinyl Urea 1 up to 0.5% JACT 9(2):229-45, 1990 confirmed
12/06Dibehenyl Fumarate 1 not in current use * Final report 03/09 -
Available from CIRDibutyl Adipate (Amended) 1 concentration not reported
in 2010; 5 to 8% in 1996IJT 25(S1):129-134,
2006 JACT15(4):295-300, 1996
(original Report);Final report 12/10
available from CIRDibutyloctyl malate 1 not in current use* Final report 09/12
available from CIRDibutyloctyl sebacate 1 not in current use* IJT 31(S1):5-76,
2012Dibutyl Phthalate 1 up to 15% JACT 4(3):267-
303, 1985confirmed 11/02 IJT24(S1):34-42, 2005reconfirmed 09/05
Dibutyl sebacate 1 not in current use* Final report 12/10available from CIR
Di-C12-13 Alkyl Malate 1 1.0 to 36% Final report 09/12available from CIR
Di-C12 - 15 Alkyl Adipate 1 not in current use* IJT 31(S1):5-76,2012
Di-C12 - 15 Alkyl Fumarate 1 up to 5% Safety Assessment03/09 - Available
from CIRDicapryl/capryl sebacate 1 not in use at the time* IJT 31 (S1):5-76,
2012Dicapryl adipate 1 concentration not reported* IJT 31 (S1):5-76,
2012
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Dicapryl sodium sulfosuccinate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 09/13available from CIR
Dicapryl succinate 1 not in use at the time* IJT 31 (S1):5-76,2012
Dicetearyl Dimer Dilinoleate 1 up to 7% IJT 22 (S2):45-61,2003
Dicetearyl succinate 1 not in use at the time* IJT 31 (S1):5-76,2012
Dicetyl adipate 1 not in use at the time* IJT 31 (S1):5-76,2012
Dicetyl phosphate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Dicetyl Thiodipropionate 1 safe for use in cosmeticformulations when formulated
to be non-irritating
JACT 11(1):25-41,1992 (original
report); JACT 29(S3): 137-150, 2010
Dichlorophene 1 IJT 23(S1):1-27 2004Diethanolamine 1 safe in the present practices
of use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
JACT 2 (7):183-235,1983 - Final amended
report 09/11
Diethanolamine Bisulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except
do not use in cosmeticproducts in which N-nitrosocompounds can be formed
Final amended report09/11
Diethyl adipate 1 not in current use* IJT 31(S1):5-76,2012
Diethylene glycol diethyl-hexanoate/diisononanoate 1 up to 19% IJT 30(S3):228-269,2011
Diethylene Glycol Diisononanoate 1 not in current use* IJT 30(S3):228-269,2011
Diethylhexyl Adipate 1 0.6 to 14% JACT 3 (3):101-30,1984 confirmed
06/03 IJT24(S1):44-47, 2005;
Final report 12/10available from CIR
Diethylhexyl Dimer Dilinoleate 1 1 IJT 22 (S2):45-61,2003
Diethylhexyl Fumarate 1 not in current use * Final report 03/09 -Available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Diethylhexyl Malate 1 0.4 to 2% Final report 09/12available from CIR
Diethylhexyl sebacate 1 not in current use* Final report 12/10available from CIR
Diethylhexyl Sodium Sulfosuccinate 1 5% IJT (S4):1-20, 1998;Final report 09/2013
available from CIRDiethylhexyl succinate 1 0.02 to 6% IJT 31 (S1):5-76,
2012Diethyl malonate 1 0.004 to 0.02% IJT 31 (S1):5-76,
2012Diethyl Phthalate 1 up to 2% JACT 4(3):267-
303, 1985confirmed 11/02 IJT24(S1):34-42, 2005reconfirmed 09/05
Diethyl sebacate 1 1.50% IJT 31(S1):5-76,2012
Diethyl succinate 1 not in current use* IJT 31 (S1):5-76,2012
Di-HEMA Trimethylhexyl Dicarbamate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Diheptyl sodium sulfosuccinate 1 Final report 09/2013available from CIR
Diheptylundecyl adipate 1 6% Final report 12/10available from CIR
Dihexyl adipate 1 3% Final report 12/10available from CIR
Dihexyldecyl adipate 1 not in use at the time* Final report 12/10available from CIR
Dihexyldecyl sebacate 1 0.5 to 5% Final report 12/10available from CIR
Dihexyl sodium sulfosuccinate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Dihydrogenated tallow benzylmonium hectorite 1 not in use at the time* IJT 32(S4):33-40,2013
Dihydrophytosteryl octyldecanoate 1 not in current use* Final report 12/2013available from CIR
Diisoamyl Malate 1 not in current use* Final report 09/12available from CIR
Diisobutyl adipate 1 0.001 to 3% Final report 12/10available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Diisobutyl glutarate 1 not in use at the time* Final report 12/10available from CIR
Diisobutyl sodium sulfosuccinate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Diisobutyl succinate 1 not in use at the time* Final report 12/10available from CIR
Diisocetyl adipate 1 not in use at the time* Final report 12/10available from CIR
Diisocetyl dodecanedioate 1 0.9 to 7% IJT 31 (S1):5-76,2012
Diisodecyl adipate 1 concentration not reported* Final report 12/10available from CIR
Diisononyl adipate 1 not in use at the time* Final report 12/10available from CIR
Diisooctyl adipate 1 not in use at the time* Final report 12/10available from CIR
Diisooctyl sebacate 1 1 to 3% Final report 12/10available from CIR
Diisopropanolamine 1 safe for use in cosmeticproducts; but should not beused in products containing
N-nitrosating agents
JACT 6(1):53-76,1987 confirmed12/04
IJT 25(S2), 2006
Diisopropyl Adipate 1 0.005 to 8% JACT 3 (3):101-30,1984 confirmed
06/03 IJT24(S1):44-47, 2005;
Final report 12/10available from CIR
Diisopropylamine 1 safe for use in cosmeticproducts; but should not beused in products containing
N-nitrosating agents
JACT 14(3):182-92,1995 confirmed
12/09
Diisopropyl Dimer Dilinoleate 1 up to 53% IJT 22(S2):45-61,2003
Diisopropyl sebacate 1 0.06 to 10% IJT 31 (S1):5-76,2012
Diisostearyl adipate 1 3 to 10% Final report 12/10available from CIR
Diisostearyl Dimer Dilinoleate 1 up to 12% IJT 22(S2):45-61,2003
Diisostearyl Fumarate 1 up to 20% Final report 03/09 -Available from CIR
Diisostearyl Glutarate 1 not in current use* Final report 12/10available from CIR
Diisostearyl malate 1 0.001 to 82% Final report 09/12available from CIR
Diisostearyl sebacate 1 0.005 to 0.7% IJT 31 (S1):5-76,2012
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Dilauryl citrate 1 concentration not reported* IJT 33 (S2): 16-46,2014
Dilauryl Thiodipropionate 1 safe for use in cosmeticformulations when formulated
to be non-irritating
JACT 11(1):25-41,1992 (original
report); JACT 29(S3): 137-150, 2010
Dilinoleamidopropyl dimethylamine 1 not in current use* safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Dimethicone 1 up to 80% in hairpreparations; up
to 24% in makeup
IJT 22(S2):11-35,2003
Dimethicone/bis-isobutyl PPG-20 crosspolymer 1 concentration not reported* IJT 33 (S2): 65-115,2014
Dimethicone/bis-vinyldimethicone/silsesquioxanecrosspolymer
1 0.5 to 5% IJT 33 (S2): 65-115,2014
Dimethicone/divinyldimethicone/silsesquioxanecrosspolymer
1 0.5 to 5% IJT 33 (S2): 65-115,2014
Dimethicone/lauryl dimethicone/bis-vinyldimethiconecrosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Dimethicone/PEG-10/15 crosspolymer 1 0.03 to 3% IJT 33 (S2): 65-115,2014
Dimethicone/PEG-10 crosspolymer 1 0.50% IJT 33 (S2): 65-115,2014
Dimethicone/PEG-15 crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Dimethicone/phenyl vinyl dimethicone crosspolymer 1 0.8 to 2% IJT 33 (S2): 65-115,2014
Dimethicone/PPG-20 crosspolymer 1 0.20% IJT 33 (S2): 65-115,2014
Dimethicone/titanate crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Dimethicone/vinyl dimethicone crosspolymer 1 0.003 to 46% IJT 33 (S2): 65-115,2014
Dimethicone/vinyltrimethylsiloxysilicate crosspolymer 1 0.04 to 6% IJT 33 (S2): 65-115,2014
Dimethicone Copolyol 1 up to 1% JACT 1(4):33- 54,1982 confirmed
02/03 IJT24(S1):42-44, 2005
Dimethicone crosspolymer 1 0.007 to 25% IJT 33 (S2): 65-115,2014
Dimethicone crosspolymer-3 1 0.2 to 2% IJT 33 (S2): 65-115,2014
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Dimethicone PEG/PPG-7/4 Phosphate, DimethiconePEG/PPG-12/4 Phosphate, Dimethicone PEG/PPG-20/23Benzoate
3 concentration not reported* JACT 1(4):33-54,1982 4 confirmed
02/03 IJT24(S1):42-44, 2005
Dimethicone PEG-10 Phosphate 1 concentration not reported* JACT 1(4):33-54,1982 4 confirmed
02/03 IJT24(S1):42-44, 2005
Dimethicone PEG-6 Acetate 1 concentration not reported* JACT 1(4):33-54,1982 4 confirmed
02/03 IJT24(S1):42-44, 2006
Dimethicone PEG-7 Phosphate 1 up to 0.5% JACT 1(4):33-54,1982 4 confirmed
02/03 IJT24(S1):42-44, 2005
Dimethicone PEG-8 Adipate 1 concentration not reported* JACT 1(4):33-54,1982 4 confirmed
02/03 IJT24(S1):42-44, 2007
Dimethicone PEG-8 Benzoate 1 up to 0.5% JACT 1 (4):33-54,1982 4 confirmed
02/03 IJT24(S1):42-44, 2005
Dimethiconol 1 0.004 to 36% IJT 33 (S2): 65- 115,2014
Dimethiconol/methylsilanol/silicate crosspolymer 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol/silica crosspolymer 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol/silsesquioxane copolymer 1 0.30% Final report 12/10available from CIR
Dimethiconol/stearyl methicone/phenyl trimethiconecopolymer
1 not in use at the time* Final report 12/10available from CIR
Dimethiconol arginine 1 concentration not reported* Final report 12/10available from CIR
Dimethiconol beeswax 1 0.8 to 0.9% Final report 12/10available from CIR
Dimethiconol behenate 1 0.50% Final report 12/10available from CIR
Dimethiconol borageate 1 0.50% Final report 12/10available from CIR
Dimethiconol candelillate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol carnaubate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol cysteine 1 0.07% Final report 12/10available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Dimethiconol dhupa butterate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol hydroxystearate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol illipe butterate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol isostearate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol kokum butterate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol lactate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol meadowfoamate 1 0.5 to 1% Final report 12/10available from CIR
Dimethiconol methionine 1 concentration not reported* Final report 12/10available from CIR
Dimethiconol mohwa butterate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol panthenol 1 0.07% Final report 12/10available from CIR
Dimethiconol sal butterate 1 not in use at the time* Final report 12/10available from CIR
Dimethiconol stearate 1 1% Final report 12/10available from CIR
Dimethoxysilyl Ethylenediaminopropyl Dimethicone 1 not in current use1 * IJT 22(S2):11-35,2003
Dimethyl adipate 1 0.20% Final report 12/10available from CIR
Dimethyl Behenamine 1 not in current use * Amended FinalReport 12-09 -
available from CIRJACT 14(3):193-95,
1995 (original report)Dimethyl Cocamine 1 not in current use * Amended Final
Report 12-09 -available from CIR
JACT 14(3):193-95,1995 (original report)
Dimethyl glutarate 1 0.5 to 15% Final report 12/10available from CIR
Dimethyl Hydrogenated Tallowamine 1 not in current use * Amended FinalReport 12-09 -
available from CIRJACT 14(3):193-95,
1995 (original report)Dimethyl Lauramine 1 not in current use * Amended Final
Report 12-09 -available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
JACT 14(3):193-95,1995 (original report)
Dimethyl Myristamine 1 not in current use * Amended FinalReport 12-09 -
available from CIRJACT 14(3):193-95,
1995 (original report)Dimethyl Palmitamine 1 not in current use * Amended Final
Report 12-09 -available from CIR
JACT 14(3):193-95,1995 (original report)
Dimethyl Phthalate 1 up to 2% JACT 4(3):267-303, 1985
confirmed 11/02 IJT24(S1):34-42, 2005reconfirmed 09/05
Dimethyl Soyamine (amended) 1 not in current use * Amended FinalReport 12-09 -
available from CIRJACT 14(3):193-95,
1995 (original report)Dimethyl Stearamine (amended) 1 up to 4% in non-coloring
hair care productsAmended FinalReport 12-09 -
available from CIRJACT 14(3):193-95,
1995 (original report)Dimethyl succinate 1 not in use at the time* IJT 31 (S1):5-76,
2012Dimethyl Tallowamine 1 not in current use * Amended Final
Report 12-09 -available from CIR
JACT 14(3):193-95,1995 (original report)
Dimyristyl Phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Dimyristyl Thiodipropionate 1 safe for use in cosmeticformulations when formulated
to be non-irritating
JACT 11(1):25-41,1992 (original
report); JACT 29(S3): 137-150, 2010
Dioctyl Adipate 1 up to 38% JACT 3(3):101-30,1984 confirmed
06/03 IJT24(S1):44-47, 2005
Dioctyl Dimer Dilinoleate 1 up to 12% IJT 22 (S2):45-61,2003
Dioctyldocecyl Adipate 1 concentration not reported* Final report 12/10available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Dioctyldocecyl Dimer Dilinoleate 1 up to 10% IJT 22(S2):45-61,2003
Dioctyldocecyl Dodecanedioate 1 not in use at the time* Final report 12/10available from CIR
Dioctyldocecyl Sebacate 1 3 to 8% Final report 12/10available from CIR
Dioctyldodecyl malate 1 not in current use* Final report 09/12available from CIR
Dioctyl Sodium Sulfosuccinate 1 5% IJT 17 (S4):1-20,1998
Dioleyl Phosphate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Dioleyl Tocopheryl Methylsilanol 1 6% IJT 21 (S3):51-116,2002; Final report03/2014 available
from CIRDioscorea Villosa (Wild Yam) Root Extract 1 up to 15% of max.
2% plant solidsIJT 23(S2):49-54,
2004Dipalmitoyl cysteine 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRDipentaerythrityl pentaisononanoate 1 up to 13% IJT 30(S3):228-269,
2011Diphenyl dimethicone /vinyl diphenyl dimethicone/silsesquioxane crosspolymer
1 0.1 to 7% Final report 09/12available from CIR
Diphenyl dimethicone crosspolymer 1 not in current use* Final report 09/12available from CIR
Dipotassium Aspartate 1 not in current use* IJT 32(S4):41-64,2013
Dipotassium Azelate 1 not in use at the time* IJT 31 (S1):5-76,2012
Dipotassium capryloyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Dipotassium EDTA 1 less than 0.1% IJT 21 (S2):95-142,2002
Dipotassium Glycyrrhizate 1 up to 1% IJT 26 (S2):79-112,2007
Dipotassium undecylenoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Dipropyl adipate 1 not in current use * Final report 12/10available from CIR
Dipropylene Glycol 1 up to 50% JACT 4(5):223-48, 1985 confirmed
02/04 IJT 25(S2),2006
Disodium azelate 1 not in current use * IJT 31 (S1):5-76,2012
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Disodium C12-14 pareth-1 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium C12-14 pareth-2 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium C12-14 sec-pareth-12 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium C12-14 sec-pareth-3 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
disodium C12-14 sec-pareth-5 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium C12-14 sec-pareth-7 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium C12-14 sec-pareth-9 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium C12-15 pareth sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium capryloyl glutamate 1 safe for use in cosmetics aslong as they are formulated
to be non-irritating
Final report 12/2013available from CIR
Disodium coceth-3 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium Cocoamphodiacetate 1 0.0006 to 12% JACT 9(2):121-142,1990; re-review IJT
27(Suppl. 1):77-142,2008
Disodium Cocoamphodipropionate 1 0.008 to 15% JACT 9(2):121-142,1990; re-review IJT
27(Suppl. 1):77-142,2008
Disodium cocoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Disodium cupric citrate 1 not in current use* IJT 33 (S2): 16-46,2014
Disodium deceth-5 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
disodium deceth-6 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Disodium Deceth Sulfate 1 not in current use * IJT29(S3) :151-161,2010
Disodium EDTA 1 less than 1% IJT 21(S2):95-142,2002
Disodium Fumarate 1 not in current use * Final report 03/09 -Available from CIR
Disodium Glycyrrhizate 1 not in current use * IJT 26(S2):79-112,2007
Disodium hydrogenated tallow glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Disodium laneth-5 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium laureth-12 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium laureth-6 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium laureth-9 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium laureth sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium Lauriminodipropionate 1 not in current use * IJT 32 (S3):49-55,2013
Disodium lauroyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Disodium Lauryl phosphate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Disodium malyl tyrosinate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Disodium N-lauroyl aspartate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Disodium oleth-3 sulfosuccinate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
Final report 03/12available from CIR
Disodium oleyl phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Disodium sebacate 1 not in current use * IJT 31 (S1):5-76,2012
Disodium stearoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Disodium Succinate 1 0.0005 to 0.4% IJT 31 (S1):5-76,2012
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Disodium Succinoyl Glycyrrhetinate 1 not reported * IJT 26(S2):79-112,2007
Disodium undecylenoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Disperse Black 9 1 up to 0.5% JACT 5(3):205-23,1986 confirmed
12/06Disperse Blue 1 1 up to 1% JACT 14(6):433-51,
1995; confirmed03/2011
Disperse Blue 7 1 IJT 26(S2):65-77,2007
Disperse Violet 1 1 up to 1% JACT 10(1):103-11,1991
Disperse Yellow 3 1 JACT 15(4):301-10,1996
Disteardimonium hectorite 1 0.04 to 28% IJT 32 (S4):33-40,2013
Distearyl citrate 1 not in current use * IJT 33 (S2): 16-46,2014
Distearyl Thiodipropionate 1 safe for use in cosmeticformulations when formulated
to be non-irritating
JACT 11(1):25-41,1992 (original
report); JACT 29(S3): 137-150, 2010
Di-t-Butylhydroquinone 1 JACT 15(4):311-9,1996
Ditridecyl Adipate 1 not in current use * Final report 12/10available from CIR
Ditridecyl Dimer Dilinoleate 1 not in current use * IJT 22(S2):45-61,2003
Ditridecyl sodium sulfosuccinate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating
Final report 09/13available from CIR
Ditridecyl Thiodipropionate (dialkyl esters) 1 safe for use in cosmeticformulations when formulated
to be non-irritating
JACT 11(1):25-41,1992 (original
report); JACT 29(S3): 137-150, 2010
Divinyldimethicone/dimethicone crosspolymer 1 0.007 to 0.7% Final report 09/12available from CIR
DMDM Hydantoin 1 up to 1% JACT 7(3):245-77,1988 confirmed
09/05Dmethicone/polyglycerin-3 crosspolymer 1 concentration not reported* IJT 33 (S2): 65-115,
2014Dodecanedioic acid 1 not in current use * IJT 31 (S1):5-76,
2012Dodecylhexadecyl-trimonium chloride 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Drometrizole 1 0.07% IJT 27(S2): 63-75,2008 JACT
5(5):455-70, 1986(original report)
EDTA 1 up to 2% IJT 21(S2):95-142,2002
Elaeis (Palm) Fruit Oil 1 not in current use* Final report 03/11available from CIR
Elaeis Guineensis (Palm) Butter 1 not in current use* Final report 03/11available from CIR
Elaeis Guineensis (Palm) Kernel Oil 1 0.05 to 23% Final amended report03/11 available
from CIR; IJT 19(S2):7-28, 2000
(original)Elaeis Guineensis (Palm) Oil 1 up to 2% Final amended report
03/11 availablefrom CIR; IJT 19
(S2):7-28, 2000(original)
Elaeis Oleifera Kernel Oil 1 Final report 03/11available from CIR
Elastin Amino Acids 1 not in current use* IJT 33(S4):5-12,2014
Emulsifying Wax N.F. 1 up to 21% JACT 3(3):43- 99,1984 confirmed
06/03 IJT24(S1):67-74, 2005
Erucyl Arachidate 1 not in current use* safe when formulatedto be non-irritating
Final report 03/13available from CIR
Erucyl Erucate 1 not in current use* safe when formulatedto be non-irritating
Final report 03/13available from CIR
Erucyl Oleate 1 not in current use* safe when formulatedto be non-irritating
Final report 03/13available from CIR
Erythorbic Acid 1 up to 1% IJT 18(S3):1-26,1999
Ethanolamine (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available
from CIR; JACT2(7):183-235, 1983
(original report)
Ethanolamine HCl 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to be
Final amended report03/12 available
from CIR; JACT
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
non-irritating; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
2(7):183-235, 1983(original report)
Ethanolamine Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes
and colors; safe at 15.2%(as thioglycolic acid);
hairdressers should avoidskin contact and minimizeconsumer skin exposure
IJT 28(S3):68-133,2009
Ethoxydiglycol 1 up to 80% JACT 4(5):223-48,1985 confirmed
02/04 IJT 25(S2),2006
Ethoxyethanol 1 reproductive &developmental toxicity
IJT 21(S1):9-62,2002
Ethoxyethanol Acetate 1 reproductive &developmental toxicity
IJT 21(S1):9-62,2002
Ethoxyethyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Ethyl Acetate 1 > 50% JACT 8(4):681-705,1989 confirmed
08/06Ethyl Benzoate 1 0.0008 to 0.01% IJT 31(3):342 -372
(2012)Ethylcellulose (amended) 1 up to 4% Amended safety
assessment 03/09Ethyl citrates 1 0.5 to 1% in rinse-off IJT 33 (S2): 16-46,
2014Ethylene/Acrylic Acid/VA Copolymer 1 safe for use when
formulated to avoid irritationIJT 21(S3):1-50,
2002Ethylene/Acrylic Acid Copolymer 1 safe for use when
formulated to avoid irritationIJT 21(S3):1-50,
2002Ethylene/Calcium Acrylate Copolymer 1 safe for use when
formulated to avoid irritationIJT 21(S3):1-50,
2002Ethylene/Magnesium Acrylate Copolymer 1 safe for use when
formulated to avoid irritationIJT 21(S3):1-50,
2002
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Ethylene/Methacrylate Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Ethylene/propylene/styrene copolymer 1 Final report 09/2014available from CIR
Ethylene/Sodium Acrylate Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Ethylene/Zinc Acrylate Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Ethylene Glycol Dimethacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Ethyl Ester of PVM/MA Copolymer (amended) 1 up to 30% Amended FinalReport 06/09
Available from CIRJACT 12(3):243-56,
1993 (original report)Ethyl Glucoside 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 32 (S3): 22-48,
2013Ethyl Glycolate and Ethyl Lactate 1 safe for use in cosmetic
products at concentrations<=10%, at final formulationpH >=3.5, when formulated
to avoid increasing sunsensitivity or when directionsfor use include the daily use
of sun protection. Theseingredients are safe foruse in salon products at
concentrations <=30%, atfinal formulation pH >=3.0,
in products designed forbrief, discontinuous use
followed by thorough rinsingfrom the skin, when applied
by trained professionals,and when application is
accompanied by directions forthe daily use of sun protection.
IJT 17(S1):1-242,1998
Ethyl Hexanediol 1 5% in 1984, butnot in current use *
JACT 13(6):418-36,1994 confirmed
09/09Ethylhexyl Adipate/Palmitate/Stearate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Ethylhexyl Benzoate 1 3 to 4% IJT 31(3):342-372(2012)
Ethylhexyl C10-40 Isoalkyl Acidate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Ethylhexyl Cocoate (amended) 1 up to 41% safe for use in cosmetics whenformulated to be non-irritating
IJT 30(S1):5S-16S;Final report 03/2013
available from CIREthylhexyl Ethylhexanoate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIREthylhexylglycerin 1 IJT 32 (S3): 5-21,
2013Ethylhexyl Hydroxystearate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIREthylhexyl isononanoate 1 up to 75% safe for use in cosmetics when
formulated to be non-irritatingIJT 30(S3):228-269,
2011; final report03/2013 available
from CIREthylhexyl Isopalmitate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIREthylhexyl Isostearate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIREthylhexyl Laurate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIREthylhexyl Myristate 1 not in use at the time* safe for use in cosmetics when
formulated to be non-irritatingIJT
29(S3) :162-186,2010;final report 03/2013available from CIR
Ethylhexyl Neopentanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Ethylhexyl Oleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Ethylhexyl Olivate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Ethylhexyl Palmitate 1 up to 46% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(2):13-35,1982 confirmed
09/01; final report03/2013 available
from CIREthylhexyl Pelargonate 1 2 to 25% safe for use in cosmetics when
formulated to be non-irritatingFinal report 06/10
available from CIR;Final report 03/2013
available from CIREthylhexyl Salicylate 1 safe when formulated to
avoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,
IJT 22(3):1-108
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
directions for use include thedaily use of sun protection.
Ethylhexyl Stearate 1 up to 11% safe for use in cosmetics whenformulated to be non-irritating
JACT 4(5):107-46,1985 confirmed
06/03; final report03/2013 available
from CIREthyl Methacrylate (Amended) 1 safe as used when application
is accompanied by directionsto avoid skin contact because
of the sensitizing potential
IJT 21(S1):63-79,2002 JACT 14(6):
452-67, 1995(Original Report)
Ethyl Myristate 1 not in use at the time* IJT29(S3) :162-186,2010
Ethylparaben (amended) 1 up to 0.4% if used alone;parabens mixture up to 0.8%
IJT 27(S4): 1-82,2008 JACT
3(5):147-209, 1984(original report)
Ethyl Ricinoleate 1 not in current use * IJT 26(S3): 31-772007
Ethyl Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes
and colors; safe at 15.2%(as thioglycolic acid);
hairdressers should avoidskin contact and minimizeconsumer skin exposure
IJT 28(S3):68-133,2009
Euphorbia Cerifera (Candelilla) Wax 0 up to 27% JACT 3(3):1-41,1984 confirmed
06/03 IJT24(S1):48-52, 2005
Euterpe Oleracea Fruit Oil 1 0.00001 to 0.5% Final report 03/11available from CIR
Euterpe Oleracea sterols 1 Final report 12/2013available from CIR
Ferric citrate 1 0.5% in rinse-off;concentration not
reported for leave- on
IJT 33 (S2): 16-46,2014
Ferrous Fumarate 1 up to 0.0003% Final report 03/09 -Available from CIR
Formaldehyde 1 1 safe for use in cosmeticswhen formulated to
ensure use at the minimaleffective concentration,but in no case should theformalin concentration
IJT 32(Suppl.4):5-32, 2013; JACT
3(3):157-84, 1984confirmed 09/03 IJT
25(S2): 1-89, 2006
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
exceed 0.2% (w/w), whichwould be 0.074% (w/w)
calculated as formaldehydeor 0.118% (w/w) calculatedas methylene glycol; safein the present practices ofuse and concentration in
nail hardening products ---unsafe in the present practices
of use and concentrationin hair smoothing products
Formic Acid 1 <=64 ppm of the free acid IJT 16(S3):221-34,1997; Final report01/2014 available
from CIRFragaria Anannassa (Strawberry) Seed Oil 1 not in use at the time* Final report 03/11
available from CIRFragaria Chiloensis (Strawberry) Seed Oil 1 not in use at the time* Final report 03/11
available from CIRFragaria Vesca (Strawberry) Seed Oil 1 not in use at the time* Final report 03/11
available from CIRFragaria Virginiana (Strawberry) Seed Oil 1 not in use at the time* Final report 03/11
available from CIRFructose 1 Final report 03/2014
available from CIRFucose 1 not in current use* Final report 03/2014
available from CIRFullers Earth 1 up to 50% IJT 22(S1):37-102,
2003Fumaric Acid 1 up to 5% Final report 03/09 -
Available from CIRGalactomannans (see CIR report of the same name) Final report 03/12
available from CIRGalactose 1 not in current use* Final report 03/2014
available from CIRGalactosyl Fructose 1 not in current use* Final report 03/2014
available from CIRGalacturonic Acid 1 not in current use* Final report 03/2014
available from CIRGarcinia Indica Seed Butter 1 0.1 to 2% Final report 03/2011
available from CIRGarcinia mangostana amino acids 1 not in current use* IJT 33(S4):5-12,
2014Gellan Gum 1 0.0004 to 0.5% Final report 09/12
available from CIRGevuina Avellana Oil 1 0.002 to 0.2% Final report -3/11
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Gevuina Avellana Seed Oil 1 0.1 to 2% Final report -3/11available from CIR
Gluconic Acid 1 Final report 03/2014available from CIR
Glucose 1 Final report 03/2014available from CIR
Glucose Glutamate 1 IJT 19(S1):11-12,2000
Glutamic Acid 1 0.000004 to 2% IJT 32(S4):41-64,2013
Glutamine 1 0.002 to 0.005% IJT 32(S4):41-64,2013
Glutaral 1 < 0.5% for rinse-off; butshould not be used in products
intended to be aerosolized(insufficient data to supportsafety in leave-on products)
JACT 15(2):98-139,1996
Glutaric acid 1 not in current use * IJT 31 (S1):5-76,2012
Glycerin 1 Final report 12/2014available from CIR
Glyceryl/Sorbitol Oleate/Hydroxystearate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Adipate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Alginate 1 up to 0.5% IJT 23 (S2):55-94,2004
Glyceryl Allyl Ether 1 not in current use* IJT 32 (S3): 5-21,2013
Glyceryl Arachidate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Arachidonate 1 IJT 23(S2):55-94,2004
Glyceryl Behenate 1 up to 5% IJT 23 (S2):55-94,2004
Glyceryl Caprate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Caprylate 1 not reported * IJT 23(S2):55-94,2004
Glyceryl Caprylate/Caprate 1 up to 2% IJT 23(S2):55-94,2004
Glyceryl Capryl Ether 1 not in current use* IJT 32 (S3): 5-21,2013
Glyceryl Citrate/Lactate/ Linoleate/ Oleate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Cocoate 1 up to 5% IJT 23 (S2):55-94,2004
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Glyceryl Collagenate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Diarachidate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dibehenate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dierucate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dihydroxystearate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Diisopalmitate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Diisostearate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is not
IJT 26(S3):1-30,2007
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
high enough to induceepidermal hyperplasia
Glyceryl Dilaurate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dilinoleate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dimyristate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dimyristate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Dioleate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dipalmitate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Dipalmitoleate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
IJT 26(S3):1-30,2007
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
Glyceryl Diricinoleate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Distearate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Erucate 1 up to 0.5% IJT 23 (S2):55-94,2004
Glyceryl Glycyrrhetinate 1 not in current use * IJT 26(S2):79-112,2007
Glyceryl Hydrogenated Rosinate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Hydrogenated Soyate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Hydroxystearate 1 up to 2% IJT 23 (S2):55-94,2004
Glyceryl Isopalmitate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Isostearate 1 up to 6% IJT 23(S2):55- 94,2004
Glyceryl Isostearate/Myristate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Isostearates 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Isotridecanoate/Stearate/ Adipate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Lanolate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Laurate 1 up to 4% IJT 23(S2):55-94,2004
Glyceryl Laurate/Oleate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Laurate SE 1 not in current use * IJT 23(S2):55-94,2004
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Glyceryl Lauryl Ether 1 IJT 32 (S3): 5-21,2013
Glyceryl Linoleate 1 up to 1% IJT 23(S2):55- 94,2004
Glyceryl Linolenate 1 up to 1% IJT 23(S2):55- 94,2004
Glyceryl Montanate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Myristate 1 up to 6% IJT 23(S2):55-94,2004
Glyceryl Oleate 1 up to 5% JACT 5(5):391- 413Glyceryl Oleate/Elaidate 1 up to 2% IJT 23 (S2):55-94,
2004Glyceryl Oleate SE 1 not in current use * IJT 23(S2):55-94,
2004Glyceryl Palmitate 1 not reported * IJT 23 (S2):55-94,
2004Glyceryl Palmitate/Stearate 1 not in current use * IJT 23(S2):55-94,
2004Glyceryl Palmitate Lactate 1 safe as cosmetic ingredients
in the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Palmitoeleate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Pentadecanoate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Polyacrylate 1 up to 2% IJT 23(S2):55 -94,2004
Glyceryl Ricinoleate (amended) 1 up to 12% IJT 26(S3) 2007JACT 7(6):721-39,
1988 (originalreport )
Glyceryl Ricinoleate SE 1 not in current use * IJT 26(S3) 2007Glyceryl Rosinate 1 up to 7% IJT 23(S2):55-94,
2004Glyceryl Sesquioleate 1 not in current use * IJT 23(S2):55-94,
2004Glyceryl Stearate 1 up to 50% JACT 1(4):169-92,
1982Glyceryl Stearate/Acetate 1 up to 7% IJT 23 (S2):55-94,
2004
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Glyceryl Stearate/Maleate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Stearate Citrate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Stearate Diacetate 1 not in current use * IJT 20(S4):61-94,2001
Glyceryl Stearate Lactate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Stearate SE 1 up to 25% JACT 1 (4):169-92,1982
Glyceryl Stearate Succinate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content
of 1,2-diesters is nothigh enough to induceepidermal hyperplasia
IJT 26(S3):1-30,2007
Glyceryl Tallowate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Thioglycolate (amended) 1 safe in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hair
products, and hair dyes andcolors at concentrations up to15.2% (as thioglycolic acid);
hairdressers should avoidskin contact and minimizeconsumer skin exposure
IJT 28(S3):68-133,2009 JACT
10(1):135-92, 1991(original report)
Glyceryl Thiopropionate 1 not in current use * IJT 23(S2):55-94,2004
Glyceryl Triacetyl Hydroxystearate 1 9% IJT 20 (S4):61-94,2001
Glyceryl Triacetyl Ricinoleate 1 8% IJT 20 (S4):61-94,2001
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Glyceryl Undecylenate 1 not reported * IJT 23 (S2):55-94,2004
Glycine 1 0.0005 to 4% IJT 32(S4):41-64,2013
Glycine Soja (Soybean) Oil 1 .0002 to 95% Final report 03/11available from CIR
Glycine Soja (Soybean) Oil Unsaponifiables 1 0.0001 to 0.2% Final report 03/11available from CIR
Glycine Soja (Soybean) Sterols 1 Final report 12/2013available from CIR
Glycol Dimethacrylate/Vinyl Alcohol Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Glycol Distearate 1 up to 9% JACT 1(2):1-11,1982 confirmed
09/01 IJT22(S1):1-35, 2003
Glycol HEMA-Methacrylate (aka Ethylene GlycolDimethacrylate )
1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Glycolic Acid (e.g. Alpha Hydroxy Acids) 1 Glycolic and Lactic Acid,their common salts and their
simple esters, are safe foruse in cosmetic products at
concentrations <=10%, at finalformulation pH >=3.5, when
formulated to avoid increasingsun sensitivity or when
directions for use include thedaily use of sun protection.These ingredients are safefor use in salon products atconcentrations <=30%, at
final formulation pH >=3.0,in products designed forbrief, discontinuous use
followed by thorough rinsingfrom the skin, when applied
by trained professionals,and when application is
accompanied by directions forthe daily use of sun protection.
IJT 17(S1):1-242,1998
Glycol Ricinoleate 1 not in current use * IJT 26(S3):31-77,2007
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Glycol Stearate 1 up to 6% JACT 1(2):1-11,1982 confirmed
09/01 IJT22(S1):1-35, 2003
Glycol Stearate SE 1 up to 12% JACT 1(2):1-11,1982 confirmed
09/01 IJT22(S1):1-35, 2003
Glycyrrhetinic Acid 1 up to 2% IJT 26(S2):79- 112,2007
Glycyrrhetinyl Stearate 1 not in current use * IJT 26(S2):79-112,2007
Glycyrrhiza Glabra (Licorice) Leaf Extract 1 concentration not reported* Final report 09/08available from CIR
Glycyrrhiza Glabra (Licorice) Rhizome/Root 1 0.0001 to 0.4% Final report 09/08available from CIR
Glycyrrhiza Glabra (Licorice) Root 1 0.0001 to 0.4% Final report 09/08available from CIR
Glycyrrhiza Glabra (Licorice) Root Extract 1 0.0001 to 0.4% Final report 09/08available from CIR
Glycyrrhiza Glabra (Licorice) Root Extract [polyol soluble] 1 0.0001 to 0.06% Final report 09/08available from CIR
Glycyrrhiza Glabra (Licorice) Root Juice 1 not in current use* Final report 09/08available from CIR
Glycyrrhiza Glabra (Licorice) Root Powder 1 not in current use* Final report 09/08available from CIR
Glycyrrhiza Glabra (Licorice) Root Water 1 not in current use* Final report 09/08available from CIR
Glycyrrhiza Inflata Root Extract 1 not in current use* Final report 09/08available from CIR
Glycyrrhiza Inflata Root Extract [polyol soluble] 1 0.0001 to 15% Final report 09/08available from CIR
Glycyrrhiza Uralensis (Licorice) Root Extract 1 not in current use* Final report 09/08available from CIR
Glycyrrhizic Acid 1 up to 0.1% IJT 26(S2):79- 112,2007
Glyoxal (Amended) 1 1.25% in products intendedto be applied to the nail
JACT 14(5):348-63,1995 IJT
19(1):13-27, 2000Gossypium (Cotton) Seed Oil 1 IJT 20(S2):21-29,
2001Gossypium Herbaceum (Cotton) Seed Oil 1 0.004 to 32% Final report 03/11
available from CIRGrape Seed Oil PEG-8 esters 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014Guar hydroxypropyltrimonium chloride 1 0.005 to 2% Final report 03/12
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Guizotia Abyssinica Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hair keratin amino acid 1 IJT 33(S4):5-12,2014
Hazel Seed Oil PEG-8 Esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
HC Blue No. 1 1 carcinogenicity JACT 13(5):344 -60,1994
HC Blue No. 2 1 2% in a hair dye(diluted in use to 1%)
JACT 13(5):361-73,1994; confirmed IJT30(Suppl. 2):98-99,
2011HC Orange No. 1 1 safe for use in hair
dyes up to 3%IJT 17(S4):21-38,
1998HC Red No. 1 1 0.5% JACT 15(4):320-36,
1996; confirmed06/2011
HC Red No. 3 1 safe as used in hair dyes;but should not be usedin products containingN-nitrosating agents
JACT 11(4):509-19,1992
HC Red No. 7 1 up to 1% Final Report 06/06Available from CIR
HC Yellow No. 2 1 up to 3% JACT 13(3):157-66,1994 confirmed
12/08HC Yellow No. 4 1 <= 3% IJT 17(S4):39-70,
1998HC Yellow No. 5 1 up to 1.6% IJT 26(S2):113- 124,
2007Hectorite 1 100% in a skin cleanser;
up to 15% in other usesIJT 22(S1):37-102,
2003HEDTA 1 concentration not reported * IJT 21 (S2):95-142,
2002Helianthus Annuus (Sunflower) Seed Oil 1 0.000007 to 96% Final report 03/11
available from CIRHelianthus Annuus (Sunflower) Seed Oil Unsaponifiables 1 0.005 to 2% Final report 03/11
available from CIRHEMA 1 safe in nail enhancement
products when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
HEMA Acetoacetate 1 safe in nail enhancementproducts when skin contact is
IJT 24(S5):53-100,2005
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
avoided; products containingthis ingredient should be
accompanied with directionsto avoid skin contact
because of the sensitizingpotential of methacrylates
Heptyl undecylenate 1 safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Heptylundecyl hydroxystearate 1 safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Hexacosyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012
Hexadecyl D-glucoside 1 safe as used in cosmeticswhen formulated
to be non-irritating
IJT 32 (S3): 22-48,2013
Hexamidine 1 safe at concentrationsless than or equal to 0.1%
IJT 26(S3) 2007
Hexamidine Diisethionate 1 safe at concentrationsless than or equal to 0.1%
IJT 26(S3) 2007
Hexapeptide-12 1 not in current use* Final report 06/2014available from CIR
Hexyldeceth-2 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT32(S2):169-244(2012)
Hexyldeceth-20 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT32(S2):169-244(2012)
Hexyldecyl Benzoate 1 not in use at the time* IJT 31(3):342-372(2012)
Hexyldecyl ethylhexanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hexyldecyl hexyldecanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hexyldecyl isostearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hexyldecyl laurate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hexyldecyl oleate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hexyldecyl palmitate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hexyldecyl stearyl 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hexyldodecyl/ octyldecyl hydroxystearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Hexyldodecyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Hexylene Glycol 1 up to 6% JACT 4(5):223-48,1985 confirmed
02/04 IJT 25(S2),2006
Hexyl isostearate 1 safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Hexyl laurate 1 safe as used in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Hexyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Hexyl Methicone 1 not in current use * IJT 22 (S2):11-35,2003
Hippophae Rhamnoides Fruit Oil 1 6 to 35% Final report 03/11available from CIR
Hippophae Rhamnoides Oil 1 0.2 to 0.7 Final report 03/11available from CIR
Hippophae Rhamnoides Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Histidine 1 0.00009 to 0.05% IJT 32(S4):41-64,2013
Histidine HCl 1 0.00003 to 0.07% IJT 32(S4):41-64,2013
Human Placental Enzymes 1 if used, should not deliverany metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Human Placental Lipids 1 if used, should not deliverany metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Human Placental Protein 1
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Human Umbilical Extract 1 if used, should not deliverany metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Hyaluronic Acid 1 up to 1% IJT 28 (1): 5-67,2009
Hydrated Silica 1 up to 34% Final Report 09/09available from CIR
Hydrogenated Adansonia Digitata Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Apricot Kernel Oil 1 concentration not reported* Final report 03/11available from CIR
Hydrogenated Apricot Kernel Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Argania Spinosa Kernel Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Avocado Oil 1 up to 5% Final report 03/11available from CIR
Hydrogenated Black Currant Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Butadiene/Isoprene/Styrene Copolymer 1 not in current use* Final report 09/2014available from CIR
Hydrogenated Butylene/Ethylene/Styrene Copolymer 1 Final report 09/2014available from CIR
Hydrogenated Camelina Sativa Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Camellia Oleifera Seed Oil 1 concentration not reported* Final report 03/11available from CIR
Hydrogenated Canola Oil 1 concentration not reported* Final report 03/11available from CIR
Hydrogenated Castor Oil 1 up to 39% IJT 26 (S3):31-77,2007
Hydrogenated Castor Oil Behenyl esters 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hydrogenated castor Oil cetyl esters 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hydrogenated castor oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Hydrogenated castor oil stearyl esters 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hydrogenated Cocoglycerides (amended) 1 up to 31% IJT 30(S1):5S-16SHydrogenated Coconut Acid (amended) 1 6 to 10% IJT 30(S1):5S-16S;
JACT 5(3):103-21,1986 (original report)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Hydrogenated Coconut Oil (amended) 1 0.001 to 50% IJT 30(S1):5S-16S;JACT 5(3):103-21,
1986 (original report)Hydrogenated Cottonseed Glyceride 1 safe as used in cosmetic
products, provided thatestablished and imposed limits
on gossypol, heavy metals,and pesticide concentrations
are not exceeded.
IJT 20(S2):21-29,2001
Hydrogenated Cottonseed Oil 1 0.001 to 24% Final report 03/11available from CIR
Hydrogenated Cranberry Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Dimer Dilinoleth-20 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(3):342-372(2012)
Hydrogenated Dimer Dilinoleth-30 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(3):342-372(2012)
Hydrogenated Dimer Dilinoleth-40 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(3):342-372(2012)
Hydrogenated Dimer Dilinoleth-60 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(3):342-372(2012)
Hydrogenated Dimer Dilinoleth-80 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(3):342-372(2012)
Hydrogenated Ethylene/ Propylene/Styrene Copolymer 1 Final report 09/2014available from CIR
Hydrogenated Ethylhexyl olivate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hydrogenated Ethylhexyl sesamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hydrogenated Evening Primrose Oil 1 concentration not reported* Final report 03/11available from CIR
Hydrogenated Grapeseed Oil 1 0.3 to 0.5% Final report 03/11available from CIR
Hydrogenated Grapesuit Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Grapesuit Seed Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Hazelnut Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Isocetyl olivate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hydrogenated Isopropyl Jojobate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Hydrogenated Jojoba Oil (amended) 1 up to 31% Amended FinalReport 09/08 -
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Hydrogenated Kukui Nut Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Laneth-20 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(3):342-372(2012)
Hydrogenated Laneth-25 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(3):342-372(2012)
Hydrogenated Laneth-5 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(3):342-372(2012)
Hydrogenated Lanolin 1 up to 10% JEPT 4(4):63 -92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Hydrogenated Lard 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/
pesticide contamination40ppm with 10ppm for
any specific residue
IJT 20(S2):57-64,2001
Hydrogenated Lard Glyceride 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/
pesticide contamination40ppm with 10ppm for
any specific residue
IJT 20(S2):57-64,2001
Hydrogenated Lard Glycerides 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/
pesticide contamination40ppm with 10ppm for
any specific residue
IJT 20(S2):57-64,2001
Hydrogenated Lecithin 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):21-45,2001
Hydrogenated Lime Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Lime Seed Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Macadamia Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Meadowfoam Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Olive Oil 1 0.0005 to 12% Final report 03/11available from CIR
Hydrogenated Olive Oil Unsaponifiables 1 0.05 to 5% Final report 03/11available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Hydrogenated Orange Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Orange Seed Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Palm/Palm Kernel Oil PEG-6 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Hydrogenated Palm Acid 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Palm Kernel Oil 1 0.4 to 13% Final report 03/11available from CIR
Hydrogenated Palm Oil 1 0.2 to 30% IJT 19 (S2):7-28,2000; Final amended
report 03/11 availablefrom CIR
Hydrogenated Palmtrimonium chloride 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Hydrogenated Passiflora Edulis Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Peach Kernel Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Peanut Oil 1 2 to 5% IJT 20 (S2):65-77,2001; final amended
report 03/11 availablefrom CIR
Hydrogenated Pistachio Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Polyisobutene 1 up to 96% IJT 27 (S4): 83-106,2008
Hydrogenated Pumpkin Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Punica Granatum Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Rapeseed Oil 1 0.3 to 4% Final report 03/11available from CIR
Hydrogenated Raspberry Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Rice Bran Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Rice Bran Wax 1 concentration not reported* IJT 25(S2):91-120,2006
Hydrogenated Rosa Canina Fruit Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Safflower Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Sesame Seed Oil (amended) 1 not in current use* JACT 12(3):261-77,1993 (original
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
report); IJT 30 (1):40-53, 2011
Hydrogenated Shea Butter 1 up to 1% Final report 03/11available from CIR
Hydrogenated Soybean Oil 1 0.001 to 42% Final report 03/11available from CIR
Hydrogenated Styrene/Butadiene Copolymer 1 Final report 09/2014available from CIR
Hydrogenated Styrene/Isoprene Copolymer 1 Final report 09/2014available from CIR
Hydrogenated Sunflower Seed Oil 1 6 to 35% Final report 03/11available from CIR
Hydrogenated Sweet Almond Oil 1 up to 0.5% Final report 03/11available from CIR
Hydrogenated Sweet Almond Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated tallowamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Hydrogenated Tallow Betaine 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2014available from CIR
Hydrogenated Talloweth-12 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(3):342-372(2012)
Hydrogenated Talloweth-25 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(3):342-372(2012)
Hydrogenated Tallow Glyceride 1 up to 25% JACT 9(2):153-64,1990 confirmed
06/06Hydrogenated Tallow Glycerides 1 up to 25% JACT 9(2):153-64,
1990 confirmed06/06
Hydrogenated Tallowtrimonium chloride 1 safe when formulatedto be non-irritating
IJT 31(S3): 296-341(2012)
Hydrogenated Vegetable Oil 1 0.0004 to 60% Final report 03/11available from CIR
Hydrogenated Wheat Germ Oil 1 not in use at the time* Final report 03/11available from CIR
Hydrogenated Wheat Germ Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Hydrolyzed Beta-glucan 1 not in current use* Final report 09/12available from CIR
Hydrolyzed caesalpinia spinosa gum 1 0.002 to 0.4% Final report 03/12available from CIR
Hydrolyzed camellia sinensis leaf 1 not in current use* Final report 09/2014available from CIR
Hydrolyzed camellia sinensis seed extract 1 Final report 09/2014available from CIR
Hydrolyzed Cellulose Gum 1 not in use at the time* Amended safetyassessment03/09 -
Available from CIRHydrolyzed ceratonia siliqua gum extract 1 not in current use* Final report 03/12
available from CIRHydrolyzed Collagen 1 up to 6% JACT 4(5)199- 221,
1985 confirmed06/04 IJT 25(S2),
2006Hydrolyzed Collagen PG-propyl dimethiconol 1 not in use at the time* Final report 03/11
available from CIRHydrolyzed Corn Protein 1 not in use at the time* IJT 30 (S1): 17-39,
2011Hydrolyzed Corn Starch 1 not in use at the time* IJT 30 (S1): 17-39,
2011Hydrolyzed ginseng root 1 not in current use* Final report 09/12
available from CIRHydrolyzed ginseng root extract 1 not in current use* Final report 09/12
available from CIRHydrolyzed ginseng saponins 1 not in current use* Final report 09/12
available from CIRHydrolyzed grape fruit 1 not in current use* Tentative report
06/12 available fromCIR
Hydrolyzed grape skin 1 not in current use* Tentative report06/12 available from
CIRHydrolyzed guar 1 0.03 to 3% Final report 03/12
available from CIRHydrolyzed Human Placental Protein 1 if used, should not deliver
any metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Hydrolyzed Jojoba Esters (amended) 1 up to 2% Amended FinalReport 09/08 -
available from CIRHydrolyzed Oat Flour 1 safe when formulated
to be non- sensitizingFinal report 12/2014
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Hydrolyzed Oat Protein 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Hydrolyzed Oats 1 safe when formulatedto be non- sensitizing
Final report 12/2014available from CIR
Hydrolyzed Placental Protein 1 if used, should not deliverany metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Hydrolyzed Rhizobian Gum 1 0.4 to 3% Final report 09/12available from CIR
Hydrolyzed Rice Bran Extract 1 up to 0.0004% These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
IJT 25(S2):91-120,2006
Hydrolyzed Rice Bran Protein 1 not in current use* These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
IJT 25(S2):91-120,2006
Hydrolyzed Rice Extract 1 up to 0.3% These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
IJT 25(S2):91-120,2006
Hydrolyzed Rice Protein 1 up to 2% These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
IJT 25(S2):91-120,2006
Hydrolyzed Sclerotium gum 1 1% Final report 09/12available from CIR
Hydrolyzed Wheat Gluten 1 safe as used in cosmeticswhen formulated to restrict
peptides to a weight-averagemolecular weight (MW) of3,500 daltons (Da) or less.
Final report 06/2014available from CIR
Hydrolyzed Wheat Protein 1 safe as used in cosmeticswhen formulated to restrict
peptides to a weight-averagemolecular weight (MW) of3,500 daltons (Da) or less.
Final report 06/2014available from CIR
Hydroquinone 1 1 safe at concentrations ofless than or equal to 1%
for cosmetic formulationsdesigned for discontinuous,
brief use followed by rinsing
Unsafe for use in otherleave-on cosmetic products
JACT 5(3):123-65,1986; JACT
13(3):167-230, 1994;IJT 29 (S4): 274-287,
2010; Final report
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
from the skin and hair.Hydroquinone is safe for
use in nail adhesives and inartificial nail coatings, as
a polymerization inhibitor,that are cured by LED light.
12/2014 availablefrom CIR
Hydroxybenzomorpholine 1 0.03% JACT 10(1):205- 13,1991
Hydroxybutyl Methylcellulose 1 not in use at the time* Amended safetyassessment 03/09 -
Available from CIRHydroxycetyl isostearate 1 not in current use* safe as used in cosmetics
when formulatedto be non-irritating
Final report 03/2013available from CIR
Hydroxyethylcellulose (amended) 1 up to 6% Amended safetyassessment 03/09 -
Available from CIRJACT 5(3):1-59,
1986 (original report)Hydroxyethyl Ethylcellulose (amended) 1 up to 3% Amended safety
assessment 03/09 -Available from CIR
Hydroxyethylmethacrylate Acetoacetate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Hydroxylated Lanolin 1 up to 28% JEPT 4(4):63- 92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Hydroxyoctacosanyl Hydroxystearate ` safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Hydroxypropyl Bis(N-Hydroxyethyl-p-Phenylenediamine)HCl
1 Final report 09/2013available from CIR
Hydroxypropylcellulose (amended) 1 up to 4% Amended safetyassessment 03/09 -
Available from CIRJACT 5(3):1-59,
1986 (original report)Hydroxypropyldimethicone 1 not in current use* IJT 22(S2):11-35,
2003Hydroxypropyl dimethicone/polysorbate 20 crosspolymer 1 not in current use* Final report 09/12
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Hydroxypropyl guar 1 0.05 to 2% in leave-on;0.1 to 93% in rinse- off
Final report 03/12available from CIR
Hydroxypropyl guar hydroxypropyltrimonium chloride 1 0.04 to 0.9% Final report 03/12available from CIR
Hydroxypropyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Hydroxypropyl Methylcellulose (amended) 1 up to 4% Amended safetyassessment 03/09 -
Available from CIR;JACT 5(3):1-59,
1986 (original report)Hydroxypropyl Methylcellulose Acetate/Succinate 1 not in use at the time* Amended Safety
Assessment 03/09available from CIR
Hydroxypropyl xanthan gum 1 not in current use* Final report 09/12available from CIR
Hydroxystearamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Hydroxystearic Acid 1 up to 10% IJT 18(S1):1- 10,1999
Hypericum Perforatum Extract 1 IJT 20(S2):31-39,2001; IJT
33(S3):5-23, 2014Hypericum Perforatum Flower/Leaf/Stem Extract 1 IJT 33(S3):5-23,
2014Hypericum Perforatum Flower/Leaf Extract 1 not in current use* IJT 33(S3):5-23,
2014Hypericum Perforatum Flower/Twig Extract 1 not in current use* IJT 33(S3):5-23,
2014Hypericum Perforatum Flower Extract 1 IJT 33(S3):5-23,
2014Hypericum Perforatum Leaf Extract 1 not in current use* IJT 33(S3):5-23,
2014Hypericum Perforatum Oil 1 IJT 20(S2):31-39,
2001; IJT33(S3):5-23, 2014
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Imidazolidinyl Urea 1 up to 1% JEPT 4(4):133- 46,1980 confirmed
09/01 IJT22(S1):1-35, 2003
Iodopropynyl Butylcarbamate (IPBC) 1 safe for use at 0.1%; shouldnot be used in products
intended to be aerosolized
IJT 17(S5):1-37,1998
Irvingia Gabonensis Kernel Butter 1 0.003 to 0.4% Final report 03/11available from CIR
Isoamyl Acetate 1 up to 10% JACT 7(6):705-19,1988
Isoamyl Laurate 1 safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Isobornyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Isobutane 1 up to 85% JACT 1(4):127-42,1982 confirmed
06/02 IJT24(S1):52-55, 2005
Isobutyl Acetate 1 6 to 45% IJT 31(S1):112-136,2012
Isobutyl Benzoate 1 0.01% IJT 31(3):342-372(2012)
Isobutylene/styrene copolymer 1 Final report 09/2014available from CIR
Isobutyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Isobutyl Myristate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Isobutyl Palmitate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
final report 03/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Isobutylparaben 1 up to 0.4% if used alone;parabens mixture up to 0.8%
IJT 27(S4):1-82, 2008
JACT14(5):364-372,1995 (original report)
Isobutyl Pelargonate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
Final report 06/10available from CIR;final report 03/2013available from CIR
Isobutyl Stearate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
JACT 4(5):107-46,1985 confirmed
06/03 IJT24(S1):21-25, 2005;final report 03/2013available from CIR
Isobutyl Tallowate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
final report 03/2013available from CIR
Isoceteth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244,2012
Isoceteth-12 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244,2012
Isoceteth-15 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244,2012
Isoceteth-20 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244,2012
Isoceteth-25 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244,2012
Isoceteth-30 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244,2012
Isoceteth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244,2012
Isoceteth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244,2012
Isocetyl Behenate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isocetyl ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isocetyl Isodecanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Isocetyl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isocetyl Laurate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isocetyl Myristate 1 concentration not reported* safe for use in cosmetics whenformulated to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Isocetyl Palmitate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isocetyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Isocetyl Stearate 1 up to 30% safe for use in cosmetics whenformulated to be non-irritating
JACT 4(5):107-46,1985 confirmed
06/03 IJT24(S1):21-25, 2005;final report 03/2013available from CIR
Isodeceth-4 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 12/10available from CIR
Isodeceth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 12/10available from CIR
Isodeceth-6 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 12/10available from CIR
Isodecyl citrate 1 concentration not reported* IJT 33 (S2): 16-46,2014
Isodecyl Cocoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT 30(S1):5S-16S;final report 03/2013available from CIR
Isodecyl ethylhexanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isodecyl glyceryl ether 1 not in current use* IJT 32 (S3): 5-21,2013
Isodecyl Hydroxystearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isodecyl isononanoate 1 up to 59% safe for use in cosmetics whenformulated to be non-irritating
IJT 30(S3):228-269,2011; final report03/2013 available
from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Isodecyl laurate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isodecyl Myristate 1 concentration not reported* safe for use in cosmetics whenformulated to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Isodecyl Neopentanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isodecyl Oleate 1 up to 8% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(2):85-95,1982 confirmed
11/01 IJT22(S1):1-35, 2003;
final report 03/2013available from CIR
Isodecyl Palmitate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isodecyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Isodecyl Stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isododecane 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
Isoeicosane 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
Isohexadecane 1 safe when formulatedto be non- irritating
IJT 31(S3): 269-295(2012)
Isohexyl Caprate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isohexyl Laurate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isohexyl Neopentanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isohexyl Palmitate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isolaureth-10 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isolaureth-3 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isolaureth-6 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isolauryl Behenate 1 safe for use in cosmetics whenformulated to be non-irritating
final report 03/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Isoleucine 1 0.0003 to 0.002% IJT 32(S4):41-64,2013
Isomalt 1 Final report 03/2014available from CIR
Isomerized Jojoba Oil (amended) 1 not in current use* Amended FinalReport 09/08 -
available from CIRIsomyreth-3 1 safe when formulated
to be non- irritatingIJT 31(S2):169-244
(2012)Isomyreth-9 1 safe when formulated
to be non- irritatingIJT 31(S2):169-244
(2012)Isononyl isononanoate 1 up to 64% IJT 30 (S3):228-269,
2011; final report03/2013 available
from CIRIsooctane 1 safe when formulated
to be non- irritatingIJT 31(S3): 269-295
(2012)Isooctyl Caprylate/Caprate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsooctyl Tallate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsooctyl Thioglycolate 1 safe in hair straighteners,
permanent waves, tonics,dressings, etc., wave sets,other non-coloring hair
products, and hair dyes andcolors at concentrations up to15.2% (as thioglycolic acid);
hairdressers should avoidskin contact and minimizeconsumer skin exposure
IJT 28(S3):68-133,2009
Isopentane 1 up to 37% JACT 1(4):127-42,1982 confirmed
06/02 IJT24(S1):52-55, 2005
Isopolyglyceryl-3 dimethiconol 1 not in current use* Final report 12/10available from CIR
Isopropanolamine 1 safe for use in cosmeticproducts; but should not beused in products containing
N-nitrosating agents
JACT 6(1):53-76,1987 confirmed
12/04 IJT 25(S2),2006
Isopropyl Acetate 1 0.5 to 2% IJT 31(S1):112- 136,2012
Isopropyl Alcohol 1 0.002 to 100% (100% inmanicuring preparations)
IJT 31(S1):112-136,2012
Isopropylamine Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 29 (S4) 288-305,2010
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Isopropyl Arachidate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isopropyl Avocadate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isopropyl Babassuate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isopropyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isopropyl Benzoate 1 IJT 31(3):342-372(2012)
Isopropyl citrate 1 not in current use* IJT 33 (S2): 16-46,2014
Isopropyl Cresols 1 up to 5% IJT 25(S1):29-127,2006 (Amended
Report)Isopropyl Ester of PVM/MA Copolymer (amended) 1 not in current use* Amended Final
Report 06/09Available from CIRJACT 12(3):243-56,
1993 (original report)Isopropyl Hydroxystearate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsopropylidenediphenyl Bisglycidyl Methacrylate 1 safe in nail enhancement
products when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Isopropyl Isostearate 1 up to 65% safe for use in cosmetics whenformulated to be non-irritating
JACT 11(1):43-9,1992; final report03/2013 available
from CIRIsopropyl Jojobate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsopropyl Lactate 1 Glycolic and Lactic Acid,
their common salts and theirsimple esters, are safe for
use in cosmetic products atconcentrations <=10%, at finalformulation pH >=3.5, when
formulated to avoid increasingsun sensitivity or when
directions for use include thedaily use of sun protection.These ingredients are safefor use in salon products at
IJT 17(S1):1-242,1998
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
concentrations <=30%, atfinal formulation pH >=3.0,
in products designed forbrief, discontinuous use
followed by thorough rinsingfrom the skin, when applied
by trained professionals,and when application is
accompanied by directions forthe daily use of sun protection.
Isopropyl Lanolate 1 up to 26% JEPT 4(4):121- 32,1980 confirmed
06/01 IJT22(S1):1-35, 2003
Isopropyl Laurate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isopropyl Linoleate 1 safe for use in cosmetics whenformulated to be non-irritating
JACT 11(1):51-56,1992; final report03/2013 available
from CIRIsopropyl Myristate 1 up to 82% safe for use in cosmetics when
formulated to be non-irritatingJACT 1(4):55-80,
1982 confirmed06/02 IJT
24(S1):63-67, 2005;final report 03/2013available from CIR
Isopropyl Oleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isopropyl Palmitate 1 up to 44% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(2):13-35,1982 confirmed
09/01 IJT24(S1):28-32, 2005;final report 03/2013available from CIR
Isopropylparaben 1 up to 0.4% if used alone;parabens mixture up to 0.8%
IJT 27(S4):1-82, 2008
JACT14(5):364-372,1995 (original report)
Isopropyl Ricinoleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT 26(S3) 2007;final report 03/2013available from CIR
Isopropyl Stearate 1 up to 87% safe for use in cosmetics whenformulated to be non-irritating
JACT 4(5):107-146,1985 confirmed
06/03 IJT24(S1):21-25, 2005;final report 03/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Isopropyl Tallowate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isopropyl Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes
and colors; safe at 15.2%(as thioglycolic acid);
hairdressers should avoidskin contact and minimizeconsumer skin exposure
IJT 28(S3):68-133,2009
isopropyl titanium triisostearate/triethoxysilylethylpolydimethylsiloxyethyl dimethicone crosspolymer
1 concentration not reported* Final report 09/12available from CIR
Isostearamide DEA (amended) 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Isostearamide MEA (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Isostearamidopropyl Betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Isostearamidopropyl Dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Isostearamidopropyl Morpholine Lactate 1 safe for use in rinse-off products; data are
insufficient to support safetyin leave-on formulations
IJT 18(S3):51-56,1999
Isosteareth-10 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Isosteareth-12 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-15 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-16 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-2 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-20 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-22 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-25 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-3 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-5 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-50 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isosteareth-8 1 safe when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Isostearic Acid 1 up to 26% JACT 2(7):61-74,1983 confirmed
09/02 IJT24(S1):55-56, 2005
Isostearyl Acetate 1 0.002 to 5% IJT 31 (S1):112-136,2012
Isostearyl Alcohol 1 up to 50% JACT 7(3):359-413, 1988 confirmed
12/05Isostearyl Avocadate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl Behenate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl Benzoate 1 1% IJT 31(3):342-372
(2012)Isostearyl Erucate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl Ethylhexanoate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl glucoside 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 32 (S3): 22-48,
2013Isostearyl Glyceryl Ether 1 0.001 to 0.02% IJT 32 (S3): 5-21,
2013Isostearyl Hydroxystearate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Isostearyl Isononanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isostearyl Isostearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isostearyl Laurate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isostearyl Linoleate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Isostearyl Myristate 1 not in use at the time* safe for use in cosmetics whenformulated to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Isostearyl Neopentanoate 1 up to 14% safe for use in cosmetics whenformulated to be non-irritating
JACT 4(3):1-22,1985 confirmed
09/03 IJT 25(S2),2006; final report03/2013 available
from CIRIsostearyl palmitate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsostearyl sebacate 1 up to 0.7% IJT 31(S1):5- 76,
2012Isotridecyl isononanoate 1 up to 51% safe for use in cosmetics when
formulated to be non-irritatingIJT 30(S3):228-269,
2011; final report03/2013 available
from CIRIsotridecyl Laurate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRIsotridecyl Myristate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingIJT
29(S3) :162-186,2010;final report 03/2013available from CIR
Isotridecyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Japan (Rhus Succedanea) Wax 1 up to 34% JACT 3 (3):1-41,1984 confirmed
06/03Jojoba Alcohol (amended) 1 up to 1% Amended Final
Report 09/08 -available from CIR
Jojoba Amino Acids 1 not in current use* IJT 33(S4):5-12,2014
Jojoba Esters (amended) 1 up to 44% Amended FinalReport 09/08 -
available from CIRJojoba oil PEG-150 esters 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Jojoba oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Juglans Regia (Walnut) Seed Oil 1 0.00003 to 0.2% Final report 03/11available from CIR
Juniperus Communis Fruit Extract 1 IJT 20(S2):41- 56,2001
Juniperus Oxycedrus Fruit Extract 1 IJT 20(S2):41-56,2001
Juniperus Oxycedrus Tar 1 IJT 20(S2):41-56,2001
Juniperus Phoenicea Gum Extract 1 IJT 20(S2):41-56,2001
Juniperus Virginiana Wood Extract 1 IJT 20(S2):41 -56,2001
Kaolin 1 up to 100% IJT 22(S1):37-102,2003
Kefiran 1 Final report 03/2014available from CIR
Keratin Amino Acids 1 IJT 33(S4):5-12,2014
Kojic Acid 1 up to 1% IJT 29 (S4): 244-273,2010
Lactamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/11 available from
CIR
Lactic Acid 1 safe for use in cosmeticproducts at concentrations
<=10%, at final formulationpH >=3.5, when formulated
to avoid increasing sunsensitivity or when directionsfor use include the daily use
of sun protection. Theseingredients are safe foruse in salon products at
concentrations <=30%, atfinal formulation pH >=3.0,
in products designed forbrief, discontinuous use
followed by thorough rinsingfrom the skin, when applied
by trained professionals,and when application is
IJT 17(S1):1-242,1998
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
accompanied by directions forthe daily use of sun protection.
Lactitol 1 Final report 03/2014available from CIR
Lactose 1 Final report 03/2014available from CIR
Lactulose 1 not in current use * Final report 03/2014available from CIR
Laneth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laneth-10 Acetate 1 not in current use * JACT 1(4):1-23,1982 confirmed
02/02 IJT24(S1):56-59, 2005
Laneth-15 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laneth-16 1 up to 2% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(4):1-23,1982 confirmed
02/02 IJT24(S1):56-59,
2005;IJT31(S2):169-244
(2012)Laneth-20 1 safe for use in cosmetics
when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Laneth-25 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laneth-40 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laneth-5 1 up to 2% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(4):1-23,1982 confirmed
02/02 IJT24(S1):56-59, 2005;IJT 31(S2):169-244
(2012)Laneth-50 1 safe for use in cosmetics
when formulatedto be non- irritating
IJT 31(S2):169-244(2012)
Laneth-60 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Laneth-75 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laneth-9 Acetate 1 not in current use * JACT 1 (4):1-23,1982 confirmed
02/02 IJT24(S1):56-59, 2005
Lanolin 1 up to 37% JEPT 4(4):63-92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Lanolin Acid 1 up to 10% JEPT 4(4):63-92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Lanolin Alcohol 1 up to 4% JEPT 4(4):63 -92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Lanolinamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Lanolin Oil 1 up to 65% JEPT 4(4):63-92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Lanolin Wax 1 up to 25% JEPT 4(4):63-92,1980 confirmed
02/03 IJT24(S1):2-10, 2005
Lapyrium Chloride 1 0.03% in a body wash JACT 10(1):87-97,1991
Lard 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/
pesticide contamination40ppm with 10ppm for
any specific residue
IJT 20(S2):57-64,2001
Lard Glyceride 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/
pesticide contamination
IJT 20(S2):57-64,2001
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
40ppm with 10ppm forany specific residue
Lard Glycerides 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/
pesticide contamination40ppm with 10ppm for
any specific residue
IJT 20(S2):57-64,2001
L-Ascorbic Acid 1 up to 10% IJT 24(2):51-111,2005
Lauramide/Myristamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Lauramide DEA (amended) 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
JACT 5(5):415-54,1986 (originalreport); IJT 32
(S1):36-58, 2013
Lauramide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Lauramidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Lauramidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Lauramine 1 JACT 14(3):196-203,1995
Lauramine Oxide 1 safe for use in rinse-off products; but 3.7%for leave-on products
JACT 13(3):231-45,1994 confirmed
09/09; IJT30(S2):73-127, 2011
Laureth-1 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-11 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-12 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-13 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-14 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-15 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-16 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-2 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-20 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-21 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-23 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-25 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Laureth-30 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-38 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-4 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-40 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-50 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-6 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-8 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Laureth-9 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Lauric Acid 1 up to 25% JACT 6(3):321-401,1987 confirmed
06/05 IJT 25(S2),2006
Lauriminodipropionic Acid 1 not in use at the time* Final amended report12/11
Lauroyl arginine 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Lauroyl collagen amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Lauroyl Ethyltrimonium methosulfate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S3): 296-341(2012)
Lauroyl glutamic acid 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Lauroyl lysine 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 12/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Lauroyl proline 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Lauroyl Sarcosine 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Lauroyl silk amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Laurtrimonium bromide 1 safe for use when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Laurtrimonium chloride 1 safe for use when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Lauryl/Myristyl Benzoate 1 not in use at the time* IJT 31(3):342-372(2012)
Lauryl Acrylate/VA Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Lauryl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Lauryl betaine 1 0.015-8.8% safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2014available from CIR
Lauryl Cocoate (amended) 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT 30(S1):5S-16S;final report 03/2013available from CIR
Lauryl dimethicone/polyglycerin-3 crosspolymer 1 2% Final report 09/12available from CIR
Lauryl dimethicone PEG-15 crosspolymer 1 not in current use* Final report 09/12available from CIR
Lauryl ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Lauryl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
Lauryl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012
Lauryl Isopentyl-PEG/PPG-18/18 Methicone* 1 Final report 12/2014available from CIR
Lauryl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Lauryl Lactate 1 IJT 17(S1):1-242,1998
Lauryl Laurate 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Lauryl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Lauryl Methacrylate/Glycol Dimethacrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Lauryl Methacrylate/Sodium Methacrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Lauryl Myristate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Lauryl Oleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Lauryl Palmitate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Lauryl PEG/PPG-18/18 Methicone 1 Final report 12/2014available from CIR
Lauryl PEG-10 Methyl Ether Dimethicone* 1 Final report 12/2014available from CIR
Lauryl PEG-10 Tris(trimethylsiloxy)silylethyl Dimethicone* 1 Final report 12/2014available from CIR
Lauryl PEG-8 Dimethicone 1 Final report 12/2014available from CIR
Lauryl PEG-8 PPG-8 Dimethicone* 1 Final report 12/2014available from CIR
Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone 1 Final report 12/2014available from CIR
Lauryl Phosphate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Lauryl polydimethylsiloxyethyl dimethicone/bis-vinyldimethicone crosspolymer
1 not in current use* Final report 09/12available from CIR
Lauryl Polyglyceryl-3 PolydimethylsiloxyethylDimethicone*
1 Final report 12/2014available from CIR
Lauryl Stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Lecithin 1 safe as used in rinse-offproducts; but 15% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data to
IJT 20(S1):21-45,2001
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
determine safety in productswhere these ingredientsare likely to be inhaled.
Lecithinamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Leucine 1 0.0009 to 0.001% IJT 32(S4):41-64,2013
Levan 1 not in current use* Final report 09/12available from CIR
Lignoceryl Erucate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Limnanthes Alba (Meadowfoam) Seed Oil 1 0.002 to 74% Final report 03/11available from CIR
Linoleamide DEA (amended) 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
JACT 5(5):415-454,1986 (originalreport); IJT 32
(S1):36-58, 2013
Linoleamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Linoleamidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Linseed Acid 1 concentration not reported* Final report 03/11available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Linseed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Linum Usitatissimum (Linseed) Oil 1 0.001 to 10% Final report 03/11available from CIR
Lithium Magnesium Silicate 1 not in current use* IJT 22(S1):37-102,2003
Lithium Magnesium Sodium Silicate 1 not in current use* IJT 22(S1):37-102,2003
Lithium Stearate 1 up to 3% JACT 1(2):143-177,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Locust bean hydroxypropyltrimonium chloride 1 0.4% in rinse- off Final report 03/12available from CIR
Luffa Cylindrica Seed Oil 1 up to 0.01% Final report 03/11available from CIR
Lupine amino acids 1 IJT 33(S4):5-12,2014
Lupinus Albus Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR
Lupinus Albus Seed Oil 1 concentration not reported* Final report 03/11available from CIR
Lycium Barbarum Amino Acids 1 not in current use* IJT 33(S4):5-12,2014
Lycium Barbarum Seed Oil 1 concentration not reported* Final report 03/11available from CIR
Lysine 1 1.0 x 10-7 to 0.7% IJT 32(S4):41-64,2013
Lysine HCl 1 0.00003 to 0.6% IJT 32(S4):41-64,2013
Macadamia Integrifolia Seed Oil 1 0.00006 to 5% Final report 03/11available from CIR
Macadamia Ternifolia Seed Oil 1 0.0003 to 30% Final report 03/11available from CIR
Macadamia ternifolia seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Magnesium/TEA-Coco-Sulfate 1 not in current use* safe as used when formulatedto be non-irritating.
These ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be formed.
IJT 32(S1):59-83,2013
Magnesium Acetate 1 0.02 to 0.03% IJT 31 (S1):112-136,2012
Magnesium Aluminum Silicate 1 up to 5% IJT 22 (S1):37-102,2003
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Magnesium Ascorbate 1 not in current use* IJT 24(2):51-111,2005
Magnesium Ascorbyl Phosphate 1 up to 3% IJT 24(2):51-111,2005
Magnesium Aspartate 1 0.00005 to 0.1% IJT 32(S4):41-64,2013
Magnesium Benzoate 1 not in use at the time* Final amended report10/11 available from
CIRMagnesium citrate 1 0.01 to 2% IJT 33 (S2): 16 -46,
2014Magnesium Coceth Sulfate 1 safe in the present practices of
use and concentration whenformulated to be non-irritating
IJT29(S3) :151-161,2010
Magnesium Cocoate (amended) 1 concentration not reported* IJT 30(S1):5S-16SMagnesium Coco-Sulfate 1 not in current use* IJT 29(S2): 115-132,
2010Magnesium Glycinate 1 not in current use* IJT 32(S4):41-64,
2013Magnesium Isododecylbenzenesulfonate (amended) 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 29 (S4) 288-305,
2010Magnesium laureth-3 sulfosuccinate 1 safe in the present practices of
use and concentration whenformulated to be non-irritating
Final report 03/12available from CIR
Magnesium Laureth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Magnesium Myristate 1 up to 10% IJT 29(S3):162-186,2010
Magnesium Oleth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Magnesium palmitoyl glutamate 1 not in current use* safe for use in cosmeticswhen formulated
to be non- irritating
Final report 12/2013available from CIR
Magnesium PCA 1 safe as used; shouldnot be used in cosmetic
products in which N-nitrosocompounds can be formed
Final report 12/2014available from CIR
Magnesium Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Magnesium Silicate 1 not in current use* IJT 22(S1):37-102,2003
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Magnesium Stearate 1 up to 8% JACT 1(2):143-177, 1982
confirmed 11/01 IJT22(S1):1-35, 2003
Magnesium Sulfate 1 Final report 06/2014available from CIR
Magnesium Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes
and colors; safe at 15.2%(as thioglycolic acid);
hairdressers should avoidskin contact and minimizeconsumer skin exposure
IJT 28(S3):68-133,2009
Magnesium Trisilicate 1 not in current use* IJT 22(S1):37-102,2003
Magnisium Myreth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Maleic Acid 1 up to 0.004% as a pH adjuster safe for use as a pH adjuster;fragrance use not addressed
IJT 26(S2):125-130,2007
Malic Acid 1 safe for use as pH adjusters;insufficient data to support
safety for other uses
IJT 20(S1):47-55,2001
Malonic Acid 1 not in current use* IJT 31 (S1):5-76,2012
Maltitol 1 up to 15% Final report 09/08available from CIR
Maltitol Laurate 1 not in current use* Final report 09/08available from CIR
Maltose 1 Final report 03/2014available from CIR
m-Aminophenol 1 up to 5% JACT 7(3):279-333,1988 confirmed
09/05Manganese citrate 1 not in current use* IJT 33 (S2): 16-46,
2014Manganese tripeptide-1 1 not in current use* Final report 06/2014
available from CIRMangifera Indica (Mango) Seed Butter 1 0.0005 to 3% Final report 03/11
available from CIRMangifera Indica (Mango) Seed Oil 1 0.003 to 6% Final report 03/11
available from CIRMango Seed Oil PEG-70 esters 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Mannose 1 Final report 03/2014available from CIR
m-Cresol and o-Cresol 1 up to 0.5% IJT 25 (S1):29-127,2006 (Amended
Report)MEA-benzoate 1 safe in the present practices
of use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
MEA-cocoate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Meadowfoamamidopropyl Betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
MEA-laureth-6 carboxylate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
MEA-laureth sulfate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
MEA-lauryl sulfate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmetic
Final amended report03/12 available from
CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
products in which N-nitrosocompounds may be formed
MEA-PPG-8 steareth-7 carboxylate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
MEA-PPG laureth-6 carboxylate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
MEA-Salicylate (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)
when formulated to be non-irritating; should not be
used in cosmetic products inwhich N-nitroso compoundsmay be formed; when usedas a salicylate ingredient,safe when formulated to
avoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
Final amended report03/12 available fromCIR; IJT 22(3):1-108
(original salicylatereport)
MEA-sulfite 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
MEA-tallowate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmetic
Final amended report03/12 available from
CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
products in which N-nitrosocompounds may be formed
MEA-undecylenate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Melamine/Formaldehyde Resin (now calledPolyoxymethylene Melamine)
0 JACT 14(5):373-85,1995
Melibiose 1 Final report 03/2014available from CIR
Mentha Piperita (Peppermint) Leaf 1 safe as used, except that theconcentration of pulegone
should not exceed 1%
IJT 20(S3):61-73,2001
Mentha Piperita (Peppermint) Leaf Extract 1 safe as used, except that theconcentration of pulegone
should not exceed 1%
IJT 20(S3):61-73,2001
Mentha Piperita (Peppermint) Leaf Water 1 safe as used, except that theconcentration of pulegone
should not exceed 1%
IJT 20(S3):61-73,2001
Mentha Piperita (Peppermint) Oil 1 safe as used, except that theconcentration of pulegone
should not exceed 1%
IJT 20(S3):61-73,2001
Methacrylic Acid 1 safe as a nail primer in thepresent practices of use bytrained professionals, but
insufficient data to supportretail use by consumers
IJT 24(S5):33-51,2005
Methacrylic Acid/PEG-6 Methacrylate/PEG-6Dimethacrylate Crosspolymer
1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Methacrylic Acid\ Styrene\ VP Copolymer 1 Final report 09/2014available from CIR
Methacryloyl Ethyl Betaine/Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Methenamine 1 0.16%; but should notbe used in products
intended to be aerosolized
JACT 11(4):531-58,1992
Methicone 1 up to 5% IJT 22(S2):11-35,2003
Methionine 1 0.0001 to 0.07% IJT 32(S4):41-64,2013
Methoxydiglycol Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
IJT 24(S5):53-100,2005
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
Methoxyisopropanol 1 up to 35%in nail careproducts; fragranceuse not addressed
IJT 27(S2): 25-29,2008
Methoxyisopropyl Acetate 1 not in current use* IJT 27(S2): 25-29,2008
Methoxy PEG/PPG-25/4 Dimethicone 1 Final report 12/2014available from CIR
Methoxy PEG-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Methoxy PEG-100 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Methoxy PEG-11 Methoxy PPG-24 Dimethicone* 1 Final report 12/2014available from CIR
Methoxy PEG-13 Ethyl Polysilsesquioxane* 1 Final report 12/2014available from CIR
Methoxy PEG-16 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Methoxy PEG-25 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Methoxy PEG-40 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Methoxy PEG-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Methyl Acetate 1 10 to 60% IJT 31(S1):112-136,2012
Methyl Alcohol 1 safe for use as a denaturant IJT 20(S1):57-85,2001
Methylbenzethonium Chloride 1 0.5% skin; 0.02% eye JACT 4(5):65-106,1985 confirmed
03/04 IJT 25(S2),2006
Methyl Benzoate 1 0.0005 to 0.3% IJT 31(3):342 -372(2012)
Methylcellulose (amended) 1 up to 20% Amended safetyassessment 03/09 -
Available from CIRJACT 5(3)1-59, 1986
(original report)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Methylchloroisothiazolinone (with Methylisothiazolinone) 1 rinse-off 15 ppm;leave-on 7.5 ppm
JACT 11(1):75-128,1992
Methyl Cocoate (amended) 1 up to 0.06% IJT 30 (S1):5S-16SMethyldibromo Glutaronitrile 1 leave-on 0.025% JACT 15(2):140-65,
1996Methylene Chloride 1 brief, discontinuous use only 7 JACT 7(6):741-835,
19887Methylene Glycol 1 1 safe for use in cosmetics
when formulated toensure use at the minimaleffective concentration,but in no case should theformalin concentration
exceed 0.2% (w/w), whichwould be 0.074% (w/w)
calculated as formaldehydeor 0.118% (w/w) calculatedas methylene glycol; safein the present practices ofuse and concentration in
nail hardening products ---unsafe in the present practices
of use and concentrationin hair smoothing products
IJT 32(S4):5-32,2013
Methyl Ethylcellulose 1 not in use at the time* Amended SafetyAsessment 03/09
available from CIRMethyl Gluceth-10 1 Final report 09/2013
available from CIRMethyl Gluceth-20 1 Final report 09/2013
available from CIRMethyl glucose caprylate/caprate 1 Final report 09/2013
available from CIRMethyl glucose dioleate 1 Final report 09/2013
available from CIRMethyl glucose isostearate 1 Final report 09/2013
available from CIRMethyl glucose laurate 1 Final report 09/2013
available from CIRMethyl glucose sesquicaprylate/sesquicaprate 1 Final report 09/2013
available from CIRMethyl glucose sesquicocoate 1 Final report 09/2013
available from CIRMethyl glucose sesquiisostearate 1 Final report 09/2013
available from CIRMethyl glucose sesquilaurate 1 Final report 09/2013
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Methyl glucose sesquioleate 1 Final report 09/2013available from CIR
Methyl glucose sesquistearate 1 Final report 09/2013available from CIR
Methyl Glycolate 1 safe for use in cosmeticproducts at concentrations
<=10%, at final formulationpH >=3.5, when formulated
to avoid increasing sunsensitivity or when directionsfor use include the daily use
of sun protection. Theseingredients are safe foruse in salon products at
concentrations <=30%, atfinal formulation pH >=3.0,
in products designed forbrief, discontinuous use
followed by thorough rinsingfrom the skin, when applied
by trained professionals,and when application is
accompanied by directions forthe daily use of sun protection.
IJT 17(S1):1-242,1998
Methyl Glycyrrhizate 1 not in current use* IJT 26(S2):79-112,2007
Methyl Hydroxyethylcellulose 1 not in use at the time* Amended SafetyAssesment 03/09
available from CIRMethyl Isobutyl Ketone (aka MIBK) 1 safe as used in nail polish
removers and up to 4%as an alcohol denaturant
IJT 23(S1):29-57,2003
Methylisothiazolinone (alone) 1 safe at concentrations upto 100 ppm and safe foruse in leave-on cosmetic
products when formulatedto be non-sensitizingm
which may be determinedbased on a quantitativerisk assessment (QRA).
IJT 29 (S3): 187-213,2010; Final report09/2014 available
from CIR
Methylisothiazolinone (with Methylchloroisothiazolinone) 1 rinse-off 15 ppm;leave-on 7.5 ppm
JACT 11(1):75-128,1992
Methyl Lactate 1 safe for use in cosmeticproducts at concentrations
<=10%, at final formulationpH >=3.5, when formulated
to avoid increasing sunsensitivity or when directionsfor use include the daily use
IJT 17(S1):1-242,1998
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
of sun protection. Theseingredients are safe foruse in salon products at
concentrations <=30%, atfinal formulation pH >=3.0,
in products designed forbrief, discontinuous use
followed by thorough rinsingfrom the skin, when applied
by trained professionals,and when application is
accompanied by directions forthe daily use of sun protection.
Methyl Methacrylate/Glycol Dimethacrylate Crosspolymer 1 up to 3% IJT 30 (1): 54-65,2011
Methyl Methacrylate Crosspolymer 1 up to 14% IJT 30 (1): 54-65,2011
Methyl Myristate 1 not in use at the time* IJT29(S3) :162-186,2010
Methylparaben (amended) 1 up to 0.4% if used alone;parabens mixture up to 0.8%
IJT 27(S4): 1-82,2008 JACT
3(5):147-209, 1984(original report)
Methyl Pelargonate 1 not in current use* Final report 06/10available from CIR
Methyl Ricinoleate 1 not in current use* IJT 26(S3) 2007Methyl Salicylate 1 safe when formulated to
avoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Methylstyrene/Vinyltoluene Copolymer 1 Final report 09/2014available from CIR
Methyl Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes
and colors; safe at 15.2%(as thioglycolic acid);
hairdressers should avoidskin contact and minimizeconsumer skin exposure
IJT 28(S3):68-133,2009
MIBK (aka Methyl Isobutyl Ketone) 1 safe as used in nail polishremovers and up to 4%as an alcohol denaturant
IJT 23(S1):29-57,2004
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Microbial Polysaccharide Gums (see CIR Report with samename)
Final report 09/12available from CIR
Microcrystalline Cellulose (amended) 1 up to 57% Amended safetyassessment 03/09 -
Available from CIRMicrocrystalline Wax 1 up to 50% JACT 3(3):43- 99,
1984 confirmed06/03 IJT
24(S1):67-74, 2005Milkamidopropyl betaine 1 safe for use in cosmetics
when formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Milk amino acids 1 IJT 33(S4):5-12,2014
Minkamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Minkamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Minkamidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,
which may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Mink Oil (Amended) 1 up to 3% IJT 24(S3):57-64,2005 IJT
17(S4):71-82, 1998(Original Report)
mink oil PEG-13 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
MIPA-Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 29 (S4) 288-305,2010
Mixed Cresols (amended) 1 IJT 25(S1):29-127,2006
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Mixed Isopropanolamines 1 safe for use in cosmeticproducts; but should not beused in products containing
N-nitrosating agents
JACT 6(1):53-76,1987 confirmed
12/04 IJT 25(S2),2006
Monoethanolamine (now Ethanolamine) 1 safe for use in rinse-offproducts; but should not beused in leave-on products
JACT 2(7):183-235,1983
Monosodium citrate 1 0.004 to 5% IJT 33 (S2): 16-46,2014
Montan Wax 1 up to 11% JACT 3(3):43-99,1984 confirmed
06/03 IJT24(S1):67-74, 2005
Montmorillonite 1 not in current use* IJT 22 (S1):37-102,2003
Morinda Citrifolia Seed Oil 1 not in current use* Final report 03/11available from CIR
Moringa Oleifera Seed Oil 1 up to 0.001% Final report 03/11available from CIR
Moringa Pterygosperma Seed Oil 1 0.003 to 3% Final report 12/10available from CIR
Morpholine 1 JACT 8(4):707-748,1989
m-Phenylenediamine 1 10% in hair dyes IJT 16(S1):59-116,1997
m-Phenylenediamine Sulfate 1 10% in hair dyes IJT16(S1):59-116,1997
Myreth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Myreth-2 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Myreth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Myreth-4 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Myreth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Myristamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int the
IJT 32(S1):36-58,2013
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
CIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
Myristamide MEA (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Myristamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Myristamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Myristic Acid 1 up to 50% JACT 6(3):321-401,1987 confirmed
06/05 IJT 25(S2),2006; IJT 29 (S3):
162-186, 2010Myristoyl ethyltrimonium methosulfate 1 Safe in the present practices of
use and concentration, whenformulated to be non-irritating
IJT 31(S3): 296-341(2012)
Myristoyl glutamic acid 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Myristoyl hexapeptide-12 1 not in current use* Final report 06/2014available from CIR
Myristoyl pullulan 1 not in current use* Final report 09/12available from CIR
Myristoyl Sarcosine 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Myristoyl tripeptide-1 1 not in current use* Final report 06/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Myristyl Acetate 1 not in use at the time* IJT 31(S1):112-136,2012
Myristyl Alcohol 1 up to 5% JACT 7(3):359-413,1988 confirmed
12/05Myristyl Betaine 1 up to 0.84% safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2014
available from CIRMyristyl Ethylhexanoate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRMyristyl Glucoside 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 32 (S3): 22-48,
2013Myristyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,
2012Myristyl Isostearate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRMyristyl Lactate (Amended) 1 safe for use in cosmetic
products at concentrations<=10%, at final formulationpH >=3.5, when formulated
to avoid increasing sunsensitivity or when directionsfor use include the daily use
of sun protection. Theseingredients are safe foruse in salon products at
concentrations <=30%, atfinal formulation pH >=3.0,
in products designed forbrief, discontinuous use
followed by thorough rinsingfrom the skin, when applied
by trained professionals,and when application is
accompanied by directions forthe daily use of sun protection.
IJT 17(S1):1-242,1998 JACT
1(2):97-107, 1982(Original Report)
Myristyl Laurate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Myristyl Myristate 1 up to 17% safe for use in cosmetics whenformulated to be non-irritating
JACT 1(4):55-80,1982 confirmed
06/02 IJT24(S1):63-67, 2005;final report 03/2013available from CIR
Myristyl Neopentanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Myristyl Phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Myristyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Myristyl Stearate 1 up to 4% safe for use in cosmetics whenformulated to be non-irritating
JACT 4(5):107-46,1985 confirmed
06/03 IJT24(S1):21-25, 2005;final report 03/2013available from CIR
Myrtrimonium bromide 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
N,N-Bis(2-Hydroxyethyl)-p- Phenylenediamine Sulfate 1 up to 5% JACT 11(1):129-43,1992
n-Butane (aka Butane) 1 up to 92% JACT 1 (4):127-42,1982 confirmed
06/02 IJT24(S1):52-55, 2005
n-Butyl Alcohol 1 up to 15% in nail products, upto 0.002% in other products
IJT 27(S2): 53-69,2008 JACT
6(3):403-25, 1987(Original Report)
Neopentyl Glycol Dicaprylate/Dipelargonate/Dicaprate 1 not in use at the time* Final report 06/10available from CIR
Neopentyl glycol diisononanoate 1 1% IJT 30 (S3):228-269,2011
Niacin 1 Niacin <= 0.1%;Niacinamide <=3%
IJT 24(S5):1-31,2005
Niacinamide 1 Niacin <= 0.1%;Niacinamide <=3%
IJT 24(S5):1-31,2005
Nitrocellulose 1 Final report 06/13available from CIR
Noneth-8 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Nonoxynol-1 1 safe as used in rinse-offs;safe at 5% in leave- ons
IJT 18(S1):11-31,1999
Nonoxynol-10 1 up to 25% JACT 2(7):35-60,1983
Nonoxynol-12 1 up to 5% JACT 2(7):35-60,1983
Nonoxynol-14 1 up to 1% JACT 2(7):35-60,1983
Nonoxynol-15 1 <= 0.1% JACT 2(7):35-60,1983
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Nonoxynol-2 1 safe as used in rinse-offs;safe at 5% in leave-ons
IJT 18(S1):11-31,1999 JACT
2(7):35-60, 1983(Original Report)
Nonoxynol-3 1 safe as used in rinse-offs;safe at 5% in leave- ons
IJT 18(S1):11-31,1999
Nonoxynol-30 1 <= 0.1% JACT 2(7):35-60,1983
Nonoxynol-4 1 safe as used in rinse-offs;safe at 5% in leave- ons
IJT 18(S1):11-31,1999 JACT
2(7):35-60, 1983(Original Report)
Nonoxynol-40 1 not in current use* JACT 2 (7):35-60,1983
Nonoxynol-5 1 safe as used in rinse-offs;safe at 5% in leave- ons
IJT 18(S1):11-31,1999
Nonoxynol-50 1 up to 25% JACT 2(7):35-60,1983
Nonoxynol-6 1 safe as used in rinse-offs;safe at 5% in leave- ons
IJT 18(S1):11-31,1999
Nonoxynol-7 1 safe as used in rinse-offs;safe at 5% in leave- ons
IJT 18(S1):11-31,1999
Nonoxynol-8 (Amended) 1 safe as used in rinse-offs;safe at 5% in leave-ons
IJT 18(S1):11-31,1999 JACT
2(7):35-60, 1983(Original Report)
Nonoxynol-9 1 up to 50% JACT 2(7):35-60,1983
Nonyl Acetate 1 0.0004% IJT 31(S1):112-136,2012
N-Phenyl-p-Phenylenediamine 1 up to 1.7% as the free base JACT 13(5):374-94,1994
N-Phenyl-p-Phenylenediamine HCl 1 up to 1.7% as the free base JACT 13(5):374-94,1994
N-Phenyl-p-Phenylenediamine Sulfate 1 up to 1.7% as the free base JACT 13(5):374-94,1994
Nylon-10/10 1 not in current use* IJT 33(S4):47-60,2014
Nylon-11 1 IJT 33(S4):47-60,2014
Nylon-12 1 IJT 33(S4):47-60,2014
Nylon-12/6/66 1 not in current use* IJT 33(S4):47-60,2014
Nylon-6 1 IJT 33(S4):47-60,2014
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Nylon 6/12 1 IJT 33(S4):47-60,2014
Nylon-611 1 not in current use* IJT 33(S4):47-60,2014
Nylon-66 1 IJT 33(S4):47-60,2014
o-aminophenol 1 up to 1% JACT 7(3):279-333,1988 confirmed
09/05Oatamide MEA 1 safe in the present practices
of use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Oatamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Oatamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014
Oat amino acids 1 IJT 33(S4):5-12,2014
Octacosanyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012
Octacotrimonium chloride 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S3): 296-341(2012)
Octadecyl D-glucoside 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 32 (S3): 22-48,2013
Octododecyl Avocadoate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octododecyl Beeswax 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octododecyl Behenate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octododecyl Benzoate 1 3 to 4% IJT 31(3):342- 372(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Octododecyltrimonium chloride 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Octoxynol-1 1 up to 30% in permanentwaves, lower for other uses
safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Octoxynol-10 1 up to 25% in hair bleaches IJT 23(S1):59-111,2004
Octoxynol-11 1 up to 1% IJT 23(S1):59-111,2004
Octoxynol-12 1 not in current use* IJT 23 (S1):59-111,2004
Octoxynol-13 1 up to 2% IJT 23(S1):59-111,2004
Octoxynol-16 1 not in current use* IJT 23 (S1):59-111,2004
Octoxynol-20 1 not in current use* IJT 23 (S1):59-111,2004
Octoxynol-20 Carboxylic Acid 1 not in current use* IJT 23(S1):59-111,2004
Octoxynol-25 1 not in current use* IJT 23 (S1):59-111,2004
Octoxynol-3 1 not reported* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Octoxynol-30 1 up to 2% IJT 23(S1):59-111,2004
Octoxynol-33 1 not in current use* IJT 23 (S1):59-111,2004
Octoxynol-40 1 up to 0.02% IJT 23(S1):59-111,2004
Octoxynol-5 1 not reported* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Octoxynol-6, -7, and -8 1 not in current use* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Octoxynol-7 1 not in current use* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Octoxynol-70 1 not in current use* IJT 23 (S1):59-111,2004
Octoxynol-8 1 not in current use* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Octoxynol-9 1 up to 5% IJT 23(S1):59-111,2004
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Octoxynol-9 Carboxylic Acid 1 not in current use* IJT 23(S1):59-111,2004
Octyldecyl Oleate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldecyl Phosphate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 09/2014available from CIR
Octyldodecanol 1 up to 85% JACT 4(5):1-29,1985 confirmed
03/04; IJT 25(S2),2006
Octyldodeceth-10 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodeceth-16 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodeceth-2 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodeceth-20 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodeceth-25 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodeceth-30 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodeceth-5 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 31(S2):169-244(2012)
Octyldodecyl Cocoate (amended) 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 30(S1):5S-16S;final report 03/2013available from CIR
Octyldodecyl Erucate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Ethylhexanoate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Glucoside 1 Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 32 (S3): 22-48,2013
Octyldodecyl Hydroxystearate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Octyldodecyl Isostearate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Meadowfoamate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Myristate 1 up to 21% Safe as used in cosmeticswhen formulated
to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Octyldodecyl Neodecanoate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Neopentanoate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Octyldodecanoate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Oleate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Olivate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Ricinoleate 1 up to 5% Safe as used in cosmeticswhen formulated
to be non-irritating
IJT 26(S3) 2007;final report 03/2013available from CIR
Octyldodecyl Safflowerate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Stearate 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Octyldodecyl Stearoyl Stearate (amended) 1 up to 15% IJT 24(S3):65-74,2005 IJT
20(S3):51-59, 2001(Original report)
o-Cymen-5-ol (Amended) 1 up to 0.5% IJT 25 (S1):29-127,2006 JACT
3(3):131-55, 1984(Original Report)
Oenothera Biennis (Evening Primrose) Oil 1 0.00002 to 58% Final report 03/11available from CIR
Olea Europaea (Olive) Fruit Oil 1 0.0005 to 100% Final report 03/11available from CIR
Olea Europaea (Olive) Husk Oil 1 not in current use* Final report 03/11available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Olea Europaea (Olive) Oil Unsaponifiables 1 0.0001 to 3% Final report 03/11available from CIR
Oleamide DEA (amended) 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
JACT 5(5):415-454,1986 (originalreport); IJT 32
(S1):36-58, 2013
Oleamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Oleamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Oleamidopropyl dimethylamine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Oleic Acid 1 up to 50% JACT 6(3):321-401,1987 confirmed
06/05 IJT 25(S2),2006
Oleoyl Sarcosine 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Oleoyl Tyrosine 1 Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 12/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Oleth-10 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-100 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-106 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-11 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-12 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-15 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-16 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-2 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-20 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-23 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-24 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-25 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Oleth-3 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-30 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-35 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-4 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-40 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-44 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-45 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-5 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-50 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-6 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-7 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-8 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Oleth-82 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleth-9 1 safe as used in cosmeticswhen formulated
to be non- irritating
IJT 18(S2):17-24,1999; IJT
31(S2):169-244(2012)
Oleyl Alcohol 1 up to 62% JACT 4(5):1-29,1985 confirmed
03/04 IJT 25(S2),2006
Oleyl Arachidate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Oleyl Betaine 1 up to 23.7% safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2014available from CIR
Oleyl Erucate 1 safe as used in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Oleyl Ethyl Phosphate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 09/2014available from CIR
Oleyl Glyceryl Ether 1 not in current use* IJT 32 (S3): 5-21,2013
Oleyl Linoleate 1 safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Oleyl Myristate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Oleyl Oleate 1 safe as used in cosmeticswhen formulated
to be non- irritating
Final report 03/2013available from CIR
Oleyl Phosphate 1 not in current use* Safe as used in cosmeticswhen formulated
to be non-irritating
Final report 09/2014available from CIR
Oleyl Stearate 1 not in current use* safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Olivamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int the
IJT 32(S1):36-58,2013
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
CIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
Olivamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Olivamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Olivamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Olive Acid 1 not in use at the time* Final report 03/11available from CIR
Olive Oil PEG-10 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Olive oil PEG-6 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Olive Oil PEG-7 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Olive Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Olive Oil Propylene Glycol Esters* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
Orbignya Cohune Seed Oil 1 concentration not reported* Final report 03/11available from CIR
Orbignya Oleifera Seed Oil 1 0.0009 to 27% Final report 03/11available from CIR
orbignya oleifera seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Orbignya Speciosa Kernel Oil 1 0.5 to 0.9% Final report 03/11available from CIR
Oryza Sativa (Rice) Bran 1 concentraton not reported* IJT 25(S2):91-120,2006
Oryza Sativa (Rice) Bran Acid 1 not in current use* These rice derivedingredients as used in
products should not contain
IJT 25(S2):91-120,2006
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
significant levels of pesticideresidues or heavy metals
Oryza Sativa (Rice) Bran Extract 1 concentraton not reported* IJT 25(S2):91-120,2006
Oryza Sativa (Rice) Bran Oil 1 0.0003 to 78% These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
Final amended report03/11 availablefrom CIR; IJT
25(S2):91-120, 2006(original)
Oryza Sativa (Rice) Bran Wax 1 concentraton not reported* IJT 25(S2):91-120,2006
Oryza Sativa (Rice) Extract 1 not in current use* These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
IJT 25(S2):91-120,2006
Oryza Sativa (Rice) Germ Oil 1 0.003 to 3% These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
Final amended report03/11 availablefrom CIR; IJT
25(S2):91-120, 2006(original)
Oryza Sativa (Rice) Germ Powder 1 concentraton not reported* IJT 25(S2):91-120,2006
Oryza Sativa (Rice) Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Oryza Sativa (Rice) Starch 1 1 to 97% These rice derivedingredients as used in
products should not containsignificant levels of pesticide
residues or heavy metals
IJT 25(S2):91-120,2006
Oxidized beta-glucan 1 not in current use* Final report 09/12available from CIR
Oxyquinoline and Oxyquinoline Sulfate (Amended) 1 Safe for use as stabilizers forhydrogen peroxide in rinse-off hair products; insufficient
data for leave-on uses
IJT 25(S1):1-9, 2006JACT 11(4):497-507,1992 (original report)
Ozokerite 1 up to 22% JACT 3(3):43-99,1984 confirmed
06/03Palm (Elaeis Guineensis) Oil 1 up to 2% IJT 19 (S2):7-28,
2000Palm Acid 1 1 to 17% Final report 03/11
available from CIRPalmamide DEA 1 safe in the present practices
of use and concentrationwhen formulated to be non-irritating and when the levelsof free DEA do not exceed
IJT 32(S1):36-58,2013
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
Palmamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Palmamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Palmeth-2 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Palmitamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Palmitamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Palmitamidopropyl dimethylamine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Palmitic Acid 1 up to 25% JACT 6(3):321-401,1987 confirmed
06/05Palmitoyl alanine 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Palmitoyl arginine 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Palmitoyl carnitine 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Palmitoyl collagen amino acids 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 12/2013available from CIR
Palmitoyl glutamic acid 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Palmitoyl glycine 1 safe for use in cosmeticswhen formulated
to be non- irritating
Final report 12/2013available from CIR
Palmitoyl gold of pleasure amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Palmitoyl hexapeptide-12 1 Final report 06/2014available from CIR
Palmitoyl isoleucine 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
palmitoyl keratin amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
palmitoyl millet amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
palmitoyl oat amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
palmitoyl pea amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
palmitoyl proline 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
palmitoyl quinoa amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
palmitoyl silk amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Palmitoyl tetrapeptide-7 1 not in current use* Final report 06/2014available from CIR
Palm Kernel Acid 1 2 to 12% Final report 03/11available from CIR
Palm kernelamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
Final amended report09/11 available from
CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Palm kernelamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Palm kernelamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Palm Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
p-aminophenol 1 up to 1% JACT 7(3):279-333,1988 confirmed
09/05Pamitoyl ethyltrimonium methosulfate 1 safe when formulated
to be non-irritatingIJT 31(S3): 296-341
(2012)Pamitoyl tripeptide-1 1 Final report 06/2014
available from CIRPanax ginseng root 1 concentration not reported* Final report 09/12
available from CIRPanax ginseng root extract*** 1 0.000002 to 0.5% Final report 09/12
available from CIRPanax ginseng root oil 1 not in current use* Final report 09/12
available from CIRPanax ginseng root powder 1 concentration not reported* Final report 09/12
available from CIRPanax ginseng root protoplast 1 not in current use* Final report 09/12
available from CIRPanax ginseng root water 1 not in current use* Final report 09/12
available from CIRPanax japonicus root extract 1 not in current use* Final report 09/12
available from CIRPanax notoginseng root 1 0.0004% Final report 09/12
available from CIRPanax notoginseng root powder 1 not in current use* Final report 09/12
available from CIRPanax quinquefolium root extract 1 0.0005 to 0.002% Final report 09/12
available from CIRPanthenol 1 up to 25% JACT 6(1):139-62,
1987 confirmed12/04 IJT 25(S2),
2006
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Pantothenamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Pantothenic Acid 1 not in use at the time* JACT 6(1):139-62,1987 confirmed
12/04 IJT 25(S2),2006
Paraffin 1 0.03 to 99% JACT 3(3):43-99,1984 confirmed
06/03 IJT24(S1):67-74, 2005
Passiflora Edulis Seed Oil 1 0.0007 to 3% IJT 31(S2):169-244(2012)
Passiflora edulis seed oils PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PCA 1 safe as used; shouldnot be used in cosmetic
products in which N-nitrosocompounds can be formed
IJT 18(S2):25-34,1999; Final report12/2014 available
from CIRp-Chloro-m-Cresol (amended) 1 up to 5% IJT 25 (S1):29-127,
2006 IJT16(S3):235-68,1997
(Original Report)p-Cresol (amended) 1 IJT 25(S1):29-127,
2006Peanut (Arachis Hypogaea) Flour 1 IJT 20(S2):65-77,
2001Peanut (Arachis Hypogaea) Oil 1 up to 25% IJT 20(S2):65-77,
2001Peanut Acid and Peanut Glycerides 1 not in current use* Final amended report
03/11 availablefrom CIR; IJT
20(S2):65-77, 2001(original)
Peanutamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Peanut Oil PEG-6 Esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG/PPG-10/2 Dimethicone* 1 Final report 12/2014available from CIR
PEG/PPG-10/2 Propylheptyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-10/3 Oleyl Ether Dimethicone* 1 Final report 12/2014available from CIR
PEG/PPG-12/16 Dimethicone* 1 Final report 12/2014available from CIR
PEG/PPG-12/18 Dimethicone* 1 Final report 12/2014available from CIR
PEG/PPG-14/2 Propylheptyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-14/4 Dimethicone 1 JACT 1(4):33-54,1982 confirmed
02/03 IJT24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG/PPG-14/7 Dimethyl Ether 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRPEG/PPG-15/15 Dimethicone 1 IJT 24(Suppl.
1):1-102, 2005;Final report 12/2014
available from CIRPEG/PPG-15/5 Dimethicone* 1 Final report 12/2014
available from CIRPEG/PPG-16/2 Dimethicone* 1 IJT 24(Suppl.
1):1-102, 2005;Final report 12/2014
available from CIRPEG/PPG-16/8 Dimethicone* 1 Final report 12/2014
available from CIRPEG/PPG-17/18 Dimethicone 1 JACT 1(4):33-54,
1982 confirmed02/03 IJT
24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG/PPG-17/4 Dimethyl Ether 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRPEG/PPG-18/12 Dimethicone* 1 Final report 12/2014
available from CIRPEG/PPG-18/18 Dimethicone 1 JACT 1(4):33-54,
1982 confirmed02/03 IJT
24(S1):42-44, 2005;
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Final report 12/2014available from CIR
PEG/PPG-18/6 Dimethicone* 1 Final report 12/2014available from CIR
PEG/PPG-19/19 Dimethicone 1 IJT 24(Suppl.1):1-102, 2005;
Final report 12/2014available from CIR
PEG/PPG-20/15 Dimethicone 1 JACT 1(4):33-54,1982 confirmed
02/03 IJT24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG/PPG-20/20 Dimethicone 1 IJT 24(Suppl.
1):1-102, 2005;Final report 12/2014
available from CIRPEG/PPG-20/22 Butyl Ether Dimethicone* 1 Final report 12/2014
available from CIRPEG/PPG-20/22 Methyl Ether Dimethicone* 1 Final report 12/2014
available from CIRPEG/PPG-20/23 Dimethicone 1 IJT 24(Suppl.
1):1-102, 2005;Final report 12/2014
available from CIRPEG/PPG-20/29 Dimethicone* 1 IJT 24(Suppl.
1):1-102, 2005;Final report 12/2014
available from CIRPEG/PPG-20/6 Dimethicone 1 JACT 1(4):33-54,
1982 confirmed02/03 IJT
24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG/PPG-22/22 Butyl Ether Dimethicone* 1 Final report 12/2014
available from CIRPEG/PPG-22/23 Dimethicone 1 JACT 1(4):33 -54,
1982 confirmed02/03 IJT
24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG/PPG-22/24 Dimethicone 1 IJT 24(Suppl.
1):1-102, 2005;Final report 12/2014
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG/PPG-22/40 Dimethyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-23/23 Butyl Ether Dimethicone* 1 Final report 12/2014available from CIR
PEG/PPG-23/6 Dimethicone* 1 IJT 24(Suppl.1):1-102, 2005;
Final report 12/2014available from CIR
PEG/PPG-24/18 Butyl Ether Dimethicone* 1 Final report 12/2014available from CIR
PEG/PPG-25/25 Dimethicone 1 IJT 24(Suppl.1):1-102, 2005;
Final report 12/2014available from CIR
PEG/PPG-27/14 Dimethyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-27/27 Dimethicone* 1 IJT 24(Suppl.1):1-102, 2005;
Final report 12/2014available from CIR
PEG/PPG-27/9 Butyl Ether Dimethicone* 1 Final report 12/2014available from CIR
PEG/PPG-3/10 Dimethicone* 1 IJT 24(Suppl.1):1-102, 2005;
Final report 12/2014available from CIR
PEG/PPG-3/6 Dimethyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-30/10 Dimethicone 1 Final report 12/2014available from CIR
PEG/PPG-35/40 Dimethyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-36/41 Dimethyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-4/12 Dimethicone 1 JACT 1 (4):33-54,1982 confirmed
02/03 IJT24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG/PPG-4/2 Propylheptyl Ether 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRPEG/PPG-40/2 Propylheptyl Ether 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRPEG/PPG-5/2 Methacrylate/Methacrylic Acid Crosspolymer 1 safe in the present practices of
use and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG/PPG-50/40 Dimethyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-52/32 Dimethyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-55/28 Dimethyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-6/11 Dimethicone* 1 IJT 24(Suppl.1):1-102, 2005;
Final report 12/2014available from CIR
PEG/PPG-6/2 Propylheptyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-6/4 Dimethicone* 1 Final report 12/2014available from CIR
PEG/PPG-7/12 Dimethyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-8/14 Dimethicone 1 IJT 24(Suppl.1):1-102, 2005;
Final report 12/2014available from CIR
PEG/PPG-8/26 Dimethicone* 1 Final report 12/2014available from CIR
PEG/PPG-8/2 Propylheptyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG/PPG-9/2 Dimethyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG>=4 0 because PEGs of variouschain lengths are likely to
be added to the InternationalCosmetic Ingredient
Dictionary and Handbookin the future, the CIR
Expert Panel concludedthat any PEG>=4 would be
safe for use in cosmetics
Final report 06/10available from CIR
PEG-10 1 0.1 to 0.2% Final report 06/10available from CIR
PEG-10/lauryl dimethicone crosspolymer 1 0.5 to 0.7% Final report 09/12available from CIR
PEG-100 1 not in current use* Final report 06/10available from CIR
PEG-100 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-100 hydrogenated castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-100 Lanolin 1 concentration not reported* Final amended report09/12 available from
CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-100 Stearate 1 up to 6% IJT 24(S1):1-102,2005
PEG-100 Stearate 1 up to 25% JACT 2(7):17-60,1983 confirmed
11/02 IJT24(S1):74-80, 2005
PEG-10 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-10 Cocamine 1 IJT 18(S1):11-31,1999
PEG-10 Dimethicone 1 JACT 1(4):33-54,1982 confirmed
02/03 IJT24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG-10 dimethicone/vinyl dimethicone crosspolymer 1 concentration not reported* Final report 09/12
available from CIRPEG-10 dimethicone crosspolymer 1 0.6 to 2% Final report 09/12
available from CIRPEG-10 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-10 hydrogenated castor oil isostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-10 hydrogenated castor oil triisostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-10 Hydrogenated Lanolin 1 not in current use* Final amended report
09/12 available fromCIR
PEG-10 Lanolin 1 not in current use* Final amended report09/12 available from
CIRPEG-10 Laurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-10 Methyl Ether Dimethicone 1 Final report 12/2014
available from CIRPEG-10 Olive Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-10 Polydimethylsiloxyethyl Dimethicone/bis-vinylDimethicone Crosspolymer*
1 Final report 12/2014available from CIR
PEG-10 Propylene Glycol 1 not in current use* IJT 20(S4):13-26,2001
PEG-10 Sorbitan Laurate 1 <= 10% IJT 19 (S2):43-89,2000
PEG-10 Soy Sterol 1 up to 2% IJT 23(S2):23-47,2004
PEG-10 Sunflower Glycerides 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-10 Tsubakiate Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-115M 1 not in current use* Final report 06/10available from CIR
PEG-11 Avocado Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-11 Babassu Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-11 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-11 Cocoa Butter Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-11 Methyl Ether Dimethicone 1 Final report 12/2014available from CIR
PEG-12 1 0.04 to 56% Final report 06/10available from CIR
PEG-120 Distearate 1 not in current use* IJT 19(S1):51-59,1999
PEG-120 methyl glucose dioleate 1 Final report 09/2013available from CIR
PEG-120 methyl glucose triisostearate 1 Final report 09/2013available from CIR
PEG-120 methyl glucose trioleate 1 Final report 09/2013available from CIR
PEG-120 Propylene Glycol Stearate 1 not in current use* IJT 20(S4):13-26,2001
PEG-12 Dilaurate 1 up to 25% IJT 19(S2):29-41,2000
PEG-12 Dimethicone 1 JACT 1(4):33-54,1982 confirmed
02/03 IJT24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG-12 dimethicone/bis-isobutyl PPG-20 crosspolymer 1 not in current use* Final report 09/12
available from CIRPEG-12 dimethicone/PPG-20 crosspolymer 1 not in current use* Final report 09/12
available from CIRPEG-12 dimethicone crosspolymer 1 0.3 to 2% Final report 09/12
available from CIRPEG-12 Distearate 1 up to 5% IJT 19(S1):51-59,
1999PEG-12 Laurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-12 Palm Kernel Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-12 Stearate 1 up to 1% JACT 2(7):17-60,1983 confirmed
11/02 IJT24(S1):74-80, 2005
PEG-135 1 not in current use* Final report 06/10available from CIR
PEG-13 Mink Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-13 Sunflower Glycerides 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-14 1 0.1 to 2% Final report 06/10available from CIR
PEG-14 Avocado Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-14 Dimethicone 1 JACT 1(4):33-54,1982 confirmed
02/03 IJT24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG-14 Laurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-14M 1 0.05 to 0.5% Final report 06/10
available from CIRPEG-15/lauryl dimethicone crosspolymer 1 0.7 to 2% Final report 09/12
available from CIRPEG-15/lauryl polydimethylsiloxyethyl dimethiconecrosspolymer
1 not in current use* Final report 09/12available from CIR
PEG-150 1 0.0009 to 6% Final report 06/10available from CIR
PEG-150 Dilaurate 1 up to 25% IJT 19(S2):29-41,2000
PEG-150 Distearate 1 up to 5% IJT 19(S1):51-59,1999
PEG-150 Lanolin 1 not in current use* Final amended report09/12 available from
CIRPEG-150 Laurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-150 Pentaerythrityl Tetrastearate 1 Final report 06/2014
available from CIRPEG-150 Stearate 1 up to 6% IJT 24(S1):1-102,
2005PEG-15 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-15 hydrogenated castor oil isostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-15 hydrogenated castor oil triisostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-15 Hydrogenated Lanolin 1 not in current use* Final amended report09/12 available from
CIRPEG-15 Jojoba Alcohol 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2):169-244
(2012)PEG-16 1 not in current use* Final report 06/10
available from CIRPEG-160M 1 not in current use* Final report 06/10
available from CIRPEG-160 Sorbitan Triisostearate 1 0.5 to 10% IJT 19(S2):43-89,
2000PEG-16 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-16 Cetyl/Oleyl/Stearyl/Lanolin Alcohol Ether 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2):169-244
(2012)PEG-16 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-16 Macadamia Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-16 Soy Sterol 1 up to 0.5% IJT 23(S2):23- 47,
2004PEG-175 Distearate 1 not in current use* IJT 19(S1):51-59,
1999PEG-17 Dimethicone 1 JACT 1(4):33-54,
1982 confirmed02/03 IJT
24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG-18 1 not in current use* Final report 06/10
available from CIRPEG-180 1 0.05 to 5% Final report 06/10
available from CIRPEG-180M 1 0.05 to 0.08% Final report 06/10
available from CIRPEG-18 castor oil dioleate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-18 Palm Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-18 Sorbitan Trioleate 1 not in use at the time* IJT 19(S2):43-89,
2000PEG-192 Apricot Kernel Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-20 1 0.02 to 27% Final report 06/10
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-200 1 not in current use* Final report 06/10available from CIR
PEG-200 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-200 hydrogenated castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-200 Laurate 1 up to 25% IJT 19(S2):29-41,2000
PEG-20 Almond Glycerides 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-20 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-20 Cocamine 1 IJT 18(S1):11-31,1999
PEG-20 Corn Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-20 Dilaurate 1 up to 25% IJT 19(S2):29-41,2000
PEG-20 Distearate 1 up to 5% IJT 19(S1):51-59,1999
PEG-20 Evening Primrose Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-20 hydrogenated castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-20 hydrogenated castor oil isostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-20 hydrogenated castor oil laurate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-20 hydrogenated castor oil pca isostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-20 hydrogenated castor oil triisostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-20 Hydrogenated Lanolin 1 1.0 to 5.0% Final amended report09/12 available from
CIRPEG-20 Hydrogenated Palm Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-20 Lanolin 1 not in current use* Final amended report
09/12 available fromCIR
PEG-20 Laurate 1 up to 25% IJT 19(S2):29-41,2000
PEG-20M 1 0.4 to 3% Final report 06/10available from CIR
PEG-20 methyl glucose distearate 1 Final report 09/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-20 methyl glucose sesquicaprylate/sesquicaprate 1 Final report 09/2013available from CIR
PEG-20 methyl glucose sesquilaurate 1 Final report 09/2013available from CIR
PEG-20 methyl glucose sesquistearate 1 Final report 09/2013available from CIR
PEG-20 Sorbitan Beeswax 1 up to 11% safe for use in the presentpractices of use, except
that cosmetic fornulationscontaining PEG-6, -20,and -75 should not be
used on damaged skin10
IJT 20(S4):27-38,2001
PEG-20 Sorbitan Cocoate 1 not in use at the time* IJT 19(S2):43-89,2000
PEG-20 Sorbitan Isostearate 1 1 to 10% IJT 19 (S2):43-89,2000
PEG-20 Sorbitan Tetraoleate 1 not in use at the time* IJT 19(S2):43-89,2000
PEG-20 Sorbitan Triisostearate 1 not in use at the time* IJT 19(S2):43-89,2000
PEG-20 Stearate 1 up to 4% JACT 2(7):17-60,1983 confirmed
11/02 IJT24(S1):74-80, 2005
PEG-20 Tsubakiate Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-220 1 0.3 to 0.4% Final report 06/10available from CIR
PEG-23M 1 0.05% Final report 06/10available from CIR
PEG-240 1 4 to 10% Final report 06/10available from CIR
PEG-24 Hydrogenated Lanolin 1 0.2 to 0.3% Final amended report09/12 available from
CIRPEG-24 Lanolin 1 not in current use* Final amended report
09/12 available fromCIR
PEG-25 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-25 hydrogenated castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-25 Lanolin 1 not in current use* Final amended report09/12 available from
CIRPEG-25M 1 not in current use* Final report 06/10
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-25 Moringa Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-25 Propylene Glycol Stearate 1 1 to 5% IJT 20(S4):13-26,2001
PEG-25 Soy Sterol 1 up to 2% IJT 23(S2):23-47,2004
PEG-26 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-26 Jojoba Alcohol 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
PEG-27 Lanolin 1 not in current use* Final amended report09/12 available from
CIRPEG-29 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-2 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-2 Cocamine 1 IJT 18(S1):11-31,
1999PEG-2 Diisononanoate 1 2% IJT 30(S3):228-269,
2011PEG-2 Dilaurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-2 Distearate 1 up to 5% IJT 19(S1):51-59,
1999PEG-2 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-2 Laurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-2 Laurate SE 1 up to 25% IJT 19(S2):29-41,
2000PEG-2M 1 0.5% Final report 06/10
available from CIRPEG-2 Olive Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-2 Sorbitan Isostearate 1 not in use at the time* IJT 19(S2):43-89,
2000PEG-2 Stearate 1 up to 2% JACT 2(7):17-60,
1983 confirmed11/02 IJT
24(S1):74-80, 2005PEG-2 Sunflower Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-30 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 16(S3):269-306,
1997; IJT33(S4):13-39, 2014
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-30 Glyceryl Cocoate 1 safe when formulatedto be non- irritating
IJT 19(S1):51-59,1999; Final report12/2014 available
from CIRPEG-30 Hydrogenated Castor Oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 16(S3):269-306,
1997; IJT33(S4):13-39, 2014
PEG-30 Hydrogenated Castor Oil Isostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-30 Hydrogenated Castor Oil Laurate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-30 Hydrogenated Castor Oil PCA Isostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-30 Hydrogenated Castor Oil Triisostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-30 Hydrogenated Lanolin 1 not in current use* IJT 18(S1):61-68,1999; Final amended
report 09/12 availablefrom CIR
PEG-30 Lanolin 1 0.50% JACT 1(4):91-102,1982; Final amended
report 09/12 availablefrom CIR
PEG-30 Sorbitan Tetraoleate 1 not in use at the time* IJT 19(S2):43-89,2000
PEG-30 Sorbitol Tetraoleate Laurate (aka SorbethTetraoleate Laurate)
0 concentration not reported* IJT 19(S2):43-89,2000
PEG-30 Soy Sterol 1 not in current use* IJT 23(S2):23-47,2004
PEG-32 1 0.03 to 15% Final report 06/10available from CIR
PEG-32 Dilaurate 1 up to 25% IJT 19(S2):29-41,2000
PEG-32 Distearate 1 up to 5% IJT 19(S1):51-59,1999
PEG-32 Laurate 1 up to 25% IJT 19(S2):29-41,2000
PEG-32 Methyl Ether Dimethicone 1 Final report 12/2014available from CIR
PEG-32 Stearate 1 up to 6% IJT 24(S1):1-102,2005
PEG-33 1 not in current use* Final report 06/10available from CIR
PEG-33 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-350 1 1% Final report 06/10available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-35 Almond Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-35 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-35 hydrogenated castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-35 Lanolin 1 not in current use* Final amended report09/12 available from
CIRPEG-35 Soy Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-36 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-3 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-3 Cocamine 1 IJT 18(S1):11-31,
1999PEG-3 Dimethicone 1 JACT 1 (4):33-54,
1982 confirmed02/03 IJT
24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG-3 Distearate 1 up to 5% IJT 19(S1):51-59,
1999PEG-3 Glyceryl Cocoate 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-3 Methyl Ether 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2):169-244
(2012)PEG-3 Sorbitan Oleate 1 not in use at the time* IJT 19(S2):43-89,
2000PEG-3 Sorbitan Stearate 1 not in use at the time* IJT 19(S2):43-89,
2000PEG-4 1 0.01 to 67% Final report 06/10
available from CIRPEG-40 1 0.001 to 6% Final report 06/10
available from CIRPEG-400 1 1 to 3% Final report 06/10
available from CIRPEG-40 and -50 Sorbitol Hexaoleate (aka Sorbeth-40 and -50Hexaoleate)
0 concentration not reported* IJT 19(S2):43-89,2000
PEG-40 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-40 Glyceryl Cocoate 1 safe when formulatedto be non- irritating
IJT 19(S1):51-59,1999; Final report12/2014 available
from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-40 Hydrogenated Castor Oil 1 safe for use in cosmeticswhen formulated tobe none-irritating
IJT 16(S3):269-306,1997; IJT
33(S4):13-39, 2014PEG-40 hydrogenated castor oil isostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-40 hydrogenated castor oil laurate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-40 hydrogenated castor oil pca isostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-40 hydrogenated castor oil triisostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-40 Hydrogenated Lanolin 1 not in current use* Final amended report
09/12 available fromCIR
PEG-40 Jojoba Alcohol 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
PEG-40 Lanolin 1 0.25% Final amended report09/12 available from
CIRPEG-40 Olive Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-40 Sorbitan Diisostearate 1 not in use at the time* IJT 19(S2):43-89,
2000PEG-40 Sorbitan Lanolate 1 0.1 to 1% IJT 19 (S2):43-89,
2000PEG-40 Sorbitan Laurate 1 not in use at the time* IJT 19(S2):43-89,
2000PEG-40 Sorbitan Perisostearate 1 not in use at the time* IJT 19(S2):43-89,
2000PEG-40 Sorbitan Peroleate 1 up to 25% IJT 19 (S2):43-89,
2000PEG-40 Sorbitan Stearate 1 not in use at the time* IJT 19(S2):43-89,
2000PEG-40 Sorbitan Tetraoleate and 1 0.5 to 10% IJT 19(S2):43-89,
2000PEG-40 Soy Sterol 1 not in current use* IJT 23 (S2):23-47,
2004PEG-40 Stearate 1 up to 7% JACT 2(7):17-60,
1983 confirmed11/02 IJT
24(S1):74-80, 2005PEG-42 Babassu Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-42 Mushroom Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-44 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-44 Sorbitan Laurate 1 1 to 5% IJT 19 (S2):43-89,2000
PEG-45 1 not in current use* Final report 06/10available from CIR
PEG-450 1 1% Final report 06/10available from CIR
PEG-45 hydrogenated castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-45M 1 0.03 to 0.3% Final report 06/10available from CIR
PEG-45 Palm Kernel Glycerides 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-45 Safflower Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-4 Caprylic/capric Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-4 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-4 Dilaurate 1 up to 25% IJT 19(S2):29-41,2000
PEG-4 Dimethacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
PEG-4 Distearate 1 up to 5% IJT 19(S1):51-59,1999
PEG-4 Distearyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
PEG-4 Ditallow Ether 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
PEG-4 Laurate 1 up to 25% IJT 19(S2):29-41,2000
PEG-4 Methyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
PEG-4 PEG-12 Dimethicone* 1 Final report 12/2014available from CIR
PEG-4-PPG-7 C13/C15 Alcohol 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG-500 1 not in current use* Final report 06/10available from CIR
PEG-50 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-50 Distearate 1 up to 5% IJT 19(S1):51-59,1999
PEG-50 hydrogenated castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-50 hydrogenated castor oil isostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-50 hydrogenated castor oil laurate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-50 hydrogenated castor oil succinate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-50 hydrogenated castor oil triisostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-50 Lanolin 1 concentration not reported* Final amended report09/12 available from
CIRPEG-50 Stearate 1 up to 9% JACT 2(7):17-60,
1983 confirmed11/02 IJT
24(S1):74-80, 2005PEG-54 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-54 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-55 1 not in current use* Final report 06/10
available from CIRPEG-55 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-55 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-55 Lanolin 1 not in current use* Final amended report
09/12 available fromCIR
PEG-55 Propylene Glycol Oleate 1 up to 10% IJT 20(S4):13-26,2001
PEG-58 hydrogenated castor oil isostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-5 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-5 hydrogenated castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
Final amended report09/12 available from
CIRPEG-5 hydrogenated castor oil isostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-5 hydrogenated castor oil triisostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-5 Hydrogenated Corn Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-5 Hydrogenated Lanolin 1 not in current use* Final amended report09/12 available from
CIRPEG-5 Isononanoate 1 1% Final report 06/10
available from CIRPEG-5 Lanolin 1 concentration not reported* Final amended report
09/12 available fromCIR
PEG-5M 1 0.01% Final report 06/10available from CIR
PEG-5 Sorbitan Isostearate 1 not in use at the time* IJT 19(S2):43-89,2000
PEG-5 Soy Sterol 1 up to 2% IJT 23(S2):23-47,2004
PEG-5 Tsubakiate Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-6 1 0.01 to 51% Final report 06/10available from CIR
PEG-60 1 not in current use* Final report 06/10available from CIR
PEG-60 Almond Glycerides 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-60 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-60 castor oil isostearate 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-60 castor oil isostearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final amended report09/12 available from
CIRPEG-60 Corn Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-60 Evening Primrose Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-60 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-60 hydrogenated castor oil laurate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-60 hydrogenated castor oil pca isostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-60 Hydrogenated Castor Oil Triisostearate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-60 Lanolin 1 0.4 to 2% Final amended report
09/12 available fromCIR
PEG-60 Passiflora Edulis Seed Glycerides* 1 safe when formulatedto be non-irritating
Final report 12/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-60 Passiflora Incarnata Seed Glycerides* 1 safe when formulatedto be non-irritating
Final report 12/2014available from CIR
PEG-60 Shea Butter Glycerides 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-60 Sorbitan Stearate 1 not in use at the time* IJT 19(S2):43-89,2000
PEG-60 Sorbitan Tetraoleate 1 0.5 to 10% IJT 19(S2):43-89,2000
PEG-60 Sorbitan Tetrastearate 1 not in use at the time* IJT 19(S2):43-89,2000
PEG-60 Sorbitol Tetrastearate (aka Sorbeth Tetrastearate) 0 concentration not reported* IJT 19(S2):43-89,2000
PEG-60 Tsubakiate Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-65 hydrogenated castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-65M 1 not in current use* Final report 06/10available from CIR
PEG-6 Almond Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-6 Caprylic/capric Glycerides 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-6 Dilaurate 1 up to 25% IJT 19(S2):29-41,2000
PEG-6 Dimethicone* 1 Final report 12/2014available from CIR
PEG-6 Distearate 1 up to 5% IJT 19(S1):51-59,1999
PEG-6 hydrogenated castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
Final amended report09/12 available from
CIRPEG-6 Hydrogenated Palm/palm Kernel Glyceride* 1 safe when formulated
to be non-irritatingIJT 33(S4):13-39,
2014PEG-6 Laurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-6 Methyl Ether 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2):169-244
(2012)PEG-6 Methyl Ether Dimethicone 1 Final report 12/2014
available from CIRPEG-6 Olive Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-6 Sorbitan Beeswax 1 not in current use* safe for use in the present
practices of use, exceptthat cosmetic fornulations
containing PEG-6, -20,and -75 should not be
used on damaged skin10
IJT 20 (S4):27-38,2001
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-6 Sorbitan Oleate 1 not in use at the time* IJT 19(S2):43-89,2000
PEG-6 Sorbitan Stearate 1 not in use at the time* IJT 19(S2):43-89,2000
PEG-6 Stearate 1 up to 6% IJT 24(S1):1-102,2005
PEG-7 1 not in current use* Final report 06/10available from CIR
PEG-7/PPG-2 Propylheptyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
PEG-70 Hydrogenated Lanolin 1 not in current use* Final amended report09/12 available from
CIRPEG-70 Lanolin 1 not in current use* Final amended report
09/12 available fromCIR
PEG-70 Lanolin 1 Final amended report09/12 available from
CIRPEG-70 Mango Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-75 1 0.2 to 36% Final report 06/10
available from CIRPEG-75 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-75 Cocoa Butter Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-75 crambe abyssinica seed oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-75 Dilaurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-75 Distearate 1 not in current use* IJT 19 (S1):51-59,
1999PEG-75 Lanolin 1 0.001 to 15% Final amended report
09/12 available fromCIR
PEG-75 Lanolin 1 Final amended report09/12 available from
CIRPEG-75 Lanolin Oil 1 concentration not reported* Final amended report
09/12 available fromCIR
PEG-75 Lanolin Wax 1 not in current use* Final amended report09/12 available from
CIRPEG-75 Laurate 1 up to 25% IJT 19(S2):29-41,
2000
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-75 meadowfoam oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-75 Propylene Glycol Stearate 1 not in current use* IJT 20(S4):13-26,2001
PEG-75 Shea Butter Glycerides 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-75 Shorea Butter Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-75 Sorbitan Lanolate 1 up to 10% IJT 19 (S2):43-89,2000
PEG-75 Sorbitan Laurate 1 1 to 5% IJT 19 (S2):43-89,2000
PEG-75 Soy Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-78 Glyceryl Cocoate* 1 safe when formulatedto be non- irritating
IJT 19(S1):51-59,1999; Final report12/2014 available
from CIRPEG-7 Caprylic/capric Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-7 Cocoglycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-7 Dimethicone 1 JACT 1(4):33-54,
1982 confirmed02/03 IJT
24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG-7 Glyceryl Cocoate 1 safe when formulated
to be non- irritatingIJT 19(S1):51-59,1999; Final report12/2014 available
from CIRPEG-7 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-7M 1 0.05 to 0.5% Final report 06/10
available from CIRPEG-7 Methyl Ether 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2):169-244
(2012)PEG-7 Methyl Ether Dimethicone* 1 Final report 12/2014
available from CIRPEG-7 Olive Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-7 Propylheptyl Ether 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2):169-244
(2012)PEG-7 Sunflower Glycerides* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-8 1 0.0002 to 85% Final report 06/10
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-80 1 not in current use* Final report 06/10available from CIR
PEG-800 1 not in current use* Final report 06/10available from CIR
PEG-80 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-80 Glyceryl Cocoate 1 safe when formulatedto be non- irritating
IJT 19(S1):51-59,1999; Final report12/2014 available
from CIRPEG-80 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-80 methyl glucose laurate 1 not in current use* Final report 09/2013
available from CIRPEG-80 Sorbitan Laurate 1 concentration not reported* IJT 19(S2):43-89,
2000PEG-80 Sorbitan Palmitate 1 not in use at the time* IJT 19(S2):43-89,
2000PEG-85 Lanolin 1 concentration not reported* Final amended report
09/12 available fromCIR
PEG-85 Lanolin 1 Final amended report09/12 available from
CIRPEG-8 Caprylic/capric Glycerides 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPEG-8 castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014PEG-8 Cetyl Dimethicone 1 Final report 12/2014
available from CIRPEG-8 Dilaurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-8 Dimethicone 1 JACT 1(4):33-54,
1982 confirmed02/03 IJT
24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG-8 Dimethicone/dimer Dilinoleic Acid Copolymer 1 Final report 12/2014
available from CIRPEG-8 dimethicone/polysorbate 20 crosspolymer 1 not in current use* IJT 33 (S2): 65-115,
2014PEG-8 Dimethicone Dimer Dilinoleate* 1 Final report 12/2014
available from CIRPEG-8 Distearate 1 up to 5% IJT 19(S1):51-59,
1999PEG-8 hydrogenated castor oil 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-8 Hydrogenated Fish Glycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-8 Laurate 1 up to 25% IJT 19(S2):29-41,2000
PEG-8 Methicone 1 Final report 12/2014available from CIR
PEG-8 Methyl Ether Dimethicone* 1 Final report 12/2014available from CIR
PEG-8 PEG-4 Dimethicone* 1 Final report 12/2014available from CIR
PEG-8 PPG-8 Dimethicone* 1 Final report 12/2014available from CIR
PEG-8 Propylene Glycol Cocoate 1 1 to 5% IJT 20(S4):13-26,2001
PEG-8 Propylheptyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
PEG-8 Sorbitan Beeswax 1 not in current use* safe for use in the presentpractices of use, except
that cosmetic fornulationscontaining PEG-6, -20,and -75 should not be
used on damaged skin11
IJT 20(S4):27-38,2001
PEG-8 Stearate 1 up to 3% JACT 2(7):17-60,1983 confirmed
11/02 IJT24(S1):74-80, 2005
PEG-9 1 0.02 to 0.9% Final report 06/10available from CIR
PEG-90 1 0.05 to 21% Final report 06/10available from CIR
PEG-90M 1 0.0002 to 0.3% Final report 06/10available from CIR
PEG-9 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
PEG-9 Cocoglycerides* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
PEG-9 Dimethicone 1 JACT 1(4):33-54,1982 confirmed
02/03 IJT24(S1):42-44, 2005;Final report 12/2014
available from CIRPEG-9 Distearate 1 not in current use* IJT 19 (S1):51-59,
1999PEG-9 Laurate 1 up to 25% IJT 19(S2):29-41,
2000PEG-9M 1 not in current use* Final report 06/10
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PEG-9 Methyl Ether Dimethicone* 1 Final report 12/2014available from CIR
PEG-9 Polydimethylsiloxyethyl Dimethicone 1 Final report 12/2014available from CIR
PEG-Cetyl Stearyl Diether 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Pelargonic Acid 1 not in use at the time* IJT 30(S3):228-269,2011
Pentaerythrityl Cocoate (amended) 1 concentration not reported* IJT 30(S1):5S-16SPentaerythrityl Rosinate 1 JACT 13(5):395-399,
1994; IJT17(S4):83-94, 1998
Pentaerythrityl Tetrabehenate 1 2 to 3% Final report 12/11available from CIR
Pentaerythrityl Tetrabehenate/Benzoate/Ethylhexanoate 1 0.5 to 16% Final report 12/11available from CIR
Pentaerythrityl Tetrabenzoate 1 not in use at the time* Final report 12/11available from CIR
Pentaerythrityl Tetra C5-10 Acid Esters 1 not in use at the time* Final report 12/11available from CIR
Pentaerythrityl Tetra C5-9 Acid Esters 1 not in use at the time* Final report 12/11available from CIR
Pentaerythrityl Tetracaprylate/Tetracaprate 1 0.07 to 5% Final report 12/11available from CIR
Pentaerythrityl Tetracocoate 1 not in use at the time* Final report 12/11available from CIR
Pentaerythrityl Tetra-Di-t-Butyl Hydroxyhydrocinnamate 1 0.00001- 0.8% Final report 03/2014available from CIR
Pentaerythrityl Tetraethylhexanoate 1 0.06 to 50% Final report 12/11available from CIR
Pentaerythrityl Tetraethylhexanoate/Benzoate 1 40% Final report 12/11available from CIR
Pentaerythrityl Tetraisononanoate 1 not in use at the time* Final report 12/11available from CIR
Pentaerythrityl Tetraisostearate 1 0.1 to 55% Final report 12/11available from CIR
Pentaerythrityl Tetramyristate 1 not in use at the time* Final report 12/11available from CIR
Pentaerythrityl Tetraoleate 1 not in use at the time* Final report 12/11available from CIR
Pentaerythrityl Tetrapelargonate 1 2% Final report 12/11available from CIR
Pentaerythrityl Tetrastearate 1 7% Final report 12/11available from CIR
Pentasodium Pentetate 1 up to 3% IJT 27 (S2): 71-92,2008
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Pentetic Acid 1 up to 0.03% IJT 27 (S2): 71-92,2008
Pentylene Glycol 1 0.001 to 5% IJT 31 (S2): 147-168,2012
Perfluorononyl dimethicone/methicone/amodimethiconecrosspolymer
1 0.70% IJT 33 (S2): 65-115,2014
Perilla Ocymoides Seed Oil 1 concentration not reported* Final report 03/11available from CIR
Persea Gratissima (Avocado) Butter 1 concentration not reported* Final report 03/11Available from CIR
Persea Gratissima (Avocado) Oil 1 0.0001 to 98% Final amended report03/11 available
from CIR; JEPT4(4):93-103, 1980
(original) re-reviewIJT 22(S1):1-35,
2003Persea Gratissima (Avocado) Oil Unsaponifiables 1 0.2 to 6% Final report 03/11
available from CIRPersea Gratissima (Avocado) Sterols 1 Final report 12/2013
available from CIRPetroleum Distillates (aka Petroleum Distillate) 1 up to 82% JACT 5(3):225-248,
1986 confirmed12/06
Phenethyl Alcohol 1 up to 1% JACT 9(2):165-83,1990 confirmed
08/06Phenoxyethanol 1 less than or equal
to 0.0002 to 1%JACT 9(2):259-77,
1990Phenylalanine 1 0.00009 to 0.03% IJT 32(S4):41-64,
2013Phenyl Methyl Pyrazolone 1 up to 1% JACT 11 (4):475-88,
1992Phenyl Trimethicone 1 up to 36% JACT 5(5):353-
71, 1986 confirmed06/04 IJT 25(S2),
2006Phloroglucinol 1 JACT 14(6):468-75,
1995P-hydroxyanisole 1 1 safe for use in nail adhesives
and in artificial nail coatings,as a polymerization inhibitor,that are cured by LED light;
unsafe for use in all othercosmetics due to dermaldepigmentation potential
JACT 4 (5):31-63,1985 confirmed
09/03 IJT 25(S2),2006; Final report12/2014 available
from CIRPhytantriol 1 up to 3% IJT 26(S1):107- 114,
2007
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Phytosterols 1 Final report 12/2013available from CIR
Phytosteryl butyrate 1 not in current use* Final report 12/2013available from CIR
Phytosteryl canolate 1 Final report 12/2013available from CIR
Phytosteryl caprylate/caprate 1 not in current use* Final report 12/2013available from CIR
Phytosteryl hydroxystearate 1 not in current use* Final report 12/2013available from CIR
Phytosteryl isostearate 1 Final report 12/2013available from CIR
Phytosteryl linoleate 1 not in current use* Final report 12/2013available from CIR
Phytosteryl linoleate\linoleate 1 not in current use* Final report 12/2013available from CIR
Phytosteryl Macadamiate 1 Final report 12/2013available from CIR
Phytosteryl Nonanoate 1 not in use at the time* IJT 30(S3):228-269,2011; Final report12/2013 available
from CIRPhytosteryl Oleate 1 Final report 12/2013
available from CIRPhytosteryl Rice Branate 1 Final report 12/2013
available from CIRPhytosteryl Ricinoleate 1 not in current use* Final report 12/2013
available from CIRPhytosteryl sunflowerseedate 1 not in current use* Final report 12/2013
available from CIRPicramic Acid 1 up to 0.6% IJT 28(S3): 205-216,
2009Piper Methysticum Leaf/Root/Stem Extract 1 IJT 28(S2): 175-188,
2009Piper Methysticum Root Extract 1 IJT 28(S2): 175-188,
2009Pistacia Vera Seed Oil 1 0.003 to 1% Final report 03/11
available from CIRPlacental Enzymes 1 if used, should not deliver
any metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Placental Lipids 1 if used, should not deliverany metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Placental Proteins 1 if used, should not deliverany metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Plamitamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Plukenetia Volubilis Seed Oil 1 0.05 to 0.6% Final report 03/11available from CIR
p-Methylaminophenol 1 up to 0.7% Final AmendedReport 12/07
Available from CIRJACT 10(1):53-65,
1991 (original report)p-Methylaminophenol Sulfate (amended) 1 up to 0.7% Final Amended
Report 12/07Available from CIRJACT 10(1):53-65,
1991 (original report)Poloxamer 101 1 not in current use* IJT 27 (S2): 93-128,
2008Poloxamer 105 1 up to 3% IJT 27 (S2): 93-128,
2008Poloxamer 105 Benzoate 1 not in current use* IJT 27 (S2): 93-128,
2008Poloxamer 108 1 not in current use* IJT 27 (S2): 93-128,
2008Poloxamer 122 1 not in current use* IJT 27 (S2): 93-128,
2008Poloxamer 123 1 not in current use* IJT 27 (S2): 93-128,
2008Poloxamer 124 1 not in current use* IJT 27 (S2): 93-128,
2008Poloxamer 181 1 up to 6% IJT 27 (S2): 93-128,
2008Poloxamer 182 1 up to 6% IJT 27 (S2): 93-128,
2008Poloxamer 182 Benzoate 1 not in current use* IJT 27 (S2): 93-128,
2008Poloxamer 183 1 not in current use* IJT 27 (S2): 93-128,
2008
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Poloxamer 184 1 up to 10% IJT 27 (S2): 93-128,2008
Poloxamer 185 1 up to 9% IJT 27 (S2): 93-128,2008
Poloxamer 188 1 up to 2% IJT 27 (S2): 93-128,2008
Poloxamer 212 1 up to 2% IJT 27 (S2): 93-128,2008
Poloxamer 215 1 not in current use* IJT 27 (S2): 93-128,2008
Poloxamer 217 1 concentration not reported* IJT 27 (S2): 93-128,2008
Poloxamer 231 1 not in current use* IJT 27 (S2): 93-128,2008
Poloxamer 234 1 up to 10% IJT 27 (S2): 93-128,2008
Poloxamer 235 1 not in current use* IJT 27 (S2): 93-128,2008
Poloxamer 237 1 concentration not reported* IJT 27 (S2): 93-128,2008
Poloxamer 238 1 concentration not reported* IJT 27 (S2): 93-128,2008
Poloxamer 282 1 not in current use* IJT 27 (S2): 93-128,2008
Poloxamer 284 1 not in current use* IJT 27 (S2): 93-128,2008
Poloxamer 288 1 not in current use* IJT 27 (S2): 93-128,2008
Poloxamer 331 1 not in current use* IJT 27 (S2): 93-128,2008
Poloxamer 333 1 1% IJT 27 (S2): 93-128,2008
Poloxamer 334 1 0.3% IJT 27 (S2): 93-128,2008
Poloxamer 335 1 concentration not reported* IJT 27 (S2): 93-128,2008
Poloxamer 338 1 concentration not reported* IJT 27 (S2): 93-128,2008
Poloxamer 401 1 concentration not reported* IJT 27 (S2): 93-128,2008
Poloxamer 402 1 not in current use* IJT 27 (S2): 93-128,2008
Poloxamer 403 1 not in current use* IJT 27 (S2): 93-128,2008
Poloxamer 407 1 up to 20% IJT 27 (S2): 93-128,2008
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Polstyrene/hydrogenated polyisopentene copolymer 1 Final report 09/2014available from CIR
Polyacrylamide (Amended) 1 safe if the level of acrylamidemonomer in formulationis not greater than 5ppm
IJT 24(S2):21-50,2005 JACT
10(1):193-203, 1991(Original Report)
Polyacrylate-12 1 not in current use* Final report 09/2014available from CIR
Polyacrylate-15 1 Final report 09/2014available from CIR
Polyacrylate-16 1 Final report 09/2014available from CIR
Polyacrylate-18 1 not in current use* Final report 09/2014available from CIR
Polyacrylate-2 1 not in current use* Final report 09/2014available from CIR
Polyacrylate-21 1 Final report 09/2014available from CIR
Polyacrylate-30 1 not in current use* Final report 09/2014available from CIR
Polyacrylate-5 1 Final report 09/2014available from CIR
Polyacrylic Acid 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Polyamino Sugar Condensate 1 up to 1% JACT 1 (4):25-32,1982 confirmed
02/02 IJT24(S1):80-81, 2005
Polybutene 1 up to 92% JACT 1(4):103-18,1982 confirmed
06/02 IJT24(S1):81-82, 2005
Polybutylene terephthalate 1 IJT 33(S3):36-47,2014
Polydimethylsiloxyethyl dimethicone/bis-vinyldimethiconecrosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Polyethylene 1 0.09 to 24% IJT 26(S1):115-127,2007
Polyethylene isoterephthalate 1 IJT 33(S3):36-47,2014
Polyethylene terephthalate 1 IJT 33(S3):36-47,2014
Polyglyceryl-20 Octaisononanoate 1 3% Final report 12/11available from CIR
Polyglyceryl-2 Lanolin Alcohol Ether 1 not in current use* Final amended report09/12 available from
CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Polyglyceryl-3/lauryl polydimethylsiloxyethyl dimethiconecrosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Polyisobutene 1 up to 76% IJT 27(S4): 83-106,2008
Polymethyl Methacrylate (PMMA) 1 up to 30% IJT 30 (1): 54-65,2011
Polyoxymethylene Melamine (formerly Melamine/Formaldehyde Resin)
1 JACT 14(5):373-85,1995
Polyoxymethylene Urea 1 concentration of freeformaldehyde should be0.2%; unsafe for aerosols
JACT 14(3):204-20,1995 confirmed
12/09Polypentaerythrityl terephthalate 1 not in current use* IJT 33(S3):36-47,
2014Polypropylene Glycols (PPG) 1 50% JACT 13 (6):437-91,
1994 reopened 12/09tentative amended
report 04/10 availablefrom CIR
Polypropylene Terephthalate 1 IJT 33(S3):36-47,2014
Polyquaternium-10 1 up to 5% JACT 7(3): 335-51,1988 confirmed
09/05Polyquaternium-11 1 up to 10% JACT 2(5):161-78,
1983 confirmed11/02 IJT
24(S1):82-83, 2005Polyquaternium-14 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Polyquaternium-22 1 Final report 09/2013
Available from CIRPolyquaternium-28 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Polyquaternium-32 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Polyquaternium-33 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Polyquaternium-35 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Polyquaternium-36 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Polyquaternium-37 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Polyquaternium-39 1 Final report 09/2013
Available from CIRPolyquaternium-45 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Polyquaternium-47 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Polyquaternium-48 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Polyquaternium-53 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Polyquaternium-63 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Polyquaternium-7 1 up to 0.4% JACT 14(6):476-84, 1995; confirmed
04/2010Polyquaternium-73 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Polyquaternium-91 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Polysilicone-13 1 Final report 12/2014
available from CIRPolysorbate-20 1 > 50% JACT 3(5):1-82,
1984Polysorbate-21 1 up to 1% JACT 3(5):1-82,
1984Polysorbate-40 1 up to 10% JACT 3(5):1-82,
1984Polysorbate-60 1 up to 25% JACT 3(5):1-82,
1984Polysorbate-61 1 up to 5% JACT 3(5):1-82,
1984Polysorbate-65 1 up to 5% JACT 3(5):1-82,
1984Polysorbate-80 1 up to 25% JACT 3(5):1-82,
1984Polysorbate-81 1 up to 5% JACT 3(5):1-82,
1984Polysorbate-85 1 > 50% JACT 3(5):1-82,
1984Polystyrene 1 Final report 09/2014
available from CIRPolyvinyl Acetate (Amended) 1 <25% of a 55 to
60% emulsionJACT 15(2):166-76,
1996 JACT11(4):465-73, 1992
(Original Report)Polyvinyl Alcohol 1 up to 10% IJT 17(S5):67-94,
1998Potassium Acetate 1 3% IJT 31(S1):112-136,
2012
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Potassium Acrylates/C10-30 Alkyl Acrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Potassium Aluminum Polyacrylate 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Potassium Ascorbyl Tocopheryl Phosphate 1 <= 0.02% IJT 21(S3):51-116,2002; Final report03/2014 available
from CIRPotassium Aspartate 1 0.003 to 0.008% IJT 32(S4):41-64,
2013Potassium Babassuate 1 not in use at the time* Final report 03/11
available from CIRPotassium Benzoate 1 0.0002 to 0.0003% Final report 10/11
available from CIRPotassium Bromate 1 10.17% (calculated
as Sodium Bromate)JACT 13(5):400-14,
1994Potassium Butyl Ester of PVM/MA Copolymer (Amended) 1 not in current use* Amended Final
Report 06/09Available from CIRJACT 12(3):243-56,
1993 (original report)Potassium C11-15 alkyl phosphate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIRPotassium C12-13 alkyl phosphate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIRPotassium C12-14 alkyl phosphate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIRPotassium C9-15 alkyl phosphate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIRPotassium Caproyl Tyrosine 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRPotassium capryloyl glutamate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRPotassium Cellulose Succinate 1 not in use at the time* Amended Safety
Assessment 03/09available from CIR
Potassium Cetyl Phosphate 1 safe for use when formulatedto be non- irritating
Final report 09/2014available from CIR
Potassium Chlorate 1 JACT 14(3):221-30,1995
Potassium citrate 1 0.002 to 0.6% IJT 33 (S2): 16-46,2014
Potassium Cocoate (amended) 1 0.003 to 40% IJT 30(S1):5S-16SPotassium cocoyl glutamate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Potassium cocoyl glycinate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium Cocoyl Hydrolyzed Collagen (formerlyPotassium-Coco-Hydrolyzed Animal Protein)
1 up to 20% JACT 2(7):75-86,1983 confirmed
11/02 IJT 24(S1):82-85, 2005
Potassium cocoyl rice amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium Cornate 1 not in current use* IJT 30 (S1):17-39,2011; Final report
03/11 available fromCIR
Potassium Cumenesulfonate 1 not in current use* IJT 30(S3):270-283,2011
Potassium Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 29 (S4) 288-305,2010
Potassium Ethyl Ester of PVM/MA Copolymer 1 not in current use* IJT 30 (S2):128-144,2011
Potassium Gluconate 1 Final report 03/2014available from CIR
Potassium Glycolate 1 IJT 17(S1):1-242,1998
Potassium Glycyrrhetinate 1 up to 1% IJT 26 (S2):79-112,2007
Potassium Glycyrrhizinate 1 not in current use* IJT 26(S2):79-112,2007
Potassium Hyaluronate 1 concentration not reported* IJT 28 (1): 5-67,2009
Potassium Hydrogenated Cocoate (amended) 1 not in current use* IJT 30(S1):5S-16SPotassium Hydrogenated Palmate 1 not in current use* Final report 03/11
available from CIRPotassium Lactate 1 IJT 17(S1):1-242,
1998potassium lauroyl collagen amino acids* 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRpotassium lauroyl glutamate* 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRpotassium lauroyl oat amino acids* 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRpotassium lauroyl pea amino acids* 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRpotassium lauroyl silk amino acids* 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRpotassium lauroyl wheat amino acids 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRPotassium Lauryl Phosphate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Potassium Metabisisulfite 1 concentration not reported* IJT 22(S2):63-88,2003
Potassium Myristate 1 up to 7% IJT 29(S3) :162-186,2010
Potassium Myristoyl Glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium Octoxynol-12 Phosphate 1 up to 0.05% IJT 23(S1):59-111,2004
Potassium Olivate 1 concentration not reported* Final report 03/11available from CIR
Potassium olivoyl/lauroyl wheat amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium Palmate 1 0.3 to 3% Final report 03/11available from CIR
Potassium Palm Kernelate 1 0.3 to 30% Final report 03/11available from CIR
Potassium PCA 1 safe as used; shouldnot be used in cosmetic
products in which N-nitrosocompounds can be formed
Final report 12/2014available from CIR
Potassium Peanutate 1 not in current use* Final report 03/11available from CIR
potassium PEG-50 hydrogenated castor oil succinate* 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Potassium Persulfate 1 safe as oxidizing agentsin hair colorants and
lighteners designed forbrief, discontinuous usefollowed by thorough
rinsing from hair and skin
IJT 20(S3):7-21,2001
Potassium Polyacrylate 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Potassium Rapeseedate 1 not in current use* Final report 03/11available from CIR
Potassium Ricinoleate 1 not in current use* IJT 26(S3) 2007Potassium Safflowerate 1 not in current use* Final report 03/11
available from CIRPotassium Salicylate 1 safe when formulated to
avoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Potassium Silicate 1 not reported* safe for use when formulatedto avoid skin irritation
IJT 24(S1):103-117,2005
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Potassium Sorbate 1 up to 1% JACT 7(6):837-80,1988 confirmed
04/06Potassium Soyate 1 not in current use* Final report 03/11
available from CIRPotassium Stearate 1 up to 12% JACT 1(2):143-
77, 1982 confirmed11/01 IJT
22(S1):1-35, 2003Potassium Stearoyl glutamate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRPotassium Sulfite 1 concentration not reported* IJT 22(S2):63-88,
2003Potassium Tallate 1 concentration not reported* IJT 28(S3):252-258,
2009Potassium Thioglycolate 1 safe for use in hair
straighteners permanentwaves, tonics, dressings, and
so forth, wave sets, othernoncoloring hair products,and hair dyes and colors, atconcentrations up to 15.2%;
hairdressers should avoidskin contact and minimizeconsumer skin exposure;safe for use in depilitories
when formulated to be non-irritating under conditions
of recommended use.
IJT 28(S3):68-133,2009
Potassium Toluenesulfonate 1 not in current use* IJT 30(S3):270-283,2011
Potassium undecylenoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Potassium Xylenesulfonate 1 not in current use* IJT 30(S3):270-283,2011
Potassium Xylenesulfonate 1 not in current use* IJT 30(S3):270-283,2011
PPG >= 3 0 Because PPGs of variouschain lengths are likely to
be added to the InternationalCosmetic Ingredient
Dictionary and Handbook inthe future, the CIR ExpertPanel concluded that anyPPG>=3 would be safe
for use in cosmetics whenformulated to be non-irritating
IJT 31(2) 245-260,2012
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-10-Ceteareth-20 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-10 Lanolin Alcohol Ether 1 not in current use* Final amended report09/12 available from
CIRPPG-10 methyl glucose ether 1 Final report 09/2013
Available from CIRPPG-11 Stearyl Ether 1 2 to 10% IJT 20(S4):53- 59,
2001PPG-12 1 safe when formulated
to be non- irritatingJACT 13(6):437-91,
1994; IJT 31(2)245-260, 2012
PPG-12-Buteth-16 1 up to 31% IJT 19(S1):47-67,2000
PPG-12 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-12 Butyl Ether Dimethicone* 1 Final report 12/2014available from CIR
PPG-12 Dimethicone 1 Final report 12/2014available from CIR
PPG-12-PEG-50 Lanolin 1 0.2 to 8% Final amended report09/12 available from
CIRPPG-12-PEG-65 Lanolin Oil 1 0.002 to 0.04% Final amended report
09/12 available fromCIR
PPG-13 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
PPG-13-Decyltetradeceth-24 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-14 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-14-Deceth-6 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-15 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-15 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-15 Stearyl Ether 1 2 to 10% IJT 20(S4):53- 59,2001
PPG-16 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
PPG-16 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-17 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-17 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-18 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-1-Ceteth-1 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Ceteth-10 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Ceteth-20 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Ceteth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Deceth-4 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Deceth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Deceth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Deceth-7 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Isodeceth-4 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Isodeceth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Isodeceth-7 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1-Isodeceth-9 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1 Trideceth-13 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-1 Trideceth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-20 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-20 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-20-Decyltetradeceth-10 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-20 Lanolin Alcohol Ether 1 not in current use* Final amended report09/12 available from
CIRPPG-20 methyl glucose ether 1 Final report 09/2013
Available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-20 methyl glucose ether acetate 1 not in current use* Final report 09/2013Available from CIR
PPG-20 methyl glucose ether distearate 1 Final report 09/2013Available from CIR
PPG-20-PEG-20 Hydrogenated Lanolin 1 not in current use * Final amended report09/12 available from
CIRPPG-22 Butyl Ether 1 safe when formulated
to be non- irritatingIJT 20(S4):39-52,
2001PPG-23-Steareth-34 1 not in current use* safe when formulated
to be non-irritatingFinal report 09/2013Available from CIR
PPG-24 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-25 Diethylmonium Chloride 1 IJT 18(S3):57- 59,2000
PPG-25 Dimethicone* 1 Final report 12/2014available from CIR
PPG-25-Laureth-25 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-25 methyl glucose ether 1 not in current use* Final report 09/2013Available from CIR
PPG-26 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-26-Buteth-26 1 2.5% IJT 19(S1):47-67,2000
PPG-26 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-27 Dimethicone* 1 Final report 12/2014available from CIR
PPG-28-Buteth-35 1 22% IJT 19(S1):47-67,2000
PPG-2 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-2 C12-13 Pareth-8 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-2 C12-15 Pareth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2 C9-11 Pareth-11 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2 C9-11 Pareth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2 C9-11 Pareth-7 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2 C9-11 Pareth-8 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-2-Ceteareth-9 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-2-Ceteth-1 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Ceteth-10 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-2-Ceteth-20 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Ceteth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-10 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-12 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-15 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-20 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-3 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-30 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-40 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-50 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-60 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-7 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Deceth-8 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2 Dimethicone 1 Final report 12/2014available from CIR
PPG-2-Isodeceth-10 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Isodeceth-12 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Isodeceth-18 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Isodeceth-25 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Isodeceth-4 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-2-Isodeceth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Isodeceth-8 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Isodeceth-9 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2 Lanolin Alcohol Ether 1 not in current use* Final amended report09/12 available from
CIRPPG-2-Laureth-12 1 not in current use* safe when formulated
to be non-irritatingFinal report 09/2013Available from CIR
PPG-2-Laureth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2-Laureth-8 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-2 Methyl Ether 1 up to 2% IJT 28(S2): 162- 174,2009
PPG-2 Methyl Ether Acetate 1 not in current use * IJT 28(S2): 162-174,2009
PPG-2-PEG-11 Hydrogenated Lauryl Alcohol Ether 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-3 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
PPG-30 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-30 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-30 Lanolin Alcohol Ether 1 not in current use* Final amended report09/12 available from
CIRPPG-30 Steareth-4 1 not in current use* safe when formulated
to be non-irritatingFinal report 09/2013Available from CIR
PPG-33 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
PPG-33 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-34 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-34-Steareth-3 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-38 Steareth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-3 C12-14 Sec-Pareth-7 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-3-Isodeceth-1 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-3-Isosteareth-9 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-3-Laureth-10 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-3-Laureth-12 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-3-Laureth-8 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-3-Laureth-9 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-3 Methyl Ether 1 concentration not reported * IJT 28(S2): 162-174,2009
PPG-3-Myreth-11 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-3-Myreth-3 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-3-PEG-6 Oleyl Ether 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-40 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-40 Diethylmonium Chloride 1 IJT 18(S3):57-59,1999
PPG-40-PEG-60 Lanolin Oil 1 not in current use* Final amended report09/12 available from
CIRPPG-4 Butyl Ether 1 safe when formulated
to be non- irritatingIJT 20(S4):39-52,
2001PPG-4 C12-14 Sec-Pareth-5 1 safe when formulated
to be non- irritatingFinal report 09/2013Available from CIR
PPG-4 C13-15 Sec-Pareth-15 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Ceteareth-12 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Ceteth-1 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Ceteth-10 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Ceteth-20 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Ceteth-5 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Deceth-4 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Deceth-6 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-4-Isodeceth-10 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Laureth-15 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Laureth-2 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Laureth-5 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4-Laureth-7 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-4 Oleth-10 Dimethicone* 1 Final report 12/2014available from CIR
PPG-4-Tricedeth-6 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-51 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
PPG-52 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
PPG-52 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-53 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-5 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-5 C12-14 Sec-Pareth-7 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-5 C12-14 Sec-Pareth-9 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-5 C9-15 Pareth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-5-Ceteth-20 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-5 Lanolin Alcohol Ether 1 not in current use* Final amended report09/12 available from
CIRPPG-5 Lanolin Wax 1 2.0 to 4.0% IJT 16(S3):307
-316, 1997; Finalamended report 09/12
Available from CIRPPG-5 Lanolin Wax Glyceride 1 not in current use* IJT 16(S3):307-316,
1997; Final amendedreport 09/12
Available from CIRPPG-5-Laureth-5 1 safe when formulated
to be non- irritatingFinal report 09/2013Available from CIR
PPG-69 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
PPG-6 C12-15 Pareth-12 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-6 C12-18 Pareth-11 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-6 C9-11 Pareth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-6 Deceth-4 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-6 Deceth-9 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-6-Decyltetradeceth-12 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-6-Decyltetradeceth-20 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-6-Decyltetradeceth-30 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-6-Laureth-3 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-6 Trideceth-8 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-7 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
PPG-8-Ceteth-1 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-8-Ceteth-10 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-8-Ceteth-2 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-8-Ceteth-20 1 safe when formulatedto be non- irritating
Final report 09/2013Available from CIR
PPG-8-Ceteth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-8-Deceth-6 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-9 1 safe when formulatedto be non- irritating
JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012
PPG-9-Buteth-12 1 not in current use* IJT 19 (S1):47-67,2000
PPG-9 Butyl Ether 1 safe when formulatedto be non- irritating
IJT 20(S4):39-52,2001
PPG-9 Diethylmonium Chloride 1 IJT 18(S3):57-59,1999
PPG-9-Ethylhexeth-5 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
PPG-9-Steareth-3 1 not in current use* safe when formulatedto be non-irritating
Final report 09/2013Available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
p-Phenylenediamine (amended)** 1 up to 0.04% Final AmendedReport 12/07
Available from CIRJACT 4(3):203-66,
1985 (original report)p-Phenylenediamine HCl 1 not in current use* Final Amended
Report 12/07Available from CIRJACT 4(3):203-66,
1985 (original report)p-Phenylenediamine Sulfate (amended) 1 not in current use* Final Amended
Report 12/07Available from CIRJACT 4(3):203-66,
1985 (original report)Proline 1 0.00001 to 2% IJT 32(S4):41-64,
2013Propane 1 up to 24% JACT 1(4):127-42,
1982 confirmed06/02 IJT
24(S1):52-55, 2005Propionyl collagen amino acids 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRPropyl Acetate 1 0.005 to 39% IJT 31(S1):112- 136,
2012Propyl Alcohol 1 0.0001 to 0.5% IJT 31(S1):112 -136,
2012Propyl Benzoate 1 not in current use * IJT 31 (3):342-372
(2012)Propylene Carbonate 1 up to 6% JACT 6(1):23-51,
1987 confirmed09/04 IJT 25(S2),
2006Propylene Glycol 1 50% JACT 13(6):437-91,
1994; IJT 31(2)245-260, 2012
Propylene Glycol Behenate* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
Propylene Glycol Capreth-4 1 not in current use* safe for use when formulatedto be non-irritating
Final report 09/2013Available from CIR
Propylene Glycol Caprylate* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
Propylene Glycol Cocoate* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
Propylene Glycol Dicaprate 1 safe when formulatedto be non- irritating
IJT 18 (S2):35-52,1999; Final report12/2014 available
from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Propylene Glycol Dicaproate 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
Propylene Glycol Dicaprylate 1 safe when formulatedto be non- irritating
IJT 18(S2):35-52,1999; Final report12/2014 available
from CIRPropylene Glycol Dicaprylate/dicaprate 1 safe when formulated
to be non-irritatingIJT 18(S2):35-52,1999; Final report12/2014 available
from CIRPropylene Glycol Dicocoate* 1 safe when formulated
to be non- irritatingIJT 18 (S2):35-52,1999; Final report12/2014 available
from CIRPropylene Glycol Diethylhexanoate 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPropylene Glycol Diisononanoate* 1 safe when formulated
to be non- irritatingIJT 30(Suppl.
3):228-269, 2011;Final report 12/2014
available from CIRPropylene Glycol Diisostearate* 1 safe when formulated
to be non- irritatingIJT 18(S2):35-52,1999; Final report12/2014 available
from CIRPropylene Glycol Dilaurate* 1 safe when formulated
to be non- irritatingIJT 18 (S2):35-52,1999; Final report12/2014 available
from CIRPropylene Glycol Dioleate 1 safe when formulated
to be non- irritatingIJT 18 (S2):35-52,1999; Final report12/2014 available
from CIRPropylene Glycol Dipelargonate 1 safe when formulated
to be non- irritatingIJT 18(S2):35-52,1999; Final report12/2014 available
from CIRPropylene Glycol Distearate* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPropylene Glycol Diundecanoate* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPropylene Glycol Heptanoate* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPropylene Glycol Isodeceth-12 1 not in current use* safe for use when formulated
to be non-irritatingFinal report 09/2013Available from CIR
Propylene Glycol Isodeceth-4 1 not in current use* safe for use when formulatedto be non-irritating
Final report 09/2013Available from CIR
Propylene Glycol Isostearate 1 safe when formulatedto be non- irritating
IJT 18(S2):35-52,1999; Final report
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
12/2014 availablefrom CIR
Propylene Glycol Laurate 1 safe when formulatedto be non- irritating
IJT 18 (S2):35-52,1999; Final report12/2014 available
from CIRPropylene Glycol Laureth-6 1 not in current use* Final report 09/2013
Available from CIRPropylene Glycol Linoleate* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPropylene Glycol Linolenate* 1 safe when formulated
to be non- irritatingFinal report 12/2014
available from CIRPropylene Glycol Myristate 1 safe when formulated
to be non- irritatingIJT 18 (S2):35-52,
1999; IJT29(S3) :162-186,2010;
Final report 12/2014available from CIR
Propylene Glycol Oleate 1 safe when formulatedto be non- irritating
IJT 18 (S2):35-52,1999; Final report12/2014 available
from CIRPropylene Glycol Oleate SE 1 up to 50% IJT 18 (S2):35-52,
1999Propylene Glycol Oleate SE (self-emulsifying)* 1 safe when formulated
to be non-irritatingFinal report 12/2014
available from CIRPropylene Glycol Oleth-5 1 not in current use* safe as used when formulated
to be non-irritatingFinal report 09/2013Available from CIR
Propylene Glycol Soyate* 1 safe when formulatedto be non- irritating
Final report 12/2014available from CIR
Propylene Glycol Stearate 1 safe when formulatedto be non- irritating
JACT 2 (5):101-124,1983 confirmed
09/02 IJT24(S1):85-87, 2005;Final report 12/2014
available from CIRPropylene Glycol Stearate SE 1 safe when formulated
to be non- irritatingJACT 2(5):101-124,
1983 confirmed09/02 IJT
24(S1):85-87, 2005;Final report 12/2014
available from CIRPropyl Gallate (Amended) 1 0.10% IJT 26(S3) 2007
JACT 4(3):23-64,1985 (original report)
Propyl Glycolate 1 Glycolic and Lactic Acid,their common salts and their
simple esters, are safe foruse in cosmetic products at
IJT 17(S1):1-242,1998
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
concentrations <=10%, at finalformulation pH >=3.5, when
formulated to avoid increasingsun sensitivity or when
directions for use include thedaily use of sun protection.These ingredients are safefor use in salon products atconcentrations <=30%, at
final formulation pH >=3.0,in products designed forbrief, discontinuous use
followed by thorough rinsingfrom the skin, when applied
by trained professionals,and when application is
accompanied by directions forthe daily use of sun protection.
Propylheptyl Caprylate 1 safe as used in cosmeticswhen formulated
to be non-irritating
Final report 03/2013available from CIR
Propylparaben (amended) 1 up to 0.4% if used alone;parabens mixture up to 0.8%
IJT 27(S4): 1-82,2008 JACT
3(5):147-209, 1984(original report)
Prunus Amygdalus Dulcis (Sweet Almond) Oil 1 0.0001 to 77% Final amended report03/11 available
from CIR; JACT2(5):85-99, 1983;
re-review IJT24(S1):98-101, 2005
Prunus Amygdalus Dulcis (Sweet Almond) OilUnsaponifiables
1 not in current use * Final report 03/11available from CIR
Prunus Amygdalus Dulcis (Sweet Almond) Seed Meal (akaAlmond Meal)
1 up to 76% JACT 2(5):85-99,1983 confirmed
11/02 IJT24(S1):98-101, 2005
Prunus Armeniaca (Apricot) Kernel Oil 1 0.00001 to 89% Final report 03/11available from CIR
Prunus Armeniaca (Apricot) Kernel Oil Unsaponifiables 1 not in current use * Final report 03/11available from CIR
Prunus Avium (Sweet Cherry) Seed Oil 1 0.01 to 0.02% Final report 03/11available from CIR
Prunus Domestica Seed Oil 1 up to 0.04% Final report 03/11available from CIR
Prunus Persica (Peach) Kernel Oil 1 0.003 to 22% Final report 03/11available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Pseudoalteromonas exopolysaccharides 1 not in current use* Final report 09/12available from CIR
Pullulan 1 0.03 to 17% Final report 09/12available from CIR
Pumpkin Seed Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Punica Granatum Seed Oil 1 0.001 to 1% Final report 03/11available from CIR
Punica Granatum Sterols 1 not in current use* Final report 12/2013available from CIR
PVM/MA Copolymer (amended) 1 up to 13% IJT 30 (S2):128-144,2011
PVP 1 up to 35% IJT 17 (S4):95-130,1998
PVP/Dimethylaminoethyl Methacrylate Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Pyrocatechol (Amended) 1 1 carcinogen; potentialco- carcinogen. NOTE:
for hair dyes, insuff.data to support safety.
IJT16(S1):11-58,1997JACT 5(3):123-65,
1986 (OriginalReport)
Pyrogallol 1 up to 5% JACT 10(1):67-85,1991
Pyromallitic Glycidyl Dimethacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Pyrophyllite 1 not in current use* IJT 22 (S1):37-102,2003
Pyrus Malus (Apple) Seed Oil X concentration not reported* Final report 03/11available from CIR
Quassin 1 IJT 27 (S1):1-43,2008
Quaternium-15 (amended) 1 safe at concentrationsnot to exceed 0.2%
JACT 5(3):61-101,1986 (original
report); Amendedsafety assessment03/09 - Available
from CIR; confirmed03/2011
Quaternium-18 1 up to 2% JACT 1(2):71-83,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Quaternium-18 Bentonite 1 up to 9% JACT 1 (2):71-83,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Quaternium-18 Hectorite (amended) 1 0.05 to 5% in leave-on; concentration notreported for rinse-off
IJT 32(S4):33-40,2013 ; JACT
1(2):71-83 (originalreport), 1982
confirmed 11/01 IJT22(S1):1-35, 2003
Quaternium-22 1 up to 5% JACT 14(6):485-97,1995 confirmed
04/10Quaternium-26 1 should not be used in
products in which N-nitrosocompounds may be formed
IJT 19(S1):69-75,2000
Rapeseed Acid 1 not in use at the time* Final report 03/11available from CIR
Rapeseed oil PEG-20 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Rapeseed oil PEG-3 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT33(Spump4):13-39,
2014Raspberry seed oil PEG-8 esters 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014Resorcinol 1 up to 5% JACT 5(3):167-203,
1986 confirmed12/06
Retinol 1 up to 5% JACT 6(3):279-320,1987 confirmed
06/05Retinyl Palmitate 1 up to 5% JACT 6(3):279-320,
1987 confirmed06/06
Rhamnose 1 Final report 03/2014available from CIR
Rhizobian gum 1 concentration not reported* Final report 09/12available from CIR
Rhus Succedanea Fruit Wax 0 up to 34% JACT 3 (3):1-41,1984 confirmed
06/03 IJT24(S1):48-52, 2005
Ribes Nigrum (Black Currant) Seed Oil 1 0.000001 to 0.3% Final report 03/11available from CIR
Ribes Rubrum (Currant) Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Ribose 1 Final report 03/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Rice Amino Acids 1 IJT 33(S4):5-12,2014
Rice bran Acid 1 not in use at the time* Final report 03/11available from CIR
Ricebranamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Ricinoleamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Ricinoleamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Ricinoleamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Ricinoleamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Ricinoleic Acid 1 concentration not reported* IJT 26(S3) 2007Ricinus Communis (Castor) Seed Oil 1 up to 81% IJT 26(S3) 2007Rosa Canina Fruit Oil 1 0.001 to 19% Final report 03/11
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Rosmarinus officinalis (rosemary) extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) flower/leaf/stem extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) flower/leaf/stem water 1 not in current use* safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) flower extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) leaf 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) leaf extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) leaf oil 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) leaf powder 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) leaf water 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rosmarinus officinalis (rosemary) water 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.
Final report 06/14available from CIR
Rubus Chamamorus Seed Oil 1 up to 0.1% Final report 03/11available from CIR
Rubus Idaeus (Raspberry) Seed Oil 1 0.1 to 5% Final report 03/11available from CIR
Safflower (Carthamus Tinctorius) Oil 1 up to 84% JACT 4(5):171-97,1985 confirmed
02/04 IJT 25(S2),2006
Safflower Acid 1 Final report 03/11available from CIR
Safflower seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Salicylic Acid 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,
IJT 22(3):1-108
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
directions for use include thedaily use of sun protection.
Schinziophyton Rautaneii Kernel Oil 1 concentration not reported* Final report 03/11available from CIR
Schinziophyton Rautanenii Kernel Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Sclerocarya Birrea Seed Oil 1 up to 1% Final report 03/11available from CIR
Sclerocarya Birrea Seed Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Sclerotium gum 1 0.003 to 2% Final report 09/12available from CIR
SD Alcohol 30 1 not in current use* IJT 27 (S1):1-43,2008
SD Alcohol 39 1 IJT 27 (S1):1-43,2008
SD Alcohol 39-B 1 concentration not reported* IJT 27 (S1):1-43,2008
SD Alcohol 39-C 1 up to 88% IJT 27 (S1):1-43,2008
SD Alcohol 3-A 1 up to 5% IJT 27 (S1):1-43,2008
SD Alcohol 40 1 IJT 27 (S1):1-43,2008
SD Alcohol 40-B 1 up to 99% IJT 27 (S1):1-43,2008
SD Alcohol 40C 1 not in use at the time* IJT 27 (S1):1-43,2008
SD Alcohol 40-C 1 not in current use* IJT 27 (S1):1-43,2008
Sebacic Acid 1 up to 0.03% in leave-on; up to 1% in rinse- off
IJT 31 (S1):5-76,2012
Serine 1 0.00003 to 2% IJT 32(S4):41-64,2013
Sesame Amino Acids 1 IJT 33(S4):5-12,2014
Sesame Seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Sesamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
IJT 32(S1):36-58,2013
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
products in which N-nitrosocompounds may be formed
Sesamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Sesamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Sesamum Indicum (Sesame) Seed Butter 1 not in use at the time* Final report 03/11available from CIR
Sesamum Indicum (Sesame) Seed Oil (amended) 1 0.0001 to 73% Final amended report03/11 available
from CIR; JACT12(3):261-77, 1993
(original report); IJT30 (1): 40-53, 2011
(amended)Sesamum Indicum (Sesame) Seed Oil Unsaponifiables(amended)
1 0.01 to 0.03% Final amended report03/11 available
from CIR; JACT12(3):261-77, 1993
(original report); IJT30 (1): 40-53, 2011
(amended)Shea butteramide/castoramide DEA 1 safe in the present practices
of use and concentrationwhen formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Shea butteramidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Shellac 1 6% JACT 5(5):309-327,1986 confirmed
12/06; IJT30(S2):73-127, 2011
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Silica (amorphous) 1 up to 44% Final Report 09/09available from CIR
Silica dimethyl silylate 1 safe when formulatedand delivered in the
final product not to beirritating or sensitizingto the respiratory tract
IJT 32(S1):5-24,2013
Silica silylate 1 safe when formulatedand delivered in the
final product not to beirritating or sensitizingto the respiratory tract
IJT 32(S1):5-24,2013
Silicone quaternium-16/glycidoxy dimethicone crosspolymer 1 0.003 to 3% IJT 33 (S2): 65-115,2014
Silk amino acids 1 IJT 33(S4):5-12,2014
Silver borosilicate 1 not in current use* IJT 32(S3): 65-72,2013
Silybum Marianum Seed Oil [Thistle] 1 up to 0.5% Final report 03/11available from CIR
Simmondsia Chinensis (Jojoba) Butter (amended) 1 up to 6% Amended FinalReport 09/08 -
available from CIRSimmondsia Chinensis (Jojoba) Seed Oil (amended) 1 up to 100% Amended Final
Report 09/08 -available from CIRJACT 11(1):57-74,
1992 (original report)Simmondsia Chinensis (Jojoba) Wax (amended) 1 up to 2% Amended Final
Report 09/08 -available from CIRJACT 11(1):57-74,
1992 (original report)Sodium/TEA C12-13 Pareth-3 Sulfate 1 not in current use* safe as used when formulated
to be non-irritating. Theingredients should not
be used in cosmeticproducts in which N-nitroso
compounds can be found
IJT 32(S1): 59-81,2013
Sodium/TEA-lauroyl collagen amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
sodium/TEA-lauroyl keratin amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
sodium/TEA-undecylenoyl collagen amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Acetate 1 0.0002 to 0.5% IJT 31(S1):112 -136,2012
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Acrylates/Acrolein Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Sodium Acrylates/C10-30 Alkyl Acrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Sodium Acrylates/Vinyl Isodecanoate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Sodium Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Sodium Acrylates Crosspolymer-2 1 safe in the present practices ofuse and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Sodium Alpha-Olefin Sulfonates (e.g. C12-14 Olefin) 1 safe as used in rinse offproducts; safe up to 2% in
leave ons; the gamma sultoneimpurities should not exceed
10 ppm for unsubstitutedalkane sultones, 1 ppm for
chlorosultones, and 0.1 ppmfor unsaturated sultones
IJT 17(S5):39-66,1998
Sodium Ascorbate 1 up to 0.3% IJT 24(2):51-111,2005
Sodium Ascorbyl Phosphate 1 up to 3% IJT 24 (2):51-111,2005
Sodium Aspartate 1 not in current use* IJT 32(S4):41-64,2013
Sodium Astrocaryum Murumuruate 1 0.002 to 0.005% Final report 03/11available from CIR
Sodium Avocadoate 1 concentration not reported* Final report 03/11available from CIR
Sodium Babassuate 1 8% Final report 03/11available from CIR
Sodium Benzoate 1 0.000001 to 1% Amended finalreport available
from CIR 09/11; IJT20(S3):23-50, 2001
Sodium Bicarbonate 1 greater than 50% JACT 6 (1):121-138,1987 confirmed
03/05 IJT 25(S2),2006
Sodium Bisulfite 1 up to 0.7% IJT 22(S2):63-88,2003
Sodium Borate 1 5%; but not for use oninfant or injured skin
JACT 2(7):87-125,1983 confirmed
06/03 IJT 25(S2),2006
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Bromate 1 10.17% JACT 13(5):400-14,1994
Sodium Butyl Ester of PVM/MA Copolymer (amended) 1 not in current use* Amended FinalReport 06/09
Available from CIRJACT 12(3):243-56,
1993 (original report)Sodium C10-15 Pareth Sulfate 1 safe when formulated
to be non- irritatingIJT
29(S3) :151-161,2010Sodium C12-13 Pareth Sulfate 1 safe when formulated
to be non- irritatingIJT
29(S3) :151-161,2010Sodium C12-14 Olefin Sulfonate 1 safe as used in rinse off
products; safe up to 2% inleave ons; the gamma sultoneimpurities should not exceed
10 ppm for unsubstitutedalkane sultones, 1 ppm for
chlorosultones, and 0.1 ppmfor unsaturated sultones
IJT 17(S5):39-66,1998
Sodium C12-15 Pareth Sulfate 1 safe when formulatedto be non- irritating
IJT29(S3) :151-161,2010
Sodium C14-16 Olefin Suifonate 1 safe as used in rinse offproducts; safe up to 2% in
leave ons; the gamma sultoneimpurities should not exceed
10 ppm for unsubstitutedalkane sultones, 1 ppm for
chlorosultones, and 0.1 ppmfor unsaturated sultones
IJT 17(S5):39-66,1998
Sodium C14-18 Olefin Sulfonate 1 safe as used in rinse offproducts; safe up to 2% in
leave ons; the gamma sultoneimpurities should not exceed
10 ppm for unsubstitutedalkane sultones, 1 ppm for
chlorosultones, and 0.1 ppmfor unsaturated sultones
IJT 17(S5):39-66,1998
Sodium C16-18 Olefin Sulfonate 1 safe as used in rinse offproducts; safe up to 2% in
leave ons; the gamma sultoneimpurities should not exceed
10 ppm for unsubstitutedalkane sultones, 1 ppm for
chlorosultones, and 0.1 ppmfor unsaturated sultones
IJT 17(S5):39-66,1998
Sodium caproyl prolinate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
sodium capryloyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Carbonate 1 up to 25% JACT 6(1):121-38,1987 confirmed
03/05 IJT 25(S2),2006
Sodium carboxymethyl beta-glucan 1 0.0001 to 0.1% Final report 09/12available from CIR
Sodium carboxymethyl dextran 1 concentration not reported* Final report 09/12available from CIR
Sodium Cellulose Sulfate 1 not in use at the time* Amended safetyassesment 03/09
available from CIRSodium Cetearyl Sulfate 1 up to 10% IJT 29(S2): 115-132,
2010 JACT11(1):145-55, 1992
(original report)Sodium Cetyl Sulfate 1 up to 2% IJT 29(S2): 115-132,
2010Sodium citrate 1 0.000005 to 10% IJT 33 (S2): 16-46,
2014Sodium Coceth Sulfate 1 safe in the present practices of
use and concentration whenformulated to be non-irritating
IJT29(S3) :151-161,2010
Sodium Coco/Hydrogenated Tallow Sulfate (amended) 1 not in current use* Amended FinalReport 09/08
Available from CIRSodium Cocoa Butterate 1 not in use at the time* Final report 03/11
available from CIRSodium Cocoamphoacetate 1 0.09 to 18% JACT 9 (2):121-142,
1990; re-review IJT27(Suppl. 1):77-142,
2008Sodium Cocoamphopropionate 1 0.3 to 10% JACT 9 (2):121-142,
1990; re-review IJT27(Suppl. 1):77-142,
2008Sodium Cocoate (amended) 1 1 to 52% IJT 30 (S1):5S-16SSodium Cocomonoglyceride Sulfate (amended) 1 not in current use* IJT 30(S1):5S-16SSodium Coco-Sulfate 1 up to 29% IJT 29(S2): 115-132,
2010Sodium cocoyl/hydrogenated tallow glutamate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRsodium cocoyl/palmoyl/sunfloweroyl glutamate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium Cocoyl Alaninate 1 safe for use in cosmetics
when formulatedto be non- irritating
Final report 12/2013available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Cocoyl Amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cocoyl Apple amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cocoyl barley amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cocoyl collagen amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium cocoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium cocoyl glutaminate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium cocoyl glycinate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cocoyl Isethionate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
JACT 12(5):459-79,1993 reopened 03/09;
final report 09/2013available from CIR
sodium cocoyl oat amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
sodium cocoyl proline 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cocoyl Sarcosinate 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Sodium cocoyl threoninate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium cocoyl wheat amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Cumenesulfonate 1 up to 3% IJT 30 (S3):270-283,2011
Sodium Deceth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Sodium Decylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
JACT 12(3):279-309,1993 (original
report); IJT 29 (S4)288-305, 2010
Sodium Decyl Sulfate 1 concentration not reported* IJT 29(S2): 115-132,2010
Sodium Dehydroacetate 1 up to 0.6% JACT 4 (3):123-159,1985 confirmed
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
11/03 IJT 25(S2),2006
Sodium dextran sulfate 1 0.005 to 0.5% Final report 09/12available from CIR
Sodium Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
JACT 12(3):279-309,1993 (original
report); IJT 29 (S4)288-305, 2010
Sodium Erythorbate 1 up to 1% IJT 18(S3):1-26,1999
Sodium Ethyl Ester of PVM/MA Copolymer (amended) 1 not in current use* Amended FinalReport 06/09
Available from CIRJACT 12(3):243-56,
1993 (original report)Sodium Ethylhexyl Sulfate 1 not in current use* IJT 29(S2): 115-132,
2010Sodium Formate 1 Final report 12/2013
available from CIRSodium Fumarate 1 not in current use* Final report 03/09
available from CIRSodium Gluconate 1 Final report 03/2014
available from CIRSodium Glutamate 1 0.01 to 2% IJT 32(S4):41-64,
2013Sodium Glycinate 1 concentration not reported* IJT 32(S4):41-64,
2013Sodium Glycolate 1 Glycolic and Lactic Acid,
their common salts and theirsimple esters, are safe for
use in cosmetic products atconcentrations <=10%, at finalformulation pH >=3.5, when
formulated to avoid increasingsun sensitivity or when
directions for use include thedaily use of sun protection.These ingredients are safefor use in salon products atconcentrations <=30%, at
final formulation pH >=3.0,in products designed forbrief, discontinuous use
followed by thorough rinsingfrom the skin, when applied
by trained professionals,and when application is
IJT 17(S1):1-242,1998
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
accompanied by directions forthe daily use of sun protection.
Sodium Grapeseedate 1 concentration not reported* Final report 12/10available from CIR
Sodium Hexametaphosphate 1 safe for use when formulatedto avoid skin irritation
IJT 20(S3):75-89,2001
Sodium Hyaluronate 1 up to 2% IJT 28 (1): 5- 67,2009
Sodium Hydrogenated Cocoate (amended) 1 not in current use* IJT 30(S1):5S-16SSodium Hydrogenated Cocoyl Methyl Isethionate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRSodium Hydrogenated Palmate 1 not in use at the time* Final report 03/11
available from CIRSodium hydrogenated tallowoyl glutamate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium Iodate 1 JACT 14(3):231-39,
1995Sodium Isethionate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/13
available from CIRSodium Lactate 1 Glycolic and Lactic Acid,
their common salts and theirsimple esters, are safe for
use in cosmetic products atconcentrations <=10%, at finalformulation pH >=3.5, when
formulated to avoid increasingsun sensitivity or when
directions for use include thedaily use of sun protection.These ingredients are safefor use in salon products atconcentrations <=30%, at
final formulation pH >=3.0,in products designed forbrief, discontinuous use
followed by thorough rinsingfrom the skin, when applied
by trained professionals,and when application is
accompanied by directions forthe daily use of sun protection.
IJT 17(S1):1-242,1998
Sodium Laneth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Sodium Lauraminopropionate 1 IJT 16(S1):1-10,1997
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Laureth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Sodium Lauriminodipropionate 1 0.05% (rinse-off) IJT 32 (S3):49-55,2013; original report
IJT 16(S1):1-10,1997Sodium lauroyl/myristoyl aspartate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium lauroyl aspartate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium lauroyl collagen amino acids 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium lauroyl glutamate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium Lauroyl Isethionate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRSodium Lauroyl Methyl Isethionate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2013
available from CIRSodium lauroyl millet amino acids 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium lauroyl oat amino acids 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 12/2013
available from CIRSodium Lauroyl Sarcosinate 1 safe as used in rinse-off
products; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Sodium lauroyl silk amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium lauroyl wheat amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Lauryl Phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Sodium Lauryl Sulfate 1 safe for use in rinse-off products; but 1%for leave-on products
JACT 2(7):127-181,1983 confirmed
06/02 IJT24(S1):89-98, 2005
Sodium Lauryl Sulfoacetate 1 up to 21% JACT 6 (3):261-277,1987 confirmed
12/04 IJT 25(S2),2006
Sodium Macadamiaseedate 1 not in use at the time* Final report 03/11available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Magnesium Silicate 1 up to 5% IJT 22 (S1):37-102,2003
Sodium Malate 1 safe for use as pH adjusters;insufficient data to support
safety for other uses
IJT 20(S1):47-55,2001
Sodium Mangoseedate 1 concentration not reported* Final report 03/11available from CIR
Sodium Metabisulfite 1 up to 14% IJT 22(S2):63 -88,2003
Sodium Metaphosphate 1 safe for use when formulatedto avoid skin irritation
IJT 20(S3):75-89,2001
Sodium Metasilicate 1 up to 14% safe for use when formulatedto avoid skin irritation
IJT 24(S1):103-117,2005
Sodium methyacrylate/styrene copolymer 1 not in current use* Final report 09/2014available from CIR
Sodium Methyl Isethionate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Sodium-m-Nitrobenzenesulfonate 1 JACT 15(4):337-47,1996
Sodium Myreth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Sodium Myristate 1 up to 6% IJT 29(S3):162-186,2010
Sodium myristoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Myristoyl Isethionate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Sodium Myristoyl Sarcosinate 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Sodium Myristyl Sulfate 1 concentration not reported* IJT 29(S2): 115-132,2010
Sodium Naphthalenesulfonate (amended) 1 below 2% safe as used in cosmeticformulations intended tobe applied to skin; but
insufficient data to support thesafety in cosmetic productswhich may contact mucousmembranes or be ingested.
IJT 22(S2):37-44,2003
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Octoxynol-2 Ethane Sulfonate 1 not in current use* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Sodium Octoxynol-2 Sulfate 1 not in current use* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Sodium Octoxynol-6 Sulfate 1 not in current use* safe as used in rinse-off products; safe at 5%
in leave-on products
IJT 23(S1):59-111,2004
Sodium Octoxynol-9 Sulfate 1 not in current use* IJT 23(S1):59-111,2004
Sodium Oleoyl Isethionate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Sodium Oleth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Sodium Oleyl Methyl Isethionate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Sodium Oleyl Sulfate 1 not in current use* IJT 29(S2): 115-132,2010
Sodium Olivate 1 4 to 18% Final report 03/11available from CIR
Sodium olivoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Palmate 1 3 to 68% Final report 03/11available from CIR
Sodium palmitoyl proline 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Palm Kernelate 1 12 to 44% Final report 03/11available from CIR
Sodium Palm Kerneloyl Isethionate 1 not in current use* Final report 09/2013available from CIR
Sodium palmoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium PCA 1 should not be used in cosmeticproducts in which N-nitrosocompounds can be formed
IJT 18(S2):25-34,1999; Final report12/2014 available
from CIRSodium p-Chloro-m-Cresol (amended) 1 up to 0.5% IJT 25(S1):29-127,
2006Sodium Peanutate 1 not in current use* Final report 03/11
available from CIRsodium PEG-50 hydrogenated castor oil succinate 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014Sodium Persulfate 1 safe as oxidizing agents
in hair colorants andlighteners designed forbrief, discontinuous use
IJT 20(S3):7-21,2001
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
followed by thoroughrinsing from hair and skin
Sodium Picramate (amended) 1 concentration not reported* IJT 28(S3): 205-216,2009 JACT
11(4):447-64, 1992(original report)
Sodium Polyacrylate 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Sodium Polynaphthalenesulfonate (amended) 1 safe as used in cosmeticformulations intended to be
applied to skin (0.3% is max.use concentration reportedin skin care products); but
insufficient data to support thesafety in cosmetic productswhich may contact mucousmembranes or be ingested.
IJT 22(S2):37-44,2003
Sodium Potassium Aluminum Silicate 1 up to 4% Final Report 09/09available from CIR
Sodium rapeseedate 1 not in current use* Final report 03/11available from CIR
Sodium Ricinoleate 1 concentration not reported* IJT 26(S3): 31-77,2007
Sodium Safflowerate 1 not in current use* Final report 03/11available from CIR
Sodium Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108,2003
Sodium Sesameseedate (amended) 1 not in current use* Final amended report03/11 available
from CIR; JACT12(3):261-77, 1993
(original report); IJT30 (1): 40-53, 2011
(amended)Sodium Sesquicarbonate 1 greater than 50% JACT 6(1):121-38,
1987 confirmed03/05 IJT 25(S2),
2006Sodium Silicate 1 up to 35% safe for use when formulated
to avoid skin irritationIJT 24(S1):103-117,
2005Sodium Soyate 1 not in current use* Final report 03/11
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Stearate 1 up to 25% JACT 1(2):143-77,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Sodium stearoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Stearoyl Methyl Isethionate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2013available from CIR
Sodium Stearyl Fumarate. 1 not in current use* Final report 03/09available from CIR
Sodium Stearyl Sulfate 1 not reported* IJT 29 (S2): 115-132,2010
Sodium styrene/acrylates/ethylhexyl acrylate/lauryl acrylatecopolymer
1 not in current use* Final report 09/2014available from CIR
Sodium Styrene/Acrylates Copolymer 1 IJT 21(S3):1-50,2002; Final report09/2014 available
from CIRSodium Succinate 1 concentration not reported* IJT 31 (S1):5-76,
2012Sodium Sulfate 1 up to 1% in leave-
on formulationsIJT 19(S1):77-87,
2000Sodium Sulfite 1 up to 3% IJT 22(S2):63-88,
2003Sodium Sweet Almondate 1 up to 15% Final report 03/11
available from CIRSodium Tallate 1 concentration not reported* IJT 28(S3):252-258,
2009Sodium Tallow Sulfate 1 not in current use* IJT 29(S2): 115-132,
2010Sodium Theobroma Grandiflorum Seedate 1 not in current use* Final report 03/11
available from CIRSodium Thioglycolate 1 safe for use in hair
straighteners permanentwaves, tonics, dressings, and
so forth, wave sets, othernoncoloring hair products,and hair dyes and colors, atconcentrations up to 15.2%;
hairdressers should avoidskin contact and minimizeconsumer skin exposure;safe for use in depilitories
when formulated to be non-irritating under conditions
of recommended use.
IJT 28(S3):68-133,2009
Sodium Tocopheryl Phosphate 1 Final report 03/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Sodium Toluenesulfonate 1 not in current use* IJT 30(S3):270-283,2011
Sodium Trideceth Sulfate 1 up to 19% IJT29(S3) :151-161,2010
Sodium Tridecylbenzenesulfonate 1 safe as cosmetic ingredientsin the present practices of
use and concentration whenformulated to be non-irritating
IJT 29(S4):288-305,2010
Sodium Tridecyl Sulfate 1 not in current use* IJT 29(S2): 115-132,2010
Sodium Trimetaphosphate 1 safe for use when formulatedto avoid skin irritation
IJT 20(S3):75-89,2001
Sodium undecylenoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Sodium Xylenesulfonate 1 up to 15% IJT 30 (S3):270-283,2011
Solanum Lycopersicum (Tomato) Fruit Oil 1 0.01 to 1% Final report 03/11available from CIR
Solanum Lycopersicum (Tomato) Seed Oil 1 concentration not reported* Final report 03/11available from CIR
Sorbeth-40 Hexaoleate 1 concentration not reported* IJT 19(S2):43-89,2000
Sorbeth-40 Hexaoleate 1 concentration not reported* IJT 19(S2):43-89,2000
Sorbeth Tetraoleate Laurate 1 concentration not reported* IJT 19(S2):43-89,2000
Sorbeth Tetrastearate 1 concentration not reported* IJT 19(S2):43-89,2000
Sorbic Acid 1 up to 5% JACT 7(6):837-80,1988 confirmed
04/06Sorbitan Caprylate 1 IJT 21(S1):93-112,
2002; Final report12/2014 available
from CIRSorbitan Cocoate* 1 IJT 21 (S1):93-112,
2002; Final report12/2014 available
from CIRSorbitan Diisostearate* 1 IJT 21(S1):93-112,
2002; Final report12/2014 available
from CIRSorbitan Dioleate* 1 IJT 21 (S1):93-112,
2002; Final report12/2014 available
from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Sorbitan Distearate* 1 IJT 21(S1):93-112,2002; Final report12/2014 available
from CIRSorbitan Isostearate 1 IJT 21(S1):93-112,
2002; Final report12/2014 available
from CIRSorbitan Laurate 1 JACT 4(3):65-121,
1985; Final report12/2014 available
from CIRSorbitan Oleate 1 JACT 4(3):65-121,
1985; Final report12/2014 available
from CIRSorbitan Olivate 1 IJT 21(S1):93- 112,
2002; Final report12/2014 available
from CIRSorbitan Palmate 1 Final report 12/2014
available from CIRSorbitan Palmitate 1 JACT 4(3):65-121,
1985; Final report12/2014 available
from CIRSorbitan Sesquicaprylate* 1 Final report 12/2014
available from CIRSorbitan Sesquiisostearate 1 IJT 21 (S1):93-112,
2003; Final report12/2014 available
from CIRSorbitan Sesquioleate 1 JACT 4(3):65 -121,
1985; Final report12/2014 available
from CIRSorbitan Sesquistearate* 1 IJT 21(S1):93-112,
2002; Final report12/2014 available
from CIRSorbitan Stearate 1 JACT 4(3):65-121,
1985; Final report12/2014 available
from CIRSorbitan Triisostearate 1 IJT 21(S1):93-112,
2002; Final report12/2014 available
from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Sorbitan Trioleate 1 JACT 4(3):65-121,1985; Final report12/2014 available
from CIRSorbitan Tristearate 1 JACT 4(3):65-121,
1985; Final report12/2014 available
from CIRSorbitan Undecylenate* 1 Final report 12/2014
available from CIRSoy Acid 1 not in current use* Final report 03/11
available from CIRSoyamide DEA 1 safe in the present practices
of use and concentrationwhen formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Soyamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Soyamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Soy Amino Acids 1 IJT 33(S4):5-12,2014
Soybean oil PEG-20 ester 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Soybean Oil PEG-36 Esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Soybean Oil PEG-8 Esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Soybean Oil Propylene Glycol Esters* 1 safe when formulatedto be non-irritating
Final report 12/2014available from CIR
Soy sterol acetate 1 Final report 12/2013available from CIR
Soytrimonium chloride 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Spirulina Amino Acids 1 not in current use* IJT 33(S4):5-12,2014
Squalane 1 up to 31% JACT 1(2):37-56,1982 confirmed
09/01 IJT22(S1):1-35, 2003
Squalene 1 up to 10% JACT 1(2):37-56,1982 confirmed
09/01 IJT22(S1):1-35, 2003
Steapyrium Chloride 1 0.1 to 3% JACT 10(1):87-97, 1991; IJT
30(S2):73-127, 2011Stearalkonium Chloride 1 up to 7% JACT 1(2):57 -69,
1982 confirmed11/01 IJT
22(S1):1-35, 2003Stearalkonium Hectorite (amended) 1 0.006 to 6% IJT 32(S4):33-40,
2013; IJT19(S2):91-98, 2000
(original report)Stearamide DEA 1 safe in the present practices
of use and concentrationwhen formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Stearamide DIBA-Stearate 1 IJT 20(S3):91-97,2001
Stearamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Stearamidopropyl Betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Stearamidopropyl Dimethicone 1 not in current use* IJT 22(S2):11-35,2003
Stearamidopropyl Dimethylamine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Stearamine 1 JACT 14(3):196-203,1995
Stearamine Oxide 1 safe for use in rinse-off products; but 5%for leave-on products
JACT 13(5):231-45,1994 confirmed
09/09; IJT30(S2):73-127, 2011
Steareth-1 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-10 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-100 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-10 Allyl Ether/Acrylates Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Steareth-11 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-13 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-14 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-15 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-16 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-2 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-20 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-200 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Steareth-25 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-27 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-30 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-4 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-40 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-50 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-60 Cetyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2):169-244(2012)
Steareth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-8 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Steareth-80 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Stearic Acid 1 greater than 50% JACT 6(3):321-401, 1987 confirmed
06/05 IJT 25(S2),2006
Stearic Hydrazide 1 JACT 10(1):99-101,1991
Stearoxy Dimethicone 1 IJT 22(S2):11- 35,2003; Final report12/2014 available
from CIRStearoxymethicone/dimethicone Copolymer 1 Final report 12/2014
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Stearoxypropyltrimonium chloride 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Stearoyl ethyltrimonium methosulfate 1 safe when formulatedto be non-irritating
IJT 31(S3): 296-341(2012)
Stearoyl glutamic acid 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Stearoyl leucine 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
Stearoyl Sarcosine 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products
where these ingredientsare likely to be inhaled.
IJT 20(S1):1-14,2001
Steartrimonium Bromide 1 safe when formulatedto be non- irritating
IJT 31(S3): 296-341(2012)
Steartrimonium Chloride 1 up to o.25% for leave-on products (no rinse-
off uses reported)
IJT 16(S3):195-220,1997; IJT 31(S3):
296-341 (2012)Steartrimonium methosulfate 1 safe when formulated
to be non- irritatingIJT 31(S3): 296-341
(2012)Stearyl/Lauryl Methacrylate Crosspolymer 1 safe in the present practices of
use and concentration whennot polymerized in benzene
Final report 11/2011available from CIR
Stearyl Acetate 1 0.2 to 0.5% IJT 31(S1):112- 136,2012
Stearyl Alcohol 1 up to 25% JACT 4(5):1-29,1985 confirmed
03/04 IJT 25(S2),2006
Stearyl Beeswax 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Stearyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2): 141-146,2012; final report03/2013 available
from CIRStearyl Benzoate 1 2% IJT 31(3):342-372
(2012)Stearyl betaine 1 concentration not reported* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2014
available from CIRStearyl Caprylate 1 0.1 to 1% safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2): 141-146,
2012; final report03/2013 available
from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Stearyl citrate 1 0.007 to 12% IJT 33 (S2): 16 -46,2014
Stearyl Dimethicone 1 up to 6% IJT 22(S2):11- 35,2003
Stearyl Erucate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Stearyl Ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Stearyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012
Stearyl Glycyrrhetinate 1 up to 1% IJT 26 (S2):79-112,2007
Stearyl Heptanoate (amended) 1 0.07 to 8% JACT 14(6):497-510,1995; IJT 31(S2):
141-146, 2012;final report 03/2013available from CIR
Stearyl Linoleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Stearyl Methicone 1 up to 6% IJT 22(S2):11-35,2003
Stearyl Olivate 1 concentration not reported* safe for use in cosmetics whenformulated to be non-irritating
IJT 31(S2): 141-146,2012; final report03/2013 available
from CIRStearyl Palmitate 1 up to 3% safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2): 141-146,
2012; final report03/2013 available
from CIRStearyl Phosphate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 09/2014
available from CIRStearyl Stearate 1 0.02 to 4% safe for use in cosmetics when
formulated to be non-irritatingIJT 31(S2): 141-146,
2012; final report03/2013 available
from CIRStyrene/Acrylates/Ammonium Methacrylate Copolymer 1 safe for use when
formulated to avoid irritationIJT 21(S3):1-50,
2002Styrene/acrylates/dimethicone acrylate crosspolymer 1 not in use at the time* IJT 33 (S2): 65-115,
2014Styrene/acrylates/ethylhexyl acrylate/lauryl acrylatecopolymer
1 not in current use* Final report 09/2014available from CIR
Styrene/Acrylates Copolymer 1 IJT 21(S3):1-50,2002; Final report09/2014 available
from CIRStyrene/butadiene copolymer 1 Final report 09/2014
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Styrene/isoprene copolymer 1 not in current use* Final report 09/2014available from CIR
Styrene/methylstyrene copolymer 1 not in current use* Final report 09/2014available from CIR
Styrene/stearyl methacrylate crosspolymer 1 not in current use* Final report 09/2014available from CIR
Styrene/va copolymer 1 not in current use* Final report 09/2014available from CIR
Styrene/vp copolymer 1 Final report 09/2014available from CIR
Succinic Acid 1 up to 0.2% in leave-on;up to 26% in rinse- off
IJT 31 (S1):5-76,2012
Sucralose 1 Final report 03/2014available from CIR
Sucrose 1 Final report 03/2014available from CIR
Sunfloweramide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Sunflower Seed Acid 1 not in use at the time* Final report 03/11available from CIR
Sunflowerseedamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to be non-
sensitizing, which maybe based on a quantitative
risk assessment (QRA)
Final report 06/2014available from CIR
Sunflower seed oil PEG-32 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Sunflower seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Sweet Almond Amino Acids 1 not in current use* IJT 33(S4):5-12,2014
Sweet almond oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Synthetic Beeswax 1 up to 18% JACT 3(3):43-99,1984 confirmed
06/03 IJT24(S1):67-74, 2005
Synthetic Fluorphlogopite 1 0.00002-67% Final report 06/12available from CIR
Synthetic Jojoba Oil (amended) 1 up to 0.1% Amended FinalReport 09/08 -
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Synthetic Wax 1 up to 29% JACT 3(3):43-99,1984 confirmed
06/03 IJT24(S1):67-74, 2005
Talc 1 Final report 03/2013available from CIR
Tallamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Tallamidopropyl Dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Tall Oil Acid (amended) 1 up to 8% IJT 28 (S3):252-258,2009 JACT
8(4):769-776, 1989(original report)
Tall oil sterol 1 Final report 12/2013available from CIR
Tallow 1 greater than 50% JACT 9(2):153-64,1990 confirmed
06/06Tallowamide DEA 1 safe in the present practices
of use and concentrationwhen formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Tallowamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmetic
Final amended report03/12 available from
CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
products in which N-nitrosocompounds may be formed
Tallowamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Tallowamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Tallow Betaine 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2014available from CIR
Talloweth-18 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Talloweth-4 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Talloweth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Talloweth-6 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Talloweth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Tallow Glyceride 1 up to 25% JACT 9(2):153-64,1990 confirmed
06/06Tallow Glycerides 1 JACT 9(2):153-64,
1990 confirmed06/06
Tallowtrimonium chloride 1 IJT 31(S3): 296-341(2012)
TBHQ (originally t-Butyl Hydroquinone) (Amended) 1 safe up to 0.1% JACT 10(1):1-7,1991 JACT
5(5):329-51, 1986(Original report)
t-Butyl Acetate 1 up to 10% IJT 31(S1):112-136,2012
t-Butyl Alcohol (Amended) 1 up to 0.5% IJT 24 (2):1-20, 2005(Amended) JACT8(4):627-41, 1989(Original Report)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
t-Butyl Hydroquinone (now TBHQ) (Amended) 1 0.1% JACT 10(1):1-7,1991 JACT
5(5):329-51, 1986(Original report)
t-Butyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
TEA-C10-15 Alkyl Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA-C11-15 Alkyl Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA-C11-15 Pareth Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA-C12-13 Alkyl Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
IJT 32(S1): 59-81,2013
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
TEA-C12-13 Pareth-3 Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA-C12-14 Alkyl Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA-C12-15 Alkyl Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA-Canolate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
IJT 32(S1): 59-81,2013
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
products in which N-nitrosocompounds can be found.
TEA-Cocoate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA-Coco-Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA-cocoyl alaninate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
TEA-cocoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
TEA-cocoyl glutaminate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
TEA-Cocoyl-Hydrolyzed Collagen (formerlyTriethanolamine-Coco-Hydrolyzed Animal Protein)
1 up to 50% JACT 2(7):75-86,1983 confirmed
11/02 IJT 24(S1):82-85, 2005
TEA-Dodecylbenzenesulfonate (amended) 1 up to 5% JACT 12(3):279-309,1993 (original
report); IJT 29 (S4)288-305, 2010
TEA-EDTA 1 not in current use* IJT 21(S2):95- 142,2002
TEA-Glyceryl Dimaleate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
IJT 32(S1): 59-81,2013
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
products in which N-nitrosocompounds can be found.
TEA-Hydrochloride 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA-Hydrogenated Cocoate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA-hydrogenated tallowoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
TEA-Isostearate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA-Lactate 1 when used as an AHAingredient, safe for use at
concentrations <=10%, at finalformulation pH >=3.5, when
formulated to avoid increasingsun sensitivity or when
directions for use include thedaily use of sun protection.These ingredients are safefor use in salon products atconcentrations <=30%, at
final formulation pH >=3.0,
IJT 17(S1):1-242,1998; IJT 32(S1):
59-81, 2013
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
in products designed forbrief, discontinuous use
followed by thorough rinsingfrom the skin, when applied
by trained professionals,and when application is
accompanied by directions forthe daily use of sun protection.
When used otherwise,safe when formulated tobe non-irritating, except
that this ingredient shouldnot be used in cosmetic
products in which N-nitrosocompounds can be formed.
TEA-Laurate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA-Laurate/Myristate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA-Laureth Sulfate 1 safe as used when formulatedto be non- irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
TEA-lauroyl/myristoyl aspartate* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
TEA-lauroyl collagen amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
TEA-lauroyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
TEA-lauroyl keratin amino acids* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available from CIR
TEA-Lauryl Sulfate 1 safe up to 10.5% JACT 1 (4):143-67,1982; IJT 32(S1):
59-81, 2013TEA-Myristate 1 safe as used when formulated
to be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA-Oleate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA-Oleyl Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA-Palmitate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practices
IJT 32(S1): 59-81,2013
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
of use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
TEA-PEG-3 Cocamide Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA-Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
TEA Sorbate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA Stearate 1 safe for use in rinse-offproducts; but 15% in leave-
on products; and should not beused with N-nitrosating agents
JACT 14(3): 240-8,1995; IJT 32(S1):
59-81, 2013
TEA Sulfate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
IJT 32(S1): 59-81,2013
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
products in which N-nitrosocompounds can be found.
TEA-Tallate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
TEA-Tridecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 29 (S4) 288-305,2010
TEA-Undecylenate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not
exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmetic
products in which N-nitrosocompounds can be found.
IJT 32(S1): 59-81,2013
Tetradecyleicosyl Stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Tetradecyloctadecyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Tetradecyloctadecyl Hexyldecanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Tetradecyloctadecyl Myristate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT29(S3) :162-186,2010;
final report 03/2013available from CIR
Tetradecyloctadecyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Tetradecylpropionates 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Tetrahydrofurfuryl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided;products should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Tetrasodium EDTA 1 less than 1% IJT 21(S2):95- 142,2002
Theobroma Cacao (Cocoa) Seed Butter 1 0.000002 to 37% Final report 03/11available from CIR
Theobroma Grandiflorum Seed Butter 1 0.00005 to 7% Final report 03/11available from CIR
Thiodipropionic Acid (amended) 1 safe for use in cosmeticformulations when formulated
to be non-irritating
IJT 29 (S3): 137-150,2010
Thioglycolic Acid (amended) 1 safe for use in hairstraighteners permanent
waves, tonics, dressings, andso forth, wave sets, other
noncoloring hair products,and hair dyes and colors, atconcentrations up to 15.2%;
hairdressers should avoidskin contact and minimizeconsumer skin exposure;safe for use in depilitories
when formulated to be non-irritating under conditions
of recommended use.
JACT 10(1):135-92,1991 (original
report); IJT28(S3):68-133, 2009
Threonine 1 0.00002 to 0.05% IJT 32(S4):41-64,2013
Thymol (amended) 1 up to 0.5% IJT 25(S1):29-127,2006
Tin(IV) Oxide 1 0.000003 to 1.3% IJT 33(S4):40-46,2014
Tocopherol 1 less than or equal to 5% IJT 21 (S3):51-116,2002; Final report03/2014 available
from CIRTocophersolan 1 less than or equal to 0.2% IJT 21(S3):51-116,
2002; Final report03/2014 available
from CIRTocopheryl Acetate 1 less than or equal to 36%
(100% in Vitamin E oil)IJT 21(S3):51-116,2002; Final report03/2014 available
from CIRTocopheryl Linoleate 1 <= 2% IJT 21(S3):51- 116,
2002; Final report03/2014 available
from CIRTocopheryl Linoleate/Oleate 1 not in current use* IJT 21(S3):51-116,
2002; Final report
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
03/2014 availablefrom CIR
Tocopheryl Nicotinate 1 <= 1% IJT 21(S3):51 -116,2002; Final report03/2014 available
from CIRTocopheryl Phosphate 1 not in current use* Final report 03/2014
available from CIRTocopheryl Succinate 1 concentration not reported* IJT 21(S3):51-116,
2002; Final report03/2014 available
from CIRTocotrienols 1 Final report 03/2014
available from CIRToluene 1 up to 50% in nail
care productsJACT 6(1):77-120,
1987 confirmed03/05 IJT 25(S2),
2006Toluene-2,5-Diamine (amended) 1 up to 3% JACT 11(4):423-45,
1992 (originalreport); IJT
29(S2):61-83, 2010Toluene-2,5-Diamine Sulfate (amended) 1 up to 4% JACT 11(4):423-45,
1992 (originalreport); IJT
29(S2):61-83, 2010Toluene-3,4-Diamine (amended) 1 JACT 11(4):423-45,
1992 (originalreport); IJT
29(S2):61-83, 2010Toluenesulfonamide/Formaldehyde Resin (aka Tosylamide/Formaldehyde Resin)
1 up to 13% JACT 5(5):471-490,1986 confirmed
09/04 IJT 25(S2),2006
Toluenesulfonamide/Formaldehyde Resin-80 1 not in current use* JACT 5(5):471-490,1986 confirmed
09/04 IJT 25(S2),2006
Toluene Sulfonic Acid 1 not in current use* IJT 30(S3):270-283,2011
Torreya Nucifera Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Tragacanth (Astragalus Gummifer) Gum 1 up to 3% JACT 6(1):1-22,1987 confirmed
09/04 IJT 25(S2),2006
Trehalose 1 Final report 03/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Triacetin 1 up to 4% IJT 22(S2):1-10,2003
Triarachidin 1 not in current use* IJT 20 (S4):61-94,2001
Tribehenin 1 up to 6% IJT 20(S4):61-94,2001
Tributyl citrate 1 0.0005 to 9% IJT 33 (S2): 16-46,2014
Tri-C12-13 alkyl citrate 1 concentration not reported* IJT 33 (S2): 16-46,2014
Tri-C14-15 alkyl citrate 1 0.1 to 5% in leave- on IJT 33 (S2): 16-46,2014
Tricaprin 1 not in current use* IJT 20(S4):61- 94,2001
Tricaprylin 1 concentration not reported* IJT 20(S4):61-94,2001
Tricaprylyl citrate 1 0.3 to 27% IJT 33 (S2): 16-46,2014
Tricetyl phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Trichloroethane 1 safe as a solvent, but notin use at the time; EPA has
banned all but essentialuses and FDA has said that
aerosol uses are not essential
IJT 27(S4): 107-138,2008
Triclosan 1 0.04 to 0.3% Final report 12/10available from CIR
Trideceth-10 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-12 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-15 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-18 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-2 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-20 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-21 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Trideceth-2 carboxamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Trideceth-3 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-4 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-5 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-50 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-6 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-7 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-8 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Trideceth-9 1 safe for cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Tridecyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Tridecyl Cocoate (amended) 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
IJT 30(S1):5S-16S;Final report 06/13
available from CIRTridecyl Erucate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRTridecyl Ethylhexanoate 1 safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRTridecyl Isononanoate 1 9% safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRTridecyl Laurate 1 not in current use* safe for use in cosmetics when
formulated to be non-irritatingFinal report 03/2013
available from CIRTridecyl Myristate 1 not in use at the time* safe for use in cosmetics when
formulated to be non-irritatingIJT
29(S3) :162-186,2010;
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Final report 03/2013available from CIR
Tridecyl Neopentanoate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Tridecyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,
or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.
IJT 22(3):1-108
Tridecyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 03/2013available from CIR
Trierucin 1 not in current use* IJT 20(S4):61- 94,2001
Triethanolamine 1 safe for use in rinse-offproducts; but 5% in leave-
on cosmetic products;and should not be usedin products containingN-nitrosating agents
JACT 2(7):183-235,1983; IJT 32(S1):
59-81, 2013
Triethanolamine Cocoyl Hydrolyzed Collagen (formerlyTriethanolamine-Coco-Hydrolyzed Animal Protein)
1 up to 50% JACT 2(7):75-86,1983 confirmed
11/02 IJT 24(S1):82-85, 2005
Triethyl citrate 1 0.0008 to 6% IJT 33 (S2): 16-46,2014
Triethylene Glycol 1 0.0006 to 0.2% Amended FinalReport 06/10 -
available from CIRTriethylene Glycol Dimethacrylate 1 safe in nail enhancement
products when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Triethylhexanoin (aka Trioctanoin) Triisononanoin 1 concentration not reported* IJT 20(S4):61-94,2001
Triethylhexyl citrate 1 concentration not reported* IJT 33 (S2): 16-46,2014
Trifluoropropyl dimethicone/PEG-10 crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Trifluoropropyl dimethicone/trifluoropropyldivinyldimethicone crosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Trifluoropropyl dimethicone/vinyl trifluoropropyldimethicone/silsesquioxane crosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Trifluoropropyldimethyl/trimethylsiloxysilicate 1 safe when formulatedand delivered in the
final product not to beirritating or sensitizingto the respiratory tract
IJT 31(S1):5-24(2013)
Trigonella foenum-graecum hydroxypropyltrimoniumchloride
1 not in current use* Final report 03/12available from CIR
Triheptanoin 1 not in current use* IJT 20 (S4):61-94,2001
Triheptylundecanoin 1 not in current use* IJT 20(S4):61-94,2001
Trihexyldecyl citrate 1 not in current use* IJT 33 (S2): 16-46,2014
Trihydroxystearin 1 up to 5% IJT 19(S1):89-94,2000
Triisocetyl citrate 1 0.6to 3% in leave-on IJT 33 (S2): 16-46,2014
Triisopalmitin 1 not in current use* IJT 20 (S4):61-94,2001
Triisopropanolamine 1 safe for use in cosmeticproducts; but should not beused in products containing
N-nitrosating agents
JACT 6(1):53-76,1987 confirmed
12/04 IJT 25(S2),2006
Triisopropyl citrate 1 not in current use* IJT 33 (S2): 16-46,2014
Triisostearin 1 less than 40% IJT 20(S4):61- 94,2001
Triisostearyl citrate 1 0.3 to 80% in leave-on, concentration notreported for rinse-off
Final report 03/12available from CIR
Trilaurin 1 less than 50% IJT 20(S4):61-94,2001
Trilauryl citrate 1 not in current use* Final report 03/12available from CIR
Trilauryl phosphate 1 not in current use* Final report 09/2014available from CIR
Trilinolein 1 concentration not reported* IJT 20(S4):61-94,2001
Trimethylolpropane Trimethacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should beaccompanied with directions
to avoid skin contactbecause of the sensitizingpotential of methacrylates
IJT 24(S5):53-100,2005
Trimethylsiloxysilicate 1 safe when formulatedand delivered in the
IJT 31(S1):5-24(2013)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
final product not to beirritating or sensitizingto the respiratory tract
Trimethylsiloxysilicate/ dimethicone crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Trimethylsiloxysilicate/dimethiconol crosspolymer 1 up to 2% Final report 12/10available from CIR
Trimyristin 1 concentration not reported* IJT 20(S4):61-94,2001
Trioctyldodecyl citrate 1 1 to 30% in leave- on Final report 03/12available from CIR
Triolein 1 not in current use* IJT 20(S4):61- 94,2001
Trioleyl citrate 1 not in current use* Final report 03/12available from CIR
Trioleyl phosphate 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Tripalmitin 1 concentration not reported* IJT 20(S4):61-94,2001
Tripalmitolein 1 not in current use* IJT 20 (S4):61-94,2001
Tripeptide-1 1 Final report 06/2014available from CIR
Tripotassium EDTA 1 concentration not reported* IJT 21(S2):95-142,2002
Tripropylene Glycol 1 safe when formulatedto be non- irritating
IJT 31(2) 245-260,2012
Triricinolein 1 not in current use* IJT 20 (S4):61-94,2001
Trisodium EDTA 1 less than 1% IJT 21(S2):95- 142,2002
Trisodium Glycyrrhizate 1 not in current use* IJT 26(S2):79-112,2007
Trisodium HEDTA 1 less than 1% IJT 21(S2):95- 142,2002
Tristearin 1 concentration not reported* IJT 20(S4):61-94,2001
Tristearyl citrate 1 not in current use* Final report 03/12available from CIR
Tristearyl phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 09/2014available from CIR
Triticum Aestivum (Wheat) Germ Oil 1 not in use at the time* Final report 03/11available from CIR
Triticum Vulgare (Wheat) Germ Oil 1 0.0001 to 28% Final amended report03/11 available
from CIR; JEPT4(4):33-45, 1980;
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
re-review IJT22(S1):1-35, 2003
Triticum Vulgare (Wheat) Germ Oil Unsaponifiables 1 up to 0.2% Final report 03/11available from CIR
Triticum Vulgare (Wheat) Gluten 1 less than or equal to 1% JEPT 4(4):5-17, 1980confirmed 06/01 IJT
22(S1):1-35, 2003Triticum Vulgare (Wheat) Kernel Flour 1 up to 1% JEPT 4(4):19-32,
1980 confirmed06/01 IJT
22(S1):1-35, 2003Triticum Vulgare (Wheat) Starch 1 up to 25% JEPT 4(4):19-32,
1980 confirmed06/01 IJT
22(S1):1-35, 2003Triundecanoin 1 not in current use* IJT 20 (S4):61-94,
2001Tromethamine 1 Final report 09/2013
available from CIRTryptophan 1 0.00% IJT 32(S4):41-64,
2013Tyrosine 1 0.0005 to 1% IJT 32(S4):41-64,
2013Umbilical Extract 1 if used, should not deliver
any metabolic/endocrineactivity, and they must be
free of detectable pathogenicviruses or infectious agents
IJT 21(S1):81-91,2002
Undeceth-11 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Undeceth-3 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Undeceth-40 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Undeceth-5 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Undeceth-7 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Undeceth-8 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Undeceth-9 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
Undecylenamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
Final amended report09/11 available from
CIR
Undecylenamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should
not be used in cosmeticproducts in which N-nitrosocompounds may be formed
Final amended report03/12 available from
CIR
Undecylenamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Undecyleneth-6 1 safe for use in cosmeticswhen formulated
to be non- irritating
IJT 31(S2):169-244(2012)
undecylenoyl collagen amino acids 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available for CIR
undecylenoyl glycine 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available for CIR
undecylenoyl phenylalanine 1 safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available for CIR
undecylenoyl wheat amino acids* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available for CIR
Undecylenoyl xanthan gum 1 not in current use* Final report 09/12available from CIR
Undecyl glucoside 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 32 (S3): 22-48,2013
Urea 1 up to 10% IJT 24(S3):1-56,2005
Urethane Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing
this ingredient should be
IJT 24(S5):53-100,2005
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
accompanied with directionsto avoid skin contact
because of the sensitizingpotential of methacrylates
Urocanic Acid 1 JACT 14(5):386-423,1995
VA/Butyl Maleate/Isobornyl Acrylate Copolymer 1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
VA/Crotonates Copolymer (formerly Vinyl Acetate/CrotonicAcid Copolymer)
1 up to 11% JACT 2(5):125-140,1983 confirmed
06/03 IJT 24(S1):101-102, 2005
Vaccinium Corymbosum (Blueberry) Seed Oil 1 not in use at the time* Final report 03/11available from CIR
Vaccinium Macrocarpon (Cranberry) Seed Oil 1 0.002 to 2% Final report 03/11available from CIR
Vaccinium Myrtillus Seed Oil 1 0.01 to 0.1% Final report 03/11available from CIR
Vaccinium Vitis-Idaea Seed Oil 1 concentration not reported* Final report 03/11available from CIR
Valine 1 0.0004 to 1% IJT 32(S4):41-64,2013
Vegetable (Olus) Oil 1 0.0005 to 31% Final report 03/11available from CIR
Vegetable Amino Acids 1 IJT 33(S4):5-12,2014
Vinyl Caprolactam/PVP/ Dimethylaminoethyl MethacrylateCopolymer
1 safe for use whenformulated to avoid irritation
IJT 21(S3):1-50,2002
Vinyl Dimethicone 1 not in current use* IJT 22 (S2):11-35,2003
Vinyl dimethicone/lauryl/behenyl dimethicone crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014
Vinyl dimethicone/lauryl dimethicone crosspolymer 1 0.09 to 2% IJT 33 (S2): 65-115,2014
Vinyl dimethicone/methicone silsesquioxane crosspolymer 1 0.1 to 20% IJT 33 (S2): 65-115,2014
Vinyldimethyl/trimethylsiloxysilicate/dimethiconecrosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Vinyldimethyl/trimethylsiloxysilicate stearyl dimethiconecrosspolymer
1 not in current use* IJT 33 (S2): 65-115,2014
Vitis Vinifera (Grape) 1 0.10% IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) bud extract 1 0.08% IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) flower extract 1 not in current use* IJT 33(S3):48-83,2014
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Vitis Vinifera (Grape) fruit extract 1 0.000001 to 2% IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) fruit powder 1 concentration not reported* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) fruit water 1 0.7 to 0.8% IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) juice 1 0.01 to 2% IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) juice extract 1 concentration not reported* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) leaf/seed/skin extract 1 not in current use* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) leaf extract 1 0.01 to 3% IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) leaf oil 1 not in current use* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) leaf water 1 not in current use* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) leaf wax 1 not in current use* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) root extract 1 not in current use* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) seed 1 0.05 to 0.08% IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) seed extract 1 0.00002 to 0.2%l. IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) Seed Oil 1 0.001 to 43% IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) Seed powder 1 concentration not reported* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) shoot extract 1 0.00% IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) skin extract 1 not in current use* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) skin powder 1 not in current use* IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) vine extract 1 IJT 33(S3):48-83,2014
Vitis Vinifera (Grape) vine sap 1 not in current use* IJT 33(S3):48-83,2014
VP/VA Copolymer 1 up to 12% JACT 2(5):141-59,1983 confirmed
09/03Watermelon seed oil PEG-8 esters 1 safe for use in cosmetics when
formulated to be non-irritatingIJT 33(S4):13-39,
2014Welan Gum 1 not in current use* Final report 09/12
available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Wheat Amino Acids 1 IJT 33(S4):5-12,2014
Wheat Germ Acid 1 concentration not reported* Final report 03/11available from CIR
Wheat germamide DEA 1 safe in the present practicesof use and concentration
when formulated to be non-irritating and when the levelsof free DEA do not exceed
those considered safe int theCIR safety assessment ofDEA and its salts; shouldnot be used in cosmetic
products in which N-nitrosocompounds may be formed
IJT 32(S1):36-58,2013
Wheat germamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
IJT 31(S1):77-111,2012
Wheat germamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which
may be based on aquantitative risk assessment
Final report 06/2014available from CIR
Wheat Germ Glycerides 1 up to 25% JEPT 4(4):5- 17,1980 confirmed
06/01 IJT22(S1):1-35, 2003
Wheat Germ Oil PEG-40 Butyloctanol Esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Wheat Germ Oil PEG-8 Esters 1 safe for use in cosmetics whenformulated to be non-irritating
IJT 33(S4):13-39,2014
Wild Yam (Dioscorea Villosa) Root Extract 1 up to 15% of max2% plant solids
IJT 23(S2):49-54,2004
Xanthan Gum 1 0.00001 to 6% Final report 09/12available from CIR
Xanthan Gum Crosspolymer 1 0.03 to 5% Final report 09/12available from CIR
Xanthan Hydroxypropyltrimonium chloride 1 not in current use* Final report 09/12available from CIR
Xylene Sulfonic Acid 1 not in current use* IJT 30(S3):270-283,2011
Xylobiose 1 Final report 03/2014available from CIR
Xylose 1 Final report 03/2014available from CIR
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Yeast amino acids 1 not in current use* IJT 33(S4):5-12,2014
Zea Mays (Corn) Cob Meal 1 up to 3% IJT 30 (S1): 17-39,2011
Zea Mays (Corn) Cob Powder 1 up to 10% IJT 30 (S1): 17-39,2011
Zea Mays (Corn) Fruit 1 not in current use* IJT 30 (S1): 17-39,2011
Zea Mays (Corn) Germ Extract 1 concentration not reported* IJT 30 (S1): 17-39,2011
Zea Mays (Corn) Germ Oil 1 0.2 to 25% Final amended report03/11 available
from CIR; IJT 30(S1): 17-39, 2011
(original)Zea Mays (Corn) Gluten Protein 1 0.03 to 0.1% IJT 30 (S1): 17-39,
2011Zea Mays (Corn) Kernel Extract 1 up to 0.5% IJT 30 (S1): 17-39,
2011Zea Mays (Corn) Kernel Meal 1 up to 3% Final amended report
03/11 availablefrom CIR; IJT 30(S1): 17-39, 2011
(original)Zea Mays (Corn) Oil 1 up to 14% Final amended report
03/11 availablefrom CIR; IJT 30(S1): 17-39, 2011
(original)Zea Mays (Corn) Oil Unsaponifiables 1 concentration not reported* Final amended report
03/11 availablefrom CIR; IJT 30(S1): 17-39, 2011
(original)Zea Mays (Corn) Seed Flour 1 concentration not reported* IJT 30 (S1): 17-39,
2011Zea Mays (Corn) Silk Extract 1 up to 0.1% IJT 30 (S1): 17-39,
2011Zea Mays (Corn) Starch 1 up to 99% IJT 30 (S1): 17-39,
2011Zeolite 1 not in current use* IJT 22(S1):37- 102,
2003Zinc Acetate 1 concentration not reported* IJT 31(S1):112-136,
2012Zinc borosilicate 1 not in current use* IJT 32 (S3): 65-72,
2013Zinc citrate 1 0.05% in leave-on;
0.3 to 2% in rinse- offIJT 33 (S2): 16-46,
2014
Quick Reference TableReview
Conclusion****Explanation Journal Citation
Ingredient Name or Group Name S SQ I Z U UNS Use concentrationfor S conclusion
Concentration orother limitation on
use for SQ conclusion
Safety concern for Uor UNS conclusion
Zinc Coceth Sulfate 1 safe in the present practices ofuse and concentration when
formulated to be non-irritating
IJT29(S3) :151-161,2010
Zinc Coco-Sulfate 1 not in current use* IJT 29(S2): 115-132,2010
Zinc lauroyl aspartate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating
Final report 12/2013available for CIR
Zinc Myristate 1 up to 20% IJT 29(S3) :162-186,2010
Zinc Phenolsulfonate 1 up to 4% JACT 5(5):373-90, 1986 confirmed
06/04 IJT 25(S2),2006
Zinc Ricinoleate 1 up to 2% IJT 26(S3): 31-772007
Zinc Stearate 1 up to 51% JACT 1(2):143-77,1982 confirmed
11/01 IJT22(S1):1-35, 2003
Zirconium Silicate 1 not in current use * IJT 22(S1):37-102,2003
* Were the ingredient to be used in the future, the expectation is that it would be used at concentrations comparable to others in the group.** Safety as a hair dye ingredient was reaffirmed in 2004; but the Panel noted that the use of p-Phenylenediamine with henna (so-called dark henna) for temporary tattoos is unapproved by FDA — p-Phenylenediamine is a knownsensitizer, highly inappropriate for such use as evidenced by reports of severe adverse skin reactions to dark henna temporary tattoos.*** in addition, "red" panax ginseng root extract and "white" panax ginseng root extract are reported to be used, within the given concentration range, but they are not separately listed as cosmetic ingredients**** S - safe in the present practices of use and concentration SQ - safe for use in cosmetics, with qualifications I - the available data are insufficient to support safety Z - the available data are insufficient to support safety, but theingredient is not in current use U - the ingredient is unsafe for use in cosmetics UNS - ingredients for which the data are insufficient and their use in cosmetics is not supported Note: the number given is the number of ingredientsin the given category in that row