PUBLICATIONS, lectures / Pirjo Nuutila · CURRICULUM VITAE – Nuutila Name Pirjo Riitta Nuutila...
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Pirjo Nuutila 1 CURRICULUM VITAE – Nuutila Name Pirjo Riitta Nuutila Nationality: Finnish Date and place of birth: June 19, 1959, Mouhijärvi, Finland Address office Turku PET Centre, University of Turku, PL 52, 20520 Telephone +358 23131868 (office), +358 50 5366534 (mobile), Fax +358 2 2318191 E-mail [email protected] CURRENT POSITIONS Professor of Metabolic Research (Turku PET Centre), University of Turku (1999- Professor of Medicine (Department of Medicine), University of Turku (2005-2010, off duty) Chief physician of sector of endocrinology and diabetes, Turku University Hospital, Turku, (2005- Vice-rector (University of Turku) 1.1..2010-31.7.2012 EDUCATION AND ACADEMIC DEGREES At University of Turku: Licentiate of Medicine (M.D.) 1984; Doctor of Medical Sciences (Ph.D.) 1992; Specialist Degree in Internal Medicine 1992, Diploma in Health Admistration2007 At University of Helsinki: Specialist Degree in Endocrinology 1996, Special Degree in Diabetology1996 PREVIOUS PROFESSIONAL APPOINTMENTS Physician (1986-1994, 1996-8) Depart. of Medicine, University Central Hospital of Turku Assistant Physician, Clinical Endocrinology, Univ Central Hospital of Helsinki, 1994-6 Lecturer, n Medicine, University of Turku, experimental 1994-1999, clinical 1999-2005 Junior Researcher, Academy of Finland, 1993-1994, 1997-1999 Professor of metabolic research, Turku PET Centre, University of Turku 1998- Professor of internal medicine , Department of Medicine, University of Turku, 1.1.2005- Chief physician of sector of endocrinology, Departm. of Medicine, Univ Hospital of Turku, 2001- RESEARCH INTEREST Clinical and experimental metabolic and endocrinological research, particularly diabetes, insulin resistance and risk factors for coronary artery disease studied using positron emission tomography (PET). OFFICIAL DUTIES AND ADMINISTRATIVE EXPERIENCE University of Turku : Turku Graduate School of Clinical Sciences member 2001-, director 2007- The National Clinical Research School, board member 2002-; Turku Clinical Research Center, board member 2007-; Turku Collegium for Science and Medicine, executive board member 2008 - PET Centre Vice director and member of executive broad 2000, 2002, 2004, 2007, 2009 Coordinator and PI of Marie Curie training site 2000-2005; Vice-Director, CoE of Molecular Imaging of Cardiovascular and Metabolic Disorders 2008- Southwest Finland Hospital District: Physician in charge 2001-2005, chief physician 2005- (sector of endocrinology and diabetes), Department of Medicine, University Hospital of Turku Foundations: scientific boards : Turku University Foundation, (2006 –), Finnish Diabetes Foundation (2006- 2008, chair 2008), Women in science in Finland, reviewer, O’Loreal ( 2006- ) PUBLICATIONS A list of publications consists of 211 original publications and 10 manuscripts in peer reviewed journals, and several reviews in international journals, in domestic peer-reviewed journals, other articles or letters in English, and approx. 300 congress abstracts. Citations (ISI) >4000. SCIENTIFIC PORTFOLIO Ongoing scientific collaboration: National:
Transcript of PUBLICATIONS, lectures / Pirjo Nuutila · CURRICULUM VITAE – Nuutila Name Pirjo Riitta Nuutila...
Pirjo Nuutila 1
CURRICULUM VITAE – Nuutila
Name Pirjo Riitta Nuutila Nationality: Finnish
Date and place of birth: June 19, 1959, Mouhijärvi, Finland
Address office Turku PET Centre, University of Turku, PL 52, 20520
Telephone +358 23131868 (office), +358 50 5366534 (mobile),
Fax +358 2 2318191
E-mail [email protected]
CURRENT POSITIONS
Professor of Metabolic Research (Turku PET Centre), University of Turku (1999-
Professor of Medicine (Department of Medicine), University of Turku (2005-2010, off duty)
Chief physician of sector of endocrinology and diabetes, Turku University Hospital, Turku, (2005-
Vice-rector (University of Turku) 1.1..2010-31.7.2012
EDUCATION AND ACADEMIC DEGREES
At University of Turku: Licentiate of Medicine (M.D.) 1984; Doctor of Medical Sciences (Ph.D.) 1992;
Specialist Degree in Internal Medicine 1992, Diploma in Health Admistration2007
At University of Helsinki: Specialist Degree in Endocrinology 1996, Special Degree in Diabetology1996
PREVIOUS PROFESSIONAL APPOINTMENTS
Physician (1986-1994, 1996-8) Depart. of Medicine, University Central Hospital of Turku
Assistant Physician, Clinical Endocrinology, Univ Central Hospital of Helsinki, 1994-6
Lecturer, n Medicine, University of Turku, experimental 1994-1999, clinical 1999-2005
Junior Researcher, Academy of Finland, 1993-1994, 1997-1999
Professor of metabolic research, Turku PET Centre, University of Turku 1998-
Professor of internal medicine , Department of Medicine, University of Turku, 1.1.2005-
Chief physician of sector of endocrinology, Departm. of Medicine, Univ Hospital of Turku, 2001-
RESEARCH INTEREST
Clinical and experimental metabolic and endocrinological research, particularly diabetes, insulin
resistance and risk factors for coronary artery disease studied using positron emission tomography
(PET).
OFFICIAL DUTIES AND ADMINISTRATIVE EXPERIENCE
University of Turku : Turku Graduate School of Clinical Sciences member 2001-, director 2007-
The National Clinical Research School, board member 2002-; Turku Clinical Research Center, board
member 2007-; Turku Collegium for Science and Medicine, executive board member 2008 -
PET Centre Vice director and member of executive broad 2000, 2002, 2004, 2007, 2009
Coordinator and PI of Marie Curie training site 2000-2005; Vice-Director, CoE of Molecular Imaging of
Cardiovascular and Metabolic Disorders 2008-
Southwest Finland Hospital District: Physician in charge 2001-2005, chief physician 2005- (sector of
endocrinology and diabetes), Department of Medicine, University Hospital of Turku
Foundations: scientific boards : Turku University Foundation, (2006 –), Finnish Diabetes Foundation (2006-
2008, chair 2008), Women in science in Finland, reviewer, O’Loreal ( 2006- )
PUBLICATIONS
A list of publications consists of 211 original publications and 10 manuscripts in peer reviewed journals, and
several reviews in international journals, in domestic peer-reviewed journals, other articles or letters in
English, and approx. 300 congress abstracts. Citations (ISI) >4000.
SCIENTIFIC PORTFOLIO
Ongoing scientific collaboration: National:
Pirjo Nuutila 2
Local: Prof. Juhani Knuuti (PET, University of Turku), prof. Jorma Viikari (Depart. of Medicine, Univ of Turku),
prof. Tapani Rönnemaa (Depart. of Medicine, Univ. of Turku), prof. Olli Raitakari (Dept.of Clin physiology,
PET), prof. Heikki Minn (Depart.of Oncology),
Other universities in Finland: prof. Markku Laakso , docent Jussi Pihlajamäki, prof. Seppo Ylä-Herttuala
(Kuopio), prof. Matti Välimäki, docent Camilla Schalin-Jäntti, prof. Hannele Yki-Järvinen (Helsinki), prof. Timo
Otonkoski (Helsinki), prof. Kari Alitalo (Helsinki), prof. Terho Lehtimäki (Tampere)
International:
prof. Ele Ferrannini and docent Patricia Iozzo (Turku/Pisa, Italy), prof. Keith Frayn, (Oxford, UK), prof Sven
Enerbäck (Gothenburg, Sweden) , Prof Martin Gotthard, Nimegen, NL, prof Decio Eizirik, Brussel, B,
Research awards and major grants : Awards: Scandinavian Society for the Study of Diabetes Young Investigator Award 1995
Helena Rubinstein Awards for Women, in Science with the support of Unesco 1998
Kliininen silmä –award, University of Turku, 2005
Grants for metabolic and diabetes research
EVO (Turku University Central Hospital) 400 040 € (1997-2010)
Academy of Finland 50 000 € (1997-2000), 103 000 € (2004-2006), 100 000€/y CoE support (2008-2013)
Novo Nordisk Fonden 150 000 € (1991-2008), Ahokas Foundation 13 000 € (1994), Diabetes Research
Foundation 40 000 € (1994-2000), Finnish Foundation of Cardiovascular Research 15 000 € (1995, 1996),
EU, Marie CurieTraining site150 000 € (2000-2004), EU FP6: Hepadip study, 180 000€ (2005-2010), EU
FP7: Betaimage 650 000€ (2008-2011), EU IMI: SUMMIT 250 000€ (2009-2011)
Research agreements during 1995-2009 (total 1.6 milj €)
Supervisor of 22 published PhD theses related to diabetes and metabolic research using PET;
Maria Raitakari (1996): Maija Mäki (1998): Hanna Laine (1998): Olli-Pekka Pitkänen (1998) Anne Kinnala
(1999) Teemu Takala (1999) ,Pauliina Peltoniemi (2001Kari Kalliokoski (2001) Jan Sundell (2002),Kirsi
Virtanen, (2003). ,Jukka Kemppainen (2003) , Kira Stolen. (2003) , Tuula Janatuinen.. (2003), Kirsti Hällsten.
(2004), Patricia Iozzo (2004), Riikka Lautamäki (2006), Jarna Hannukainen (2006), Riikka Kalliokoski (2006),
Alexandru Naum (2007), Ronald Borra (2009), Antti Viljanen (2009) Saila Kauhanen (2009)
Supervising 8 PhD students (in collaborative supervision with other established supervisors) ; Markus
Lindroos (2009, December) MELAS, in preparation.; Markku Vänttinen, (2009, November) PPAR gene
polymorphism and insulin sensitivity, Markku Asola, MD, Nina Koivuviita, MD, Anna Karmi, Marco Bucci,
Heidi Immonen, Janne Orava
Supervisor of 8 undergraduate students in years 1996-2009, Department of Medicine ( “syventävät opinnot”)
and 2 Master Works (PET Centre).
Co-ordinator of Marie Curie Training Site QKGA-1999-51330 (PET in cardiac and metabolic research) at
Turku PET Centre 2000-2005:Eight MC fellows from EU or associate countries worked at the centre, 3 out of
them completed their PhD in Turku
Invited teaching activity in scientific congresses, meetings and courses
Courses: since 1996
Opponent for 4 doctoral dissertations: Reviewer of 6 theses:
Reviewer of 3 docent applications:
Reviewer for journals: NEJM 1996-, Am J Physiol 1998-, Diabetologia 2001-, Diabetes 2002-, Obesity 2006-,
Member of Editorial board : J Nucl Medine 2004 -
Acting as a reviewer for grant applications: Cultural Foundation of Western Finland (2001), National Clinical
Research School (2002-) , FWF der Wissenschaftsfonds, Wien, Austria (2003), Wellcome Trust, UK (2006,
2008), Finnish Diabetes Foundation (2006-2008, chair 2008), Turku University Foundation, (2006 –), Women
in science in Finland, O’Loreal ( 2006- )
Pirjo Nuutila 3
Turku, 26th April, 2010 Pirjo Nuutila
Pirjo Nuutila 4
Publications:
2010: Heinonen Ilkka; Kemppainen Jukka; Kaskinoro Kimmo; Peltonen Juha E; Borra Ronald;
Lindroos Markus M; Oikonen Vesa; Nuutila Pirjo; Knuuti Juhani; Hellsten Ylva; Boushel Robert;
Kalliokoski Kari K Comparison of exogenous adenosine and voluntary exercise on human skeletal muscle
perfusion and perfusion heterogeneity. Journal of applied physiology (Bethesda, Md. : 1985) 2010;108(2):378-86.
2010: Hannukainen Jarna C; Kalliokoski Kari K; Borra Ronald J M; Viljanen Antti P M; Janatuinen Tuula; Kujala Urho M; Kaprio Jaakko; Heinonen Olli J; Viljanen Tapio; Haaparanta Merja; Iozzo
Patricia; Parkkola Riitta; Nuutila Pirjo Higher free fatty acid uptake in visceral than in abdominal subcutaneous fat tissue in
men.
Obesity (Silver Spring, Md.) 2010;18(2):261-5.
2009: Minn Heikki; Kauhanen Saila; Seppänen Marko; Nuutila Pirjo
18F-FDOPA: a multiple-target molecule. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(12):1915-8.
2009: Lindroos Markus M; Borra Ronald J; Parkkola Riitta; Virtanen Sami M; Lepomäki Virva; Bucci
Marco; Virta Jere R; Rinne Juha O; Nuutila Pirjo; Majamaa Kari
Cerebral oxygen and glucose metabolism in patients with mitochondrial m.3243A>G mutation.
Brain : a journal of neurology 2009;132(Pt 12):3274-84.
2009: Kauhanen Saila P; Komar Gaber; Seppänen Marko P; Dean Kirsti I; Minn Heikki R; Kajander
Sami A; Rinta-Kiikka Irina; Alanen Kalle; Borra Ronald J; Puolakkainen Pauli A; Nuutila Pirjo; Ovaska Jari T
A prospective diagnostic accuracy study of 18F-fluorodeoxyglucose positron emission tomography/computed tomography, multidetector row computed tomography, and
magnetic resonance imaging in primary diagnosis and staging of pancreatic cancer.
Annals of surgery 2009;250(6):957-63.
2009: Iozzo Patricia; Lautamaki Riikka; Borra Ronald; Lehto Hanna-Riikka; Bucci Marco; Viljanen
Antti; Parkka Jussi; Lepomaki Virva; Maggio Romina; Parkkola Riitta; Knuuti Juhani; Nuutila Pirjo Contribution of glucose tolerance and gender to cardiac adiposity.
The Journal of clinical endocrinology and metabolism 2009;94(11):4472-82.
2009: Salo Tiina Marjatta; Sundell Jan; Knuuti Juhani; Kemppainen Jukka; Stolen Kira; Nuutila Pirjo;
Mäkikallio Timo H; Huikuri Heikki V; Airaksinen K E Juhani Fractal scaling properties of heart rate dynamics and myocardial efficiency in dilated
cardiomyopathy. Clinical research in cardiology : official journal of the German Cardiac Society 2009;98(11):725-30.
2009: Komar Gaber; Kauhanen Saila; Liukko Kaisa; Seppänen Marko; Kajander Sami; Ovaska Jari; Nuutila Pirjo; Minn Heikki
Decreased blood flow with increased metabolic activity: a novel sign of pancreatic tumor aggressiveness.
Clinical cancer research : an official journal of the American Association for Cancer
Research 2009;15(17):5511-7.
2009: Koivuviita Niina; Tertti Risto; Järvisalo Mikko; Pietilä Mikko; Hannukainen Jarna; Sundell Jan;
Nuutila Pirjo; Knuuti Juhani; Metsärinne Kaj Increased basal myocardial perfusion in patients with chronic kidney disease without
symptomatic coronary artery disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant
Association - European Renal Association 2009;24(9):2773-9.
2009: Kiss Jan; Naum Alexandru; Kudomi Nobuyuki; Knuuti Juhani; Iozzo Patricia; Savunen Timo;
Nuutila Pirjo
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Non-invasive diagnosis of acute mesenteric ischaemia using PET.
European journal of nuclear medicine and molecular imaging 2009;36(8):1338-45.
2009: Viljanen Antti P M; Karmi Anna; Borra Ronald; Pärkkä Jussi P; Lepomäki Virva; Parkkola Riitta; Lautamäki Riikka; Järvisalo Mikko; Taittonen Markku; Rönnemaa Tapani; Iozzo Patricia; Knuuti
Juhani; Nuutila Pirjo; Raitakari Olli T
Effect of caloric restriction on myocardial fatty acid uptake, left ventricular mass, and cardiac work in obese adults.
The American journal of cardiology 2009;103(12):1721-6.
2009: Virtanen Kirsi A; Lidell Martin E; Orava Janne; Heglind Mikael; Westergren Rickard; Niemi
Tarja; Taittonen Markku; Laine Jukka; Savisto Nina-Johanna; Enerbäck Sven; Nuutila Pirjo Functional brown adipose tissue in healthy adults.
The New England journal of medicine 2009;360(15):1518-25.
2009: Honka Miikka-Juhani; Vänttinen Markku; Iozzo Patricia; Virtanen Kirsi A; Lautamäki Riikka;
Hällsten Kirsti; Borra Ronald J H; Takala Teemu; Viljanen Antti P M; Kemppainen Jukka; Pihlajamäki Jussi; Knuuti Juhani; Nuutila Pirjo; Laakso Markku
The Pro12Ala polymorphism of the PPARgamma2 gene is associated with hepatic glucose
uptake during hyperinsulinemia in subjects with type 2 diabetes mellitus. Metabolism: clinical and experimental 2009;58(4):541-6.
2009: Kudomi Nobuyuki; Koivuviita Niina; Liukko Kaisa E; Oikonen Vesa J; Tolvanen Tuula; Iida
Hidehiro; Tertti Risto; Metsärinne Kaj; Iozzo Patricia; Nuutila Pirjo
Parametric renal blood flow imaging using [15O]H2O and PET. European journal of nuclear medicine and molecular imaging 2009;36(4):683-91.
2009: Kauhanen Saila; Seppänen Marko; Ovaska Jari; Minn Heikki; Bergman Jörgen; Korsoff Pirkko; Salmela Pasi; Saltevo Juha; Sane Timo; Välimäki Matti; Nuutila Pirjo
The clinical value of [18F]fluoro-dihydroxyphenylalanine positron emission tomography in primary diagnosis, staging, and restaging of neuroendocrine tumors.
Endocrine-related cancer 2009;16(1):255-65.
2009: Lindroos Markus M; Majamaa Kari; Tura Andrea; Mari Andrea; Kalliokoski Kari K; Taittonen
Markku T; Iozzo Patricia; Nuutila Pirjo m.3243A>G mutation in mitochondrial DNA leads to decreased insulin sensitivity in
skeletal muscle and to progressive beta-cell dysfunction.
Diabetes 2009;58(3):543-9.
2009: Viljanen Antti P M; Iozzo Patricia; Borra Ronald; Kankaanpää Mikko; Karmi Anna; Lautamäki
Riikka; Järvisalo Mikko; Parkkola Riitta; Rönnemaa Tapani; Guiducci Letizia; Lehtimäki Terho; Raitakari Olli T; Mari Andrea; Nuutila Pirjo
Effect of weight loss on liver free fatty acid uptake and hepatic insulin resistance. The Journal of clinical endocrinology and metabolism 2009;94(1):50-5.
2009: Viljanen Antti P M; Lautamäki Riikka; Järvisalo Mikko; Parkkola Riitta; Huupponen Risto; Lehtimäki Terho; Rönnemaa Tapani; Raitakari Olli T; Iozzo Patricia; Nuutila Pirjo
Effects of weight loss on visceral and abdominal subcutaneous adipose tissue blood-flow and insulin-mediated glucose uptake in healthy obese subjects.
Annals of medicine 2009;41(2):152-60.
2008: Kauhanen Saila; Seppänen Marko; Nuutila Pirjo
Premedication with carbidopa masks positive finding of insulinoma and beta-cell hyperplasia in [(18)F]-dihydroxy-phenyl-alanine positron emission tomography.
Journal of clinical oncology : official journal of the American Society of Clinical
Oncology 2008;26(32):5307-8; author reply 5308-9.
2008: Heinonen Ilkka; Nesterov Sergey V; Liukko Kaisa; Kemppainen Jukka; Någren Kjell; Luotolahti
Matti; Virsu Pauliina; Oikonen Vesa; Nuutila Pirjo; Kujala Urho M; Kainulainen Heikki; Boushel Robert; Knuuti Juhani; Kalliokoski Kari K
Myocardial blood flow and adenosine A2A receptor density in endurance athletes and
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untrained men.
The Journal of physiology 2008;586(Pt 21):5193-202.
2008: Borra Ronald; Lautamäki Riika; Parkkola Riita; Komu Markku; Sijens Paul E; Hällsten Kirsti; Bergman Jörgen; Iozzo Patricia; Nuutila Pirjo
Inverse association between liver fat content and hepatic glucose uptake in patients with
type 2 diabetes mellitus. Metabolism: clinical and experimental 2008;57(10):1445-51.
2008: Kudomi N; Slimani L; Järvisalo M J; Kiss J; Lautamäki R; Naum G A; Savunen T; Knuuti J; Iida H; Nuutila P; Iozzo P
Non-invasive estimation of hepatic blood perfusion from H2 15O PET images using tissue-derived arterial and portal input functions.
European journal of nuclear medicine and molecular imaging 2008;35(10):1899-911.
2008: Tuunanen Helena; Engblom Erik; Naum Alexandru; Någren Kjell; Scheinin Mika; Hesse Birger;
Juhani Airaksinen K E; Nuutila Pirjo; Iozzo Patricia; Ukkonen Heikki; Opie Lionel H; Knuuti Juhani Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic
dilated cardiomyopathy.
Circulation 2008;118(12):1250-8.
2008: Rigazio Sara; Lehto Hanna-Riikka; Tuunanen Helena; Någren Kjell; Kankaanpaa Mikko; Simi
Claudia; Borra Ronald; Naum Alexandru G; Parkkola Riitta; Knuuti Juhani; Nuutila Pirjo; Iozzo Patricia The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity
without affecting hepatic fat content in humans. American journal of physiology. Endocrinology and metabolism 2008;295(2):E413-9.
2008: Slimani Lotfi; Kudomi Nobuyuki; Oikonen Vesa; Jarvisalo M; Kiss Jan; Naum Alexandru; Borra Ronald; Viljanen Antti; Sipila Hannu; Ferrannini Ele; Savunen Timo; Nuutila Pirjo; Iozzo Patricia
Quantification of liver perfusion with [(15)O]H(2)O-PET and its relationship with glucose metabolism and substrate levels.
Journal of hepatology 2008;48(6):974-82.
2008: Kalliokoski Teemu; Nuutila Pirjo; Virtanen Kirsi A; Iozzo Patricia; Bucci Marco; Svedström
Erkki; Roivainen Anne; Någren Kjell; Viljanen Tapio; Minn Heikki; Knuuti Juhani; Rönnemaa Tapani; Simell Olli
Pancreatic glucose uptake in vivo in men with newly diagnosed type 1 diabetes.
The Journal of clinical endocrinology and metabolism 2008;93(5):1909-14.
2008: Venojärvi Mika; Aunola Sirkka; Puhke Raivo; Marniemi Jukka; Hämäläinen Helena; Halonen
Jukka-Pekka; Lindström Jaana; Rastas Merja; Hällsten Kirsti; Nuutila Pirjo; Hänninen Osmo; Atalay Mustafa
Exercise training with dietary counselling increases mitochondrial chaperone expression in middle-aged subjects with impaired glucose tolerance.
BMC endocrine disorders 2008;8():3.
2007: Heinonen Ilkka; Nesterov Sergey V; Kemppainen Jukka; Nuutila Pirjo; Knuuti Juhani; Laitio
Ruut; Kjaer Michael; Boushel Robert; Kalliokoski Kari K Role of adenosine in regulating the heterogeneity of skeletal muscle blood flow during
exercise in humans.
Journal of applied physiology (Bethesda, Md. : 1985) 2007;103(6):2042-8.
2007: Nieminen Tuomo; Knuuti Juhani; Hämelahti Päivi; Kähönen Mika; Laaksonen Reijo; Janatuinen Tuula; Vesalainen Risto; Nuutila Pirjo; Jokela Hannu; Lehtimäki Terho
Coronary reactivity, homocysteine and methylenetetrahydrofolate reductase gene
variation in young men during pravastatin therapy. Vascular pharmacology 2007;47(2-3):113-7.
2007: Haltia Lauri T; Viljanen Antti; Parkkola Riitta; Kemppainen Nina; Rinne Juha O; Nuutila Pirjo;
Kaasinen Valtteri
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Brain white matter expansion in human obesity and the recovering effect of dieting.
The Journal of clinical endocrinology and metabolism 2007;92(8):3278-84.
2007: Laaksonen Marko S; Kalliokoski Kari K; Luotolahti Matti; Kemppainen Jukka; Teräs Mika; Kyröläinen Heikki; Nuutila Pirjo; Knuuti Juhani
Myocardial perfusion during exercise in endurance-trained and untrained humans.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(2):R837-43.
2007: Lautamäki Riikka; Rönnemaa Tapani; Huupponen Risto; Lehtimäki Terho; Iozzo Patricia; Airaksinen K E Juhani; Knuuti Juhani; Nuutila Pirjo
Low serum adiponectin is associated with high circulating oxidized low-density lipoprotein in patients with type 2 diabetes mellitus and coronary artery disease.
Metabolism: clinical and experimental 2007;56(7):881-6.
2007: Tuunanen Helena; Kuusisto Johanna; Toikka Jyri; Jääskeläinen Pertti; Marjamäki Päivi;
Peuhkurinen Keijo; Viljanen Tapio; Sipola Petri; Stolen Kira Q; Hannukainen Jarna; Nuutila Pirjo; Laakso Markku; Knuuti Juhani
Myocardial perfusion, oxidative metabolism, and free fatty acid uptake in patients with
hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene: a positron emission tomography study.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2007;14(3):354-65.
2007: Hannukainen J C; Janatuinen T; Toikka J O; Järvisalo M J; Heinonen O J; Kapanen J; Någren K; Nuutila P; Kujala U M; Kaprio J; Knuuti J; Kalliokoski K K
Myocardial and peripheral vascular functional adaptation to exercise training. Scandinavian journal of medicine & science in sports 2007;17(2):139-47.
2007: Kauhanen Saila; Seppänen Marko; Minn Heikki; Gullichsen Risto; Salonen Anna; Alanen Kalle; Parkkola Riitta; Solin Olof; Bergman Jörgen; Sane Timo; Salmi Jorma; Välimäki Matti; Nuutila Pirjo
Fluorine-18-L-dihydroxyphenylalanine (18F-DOPA) positron emission tomography as a
tool to localize an insulinoma or beta-cell hyperplasia in adult patients. The Journal of clinical endocrinology and metabolism 2007;92(4):1237-44.
2007: Naum Alexandru; Tuunanen Helena; Engblom Erik; Oikonen Vesa; Sipilä Hannu; Iozzo
Patricia; Nuutila Pirjo; Knuuti Juhani
Simultaneous evaluation of myocardial blood flow, cardiac function and lung water content using [15O]H2O and positron emission tomography.
European journal of nuclear medicine and molecular imaging 2007;34(4):563-72.
2007: Guiducci Letizia; Grönroos Tove; Järvisalo Mikko J; Kiss Jan; Viljanen Antti; Naum Alexandru
G; Viljanen Tapio; Savunen Timo; Knuuti Juhani; Ferrannini Ele; Salvadori Piero A; Nuutila Pirjo; Iozzo Patricia
Biodistribution of the fatty acid analogue 18F-FTHA: plasma and tissue partitioning between lipid pools during fasting and hyperinsulinemia.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2007;48(3):455-62.
2007: Iozzo Patricia; Jarvisalo Mikko J; Kiss Jan; Borra Ronald; Naum Gratian A; Viljanen Antti;
Viljanen Tapio; Gastaldelli Amalia; Buzzigoli Emma; Guiducci Letizia; Barsotti Elisabetta; Savunen
Timo; Knuuti Juhani; Haaparanta-Solin Merja; Ferrannini Ele; Nuutila Pirjo Quantification of liver glucose metabolism by positron emission tomography: validation
study in pigs. Gastroenterology 2007;132(2):531-42.
2007: Hannukainen Jarna C; Nuutila Pirjo; Borra Ronald; Kaprio Jaakko; Kujala Urho M; Janatuinen Tuula; Heinonen Olli J; Kapanen Jukka; Viljanen Tapio; Haaparanta Merja; Rönnemaa Tapani;
Parkkola Riitta; Knuuti Juhani; Kalliokoski Kari K Increased physical activity decreases hepatic free fatty acid uptake: a study in human
monozygotic twins.
The Journal of physiology 2007;578(Pt 1):347-58.
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2007: Ilveskoski E; Lehtimäki T; Laaksonen R; Janatuinen T; Vesalainen R; Nuutila P; Laippala P;
Karhunen P J; Knuuti J
Improvement of myocardial blood flow by lipid-lowering therapy with pravastatin is modulated by apolipoprotein E genotype.
Scandinavian journal of clinical and laboratory investigation 2007;67(7):723-34.
2007: Kähönen M; Lehtimäki T; Laaksonen R; Janatuinen T; Vesalainen R; Laine H; Raitakari O T;
Nuutila P; Knuuti J; Nieminen T Angiotensin-converting enzyme gene polymorphism and coronary reactivity in young
men. Scandinavian journal of clinical and laboratory investigation 2007;67(6):596-603.
2007: Luomala M; Laaksonen R; Janatuinen T; Vesalainen R; Nuutila P; Saarela M; Mattila K; Kalijärvi M; Solakivi T; Knuuti J; Hurme M; Lehtimäki T
High plasma levels of CD40 are associated with low coenzyme Q and vitamin E content of
low-density lipoprotein in healthy men. Scandinavian journal of clinical and laboratory investigation 2007;67(2):115-22.
2006: Tuunanen Helena; Engblom Erik; Naum Alexandru; Någren Kjell; Hesse Birger; Airaksinen K E
Juhani; Nuutila Pirjo; Iozzo Patricia; Ukkonen Heikki; Opie Lionel H; Knuuti Juhani
Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure.
Circulation 2006;114(20):2130-7.
2006: Kankaanpää Mikko; Lehto Hanna-Riikka; Pärkkä Jussi P; Komu Markku; Viljanen Antti;
Ferrannini Ele; Knuuti Juhani; Nuutila Pirjo; Parkkola Riitta; Iozzo Patricia Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to
left ventricular function and serum free fatty acid levels. The Journal of clinical endocrinology and metabolism 2006;91(11):4689-95.
2006: Hannukainen Jarna C; Nuutila Pirjo; Kaprio Jaakko; Heinonen Olli J; Kujala Urho M; Janatuinen Tuula; Rönnemaa Tapani; Kapanen Jukka; Haaparanta-Solin Merja; Viljanen Tapio; Knuuti
Juhani; Kalliokoski Kari K
Relationship between local perfusion and FFA uptake in human skeletal muscle-no effect of increased physical activity and aerobic fitness.
Journal of applied physiology (Bethesda, Md. : 1985) 2006;101(5):1303-11.
2006: Tuunanen Helena; Engblom Erik; Naum Alexandru; Scheinin Mika; Någren Kjell; Airaksinen
Juhani; Nuutila Pirjo; Iozzo Patricia; Ukkonen Heikki; Knuuti Juhani Decreased myocardial free fatty acid uptake in patients with idiopathic dilated
cardiomyopathy: evidence of relationship with insulin resistance and left ventricular dysfunction.
Journal of cardiac failure 2006;12(8):644-52.
2006: Kalliokoski Riikka J; Kalliokoski Kari K; Penttinen Maila; Kantola Ilkka; Leino Aila; Viikari Jorma
S; Simell Olli; Nuutila Pirjo; Raitakari Olli T Structural and functional changes in peripheral vasculature of Fabry patients.
Journal of inherited metabolic disease 2006;29(5):660-6.
2006: Tolvanen Tuula; Någren Kjell; Yu Meixiang; Sutinen Eija; Havu-Aurén Katja; Jyrkkiö Sirkku;
Asola Markku; Kotoneva Eira; Nuutila Pirjo; Minn Heikki
Human radiation dosimetry of [11C]MeAIB, a new tracer for imaging of system A amino acid transport.
European journal of nuclear medicine and molecular imaging 2006;33(10):1178-84.
2006: Fan Yue-Mei; Laaksonen Reijo; Janatuinen Tuula; Vesalainen Risto; Laine Hanna; Raitakari Olli
T; Nuutila Pirjo; Knuuti Juhani; Rontu Riikka; Lehtimäki Terho The influence of hepatic lipase C-480T polymorphism on coronary flow reserve in young
men is independent of the plasma cholesterol level. Atherosclerosis 2006;188(2):391-7.
Pirjo Nuutila 9
2006: Sundell Jan; Laine Hanna; Raitakari Olli T; Luotolahti Matti; Nuutila Pirjo; Knuuti Juhani
Positive family history of coronary artery disease is associated with reduced myocardial
vasoreactivity in healthy men. International journal of cardiology 2006;112(3):289-94.
2006: Slimani L; Oikonen V; Hällsten K; Savisto N; Knuuti J; Nuutila P; Iozzo P
Exercise restores skeletal muscle glucose delivery but not insulin-mediated glucose
transport and phosphorylation in obese subjects. The Journal of clinical endocrinology and metabolism 2006;91(9):3394-403.
2006: Lautamäki Riikka; Borra Ronald; Iozzo Patricia; Komu Markku; Lehtimäki Terho; Salmi Marko; Jalkanen Sirpa; Airaksinen K E Juhani; Knuuti Juhani; Parkkola Riitta; Nuutila Pirjo
Liver steatosis coexists with myocardial insulin resistance and coronary dysfunction in patients with type 2 diabetes.
American journal of physiology. Endocrinology and metabolism 2006;291(2):E282-90.
2006: Iozzo Patricia; Gastaldelli Amalia; Järvisalo Mikko J; Kiss Jan; Borra Ronald; Buzzigoli Emma;
Viljanen Antti; Naum G; Viljanen Tapio; Oikonen Vesa; Knuuti Juhani; Savunen Timo; Salvadori Piero A; Ferrannini Ele; Nuutila Pirjo
18F-FDG assessment of glucose disposal and production rates during fasting and insulin
stimulation: a validation study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(6):1016-22.
2006: Guiducci Letizia; Järvisalo Mikko; Kiss Jan; Någren Kjell; Viljanen Antti; Naum Alexandru G;
Gastaldelli Amalia; Savunen Timo; Knuuti Juhani; Salvadori Piero A; Ferrannini Ele; Nuutila Pirjo;
Iozzo Patricia [11C]palmitate kinetics across the splanchnic bed in arterial, portal and hepatic venous
plasma during fasting and euglycemic hyperinsulinemia. Nuclear medicine and biology 2006;33(4):521-8.
2006: Laaksonen M S; Kivelä R; Kyröläinen H; Sipilä S; Selänne H; Lautamäki R; Nuutila P; Knuuti J; Kalliokoski K K; Komi P V
Effects of exhaustive stretch-shortening cycle exercise on muscle blood flow during
exercise. Acta physiologica (Oxford, England) 2006;186(4):261-70.
2006: Laaksonen Marko S; Kyröläinen Heikki; Kalliokoski Kari K; Nuutila Pirjo; Knuuti Juhani
The association between muscle EMG and perfusion in knee extensor muscles.
Clinical physiology and functional imaging 2006;26(2):99-105.
2006: Sundell J; Laine H; Nuutila P; Luotolahti M; Knuuti J
Short-term changes in inflammatory response protein (hsCRP) do not parallel with changes in coronary vasoreactivity in obese men.
International journal of obesity (2005) 2006;30(3):460-7.
2006: Kalliokoski R J; Kantola I; Kalliokoski K K; Engblom E; Sundell J; Hannukainen J C; Janatuinen
T; Raitakari O T; Knuuti J; Penttinen M; Viikari J; Nuutila P The effect of 12-month enzyme replacement therapy on myocardial perfusion in patients
with Fabry disease. Journal of inherited metabolic disease 2006;29(1):112-8.
2006: Lautamäki Riikka; Airaksinen K E Juhani; Seppänen Marko; Toikka Jyri; Härkönen Risto; Luotolahti Matti; Borra Ronald; Sundell Jan; Knuuti Juhani; Nuutila Pirjo
Insulin improves myocardial blood flow in patients with type 2 diabetes and coronary artery disease.
Diabetes 2006;55(2):511-6.
2006: Otonkoski Timo; Näntö-Salonen Kirsti; Seppänen Marko; Veijola Riitta; Huopio Hanna; Hussain
Khalid; Tapanainen Päivi; Eskola Olli; Parkkola Riitta; Ekström Klas; Guiot Yves; Rahier Jacques;
Laakso Markku; Rintala Risto; Nuutila Pirjo; Minn Heikki Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron
Pirjo Nuutila 10
emission tomography.
Diabetes 2006;55(1):13-8.
2006: Lautamäki Riikka; Nuutila Pirjo; Airaksinen K E Juhani; Leino Aila; Hiekkanen Heikki; Turiceanu Marian; Stewart Murray; Knuuti Juhani; Rönnemaa Tapani
The effect of PPARgamma-agonism on LDL subclass profile in patients with type 2
diabetes and coronary artery disease. The review of diabetic studies : RDS 2006;3(1):31-8.
2005: Catrina Sergiu-Bogdan; Virtanen Kirsi; Hällsten Kirsti; Lönnqvist Fredrik; Nuutila Pirjo; Brismar Kerstin
Effect of rosiglitazone on early-morning plasma cortisol levels. Neuro endocrinology letters 2005;26(6):763-4; author reply 765.
2005: Vänttinen Markku; Nuutila Pirjo; Kuulasmaa Teemu; Pihlajamäki Jussi; Hällsten Kirsti; Virtanen Kirsi A; Lautamäki Riikka; Peltoniemi Pauliina; Takala Teemu; Viljanen Antti P M; Knuuti Juhani;
Laakso Markku Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta
gene are associated with skeletal muscle glucose uptake.
Diabetes 2005;54(12):3587-91.
2005: Viljanen Antti P M; Virtanen Kirsi A; Järvisalo Mikko J; Hällsten Kirsti; Parkkola Riitta;
Rönnemaa Tapani; Lönnqvist Fredrik; Iozzo Patricia; Ferrannini Ele; Nuutila Pirjo Rosiglitazone treatment increases subcutaneous adipose tissue glucose uptake in
parallel with perfusion in patients with type 2 diabetes: a double-blind, randomized study with metformin.
The Journal of clinical endocrinology and metabolism 2005;90(12):6523-8.
2005: Naum Alexandru; Laaksonen Marko S; Tuunanen Helena; Oikonen Vesa; Teräs Mika;
Kemppainen Jukka; Järvisalo Mikko J; Nuutila Pirjo; Knuuti Juhani Motion detection and correction for dynamic ( 15)O-water myocardial perfusion PET
studies.
European journal of nuclear medicine and molecular imaging 2005;32(12):1378-83.
2005: Kalliokoski Teemu; Simell Olli; Haaparanta Merja; Viljanen Tapio; Solin Olof; Knuuti Juhani; Nuutila Pirjo
An autoradiographic study of [(18)F]FDG uptake to islets of Langerhans in NOD mouse.
Diabetes research and clinical practice 2005;70(3):217-24.
2005: Hannukainen J; Kalliokoski K K; Nuutila P; Fujimoto T; Kemppainen J; Viljanen T; Laaksonen
M S; Parkkola R; Knuuti J; Kjaer M In vivo measurements of glucose uptake in human Achilles tendon during different
exercise intensities. International journal of sports medicine 2005;26(9):727-31.
2005: Venojärvi M; Puhke R; Hämäläinen H; Marniemi J; Rastas M; Rusko H; Nuutila P; Hänninen O; Aunola S
Role of skeletal muscle-fibre type in regulation of glucose metabolism in middle-aged subjects with impaired glucose tolerance during a long-term exercise and dietary
intervention.
Diabetes, obesity & metabolism 2005;7(6):745-54.
2005: Kemppainen Jukka; Aalto Sargo; Fujimoto Toshihiko; Kalliokoski Kari K; Långsjö Jaakko; Oikonen Vesa; Rinne Juha; Nuutila Pirjo; Knuuti Juhani
High intensity exercise decreases global brain glucose uptake in humans.
The Journal of physiology 2005;568(Pt 1):323-32.
2005: Lautamäki Riikka; Airaksinen K E Juhani; Seppänen Marko; Toikka Jyri; Luotolahti Matti; Ball
Elizabeth; Borra Ronald; Härkönen Risto; Iozzo Patricia; Stewart Murray; Knuuti Juhani; Nuutila Pirjo Rosiglitazone improves myocardial glucose uptake in patients with type 2 diabetes and
Pirjo Nuutila 11
coronary artery disease: a 16-week randomized, double-blind, placebo-controlled study.
Diabetes 2005;54(9):2787-94.
2005: Virtanen Kirsi A; Iozzo Patricia; Hällsten Kirsti; Huupponen Risto; Parkkola Riitta; Janatuinen Tuula; Lönnqvist Fredrik; Viljanen Tapio; Rönnemaa Tapani; Lönnroth Peter; Knuuti Juhani;
Ferrannini Ele; Nuutila Pirjo
Increased fat mass compensates for insulin resistance in abdominal obesity and type 2 diabetes: a positron-emitting tomography study.
Diabetes 2005;54(9):2720-6.
2005: Kauppinen-Mäkelin Ritva; Sane Timo; Reunanen Antti; Välimäki Matti J; Niskanen Leo;
Markkanen Helene; Löyttyniemi Eliisa; Ebeling Tapani; Jaatinen Pia; Laine Hanna; Nuutila Pirjo; Salmela Pasi; Salmi Jorma; Stenman Ulf-Håkan; Viikari Jorma; Voutilainen Erkki
A nationwide survey of mortality in acromegaly.
The Journal of clinical endocrinology and metabolism 2005;90(7):4081-6.
2005: Vänttinen Markku; Nuutila Pirjo; Pihlajamäki Jussi; Hällsten Kirsti; Virtanen Kirsi A; Lautamäki Riikka; Peltoniemi Pauliina; Kemppainen Jukka; Takala Teemu; Viljanen Antti P M; Knuuti Juhani;
Laakso Markku
The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-gamma2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission
tomography study. The Journal of clinical endocrinology and metabolism 2005;90(7):4249-54.
2005: Karlsson Håkan K R; Hällsten Kirsti; Björnholm Marie; Tsuchida Hiroki; Chibalin Alexander V; Virtanen Kirsi A; Heinonen Olli J; Lönnqvist Fredrik; Nuutila Pirjo; Zierath Juleen R
Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: a randomized controlled study.
Diabetes 2005;54(5):1459-67.
2005: Sundell Jan; Laine Hanna; Raitakari Olli T; Luotolahti Matti; Nuutila Pirjo; Viikari Jorma; Knuuti
Juhani
Increased lipoprotein(a) is associated with reduced myocardial vasoreactivity in young healthy men.
Atherosclerosis 2005;179(1):185-91.
2005: Kotilainen Pirkko; Airas Laura; Kojo Tiina; Kurki Timo; Kataja Kaisa; Minn Heikki; Nuutila Pirjo
Riedel's thyroiditis in a patient with multiple sclerosis. Neuro endocrinology letters 2005;26(1):67-8.
2005: Sundell J; Janatuinen T; Rönnemaa T; Naum A; Laine H; Luotolahti M; Nuutila P; Raitakari O
T; Knuuti J
Lifetime glycaemic exposure predicts reduced coronary vasoreactivity in Type 1 diabetic subjects.
Diabetic medicine : a journal of the British Diabetic Association 2005;22(1):45-51.
2005: Kalliokoski Kari K; Knuuti Juhani; Nuutila Pirjo
Relationship between muscle blood flow and oxygen uptake during exercise in endurance-trained and untrained men.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(1):380-3.
2005: Kalliokoski R J; Kalliokoski K K; Sundell J; Engblom E; Penttinen M; Kantola I; Raitakari O T;
Knuuti J; Nuutila P Impaired myocardial perfusion reserve but preserved peripheral endothelial function in
patients with Fabry disease.
Journal of inherited metabolic disease 2005;28(4):563-73.
2004: Hällsten K; Virtanen K A; Lönnqvist F; Janatuinen T; Turiceanu M; Rönnemaa T; Viikari J;
Lehtimäki T; Knuuti J; Nuutila P Enhancement of insulin-stimulated myocardial glucose uptake in patients with Type 2
Pirjo Nuutila 12
diabetes treated with rosiglitazone.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(12):1280-7.
2004: Kunnas Tarja A; Lehtimäki Terho; Karhunen Pekka J; Laaksonen Reijo; Janatuinen Tuula; Vesalainen Risto; Nuutila Pirjo; Knuuti Juhani; Nikkari Seppo T
Estrogen receptor genotype modulates myocardial perfusion in young men.
Journal of molecular medicine (Berlin, Germany) 2004;82(12):821-5.
2004: Sundell J; Rönnemaa T; Laine H; Raitakari O T; Luotolahti M; Nuutila P; Knuuti J
High-sensitivity C-reactive protein and impaired coronary vasoreactivity in young men with uncomplicated type 1 diabetes.
Diabetologia 2004;47(11):1888-94.
2004: Aittoniemi Janne; Fan Yue-Mei; Laaksonen Reijo; Janatuinen Tuula; Vesalainen Risto; Nuutila
Pirjo; Knuuti Juhani; Hulkkonen Janne; Hurme Mikko; Lehtimäki Terho The effect of mannan-binding lectin variant alleles on coronary artery reactivity in
healthy young men. International journal of cardiology 2004;97(2):317-8.
2004: Iozzo Patricia; Takala Teemu; Oikonen Vesa; Bergman Jörgen; Grönroos Tove; Ferrannini Ele; Nuutila Pirjo; Knuuti Juhani
Effect of training status on regional disposal of circulating free fatty acids in the liver and
skeletal muscle during physiological hyperinsulinemia. Diabetes care 2004;27(9):2172-7.
2004: Kalliokoski Kari K; Laaksonen Marko S; Luotolahti Matti; Laine Hanna; Takala Teemu O;
Nuutila Pirjo; Knuuti Juhani
Myocardial perfusion after marathon running. Scandinavian journal of medicine & science in sports 2004;14(4):208-14.
2004: Iozzo P; Lautamaki R; Geisler F; Virtanen K A; Oikonen V; Haaparanta M; Yki-Jarvinen H;
Ferrannini E; Knuuti J; Nuutila P
Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver.
Diabetologia 2004;47(7):1149-56.
2004: Iozzo Patricia; Turpeinen Anu K; Takala Teemu; Oikonen Vesa; Bergman Jörgen; Grönroos
Tove; Ferrannini Ele; Nuutila Pirjo; Knuuti Juhani Defective liver disposal of free fatty acids in patients with impaired glucose tolerance.
The Journal of clinical endocrinology and metabolism 2004;89(7):3496-502.
2004: Janatuinen Tuula; Knuuti Juhani; Toikka Jyri O; Ahotupa Markku; Nuutila Pirjo; Rönnemaa
Tapani; Raitakari Olli T Effect of pravastatin on low-density lipoprotein oxidation and myocardial perfusion in
young adults with type 1 diabetes.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(7):1303-8.
2004: Minn Heikki; Salonen Anna; Friberg Johan; Roivainen Anne; Viljanen Tapio; Långsjö Jaakko;
Salmi Jorma; Välimäki Matti; Någren Kjell; Nuutila Pirjo Imaging of adrenal incidentalomas with PET using (11)C-metomidate and (18)F-FDG.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004;45(6):972-9.
2004: Sundell J; Janatuinen T; Rönnemaa T; Raitakari O T; Toikka J; Nuutila P; Knuuti J
Diabetic background retinopathy is associated with impaired coronary vasoreactivity in people with Type 1 diabetes.
Diabetologia 2004;47(4):725-31.
2004: Stolen Kira Q; Kemppainen Jukka; Kalliokoski Kari K; Hällsten Kirsti; Luotolahti Matti; Karanko
Hannu; Lehikoinen Pertti; Viljanen Tapio; Salo Tiina; Airaksinen K E Juhani; Nuutila Pirjo; Knuuti Juhani
Myocardial perfusion reserve and oxidative metabolism contribute to exercise capacity in
Pirjo Nuutila 13
patients with dilated cardiomyopathy.
Journal of cardiac failure 2004;10(2):132-40.
2004: Kalliokoski Kari K; Knuuti Juhani; Nuutila Pirjo Blood transit time heterogeneity is associated to oxygen extraction in exercising human
skeletal muscle.
Microvascular research 2004;67(2):125-32.
2004: Mäkelä Riikka; Laaksonen Reijo; Janatuinen Tuula; Vesalainen Risto; Nuutila Pirjo; Jaakkola
Olli; Knuuti Juhani; Lehtimäki Terho Myeloperoxidase gene variation and coronary flow reserve in young healthy men.
Journal of biomedical science 2004;11(1):59-64.
2004: Stolen Kira Q; Kemppainen Jukka; Kalliokoski Kari K; Karanko Hannu; Toikka Jyri; Janatuinen
Tuula; Raitakari Olli T; Airaksinen K E Juhani; Nuutila Pirjo; Knuuti Juhani Myocardial perfusion reserve and peripheral endothelial function in patients with
idiopathic dilated cardiomyopathy. The American journal of cardiology 2004;93(1):64-8.
2004: Johansson Bo-Lennart; Sundell Jan; Ekberg Karin; Jonsson Cathrine; Seppänen Marko; Raitakari Olli; Luotolahti Matti; Nuutila Pirjo; Wahren John; Knuuti Juhani
C-peptide improves adenosine-induced myocardial vasodilation in type 1 diabetes
patients. American journal of physiology. Endocrinology and metabolism 2004;286(1):E14-9.
2004: Sundell Jan; Ala-Houhala Mari; Lewitt Moira; Laine Hanna; Nuutila Pirjo
[Non-islet cell tumor hypoglycemia]
Duodecim; lääketieteellinen aikakauskirja 2004;120(22):2689-92.
2004: Penttinen Maila; Kantola Ilkka; Nuutila Pirjo; Hietaharju Aki; Honkanen Eero; Kaitila Ilkka;
Niskanen Leo; Savolainen Markku; Viikari Jorma [Fabry's disease, recommendation for diagnostics, follow up and treatment in Finland]
Duodecim; lääketieteellinen aikakauskirja 2004;120(20):2407-14.
2004: Airas Laura; Korja Miikka; Soinio Minna; Nuutila Pirjo; Knip Mikael; Marttila Reijo J
[Stiff person syndrome] Duodecim; lääketieteellinen aikakauskirja 2004;120(15):1899-902.
2003: Roivainen Anne; Parkkola Riitta; Yli-Kerttula Timo; Lehikoinen Pertti; Viljanen Tapio; Möttönen
Timo; Nuutila Pirjo; Minn Heikki
Use of positron emission tomography with methyl-11C-choline and 2-18F-fluoro-2-deoxy-D-glucose in comparison with magnetic resonance imaging for the assessment of
inflammatory proliferation of synovium. Arthritis and rheumatism 2003;48(11):3077-84.
2003: Lehtimäki Terho; Laaksonen Reijo; Janatuinen Tuula; Vesalainen Risto; Nuutila Pirjo; Mattila Kari; Ilveskoski Erkki; Luomala Mari; Saikku Pekka; Knuuti Juhani; Hurme Mikko
Interleukin-1B genotype modulates the improvement of coronary artery reactivity by
lipid-lowering therapy with pravastatin: a placebo-controlled positron emission tomography study in young healthy men.
Pharmacogenetics 2003;13(10):633-9.
2003: Stolen Kira Q; Kemppainen Jukka; Kalliokoski Kari K; Luotolahti Matti; Viljanen Tapio; Nuutila
Pirjo; Knuuti Juhani Exercise training improves insulin-stimulated myocardial glucose uptake in patients with
dilated cardiomyopathy. Journal of nuclear cardiology : official publication of the American Society of Nuclear
Cardiology 2003;10(5):447-55.
2003: Kemppainen Jukka; Stolen Kira; Kalliokoski Kari K; Salo Tiina; Karanko Hannu; Viljanen Tapio;
Airaksinen Juhani; Nuutila Pirjo; Knuuti Juhani
Pirjo Nuutila 14
Exercise training improves insulin stimulated skeletal muscle glucose uptake
independent of changes in perfusion in patients with dilated cardiomyopathy. Journal of cardiac failure 2003;9(4):286-95.
2003: Kalliokoski K K; Laaksonen M S; Knuuti J; Nuutila P
Perfusion distribution between and within muscles during intermittent static exercise in
endurance-trained and untrained men. International journal of sports medicine 2003;24(6):400-3.
2003: Iozzo Patricia; Turpeinen Anu K; Takala Teemu; Oikonen Vesa; Solin Olof; Ferrannini Ele; Nuutila Pirjo; Knuuti Juhani
Liver uptake of free fatty acids in vivo in humans as determined with 14( R, S)-[18F]fluoro-6-thia-heptadecanoic acid and PET.
European journal of nuclear medicine and molecular imaging 2003;30(8):1160-4.
2003: Iozzo Patricia; Hallsten Kirsti; Oikonen Vesa; Virtanen Kirsi A; Parkkola Riitta; Kemppainen
Jukka; Solin Olof; Lonnqvist Fredrik; Ferrannini Ele; Knuuti Juhani; Nuutila Pirjo Effects of metformin and rosiglitazone monotherapy on insulin-mediated hepatic glucose
uptake and their relation to visceral fat in type 2 diabetes.
Diabetes care 2003;26(7):2069-74.
2003: Kemppainen Jukka; Tsuchida Hiroki; Stolen Kira; Karlsson Håkan; Björnholm Marie; Heinonen
Olli J; Nuutila Pirjo; Krook Anna; Knuuti Juhani; Zierath Juleen R Insulin signalling and resistance in patients with chronic heart failure.
The Journal of physiology 2003;550(Pt 1):305-15.
2003: Sundell Jan; Huupponen Risto; Raitakari Olli T; Nuutila Pirjo; Knuuti Juhani
High serum leptin is associated with attenuated coronary vasoreactivity. Obesity research 2003;11(6):776-82.
2003: Fujimoto Toshihiko; Kemppainen Jukka; Kalliokoski Kari K; Nuutila Pirjo; Ito Masatoshi; Knuuti
Juhani
Skeletal muscle glucose uptake response to exercise in trained and untrained men. Medicine and science in sports and exercise 2003;35(5):777-83.
2003: Iozzo Patricia; Geisler Fabian; Oikonen Vesa; Mäki Maija; Takala Teemu; Solin Olof; Ferrannini Ele; Knuuti Juhani; Nuutila Pirjo;
Insulin stimulates liver glucose uptake in humans: an 18F-FDG PET Study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003;44(5):682-9.
2003: Iozzo Patricia; Hallsten Kirsti; Oikonen Vesa; Virtanen Kirsi A; Kemppainen Jukka; Solin Olof; Ferrannini Ele; Knuuti Juhani; Nuutila Pirjo
Insulin-mediated hepatic glucose uptake is impaired in type 2 diabetes: evidence for a relationship with glycemic control.
The Journal of clinical endocrinology and metabolism 2003;88(5):2055-60.
2003: Laaksonen Marko S; Kalliokoski Kari K; Kyröläinen Heikki; Kemppainen Jukka; Teräs Mika;
Sipilä Hannu; Nuutila Pirjo; Knuuti Juhani
Skeletal muscle blood flow and flow heterogeneity during dynamic and isometric exercise in humans.
American journal of physiology. Heart and circulatory physiology 2003;284(3):H979-86.
2003: Kalliokoski Kari K; Laaksonen Marko S; Takala Teemu O; Knuuti Juhani; Nuutila Pirjo
Muscle oxygen extraction and perfusion heterogeneity during continuous and intermittent static exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;94(3):953-8.
2003: Hällsten Kirsti; Yki-Järvinen Hannele; Peltoniemi Pauliina; Oikonen Vesa; Takala Teemu;
Kemppainen Jukka; Laine Hanna; Bergman Jörgen; Bolli Geremia B; Knuuti Juhani; Nuutila Pirjo Insulin- and exercise-stimulated skeletal muscle blood flow and glucose uptake in obese
Pirjo Nuutila 15
men.
Obesity research 2003;11(2):257-65.
2003: Stolen Kira Q; Kemppainen Jukka; Ukkonen Heikki; Kalliokoski Kari K; Luotolahti Matti; Lehikoinen Pertti; Hämäläinen Helena; Salo Tiina; Airaksinen K E Juhani; Nuutila Pirjo; Knuuti Juhani
Exercise training improves biventricular oxidative metabolism and left ventricular
efficiency in patients with dilated cardiomyopathy. Journal of the American College of Cardiology 2003;41(3):460-7.
2003: Virtanen Kirsi A; Hällsten Kirsti; Parkkola Riitta; Janatuinen Tuula; Lönnqvist Fredrik; Viljanen Tapio; Rönnemaa Tapani; Knuuti Juhani; Huupponen Risto; Lönnroth Peter; Nuutila Pirjo
Differential effects of rosiglitazone and metformin on adipose tissue distribution and glucose uptake in type 2 diabetic subjects.
Diabetes 2003;52(2):283-90.
2003: Sundell Jan; Laine Hanna; Luotolahti Matti; Nuutila Pirjo; Kalliokoski Kari; Raitakari Olli; Knuuti
Juhani Blunted coronary vasoreactivity to insulin is an early alteration in hypertension.
Journal of vascular research 2003;40(1):58-67.
2003: Kalliokoski Kari K; Kuusela Tom A; Laaksonen Marko S; Knuuti Juhani; Nuutila Pirjo
Muscle fractal vascular branching pattern and microvascular perfusion heterogeneity in
endurance-trained and untrained men. The Journal of physiology 2003;546(Pt 2):529-35.
2003: Janatuinen Tuula; Laakso Juha; Laaksonen Reijo; Vesalainen Risto; Nuutila Pirjo; Lehtimäki
Terho; Raitakari Olli T; Knuuti Juhani
Plasma asymmetric dimethylarginine modifies the effect of pravastatin on myocardial blood flow in young adults.
Vascular medicine (London, England) 2003;8(3):185-9.
2002: Kunnas Tarja A; Lehtimäki Terho; Laaksonen Reijo; Ilveskoski Erkki; Janatuinen Tuula;
Vesalainen Risto; Nuutila Pirjo; Karhunen Pekka J; Knuuti Juhani; Nikkari Seppo T Endothelial nitric oxide synthase genotype modulates the improvement of coronary
blood flow by pravastatin: a placebo-controlled PET study. Journal of molecular medicine (Berlin, Germany) 2002;80(12):802-7.
2002: Takala Teemu O; Nuutila Pirjo; Pulkki Kari; Oikonen Vesa; Grönroos Tove; Savunen Timo; Vähäsilta Tommi; Luotolahti Matti; Kallajoki Markku; Bergman Jörgen; Forsback Sarita; Knuuti Juhani
14(R,S)-[18F]Fluoro-6-thia-heptadecanoic acid as a tracer of free fatty acid uptake and
oxidation in myocardium and skeletal muscle. European journal of nuclear medicine and molecular imaging 2002;29(12):1617-22.
2002: Hällsten Kirsti; Virtanen Kirsi A; Lönnqvist Fredrik; Sipilä Hannu; Oksanen Airi; Viljanen Tapio;
Rönnemaa Tapani; Viikari Jorma; Knuuti Juhani; Nuutila Pirjo
Rosiglitazone but not metformin enhances insulin- and exercise-stimulated skeletal muscle glucose uptake in patients with newly diagnosed type 2 diabetes.
Diabetes 2002;51(12):3479-85.
2002: Laaksonen R; Janatuinen T; Vesalainen R; Lehtimäki T; Elovaara I; Jaakkola O; Jokela H;
Laakso J; Nuutila P; Punnonen K; Raitakari O; Saikku P; Salminen K; Knuuti J High oxidized LDL and elevated plasma homocysteine contribute to the early reduction of
myocardial flow reserve in healthy adults. European journal of clinical investigation 2002;32(11):795-802.
2002: Asola Markku R; Virtanen Kirsi A; Peltoniemi Pauliina; Någren Kjell; Yu Meixiang; Mattila Kari; Jyrkkiö Sirkku; Metsärinne Kaj; Nuutila Pirjo; Knuuti Juhani
Amino acid uptake in the skeletal muscle measured using [11C]methylaminoisobutyrate
(MEAIB) and PET. European journal of nuclear medicine and molecular imaging 2002;29(11):1485-91.
Pirjo Nuutila 16
2002: Sundell Jan; Laine Hanna; Luotolahti Matti; Nuutila Pirjo; Knuuti Juhani
Increased coronary vascular resistance cannot be reduced by inhibiting sympathetic
overactivity in hypertension. Journal of vascular research 2002;39(5):456-62.
2002: Virtanen Kirsi A; Lönnroth Peter; Parkkola Riitta; Peltoniemi Pauliina; Asola Markku; Viljanen
Tapio; Tolvanen Tuula; Knuuti Juhani; Rönnemaa Tapani; Huupponen Risto; Nuutila Pirjo
Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans.
The Journal of clinical endocrinology and metabolism 2002;87(8):3902-10.
2002: Kemppainen Jukka; Fujimoto Toshihiko; Kalliokoski Kari K; Viljanen Tapio; Nuutila Pirjo;
Knuuti Juhani Myocardial and skeletal muscle glucose uptake during exercise in humans.
The Journal of physiology 2002;542(Pt 2):403-12.
2002: Sundell Jan; Laine Hanna; Luotolahti Matti; Kalliokoski Kari; Raitakari Olli; Nuutila Pirjo; Knuuti
Juhani Obesity affects myocardial vasoreactivity and coronary flow response to insulin.
Obesity research 2002;10(7):617-24.
2002: Sundell J; Laine H; Nuutila P; Rönnemaa T; Luotolahti M; Raitakari O; Knuuti J
The effects of insulin and short-term hyperglycaemia on myocardial blood flow in young
men with uncomplicated Type I diabetes. Diabetologia 2002;45(6):775-82.
2002: Lehtimäki T; Laaksonen R; Mattila K M; Janatuinen T; Vesalainen R; Nuutila P; Laakso J;
Jaakkola O; Koivula T; Knuuti J
Oestrogen receptor gene variation is a determinant of coronary reactivity in healthy young men.
European journal of clinical investigation 2002;32(6):400-4.
2002: Kalliokoski Kari K; Nuutila Pirjo; Laine Hanna; Luotolahti Matti; Janatuinen Tuula; Raitakari Olli
T; Takala Teemu O; Knuuti Juhani Myocardial perfusion and perfusion reserve in endurance-trained men.
Medicine and science in sports and exercise 2002;34(6):948-53.
2002: Sundell Jan; Nuutila Pirjo; Laine Hanna; Luotolahti Matti; Kalliokoski Kari; Raitakari Olli; Knuuti
Juhani Dose-dependent vasodilating effects of insulin on adenosine-stimulated myocardial
blood flow.
Diabetes 2002;51(4):1125-30.
2002: Virtanen K A; Haaparanta M; Grönroos T; Bergman J; Solin O; Rouru J; Nuutila P; Huupponen R
2-[(18)F]fluoro-2-deoxy-D-glucose combined with microdialysis can be used for the
comparison of tissue glucose metabolism in obese and lean rats. Diabetes, obesity & metabolism 2002;4(1):60-8.
2002: Janatuinen Tuula; Friberg Johan; Viljanen Matti K; Raitakari Olli T; Nuutila Pirjo; Vainionpää
Raija; Oksi Jarmo; Peltonen Reijo; Engblom Erik; Laine Hanna; Knuuti Juhani
Early impairment of coronary flow reserve is not associated with Chlamydia pneumoniae antibodies.
Annals of medicine 2002;34(4):284-90.
2002: Porela Pekka; Nuutila Pirjo; Kantola Ilkka
[Periodic hypokalemic thyrotoxic paralysis] Duodecim; lääketieteellinen aikakauskirja 2002;118(14):1481-3.
2001: Virtanen K A; Peltoniemi P; Marjamäki P; Asola M; Strindberg L; Parkkola R; Huupponen R; Knuuti J; Lönnroth P; Nuutila P
Pirjo Nuutila 17
Human adipose tissue glucose uptake determined using [(18)F]-fluoro-deoxy-glucose
([(18)F]FDG) and PET in combination with microdialysis. Diabetologia 2001;44(12):2171-9.
2001: Peltoniemi P; Yki-Järvinen H; Laine H; Oikonen V; Rönnemaa T; Kalliokoski K; Raitakari O;
Knuuti M J; Nuutila P
Evidence for spatial heterogeneity in insulin- and exercise-induced increases in glucose uptake: studies in normal subjects and patients with type 1 diabetes.
The Journal of clinical endocrinology and metabolism 2001;86(11):5525-33.
2001: Fan Y M; Laaksonen R; Janatuinen T; Vesalainen R; Nuutila P; Knuuti J; Lehtimäki T
Effects of pravastatin therapy on serum lipids and coronary reactivity are not associated with SREBP cleavage-activating protein polymorphism in healthy young men.
Clinical genetics 2001;60(4):319-21.
2001: Malin R; Laaksonen R; Knuuti J; Janatuinen T; Vesalainen R; Nuutila P; Lehtimäki T
Paraoxonase genotype modifies the effect of pravastatin on high-density lipoprotein cholesterol.
Pharmacogenetics 2001;11(7):625-33.
2001: Janatuinen T; Laaksonen R; Vesalainen R; Raitakari O; Lehtimäki T; Nuutila P; Knuuti J
Effect of lipid-lowering therapy with pravastatin on myocardial blood flow in young
mildly hypercholesterolemic adults. Journal of cardiovascular pharmacology 2001;38(4):561-8.
2001: Bertoldo A; Peltoniemi P; Oikonen V; Knuuti J; Nuutila P; Cobelli C
Kinetic modeling of [(18)F]FDG in skeletal muscle by PET: a four-compartment five-rate-
constant model. American journal of physiology. Endocrinology and metabolism 2001;281(3):E524-36.
2001: Malin R; Knuuti J; Janatuinen T; Laaksonen R; Vesalainen R; Nuutila P; Jokela H; Laakso J;
Jaakkola O; Solakivi T; Lehtimäki T
Paraoxonase gene polymorphisms and coronary reactivity in young healthy men. Journal of molecular medicine (Berlin, Germany) 2001;79(8):449-58.
2001: Peltoniemi P; Yki-Järvinen H; Oikonen V; Oksanen A; Takala T O; Rönnemaa T; Erkinjuntti M; Knuuti M J; Nuutila P
Resistance to exercise-induced increase in glucose uptake during hyperinsulinemia in insulin-resistant skeletal muscle of patients with type 1 diabetes.
Diabetes 2001;50(6):1371-7.
2001: Kalliokoski K K; Oikonen V; Takala T O; Sipilä H; Knuuti J; Nuutila P
Enhanced oxygen extraction and reduced flow heterogeneity in exercising muscle in endurance-trained men.
American journal of physiology. Endocrinology and metabolism 2001;280(6):E1015-21.
2001: Kalliokoski K K; Kuusela T A; Nuutila P; Tolvanen T; Oikonen V; Teräs M; Takala T E; Knuuti J
Perfusion heterogeneity in human skeletal muscle: fractal analysis of PET data.
European journal of nuclear medicine 2001;28(4):450-6.
2001: Knuuti J; Takala T O; Någren K; Sipilä H; Turpeinen A K; Uusitupa M I; Nuutila P Myocardial fatty acid oxidation in patients with impaired glucose tolerance.
Diabetologia 2001;44(2):184-7.
2000: Nuutila P; Kalliokoski K
Use of positron emission tomography in the assessment of skeletal muscle and tendon
metabolism and perfusion. Scandinavian journal of medicine & science in sports 2000;10(6):346-50.
2000: Kalliokoski K K; Kemppainen J; Larmola K; Takala T O; Peltoniemi P; Oksanen A; Ruotsalainen
U; Cobelli C; Knuuti J; Nuutila P
Muscle blood flow and flow heterogeneity during exercise studied with positron emission
Pirjo Nuutila 18
tomography in humans.
European journal of applied physiology 2000;83(4 -5):395-401.
2000: Peltoniemi P; Lönnroth P; Laine H; Oikonen V; Tolvanen T; Grönroos T; Strindberg L; Knuuti J; Nuutila P
Lumped constant for [(18)F]fluorodeoxyglucose in skeletal muscles of obese and
nonobese humans. American journal of physiology. Endocrinology and metabolism 2000;279(5):E1122-30.
2000: Nuutila P; Peltoniemi P; Oikonen V; Larmola K; Kemppainen J; Takala T; Sipilä H; Oksanen A; Ruotsalainen U; Bolli G B; Yki-Järvinen H
Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans: studies using [15O]O2, [15O]H2O, [18F]fluoro-
deoxy-glucose, and positron emission tomography.
Diabetes 2000;49(7):1084-91.
1999: Knuuti J; Nuutila P PET as a cardiovascular and metabolic research tool.
Annals of medicine 1999;31(6):450-6.
1999: Pitkanen O P; Laine H; Kemppainen J; Eronen E; Alanen A; Raitakari M; Kirvela O;
Ruotsalainen U; Knuuti J; Koivisto V A; Nuutila P
Sodium nitroprusside increases human skeletal muscle blood flow, but does not change flow distribution or glucose uptake.
The Journal of physiology 1999;521 Pt 3():729-37.
1999: Laine H; Katoh C; Luotolahti M; Yki-Järvinen H; Kantola I; Jula A; Takala T O; Ruotsalainen U;
Iida H; Haaparanta M; Nuutila P; Knuuti J Myocardial oxygen consumption is unchanged but efficiency is reduced in patients with
essential hypertension and left ventricular hypertrophy. Circulation 1999;100(24):2425-30.
1999: Takala T O; Nuutila P; Katoh C; Luotolahti M; Bergman J; Mäki M; Oikonen V; Ruotsalainen U; Grönroos T; Haaparanta M; Kapanen J; Knuuti J
Myocardial blood flow, oxygen consumption, and fatty acid uptake in endurance athletes during insulin stimulation.
The American journal of physiology 1999;277(4 Pt 1):E585-90.
1999: Turpeinen A K; Takala T O; Nuutila P; Axelin T; Luotolahti M; Haaparanta M; Bergman J;
Hämäläinen H; Iida H; Mäki M; Uusitupa M I; Knuuti J
Impaired free fatty acid uptake in skeletal muscle but not in myocardium in patients with impaired glucose tolerance: studies with PET and 14(R,S)-[18F]fluoro-6-thia-
heptadecanoic acid. Diabetes 1999;48(6):1245-50.
1999: Katoh C; Ruotsalainen U; Laine H; Alenius S; Iida H; Nuutila P; Knuuti J Iterative reconstruction based on median root prior in quantification of myocardial blood
flow and oxygen metabolism. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1999;40(5):862-7.
1999: Takala T O; Nuutila P; Knuuti J; Luotolahti M; Yki-Järvinen H Insulin action on heart and skeletal muscle glucose uptake in weight lifters and
endurance athletes. The American journal of physiology 1999;276(4 Pt 1):E706-11.
1999: Pitkänen O P; Nuutila P; Raitakari O T; Porkka K; Iida H; Nuotio I; Rönnemaa T; Viikari J; Taskinen M R; Ehnholm C; Knuuti J
Coronary flow reserve in young men with familial combined hyperlipidemia.
Circulation 1999;99(13):1678-84.
Pirjo Nuutila 19
1999: Rönnemaa E M; Rönnemaa T; Utriainen T; Raitakari M; Laine H; Takala T; Pitkänen O P;
Kirvelä O; Knuuti J; Nuutila P
Decreased blood flow but unaltered insulin sensitivity of glucose uptake in skeletal muscle of chronic smokers.
Metabolism: clinical and experimental 1999;48(2):239-44.
1998: Mäki M T; Haaparanta M; Nuutila P; Oikonen V; Luotolahti M; Eskola O; Knuuti J M
Free fatty acid uptake in the myocardium and skeletal muscle using fluorine-18-fluoro-6-thia-heptadecanoic acid.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1998;39(8):1320-7.
1998: Laine H; Raitakari O T; Niinikoski H; Pitkänen O P; Iida H; Viikari J; Nuutila P; Knuuti J
Early impairment of coronary flow reserve in young men with borderline hypertension. Journal of the American College of Cardiology 1998;32(1):147-53.
1998: Kinnala A; Manner T; Nuutila P; Korvenranta H; Kero P Differences in respiratory metabolism during treatment of hypoglycemia in infants of
diabetic mothers and small-for-gestational-age infants. American journal of perinatology 1998;15(6):363-7.
1998: Laine H; Knuuti M J; Ruotsalainen U; Utriainen T; Oikonen V; Raitakari M; Luotolahti M; Kirvelä O; Vicini P; Cobelli C; Nuutila P; Yki-Järvinen H
Preserved relative dispersion but blunted stimulation of mean flow, absolute dispersion,
and blood volume by insulin in skeletal muscle of patients with essential hypertension. Circulation 1998;97(21):2146-53.
1998: Utriainen T; Takala T; Luotolahti M; Rönnemaa T; Laine H; Ruotsalainen U; Haaparanta M;
Nuutila P; Yki-Järvinen H
Insulin resistance characterizes glucose uptake in skeletal muscle but not in the heart in NIDDM.
Diabetologia 1998;41(5):555-9.
1998: Laine H; Yki-Jarvinen H; Kirvela O; Tolvanen T; Raitakari M; Solin O; Haaparanta M; Knuuti J;
Nuutila P Insulin resistance of glucose uptake in skeletal muscle cannot be ameliorated by
enhancing endothelium-dependent blood flow in obesity. The Journal of clinical investigation 1998;101(5):1156-62.
1998: Laine H; Knuuti M J; Ruotsalainen U; Raitakari M; Iida H; Kapanen J; Kirvelä O; Haaparanta M; Yki-Järvinen H; Nuutila P
Insulin resistance in essential hypertension is characterized by impaired insulin
stimulation of blood flow in skeletal muscle. Journal of hypertension 1998;16(2):211-9.
1998: Pitkänen O P; Nuutila P; Raitakari O T; Rönnemaa T; Koskinen P J; Iida H; Lehtimäki T J;
Laine H K; Takala T; Viikari J S; Knuuti J
Coronary flow reserve is reduced in young men with IDDM. Diabetes 1998;47(2):248-54.
1997: Raitakari M; Nuutila P; Knuuti J; Raitakari O T; Laine H; Ruotsalainen U; Kirvelä O; Takala T
O; Iida H; Yki-Järvinen H
Effects of insulin on blood flow and volume in skeletal muscle of patients with IDDM: studies using [15O]H2O, [15O]CO, and positron emission tomography.
Diabetes 1997;46(12):2017-21.
1997: Mäki M T; Haaparanta M T; Luotolahti M S; Nuutila P; Voipio-Pulkki L M; Bergman J R; Solin O
H; Knuuti J M Fatty acid uptake is preserved in chronically dysfunctional but viable myocardium.
The American journal of physiology 1997;273(5 Pt 2):H2473-80.
Pirjo Nuutila 20
1997: Vicini P; Bonadonna R C; Utriainen T; Nuutila P; Raitakari M; Yki-Järvinen H; Cobelli C
Estimation of blood flow heterogeneity distribution in human skeletal muscle from
positron emission tomography data. Annals of biomedical engineering 1997;25(5):906-10.
1997: Mäki M; Nuutila P; Laine H; Voipio-Pulkki L M; Haaparanta M; Solin O; Knuuti J M
Myocardial glucose uptake in patients with NIDDM and stable coronary artery disease.
Diabetes 1997;46(9):1491-6.
1997: Utriainen T; Nuutila P; Takala T; Vicini P; Ruotsalainen U; Rönnemaa T; Tolvanen T; Raitakari
M; Haaparanta M; Kirvelä O; Cobelli C; Yki-Järvinen H Intact insulin stimulation of skeletal muscle blood flow, its heterogeneity and
redistribution, but not of glucose uptake in non-insulin-dependent diabetes mellitus. The Journal of clinical investigation 1997;100(4):777-85.
1997: Kinnala A; Nuutila P; Ruotsalainen U; Teräs M; Bergman J; Haaparanta M; Solin O; Korvenranta H; Aärimaa T; Wegelius U; Kero P; Suhonen-Polvi H
Cerebral metabolic rate for glucose after neonatal hypoglycaemia. Early human development 1997;49(1):63-72.
1997: Pitkanen O P; Raitakari O T; Ronnemaa T; Niinikoski H; Nuutila P; Iida H; Viikari J S; Knuuti J Influence of cardiovascular risk status on coronary flow reserve in healthy young men.
The American journal of cardiology 1997;79(12):1690-2.
1997: Ruotsalainen U; Raitakari M; Nuutila P; Oikonen V; Sipilä H; Teräs M; Knuuti M J; Bloomfield P
M; Iida H Quantitative blood flow measurement of skeletal muscle using oxygen-15-water and
PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1997;38(2):314-9.
1997: Malminiemi K; Laine H; Knuuti M J; Ruotsalainen U; Oikonen V; Haaparanta M; Nuutila P Acute effects of celiprolol on muscle blood flow and insulin sensitivity: studies using
[15O]-water, [18F]-fluorodeoxyglucose and positron emission tomography.
European journal of clinical pharmacology 1997;52(1):19-26.
1996: Pitkänen O P; Raitakari O T; Niinikoski H; Nuutila P; Iida H; Voipio-Pulkki L M; Härkönen R;
Wegelius U; Rönnemaa T; Viikari J; Knuuti J Coronary flow reserve is impaired in young men with familial hypercholesterolemia.
Journal of the American College of Cardiology 1996;28(7):1705-11.
1996: Raitakari M; Nuutila P; Ruotsalainen U; Laine H; Teräs M; Iida H; Mäkimattila S; Utriainen T;
Oikonen V; Sipilä H; Haaparanta M; Solin O; Wegelius U; Knuuti J; Yki-Järvinen H Evidence for dissociation of insulin stimulation of blood flow and glucose uptake in
human skeletal muscle: studies using [15O]H2O, [18F]fluoro-2-deoxy-D-glucose, and positron emission tomography.
Diabetes 1996;45(11):1471-7.
1996: Raitakari M; Nuutila P; Ruotsalainen U; Teräs M; Eronen E; Laine H; Raitakari O T; Iida H;
Knuuti M J; Yki-Järvinen H
Relationship between limb and muscle blood flow in man. The Journal of physiology 1996;496 ( Pt 2)():543-9.
1996: Kinnala A; Suhonen-Polvi H; Aärimaa T; Kero P; Korvenranta H; Ruotsalainen U; Bergman J;
Haaparanta M; Solin O; Nuutila P; Wegelius U
Cerebral metabolic rate for glucose during the first six months of life: an FDG positron emission tomography study.
Archives of disease in childhood. Fetal and neonatal edition 1996;74(3):F153-7.
1996: Mäki M; Luotolahti M; Nuutila P; Iida H; Voipio-Pulkki L M; Ruotsalainen U; Haaparanta M;
Solin O; Hartiala J; Härkönen R; Knuuti J
Pirjo Nuutila 21
Glucose uptake in the chronically dysfunctional but viable myocardium.
Circulation 1996;93(9):1658-66.
1996: Nuutila P; Raitakari M; Laine H; Kirvelä O; Takala T; Utriainen T; Mäkimattila S; Pitkänen O P; Ruotsalainen U; Iida H; Knuuti J; Yki-Järvinen H
Role of blood flow in regulating insulin-stimulated glucose uptake in humans. Studies
using bradykinin, [15O]water, and [18F]fluoro-deoxy-glucose and positron emission tomography.
The Journal of clinical investigation 1996;97(7):1741-7.
1995: Knuuti J; Nuutila P; Voipio-Pulkki L M
[18F]FDG in measuring myocardial glucose uptake. Circulation 1995;92(10):3146-8.
1995: Nuutila P; Mäki M; Laine H; Knuuti M J; Ruotsalainen U; Luotolahti M; Haaparanta M; Solin O; Jula A; Koivisto V A
Insulin action on heart and skeletal muscle glucose uptake in essential hypertension. The Journal of clinical investigation 1995;96(2):1003-9.
1995: Knuuti M J; Mäki M; Yki-Järvinen H; Voipio-Pulkki L M; Härkönen R; Haaparanta M; Nuutila P The effect of insulin and FFA on myocardial glucose uptake.
Journal of molecular and cellular cardiology 1995;27(7):1359-67.
1995: Nuutila P; Knuuti M J; Mäki M; Laine H; Ruotsalainen U; Teräs M; Haaparanta M; Solin O; Yki-
Järvinen H Gender and insulin sensitivity in the heart and in skeletal muscles. Studies using positron
emission tomography.
Diabetes 1995;44(1):31-6.
1994: Nuutila P; Knuuti M J; Raitakari M; Ruotsalainen U; Teräs M; Voipio-Pulkki L M; Haaparanta M;
Solin O; Wegelius U; Yki-Järvinen H Effect of antilipolysis on heart and skeletal muscle glucose uptake in overnight fasted
humans. The American journal of physiology 1994;267(6 Pt 1):E941-6.
1994: Nuutila P; Knuuti M J; Heinonen O J; Ruotsalainen U; Teräs M; Bergman J; Solin O; Yki-Järvinen H; Voipio-Pulkki L M; Wegelius U
Different alterations in the insulin-stimulated glucose uptake in the athlete's heart and skeletal muscle.
The Journal of clinical investigation 1994;93(5):2267-74.
1994: Knuuti M J; Saraste M; Nuutila P; Härkönen R; Wegelius U; Haapanen A; Bergman J;
Haaparanta M; Savunen T; Voipio-Pulkki L M Myocardial viability: fluorine-18-deoxyglucose positron emission tomography in
prediction of wall motion recovery after revascularization.
American heart journal 1994;127(4 Pt 1):785-96.
1994: Minn H; Nuutila P; Lindholm P; Ruotsalainen U; Bergman J; Teräs M; Knuuti M J
In vivo effects of insulin on tumor and skeletal muscle glucose metabolism in patients with lymphoma.
Cancer 1994;73(5):1490-8.
1993: Knuuti M J; Nuutila P; Ruotsalainen U; Teräs M; Saraste M; Härkönen R; Ahonen A; Wegelius
U; Haapanen A; Bergman J The value of quantitative analysis of glucose utilization in detection of myocardial
viability by PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1993;34(12):2068-75.
1993: Voipio-Pulkki L M; Nuutila P; Knuuti M J; Ruotsalainen U; Haaparanta M; Teräs M; Wegelius U; Koivisto V A
Heart and skeletal muscle glucose disposal in type 2 diabetic patients as determined by
Pirjo Nuutila 22
positron emission tomography.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1993;34(12):2064-7.
1993: Nuutila P; Knuuti J; Ruotsalainen U; Koivisto V A; Eronen E; Teräs M; Bergman J; Haaparanta M; Voipio-Pulkki L M; Viikari J
Insulin resistance is localized to skeletal but not heart muscle in type 1 diabetes.
The American journal of physiology 1993;264(5 Pt 1):E756-62.
1992: Knuuti M J; Nuutila P; Ruotsalainen U; Saraste M; Härkönen R; Ahonen A; Teräs M;
Haaparanta M; Wegelius U; Haapanen A Euglycemic hyperinsulinemic clamp and oral glucose load in stimulating myocardial
glucose utilization during positron emission tomography. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1992;33(7):1255-62.
1992: Nuutila P; Koivisto V A; Knuuti J; Ruotsalainen U; Teräs M; Haaparanta M; Bergman J; Solin O; Voipio-Pulkki L M; Wegelius U
Glucose-free fatty acid cycle operates in human heart and skeletal muscle in vivo. The Journal of clinical investigation 1992;89(6):1767-74.
1991: Voipio-Pulkki L M; Ruotsalainen U; Nuutila P; Någren K Myocardial 11C-palmitate kinetics in patients with coronary heart disease. Effect of non-
insulin dependent diabetes mellitus.
Acta radiologica. Supplementum 1991;376():142-3.
