Quantifying Abnormal Muscle Tone Due to Neurological ... MyoSenseWeb… · neurological disorders...
Transcript of Quantifying Abnormal Muscle Tone Due to Neurological ... MyoSenseWeb… · neurological disorders...
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Quantifying Abnormal Muscle Tone Due to Neurological Impairment
Thursday March 20th, 2014 Starts at 12:00 PM EST
Presented by Elizabeth Brokaw, PhD
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Kinesia HomeViewTM Kinesia ProViewTM
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MyoSense
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• Impact of Neurological Impairment
– Abnormal Muscle Tone
• MyoSense
– Development
– Bench Testing
– Clinical Evaluation
Outline
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• High incidence of neurological disorders
– Abnormal muscle tone
– Reduced independence
Individuals With Neurological Impairment
Stroke 795,000
Center for Disease Control; Jan 2006 Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations, and Deaths, 2002-2006
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• Resistance force to passive movement
• Abnormal muscle tone presents in many different forms.
– Rigidity
– Dystonia
– Spasticity
– Hypertonia
Abnormal Muscle Tone
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Rigidity
• Parkinson’s Disease
– Stiffness or heaviness
• Lead pipe
• Cog wheel
Rigidity
UCD Medicine https://www.youtube.com/watch?v=sJqKvajUC3k
Lead Pipe
Speed/Position
Forc
e
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Cog wheel
Position
Forc
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• Cerebral Palsy
– Rigid/Posturing
– Unintentional movement
Dystonia
http://www.localmatters.co.nz/
http://www.ndta.org/clinicians-corner.php?id=4
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Rigid Dystonia
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Spasticity
• Stroke and Traumatic Brain Injury
– Speed based
– Catch
Spasticity
www.strokeassociation.org
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Hypertonia
• Stroke and Traumatic Brain Injury
– Range of motion
Hypertonia
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Treatments
• Various types of treatment
– Botox
– Baclofen
– Phenol injections
– Surgical intervention
– Deep brain stimulation
Treatments
http://jarrettwilsontbi.wordpress.com/ 2013/08/05/tbi-is-truly-stunning-botox-images/
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Tone Management
• Abnormal tone types respond differently
• Difficult to distinguish different types of tone
– Cerebral palsy
• Research limited by current clinical outcome measures
Issues with Abnormal Tone Management
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DBS Baclofen Dystonia
Dystonia Spasticity
Spasticity
? ?
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Clinical Scales
• Specific aspects of abnormal tone • Modified Ashworth, Tardieu (spasticity)
• Fahn Marsden Burke (dystonia)
• Low resolution
• Subjective interpretation
Clinical Scales
FMB Arm Evaluation 0 No dystonia present 1 Slight dystonia. Clinically insignificant 2 Mild. Obvious dystonia but not disabling 3 Moderate. Able to grasp, with some manual function 4 Severe. No useful grasp
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MyoSense Development MyoSense Development
• Quantitative assessment of abnormal tone
• Integrate with conventional practice
– Clinician worn
• Reduce patient burden
– Typical Assessment
• Speed
• Position
• Force
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Myosense
• Prototype Hardware
– Flexiforce FSR sensors and XBee
– GLNT Movement Sensor (bluetooth)
MyoSense
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• Information about orientation and speed
• Correlate with force data
MyoSense Data
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MyoSense Bench Testing
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Simulated Abnormal Elbow Tone
Threshold set at 45 deg/s
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Distinguishing Profiles
• Hypertonia Evaluation – Move the simulated
elbow at 5 deg/s
• Position bins and
average force
• Correlation to theoretical = 0.93
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Distinguishing Profiles
• Mod-Ashworth Evaluation – Move the simulated elbow
at 90 deg/s
• Speed bins and average
force
• Correlation to theoretical = 0.80
• High speed effects of
device mechanics – Belts and filtering
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• Issue – High speed mechanical effects
– Acceleration
– Change in direction
• Solution
– Track specific speeds
– Examine the change across speed
Comparing Different Abnormal Tone Profiles
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• Tracking specific speeds
– 5, 25, 45, 65, 85 deg/s
• At each 20s trial
– Average speed and average force
Comparing Different Abnormal Tone Profiles
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• Correlation of 0.99
• Distinguish Profiles and Changes in magnitude
Comparing Different Abnormal Tone Profiles
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• Successful pilot evaluation of MyoSense
• Clinical evaluation with individuals with spasticity, dystonia, and cerebral palsy
Bench Testing Conclusion
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MyoSense Clinical Evaluation
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Clinical Evaluation Protocol
• Subjects – 10 Pure dystonia – 10 Pure spasticity – 10 Mixed dystonia and spasticity (Cerebral Palsy) – 30 Age matched controls
• Clinician manipulates limb
– 5, 45, 90, 135, 180 – wrist, elbow, knee, ankle – Mod Ashworth and Fahn Marsden Burke
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Individual with Dystonia
Preliminary Results
FMB = 1 FMB = 0
Unimpaired Control
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Clinical Evaluation Goals
• Goal from Clinical Evaluation
– Differentiate types of abnormal muscle tone
– Examine correlation to clinical measures
• Commercialization
– Effects of spasticity and dystonia
– Effects of treatments
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Acknowledgements
• Dr. Erwin Montgomery
• Dr. Ilia Itin
• Alexandria Wyant
• Funding from NIH
National Institute of Neurological
Disorders and Stroke (1R43NS076052-01A1)
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GLNT Movement Sensor
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http://glneurotech.com/motion-sensor