QUADRO HV Wet Milling and Emulsifier

Quadro Engineering Corp.Liquids Division

Replace your old and antiquated Piston Homogenizers and Media Mills when milling API’s to the 10-15 micron range with the QUADRO HV

Wet Mill/ Emulsifier

Rotor speed 70 meters/second

Trotter Equipment (513) 321-5000 – Ohio, Kentucky, Indiana, West Virginia

In Line Wet Milling Technology

In Line Wet Milling

Technology


In-Line Emulsifier Technologies – HV Emulsifier

Low Pumping

Higher Shear

High Pumping

Lower Shear

Macro-Emulsions (1-5µm)

Homogenization

Modify Product Texture

Fine Particle Dispersion

ShearFX Pump Quadro Ytron® Z-Emulsifier HV-Emulsifier

Submicron Emulsions

Homogenization

Very Fine Dispersion

Cell Disruption

In-Line High Velocity Wet Mill & Emulsifier: HV Emulsifiers

Pharmaceutical:

HV Preconditioning = reduce nano-processing (i.e.<0.2µm) down to a single-pass

Closes gap between standard rotor/stator emulsifiers and Piston Homogenizers


In-Line Wet Milling Technologies – HV Wet Mill

Low Pumping

Higher Shear

High Pumping

Lower Shear

ShearFX Pump Quadro Ytron® Z-Emulsifier HV-Wet Mill

Wet Milling 5 to 20 µm

• Energy optimized high velocity (70m/s) rotor• Sanitary high speed double mech. seal • Inboard seal design eliminates product trap areas• Safety flow switch on seal flush piping• Switch integrated VFD improves seal life

• Enhanced rotor/stator increases shearing energy• Recirculation set up typical for API processing

In-Line High Velocity Wet Mill & Emulsifier: HV Wet Mill

Limited Wet Milling Applications


In-Line Emulsifier Technologies – HV Emulsifier

High Tolerance Designs

In-Line High Velocity Wet Mill and Emulsifier: HV Emulsifiers



Particle Size Distribution

0.1 1 10 100 1000

Particle Size (µm)

0

0.5

1

1.5

2

2.5

3

3.5

4

4.5

5

5.5

6

6.5

7

7.5

8

8.5

9

9.5

10

10.5

Volu

me (

%)

Brinzolamide - Z1 1 Pass, Thursday, August 20, 2009 1:42:43 PM

Traditional Rotor/Stator

d90 = 67 µm

avg = 36 µmd90 = 9.7 µm

avg = 4.9 µm

Test API Suspension8 wt% Crystalline API91-92 wt% Distilled Water<1 wt% Surfactant (Wetting Agent)

Infeed

After HV Rotor/Stator @ 70m/s

d90 = 405 µm

avg = 216 µm


An Evaluation of an Enhanced Wet Milling Technology for Further

API Particle Size Reduction – MERCK White Paper, AAPS 2011

Traditional Rotor/Stator (R/S) at 23 m/s vs. Quadro HV at 70 m/s


Ref. AAPS Poster : An Evaluation of an Enhanced Wet Milling Technology for Further API Particle Size ReductionMerck & Co. - Ivan Lee Jonathan Ostrosky Mark Walker Eric Sirota Luke Schenck




Traditional Rotor/Stator (R/S) at 23 m/s vs. Quadro HV at 70 m/s



500x500x





Traditional R/S at 23 m/s vs. Quadro HV at 70 m/s


500x





Conclusions

• Increased rotor tip speeds greatly broaden wet milling capabilities• Practical lower limit for mV achievable via wet milling may be 12-20um

• Potential for additional reduction with reduced rotor/stator clearance

• Potential for additional reduction by operating at flow rates above natural draw

• Particle aspect ratio a key to the extent of additional breakage attainable by increased tip speeds

• Low aspect ratio materials [blocky] see the most additional breakage by increasing tip speed from 23 to 70 m/s compared to high [rod] aspect ratio material (40-60% vs. ~ 0-20% additional breakage respectively)

• Appears that at elevated tip speeds, slurry concentration (and potentially particle/particle impacts) plays a less important role in breakage




HV0 Lab Scale= 1-5 kg/min

HV1 Pilot 75 kg/min

HV3 Production225 kg/min



Product Specifications

Standard Specifications HV-Emulsifier Product Line

Model # HV0 NEW HV1 HV3 HV5 Dev.

Oil/Water Droplet Size Reduction ≤ 1 Micron

Motor Driven Design Poly Chain Synchronous Belt Driven System

Std Wetted Contact Material 304 Stainless Steel (316/L Optional)

Wetted Material Surface Finish 150 Grit (~42 Ra or Better)

External Surface Finish Non-Specific Machined w/ B.B. Base

Shear Stage Design Course, Med, Fine or Progressive Tooling

Number of Shear Stages Single Stage w/ Std or Enhanced Shear Design

Standard Seal Design High Speed Sanitary Dble Mech w/Water Flush

Capable of CIP/SIP Yes

Shear Stage Diameter (in) 3.5 5.8 9.3 10.7

Shear Stage Diameter (mm) 90 148 237 273

Max Rotor Tip Speed (m/s) 70 70 70 70

Motor Size (Hp) 7.5 20-25 40-60 75-125

Spindle Speed (RPM) 15000 9000 5600 4900

Standard Electrics 220…575 Volt, 50/60 Hz, 3-Phase

Nominal Capacity (gpm) 0.3-2.5 5-25 30-75 70-125

Standard Flange Style Sanitary Tri-Clap Flange

Inlet Fitting Size (in) 1/2 2 3 4

Outlet Fitting Size (in) 1/2 1.5 2.5 3.0



Summary

• >55x the energy dissipation at a tip speed of 70m/s

• Droplet disruption up to ~16x more effective than trad. R/S

• Submicron to nano-size droplets are achievable (avg ~0.1-.4µm)

• HV-Emulsifier closes the gap between traditional R/S & HPH

• HV-Emulsifier defines new limits, extending R/S tech. into submicron size reduction


Quadro Engineering Corp.Liquids Division

For additional information:In Ohio, Kentucky, Indiana & West VirginiaPlease contact Trotter Equipment(513) 321-5000Email – click [email protected]

mailto:[email protected]?subject=QUADRO%20HV%20Wet%20Milling%20&%20Emulisifier

QUADRO HV Wet Milling and Emulsifier

Engineering

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