Pycnogenol for Topical Skin Care

8/12/2019 Pycnogenol for Topical Skin Care

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Topical Skin Care

L O O K , F E E L A N D L I V E B E T T E R


2/5I Horphag Research-Geneva, SwitzerlandI Horphag Research Asia-Shanghai, ChinaI Natural Health Science-Hoboken NJ, USAI www.pycnogenol.comI HORPHAGI

Human skin absorbs Pycnogenol

ycnogenolwas tested for the ability to be absorbed

y uman s n Sar a et a , 2004 . A Pycnogenoo ut on was app e to a v a e uman s n patc

nd molecules penetrating the skin were identified.

Sma er const tuents suc as p eno c ac s were

ent a e a rea y 30 m n a ter app cat on. Many

onstituents, including catechin, showed the high-

st concentrat on a ter 4 ours. Many const tuents o

ycnogeno were measura e n s gn cant quant -

ies even 12 hours after application.

Pycnogenol binds and protects collagen

and elastin

ycnogenolhas a high affinity to proteins rich in the

m no ac y roxy -pro ne. T ese are pre om nant y

e matr x prote ns n t e s n, co agen an e ast n.

hen Pycnogenolis added to collagen or elastin, a

g amount rema ns t g t y oun . In consequence,ycnogeno a so t g t y n s to t e s n. To ot er

prote ns suc as a um ns Pycnogeno as tte a -

n ty Gr mm et a ., 2004 .

Furt er exper ments s owe t at Pycnogeno as

we as ts meta o tes, eve opng a ter ora con-

sumption in humans, protects collagen and elastin

rom enzymat c egra at on. T ese enzymes, ma-

tr x meta oprote nases MMPs , n uence t e equ -

ycnogenol is widely used in topical and oral applications for various dermatological indications. A unique

om ination o p armaco ogica unctions o Pycnogeno provi es an unmatc e variety o ea t en-

efits for skin health.

Pycnogenol

Human skin absorbs Pycnogenol

Pycnogenol in Topical Skin Care

unspecific protein collagen

elastin skin

0 10 20 40 5030

Pycnogenolprotein binding

2.1%

33.9%

37.9%

41%

0 20 40 8060

Pycnogenol[g/ml]

80%

60%

40%

20%

0%

Collagenprotection

Pycnogenolinhibits collagenase



r um etween co agen egra at on an renewa .

he inhibitory concentrations (IC50) of Pycnogenol

eta o tes were ower t an t at o a nown MMP-

n tor Captopr . As an examp e, n t on o co -

agen degradation by collagenase in presence of

ycnogeno s s own e ow.

Pycnogenol accelerates wound healing

and lowers scar formation

n a p armaco og ca stu y t e a ty o s n to

eal wounds was investigated [Blazs et al., 2003].

oun s were n cte y eat treatment o owey top ca app cat on o Pycnogeno ge once a ay

ntil healing. In absence of treatment the healing pro-

ess too 15.3 ays an app cat on o ge w t out

ycnogeno a no e ect on t e ea ng t me. Ge

with 1% Pycnogenol was found to accelerate the

ea ng process y 1.6 ays as compare to ge w t -

ut Pycnogeno Pycnogeno was oun to ose-

dependently shorten the period required for wound

ea ng. Furt ermore, scar s ze was owere w t n-

reas ng Pycnogeno concentrat on.

n two clinical trials topically applied Pycnogenol

was s own to mprove ea ng o u cers n n v u-

s w t venous sor ers or a etes Be caro et a .,

2005 & 2006]. Application of Pycnogenol powder

rect y onto u cers n 30 a et c pat ents a oweomp ete ea ng n 84% o pat ents, w ereas t e

ontro group rece v ng stan ar treatment on y a

61% with completely healed ulcers.

Pycnogenol is a potent antioxidant

Pycnogenol was demonstrated to be a very potent

nt ox ant w t t e a ty to neutra ze every natura -

y occurr ng oxygen ra ca spec es Ro ewa 2002 .

Pycnogenol can recycle oxidized (spent) vitamin C to

restore ts act v ty. T s supports t e ava a ty o v -

tam n C as co- actor or t e enzymat c act v ty o pro-

lyl hydroxylase, which synthesizes functional collagen

n e ast n. For more eta s on t e ant ox ant actv-ty o Pycnogeno p ease re er to PYCNOGENOL

SUPER ANTIOXIDANT.

Pycnogenol helps prevent UV damage and

photo-ageing

Exposure o t e s n to UV- g t generates react ve

xygen ra ca s an tr ggers pro- n ammatory pro-

esses which may cause sunburn. Pycnogenolwas

s own n prec n ca stu es to e ect ve y counteract

sun urns S me at a ., 2004 .

T e s n t c ness was eva uate a ter exposure o

t e s n to UV- g t o r t ree consecut ve ays, w c

serves as measure for the skin sunburn reaction. As

ompare to ase ne, t e UV exposure a most ou-

e t e s n t c ness, re ectng a s gn cant react on

f the skin to the UV radiation. Application of lotions

onta n ng Pycnogeno to t e s n mme ate y a ter

Topical Skin Care

Control (untreated) Control (gel only)

Pycnogenol1% Pycnogenol2%

Pycnogenol5%

0 5 10 15 days

15.3

15.4

13.8

12.6

12.1

Pycnogenolaccelerates wound healing

no UV Control (gel only)

Pycnogenol

0.025%Pycnogenol0.2%Pycnogenol0.1%Pycnogenol

0.05%

0 0.5 1.0 2.0 mm1.5

1.74

0.90

1.70

1.51

1.49

1.43

Pycnogenol

protects from UV-induced edema



ac UV-exposure ose- epen ent y re uce e ema.

concentration as low as 0.05% Pycnogenol signifi-

ant y n te t e n ammatory sun urn react on.

ycnogeno was app e to s n a ter UV-exposure

because the procyanidins in Pycnogenol absorb UV-

g t. App cat on to t e s n su sequent to UV-expo-

ures ensures t at exc us ve y t e ant - n ammatory

properties of Pycnogenol are act ve.

ycnogeno was a so s own to potent y counteract

e system c mmuno-suppress ve e ects o UV-ra -

tion. Application of 0.1% Pycnogenollotion to ex-

pose s n post rra at on restore t e UV-a ecte

mmune response eva uate as contact ypersens -

ivity to chemical irritants) to 87% of non-irradiated

eve s S me et a ., 2004 .

ycnogenol

was demonstrated to protect from UV-a at on n uce carc nogenes s S me et a ., 2004 .

n a sence o Pycnogeno treatment 0% m ce

hronically exposed to UV began to develop benign

pap omas a ter 11 wee s w c t erea ter pro-

gresse towar s more ma gnant states. Pycnogeno

otion applied after each UV-exposure prolonged

e onset o tumors, t s e ect reac e s gn cant y

w en 0.2% Pycnogeno was app e . Some m ce

reated with 0.2% Pycnogenol never developed a

umor ur ng t s exper ment. T ese n ngs suggests gn cant p oto-protect ve e ect o Pycnogeno

Pycnogenol has broad anti-microbial

activityPycnogeno exerts ant -mcro a act v ty aga nst a

roa range o m cro-organsms: gram pos t ve an

negative bacteria, as well as yeast [Torras et al, 2005).

T e m n mum n tory ose range rom 20 g/m ,

suc as or Stap ococcus aureus, to 250 g/m as

in the case of Campylobacter. The MID for Candida

cans was s own to e 30 g/m . Pycnogeno

oes not ave acter oc a act v ty. Upon ut on

f Pycnogenol concentration below MID, microbial

growt s w e restore . Formu at ons earng ateast 0.025% Pycnogeno w possess ant -m cro a

ctivity towards both gram positive and negative bac-

ter a as we as Can a a cans.

Pycnogenol is effective for acne treat-

ment

Pycnogeno as een c n ca y teste n 40 women

suffering from adult acne. A 0.5% Pycnogenollotion

was app e tw ce a ay a ter was ng t e ace. T e

symptom sever ty was nvest gate at ase ne an a -ter 1 month treatment using an established symptom

sever ty gra ng stan ar Se et a ., 2006 .

The results showed that the majority of women ex-

per ence an mprovement o t e r acne. One n our

women exper ence any e ect o t e treatment.

75% of the women found an improvement and 5%

a t e r acne ramat ca y mprove .

Topical Skin Care

Control (unt reated) Pycnogenol0.05% Pycnogenol0.2%

5

4

3

2

1

0

Skin tumorsper mouse

0 10 15 25 30 35 weeks20

Prevention of chronic UV-induced tumors

25%

20%

5%

50%

no change mild improvement

improvement str ong i mprovement

Pycnogenolimproves acne



ycnogenolwas suggested to improve acne as a result of its anti-inflammatory activity, its anti-microbial activity as

we as t e mprove woun ea ng propert es. T s stu y suggests t at Pycnogeno may e ene c a n a var ety

s n con t ons nvo v ng n ammatory an n ect ous components.

ycnogeno s most e ectve or ea t y s n w en t s app e top ca y as we as ta en as supp ement. Eac e-

ivery form has unique advantages. Both delivery forms in combination provide optimal supply with nutrients from

w t n an warrant g est e cacy part cu ar y or p oto-protect on an mprove s n e ast c ty. P ease c ec or

ore eta s: PYCNOGENOL .

ReferencesBelcaro G et al. Venous ulcers: microcirculatory improvement and faster healing with local use of Pycnogenol . Angiology 56:

699-705, 2005.

elcaro G et al. Diabetic ulcers: Microcirculatory improvement and faster healing with Pycnogenol . Clinical and Applied Throm-

osis/Hemostasis 12: 318-323, 2006.

azs G et a . Pycnogeno acce erates woun ea ing an re uces scar ormation. P ytot er Res 18: 579-581, 2004.

Grimm T et a . ntioxi ant activity an in i ition o matrix-meta oproteinases y meta o ites o maritime pine ar extract

Pycnogeno . Free Ra Bio Me 36: 811-822, 2004.

ari a i V et a . In vitro percutaneous a sorption o pine ar extract Pycnogeno in uman s in. J Cutan Ocu Toxico 23 3 :

- , .

o ewa P. A review of the French maritime pine bark extract (Pycnogenol ), a herbal medication with a diverse pharmacol-

gy. Int J Cin P armaco T er 40 4 : 158-168, 2002.

eki M. Treatment of adult acne with Pycnogenol. Manuscript in preparation. 2006.

ime S et a . Protection rom in ammation, immunosuppression an carcinogenesis in uce y UV ra iation in mice y topica

ycnogenol Photochem & Photobiol 79:193-198, 2004.

orras MA et a . Antimicro ia activity o Pycnogeno P ytot er Res 19: 647-648, 2005.

Topical Skin Care

Pycnogeno represents a very potent cosmetic ingredient which offers a broad range of clinically substantiated

ea t ene ts:

Ant ox ant potency

Improved skin health and collagen renewal

Anti-microbial activity

Ant - n ammatory act v ty

Ant -p otoag ng an sun-protect on

Pycnogenol for Topical Skin Care

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