Quadrant-Cover Page · PGxOne™ Plus is a 62 gene pharmacogenomics (PGx) test that can provide...
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1 See full sample report at www.admerahealth.com/pgx PGxOne™ Plus is a 62 gene pharmacogenomics (PGx) test that can provide insight into how a patient will respond to certain drugs based on their DNA. Test results are delivered in an easy to read report with gene-drug interactions aligning with the FDA’s latest recommendations. In combination with RxVision™, Admera Health’s Clinical Decision Support System (CDSS), the PGxOne™ Plus test provides the most complete PGx assessment available for patient management solutions. Quadrant-Cover Page A snapshot of the Gene-Drug Interactions for the patient’s Current Medications and Medications of Interest Patient, Sample, and Physician Information
Transcript of Quadrant-Cover Page · PGxOne™ Plus is a 62 gene pharmacogenomics (PGx) test that can provide...
1See full sample report at www.admerahealth.com/pgx
PGxOne™ Plus is a 62 gene pharmacogenomics (PGx) test that can provide insight into how a patient will respond to certain drugs based on their DNA. Test results are delivered in an easy to read report with gene-drug interactions aligning with the FDA’s latest recommendations. In combination with RxVision™, Admera Health’s Clinical Decision Support System (CDSS), the PGxOne™ Plus test provides the most complete PGx assessment available for patient management solutions.
Quadrant-Cover Page
A snapshot of the Gene-Drug Interactions for the patient’s
Current Medications and Medications of Interest
Patient, Sample, and Physician Information
See full sample report at www.admerahealth.com/pgx 2
Admera Health, LLC126 Corporate Blvd · South Plainfield, NJ 07080
+1-908-222-0533 · [email protected]
Section 1: Current Medications and Medications of Interest
Report Sections
Current Medications and Medications of Interest
Gene-Drug Interaction Results
Drug Interactions
Comprehensive Drug List
FDA-aligned Gene-Drug Interaction Results
Genotype and Phenotype Results
Results for all 62 genes included
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Drug, Source, Gene, Patient Specific Genotype and Patient Impact
At a glance result
Therapeutic Area, Drug Class, and Mechanism of Action
See full sample report at www.admerahealth.com/pgx 3
Admera Health, LLC126 Corporate Blvd · South Plainfield, NJ 07080
+1-908-222-0533 · [email protected]
Applicable Drug Interactions
Drug Interactions Included
NO or LIMITED Pharmacogenomics Evidence
Severity warning depicted in an icon and an explanation
Documentation of the level of evidence supporting the interaction
Section includes the patient’s Current Medications or Medications of Interest
that have NO or LIMITED pharmacogenomics evidence and can be populated with as
many drugs as applicable
Drug-Drug Drug-Food Drug-Alcohol Drug-Laboratory
Drug interactions can result in adverse side effects, reduce the effectiveness or increase drug activity.
Food consumption can affect the activity of some drugs, altering efficacy.
Alcohol does interact with some medications and can lead to increased risk of illness, injury, or death.
Some laboratory test results can be misleading. Certain medications can falsely elevate a lab test, resulting in a false positive.
See full sample report at www.admerahealth.com/pgx 4
Admera Health, LLC126 Corporate Blvd · South Plainfield, NJ 07080
+1-908-222-0533 · [email protected]
Section 2: Comprehensive Drug ListCertain gene-drug
interactions have a dual recommendation, both a
primary impact statement and a secondary situational
dependent statement
Certain drug interactions can involve multiple genes that affect the
Patient Impact
Comprehensive expansion on the medical and pharmacogenomics clinical utility of the
gene-drug interaction
Section 3: Complete Genotype and Phenotype Results
List of all 62 Genes in the PGxOne™ Plus Test
Patient Specific Genotype Results for all 62 Genes
Corresponding Functional Phenotype Results for all 62 Genes
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II
III
III III
See full sample report at www.admerahealth.com/pgx 5
Admera Health, LLC126 Corporate Blvd · South Plainfield, NJ 07080
+1-908-222-0533 · [email protected]
Includes 62 GenesGene-drug interactions align with sources from the FDA and guidelines from the Clinical Pharmacogenomics Implementations Consortium (CPIC) and Association for Molecular Pathologists (AMP).
ABCB1 ATM CYP2B6 DPYD HLA-A KIF6 NUDT15 SLCO1B1
ABCC4 BCHE CYP2C19 DRD2 HLA-B LTC4S OPRM1 TNF
ABCG2 CACNA1S CYP2C8 ERCC1 HTR1A MC4R POLG TPMT
ACE CES1 CYP2C9 F2 HTR2A MTHFR PTGFR UGT1A1
ADD1 CFTR CYP2D6 F5 HTR2C MTRR PTGS1 UGT1A4
ADRB2 COMT CYP3A4 G6PD IFNL3 NAT2 RYR1 VKORC1
APOE CRHR1 CYP3A5 GNB3 Intergenic (CYP2C) NEDD4L SCN1A
ATIC CRHR2 CYP4F2 GSTP1 ITPA NQO1 SLC6A4
• ApoE
• CFTR
• CYP2D6
• CYP2C9/VKORC1
• CYP2C19
The following genes, given a specific genotype, have been associated with high risk of adverse drug reactions, treatment failure, and disease state. Please consult with the pharmacist if the patient is at risk with their current medication list. In addition, please keep in mind that a genetic counselor or a geneticist consult is recommended for the underlined genes when results indicate a potential disease state.
• DYPD
• F2
• F5
• G6PD
• HLA-A/*3101
• HLA-B/*1502 AND *5701
• MTHFR
• POLG
• RYR1/CACNA1S
• SLC01B1
• TPMT/NUDT15
• UGT1A1
6See full sample report at www.admerahealth.com/pgx
Gain digital access to all patients’ PGxOne™ Plus results even without an EMR integration
Easily navigate test results with dynamic searches, including by Medication, Therapeutic Area, and Drug Interactions
Securely and easily refer a patient’s report to another physician
Providing in-depth pharmacogenomics based patient management solutions. Available on desktop, Android, and iOS devices.
How to Login to RxVisionTM
Clinical Decision Support System for Providers
Visit Admera Health’s RxVisonTM at: https://rxvision.admerahealth.comhttps://rxvision.admerahealth.com
