Publications 2013-2018 · catalysis in a 2’-5’ lariat forming ribozyme Journal of the American...

Publications 2013-2018

(As of 01.2018)

Publications are sorted by Topics, PIs (alphabetical order; topic affiliation as of 01.2018), year of

publication (latest first) and author/title.

For PIs that have only been recruited to HZI during the current POF period, separate lists of

publications that appeared before their joining HZI are given.

For PIs that have left HZI during the current POF period, only the publications still published with HZI

affiliation are listed.

HZI publications not directly associated with any of the indicated PIs are not listed.

In contrast to the publication lists given in Volumes 1 and 2 of the Status Report, shared authorships

are not specifically indicated.

* = Author with HZI affiliation

Content Topic 1 ............................................................. 1

Blankenfeldt, Wulf ....................................... 1

Carlomagno, Teresa ..................................... 4

Charpentier, Emmanuelle ........................... 7

Dersch, Petra ............................................... 9

Engelmann, Susanne ................................. 12

Erhardt, Marc ............................................ 14

Geffers, Robert .......................................... 16

Goffinet, Christine ..................................... 25

Häussler, Susanne...................................... 26

Höfle Manfred G. ....................................... 31

Kolbe, Michael ........................................... 33

Krause, Gérard ........................................... 34

McHardy, Alice C. ...................................... 38

Mikolajczyk, Rafael T. ................................ 42

Pieper, Dietmar ......................................... 49

Pietschmann, Thomas ............................... 57

Rohde, Manfred ........................................ 64

Rottner, Klemens ....................................... 78

Schughart, Klaus ........................................ 81

Steinmann, Eike ......................................... 85

Stradal, Theresia ........................................ 91

van den Heuvel, Joop ................................ 93

Vogel, Jörg ................................................. 95

Wagner-Döbler, Irene .............................. 100

Topic 2 ......................................................... 104

Brinkmann, Melanie ................................ 104

Bruder, Dunja .......................................... 106

Cicin-Sain, Luka ........................................ 109

Guzmán, Carlos A. ................................... 112

Hühn, Jochen .......................................... 119

Jänsch, Lothar ......................................... 124

Kalinke, Ulrich ......................................... 126

Korte, Martin .......................................... 133

Kröger, Andrea ........................................ 135

Medina, Eva ............................................ 137

Meyer-Hermann, Michael....................... 140

Müller, Andreas J. ................................... 143

Pessler Frank C. ....................................... 144

Schmitz, Ingo ........................................... 148

Schraven, Burkhart ................................. 150

Scrima, Andrea ........................................ 153

Sparwasser, Tim ...................................... 154

Strowig, Till ............................................. 161

Hernandez-Vargas, Esteban A................. 163

Weiss, Siegfried ....................................... 165

Wirth, Dagmar ........................................ 171

Topic 3 ........................................................ 174

Bilitewski, Ursula ..................................... 174

Brönstrup, Mark ...................................... 176

Fuhrmann, Gregor .................................. 180

Hartmann, Rolf W. .................................. 181

Hirsch, Anna ............................................ 190

Kalesse, Markus ...................................... 193

Köhnke, Jesko-Alexander ........................ 195

Lehr, Claus-Michael ................................ 197

Luzhetskyy, Andriy .................................. 206

Müller, Rolf ............................................. 211

Stadler, Marc........................................... 225

Titz, Alexander ........................................ 234

Wink, Joachim M..................................... 237

1

Topic 1

Blankenfeldt, Wulf

*Sung K.H., Berkhan G., Hollmann T., Wagner L., *Blankenfeldt W., Hahn F. (2018) Insights into the

Dual Activity of a Bifunctional Dehydratase-Cyclase Domain Angewandte Chemie - International

Edition 57: 343 - 347.

*Bock T., *Luxenburger E., *Hoffmann J., Schütza V., Feiler C., *Müller R., *Blankenfeldt W. (2017)

AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus

xanthus Angewandte Chemie - International Edition 56: 9986 - 9989.

*Bock T., *Volz C., *Hering V., *Scrima A., *Müller R., *Blankenfeldt W. (2017) The AibR-isovaleryl

coenzyme A regulator and its DNA binding site - a model for the regulation of alternative de novo

isovaleryl coenzyme A biosynthesis in Myxococcus xanthus Nucleic Acids Research 45: 2166 - 2178.

*Diederich C., Leypold M., Culka M., Weber H., Breinbauer R., Ullmann G.M., *Blankenfeldt W.

(2017) Mechanisms and Specificity of Phenazine Biosynthesis Protein PhzF Scientific Reports 7: 6272.

Dolan S.K., *Bock T., *Hering V., Owens R.A., Jones G.W., *Blankenfeldt W., Doyle S. (2017)

Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus

fumigatus Open Biology 7: 160292.

Guttenberger N., *Blankenfeldt W., Breinbauer R. (2017) Recent developments in the isolation,

biological function, biosynthesis, and synthesis of phenazine natural products Bioorganic and

Medicinal Chemistry 25: 6149-6166.

Koopmeiners J., *Diederich C., Solarczek J., Voß H., Mayer J., *Blankenfeldt W., Schallmey A. (2017)

HheG, a halohydrin dehalogenase with activity on cyclic epoxides ACS Catalysis 7: 6877 - 6886.

*Lukat P., *Katsuyama Y., *Wenzel S., *Binz T., König C., *Blankenfeldt W., *Brönstrup M., *Müller R.

(2017) Biosynthesis of methyl-proline containing griselimycins, natural products with anti-

tuberculosis activity Chemical Science 8: 7521 - 7527.

*von Tesmar A., *Hoffmann M., *Pippel J., *Fayad A.A., *Dausend-Werner S., Bauer A., *Blankenfeldt

W., Müller R. (2017) Total Biosynthesis of the Pyrrolo[4,2]benzodiazepine Scaffold Tomaymycin on an

In Vitro Reconstituted NRPS System Cell Chemical Biology 24: 1216 - 1227.

*Witzgall F., *Ewert W., *Blankenfeldt W. (2017) Structures of the N-Terminal Domain of PqsA in

Complex with Anthraniloyl- and 6-Fluoroanthraniloyl-AMP: Substrate Activation in Pseudomonas

Quinolone Signal (PQS) Biosynthesis ChemBioChem 18: 2045 - 2055.

*Bock T., *Kasten J., *Müller R., *Blankenfeldt W. (2016) Crystal Structure of the HMG-CoA Synthase

MvaS from the Gram-Negative Bacterium Myxococcus xanthus ChemBioChem 17: 1257 - 1262.

*Bock T., *Müller R., *Blankenfeldt W. (2016) Crystal structure of AibC, a reductase involved in

alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus Acta

Crystallographica Section F: Structural Biology Communications 72: 652 - 658.

2

*Bock T., *Reichelt J., *Müller R., *Blankenfeldt W. (2016) The Structure of LiuC, a 3-Hydroxy-3-

Methylglutaconyl CoA Dehydratase Involved in Isovaleryl-CoA Biosynthesis in Myxococcus xanthus,

Reveals Insights into Specificity and Catalysis ChemBioChem 17: 1658 - 1664.

Füller J.J., Röpke R., *Krausze J., Rennhack K.E., Daniel N.P., *Blankenfeldt W., Schulz S., Jahn D.,

Moser J. (2016) Biosynthesis of violacein, structure and function of L-tryptophan oxidase VioA from

Chromobacterium violaceum Journal of Biological Chemistry 291: 20068 - 20084.

*Zender M., *Witzgall F., Drees S.L., *Weidel E., *Maurer C.K., Fetzner S., *Blankenfeldt W., *Empting

M., *Hartmann R.W. (2016) Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa

Virulence by Discovery of Small Tool Compounds ACS Chemical Biology 11: 1755 - 1763.

Goncharenko K.V., *Vit A., *Blankenfeldt W., Seebeck F.P. (2015) Structure of the sulfoxide synthase

EgtB from the ergothioneine biosynthetic pathway Angewandte Chemie - International Edition 54:

2821 - 2824.

Jiang W., Nowicki C., *Blankenfeldt W (2015) Structural basis for the relaxed substrate selectivity of

Leishmania mexicana broad specificity aminotransferase. Molecular and Biochemical Parasitology

202: 34 – 37.

*Vit A., Mashabela G.T., *Blankenfeldt W., Seebeck F.P. (2015) Structure of the Ergothioneine-

Biosynthesis Amidohydrolase EgtC ChemBioChem 16: 1490 - 1496.

*Vit A., Misson L., *Blankenfeldt W., Seebeck F.P. (2015) Ergothioneine biosynthetic

methyltransferase EgtD reveals the structural basis of aromatic amino acid betaine biosynthesis

ChemBioChem 16: 119 - 125.

*Blankenfeldt W., Parsons J.F. (2014) The structural biology of phenazine biosynthesis Current

Opinion in Structural Biology 29: 26 - 33.

*Vit A., Misson L., *Blankenfeldt W., Seebeck F.P. (2014) Crystallization and preliminary X-ray analysis

of the ergothioneine-biosynthetic methyltransferase EgtD Acta Crystallographica Section F:

Structural Biology and Crystallization Communications 70: 676 - 680.

Publications before start at HZI

Blankenfeldt W. (2013) The Biosynthesis of Phenazines. In: S. Chincholkar, L. Thomashow (eds.).

Microbial Phenazines: Biosynthesis, Agriculture and Health. Springer: 1 - 17. (book chapter)

Feiler C., Fisher A.C., Marrichi M.J., Wright L., Schmidpeter P.A.M., Blankenfeldt W., Pavelka M.,

DeLisa M.P. (2013) Directed evolution of Mycobacterium tuberculosis beta-lactamase reveals

gatekeeper residue that controls drug resistance and catalytic efficiency PLoS ONE 8:73123.

Mavrodi D.V., Parejko J.A., Mavrodi O.V., Kwak Y.S., Weller D.M., Blankenfeldt W., Thomashow L.S.

(2013) Recent insights into the diversity, frequency and ecological roles of phenazines in fluorescent

Pseudomonas spp. Environmental Microbiolology 15: 675 - 686.

Xu N., Ahuja E.G., Janning P., Mavrodi D.V., Thomashow L.S., Blankenfeldt W. (2013) Trapped

3

intermediates in crystals of the FMN-dependent oxidase PhzG provide insight into the final steps of

phenazine biosynthesis Acta Crystallographica Section D: Structural Biology 69: 1403 - 1413.

4

Carlomagno, Teresa

Codutti L., Grimaldi M., *Carlomagno T. (2017) Structure-Based Design of Scaffolds Targeting PDE10A

by INPHARMA-NMR Journal of Chemical Information and Modeling 57: 1488 - 1498.

Karaca E., Rodrigues J.P.G.L.M., Graziadei A., Bonvin A.M.J.J., *Carlomagno T. (2017) M3: An

integrative framework for structure determination of molecular machines Nature Methods 14: 897 -

902.

Lercher L, Danilenko N, *Kirkpatrick J, *Carlomagno T. (2017) Structural characterization of the Asf1-

Rtt109 interaction and its role in histone acetylation Nucleic Acids Research Nucleic Acids Res. 2017

Dec 29. doi: 10.1093/nar/gkx1283.

Scherer S., Wollrab E., Codutti L., *Carlomagno T., Gomes da Costa, S., Volkmer A., Bronja A., Schmitz

O.J., Ott A. (2017) Chemical Analysis of a “Miller-Type” Complex Prebiotic Broth: Part II: Chemical

Diversity, Oxygen and Nitrogen Based Polymers Origins of Life and Evolution of Biospheres 47: 381 -

403.

Graziadei A., Masiewicz P., Lapinaite A., *Carlomagno T. (2016) Archaea box C/D enzymes methylate

two distinct substrate rRNA sequences with different efficiency RNA 22: 764 - 772.

Kozak S., Lercher L., Karanth M.N., Meijers R., *Carlomagno T., Boivin S. (2016) Optimization of

protein samples for NMR using thermal shift assays Journal of Biomolecular NMR 64: 281 - 289.

*Kühne C., *Singer H.M., *Grabisch E., Codutti L., *Carlomagno T., *Scrima A., *Erhardt M. (2016)

RflM mediates target specificity of the RcsCDB phosphorelay system for transcriptional repression of

flagellar synthesis in Salmonella enterica Molecular Microbiology 101: 841 - 855.

Miller T.C.R., Simon B., Rybin V., Grötsch H., Curtet S., Khochbin S., *Carlomagno T., Müller C.W.

(2016) A bromodomain-DNA interaction facilitates acetylation-dependent bivalent nucleosome

recognition by the BET protein BRDT Nature Communications 7: 13855.

Wollrab E., Scherer S., Aubriet F., Carré V., *Carlomagno T., Codutti L., Ott A. (2016) Chemical

Analysis of a “Miller-Type” Complex Prebiotic Broth: Part I: Chemical Diversity, Oxygen and Nitrogen

Based Polymers Origins of Life and Evolution of Biospheres 46: 149–169.

Bowman A., Lercher L., Singh H.R., Zinne D., Timinszky G., *Carlomagno T., Ladurner A.G. (2015) The

histone chaperone sNASP binds a conserved peptide motif within the globular core of histone H3

through its TPR repeats Nucleic Acids Research 44: 3105 - 3117.

Codutti L., Leppek K., Zalesak J., Windeisen V., Masiewicz P., Stoecklin G., *Carlomagno T. (2015) A

Distinct, Sequence-Induced Conformation Is Required for Recognition of the Constitutive Decay

Element RNA by Roquin Structure 23: 1437 - 1447.

Marchanka A., Simon B., Althoff-Ospelt G., *Carlomagno T. (2015) RNA structure determination by

solid-state NMR spectroscopy Nature Communications 6: 7024.

Onila I., Ten Brink T., Fredriksson K., Codutti L., Mazur A., Griesinger C., *Carlomagno T., Exner T.E.

(2015) On-the-Fly Integration of Data from a Spin-Diffusion-Based NMR Experiment into Protein-

Ligand Docking Journal of Chemical Information and Modeling 55: 1971 - 1972.

5

Sikorska J., Codutti L., Skjaerven L., Elshorst B., Saez-Ameneiro R., Angelini A., Monecke P.,

*Carlomagno T. (2015) Identification of new hit scaffolds by INPHARMA-guided virtual screening

MedChemComm 6: 1501 - 1507.

Simon B., Masiewicz P., Ephrussi A., *Carlomagno T. (2015) The structure of the SOLE element of

oskar mRNA RNA 21: 1444 - 1453.


Bock T., Chen W.-H., Ori A., Malik N., Silva-Martin N., Huerta Cepas J., Powell S. T., Kastritis P.,

Smyshlyaev G., Vonkova I., Kirkpatrick J., Doerks T., Nesme L., Basler J., Kos M., Hurt E., Carlomagno

T., Gavin A.-C., Barabas O., Müller C., van Noor V., Beck M., Bork P. (2014) An integrated approach

for genome annotation of the eukaryotic thermophile Chaetomium thermophilum Nucleic Acids

Research 42: 13525-33..

Canales A., Nieto L., Rodríguez-Salarichs J., Sanchez-Murcia P. A., Coderch C., Cortes-Cabrera A.,

Paterson I., Carlomagno T., Gago F., Andreu J. M., Altmann K-H.,Jimenez-Barbero J., Díaz J. F. (2014)

Molecular recognition of Epothilones by microtubules and tubulin dimers revealed by biochemical

and NMR approaches ACS Chemical Biology 9:1033-43.

Findeisen P., Mühlhausen S., Dempewolf S., Hertzog J., Zietlow A., Carlomagno T., Kollmar M. (2014)

Six subgroups and extensive recent duplications characterize the evolution of the eukaryotic tubulin

protein family Genome Biol Evol. 6: 2274-88.

Asami S., Rakwalska-Bange M., Carlomagno T., Reif B. (2013) Protein/RNA interfaces probed by 1H

detected MAS solid-state NMR spectroscopy Angewandte Chemie 52: 2345-2349.

Carlomagno T., Amata I., Codutti L., Falb M., Fohrer J., Simon B. (2013) Structural principles of RNA

catalysis in a 2’-5’ lariat forming ribozyme Journal of the American Chemical Society 135: 4403-4411.

Lapinaite A., Simon B., Skjaerven L., Rakwalska-Bange M., Gabel F., Carlomagno T. (2013) The

structure of the Box C/D enzyme reveals regulation of rRNA methylation Nature 502: 519-52.3

Latek D., Pasznik P., Carlomagno T., Filipek S. (2013) Towards improved quality of GPCR models by

usage of multiple templates and profile-profile comparison PLoS One doi:

10.1371/journal.pone.0056742.

Marchanka A., Simon B., Carlomagno T.(2013) A Suite of solid-state NMR experiments for RNA

intranucleotide resonance assignment in a 21 kDa protein-RNA complex Angewandte Chemie 52:

9996-10001.

Schulte B., John I., Simon B., Brockmann C., Oelmeier S.A., Jahraus B., Kirchgessner H., Riplinger S.,

Carlomagno T., Wabnitz G.H., Samstag Y. (2013) A reducing milieu renders cofilin insensitive to

phosphatidylinositol 4,5-bisphosphate (PIP2) inhibition Journal of Biological Chemistry 288: 29430-

29439.

Skjærven L., Codutti L., Angelini A., Grimaldi M., Latek D., Monecke P., Dreyer M., Carlomagno T.

(2013) Protein-ligand induced-fit docking with NMR guided rescoring Journal of the American

6

Chemical Society 135: 5819-5827.

7

Charpentier, Emmanuelle

*Rhun A.L., Lécrivain A.-L., Reimegard J., Proux-Wéra E., *Broglia L., *Della Beffa C., *Charpentier E.

(2017) Identification of endoribonuclease specific cleavage positions reveals novel targets of RNase III

in Streptococcus pyogenes Nucleic Acids Research 45: 2329 - 2340.

*Fonfara I., *Richter H., * Bratovič M., *Le Rhun A., *Charpentier E. (2016) The CRISPR-associated

DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA Nature 532: 517 - 521.

Labenski V., Suerth J.D., Barczak E., *Heckl D, Levy C., Bernadin O., *Charpentier E., Williams D.A.,

Fehse B., Verhoeyen E., Schambach A. (2016) Alpharetroviral self-inactivating vectors produced by a

superinfection-resistant stable packaging cell line allow genetic modification of primary human T

lymphocytes Biomaterials 97: 97 - 109.

*Le Rhun A., *Beer Y.Y., Reimegård J., Chylinski K., *Charpentier E. (2016) RNA sequencing uncovers

antisense RNAs and novel small RNAs in Streptococcus pyogenes RNA Biology 13: 177 - 195.

Resch U., *Tsatsaronis J.A., *Le Rhun A., Stübiger G., *Rohde M., Kasvandik S., Holzmeister S.,

Tinnefeld P., Nyunt Wai S., *Charpentier E. (2016) A two-component regulatory system impacts

extracellular membrane-derived vesicle production in group A Streptococcus mBio 7: e00207-16.

Sternberg S.H., *Richter H., *Charpentier E., Qimron U. (2016) Adaptation in CRISPR-Cas Systems

Molecular Cell 61: 798 - 808.

Bosley K.S., Botchan M., Bredenoord A.L., Carroll D., Charo R.A., *Charpentier E., Cohen R., Corn J.,

Doudna J., Feng G., Greely H.T., Isasi R., Ji W., Kim J.-S., Knoppers B., Lanphier E., Li J., Lovell-Badge R.,

Martin G.S., Moreno J., Naldini L., Pera M (2015) CRISPR germline engineering - The community

speaks Nature Biotechnology 33: 478 - 486.

*Charpentier E., *Richter H., van der Oost J., White M.F. (2015) Biogenesis pathways of RNA guides in

archaeal and bacterial CRISPR-Cas adaptive immunity FEMS microbiology reviews 39: 428 - 441.

Heckl D., *Charpentier E. (2015) Toward Whole-Transcriptome Editing with CRISPR-Cas9 Molecular

Cell 58: 560 - 562.

Lundgren M., *Charpentier E., Fineran P.C. (2015) CRISPR: Methods and protocols CRISPR: Methods

and Protocols 1 - 366.

Makarova K.S., Wolf Y.I., Alkhnbashi O.S., Costa F., Shah S.A., Saunders S.J., Barrangou R., Brouns

S.J.J., *Charpentier E., Haft D.H., Horvath P., Moineau S., Mojica F.J.M., Terns R.M., Terns M.P., White

M.F., Yakunin A.F., Garrett R.A., Van Der Oost J., (2015) An updated evolutionary classification of

CRISPR-Cas systems Nature Reviews Microbiology 13: 722 - 736.

Plagens A., *Richter H., *Charpentier E., Randau L. (2015) DNA and RNA interference mechanisms by

CRISPR-Cas surveillance complexes FEMS Microbiology Reviews 39: 442 - 463.

*Charpentier E., Marraffini L.A. (2014) Harnessing CRISPR-Cas9 immunity for genetic engineering

8

Current Opinion in Microbiology 19: 114 - 119.

Chylinski K., Makarova K.S., *Charpentier E., Koonin E.V. (2014) Classification and evolution of type II

CRISPR-Cas systems Nucleic Acids Research 42: 6091 - 6105.

Doudna J.A., *Charpentier E. (2014) The new frontier of genome engineering with CRISPR-Cas9

Science 346: 1258096.

*Fonfara I., *Le Rhun A., Chylinski K., Makarova K.S., Lecrivain A.-L., Bzdrenga J., Koonin E.V.,

*Charpentier E. (2014) Phylogeny of Cas9 determines functional exchangeability of dual-RNA and

Cas9 among orthologous type II CRISPR-Cas systems Nucleic Acids Research 42: 2577 - 2590.

Jinek M., Jiang F., Taylor D.W., Sternberg S.H., Kaya E., Ma E., Anders C., Hauer M., Zhou K., Lin S.,

Kaplan M., Iavarone A.T., *Charpentier E., Nogales E., Doudna J.A. (2014) Structures of Cas9

endonucleases reveal RNA-mediated conformational activation Science 343: 1247997.

*Charpentier E., Doudna J.A. (2013) Biotechnology: Rewriting a genome Nature 494: 50 - 51.

Chylinski K., Le Rhun A., *Charpentier E. (2013) The tracrRNA and Cas9 families of type II CRISPR-Cas

immunity systems RNA Biology 10: 726 - 737.

9

Dersch, Petra

Heine W, Beckstette M, Heroven AK, Thiemann S, Heise U, Nuss AM, Pisano F, Strowig T, Dersch P

(2018) Loss of CNFY toxin-induced inflammation drives Yersinia pseudotuberculosis into persistency.

PLoS Pathogens doi: 10.1371/journal.ppat.1006858.

*Kusmierek M., *Dersch P. (2018) Regulation of host-pathogen interactions via the post-

transcriptional Csr/Rsm system Current Opinion in Microbiology 41: 58 - 67.

*Dersch P., Khan M.A., *Mühlen S., Görke B. (2017) Roles of regulatory RNAs for antibiotic resistance

in bacteria and their potential value as novel drug targets Frontiers in Microbiology 8: 803.

*Heroven A.K., *Nuss A.M., *Dersch P. (2017) RNA-based mechanisms of virulence control in

Enterobacteriaceae RNA Biology 14: 471 - 487.

*Nuss A.M., *Beckstette M., *Pimenova M., *Schmühl C., *Opitz W., *Pisano F., *Heroven A.K.,

*Dersch P. (2017) Tissue dual RNA-seq allows fast discovery of infection-specific functions and

riboregulators shaping host-pathogen transcriptomes Proceedings of the National Academy of

Sciences of the United States of America 114: E791 - E800.

*Nuss A.M., *Heroven A.K., *Dersch P. (2017) RNA Regulators: Formidable Modulators of Yersinia

Virulence Trends in Microbiology 25: 19 - 34.

*Pasztoi M, *Bonifacius A, *Pezoldt J, *Kulkarni D, *Niemz J, Yang J, *Teich R, *Hajek J, *Pisano F,

*Rohde M, *Dersch P, *Huehn J. (2017) Yersinia pseudotuberculosis supports Th17 differentiation

and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling

Cellular and Molecular Life Sciences 74: 2839 - 2850.

*Pezoldt J., *Pisano F., *Heine W., *Pasztoi M., *Rosenheinrich M., *Nuss A.M., *Pils M.C., Prinz I.,

Förster R., *Huehn J., *Dersch P. (2017) Impact of CCR7 on T-Cell Response and Susceptibility to

Yersinia pseudotuberculosis Infection Journal of Infectious Diseases 216: 752 - 760.

Solbach P., *Dersch P., Bachmann O. (2017) Individualized treatment strategies for Clostridium

difficile infections [Individuelle Therapiestrategien bei Clostridium-difficile-Infektionen] Internist 58:

675 - 681.

Avican U., *Beckstette M., *Heroven A.K., Lavander M., *Dersch P., Forsberg Å. (2016) Transcriptomic

and phenotypic analysis reveals new functions for the tat pathway in Yersinia pseudotuberculosis

Journal of Bacteriology 198: 2876 - 2886.

Drechsler-Hake D., Alamir H., Günter M., Wagner S., Schütz M., Bohn E., Schenke-Layland K., *Pisano

F., *Dersch P., Autenrieth I.B., Autenrieth S.E. (2016) Mononuclear phagocytes contribute to

intestinal invasion and dissemination of Yersinia enterocolitica International Journal of Medical

Microbiology 306: 357 - 366.

*Heroven A.K., *Dersch P. (2016) Metabolic adaptation of human pathogenic yersiniae in Host -

Pathogen Interaction: Microbial Metabolism, Pathogenicity and Antiinfectives (eds G. Unden, E.

Thines and A. Schüffler), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi:

10.1002/9783527682386.ch1

10

*Maurer C.K., *Fruth M., *Empting M., Avrutina O., *Hoßmann J., *Nadmid S., Gorges J., *Herrmann

J., Kazmaier U., *Dersch P., *Müller R., *Hartmann R.W. (2016) Discovery of the first small-molecule

CsrA-RNA interaction inhibitors using biophysical screening technologies Future Medicinal Chemistry

8: 931 - 947.

*Menina S., *Labouta H.I., *Geyer R., *Krause T., *Gordon S., *Dersch P., *Lehr C.-M. (2016) Invasin-

functionalized liposome nanocarriers improve the intracellular delivery of anti-infective drugs RSC

Advances 6: 41622 - 41629.

*Mühlen S., *Dersch P. (2016) Anti-virulence strategies to target bacterial infections Current Topics

in Microbiology and Immunology 398: 147 - 183.

*Nuss A.M., *Schuster F., Roselius L., Klein J., Bücker R., *Herbst K., *Heroven A.K., *Pisano F.,

Wittmann C., Münch R., Müller J., Jahn D., *Dersch P. (2016) A Precise Temperature-Responsive

Bistable Switch Controlling Yersinia Virulence PLoS Pathogens 12: e1006091.

Righetti F., *Nuss A.M., Twittenhoff C., Beele S., Urban K., Will S., Bernhart S.H., Stadler P.F., *Dersch

P., Narberhaus F. (2016) Temperature-responsive in vitro RNA structurome of Yersinia

pseudotuberculosis Proceedings of the National Academy of Sciences of the United States of

America 113: 7237 - 7242.

Wang H., Avican K., Fahlgren A., Erttmann S.F., *Nuss A.M., *Dersch P., Fallman M., Edgren T., Wolf-

Watz H. (2016) Increased plasmid copy number is essential for Yersinia T3SS function and virulence

Science 353: 492 - 495.

Zeitouni N.E., *Dersch P., Naim H.Y., Von Köckritz-Blickwede M. (2016) Hypoxia decreases invasin-

mediated Yersinia enterocolitica internalization into Caco-2 Cells PLoS ONE 11: e0146103 .

Avican K., Fahlgren A., Huss M., *Heroven A.K., *Beckstette M., *Dersch P., Fallman M. (2015)

Reprogramming of Yersinia from virulent to persistent mode revealed by complex in vivo RNA-seq

analysis PLoS Pathogens 11: 1 - 28.

*Erhardt M., *Dersch P. (2015) Regulatory principles governing Salmonella and Yersinia virulence

Frontiers in Microbiology 6: 949.

*Labouta H.I., *Menina S., *Kochut A., *Gordon S., *Geyer R., *Dersch P., *Lehr C.M. (2015)

Bacteriomimetic invasin-functionalized nanocarriers for intracellular delivery Journal of Controlled

Release 220: 414 - 424.

Möllerherm H., Neumann A., Schilcher K., Blodkamp S., Zeitouni N.E., *Dersch P., Lüthje P., Naim

H.Y., Zinkernagel A.S., von Köckritz-Blickwede M. (2015) Yersinia enterocolitica-mediated degradation

of neutrophil extracellular traps (NETs) FEMS Microbiology Letters 362: fnv192.

*Nuss A.M., *Heroven A.K., *Waldmann B., Reinkensmeier J., *Jarek M., *Beckstette M., *Dersch P.

(2015) Transcriptomic profiling of Yersinia pseudotuberculosis reveals reprogramming of the Crp

regulon by temperature and uncovers Crp as a master regulator of small RNAs PLoS Genetics 11:

e1005087.

11

*Rosenheinrich M., *Heine W., *Schmühl C.M., *Pisano F., *Dersch P. (2015) Natural killer cells

mediate protection against Yersinia pseudotuberculosis in the mesenteric lymph nodes PLoS ONE 10:

e0136290.

Schwiesow L., Lam H., *Dersch P., Auerbuch V. (2015) Yersinia type III secretion system master

regulator LcrF Journal of Bacteriology 198: 604 - 614.

Bucker R., *Heroven A.K., Becker J., *Dersch P., Wittmann C. (2014) The pyruvate-tricarboxylic acid

cycle node: A focal point of virulence control in the enteric pathogen Yersinia pseudotuberculosis

Journal of Biological Chemistry 289: 30114 - 30132.

Heroven A.K., *Dersch P. (2014) Coregulation of host-adapted metabolism and virulence by

pathogenic yersiniae Frontiers in Cellular and Infection Microbiology 4: 146.

*Nuss A.M., *Schuster F., *Heroven A.K., *Heine W., *Pisano F., *Dersch P. (2014) A direct link

between the global regulator PhoP and the Csr regulon in Y. pseudotuberculosis through the small

regulatory RNA CsrC RNA Biology 11: May 2014.

*Pisano F., *Heine W., *Rosenheinrich M., *Schweer J., *Nuss A.M., *Dersch P. (2014) Influence of

PhoP and intra-species variations on virulence of Yersinia pseudotuberculosis during the natural oral

infection route PLoS ONE 9: e103541.

*Schaake J., Drees A., Gruning P., *Uliczka F., *Pisano F., *Thiermann T., von Altrock A., Seehusen F.,

Valentin-Weigand P., *Dersch P. (2014) Essential role of invasin for colonization and persistence of

Yersinia enterocolitica in its natural reservoir host, the pig Infection and Immunity 82: 960 - 969.

Valentin-Weigand P., Heesemann J., *Dersch P. (2014) Unique virulence properties of Yersinia

enterocolitica O:3-An emerging zoonotic pathogen using pigs as preferred reservoir host

International Journal of Medical Microbiology 304: 824 - 834.

*Kochut A., *Dersch P. (2013) Bacterial invasion factors: Tools for crossing biological barriers and

drug delivery? European Journal of Pharmaceutics and Biopharmaceutics 84: 242 - 250.

*Schaake J., *Kronshage M., *Uliczka F., *Rohde M., *Knuuti T., Strauch E., Fruth A., *Wos-Oxley M.,

*Dersch P. (2013) Human and animal isolates of Yersinia enterocolitica show significant serotype-

specific colonization and host-specific immune defense properties Infection and Immunity 81: 4013 -

4025.

*Schweer J., *Kulkarni D., *Kochut A., *Pezoldt *J., Pisano F., *Pils M.C., Genth H., *Huehn J., *Dersch

P. (2013) The cytotoxic necrotizing factor of Yersinia pseudotuberculosis (CNFY) enhances

inflammation and Yop delivery during infection by activation of Rho GTPases PLoS Pathogens 9:

e1003746.

*Steinmann R., *Dersch P. (2013) Thermosensing to adjust bacterial virulence in a fluctuating

environment Future Microbiology 8: 85 - 105.

12

Engelmann, Susanne

Boedeker C., Schüler M., Reintjes G., Jeske O., Van Teeseling M.C.F., Jogler M., Rast P., Borchert D.,

Devos D.P., *Kucklick M., Schaffer M., Kolter R., Van Niftrik L., *Engelmann S., Amann R., *Rohde M.,

Engelhardt H., Jogler C. (2017) Determining the bacterial cell biology of Planctomycetes Nature

Communications 8: 14853.

Stentzel S., Teufelberger A., Nordengrün M., Kolata J., Schmidt F., van Crombruggen K., Michalik S.,

Kumpfmüller J., Tischer S., Schweder T., Hecker M., *Engelmann S., Völker U., Krysko O., Bachert C.,

Bröker B.M. (2017) Staphylococcal serine protease-like proteins are pacemakers of allergic airway

reactions to Staphylococcus aureus Journal of Allergy and Clinical Immunology 139: 492 - 500.

*Engelmann S., Fuchs S., Hecker M. (2016) Physiological proteomics of S. aureus – from the protein

inventory to stress physiology and in vivo adaptation In: G. A. Somerville (ed) Staphylococcus:

Genetics and Physiology. Caister Academic Press. Chapter 7, pp119-132.

Selle M., Hertlein T., Oesterreich B., Klemm T., Kloppot P., Müller E., Ehricht R., Stentzel S., Bröker

B.M., *Engelmann S., Ohlsen K. (2016) Global antibody response to Staphylococcus aureus live-cell

vaccination Scientific Reports 6: 24754.

Vu C.H., Kolata J., Stentzel S., Beyer A., Gesell Salazar M., Steil L., Pané-Farré J., Rühmling V.,

*Engelmann S., Götz F., van Dijl J.M., Hecker M., Mäder U., Schmidt F., Völker U., Bröker B.M. (2016)

Adaptive immune response to lipoproteins of Staphylococcus aureus in healthy subjects Proteomics

16: 2667 - 2677.

Zühlke D., Dörries K., Bernhardt J., Maaß S., Muntel J., Liebscher V., Pané-Farré J., Riedel K., Lalk M.,

Völker U., *Engelmann S., Becher D., Fuchs S., Hecker M. (2016) Costs of life-Dynamics of the protein

inventory of Staphylococcus aureus during anaerobiosis Scientific Reports 6: 28172.

Bauer I., Gunther J., Wheeler T.T., *Engelmann S., Seyfert H.-M. (2015) Extracellular milieu grossly

alters pathogen-specific immune response of mammary epithelial cells BMC Veterinary Research 11:

172.

Kloppot P., Selle M., Kohler C., Stentzel S., Fuchs S., Liebscher V., Müller E., Kale D., Ohlsen K., Bröker

B.M., Zipfel P.F., Kahl B.C., Ehricht R., Hecker M., *Engelmann S. (2015) Microarray-based

identification of human antibodies against Staphylococcus aureus antigens Proteomics - Clinical

Applications 9: 1003 - 1011.

*Neumann Y., Ohlsen K., Donat S., *Engelmann S., Kusch H., Albrecht D., Cartron M., Hurd A., Foster

S.J. (2015) The effect of skin fatty acids on Staphylococcus aureus Archives of Microbiology 197: 245

- 267.

Stentzel S., Sundaramoorthy N., Michalik S., Nordengrün M., Schulz S., Kolata J., Kloppot P.,

*Engelmann S., Steil L., Hecker M., Schmidt F., Völker U., Roghmann M.-C., Bröker B.M. (2015)

Specific serum IgG at diagnosis of Staphylococcus aureus bloodstream invasion is correlated with

disease progression Journal of Proteomics 128: 1 - 7.

Halbedel S., Reiss S., Hahn B., Albrecht D., Mannala G.K., Chakraborty T., Hain T., *Engelmann S.,

Flieger A. (2014) A systematic proteomic analysis of Listeria monocytogenes house-keeping protein

13

secretion systems Molecular and Cellular Proteomics 13: 3063 - 3081.

Kusch H., *Engelmann S. (2014) Secrets of the secretome in Staphylococcus aureus International

Journal of Medical Microbiology 304: 133 - 141.

Müller M., Reiss S., Schlüter R., Mäder U., Beyer A., Reiss W., Marles-Wright J., Lewis R.J., Pförtner H.,

Völker U., Riedel K., Hecker M., *Engelmann S., Pané-Farré J. (2014) Deletion of membrane-

associated Asp23 leads to upregulation of cell wall stress genes in Staphylococcus aureus Molecular



Michaux C., Hartke A., Martini C., Reiss S., Albrecht D., Budin-Verneuil A., Sanguinetti M., Engelmann

S., Hain T., Vernieul N., Giard J.C. (2014) Involvement of Enterococcus faecalis sRNAs in the stress

response and virulence. Infection and Immunity 82: 3599 – 3611

Dangel A., Ackermann N., Abdel-Hadi O., Maier R., Önder K., Francoise P., Benz R., Mueller C.W.,

Pané-Farré J., Engelmann S., Schrenzel J., Heesemann J., Lindermayr C. (2013) A de-novo designed

antimicrobial peptide with activity against multiresistant Staphylococcus aureus acting on RsbW

kinase. FASEB Journal 27: 4476 - 4488.

Fuchs S., Zühlke D., Pané-Farré J., Kusch H., Wolf C., Reiß S., Binh L.T.N., Albrecht D., Riedel K., Hecker

M., Engelmann S. (2013) Aureolib – a proteome signature library: Towards an understanding of

Staphylococcus aureus pathophysiology. PlosOne 8:e70669.

14

Erhardt, Marc

*Felgner S., *Kocijancic D., *Frahm M., *Heise U., *Rohde M., Zimmermann K., Falk C., *Erhardt M.,

*Weiss S. (2018) Engineered Salmonella enterica serovar Typhimurium overcomes limitations of anti-

bacterial immunity in bacteria-mediated tumor therapy OncoImmunology 7: e1382791.

Ward E., *Renault T.T., Kim E.A., *Erhardt M., Hughes K.T., Blair D.F. (2018) Type-III secretion pore

formed by flagellar protein FliP Molecular Microbiology 107: 94 - 103.

*Erhardt M, Wheatley P, Kim EA, Hirano T, Zhang Y, Sarkar MK, Hughes KT, Blair DF. (2017)

Mechanism of type-III protein secretion: Regulation of FlhA conformation by a functionally critical

charged-residue cluster Molecular Microbiology 104: 234 - 249.

*Erhardt M. (2017) Energy requirements for protein secretion via the flagellar type III secretion

system Methods in Molecular Biology 1615: 449 - 457.

*Erhardt M. (2017) Fluorescent microscopy techniques to study hook length control and flagella

formation Methods in Molecular Biology 1593: 37 - 46.

*Fabiani F.D., *Renault T.T., Peters B., Dietsche T., Gálvez E.J.C., *Guse A., *Freier K., Charpentier E.,

*Strowig T., Franz-Wachtel M., Macek B., Wagner S., Hensel M., *Erhardt M. (2017) A flagellum-

specific chaperone facilitates assembly of the core type III export apparatus of the bacterial flagellum

PLoS Biology 15: e2002267.

*Felgner S., *Pawar V., *Kocijancic D., *Erhardt M., Weiss S. (2017) Tumour-targeting bacteria-based

cancer therapies for increased specificity and improved outcome Microbial Biotechnology Sep.17:

1074 - 1078.

*Horstmann J.A., *Zschieschang E., Truschel T., *de Diego J., *Lunelli M., *Rohde M., May T.,

*Strowig T., *Stradal T., *Kolbe M., *Erhardt M. (2017) Flagellin phase-dependent swimming on

epithelial cell surfaces contributes to productive Salmonella gut colonisation Cellular Microbiology

19: e12739.

*Kocijancic D., *Felgner S., *Schauer T., *Frahm M., *Heise U., Zimmermann K., *Erhardt M., *Weiss

S. (2017) Local application of bacteria improves safety of Salmonella-mediated tumor therapy and

retains advantages of systemic infection Oncotarget 8: 49988 - 50001.

Paradis G., Chevance F.F.V., Liou W., *Renault T.T., Hughes K.T., Rainville S., *Erhardt M. (2017)

Variability in bacterial flagella re-growth patterns after breakage Scientific Reports 7: 1282.

*Renault T.T., Abraham A.O., Bergmiller T., Paradis G., Rainville S., Charpentier E., Guet C.C., Tu Y.,

Namba K., Keener J.P., Minamino T., *Erhardt M. (2017) Bacterial flagella grow through an injection-

diffusion mechanism eLife 6: e23136.

*Thiemann S., *Smit N., *Roy U., *Lesker T.R., *Gálvez E.J.C., *Helmecke J., Basic M., Bleich A.,

Goodman A.L., *Kalinke U., Flavell R.A., *Erhardt M., *Strowig T. (2017) Enhancement of IFNγ

Production by Distinct Commensals Ameliorates Salmonella-Induced Disease Cell Host and Microbe

21: 682 - 694.e5.

15

Barlag B., Beutel O., Janning D., Czarniak F., Richter C.P., Kommnick C., Göser V., Kurre R., *Fabiani F.,

*Erhardt M., Piehler J., Hensel M. (2016) Single molecule super-resolution imaging of proteins in

living Salmonella enterica using self-labelling enzymes Scientific Reports 6: 31601.

*Erhardt M. (2016) Strategies to block bacterial pathogenesis by interference with motility and

chemotaxis Current Topics in Microbiology and Immunology 398: 185 - 205.

*Felgner S., *Frahm M., *Kocijancic D., *Rohde M., *Eckweiler D., *Bielecka A., Bueno E., Cava F.,

*Abraham W.-R., Curtiss R., III, *Häussler S., *Erhardt M., *Weiss S. (2016) Aroa-deficient Salmonella

enterica serovar Typhimurium is more than a metabolically attenuated mutant mBio 7: e01220-16.

Felgner S., *Kocijancic D., *Frahm M., Curtiss R., 3rd, *Erhardt M., *Weiss S. (2016) Optimizing

Salmonella enterica serovar Typhimurium for bacteria-mediated tumor therapy Gut microbes 7: 171

- 177.

*Kühne C., *Singer H.M., *Grabisch E., Codutti L., *Carlomagno T., *Scrima A., *Erhardt M. (2016)

RflM mediates target specificity of the RcsCDB phosphorelay system for transcriptional repression of

flagellar synthesis in Salmonella enterica Molecular Microbiology 101: 841 - 855.

*Deditius J.A., *Felgner S., *Spöring I., *Kühne C., *Frahm M., *Rohde M., *Weiß S., *Erhardt M.

(2015) Characterization of novel factors involved in swimming and swarming motility in Salmonella

enterica serovar typhimurium PLoS ONE 10: e0135351.

*Erhardt M., *Dersch P. (2015) Regulatory principles governing Salmonella and Yersinia virulence


*Frahm M., *Felgner S., *Kocijancic D., *Rohde M., Hensel M., Curtiss I.R., *Erhardt M., *Weiss S.

(2015) Efficiency of conditionally attenuated Salmonella enterica serovar typhimurium in bacterium-

mediated tumor therapy mBio 6: 1 - 11.

*Erhardt M., Mertens M.E., *Fabiani F.D., Hughes K.T. (2014) ATPase-Independent Type-III Protein

Secretion in Salmonella enterica PLoS Genetics 10: e1004800.

*Singer H.M., *Erhardt M. (2014) Regulation, Aufbau und Funktion einer bakteriellen Nanomaschine

BioSpektrum 20: 500 - 502.

Singer H.M., *Erhardt M., Hughes K.T. (2014) Comparative analysis of the secretion capability of early

and late flagellar type III secretion substrates Molecular Microbiology 93: 505 - 520.

Singer H.M., *Kuhne C., *Deditius J.A., Hughes K.T., *Erhardt M. (2014) The Salmonella Spi1 virulence

regulatory protein HilD directly activates transcription of the flagellar master operon flhDC Journal of

Bacteriology 196: 1448 - 1457.

Singer H.M., *Erhardt M., Hughes K.T. (2013) RflM functions as a transcriptional repressor in the

autogenous control of the Salmonella flagellar master operon flhDC Journal of Bacteriology 195:

4274 - 4282.

16

Geffers, Robert

Walter C., Pozzorini C., Reinhardt K., *Geffers R., Xu Z., Reinhardt D., Neuhoff N., Hanenberg H.

(2018) Single-cell whole exome and targeted sequencing in NPM1/FLT3 positive pediatric acute

myeloid leukemia Pediatric Blood and Cancer 65: e26848.

Wang J., Bogdanova N., Schürmann P., Park-Simon T.-W., *Geffers R., Dörk T. (2018) Assessment of a

FBXW8 frameshift mutation, c.1312_1313delGT, in breast cancer patients and controls from Central

Europe Cancer Genetics 220: 38 - 43.

Atschekzei F., Dörk T., Schürmann P., *Geffers R., Witte T., Schmidt R.E. (2017) Limited role of

interferon-kappa (IFNK) truncating mutations in common variable immunodeficiency Cytokine 96: 71

- 74.

Bernhardt A., Fehr A., Brandt S., Jerchel S., Ballhause T.M., Philipsen L., Stolze S., *Geffers R., Weng

H., Fischer K.-D., Isermann B., Brunner-Weinzierl M.C., Batra A., Siegmund B., Zhu C., Lindquist J.A.,

Mertens P.R. (2017) Inflammatory cell infiltration and resolution of kidney inflammation is

orchestrated by the cold-shock protein Y-box binding protein-1 Kidney International.

doi: 10.1016/j.kint.2017.03.035

Bletz MC, Perl RG, Bobowski BT, Japke LM, Tebbe CC, Dohrmann AB, Bhuju S, *Geffers R, Jarek M,

Vences M. (2017) Amphibian skin microbiota exhibits temporal variation in community structure but

stability of predicted Bd-inhibitory function ISME Journal 11: 1521 - 1534.

Chaturvedi A, Araujo Cruz MM, Jyotsana N, Sharma A, Goparaju R, Schwarzer A, Görlich K,

Schottmann R, Struys EA, Jansen EE, Rohde C, Müller-Tidow C, *Geffers R, Göhring G, Ganser A, Thol

F, Heuser M. (2017) Enantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-

hydroxyglutarate Leukemia 30: 1708 - 1715.

Chaturvedi A, Herbst L, Pusch S, Klett L, Goparaju R, Stichel D, Kaulfuss S, Panknin O, Zimmermann K,

Toschi L, Neuhaus R, Haegebarth A, Rehwinkel H, Hess-Stumpp H, Bauser M, Bochtler T, Struys EA,

Sharma A, Bakkali A, *Geffers R, Araujo-Cruz MM, Thol F (2017) Pan-mutant-IDH1 inhibitor

BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo Leukemia

31: 2020 - 2028.Chen S., Nagel S., Schneider B., Dai H., *Geffers R., Kaufmann M., Meyer C.,

Pommerenke C., Thress K.S., Li J., Quentmeier H., Drexler H.G., MacLeod R.A.F. (2017) A new ETV6-

NTRK3 cell line model reveals MALAT1 as a novel therapeutic target - a short report Cellular

Oncology 41(1): 93 - 101.

Ehrentraut S., Nagel S., Pommerenke C., Dirks W.G., Quentmeier H., Kaufmann M., Meyer C.,

Zaborski M., *Geffers R., Fujiwara H., Drexler H.G., MacLeod R.A.F. (2017) Peripheral T-cell lymphoma

cell line T8ML-1 highlights conspicuous targeting of PVRL2 by t(14;19)(q11.2;q13.3) Haematologica

102: 356 - 359.

*Garg G, *Nikolouli E, Hardtke-Wolenski M, Toker A, Ohkura N, Beckstette M, Miyao T, *Geffers R,

*Floess S, Gerdes N, Lutgens E, Osterloh A, Hori S, Sakaguchi S, Jaeckel E, *Huehn J. (2017) Unique

properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific

regulatory T cells Oncotarget 8: 35542 - 35557.

*Hatesuer B., *Hoang H.T.T., *Riese P., *Trittel S., *Gerhauser I., *Elbahesh H., *Geffers R., *Wilk E.,

17

*Schughart K. (2017) Deletion of Irf3 and Irf7 Genes in Mice Results in Altered Interferon Pathway

Activation and Granulocyte-Dominated Inflammatory Responses to Influenza A Infection Journal of

Innate Immunity 9: 145 - 161.

Heuser M., Gabdoulline R., Löffeld P., Dobbernack V., Kreimeyer H., Pankratz M., Flintrop M., Liebich

A., Klesse S., Panagiota V., Stadler M., Wichmann M., Shahswar R., Platzbecker U., Thiede C.,

Schroeder T., Kobbe G., *Geffers R., Schlegelberger B., Göhring G, Kreipe HH, Germing U, Ganser A,

Kröger N, Koenecke C, Thol F (2017) Individual outcome prediction for myelodysplastic syndrome

(MDS) and secondary acute myeloid leukemia from MDS after allogeneic hematopoietic cell

transplantation Annals of Hematology 96: 1361 - 1372.

Kar S., Bali K.K., Baisantry A., *Geffers R., Samii A., Bertalanffy H. (2017) Genome-Wide Sequencing

Reveals MicroRNAs Downregulated in Cerebral Cavernous Malformations Journal of Molecular

Neuroscience 61: 178 - 188.

*Khera T., *Todt D., Vercauteren K., McClure C.P., Verhoye L., Farhoudi A., *Bhuju S., *Geffers R.,

Baumert T.F., *Steinmann E., Meuleman P., Meuleman P., Baumert T.F., Baumert T.F.,

*Pietschmann T., *Brown R.J.P. (2017) Tracking HCV protease population diversity during

transmission and susceptibility of founder populations to antiviral therapy Antiviral Research 139:

129 - 137.

Kleist S, Ulbrich M, Bill N, Schmidt-Hohagen K, *Geffers R, Schomburg D. (2017) Dealing with salinity

extremes and nitrogen limitation - an unexpected strategy of the marine bacterium Dinoroseobacter

shibae Environmental Microbiology 19: 894 - 908.

*Nikolouli E., Hardtke-Wolenski M., Hapke M., *Beckstette M., *Geffers R., *Floess S., Jaeckel E.,

*Huehn J. (2017) Alloantigen-induced regulatory t cells generated in presence of vitamin c display

enhanced stability of foxp3 expression and promote skin allograft acceptance Frontiers in

Immunology 8: 748.

Noyan F., Zimmermann K., Hardtke-Wolenski M., Knoefel A., Schulde E., *Geffers R., Hust M., *Huehn

J., Galla M., Morgan M., Jokuszies A., Manns M.P., Jaeckel E. (2017) Prevention of Allograft Rejection

by Use of Regulatory T Cells With an MHC-Specific Chimeric Antigen Receptor American Journal of

Transplantation 17: 917 - 930.

Pietrucha B., Heropolitanska-Pliszka E., *Geffers R., Enßen J., Wieland B., Bogdanova N.V., Dörk T.

(2017) Clinical and biological manifestation of RNF168 deficiency in two polish siblings Frontiers in

Immunology 8: 1683.

Radmanesh H., Spethmann T., Enßen J., Schürmann P., *Bhuju S., *Geffers R., Antonenkova N.,

Khusnutdinova E., Sadr-Nabavi A., Shandiz F.H., Park-Simon T.-W., Hillemanns P., Christiansen H.,

Bogdanova N., Dörk T. (2017) Assessment of an APOBEC3B truncating mutation, c.783delG, in

patients with breast cancer Breast Cancer Research and Treatment 162: 31 - 37.

Ravens S, Schultze-Florey C, Raha S, Sandrock I, Drenker M, Oberdörfer L, Reinhardt A, Ravens I, Beck

M, *Geffers R, von Kaisenberg C, Heuser M, Thol F, Ganser A, Förster R, Koenecke C, Prinz I. (2017)

Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal

expansion in response to viral infection Nature Immunology 18: 393 - 401.

18

Sabino-Pinto J, Galán P, Rodríguez S, Bletz MC, Bhuju S, *Geffers R, Jarek M, Vences M. (2017)

Temporal changes in cutaneous bacterial communities of terrestrial- and aquatic- phase newts

(Amphibia) Environmental Microbiology 19: 3025 - 3038.

Sanchez E., Bletz M.C., Duntsch L., *Bhuju S., *Geffers R., *Jarek M., Dohrmann A.B., Tebbe C.C.,

Steinfartz S., Vences M. (2017) Cutaneous Bacterial Communities of a Poisonous Salamander: a

Perspective from Life Stages, Body Parts and Environmental Conditions Microbial Ecology 73: 455 -

465.

Schneefeld M., Busche T., *Geffers R., Kalinowski J., Bange F.-C. (2017) The transcriptional regulator

LysG (Rv1985c) of Mycobacterium tuberculosis activates lysE (Rv1986) in a lysine-dependent manner

PLoS ONE 12: e0186505.

Singh AK, Rooge SB, Varshney A, Vasudevan M, Bhardwaj A, Venugopal SK, Trehanpati N, Kumar M,

*Geffers R, Kumar V, Sarin SK. (2017) Global micro RNA expression profiling in the liver biopsies of

Hepatitis B Virus infected patients suggests specific miRNA signatures for viral persistence and

hepatocellular injury Hepatology Hepatology. 2017 Nov 30. doi: 10.1002/hep.29690.

Tang BM, Shojaei M, Parnell GP, Huang S, Nalos M, Teoh S, O'Connor K, Schibeci S, Phu AL, Kumar A,

Ho J, Meyers AFA, Keynan Y, Ball T, Pisipati A, Kumar A, Moore E, Eisen D, Lai K, Gillett M, *Geffers R,

Luo H, et al. (2017) A novel immune biomarker IFI27 discriminates between influenza and bacteria in

patients with suspected respiratory infection European Respiratory Journal 49: pii: 1602098.

Westendorf AM, Skibbe K, Adamczyk A, Buer J, *Geffers R, Hansen W, Pastille E, Jendrossek V. (2017)

Hypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting

Treg Activity Cellular Physiology and Biochemistry 41: 1271 - 1284.

Bletz M.C., Goedbloed D.J., Sanchez E., Reinhardt T., Tebbe C.C., *Bhuju S., *Geffers R., *Jarek M.,

Vences M., Steinfartz S. (2016) Amphibian gut microbiota shifts differentially in community structure

but converges on habitat-specific predicted functions Nature Communications 7: 13699.

de Araujo L.S., *Vaas L.A.I., Ribeiro-Alves M., *Geffers R., Mello F.C.Q., de Almeida A.S., Moreira

A.S.R., Kritski A.L., Lapa e Silva J.R., Moraes M.O., *Pessler F., Saad M.H.F. (2016) Transcriptomic

biomarkers for tuberculosis: Evaluation of DOCK9, EPHA4, and NPC2 mRNA expression in peripheral

blood Frontiers in Microbiology 7: 1586.

Ehrentraut S., Schneider B., Nagel S., Pommerenke C., Quentmeier H., *Geffers R, Feist M., Kaufmann

M., Meyer C, Kadin M.E., Drexler H.G., MacLeod R.A. (2016) Th17 cytokine differentiation and loss of

plasticity after SOCS1 inactivation in a cutaneous T-cell lymphoma Oncotarget 7: 34201 - 34216.

Ehsani E., *Barrantes I., Vandermaesen J., *Geffers R., Jarek M., Boon N., Springael D., *Pieper D.H.,

Vilchez-Vargas R. (2016) Draft genome sequence of Aeromonas sp. strain EERV15 Genome

Announcements 4: e00811-16.

Endig J., Buitrago-Molina L.E., Marhenke S., Reisinger F., Saborowski A., Schütt J., Limbourg F.,

Könecke C., Schreder A., Michael A., Misslitz A.C., Healy M.E., *Geffers R., Clavel T., Haller D., Unger

K., Finegold M., Weber A., Manns M.P., Longerich T., (2016) Dual Role of the Adaptive Immune

19

System in Liver Injury and Hepatocellular Carcinoma Development Cancer Cell 30: 308 - 323.

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*Titz A. (2016) The virulence factor LecB varies in clinical isolates: Consequences for ligand binding

and drug discovery Chemical Science 7: 4990 - 5001.

Tata M., Wolfinger M.T., Amman F., Roschanski N., *Dötsch A., Sonnleitner E., *Häussler S., Bläsi U.

(2016) RNAseq based transcriptional profiling of Pseudomonas aeruginosa PA14 after shortand long-

term anoxic cultivation in synthetic cystic fibrosis sputum medium PLoS ONE 11: e0147811.





*Bielecki P., *Jensen V., *Schulze W., *Godeke J., *Strehmel J., *Eckweiler D., *Nicolai T., *Bielecka

A., Wille T., Gerlach R.G., *Häussler S. (2015) Cross talk between the response regulators PhoB and

TctD allows for the integration of diverse environmental signals in Pseudomonas aeruginosa Nucleic

Acids Research 43: 6413 - 6425.

*Blanka A., *Duvel J.,* Dotsch A., Klinkert B., *Abraham W.-R., Kaever V., *Ritter C., Narberhaus F.,

*Häussler S. (2015) Constitutive production of c-di-GMP is associated with mutations in a variant of

Pseudomonas aeruginosa with altered membrane composition Science Signaling 8: ra36 - ra36.

*Bruchmann S., *Muthukumarasamy U., *Pohl S., *Preusse M., *Bielecka A., *Nicolai T., Hamann I.,

Hillert R., Kola A., Gastmeier P., *Eckweiler D., *Häussler S. (2015) Deep transcriptome profiling of

clinical Klebsiella pneumoniae isolates reveals strain and sequence type-specific adaptation

Environmental Microbiology 17: 4690 - 4710.

*Dotsch A., *Schniederjans M., *Khaledi A., *Hornischer K., *Schulz S., *Bielecka A., *Eckweiler D.,

*Pohl S., *Häussler S. (2015) The Pseudomonas aeruginosa transcriptional landscape is shaped by

environmental heterogeneity and genetic variation mBio 6: e00749-15.

*Düvel J., *Bense S., Möller S., Bertinetti D., Schwede F., *Morr M., *Eckweiler D., Genieser H.G.,

*Jänsch L., Herberg F.W., *Frank R., *Häussler S. (2015) Application of synthetic peptide arrays to

uncover cyclic di-GMP binding motifs Journal of Bacteriology 198: 138 - 146.

28

*Häussler S., *Blanka A., VanHook A.M. (2015) Science signaling podcast: 14 April 2015 Science

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*Pawar V., *Komor U., *Kasnitz N., *Bielecki P., *Pils M.C., Gocht B., Moter A., *Rohde M., *Weiss S.,

*Häussler S. (2015) In vivo efficacy of antimicrobials against biofilm-producing Pseudomonas

aeruginosa Antimicrobial Agents and Chemotherapy 59: 4974 - 4981.

Lassak J., Keilhauer E.C., Fürst M., Wuichet K., *Gödeke J., Starosta A.L., Chen J.-M., Sogaard-

Andersen L., Rohr J., Wilson D.N., *Häussler S., Mann M., Jung K. (2015) Arginine-rhamnosylation as

new strategy to activate translation elongation factor P Nature Chemical Biology 11: 266 - 270.

Oumeraci T., *Jensen V., Talbot S.R., Hofmann W., Kostrzewa M., Schlegelberger B., Von Neuhoff N.,

*Häussler S. (2015) Comprehensive MALDI-TOF biotyping of the non-redundant harvard

Pseudomonas aeruginosa PA14 transposon insertion mutant library PLoS ONE 10: e0117144.

*Pustelny C., *Komor U., *Pawar V., *Lorenz A., *Bielecka A., Moter A., Gocht B., *Eckweiler D.,

*Musken M., Grothe C., *Lunsdorf H., *Weiss S., *Häussler S. (2015) Contribution of Veillonella

parvula to Pseudomonas aeruginosa-mediated pathogenicity in a murine tumor model system

Infection and Immunity 83: 417 - 429.

*Schulz S., *Eckweiler D., *Bielecka A., *Nicolai T., *Franke R., *Dotsch A., *Hornischer K.,

*Bruchmann S., *Duvel J., *Häussler S. (2015) Elucidation of Sigma Factor-Associated Networks in

Pseudomonas aeruginosa Reveals a Modular Architecture with Limited and Function-Specific

Crosstalk PLoS Pathogens 11: 1 - 21.

Vercammen K., Wei Q., Charlier D., *Dötsch A., *Häussler S., *Schulz S., Salvi F., Gadda G., Spain J.,

Levin Rybtke M., Tolker-Nielsen T., Dingemans J., Ye L., Cornelis P. (2015) Pseudomonas aeruginosa

LysR PA4203 regulator nmoR acts as a repressor of the PA4202 nmoA gene, encoding a nitronate

monooxygenase Journal of Bacteriology 197: 1026 - 1039.

*Bielecki P., *Muthukumarasamy U., *Eckweiler D., *Bielecka A., *Pohl S., Schanz A., Niemeyer U.,

Oumeraci T., von Neuhoff N., Ghigo J.-M., *Häussler S. (2014) In Vivo mRNA profiling of

uropathogenic Escherichia coli from diverse phylogroups reveals common and group-specific gene

expression profiles mBio 5: e01075-14.

*Blanka A., *Schulz S., *Eckweiler D., *Franke R., *Bielecka A., *Nicolai T., *Casilag F., *Duvel J.,

*Abraham W.-R., Kaever V., *Häussler S. (2014) Identification of the alternative sigma factor SigX

regulon and its implications for Pseudomonas aeruginosa pathogenicity Journal of Bacteriology 196:

345 - 356.

Borrero-de Acuna J.M., *Bielecka A., *Häussler S., Schobert M., Jahn M., Wittmann C., Jahn D.,

*Poblete-Castro I. (2014) Production of medium chain length polyhydroxyalkanoate in metabolic flux

optimized Pseudomonas putida Microbial Cell Factories 13: 88.

*Brouwer S., *Pustelny C., *Ritter C., Klinkert B., Narberhaus F., *Häussler S. (2014) The PqsR and

RhlR transcriptional regulators determine the level of Pseudomonas quinolone signal synthesis in

Pseudomonas aeruginosa by producing two different pqsABCDE mRNA Isoforms Journal of

Bacteriology 196: 4163 - 4171.

29

Cabot G., *Bruchmann S., Mulet X., Zamorano L., Moya B., Juan C., *Häussler S., Oliver A. (2014)

Pseudomonas aeruginosa ceftolozane-tazobactam resistance development requires multiple

mutations leading to overexpression and structural modification of Ampc Antimicrobial Agents and

Chemotherapy 58: 3091 - 3099.

*Eckweiler D., Bunk B., Spröer C., Overmann .J, *Häussler S. (2014) Complete Genome Sequence of

Highly Adherent Pseudomonas aeruginosa Small-Colony Variant SCV20265 Genome Announcements

2: e01232-13.

*Pawar V., *Crull K., *Komor U., *Kasnitz N., *Frahm M., *Kocijancic D., *Westphal K., *Leschner S.,

*Wolf K., *Loessner H., *Rohde M., *Häussler S., *Weiss S. (2014) Murine solid tumours as a novel

model to study bacterial biofilm formation in vivo Journal of Internal Medicine 276: 130 - 139.

Perez F., Hujer A.M., Marshall S.H., Ray A.J., Rather P.N., Suwantarat N., Dumford D. 3rd, O'Shea P,

Domitrovic T.N., Salata R.A., Chavda K.D., Chen L., Kreiswirth B.N., Vila A.J., *Häussler S., Jacobs M.R.,

Bonomo R.A. (2014) Extensively drug-resistant Pseudomonas aeruginosa isolates containing blaVIM-2

and elements of Salmonella genomic island 2: A new genetic resistance determinant in northeast

Ohio Antimicrobial Agents and Chemotherapy 58: 5929 - 5935.

*Pohl S., Klockgether J., *Eckweiler D., *Khaledi A., *Schniederjans M., Chouvarine P., Tummler B.,

*Häussler S. (2014) The extensive set of accessory Pseudomonas aeruginosa genomic components

FEMS Microbiology Letters 356: 235 - 241.

*Schulz S., *Häussler S. (2014) Chromatin immunoprecipitation for ChIP-chip and ChIP-seq Methods

in Molecular Biology 1149: 591 - 605.

Schmidt A., Belaaouaj A., Bissinger R., Koller G., Malleret L., D'Orazio C., Facchinelli M., Schulte-

Hubbert B., Molinaro A., Holst O., Hammermann J., *Schniederjans M., Meyer K.C., Damkiaer S.,

Piacentini G., Assael B., Bruce K., *Häussler S., LiPuma J.J. (2014) Neutrophil elastase-mediated

increase in airway temperature during inflammation Journal of Cystic Fibrosis 13: 623 - 631.

Vidigal P.G., *Musken M., Becker K.A., *Häussler S., Wingender J., *Steinmann E., *Kehrmann J.,

Gulbins E., Buer J., Rath P.M., Steinmann J. (2014) Effects of green tea compound Epigallocatechin-3-

gallate against Stenotrophomonas maltophilia infection and biofilm PLoS ONE 9: e92876.

*Bielecki P., *Komor U., *Bielecka A., *Musken M., *Puchalka J., Pletz M.W., Ballmann M., *Martins

dos Santos V.A., *Weiss S., *Häussler S. (2013) Ex vivo transcriptional profiling reveals a common set

of genes important for the adaptation of Pseudomonas aeruginosa to chronically infected host sites


*Bruchmann S., *Dotsch A., *Nouri B., Chaberny I.F., *Häussler S. (2013) Quantitative contributions

of target alteration and decreased drug accumulation to Pseudomonas aeruginosa fluoroquinolone

resistance Antimicrobial Agents and Chemotherapy 57: 1361 - 1368.

Godeke J., *Pustelny C., *Häussler S. (2013) Recycling of peptidyl-tRNAs by peptidyl-tRNA hydrolase

counteracts azithromycin-mediated effects on Pseudomonas aeruginosa Antimicrobial Agents and


30

*Haussler S., Fuqua C. (2013) Biofilms 2012: New discoveries and significant wrinkles in a dynamic

field Journal of Bacteriology 195: 2947 - 2958.

*Pustelny C., *Brouwer S., *Musken M., *Bielecka A., *Dotsch A., *Nimtz M., *Häussler S. (2013) The

peptide chain release factor methyltransferase PrmC is essential for pathogenicity and environmental

adaptation of Pseudomonas aeruginosa PA14 Environmental Microbiology 15: 597 - 609.

31

Höfle Manfred G.

Deng J, Auchtung J, Konstantinidis KT, Caro-Quintero A, *Brettar I, *Höfle M, Tiedje JM. (2017) Divergence in gene regulation contributes to sympatric speciation of Shewanella baltica strains Applied and Environmental Microbiology 2017 Dec 8. pii: AEM.02015-17. doi: 10.1128/AEM.02015-17. Mizrahi H., Peretz A., *Lesnik R., Aizenberg-Gershtein Y., Rodríguez-Martínez S., Sharaby Y., Pastukh N., *Brettar I., *Höfle M.G., Halpern M. (2017) Comparison of sputum microbiome of legionellosis-associated patients and other pneumonia patients: Indications for polybacterial infections Scientific Reports 7: 40114. *Pereira R.P.A., Peplies J., *Brettar I., *Höfle M.G. (2017) Development of a genus-specific next generation sequencing approach for sensitive and quantitative determination of the Legionella microbiome in freshwater systems BMC Microbiology 17: 1 - 14. *Pereira R.P.A., Peplies J., *Höfle M.G., *Brettar I. (2017) Bacterial community dynamics in a cooling tower with emphasis on pathogenic bacteria and Legionella species using universal and genus-specific deep sequencing Water Research 122: 363 - 376. Sharaby Y., Rodríguez-Martínez S., Oks O., *Pecellin M., Mizrahi H., Peretz A., *Brettar I., *Höfle M.G., Halpern M. (2017) Temperature-dependent growth modeling of environmental and clinical Legionella pneumophila multilocus variable-number tandem-repeat analysis (MLVA) genotypes Applied and Environmental Microbiology 83: e03295-16. Vezzulli L., Grande C., Tassistro G., *Brettar I., *Höfle M.G., *Pereira R.P.A., *Mushi D., Pallavicini A., Vassallo P., Pruzzo C. (2017) Whole-Genome Enrichment Provides Deep Insights into Vibrio cholerae Metagenome from an African River Microbial Ecology 73: 734 - 738. *Brettar I., *Höfle M., Pruzzo C., Vezulli L. (2016) Climate change effects on planktonic bacterial communities in the ocean - from structure and function to long-term and large-scale observations In: J. Marxsen (ed.) "Microbial Ecology and Climate Change: Current Research and Future Trends", Caister Academic Press, Poole, UK : 23 - 39. *Lesnik R., *Brettar I., *Höfle M.G. (2016) Legionella species diversity and dynamics from surface reservoir to tap water: from cold adaptation to thermophily ISME Journal 10: 1064 - 1080. Seidel, M., Jurzik, L., *Brettar, I., *Höfle, M. G., Griebler, C. (2106) Microbial and viral pathogens in freshwater: current research aspects studied in Germany Environ. Earth Sci. 75:1384, doi: 10.1007/s12665-016-6189-x Vezzulli L., Grande C., Reid P.C., Hélaouët P., Edwards M., *Höfle M.G., *Brettar I., Colwell R.R., Pruzzo C. (2016) Climate influence on Vibrio and associated human diseases during the past half-century in the coastal North Atlantic Proceedings of the National Academy of Sciences of the United States of America 113: E5062 - E5071. *Kramer R., Sauer-Heilborn A., Welte T., *Guzman C.A., *Abraham W.-R., *Höfle M.G. (2015) Cohort study of airway mycobiome in adult cystic fibrosis patients: Differences in community structure between fungi and bacteria reveal predominance of transient fungal elements Journal of Clinical Microbiology 53: 2900 - 2907. *Kramer R., Sauer-Heilborn A., Welte T., *Guzman C.A., *Höfle M.G., *Abraham W.-R. (2015) A rapid method for breath analysis in cystic fibrosis patients European Journal of Clinical Microbiology and

32

Infectious Diseases 34: 745 - 751. *Kramer R., Sauer-Heilborn A., Welte T., *Jauregui R., *Brettar I., *Guzman C.A., *Höfle M.G. (2015) High individuality of respiratory bacterial communities in a large cohort of adult cystic fibrosis patients under continuous antibiotic treatment PLoS ONE 10: e0117436. Rodriguez-Martinez S., Sharaby Y., *Pecellin M., *Brettar I., *Höfle M., Halpern M. (2015) Spatial distribution of Legionella pneumophila MLVA-genotypes in a drinking water system Water Research 77: 119 - 132. Vezzulli L., Pezzati E., *Brettar I., *Höfle M., Pruzzo C. (2015) Effects of global warming on Vibrio ecology Microbiology Spectrum 3: VE-0004-2014. Deng J., *Brettar I., Luo C., Auchtung J., Konstantinidis K.T., Rodrigues J.L.M., *Höfle M., Tiedje J.M. (2014) Stability, genotypic and phenotypic diversity of Shewanella baltica in the redox transition zone of the Baltic Sea Environmental microbiology 16: 1854 - 1866. *Henne K., *Kahlisch L., *Höfle M.G., *Brettar I. (2013) Seasonal dynamics of bacterial community structure and composition in cold and hot drinking water derived from surface water reservoirs Water Research 47: 5614 - 5630.

33

Kolbe, Michael

*Horstmann J.A., *Zschieschang E., Truschel T., *de Diego J., *Lunelli M., *Rohde M., May T.,

*Strowig T., *Stradal T., *Kolbe M., *Erhardt M. (2017) Flagellin phase-dependent swimming on

epithelial cell surfaces contributes to productive Salmonella gut colonisation Cellular Microbiology

19: e12739.

34

Krause, Gérard

*Bohm K., Filomena A., Schneiderhan-Marra N., *Krause G., *Sievers C. (2017) Validation of HAV

biomarker 2A for differential diagnostic of hepatitis A infected and vaccinated individuals using

multiplex serology Vaccine 35: 5883 - 5889.

Cuny C, Arnold P, Hermes J, Eckmanns T, *Mehraj J, Schoenfelder S, Ziebuhr W, Zhao Q, Wang Y,

Feßler AT, *Krause G, Schwarz S, Witte W. (2017) Occurrence of cfr-mediated multiresistance in

staphylococci from veal calves and pigs, from humans at the corresponding farms, and from

veterinarians and their family members Veterinary Microbiology 200: 88 - 94.

Filomena A., *Pessler F., *Akmatov M.K., *Krause G., Duffy D., Gärtner B., Gerhard M., Albert M.L.,

Joos T.O., Schneiderhan-Marra N. (2017) Development of a bead-based multiplex assay for the

analysis of the serological response against the six pathogens HAV, HBV, HCV, CMV, T. gondii, and H.

pylori High-Throughput 6: 14.

Karo B., *Krause G., *Castell S., Kollan C., Hamouda O., Haas W., Kühne A., Arastéh K., Bergmann F.,

Warncke M., Rockstroh J., Wasmuth J., Hass S., Jensen B., Feind C., Esser S., Schenk-Westkamp P.,

Stephan C., Haberl A., Schott P., Plettenberg A., Kuhlen (2017) Immunological recovery in

tuberculosis/HIV co-infected patients on antiretroviral therapy: Implication for tuberculosis

preventive therapy BMC Infectious Diseases 17: 517.

*Ott J.J., *Horn J., *Krause G., *Mikolajczyk R.T. (2017) Time trends of chronic HBV infection over

prior decades - A global analysis Journal of Hepatology 66: 48 - 54.

*Schweitzer A., *Akmatov M.K., *Krause G. (2017) Hepatitis B vaccination timing: Results from

demographic health surveys in 47 countries Bulletin of the World Health Organization 95: 199 - 209.

Karo B., *Krause G., Hollo V., van der Werf M.J., *Castell S., Hamouda O., Haas W. (2016) The impact

of HIV infection on treatment outcome of tuberculosis: analysis of surveillance data from nine

European countries, 2010–2012 AIDS 30: 1089 - 1098.

*Klett-Tammen C.J., *Krause G., Seefeld L., *Ott J.J. (2016) Determinants of tetanus, pneumococcal

and influenza vaccination in the elderly: A representative cross-sectional study on knowledge,

attitude and practice (KAP) BMC Public Health 16: 121.

*Klett-Tammen C.J., *Krause G., Von Lengerke T., *Castell S. (2016) Advising vaccinations for the

elderly: A cross-sectional survey on differences between general practitioners and physician

assistants in Germany BMC Family Practice 17: 98.

*Mehraj J., Witte W., *Akmatov M.K., Layer F., Werner G., *Krause G. (2016) Epidemiology of

Staphylococcus aureus nasal carriage patterns in the community Current Topics in Microbiology and

Immunology 398: 55 - 87.

Moyer D., *Tom-Aba D., Sharma S., *Krause G. (2016) Taking digital innovation into the field of

infectious diseases: The case of SORMAS(r) Shaping the Digital Enterprise: Trends and Use Cases in

Digital Innovation and Transformation: 219 - 236.

Smieszek T., *Castell S., Barrat A., Cattuto C., White P.J., *Krause G. (2016) Contact diaries versus

35

wearable proximity sensors in measuring contact patterns at a conference: Method comparison and

participants' attitudes BMC Infectious Diseases 16: 341.

*Akmatov M.K., *Rübsamen N., *Schultze A., *Kemmling Y., Obi N., Günther K., Ahrens W., *Pessler

F., *Krause G., *Mikolajczyk R.T. (2015) Diverse recruitment strategies result in different participation

percentages in a web-based study, but in similar compliance International Journal of Public Health

60: 937 - 943.

*Akmatov M.K., Kimani-Murage E., *Pessler F., *Guzman C.A., *Krause G., Kreienbrock L.,

*Mikolajczyk R.T. (2015) Evaluation of invalid vaccine doses in 31 countries of the WHO African

Region Vaccine 33: 892 - 901.

Fähnrich C., *Denecke K., Adeoye O.O., Benzler J., Claus H., Kirchner G., *Mall S., Richter R.,

Schapranow M.P., Schwarz N., *Tom-Aba D., Uflacker M., Poggensee G., *Krause G. (2015)

Surveillance and Outbreak Response Management System (SORMAS) to support the control of the

Ebola virus disease outbreak in West Africa Eurosurveillance 20: 21071.

Harder T., Abu Sin M., Bosch-Capblanch X., Coignard B., de Carvalho Gomes H., Duclos P., Eckmanns

T., Elder R., Ellis S., Forland F., Garner P., James R., Jansen A., *Krause G., Levy-Bruhl D., Morgan A.,

Meerpohl J.J., Norris S., Rehfuess E., Sanchez-Viva (2015) Towards a framework for evaluating and

grading evidence in public health Health Policy 119: 732 - 736.

Mohr O., Schink S.B., Eckmanns T., *Krause G. (2015) Tuberculosis in public ground transport-is there

enough evidence to justify contact tracing? Expert Review of Anti-Infective Therapy 13: 1 - 3.

*Rübsamen N., *Castell S., *Horn J., *Karch A., *Ott J.J., *Raupach-Rosin H., *Zoch B., *Krause G.,

*Mikolajczyk R.T. (2015) Ebola risk perception in Germany, 2014 Emerging Infectious Diseases 21:

1012 - 1018.

Santos-Hövener C., Marcus U., Koschollek C., Oudini H., Wiebe M., Ouedraogo O.I., Mayamba P.,

M'bayo R., Sanogo A., Bakambamba A., Gangarova T., Hamouda O., Dierks M.-L., *Krause G. (2015)

Designing a study on sexual health of Africans living in Germany Prävention und

Gesundheitsförderung 10: 68 - 75.

Santos-Hövener C., Marcus U., Koschollek C., Oudini H., Wiebe M., Ouedraogo O.I., Thorlie A., Bremer

V., Hamouda O., Dierks M.-L., An Der Heiden M., *Krause G. (2015) Determinants of HIV, viral

hepatitis and STI prevention needs among African migrants in Germany; a cross-sectional survey on

knowledge, attitudes, behaviors and practices BMC Public Health 15: 753.

*Schweitzer A., *Akmatov M.K., *Kindler F., *Kemmling Y., Kreienbrock L., *Krause G., *Pessler F.

(2015) The impact of distance and duration of travel on participation rates and participants'

satisfaction: Results from a pilot study at one study centre in Pretest 2 of the German National

Cohort BMJ Open 5: e007461.

*Schweitzer A., *Horn J., *Mikolajczyk R.T., *Krause G., *Ott J.J. (2015) Estimations of worldwide

prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965

and 2013 The Lancet 386: 1546 - 1555.

36

*Schweitzer A., *Krause G., *Pessler F., *Akmatov M.K. (2015) Improved coverage and timing of

childhood vaccinations in two post-Soviet countries, Armenia and Kyrgyzstan BMC Public Health 15:

798.

*Akmatov M.K., *Mehraj J., *Gatzemeier A., *Strömpl J., Witte W., *Krause G., *Pessler F. (2014)

Serial home-based self-collection of anterior nasal swabs to detect Staphylococcus aureus carriage in

a randomized population-based study in Germany International Journal of Infectious Diseases 25: e4

- e10.

*Castell S., *Akmatov M.K., Obi N., Flesh-Janys D., Nieters A., *Kemmling Y., *Pessler F., *Krause G.

(2014) Test–retest reliability of an infectious disease questionnaire and evaluation of self-assessed

vulnerability to infections: Findings of Pretest 2 of the German National Cohort

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 57: 1300 - 1307.

*Castell S., *Krause G., Schmitt M., Pawlita M., Delere Y., Obi N., Flesch-Janys D., *Kemmling Y.,

Kaufmann A.M. (2014) Feasibility and acceptance of cervicovaginal self-sampling within the German

National Cohort (Pretest 2) Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz

57: 1270 - 1276.

Linseisen J., Peters A., Pischon T., Willich S., Keil T., Boeing H., Ahrens W., Zeeb H., Kuss O., Giani G.,

Hoffmann B., Jöckel K.H., Moebus S., Michels K., Schmoor C., Stang A., Haerting J., Flesch-Janys D.,

Obi N., *Krause G., Lieb W., Nöthlings U., Löffler M., Thiery .J, Kaaks R., Greiser K.H., Becher H.,

Berger K., Hense H.W., Völzke H., Hoffman W., Leitzmann M., Heid I.M., Brenner H., Stegmaier C.,

Kurth B.M., Schlaud M., Mueller U.O., Bamberg F., Swart E., Günther M., Ahrens W., Hoffmann W.,

Jöckel K.H., Kaaks R., Gromer B., Greiser K.H., Linseisen J., Schmidt B., Wichmann H.E., Weg-Remers S.

(2014) The German National Cohort: aims, study design and organization European Journal of

Epidemiology 29: 371 - 382.

Harder T., Takla A., Rehfuess E., Sanchez-Vivar A., Matysiak-Klose D., Eckmanns T., *Krause G., De

Carvalho Gomes H., Jansen A., Ellis S., Forland F., James R., Meerpohl J.J., Morgan A., Schunemann H.,

Zuiderent-Jerak T., Wichmann O. (2014) Evidence-based decision-making in infectious diseases

epidemiology, prevention and control: Matching research questions to study designs and quality

appraisal tools BMC Medical Research Methodology 14: 69.

*Mall S., *Akmatov M.K., *Schultze A., Ahrens W., Obi N., *Pessler F., *Krause G. (2014) Web-based

questionnaires to capture acute infections in long-term cohorts: Findings of a feasibility study


*Mehraj J., *Akmatov M.K., *Strömpl J., *Gatzemeier A., Layer F., Werner G., *Pieper D.H., *Medina

E., Witte W., *Pessler F., *Krause G. (2014) Methicillin-sensitive and methicillin-resistant

Staphylococcus aureus nasal carriage in a random sample of non-hospitalized adult population in

Northern Germany PLoS ONE 9: e107937.

Plass D., Mangen M.-J.J., Kraemer A., Pinheiro P., Gilsdorf A., *Krause G., Gibbons C.L., Van Lier A.,

McDonald S.A., Brooke R.J., Kramarz P., Cassini A., Kretzschmar M.E.E. (2014) The disease burden of

hepatitis B, influenza, measles and salmonellosis in Germany: First results of the Burden of

Communicable Diseases in Europe Study Epidemiology and Infection 142: 2024 - 2035.

37

*Schultze A., *Akmatov M.K., *Andrzejak M., Karras N., *Kemmling Y., *Maulhardt A., *Wieghold S.,

Ahrens W., Gunther K., Schlenz H., *Krause G., *Pessler F. (2014) Comparison of stool collection on

site versus at home in a population-based study: Feasibility and participants’ preference in Pretest 2

of the German National Cohort Bundesgesundheitsblatt - Gesundheitsforschung -

Gesundheitsschutz 57: 1264 - 1269.

*Schultze A., *Akmatov M.K., *Castell S., *Karch A., Ahrens W., Gunther K., Schlenz H., Flesch-Janys

D., Obi N., *Pessler F., *Krause G. (2014) Collection of vaccination data in the German National

Cohort: Findings of a feasibility study in three study centers Bundesgesundheitsblatt -

Gesundheitsforschung - Gesundheitsschutz 57: 1292 - 1299.

*Sievers C., *Akmatov M.K., Kreienbrock L., Hille K., Ahrens W., Gunther K., Flesch-Janys D., Obi N.,

Michels K.B., Fricke J., Greiser K.H., Kaaks R., Peter H.-H., *Pessler F., Nieters A., *Krause G. (2014)

Evaluation of a questionnaire to assess selected infectious diseases and their risk factors: Findings of

a multicenter study Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 57: 1283 -

1291.

Balabanova Y., Klar S., Delere Y., Wilking H., Faber M.S., Lassen S.G., Gilsdorf A., Dupke S., Nitschke

M., Sayk F., Grunow R., *Krause G. (2013) Serological Evidence of Asymptomatic Infections during

Escherichia coli O104:H4 Outbreak in Germany in 2011 PLoS ONE 8: e73052.

Cediel-Becerra N.M., *Krause G. (2013) Evidence-based public health decision-making tools which

can also be used for prioritising disease Revista de Salud Publica 15: 694 - 706.

Mohr O., Hermes J., Schink S.B., Askar M., Menucci D., Swaan C., Goetsch U., Monk P., Eckmanns T.,

Poggensee G., *Krause G. (2013) Development of a risk assessment tool for contact tracing people

after contact with infectious patients while travelling by bus or other public ground transport: A

Delphi consensus approach BMJ Open 3: e002939.

Ultsch B., Koster I., Reinhold T., Siedler A., *Krause G., Icks A., Schubert I., Wichmann O. (2013)

Epidemiology and cost of herpes zoster and postherpetic neuralgia in Germany European Journal of

Health Economics 14: 1015 - 1026.

Ultsch B., Weidemann F., Reinhold T., Siedler A., *Krause G., Wichmann O. (2013) Health economic

evaluation of vaccination strategies for the prevention of herpes zoster and postherpetic neuralgia in

Germany BMC Health Services Research 13: 359.

38

McHardy, Alice C.

Doerrenberg M., *Kloetgen A., Hezaveh K., Wössmann W., Bleckmann K., Stanulla M., Schrappe M.,

*McHardy A.C., Borkhardt A., Hoell J.I. (2017) T-cell acute lymphoblastic leukemia in infants has

distinct genetic and epigenetic features compared to childhood cases Genes Chromosomes and

Cancer 56: 159 - 167.

Dong X., *Dröge J., von Toerne C., Marozava S., *McHardy A.C., Meckenstock R.U. (2017)

Reconstructing metabolic pathways of a member of the genus Pelotomaculum suggesting its

potential to oxidize benzene to carbon dioxide with direct reduction of sulfate FEMS microbiology

ecology 93 doi: 10.1093/femsec/fiw254.

*Dröge J., Schönhuth A., *McHardy A.C. (2017) A probabilistic model to recover individual genomes

from metagenomes PeerJ Computer Science 3: e117.

Grießmeier V., *Bremges A., *McHardy A.C., Gescher J. (2017) Investigation of different nitrogen

reduction routes and their key microbial players in wood chip-driven denitrification beds Scientific

Reports 7: 17028.

*Klingen T.R., *Reimering S., *Guzmán C.A., *McHardy A.C. (2017) In Silico Vaccine Strain Prediction

for Human Influenza Viruses Trends in Microbiology doi: 10.1016/j.tim.2017.09.001.

Krause S., *Bremges A., *Münch P.C., *McHardy A.C., Gescher J. (2017) Characterisation of a stable

laboratory co-culture of acidophilic nanoorganisms Scientific Reports 7: 3289.

Kunath B.J., *Bremges A., *Weimann A., *McHardy A.C., Pope P.B. (2017) Metagenomics and

CAZyme discovery Methods in Molecular Biology 1588: 255 - 277.

Maus I., *Bremges A., Stolze Y., Hahnke S., Cibis K.G., Koeck D.E., Kim Y.S., Kreubel J., Hassa J.,

Wibberg D., *Weimann A., Off S., Stantscheff R., Zverlov V.V., Schwarz W.H., König H., Liebl W.,

Scherer P., *McHardy A.C., Sczyrba A., Klocke M., Pühler A. (2017) Genomics and prevalence of

bacterial and archaeal isolates from biogas-producing microbiomes Biotechnology for Biofuels 10:

264.

*McHardy A.C., Kloetgen A. (2017) Finding genes in genome sequence Methods in Molecular Biology

1525: 271 - 291.

*Münch P.C., Stecher B., *McHardy A.C. (2017) EDEN: Evolutionary dynamics within environments

Bioinformatics 33: 3292 - 3295.

Sczyrba A., Hofmann P., Belmann P., Koslicki D., Janssen S., Dröge J., Gregor I., Majda S., Fiedler J.,

Dahms E., Bremges A., Fritz A., Garrido-Oter R., Jørgensen T.S., Shapiro N., Blood P.D., Gurevich A.,

Bai Y., Turaev D., DeMaere M.Z., Chikhi R., Nagarajan N., …, *McHardy, A.C. (2017) Critical

Assessment of Metagenome Interpretation-a benchmark of metagenomics software Nature

Methods 14: 1063 – 1071

Ye Z., Pan Y., Zhang Y., Cui H., Jin G., McHardy A.C., Fan L., Yu X. (2017) Comparative whole-genome

analysis reveals artificial selection effects on Ustilago esculenta genome DNA Research 24: 635 - 648.

39

Brugiroux S., Beutler M., Pfann C., Garzetti D., Ruscheweyh H.-J., Ring D., Diehl M., Herp S., Lötscher

Y., Hussain S., Bunk B., Pukall R., Huson D.H., *Münch P.C., *McHardy A.C., McCoy K.D., MacPherson

A.J., Loy A., Clavel T., Berry D., Stecher B. (2016) Genome-guided design of a defined mouse

microbiota that confers colonization resistance against Salmonella enterica serovar Typhimurium

Nature Microbiology 2: 16215.

Frank J.A., *Pan Y., Tooming-Klunderud A., Eijsink V.G.H., *McHardy A.C., Nederbragt A.J., Pope P.B.

(2016) Improved metagenome assemblies and taxonomic binning using long-read circular consensus

sequence data Scientific Reports 6: 25373.

Frank J.A., Arntzen M.Ø., Sun L., Hagen L.H., *McHardy A.C., Horn S.J., Eijsink V.G., Schnürer A., Pope

P.B. (2016) Novel Syntrophic Populations Dominate an Ammonia-Tolerant Methanogenic

Microbiome mSystems 1: e00092 - 16.

*Gregor I., *Dröge J., Schirmer M., Quince C., *McHardy A.C. (2016) PhyloPythiaS+: A self-training

method for the rapid reconstruction of low-ranking taxonomic bins from metagenomes PeerJ 4 :

e1603.

*Gregor I., Schönhuth A., *McHardy A.C. (2016) Snowball: Strain aware gene assembly of

metagenomes Bioinformatics 32: i649 - i657.

Hacquard S., Kracher B., Hiruma K., *Münch P.C., Garrido-Oter R., Thon M.R., *Weimann A., Damm

U., Dallery J.F., Hainaut M., Henrissat B., Lespinet O., Sacristán S., Ver Loren Van Themaat E., Kemen

E., *McHardy A.C., Schulze-Lefert P., O'Connell R.J. (2016) Survival trade-offs in plant roots during

colonization by closely related beneficial and pathogenic fungi Nature Communications 7: 11362.

Hezaveh K., Kloetgen A., Bernhart S.H., Mahapatra K.D., Lenze D., Richter J., Haake A., Bergmann A.

K., Brors B., Burkhardt B., Claviez A., Drexler H.G., Eils R., Haas S., Hoffmann S., Karsch D., Klapper W.,

Kleinheinz K., Korbel J., Kretzmer H., Kreuz M., Kuppers R., ...McHardy A.C., Moller P., Rohde M., …

Hoell J.I. (2016) Alterations of miRNAs and miRNA-regulated mRNA expression in GC B cell

lymphomas determined by integrative sequencing analysis Haematologica 101: 1380 - 1389.

Ikeda-Ohtsubo W., Strassert J.F.H., Köhler T., Mikaelyan A., *Gregor I., *McHardy A.C., Tringe S.G.,

Hugenholtz P., Radek R., Brune A. (2016) 'Candidatus Adiutrix intracellularis', an endosymbiont of

termite gut flagellates, is the first representative of a deep-branching clade of Deltaproteobacteria

and a putative homoacetogen Environmental Microbiology 18: 2548 - 2564.

*Kloetgen A., Borkhardt A., Hoell J.I., *McHardy A.C. (2016) The PARA-suite: PAR-CLIP specific

sequence read simulation and processing PeerJ 4: e2619.

Kratsch C., *Klingen T.R., Mümken L., Steinbrück L., *McHardy A.C. (2016) Determination of

antigenicity-altering patches on the major surface protein of human influenza A/H3N2 viruses Virus

Evolution 2: vev025.

Laehnemann D., Borkhardt A., McHardy A.C. (2016) Denoising DNA deep sequencing data high-

throughput sequencing errors and their correction Briefings in Bioinformatics 17: 154 - 179.

40

Otte A., Marriott A.C., Dreier C., Dove B.,* Mooren K., *Klingen T.R., Sauter M., Thompson K.A.,

Bennett A., Klingel K., Van Riel D., *McHardy A.C., Carroll M.W., Gabriel G. (2016) Evolution of 2009

H1N1 influenza viruses during the pandemic correlates with increased viral pathogenicity and

transmissibility in the ferret model Scientific Reports 6: 28583.

*Weimann A., *Mooren K., Frank J., Pope P.B., *Bremges A., *McHardy A.C. (2016) From Genomes to

Phenotypes: Traitar, the Microbial Trait Analyzer mSystems 1: e00101 - 16.

Bai Y., Müller D.B., Srinivas G., Garrido-Oter R., Potthoff E., Rott M., Dombrowski N., *Münch P.C.,

Spaepen S., Remus-Emsermann M., Hüttel B., *McHardy A.C., Vorholt J.A., Schulze-Lefert P. (2015)

Functional overlap of the Arabidopsis leaf and root microbiota Nature 528: 364 - 369.

Belmann P., *Dröge J., *Bremges A., *McHardy A.C., Sczyrba A., Barton M.D. (2015) Bioboxes:

standardised containers for interchangeable bioinformatics software Gigascience 4: 47.

Bulgarelli D., Garrido-Oter R., Münch P., Weiman A., Droge J., Pan Y., *McHardy A., Schulze-Lefert P.

(2015) Structure and Function of the Bacterial Root Microbiota in Wild and Domesticated Barley Cell

Host and Microbe 17: 392 - 403.

Dröge J., Gregor I., *McHardy A.C. (2015) Taxator-tk: Precise taxonomic assignment of metagenomes

by fast approximation of evolutionary neighborhoods Bioinformatics 31: 817 - 824.

Fischer U., Forster M., Rinaldi A., Risch T., Sungalee S., Warnatz H.J., Bornhauser B., Gombert M.,

Kratsch C., Stutz A.M., Sultan M., Tchinda J., Worth C.L., Amstislavskiy V., Badarinarayan N., Baruchel

A., Bartram T., Basso G., Canpolat C., Cario G., Cave H., Dakaj D., Delorenzi M., … *McHardy A.C., … ,

Yaspo M.L. (2015) Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic

leukemia identifies recurrent mutation patterns and therapeutic options. Nature Genetics 47: 1020 -

1029.

Gubry-Rangin C., *Kratsch C., Williams T.A., *McHardy A.C., Embley T.M., Prosser J.I., Macqueen D.J.

(2015) Coupling of diversification and pH adaptation during the evolution of terrestrial

Thaumarchaeota Proceedings of the National Academy of Sciences of the United States of America

112: 9370 - 9375.

Hacquard S., Garrido-Oter R., Gonzalez A., Spaepen S., Ackermann G., Lebeis S., *McHardy A.C.,

Dangl J.L., Knight R., Ley R., Schulze-Lefert P. (2015) Microbiota and host nutrition across plant and

animal kingdoms Cell Host and Microbe 17: 603 - 616.

Kloetgen A., Münch P.C., Borkhardt A., Hoell J.I., *McHardy A.C. (2015) Biochemical and

bioinformaticmethods for elucidating the role of RNA-protein interactions in posttranscriptional

regulation Briefings in Functional Genomics 14: 102 - 114.

*McHardy A.C. (2015) How to Grow a Computational Biology Lab PLoS Computational Biology 11:

e1004397.

*McHardy A.C. (2015) PhyloPythia(S) Encyclopedia of Metagenomics - Genes, Genomes and

Metagenomes. Basics, Methods, Databases and Tools, Karen E. Nelson, Ed. (Springer US).

41

Otte A., Sauter M., Daxer M.A., *McHardy A.C., Klingel K., Gabriel G. (2015) Adaptive mutations that

occurred during circulation in humans of H1N1 influenza virus in the 2009 pandemic enhance

virulence in mice Journal of Virology 89: 7329 - 7337.

Guttman D.S., *McHardy A.C. , Schulze-Lefert P. (2014) Microbial genome-enabled insights into plant-

microorganism interactions. Nature Reviews Genetics 15: 797 - 813. ¶ Shared last authors.

Kratsch C., McHardy A.C. (2014) RidgeRace: ridge regression for continuous ancestral character

estimation on phylogenetic trees Bioinformatics 30: i527 - 533.

Konietzny S.G., Pope P.B., Weimann A., McHardy A.C. (2014) Inference of phenotype-defining

functional modules of protein families for microbial plant biomass degraders Biotechnology for

Biofuels 7: 124.

Steinbrück L., *McHardy A.C. (2014) Evaluating the Evolutionary Dynamics of Viral Populations

Dynamic Models of Infectious Diseases, V. S. H. Rao, Ed. (Springer, New York).

Steinbrück L., *Klingen T.R., *McHardy A.C. (2014) Computational prediction of vaccine strains for

human influenza A (H3N2) viruses Journal of Virology 88: 12123 - 12132.

Gregor I., Steinbrück L., *McHardy A.C. (2013) PTree: pattern-based, stochastic search for maximum

parsimony phylogenies PeerJ 1: e89.

Patil K.R., *McHardy A.C. (2013) Alignment-free genome tree inference by learning group-specific

distance metrics Genome Biology and Evolution 5: 1470 - 1484.

Rohr C., Kerick M., Fischer A., Kuhn A., Kashofer K., Timmermann B., Daskalaki A., Meinel T., Drichel

D., Borno S.T., Nowka A., Krobitsch S., *McHardy A.C., … , Schweiger M.R. (2013) High-throughput

miRNA and mRNA sequencing of paired colorectal normal, tumor and metastasis tissues and

bioinformatic modeling of miRNA-1 therapeutic applications PLoS One 8: e67461.

Weimann A., Trukhina Y., Pope P.B., Konietzny S.G., *McHardy A.C. (2013) De novo prediction of the

genomic components and capabilities for microbial plant biomass degradation from (meta-)genomes

Biotechnology for Biofuels 6: 24.

42

Mikolajczyk, Rafael T.

*Bakuli A., *Klawonn F., *Karch A., *Mikolajczyk R. (2017) Effects of pathogen dependency in a multi-

pathogen infectious disease system including population level heterogeneity-a simulation study

Theoretical Biology and Medical Modelling 14: 26.

Baumann U, Adam R, Duvoux C, *Mikolajczyk R, Karam V, D'Antiga L, Chardot C, Coker A, Colledan M,

Erizon BG, Line PD, Hadzic N, Isoniemi H, Klempnauer JL, Reding R, McKiernan PJ, McLin V, Paul A,

Salizzoni M, Furtado ESB, Schneeberger S, *Karch A. (2017) Survival of children after liver

transplantation for hepatocellular carcinoma Liver Transplantation Liver Transpl. 2017 Dec 9. doi:

10.1002/lt.24994.

Boehne M, Sasse M, *Karch A, Dziuba F, Horke A, Kaussen T, *Mikolajczyk R, Beerbaum P, Jack T.

(2017) Systemic inflammatory response syndrome after pediatric congenital heart surgery: Incidence,

risk factors, and clinical outcome Journal of Cardiac Surgery 32: 116 - 125.

*Bongartz H., *Rübsamen N., *Raupach-Rosin H., *Akmatov M.K., *Mikolajczyk R.T. (2017) Why do

people participate in health-related studies? International Journal of Public Health 62: 1059 - 1062.

*Chaw P.S., *Schlinkmann K.M., *Raupach-Rosin H., *Karch A., Pletz M.W., Huebner J., *Mikolajczyk

R. (2017) Knowledge, attitude and practice of Gambian health practitioners towards antibiotic

prescribing and microbiological testing: A crosssectional survey Transactions of the Royal Society of

Tropical Medicine and Hygiene 111: 117 - 124.

Damm O., *Horn J., *Mikolajczyk R.T., Kretzschmar M.E.E., Kaufmann A.M., Deleré Y., Ultsch B.,

Wichmann O., Krämer A., Greiner W. (2017) Cost-effectiveness of human papillomavirus vaccination

in Germany Cost Effectiveness and Resource Allocation 15: 18.

Kreitmeyr K., von Both U., Pecar A., Borde J.P., *Mikolajczyk R., Huebner J. (2017) Pediatric antibiotic

stewardship: successful interventions to reduce broad-spectrum antibiotic use on general pediatric

wards Infection 45: 493 - 504.

Lindemann C, Langner I, Banaschewski T, Garbe E, *Mikolajczyk RT. (2017) The Risk of

Hospitalizations with Injury Diagnoses in a Matched Cohort of Children and Adolescents with and

without Attention Deficit/Hyperactivity Disorder in Germany: A Database Study Frontiers in

Pediatrics 5: 220.

Luque Ramos A., Ohlmeier C., Enders D., Linder R., Horenkamp-Sonntag D., Prochaska J.H.,

*Mikolajczyk R., Garbe E. (2017) Initiation and duration of dual antiplatelet therapy after inpatient

percutaneous coronary intervention with stent implantation in Germany: An electronic healthcare

database cohort study Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen 120:

31 - 38.

Maier I.L., *Karch A., Lipke C., Behme D., Mpotsaris A., Kabbasch C., Liebig T., Faymonville A., Reich

A., Nikoubashman O., Buhk J.-H., von Schoenfeld P., Weber W., *Mikolajczyk R.T., Bähr M., Knauth

M., Kallenberg K., Liman J. (2017) Transluminal angioplasty and stenting versus conservative

treatment in patients with symptomatic basilar artery stenosis: Perspective for future clinical trials

43

Clinical Neuroradiology 2016 Aug 9. doi: 10.1007/s00062-016-0528-x.

Maier I.L., Schregel K., *Karch A., Weber-Krueger M., *Mikolajczyk R.T., Stahrenberg R., Gröschel K.,

Bähr M., Knauth M., Psychogios M.-N., Wachter R., Liman J. (2017) Association between Embolic

Stroke Patterns, ESUS Etiology, and New Diagnosis of Atrial Fibrillation: A Secondary Data Analysis of

the Find-AF Trial Stroke Research and Treatment 2017: 1391843.

*Meyer F., *Karch A., *Schlinkmann K.M., Dreesman J., *Horn J., *Rübsamen N., Sudradjat H.,

Schubert R., *Mikolajczyk R. (2017) Sociodemographic determinants of spatial disparities in early

childhood caries: An ecological analysis in Braunschweig, Germany Community Dentistry and Oral

Epidemiology 45: 442 - 448.

*Obenauer J, *Rübsamen N, *Castell S, *Hoodgarzadeh M, *Klett-Tammen CJ, *Mikolajczyk RT,

*Karch A. (2017) Perceptions of Zika virus risk in Germany in 2016 European Journal of Public Health

Eur J Public Health. 2017 Jul 4. doi: 10.1093/eurpub/ckx092.

*Ott J.J., *Horn J., *Krause G., *Mikolajczyk R.T. (2017) Time trends of chronic HBV infection over

prior decades - A global analysis Journal of Hepatology 66: 48 - 54.

*Raupach-Rosin H., *Duddeck A., *Gehrlich M., *Helmke C., Huebner J., Pletz M.W., *Mikolajczyk R.,

*Karch A. (2017) Deficits in knowledge, attitude, and practice towards blood culture sampling: results

of a nationwide mixed-methods study among inpatient care physicians in Germany Infection 45: 433

- 441.

*Rübsamen N., *Akmatov M.K., *Castell S., *Karch A., *Mikolajczyk R.T. (2017) Factors associated

with attrition in a longitudinal online study: Results from the HaBIDS panel BMC Medical Research

Methodology 17: 132.

*Rübsamen N., *Akmatov M.K., *Castell S., *Karch A., *Mikolajczyk R.T. (2017) Comparison of

response patterns in different survey designs: a longitudinal panel with mixed-mode and online-only

design Emerging Themes in Epidemiology 14: 4.

*Schlinkmann K.M., *Raupach-Rosin H., Hübner J., *Mikolajczyk R. (2017) Infection prevention at

preschool age - What is reasonable? Tagliche Praxis 58: 421 - 433.

Stich H., *Schlinkmann K.M., *Mikolajczyk R. (2017) Competing Validity of Developmental Diagnostic

in School Entry Examination: Results of a Census in an Upper Bavarian District Gesundheitswesen

doi: 10.1055/s-0043-116939

Thöne K., *Horn J., *Mikolajczyk R. (2017) Evaluation of vaccination herd immunity effects for

anogenital warts in a low coverage setting with human papillomavirus vaccine - an interrupted time

series analysis from 2005 to 2010 using health insurance data BMC Infectious Diseases 17: 564.

*Zoch B., *Günther A., *Karch A., *Mikolajczyk R. (2017) Effect of Disease Definition on Perceived

Burden of Acute Respiratory Infections in Children -A Prospective Cohort Study Based on Symptom

Diaries Pediatric Infectious Disease Journal 36: 956 - 961.

*Belik V., Hövel P., *Mikolajczyk R. (2016) Control of epidemics on hospital networks Understanding

44

Complex Systems: 431 - 440.

Brisson M., Bénard É., Drolet M., Bogaards J.A., Baussano I., Vänskä S., Jit M., Boily M.C., Smith M.A.,

Berkhof J., Canfell K., Chesson H.W., Burger E.A., Choi Y.H., De Blasio B.F., De Vlas S.J., Guzzetta G.,

Hontelez J.A.C., Horn J., Jepsen M.R., Kim J.J., Lazzarato F., Matthijsse S.M., *Mikolajczyk R., Pavelyev

A., Pillsbury M., Shafer L.A., Tully S.P., Turner H.C., Usher C., Walsh C. (2016) Population-level impact,

herd immunity, and elimination after human papillomavirus vaccination: a systematic review and

meta-analysis of predictions from transmission-dynamic models The Lancet Public Health 1: e8-e17.

Conzen C., Conzen M., *Rübsamen N., *Mikolajczyk R. (2016) Predictors of the patient-centered

outcomes of surgical carpal tunnel release - A prospective cohort study BMC Musculoskeletal

Disorders 17: 1046.

Dempsey R.C., McALaney J., Helmer S.M., Pischke C.R., Akvardar Y., Bewick B.M., Fawkner H.J.,

Guillen-Grima F., Stock C., Vriesacker B., Van Hal G., Salonna F., Kalina O., Orosova O., *Mikolajczyk R.

(2016) Normative perceptions of cannabis use among European university students: Associations of

perceived peer use and peer attitudes with personal use and attitudes Journal of Studies on Alcohol

and Drugs 77: 740 - 748.

Helmer S.M., Sebena R., McAlaney J., Petkeviciene J., Salonna F., Lukács A., *Mikolajczyk R.T. (2016)

Perception of High Alcohol Use of Peers Is Associated With High Personal Alcohol Use in First-Year

University Students in Three Central and Eastern European Countries Substance Use and Misuse 51:

1224 - 1231.

*Horn J., *Karch A., Damm O., Kretzschmar M.E., Siedler A., Ultsch B., Weidemann F., Wichmann O.,

Hengel H., Greiner W., *Mikolajczyk R.T. (2016) Current and future effects of varicella and herpes

zoster vaccination in Germany - Insights from a mathematical model in a country with universal

varicella vaccination Human Vaccines and Immunotherapeutics 12: 1766 - 1776.

Kersting C., Lindemann C., *Mikolajczyk R., Garbe E., Riedel O. (2016) Optimizing ADHD Treatment?

Results of a Pilotstudy of the ADHD Selective Contract in Bremerhaven, Germany PPmP

Psychotherapie Psychosomatik Medizinische Psychologie 66: 187 - 194.

Kersting C., Lindemann C., Jacobi C., Lo Baido A., Schneider A., Yurdakul M., Ziegler-Kirbach E.,

*Mikolajczyk R., Garbe E. (2016) Therapy Goals for Children and Adolescents with ADHD and their

Primary CaregiversA Content Analysis and Examination of Agreement of ADHD Patients and their

Primary Caregivers Gesundheitswesen 78: 34 - 36.

*Mikolajczyk R.T., Sebena R., Warich J., Naydenova V., Dudziak U., Orosova O. (2016) Alcohol

drinking in university students matters for their self-rated health status: A cross-sectional study in

three European countries Frontiers in Public Health 4: 210.

*Mikolajczyk R.T., Zhang J., Grewal J., Chan L.C., Petersen A., Gross M.M. (2016) Early versus Late

Admission to Labor Affects Labor Progression and Risk of Cesarean Section in Nulliparous Women

Frontiers in Medicine 3: 26.

*Nguyen V.K., *Klawonn F., *Mikolajczyk R., *Hernandez-Vargas E.A. (2016) Analysis of practical

identifiability of a viral infection model PLoS ONE 11: e0167568.

https://www.ncbi.nlm.nih.gov/pubmed/?term=Brisson%20M%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=B%C3%A9nard%20%C3%89%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Drolet%20M%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Bogaards%20JA%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Baussano%20I%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=V%C3%A4nsk%C3%A4%20S%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Jit%20M%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Boily%20MC%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Smith%20MA%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Berkhof%20J%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Canfell%20K%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Chesson%20HW%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Burger%20EA%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Choi%20YH%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=De%20Blasio%20BF%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=De%20Vlas%20SJ%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Guzzetta%20G%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Hontelez%20JAC%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Horn%20J%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Jepsen%20MR%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Kim%20JJ%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Lazzarato%20F%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Matthijsse%20SM%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Mikolajczyk%20R%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Pavelyev%20A%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Pavelyev%20A%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Pillsbury%20M%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Shafer%20LA%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Tully%20SP%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Turner%20HC%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Usher%20C%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

https://www.ncbi.nlm.nih.gov/pubmed/?term=Walsh%20C%5BAuthor%5D&cauthor=true&cauthor_uid=29253379

45

Ohlmeier C., Czwikla J., Enders D., *Mikolajczyk R., Blindt R., Horenkamp-Sonntag D., Linder R., Garbe

E. (2016) Percutaneous coronary interventions: Use between 2004 and 2012 in Germany

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz : 1 - 6.

*Raupach-Rosin H., *Klett-Tammen C.J., Schmalz O., *Karch A., *Castell S., *Mikolajczyk R. (2016) “I

cannot kiss my wife”– An Analysis of Daily Experiences of MRSA-carriers Gesundheitswesen 78:

gesu513.

*Raupach-Rosin H., *Rübsamen N., Szkopek S., Schmalz O., *Karch A., *Mikolajczyk R., *Castell S.

(2016) Care for MRSA carriers in the outpatient sector: A survey among MRSA carriers and physicians

in two regions in Germany BMC Infectious Diseases 16: 184.

Schregel K., Behme D., Tsogkas I., Knauth M., Maier I., *Karch A., *Mikolajczyk R., Hinz J., Liman J.,

Psychogios M.-N. (2016) Effects of Workflow Optimization in Endovascularly Treated Stroke Patients -

A Pre-Post Effectiveness Study PLoS ONE 11: e0169192.

Ye J., Zhang J., *Mikolajczyk R., Torloni M.R., Gulmezoglu A.M., Betran A.P. (2016) Association

between rates of caesarean section and maternal and neonatal mortality in the 21st century: A

worldwide population-based ecological study with longitudinal data BJOG: An International Journal

of Obstetrics and Gynaecology 123: 745 - 753.



percentages in a web-based study, but in similar compliance International Journal of Public Health

60: 937 - 943.

*Akmatov M.K., Kimani-Murage E., *Pessler F., *Guzman C.A., *Krause G., Kreienbrock L.,



Betran A.P., Torloni M.R., Zhang J., Ye J., *Mikolajczyk R., Deneux-Tharaux C., Oladapo O.T., Souza

J.P., Tunçalp Ö., Vogel J.P., Gülmezoglu A.M. (2015) What is the optimal rate of caesarean section at

population level? A systematic review of ecologic studies Reproductive Health 12: 57.

Damm O., *Horn J., *Mikolajczyk R., Greiner W., Siedler A., Weidemann F., Wichmann O.,

Kretzschmar M., Ultsch B. (2015) Health Economic Evaluation of Different Vaccination Strategies

Against Varicella and Herpes Zoster in Germany Value in Health 18: A588.

Damm O., Ultsch B., *Horn J., *Mikolajczyk R.T., Greiner W., Wichmann O. (2015) Systematic review

of models assessing the economic value of routine varicella and herpes zoster vaccination in high-

income countries Health policies, systems and management in high-income countries BMC Public

Health 15: 533.

Gross M.M., Matterne A., Berlage S., Kaiser A., Lack N., Macher-Heidrich S., Misselwitz B., Bahlmann

F., Falbrede J., Hillemanns P., Von Kaisenberg C., Von Koch F.E., Schild R.L., Stepan H., Devane D.,

*Mikolajczyk R. (2015) Interinstitutional variations in mode of birth after a previous caesarean

46

section: A cross-sectional study in six German hospitals Journal of Perinatal Medicine 43: 177 - 184.

*Karch A., *Castell S., Schwab F., Geffers C., *Bongartz H., Brunkhorst F.M., Gastmeier P.,

*Mikolajczyk R.T. (2015) Proposing an empirically justified reference threshold for blood culture

sampling rates in intensive care units Journal of Clinical Microbiology 53: 648 - 652.

*Karch A., Schmitz R.P., Rißner F., *Castell S., Töpel S., Jakob M., Brunkhorst F.M., *Mikolajczyk R.T.

(2015) Bloodstream infections, antibiotic resistance and the practice of blood culture sampling in

Germany: study design of a Thuringia-wide prospective population-based study (AlertsNet) BMJ

Open 5: e009095.

Maier I.L., *Karch A., *Mikolajczyk R., Bahr M., Liman J. (2015) Effect of beta-blocker therapy on the

risk of infections and death after acute stroke - A historical cohort study PLoS ONE 10: e0116836.

McAlaney J., Helmer S.M., Stock C., Vriesacker B., Van Hal G., Dempsey R.C., Akvardar Y., Salonna F.,

Kalina O., Guillen-Grima F., Bewick B.M., *Mikolajczyk R. (2015) Personal and perceived peer use of

and attitudes toward alcohol among university and college students in seven EU countries: Project

SNIPE Journal of Studies on Alcohol and Drugs 76: 430 - 437.

*Mikolajczyk R., *Horn J., Schmedt N., Langner I., Lindemann C., Garbe E. (2015) Injury prevention by

medication among children with attention-deficit/Hyperactivity disorder a case-only study JAMA

Pediatrics 169: 391 - 395.

Ohlmeier C., *Mikolajczyk R., Frick J., Prutz F., Haverkamp W., Garbe E. (2015) Incidence, prevalence

and 1-year all-cause mortality of heart failure in Germany: a study based on electronic healthcare

data of more than six million persons Clinical Research in Cardiology 104: 688 - 696.

Ohlmeier C., Hoffmann F., Giersiepen K., Rothgang H., *Mikolajczyk R., Appelrat H.-J., Elsasser A.,

Garbe E. (2015) Linkage of statutory health insurance data with those of a hospital information

system: Feasible, but also useful? Gesundheitswesen 77: e8 - e14.

Ohlmeier C., Langner I., Hillebrand K., Schmedt N., *Mikolajczyk R., Riedel O., Garbe E. (2015)

Mortality in the German Pharmacoepidemiological Research Database (GePaRD) compared to

national data in Germany: Results from a validation study Biostatistics and methods BMC Public

Health 15: 570.

Pischke C.R., Helmer S.M., McAlaney J., Bewick B.M., Vriesacker B., Van Hal G., *Mikolajczyk R.T.,

Akvardar Y., Guillen-Grima F., Salonna F., Orosova O., Dohrmann S., Dempsey R.C., Zeeb H. (2015)

Normative misperceptions of tobacco use among university students in seven European countries:

Baseline findings of the 'Social Norms Intervention for the prevention of Polydrug usE' study

Addictive Behaviors 51: 158 - 164.

*Rübsamen N., *Castell S., *Horn J., *Karch A., *Ott J.J., *Raupach-Rosin H., *Zoch B., *Krause G.,

*Mikolajczyk R.T. (2015) Ebola risk perception in Germany, 2014 Emerging Infectious Diseases 21:

1012 - 1018.

*Schweitzer A., *Horn J., *Mikolajczyk R.T., *Krause G., *Ott J.J. (2015) Estimations of worldwide

prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965

47

and 2013 The Lancet 386: 1546 - 1555.

Zhang J., *Mikolajczyk R., Lei X., Sun L., Yu H., Cheng W. (2015) An adjustable fetal weight standard

for twins: A statistical modeling study BMC Medicine 13: 159.

*Zoch B., *Karch A., Dreesman J., Monazahian M., Baillot A., *Mikolajczyk R.T. (2015) Feasibility of a

birth cohort study dedicated to assessing acute infections using symptom diaries and parental

collection of biomaterials BMC Infectious Diseases 15: 436.

Hechtner M.C., Vogt T., Zollner Y., Schroder S., Sauer J.B., Binder H., Singer S., *Mikolajczyk R. (2014)

Quality of life in Parkinson's disease patients with motor fluctuations and dyskinesias in five

European countries Parkinsonism and Related Disorders 20: 969 - 974.

Helmer S.M., *Mikolajczyk R.T., McAlaney J., Vriesacker B., Van Hal G., Akvardar Y., Guillen-Grima F.,

Salonna F., Stock C., Dempsey R.C., Bewick B.M., Zeeb H. (2014) Illicit substance use among university

students from seven European countries: A comparison of personal and perceived peer use and

attitudes towards illicit substance use Preventive Medicine 67: 204 - 209.

Hense S., Hillebrand K., *Horn J., *Mikolajczyk R., Schulze-Rath R., Garbe E. (2014) HPV vaccine

uptake after introduction of the vaccine in Germany: An analysis of administrative data Human

Vaccines and Immunotherapeutics 10: 1729 - 1733.

*Mikolajczyk R.T., *Horn J., Prins M., Wiessing L., Kretzschmar M. (2014) Trajectories of injecting

behavior in the Amsterdam Cohort Study among drug users Drug and Alcohol Dependence 144: -

147.

Ohlmeier C., Frick J., Prutz F., Lampert T., Ziese T., *Mikolajczyk R., Garbe E. (2014) Use of routine

data from statutory health insurances for federal health monitoring purposes


Ohlmeier C., Linder R., Enders D., *Mikolajczyk R., Haverkamp W., Horenkamp-Sonntag D., Garbe E.

(2014) Evaluating methods for intersectoral comparison of quality of care: A routine data analysis of

elective percutaneous coronary interventions Methods of Information in Medicine 53: 269 - 277.

Stich H.L., Kramer A., *Mikolajczyk R.T. (2014) Clustering of developmental delays in Bavarian

preschool children - a repeated cross-sectional survey over a period of 12 years BMC Pediatrics 14:

18.

*Zoch B., *Mikolajczyk R. (2014) Infections in childhood Public Health Forum 22: 10.e1 - 10.e3.

*Horn J., Damm O., Kretzschmar M.E.E., Delere Y., Wichmann O., Kaufmann A.M., Garbe E., Kramer

A., Greiner W., *Mikolajczyk R.T. (2013) Estimating the long-term effects of HPV vaccination in

Germany Vaccine 31: 2372 - 2380.

Kraut A.A., Langner I., Lindemann C., Banaschewski T., Petermann U., Petermann F., *Mikolajczyk

R.T., Garbe E. (2013) Comorbidities in ADHD children treated with methylphenidate: A database

study BMC Psychiatry 13: 11.

48

Langner I., Garbe E., Banaschewski T., *Mikolajczyk R.T. (2013) Twin and Sibling Studies Using Health

Insurance Data: The Example of Attention Deficit/Hyperactivity Disorder (ADHD) PLoS ONE 8:

e62177.

*Mikolajczyk R., Kraut A., Garbe E. (2013) Evaluation of pregnancy outcome records in the German

pharmacoepidemiological research database (GePaRD) Pharmacoepidemiology and Drug Safety 22:

873 - 880.

*Mikolajczyk R.T., Kraut A.A., *Horn J., Schulze-Rath R., Garbe E. (2013) Changes in incidence of

anogenital warts diagnoses after the introduction of human papillomavirus vaccination in Germany-

an ecologic study Sexually Transmitted Diseases 40: 28 - 31.

*Mikolajczyk R.T., Schmedt N., Zhang J., Lindemann C., Langner I., Garbe E. (2013) Regional variation

in caesarean deliveries in Germany and its causes BMC Pregnancy and Childbirth 13: 99.

Ohlmeier C., *Mikolajczyk R., Haverkamp W., Garbe E. (2013) Incidence, prevalence, and

antithrombotic management of atrial fibrillation in elderly Germans Europace 15: 1437 - 1444.

Samkange-Zeeb F., *Mikolajczyk R.T., Zeeb H. (2013) Awareness and knowledge of sexually

transmitted diseases among secondary school students in two German cities Journal of Community

Health 38: 293 - 300.

49

Pieper, Dietmar

*Heidrich B., *Vital M., *Plumeier I., Döscher N., *Kahl S., Kirschner J., Ziegert S., Solbach P., Lenzen

H., Potthoff A., Manns M.P., Wedemeyer H., *Pieper D.H. (2018) Intestinal microbiota in patients

with chronic hepatitis C with and without cirrhosis compared with healthy controls Liver

International 38: 50 - 58.

*Akmatov M.K, *Koch N., *Vital M., Ahrens W., Flesch-Janys D., Fricke J., *Gatzemeier A., Greiser H.,

Günther K., Illig T., Kaaks R., Krone B., Kühn A., Linseisen J., Meisinger C., Michels K., Moebus S.,

Nieters A., Obi N., Schultze A., Six-Merker J., *Pieper D.H., *Pessler F. (2017). Determination of nasal

and oropharyngeal microbiomes in a multicenter population-based study - findings from Pretest 1 of

the German National Cohort. Sci Rep 7: 1855.

Amitay EL, Werner S, *Vital M, *Pieper DH, Höfler D, Gierse IJ, Butt J, Balavarca Y, Cuk K, Brenner H.

(2017) Fusobacterium and colorectal cancer: Causal factor or passenger? Results from a large

colorectal cancer screening study Carcinogenesis 38: 781 - 788.

*Arce-Rodríguez A., Puente-Sánchez F., Avendaño R., Libby E., Rojas L., Cambronero J.C., *Pieper

D.H., Timmis K.N., Chavarría M. (2017) Pristine but metal-rich Río Sucio (Dirty River) is dominated by

Gallionella and other iron-sulfur oxidizing microbes Extremophiles 21: 235 - 243.

*Babbar A., *Kumar V.N., *Bergmann R., *Barrantes I., *Pieper D.H., *Itzek A., *Nitsche-Schmitz D.P.

(2017) Members of a new subgroup of Streptococcus anginosus harbor virulence related genes

previously observed in Streptococcus pyogenes International Journal of Medical Microbiology 307:

174 - 181.

*Babbar A., *Nitsche-Schmitz D.P., *Pieper D.H., *Barrantes I. (2017) Draft genome sequence of

Streptococcus dysgalactiae subsp. equisimilis strain C161L1 isolated in Vellore, India Genome


De Weirdt R., Hernandez-Sanabria E., Fievez V., Mees E., Geirnaert A., Van Herreweghen F., Vilchez-

Vargas R., Van den Abbeele P., *Jauregui R., *Pieper D.H., Vlaeminck B., Van de Wiele T. (2017)

Mucosa-associated biohydrogenating microbes protect the simulated colon microbiome from stress

associated with high concentrations of poly-unsaturated fat Environmental Microbiology 19: 722 -

739.

*Duarte M., *Nielsen A., *Camarinha-Silva A., *Vilchez-Vargas R., Bruls T., *Wos-Oxley M.L.,

*Jauregui R., *Pieper D.H. (2017) Functional soil metagenomics: Elucidation of polycyclic aromatic

hydrocarbon degradation potential following 12 years of in situ bioremediation Environmental


*Gottschick C, *Deng ZL, *Vital M, Masur C, Abels C, *Pieper DH, *Rohde M, Mendling W, *Wagner-

Döbler I. (2017) Treatment of biofilms in bacterial vaginosis by an amphoteric tenside pessary-clinical

study and microbiota analysis Microbiome 5: 119.

*Gottschick C, *Deng ZL, *Vital M, Masur C, Abels C, *Pieper DH, *Wagner-Döbler I. (2017) The

urinary microbiota of men and women and its changes in women during bacterial vaginosis and

antibiotic treatment Microbiome 5: 99.

50

Lopez-Fernandez M., Vilchez-Vargas R., Jroundi F., Boon N., *Pieper D., Merroun M.L. (2017)

Microbial community changes induced by uranyl nitrate in bentonite clay microcosms Applied Clay

Science Article in Press.

Marzorati M., Vilchez-Vargas R., Bussche J.V., Truchado P., *Jauregui R., El Hage R.A., *Pieper D.H.,

Vanhaecke L., Van de Wiele T. (2017) High-fiber and high-protein diets shape different gut microbial

communities, which ecologically behave similarly under stress conditions, as shown in a

gastrointestinal simulator Molecular Nutrition & Food Research 61: 1600150.

*Milici M., *Vital M., *Tomasch J., Badewien T.H., Giebel H.A., *Plumeier I., Wang H., *Pieper D.H.,

*Wagner-Döbler I., Simon, M. (2017) Diversity and community composition of particle‐associated

and free‐living bacteria in mesopelagic and bathypelagic Southern Ocean water masses: Evidence of

dispersal limitation in the Bransfield Strait. Limnology and Oceanography 62: 1080 - 1095.

*Rath S, *Heidrich B, *Pieper DH, *Vital M. (2017) Uncovering the trimethylamine-producing bacteria

of the human gut microbiota Microbiome 5: 54.

Ruiz A., Cerdó T., *Jáuregui R., *Pieper D.H., Marcos A., Clemente A., García F., Margolles A., Ferrer

M., Campoy C., Suárez A. (2017) One-year calorie restriction impacts gut microbial composition but

not its metabolic performance in obese adolescents Environmental Microbiology 19: 1536 - 1551.

Salden B.N., Troost F.J., Wilms E., Truchado P., Vilchez-Vargas R., *Pieper D.H., *Jáuregui R.,

Marzorati M., van de Wiele T., Possemiers S., Masclee A.A. (2017) Reinforcement of intestinal

epithelial barrier by Arabinoxylans in overweight and obese subjects: A randomized controlled trial.

Arabinoxylans in gut barrier Clinical Nutrition pii: S0261-5614(17)30048-1. doi:

10.1016/j.clnu.2017.01.024.

*Schulz C., Schütte K., *Koch N., Vilchez-Vargas R., *Wos-Oxley M.L., *Oxley A.P.A., *Vital M.,

Malfertheiner P., *Pieper D.H. (2017) The active bacterial assemblages of the upper GI tract in

individuals with and without Helicobacter infection Gut 67: 216-225.

Truchado P., Hernandez-Sanabria E., Salden B.N., Van den Abbeele P., Vilchez-Vargas R., *Jauregui R.,

*Pieper D.H., Possemiers S., Van de Wiele T. (2017) Long chain Arabinoxylans shift the mucosa-

associated microbiota in the proximal colon of the simulator of the human intestinal microbial

ecosystem (M-SHIME) Journal of Functional Foods 32: 226 - 237.

Van den Bossche L., Hindryckx P., Devisscher L., Devriese S., Van Welden S., Holvoet T., Vilchez-

Vargas R., *Vital M., *Pieper D.H., Bussche J.V., Vanhaecke L., Van de Wiele T., De Vos M., Laukens D.

(2017) Ursodeoxycholic acid and its taurine- or glycine-conjugated species reduce colitogenic

dysbiosis and equally suppress experimental colitis in mice Applied and Environmental Microbiology

83: e02766-16.

Van Herreweghen F., Van den Abbeele P., De Mulder T., De Weirdt R., Geirnaert A., Hernandez-

Sanabria E., Vilchez-Vargas R., *Jauregui R., Pieper D.H., Belzer C., De Vos W.M., Van de Wiele T.

(2017) In vitro colonisation of the distal colon by Akkermansia muciniphila is largely mucin and pH

dependent Beneficial Microbes 8: 81 - 96.

Vital M, Karch A, Pieper DH. (2017) Colonic butyrate-producing communities in humans: an overview

51

using omics data mSystems 2: pii: e00130-17.

Witte T., *Pieper D.H., Heidrich B. (2017) Intestinal microbiota in individualized therapies Internist

58: 682 - 686.

*Chaves-Moreno D., *Wos-Oxley M.L., *Jáuregui R., *Medina E., *Oxley A.P.,* Pieper D.H. (2016)

Exploring the transcriptome of Staphylococcus aureus in its natural niche Scientific Reports 6: 33174.

Coma M., Vilchez-Vargas R., Roume H., *Jauregui R., *Pieper D.H., Rabaey K. (2016) Product diversity

linked to substrate usage in chain elongation by mixed-culture fermentation Environmental Science

and Technology 50: 6467 - 6476.

Courtens E.N., Spieck E., Vilchez-Vargas R., Bodé S., Boeckx P., Schouten S., *Jauregui R., *Pieper

D.H., Vlaeminck S.E., Boon N. (2016) A robust nitrifying community in a bioreactor at 50 °c opens up

the path for thermophilic nitrogen removal ISME Journal 10: 2293 - 2303.

Courtens E.N.P., Vandekerckhove T., Prat D., Vilchez-Vargas R., *Vital M., *Pieper D.H., Meerbergen

K., Lievens B., Boon N., Vlaeminck S.E. (2016) Empowering a mesophilic inoculum for thermophilic

nitrification: Growth mode and temperature pattern as critical proliferation factors for archaeal

ammonia oxidizers Water Research 92: 94 - 103.

De Vrieze J., Raport L., Roume H., Vilchez-Vargas R., *Jáuregui R., *Pieper D.H., Boon N. (2016) The

full-scale anaerobic digestion microbiome is represented by specific marker populations Water

Research 104: 101 - 110.

De Vrieze J., Regueiro L., Props R., Vilchez-Vargas R., *Jauregui R., *Pieper D.H., Lema J.M., Carballa

M. (2016) Presence does not imply activity: DNA and RNA patterns differ in response to salt

perturbation in anaerobic digestion Biotechnology for Biofuels 9: 244.

Ehsani E., *Barrantes I., Vandermaesen J., *Geffers R., *Jarek M., Boon N., Springael D., *Pieper D.H.,

Vilchez-Vargas R. (2016) Draft genome sequence of Aeromonas sp. strain EERV15 Genome


*Gálvez E.J., Carrillo-Castro K., Zárate L., Güiza L., *Pieper D.H., García-Bonilla E., Salazar M., Junca H.

(2016) Draft genome sequence of Bacillus licheniformis CG-B52, a highly virulent bacterium of Pacific

white shrimp (Litopenaeus vannamei), isolated from a Colombian Caribbean aquaculture outbreak

Genome Announcements 4: e00321-16.

Giuliani C., Marzorati M., Innocenti M., Vilchez-Vargas R., *Vital M., *Pieper D.H., Van De Wiele T.,

Mulinacci N. (2016) Dietary supplement based on stilbenes: A focus on gut microbial metabolism by

the: In vitro simulator M-SHIME(r) Food and Function 7: 4564 - 4575.

Grunert O., Hernandez-Sanabria E., Vilchez-Vargas R., *Jauregui R., *Pieper D.H., Perneel M., Van

Labeke M.-C., Reheul D., Boon N. (2016) Mineral and organic growing media have distinct community

structure, stability and functionality in soilless culture systems Scientific Reports 6: 18837.

*Heidrich B., *Steinmann E., *Plumeier I., Kirschner J., Sollik L., Ziegert S., *Engelmann M., Lehmann

P., Manns M.P., *Pieper D.H., Wedemeyer H. (2016) Frequent detection of HCV RNA and HCVcoreAg

52

in stool of patients with chronic hepatitis C Journal of Clinical Virology 80: 1 - 7.

Kaspar U., Kriegeskorte A., Schubert T., Peters G., Rudack C., *Pieper D.H., *Wos-Oxley M., Becker K.

(2016) The culturome of the human nose habitats reveals individual bacterial fingerprint patterns


Lima-Morales D.*, *Jáuregui R., *Camarinha-Silva A., *Geffers R., *Pieper D.H., *Vilchez-Vargas R.

(2016) Linking microbial community and catabolic gene structures during the adaptation of three

contaminated soils under continuous long-term pollutant stress Applied and Environmental


Lünsmann V., Kappelmeyer U., Benndorf R., Martinez-Lavanchy P.M., Taubert A., Adrian L., *Duarte

M., *Pieper D.H., von Bergen M., Müller J.A., Heipieper H.J., Jehmlich N. (2016) In situprotein-SIP

highlights Burkholderiaceae as key players degrading toluene by para ring hydroxylation in a

constructed wetland model Environmental Microbiology 18: 1176 - 1186.

Maes S., Props R., Fitts J.P., De Smet R., Vilchez-Vargas R., *Vital M., *Pieper D.H., Vanhaecke F.,

Boon N., Hennebel T. (2016) Platinum recovery from synthetic extreme environments by halophilic

bacteria Environmental Science and Technology 50: 2619 - 2626.

*Medina E., *Pieper D.H. (2016) Tackling threats and future problems of multidrug-resistant bacteria


Meerburg F.A., Vlaeminck S.E., Roume H., Seuntjens D., *Pieper D.H., *Jauregui R., Vilchez-Vargas R.,

Boon N. (2016) High-rate activated sludge communities have a distinctly different structure

compared to low-rate sludge communities, and are less sensitive towards environmental and

operational variables Water Research 100: 137 - 145.

*Milici M., *Deng Z.L., *Tomasch J., Decelle J., *Wos-Oxley M.L., *Wang H., *Jáuregui R., *Plumeier I.,

Giebel H.A., Badewien T.H., Wurst M., *Pieper D.H., Simon M., *Wagner-Döbler I. (2016) Co-

occurrence analysis of microbial taxa in the Atlantic ocean reveals high connectivity in the free-living

bacterioplankton Frontiers in Microbiology 7: 649.

*Milici M., *Tomasch J., *Wos-Oxley M.L., *Wang H., *Jáuregui R., *Camarinha-Silva A., *Deng Z.-L.,

*Plumeier I., Giebel H.-A., Wurst M., *Pieper D.H., Simon M., *Wagner-Döbler I. (2016) Low diversity

of planktonic bacteria in the tropical ocean Scientific Reports 6: 1 - 9.

*Milici M., *Tomasch J., *Wos-Oxley M.L., Decelle J., *Jáuregui R., *Wang H., *Deng Z.-L., *Plumeier

I., Giebel H.-A., Badewien T.H., Wurst M., *Pieper D.H., Simon M., *Wagner-Döbler I. (2016)

Bacterioplankton biogeography of the Atlantic ocean: A case study of the distance-decay relationship


Puente-Sánchez F., *Pieper D.H., *Arce-Rodríguez A. (2016) Draft genome sequence of the deep-

subsurface actinobacterium Tessaracoccus lapidicaptus IPBSL-7T Genome Announcements 4:

e01078-16.

Stallmach A., Lange K., Buening J., Sina C., *Vital M., *Pieper D.H. (2016) Fecal microbiota transfer in

patients with chronic antibiotic-refractory pouchitis American Journal of Gastroenterology 111: 441

53

- 443.

Verstraelen H., Vilchez-Vargas R., Desimpel F., *Jauregui R., Vankeirsbilck N., Weyers S., Verhelst R.,

Sutter P.D., *Pieper D.H., De Wiele T.V. (2016) Characterisation of the human uterine microbiome in

non-pregnant women through deep sequencing of the V1-2 region of the 16S rRNA gene PeerJ 2016:

e1602.

*Wos-Oxley M.L., *Chaves-Moreno D., *Jáuregui R., *Oxley A.P.A., Kaspar U., *Plumeier I., *Kahl S.,

Rudack C., Becker K., *Pieper D.H. (2016) Exploring the bacterial assemblages along the human nasal

passage Environmental Microbiology 18: 2259 - 2271.

Yakimov M.M., Crisafi F., Messina E., Smedile F., Lopatina A., Denaro R., *Pieper D.H., Golyshin P.N.,

Giuliano L. (2016) Analysis of defence systems and a conjugative IncP-1 plasmid in the marine

polyaromatic hydrocarbons-degrading bacterium Cycloclasticus sp. 78-ME Environmental

Microbiology Reports 8: 508 - 519.

*Chaves-Moreno D., *Plumeier I., *Kahl S., Krismer B., Peschel A., *Oxley A.P.A., *Jauregui R., *Pieper

D.H. (2015) The microbial community structure of the cotton rat nose Environmental Microbiology

Reports 7: 929 - 935.

*Chaves-Moreno D., *Wos-Oxley M.L., *Jáuregui R., *Medina E., *Oxley A.P.A., *Pieper D.H. (2015)

Application of a novel "Pan-genome"-based strategy for assigning RNAseq transcript reads to

Staphylococcus aureus strains PLoS ONE 10: e0145861.

*de Lima-Morales D., *Chaves-Moreno D., *Wos-Oxley M.L., *Jáuregui R., *Vilchez-Vargas R., *Pieper

D.H. (2015) Degradation of benzene by Pseudomonas veronii 1YdBTEX2 and 1YB2 is catalyzed by

enzymes encoded in distinct catabolism gene clusters Applied and Environmental Microbiology 82:

167 - 173.

*Schulz C., *Koch N., Schutte K., *Pieper D.H., Malfertheiner P. (2015) H.pylori and its modulation of

gastrointestinal microbiota Journal of Digestive Diseases 16: 109 - 117.

*Szafranski S.P., *Wos-Oxley M.L., *Vilchez-Vargas R., *Jauregui R., *Plumeier I., *Klawonn F.,

*Tomasch J., Meisinger C., Kuhnisch J., *Sztajer H., *Pieper D.H., *Wagner-Dobler I. (2015) High-

resolution taxonomic profiling of the subgingival microbiome for biomarker discovery and

periodontitis diagnosis Applied and Environmental Microbiology 81: 1047 - 1058.

Burbach K., Seifert J., *Pieper D.H., Camarinha-Silva A. (2015) Evaluation of DNA extraction kits and

phylogenetic diversity of the porcine gastrointestinal tract based on Illumina sequencing of two

hypervariable regions MicrobiologyOpen 5: 70 - 82.

De Vrieze J., Gildemyn S., Vilchez-Vargas R., *Jauregui R., *Pieper D.H., Verstraete W., Boon N. (2015)

Inoculum selection is crucial to ensure operational stability in anaerobic digestion Applied

Microbiology and Biotechnology 99: 189 - 199.

Ehsani E., *Jauregui R., *Geffers R., *Jareck M., Boon N., *Pieper D.H., Vilchez-Vargas R. (2015) Draft

genome sequence of Rhodococcus sp. strain 311R Genome Announcements 3: e00378-15.

54

Ehsani E., *Jauregui R., *Geffers R., *Jarek M., Boon N., *Pieper D.H., Vilchez-Vargas R. (2015) First

draft genome sequence of the Acidovorax caeni sp. nov. type strain R-24608 (DSM 19327) Genome


Korsch M., Marten S.-M., Dötsch A., *Jáuregui R., *Pieper D.H., Obst U. (2015) Effect of dental

cements on peri-implant microbial community: comparison of the microbial communities inhabiting

the peri-implant tissue when using different luting cements Clinical Oral Implants Research 27: e161

- e166.

Kümmel S., Herbst F.A., Bahr A., *Duarte M., *Pieper D.H., Jehmlich N., Seifert J., von Bergen M.,

Bombach P., Richnow H.H., Vogt C. (2015) Anaerobic naphthalene degradation by sulfatereducing

Desulfobacteraceae from various anoxic aquifers FEMS Microbiology Ecology 91: fiv006.

Lassek C., Burghartz M., *Chaves-Moreno D., Otto A., Hentschker C., Fuchs S., Bernhardt J., *Jauregui

R., Neubauer R., Becher D., *Pieper D.H., Jahn M., Jahn D., *Riedel K. (2015) A metaproteomics

approach to elucidate host and pathogen protein expression during catheter-associated urinary tract

infections (CAUTIs) Molecular and Cellular Proteomics 14: 989 - 1008.

Lopez-Fernandez M., Cherkouk A., Vilchez-Vargas R., *Jauregui R., *Pieper D., Boon N., Sanchez-

Castro I., Merroun M.L. (2015) Bacterial diversity in bentonites, engineered barrier for deep

geological disposal of radioactive wastes Microbial Ecology 70: 922 - 935.

Martínez-Lavanchy P.M., Chen Z., Lünsmann V., Marin-Cevada V., *Vilchez-Vargas R., *Pieper D.H.,

Reiche N., Kappelmeyer U., Imparato V., Junca H., Nijenhuis I., Müller J.A., Kuschk P., Heipieper H.J.

(2015) Microbial toluene removal in hypoxic model constructed wetlands occurs predominantly via

the ring monooxygenation pathway Applied and Environmental Microbiology 81: 6241 - 6252.

Perez-Pantoj D., Leiva-Novoa P., Donoso R.A., Little C., Godoy M., *Pieper D.H., Gonzalez B. (2015)

Hierarchy of carbon source utilization in soil bacteria: Hegemonic preference for benzoate in complex

aromatic compound mixtures degraded by Cupriavidus pinatubonensis strain JMP134 Applied and


*Camarinha-Silva A., *Jauregui R., *Chaves-Moreno D., *Oxley A.P., Schaumburg F., Becker K., *Wos-

Oxley M.L., *Pieper D.H. (2014) Comparing the anterior nare bacterial community of two discrete

human populations using Illumina amplicon sequencing Environmental Microbiology 16: 2939 -

2952.

Courtens E.N.P., Vlaeminck S.E., Vilchez-Vargas R., Verliefde A., *Jauregui R., *Pieper D.H., Boon N.

(2014) Trade-off between mesophilic and thermophilic denitrification: Rates vs. sludge production,

settleability and stability Water Research 63: 234 - 244.

*Duarte M., *Jauregui R., *Vilchez-Vargas R., *Junca H., *Pieper D.H. (2014) AromaDeg, a novel

database for phylogenomics of aerobic bacterial degradation of aromatics Database : the journal of

biological databases and curation 2014: bau118.

Gomez-Silvan C., *Vilchez-Vargas R., Arevalo J., Gomez M.A., Gonzalez-Lopez J., *Pieper D.H., Rodelas

B. (2014) Quantitative response of nitrifying and denitrifying communities to environmental variables

in a full-scale membrane bioreactor Bioresource Technology 169: 126 - 133.

55

*Jauregui R., Rodelas B., *Geffers .R, Boon N., *Pieper D.H., Vilchez-Vargas R. (2014) Draft genome

sequence of the naphthalene degrader Herbaspirillum sp. strain RV1423 Genome Announcements 2:

e00188-14.

Kerckhof F.-M., Courtens E.N.P., Geirnaert A., Hoefman S., Ho A., Vilchez-Vargas R., *Pieper D.H.,

*Jauregui R., Vlaeminck S.E., Van De Wiele T., Vandamme P., Heylen K., Boon N. (2014) Optimized

cryopreservation of mixed microbial communities for conserved functionality and diversity PLoS ONE

9: e99517.

*Mehraj J., *Akmatov M.K., *Strompl J., *Gatzemeier A., Layer F., Werner G., *Pieper D.H., *Medina




*Szafranska A.K., *Oxley A.P.A., *Chaves-*Moreno D., *Horst S.A., Rosslenbroich S., Peters G.,

*Goldmann O., *Rohde M., Sinha B., *Pieper D.H., Loffler B., *Jauregui R., *Wos-Oxley M.L., *Medina

E. (2014) High-resolution transcriptomic analysis of the adaptive response of Staphylococcus aureus

during acute and chronic phases of osteomyelitis mBio 5: e01775-14.

*de Lima-Morales D., *Chaves-Moreno D., *Jarek M., *Vilchez-Vargas R., *Jauregui R., *Pieper D.H.

(2013) Draft genome sequence of Pseudomonas veronii strain 1YdBTEX2 Genome Announcements 1:

e00258-13.

Alcaide M., Tornes J., Stogios P.J., Xu X., Gertler C., Leo R.D.I., Bargiela R., Lafraya A., Guazzaroni M.-

E., Lopez-Cortes N., Chernikova T.N., Golyshina O.V., Nechitaylo T.Y., *Plumeier I., *Pieper D.H.,

Yakimov M.M., Savchenko A., Golyshin P.N., Ferrer (2013) Single residues dictate the co-evolution of

dual esterases: MCP hydrolases from the α/β hydrolase family Biochemical Journal 454: 157 - 166.

De Lorenzo V., *Pieper D., Ramos J.L. (2013) From the test tube to the environment-and back


Guazzaroni M.-E., Herbst F.-A., Lores I., Tamames J., Pelaez A.I., Lopez-Cortes N., Alcaide M., Del Pozo

M.V., Vieites J.M., von Bergen M., Gallego J.L.R., Bargiela R., Lopez-Lopez A., *Pieper D.H., Rossello-

Mora R., Sanchez J., Seifert J., Ferrer M. (2013) Metaproteogenomic insights beyond bacterial

response to naphthalene exposure and bio-stimulation ISME Journal 7: 122 - 136.

Herbst F.-A., Bahr A., *Duarte M., *Pieper D.H., Richnow H.-H., von Bergen M., Seifert J., Bombach P.

(2013) Elucidation of in situ polycyclic aromatic hydrocarbon degradation by functional

metaproteomics (protein-SIP) Proteomics 13: 2910 - 2920.

Oosterkamp M.J., Veuskens T., Talarico Saia F., Weelink S.A.B., Goodwin L.A., Daligault H.E., Bruce

D.C., Detter J.C., Tapia R., Han C.S., Land M.L., Hauser L.J., Langenhoff A.A.M., Gerritse J., van Berkel

W.J.H., *Pieper D.H., Junca H., Smidt H., Schraa G., Davids M., Schaap P.J., Plugge C.M., Stams A.J.

(2013) Genome analysis and physiological comparison of Alicycliphilus denitrificans strains BC and

K601T PLoS ONE 8: e66971.

Schmidt E., Mandt C., Janssen D.B., *Pieper D.H., Reineke W. (2013) Degradation of chloroaromatics:

56

Structure and catalytic activities of wild-type chlorocatechol 2,3-dioxygenases and modified ones


*Vilchez-Vargas R., *Geffers R., *Suarez-Diez M., *Conte I., *Waliczek A., *Kaser V.S., Kralova M.,

*Junca H., *Pieper D.H. (2013) Analysis of the microbial gene landscape and transcriptome for

aromatic pollutants and alkane degradation using a novel internally calibrated microarray system


57

Pietschmann, Thomas

*Bankwitz D., *Doepke M., *Hueging K., *Weller R., *Bruening J., *Behrendt P., Lee J.-Y., Vondran

F.W.R., Manns M.P., Bartenschlager R., *Pietschmann T. (2017) Maturation of secreted HCV particles

by incorporation of secreted ApoE protects from antibodies by enhancing infectivity Journal of


Bartenschlager R., Cornberg M., *Pietschmann T. (2017) Personalized treatment of viral hepatitis of

the present and the future: Hepatitis B, C, delta, and E Internist 58: 666 - 674.

*Behrendt P., *Perin P., *Menzel N., *Banda D., Pfaender S., Alves M.P., Thiel V., Meulemann P.,

Colpitts C.C., Schang L.M., Vondran F.W.R., Anggakusuma, Manns M.P., *Steinmann E., *Pietschmann

T. (2017) Pentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex

moutan, efficiently blocks hepatitis C virus entry Antiviral Research 147: 19 - 28.

*Gerold G., *Bruening J., *Weigel B., *Pietschmann T. (2017) Protein interactions during the

Flavivirus and hepacivirus life cycle Molecular and Cellular Proteomics 16: S75 - S91.

*Khera T., *Todt D., Vercauteren K., McClure C.P., Verhoye L., Farhoudi A., *Bhuju S., *Geffers R.,

Baumert T.F., *Steinmann E., Meuleman P., Meuleman P., Baumert T.F., Baumert T.F.,

*Pietschmann T., *Brown R.J.P. (2017) Tracking HCV protease population diversity during

transmission and susceptibility of founder populations to antiviral therapy Antiviral Research 139:

129 - 137.

*Pietschmann T. (2017) Clinically approved ion channel inhibitors close gates for hepatitis C virus and

open doors for drug repurposing in infectious viral diseases Journal of Virology 91: e01914-16.

Riber C.F., Andersen A.H.F., Rolskov Læ.A., Zuwala K., Gajda P., Løvschall K.B., Dagnæs-Hansen F.,

*Banda D.H., *Pietschmann T., Tolstrup M., Zelikin A.N. (2017) Synthetic Polymer with a Structure-

Driven Hepatic Deposition and Curative Pharmacological Activity in Hepatic Cells ACS Macro Letters

6: 935 - 940.

*Siddharta A., Pfaender S., Vielle N.J., Dijkman R., *Friesland M., Becker B., Yang J., *Engelmann M.,

*Todt D., Windisch M.P., Brill F.H., Steinmann J., Steinmann J., Becker S., Alves M.P., *Pietschmann

T., Eickmann M., Thiel V., *Steinmann E. (2017) Virucidal activity of world health organization-

recommended formulations against enveloped viruses, including zika, ebola, and emerging

coronaviruses Journal of Infectious Diseases 215: 902 - 906.

Vasiliauskaite I., Owsianka A., England P., Khan A.G., Cole S., Bankwitz D., Foung S.K.H., *Pietschmann

T., Marcotrigiano J., Rey F.A., Patel A.H., Krey T. (2017) Conformational flexibility in the

immunoglobulin-like domain of the hepatitis C virus glycoprotein E2 mBio 8: e00382-17.

*Weller R., *Hueging K., *Brown R.J.P., *Todt D., *Joecks S., Vondran F.W.R., *Pietschmann T. (2017)

Hepatitis C virus strain-dependent usage of apolipoprotein E modulates assembly efficiency and

specific infectivity of secreted virions Journal of Virology 91: e00422-17.

*Anggakusuma, *Brown R.J.P., *Banda D.H., *Todt D., *Vieyres G., *Steinmann E., *Pietschmann T.

(2016) Hepacivirus NS3/4A proteases interfere with MAVS signaling in both their cognate animal

hosts and humans: Implications for zoonotic transmission Journal of Virology 90: 10670 - 10681.

58

*Gerold G., *Bruening J.,*Pietschmann T. (2016) Decoding protein networks during virus entry by

quantitative proteomics Virus Research 218: 25 - 39.

*Haid S., *Grethe C., *Bankwitz D., Grunwald T., *Pietschmann T. (2016) Identification of a human

respiratory syncytial virus cell entry inhibitor by using a novel lentiviral pseudotype system Journal of

Virology 90: 3065 - 3073.

*Pfaender S., *Grabski E., *Detje C.N., *Riebesehl N., *Lienenklaus S., *Steinmann E., *Kalinke U.,

*Pietschmann T. (2016) Hepatitis C Virus Stimulates Murine CD8a-Like Dendritic Cells to Produce

Type I Interferon in a TRIF-Dependent Manner PLoS Pathogens 12: e1005736.

*Todt D., François C., *Anggakusuma, *Behrendt P., *Engelmann M., *Knegendorf L., *Vieyres G.,

Wedemeyer H., Hartmann R., *Pietschmann T., Duverlie G., *Steinmann E. (2016) Antiviral activities

of different interferon types and subtypes against Hepatitis E virus replication Antimicrobial Agents

and Chemotherapy 60: 2132 - 2139.

*Vieyres G., *Welsch K., *Gerold G., *Gentzsch J., *Kahl S., Vondran F.W.R., Kaderali L.,

*Pietschmann T. (2016) ABHD5/CGI-58, the Chanarin-Dorfman Syndrome Protein, Mobilises Lipid

Stores for Hepatitis C Virus Production PLoS Pathogens 12: e1005568.

von Schaewen M., Dorner M., *Hueging K., Foquet L., Gerges S., Hrebikova G., Heller B., *Bitzegeio J.,

*Doerrbecker J., Horwitz J.A., *Gerold G., Suerbaum S., Rice C.M., Meuleman P., *Pietschmann T.,

Ploss A. (2016) Expanding the host range of hepatitis C virus through viral adaptation mBio 7:

e01915-16.

Walker A., Skibbe K., *Steinmann E., *Pfaender S., Kuntzen T., Megger D.A., Groten S., Sitek B., Lauer

G.M., Kim A.Y., *Pietschmann T., Allen T.M., Timm J. (2016) Distinct escape pathway by hepatitis C

virus genotype 1a from a dominant CD8+ T cell response by selection of altered epitope processing

Journal of Virology 90: 33 - 42.

*Walter S., *Bollenbach A., *Doerrbecker J., *Pfaender S., *Brown R.J.P., *Vieyres G., Scott C., Foster

R., Kumar A., Zitzmann N., Griffin S., Penin F., *Pietschmann T., *Steinmann E. (2016) Ion channel

function and cross-species determinants in viral assembly of nonprimate hepacivirus p7 Journal of

Virology 90: 5075 - 5089.

*Weller R., *Todt D., *Engelmann M., *Friesland M., Wedemeyer H., *Pietschmann T., *Steinmann E.

(2016) Apolipoprotein E polymorphisms and their protective effect on hepatitis E virus replication

Hepatology 64: 2274 - 2276.





*Abd-Elshafy D., *Pietschmann T., Muller-Ladner U., Neumann E., *Anggakusuma, *Bahgat M.M,

*Pessler F., *Behrendt P. (2015) Cell culture-derived HCV cannot infect synovial fibroblasts Scientific

Reports 5: 18043.

59

*Anggakusuma, *Frentzen A., Gurlevik E., *Yuan Q., *Steinmann E., *Ott M., Staeheli P., Schmid-

Burgk J., Schmidt T., Hornung V., Kuehnel F., *Pietschmann T. (2015) Control of hepatitis C virus

replication in mouse liver-derived cells by MAVS-dependent production of type I and type III

interferons Journal of Virology 89: 3833 - 3845.

*Anggakusuma., Romero-Brey I., Berger C., Colpitts C.C., Boldanova T., *Engelmann M., *Todt D.,

*Perin P.M., *Behrendt P., Vondran F.W., Xu S., *Goffinet C., Schang L.M., Heim M.H., Bartenschlager

R., *Pietschmann T., *Steinmann E. (2015) Interferon-inducible cholesterol-25-hydroxylase restricts

hepatitis C virus replication via blockage of membranous web formation Hepatology 62: 702 - 714.

*Gerold G., Meissner F., *Bruening J., *Welsch K., *Perin P.M., Baumert T.F., Vondran F.W., Kaderali

L., Marcotrigiano J., Khan A.G., Mann M., Rice C.M., *Pietschmann T. (2015) Quantitative Proteomics

Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus Entry Cell

Reports 12: 864 - 878.

*Grabski E., *Wappler I., *Pfaender S., *Steinmann E., *Haid S., Dzionek A., *Pietschmann T.,

*Kalinke U. (2015) Efficient virus assembly, but not infectivity, determines the magnitude of hepatitis

C virus-induced interferon alpha responses of plasmacytoid dendritic cells Journal of Virology 89:

3200 - 3208.

Hedenstierna M., Weiland O., Brass A., *Bankwitz D., *Behrendt P., Uhnoo I., Aleman S., Cardell K.,

Fryden A., Norkrans G., Eilard A., Glaumann H., *Pietschmann T., Sallberg M., Brenndorfer E.D. (2015)

Long-term follow-up of successful hepatitis C virus therapy: Waning immune responses and

disappearance of liver disease are consistent with cure Alimentary Pharmacology and Therapeutics

41: 532 - 543.

*Hueging K., *Weller R., *Doepke M., *Vieyres G., *Todt D., Wölk B., Vondran F.W.R., *Geffers R.,

Lauber C., Kaderali L., Penin F., *Pietschmann T. (2015) Several human liver cell expressed

apolipoproteins complement HCV virus production with varying efficacy conferring differential

specific infectivity to released viruses PLoS ONE 10: e0134529.

Koutsoudakis G., Romero-Brey I., Berger C., Perez-Vilaro G., *Monteiro Perin P., Vondran F.W.R.,

*Kalesse M., *Harmrolfs K., *Muller R., Martinez J.P., *Pietschmann T., Bartenschlager R., *Brönstrup

M., Meyerhans A., Diez J. (2015) Soraphen A: A broad-spectrum antiviral natural product with potent

anti-hepatitis C virus activity Journal of Hepatology 63: 813 - 821.

Lauber C., *Vieyres G., Terczynska-Dyla E., *Anggakusuma, Dijkman R., Gad H.H., Akhtar H., *Geffers

R., Vondran F.W., Thiel V., Kaderali L., *Pietschmann T., Hartmann R. (2015) Transcriptome analysis

reveals a classical interferon signature induced by IFNλ4 in human primary cells Genes and Immunity

16: 414 - 421.

Lump E., Castellano L.M., Meier C., Seeliger J., Erwin N., Sperlich B., Sturzel C.M., Usmani S.,

Hammond R.M., Von Einem J., *Gerold G., Kreppel F., Bravo-Rodriguez K., *Pietschmann T., Holmes

V.M., Palesch D., Zirafi O., Weissman D., Sowislok A., Wettig (2015) A molecular tweezer antagonizes

seminal amyloids and HIV infection eLife 4: e05397.

*Pfaender S., *Brinkmann J., *Todt D., *Riebesehl N., Steinmann J., Steinmann J., *Pietschmann T.,

60

*Steinmann E. (2015) Mechanisms of methods for hepatitis C virus inactivation Applied and


*Pfaender S., *Walter S., *Todt D., *Behrendt P., *Doerrbecker J., Wolk B., *Engelmann M.,

Gravemann U., Seltsam A., Steinmann J., Burbelo P.D., *Klawonn F., Feige K., *Pietschmann T.,

Cavalleri J.-M.V., *Steinmann E. (2015) Assessment of cross-species transmission of hepatitis C virus-

related non-primate hepacivirus in a population of humans at high risk of exposure Journal of

General Virology 96: 2636 - 2642.

*Pfaender S., Cavalleri J.M., *Walter S., *Doerrbecker J., Campana B., *Brown R.J., Burbelo P.D.,

Postel A., Hahn .K, *Anggakusuma, *Riebesehl N., Baumgärtner W., Becher P., Heim M.H.,

*Pietschmann T., Feige K., *Steinmann E. (2015) Clinical course of infection and viral tissue tropism of

hepatitis C virus-like nonprimate hepaciviruses in horses Hepatology 61: 447 - 459.

Tarr A.W., *Khera T., *Hueging K., *Sheldon J., *Steinmann E., *Pietschmann T., *Brown R.J.P. (2015)

Genetic diversity underlying the envelope glycoproteins of hepatitis C virus: Structural and functional

consequences and the implications for vaccine design Viruses 7: 3995 - 4046.

Vercauteren K., *Brown R.J.P., Mesalam A.A., *Doerrbecker J., *Bhuju S., *Geffers R., Van Den Eede

N., McClure C.P., Troise F., Verhoye L., Baumert T., Farhoudi A., Cortese R., Ball J.K., Leroux-Roels G.,

*Pietschmann T., Nicosia A., Meuleman P. (2015) Targeting a host-cell entry factor barricades

antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice Gut 65: 2029 -

2034.

*Anggakusuma, Colpitts C.C., Schang L.M., Rachmawati H., *Frentzen A., *Pfaender S., *Behrendt P.,

*Brown R.J.P., *Bankwitz D., Steinmann J., *Ott M., Meuleman P., Rice C.M., Ploss A., *Pietschmann

T., *Steinmann E. (2014) Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into

human liver cells Gut 63: 1137 - 1149.

*Bankwitz D., *Vieyres G., *Hueging K., *Bitzegeio J., *Doepke M., *Chhatwal P., *Haid S., Catanese

M.T., Zeisel M.B., Nicosia A., Baumert T.F., Kaderali L., *Pietschmann T. (2014) Role of hypervariable

region 1 for the interplay of hepatitis C virus with entry factors and lipoproteins Journal of Virology

88: 12644 - 12655.

*Doerrbecker J., *Friesland M., *Riebesehl N., *Ginkel C., *Behrendt P., *Brown R.J., *Ciesek S.,

Wedemeyer H., Sarrazin C., Kaderali L., *Pietschmann T., *Steinmann E. (2014) Incorporation of

primary patient-derived glycoproteins into authentic infectious hepatitis C virus particles Hepatology

60: 508 - 520.

*Frentzen A., *Anggakusuma, Gurlevik E., *Hueging K., Knocke S., *Ginkel C., *Brown R.J., Heim M.,

Dill M.T., *Kröger A., *Kalinke U., Kaderali L., Kuehnel F., *Pietschmann T. (2014) Cell entry, efficient

RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells.


*Gerold G., *Pietschmann T. (2014) The HCV life cycle: In vitro tissue culture systems and therapeutic

targets Digestive Diseases 32: 525 - 537.

*Haid S., *Grethe C., Dill M.T., Heim M., Kaderali L., *Pietschmann T. (2014) Isolate-dependent use of

61

claudins for cell entry by hepatitis C virus. Hepatology 59: 24 - 34.

*Hueging K., *Doepke M., *Vieyres G., *Bankwitz D., *Frentzen A., *Doerrbecker J., *Gumz F., *Haid

S., Wolk B., Kaderali L., *Pietschmann T. (2014) Apolipoprotein E codetermines tissue tropism of

hepatitis C virus and is crucial for viral cell-to-cell transmission by contributing to a postenvelopment

step of assembly Journal of Virology 88: 1433 - 1446.

Irving W.L., Rupp D., McClure C.P., Than L.M., Titman A., Ball J.K., *Steinmann E., Bartenschlager R.,

*Pietschmann T., Brown R.J.P. (2014) Development of a high-throughput pyrosequencing assay for

monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus

protease coding-region Antiviral Research 110: 52 - 59.

Lange M., Fiedler M., *Bankwitz D., Osburn W., Viazov S., Brovko O., Zekri A.-R., Khudyakov Y., Nassal

M., Pumpens P., *Pietschmann T., Timm J., Roggendorf M., Walker A. (2014) Hepatitis C virus

hypervariable region 1 variants presented on hepatitis B virus capsid-like particles induce cross-

neutralizing antibodies PLoS ONE 9: e102235.

*Pfaender S., *Brown R.J.P., *Pietschmann T., *Steinmann E. (2014) Natural reservoirs for homologs

of hepatitis C virus Emerging Microbes and Infections 3: e21.

*Pietschmann T. (2014) In sero veritas: What serum markers teach us about HCV infection of primary

human hepatocytes Gut 63: 1375 - 1377.

*Vieyres G., Dubuisson J., *Pietschmann T. (2014) Incorporation of hepatitis C virus E1 and E2

glycoproteins: The keystones on a peculiar virion Viruses 6: 1149 - 1187.

Vercauteren K., Van Den Eede N., Mesalam A.A., Belouzard S., Catanese M.T., *Bankwitz D., Wong-

Staal F., Cortese R., Dubuisson J., Rice C.M., *Pietschmann T., Leroux-Roels G., Nicosia A., Meuleman

P. (2014) Successful anti-scavenger receptor class B type I (SR-BI) monoclonal antibody therapy in

humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents

Hepatology 60: 1508 - 1518.

*Behrendt P., *Doerrbecker J., *Riebesehl N., *Wilhelm C., *Ciesek S., Erichsen T.J., Steinmann J., Ott

M., Manns M.P., *Pietschmann T., *Steinmann E. (2013) Stability and transmission of hepatitis C

virus in different anesthetic agents American Journal of Infection Control 41: 942 - 943.

*Doerrbecker J., *Behrendt P., Mateu-Gelabert P., *Ciesek S., *Riebesehl N., *Wilhelm C., Steinmann

J., *Pietschmann T., *Steinmann E. (2013) Transmission of hepatitis C virus among people who inject

drugs: Viral stability and association with drug preparation equipment Journal of Infectious Diseases

207: 281 - 287.

*Doerrbecker J., Meuleman P., Kang J., *Riebesehl N., *Wilhelm C., *Friesland M., *Pfaender S.,

Steinmann J., *Pietschmann T., *Steinmann E. (2013) Thermostability of seven hepatitis C virus

genotypes in vitro and in vivo Journal of Viral Hepatitis 20: 478 - 485.

*Gentzsch J., *Brohm C., *Steinmann E., *Friesland M., *Menzel N., *Vieyres G., *Perin P.M.,

*Frentzen A., Kaderali L., *Pietschmann T. (2013) Hepatitis C Virus p7 is Critical for Capsid Assembly

and Envelopment PLoS Pathogens 9: e1003355.

62

*Gerold G., *Pietschmann T. (2013) Hepatitis C virus NS5B polymerase primes innate immune

signaling Hepatology 57: 1275 - 1277.

Hamming O.J., Terczynska-Dyla E., *Vieyres G., Dijkman R., Jorgensen S.E., Akhtar H., Siupka P.,

*Pietschmann T., Thiel V., Hartmann R. (2013) Interferon lambda 4 signals via the IFNʎ receptor to

regulate antiviral activity against HCV and coronaviruses EMBO Journal 32: 3055 - 3065.

*Nandakumar R., *Finsterbusch K., *Lipps C., *Neumann B., *Grashoff M., *Nair S., *Hochnadel I.,

*Lienenklaus S., *Wappler I., *Steinmann E., *Hauser H., *Pietschmann T., *Kroger A. (2013)

Hepatitis C virus replication in mouse cells is restricted by IFN-dependent and -independent

mechanisms Gastroenterology 145: 1414 - 1423.e1.

*Pfaender S., *Heyden J., *Friesland M., Ciesek S., Ejaz A., Steinmann J., Steinmann J., Malarski A.,

Stoiber H., Tsiavaliaris G., Bader W., Jahreis G., *Pietschmann T., *Steinmann E. (2013) Inactivation of

hepatitis C virus infectivity by human breast milk Journal of Infectious Diseases 208: 1943 - 1952.

Steinmann J., Buer J., *Pietschmann T., *Steinmann E. (2013) Anti-infective properties of

Epigallocatechin-3-gallate (EGCG), a component of green tea British Journal of Pharmacology 168:

1059 - 1073.

*Steinmann E., *Doerrbecker J., *Friesland M., *Riebesehl N., *Ginkel C., *Hillung J., *Gentzsch J.,

Lauber C, *Brown R., *Frentzen A., *Pietschmann T. (2013) Characterization of hepatitis C virus intra-

and intergenotypic chimeras reveals a role of the glycoproteins in virus envelopment Journal of

Virology 87: 13297 - 13306.

*Steinmann E., *Gravemann U., *Friesland M., *Doerrbecker J., *Muller T.H., *Pietschmann T.,

*Seltsam A. (2013) Two pathogen reduction technologies - Methylene blue plus light and shortwave

ultraviolet light - Effectively inactivate hepatitis C virus in blood products Transfusion 53: 1010 -

1018.

*Steinmann E., *Pietschmann T. (2013) Cell culture systems for hepatitis C virus Current Topics in

Microbiology and Immunology 369: 17 - 48.

*Vieyres G., *Brohm C., *Friesland M., *Gentzsch J., Wolk B., Roingeard P., *Steinmann E.,

*Pietschmann T. (2013) Subcellular localization and function of an epitope-tagged p7 viroporin in

hepatitis C virus-producing cells Journal of Virology 87: 1664 - 1678.

*Vieyres G., *Pietschmann T. (2013) Entry and replication of recombinant hepatitis C viruses in cell

culture Methods 59: 233 - 248.

Westhaus S., *Bankwitz D., Ernst S., Rohrmann K., *Wappler I., Agne C., Luchtefeld M., Schieffer B.,

Sarrazin C., Manns M.P., *Pietschmann T., *Ciesek S., Von Hahn T. (2013) Characterization of the

inhibition of hepatitis C virus entry by In vitro-generated and patient-derived oxidized low-density

lipoprotein Hepatology 57: 1716 - 1724.

Zahid M.N., Turek M., Xiao F., Dao Thi V.L., Guerin M., Fofana I., Bachellier P., Thompson J., Delang L.,

Neyts J., *Bankwitz D., *Pietschmann T., Dreux M., Cosset F.-L., Grunert F., Baumert T.F., Zeisel M.B.

63

(2013) The postbinding activity of scavenger receptor class B type I mediates initiation of hepatitis C

virus infection and viral dissemination Hepatology 57: 492 - 504.

64

Rohde, Manfred

*Abraham W.-R., *de Carvalho M.P., *da Costa Neves T.S.P., *Memoria M.T., *Tartuci I.T.,

Vancanneyt M., Smit J., *Rohde M. (2017) Proposal of Henriciella barbarensis sp. nov. and Henriciella

algicola sp. nov., stalked species of the genus and emendation of the genus Henriciella International

Journal of Systematic and Evolutionary Microbiology 67: 2804 - 2810.

*Bergmann S., Eichhorn I., Kohler T.P., Hammerschmidt S., *Goldmann O., *Rohde M., *Fulde M.

(2017) SCM, the M protein of Streptococcus canis binds immunoglobulin G Frontiers in Cellular and

Infection Microbiology 7: 80.

Boedeker C., Schüler M., Reintjes G., Jeske O., Van Teeseling M.C.F., Jogler M., Rast P., Borchert D.,

Devos D.P., *Kucklick M., Schaffer M., Kolter R., Van Niftrik L., *Engelmann S., Amann R., *Rohde M.,

Engelhardt H., Jogler C. (2017) Determining the bacterial cell biology of Planctomycetes Nature

Communications 8: 14853.

Camacho M., Redondo-Gomez S., Rodríguez-Llorente I., *Rohde M., Spröer C., Schumann P., Klenk

H.-P., Montero-Calasanz M.C. (2017) Kocuria salina sp. nov., an actinobacterium isolated from the

rhizosphere of the halophyte Arthrocnemum macrostachyum and emended description of Kocuria

turfanensis International Journal of Systematic and Evolutionary Microbiology 67: 5006 - 5012.

Couvigny B., Lapaque N., Rigottier-Gois L., Guillot A., Chat S., Meylheuc T., Kulakauskas S., *Rohde

M., Mistou M.-Y., Renault P., Doré J., Briandet R., Serror P., Guédon E. (2017) Three glycosylated

serine-rich repeat proteins play a pivotal role in adhesion and colonization of the pioneer commensal

bacterium, Streptococcus salivarius Environmental Microbiology 19: 3579 - 3594.

Dreiseikelmann B., Bunk B., Spröer C., *Rohde M., *Nimtz M., Wittmann J. (2017) Characterization

and genome comparisons of three Achromobacter phages of the family Siphoviridae Archives of

Virology 162: 2191 - 2201.

Elamin A.A., Steinicke S., Oehlmann W., Braun Y., Wanas H., Shuralev E.A., Huck C., Maringer M.,

*Rohde M., Singh M. (2017) Novel drug targets in cell wall biosynthesis exploited by gene disruption

in Pseudomonas aeruginosa PLoS ONE 12: e0186801.

Gottschick C, Deng ZL, Vital M, Masur C, Abels C, Pieper DH, Rohde M, Mendling W, Wagner-Döbler I.

(2017) Treatment of biofilms in bacterial vaginosis by an amphoteric tenside pessary-clinical study

and microbiota analysis Microbiome 5: 119.

Hahn M.W., Schmidt J., Koll U., *Rohde M., Verbarg S., Pitt A., Nakai R., Naganuma T., Lang E. (2017)

Silvanigrella aquatica gen. nov., sp. nov., isolated from a freshwater lake, description of

silvanigrellaceae fam. nov. and silvanigrellales ord. nov., reclassification of the order

bdellovibrionales in the class oligoflexia, reclassification of the famil International Journal of

Systematic and Evolutionary Microbiology 67: 2555 - 2568.

Heß N., Waldow F., Kohler T.P., *Rohde M., Kreikemeyer B., Gómez-Mejia A., Hain T., Schwudke D.,

Vollmer W., Hammerschmidt S., Gisch N. (2017) Lipoteichoic acid deficiency permits normal growth

but impairs virulence of Streptococcus pneumonia Nature Communications 8: 2093.

Hezbri K., Nouioui I., *Rohde M., Schumann P., Gtari M., Klenk H.-P., Montero-Calasanz M.D.C.,

65

Ghodhbane-Gtari F. (2017) Blastococcus colisei sp. nov, isolated from an archaeological amphitheatre

Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology 110: 339 -

346.

Kanwal S, Jensch I, Palm GJ, *Brönstrup M, *Rohde M, Kohler TP, Somplatzki D, *Tegge W, Jenkinson

HF, Hammerschmidt S. (2017) Mapping the recognition domains of pneumococcal fibronectin-

binding proteins PavA and PavB demonstrates a common pattern of molecular interactions with

fibronectin type III repeats Molecular Microbiology 105: 839 - 859.

*Landwehr W, Kämpfer P, Glaeser SP, Rückert C, Kalinowski J, Blom J, Goesmann A, Mack M,

Schumann P, Atasayar E, Hahnke RL, *Rohde M, Martin K, *Stadler M, *Wink J. (2017) Taxonomic

analyses of members of the Streptomyces cinnabarinus cluster, description of Streptomyces

cinnabarigriseus sp. nov. and Streptomyces davaonensis sp. nov International Journal of Systematic

and Evolutionary Microbiology Int J Syst Evol Microbiol. 2017 Dec 11. doi: 10.1099/ijsem.0.002519.

Mohammadipanah F., Montero-Calasanz M.C., Schumann P., Spröer C., *Rohde M., Klenk H.-P.

(2017) Promicromonospora kermanensis sp. nov., an actinobacterium isolated from soil International


Montero-Calasanz M.C., Meier-Kolthoff J.P., Zhang D.-F., Yaramis A., *Rohde M., Woyke T., Kyrpides

N.C., Schumann P., Li W.-J., Göker M. (2017) Genome-scale data call for a taxonomic rearrangement

of Geodermatophilaceae Frontiers in Microbiology 8: 2501.

Nouioui I, Ghodhbane-Gtari F, Rohde M, Klenk HP, Gtari M. (2017) Frankia coriariae sp. nov., an

infective and effective microsymbiont isolated from Coriaria japonica International Journal of


Nouioui I., Del Carmen Montero-Calasanz M., Ghodhbane-Gtari F., *Rohde M., Tisa L.S., Klenk H.-P.,

Gtari M. (2017) Frankia discariae sp. nov.: an infective and effective microsymbiont isolated from the

root nodule of Discaria trinervis Archives of Microbiology 199: 641 - 647.

Nouioui I., Ghodhbane-Gtari F., Del Carmen Montero-Calasanz M., *Rohde M., Tisa L.S., Gtari M.,

Klenk H.-P. (2017) Frankia inefficax sp. nov., an actinobacterial endophyte inducing ineffective, non

nitrogen-fixing, root nodules on its actinorhizal host plants Antonie van Leeuwenhoek, International

Journal of General and Molecular Microbiology doi: 10.1007/s10482-016-0801-7.

Nouioui I., Göker M., Carro L., Montero-Calasanz M.C., *Rohde M., Woyke T., Kyrpides N.C., Klenk H.-

P. (2017) High quality draft genome of Nakamurella lactea type strain, a rock actinobacterium, and

emended description of Nakamurella lactea Standards in Genomic Sciences 12: 4.

Panschin I., Becher M., Verbarg S., Spröer C., *Rohde M., Schüler M., Amann R.I., Harder J., Tindall

B.J., Hahnke R.L. (2017) Description of Gramella forsetii sp. nov., a marine Flavobacteriaceae isolated

from North Sea water, and emended description of Gramella gaetbulicola Cho et al. 2011

International Journal of Systematic and Evolutionary Microbiology 67: 697 - 703.

*Pasztoi M, Bonifacius A, *Pezoldt J, Kulkarni D, Niemz J, Yang J, Teich R, Hajek J, *Pisano F, *Rohde

M, *Dersch P, *Huehn J. (2017) Yersinia pseudotuberculosis supports Th17 differentiation and limits

de novo regulatory T cell induction by directly interfering with T cell receptor signaling Cellular and

66

Molecular Life Sciences 74: 2839 - 2850.

*Pasztoi M., *Pezoldt J., *Beckstette M., *Lipps C., *Wirth D., *Rohde M., Paloczi K., Buzas E.I.,

*Huehn J. (2017) Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to

peripheral de novo induction of Foxp3+ regulatory T cells European Journal of Immunology 47: 2142

- 2152.

*Rahim M.I., *Babbar A., *Lienenklaus S., *Pils M.C., *Rohde M. (2017) Degradable magnesium

implant-associated infections by bacterial biofilms induce robust localized and systemic inflammatory

reactions in a mouse model Biomedical Materials 12: 55006.

*Rahim MI, Weizbauer A, Evertz F, Hoffmann A, *Rohde M, Glasmacher B, Windhagen H, *Gross G,

Seitz JM, *Mueller PP. (2017) Differential magnesium implant corrosion coat formation and

contribution to bone bonding Journal of Biomedical Materials Research - Part A 105: 697 - 709.

Rast P., Glöckner I., Boedeker C., Jeske O., Wiegand S., Reinhardt R., Schumann P., *Rohde M., Spring

S., Glöckner F.O., Jogler C., Jogler M. (2017) Three novel species with peptidoglycan cell walls form

the new genus Lacunisphaera gen. nov. in the family opitutaceae of the verrucomicrobial subdivision

4 Frontiers in Microbiology 8: 202.

*Rox K., *Rohde M., *Chhatwal G.S., *Müller R. (2017) Disorazoles Block Group A Streptococcal

Invasion into Epithelial Cells Via Interference with the Host Factor Ezrin Cell Chemical Biology 24: 159

- 170.

Skive B., *Rohde M., *Molinari G., Braunstein T.H., Bojesen A.M. (2017) Streptococcus equi subsp.

zooepidemicus invades and survives in epithelial cells Frontiers in Cellular and Infection


*Szafranski SP, Deng ZL, *Tomasch J, *Jarek M, *Bhuju S, *Rohde M, *Sztajer H, *Wagner-Döbler I.

(2017) Quorum sensing of Streptococcus mutans is activated by Aggregatibacter

actinomycetemcomitans and by the periodontal microbiome BMC Genomics 18: 238.

Tegtmeyer N., Wessler S., Necchi V., *Rohde M., Harrer A., Rau T.T., Asche C.I., Boehm M., Loessner

H., Figueiredo C., Naumann M., Palmisano R., Solcia E., Ricci V., Backert S. (2017) Helicobacter pylori

Employs a Unique Basolateral Type IV Secretion Mechanism for CagA Delivery Cell Host and Microbe

22: 552 - 560.e5.

Tong J, Fu Y, Wu NH, *Rohde M, Meng F, Valentin-Weigand P, Herrler G. (2017) Sialic acid-dependent

interaction of group B streptococci with influenza virus-infected cells reveals a novel adherence and

invasion mechanism Cellular Microbiology Cell Microbiol. 2017 Dec 22. doi: 10.1111/cmi.12818.

Akhwale J.K., Göker M., *Rohde M., Schumann P., Boga H.I., Klenk H.-P. (2016) Nocardiopsis

mwathae sp. nov., isolated from the haloalkaline Lake Elmenteita in the African Rift Valley Antonie

van Leeuwenhoek, International Journal of General and Molecular Microbiology 109: 421 - 430.

Borrero-de Acuña J.M., *Rohde M., *Wissing J., *Jänsch L., Schobert M., *Molinari G., *Timmis K.N.,

Jahn M., Jahn D. (2016) Protein network of the Pseudomonas aeruginosa denitrification apparatus

Journal of Bacteriology 198: 1401 - 1413.

67

Brouwer S., Barnett T.C., Rivera-Hernandez T., *Rohde M., Walker M.J. (2016) Streptococcus

pyogenes adhesion and colonization FEBS Letters 590: 3739 - 3757.

Camacho M., Redondo-Gómez S., Rodrìguez-Llorente I., *Rohde M., Spröer C., Schumann P., Klenk

H.-P., Montero-Calasanz M.C. (2016) Labrenzia salina sp. Nov., isolated from the rhizosphere of the

halophyte Arthrocnemum macrostachyum International Journal of Systematic and Evolutionary


Cypionka H., Völcker E., *Rohde M. (2016) Erzeugung virtueller 3D-Bilder mit jedem Lichtmikroskop

oder REM BioSpektrum 22: 143 - 145.

Elnakady Y.A.*, Chatterjee I., Bischoff M., *Rohde M., Josten M., Sahl H.-G., Herrmann M., *Müller R.

(2016) Investigations to the antibacterial mechanism of action of Kendomycin PLoS ONE 11:

e0146165.

Felgner S.*, *Frahm M., *Kocijancic D., *Rohde M., *Eckweiler D., *Bielecka A., Bueno E., Cava F.,



Foesel B.U., Geppert A., *Rohde M., Overmann J. (2016) Parviterribacter kavangonensis gen. Nov.,

sp. nov. and Parviterribacter multiflagellatus sp. nov., Novel members of Parviterribacteraceae fam.

nov. within the order Solirubrobacterales, and emended descriptions of the classes Thermoleophilia

and Rubrobact International Journal of Systematic and Evolutionary Microbiology 66: 652 - 665.

Foesel B.U., Mayer S., Luckner M., Wanner G., *Rohde M., Overmann J. (2016) Occallatibacter

riparius gen. Nov., sp. nov. and Occallatibacter savannae sp. nov., acidobacteria isolated from

namibian soils, and emended description of the family acidobacteriaceae International Journal of


Goldmann O.*, Tuchscherr L., *Rohde M., *Medina E. (2016) Alpha-Hemolysin enhances

Staphylococcus aureus internalization and survival within mast cells by modulating the expression of

beta1 integrin Cellular Microbiology 18: 807 - 819.

Hezbri K., Ghodhbane-Gtari F., Montero-Calasanz M.C., Nouioui I., *Rohde M., Spröer C., Schumann

P., Klenk H.-P., Gtari M. (2016) Geodermatophilus pulveris sp. nov., a gamma-radiation-resistant

actinobacterium isolated from Sahara desert International Journal of Systematic and Evolutionary


Hezbri K., Louati M., Nouioui I., Gtari M., *Rohde M., Spröer C., Schumann P., Klenk H.-P.,

Ghodhbane-Gtari F., Del Carmen Montero-Calasanz M. (2016) Blastococcus capsensis sp. Nov.,

isolated from an archaeological roman pool and emended description of the genus Blastococcus, B.

aggregatus, B. saxobsidens, B. jejuensis and B. endophyticus International Journal of Systematic and

Evolutionary Microbiology 66: 4864 - 4872.

Kappler U., Davenport K., Beatson S., Lapidus A., Pan C., Han C., Montero-Calasanz M.C., Land M.,

Hauser L., *Rohde M., Göker M., Ivanova N., Woyke T., Klenk H.-P., Kyrpides N.C. (2016) Complete

genome sequence of the haloalkaliphilic, obligately chemolithoautotrophic thiosulfate and sulfide-

68

oxidizing ϒ-proteobacterium Thioalkalimicrobium cyclicum type strain ALM 1 (DSM 14477T)

Standards in Genomic Sciences 11: 38.

*Kocijancic D., *Felgner S., *Frahm M., *Komoll R.-M., *Iljazovic A., *Pawar V., *Rohde M., Heise U.,

Zimmermann K., Gunzer F., *Hammer J., *Crull K., *Leschner S., *Weiss S. (2016) Therapy of solid

tumors using probiotic Symbioflor-2-restraints and potential Oncotarget 7: 22605 - 22622.

Kohn T., Heuer A., Jogler M., Vollmers J., Boedeker C., Bunk B., Rast P., Borchert D., Glöckner I.,

Freese H.M., Klenk H.-P., Overmann J., Kaster A.-K., *Rohde M., Wiegand S., Jogler C. (2016) Fuerstia

marisgermanicae gen. nov., sp. nov., an unusual member of the phylum planctomycetes from the

german wadden sea Frontiers in Microbiology 7: 2079.

Kuipers K., Gallay C., Martínek V., *Rohde M., Martínková M., van der Beek S.L., Jong W.S.P.,

Venselaar H., Zomer A., Bootsma H., Veening J.-W., de Jonge M.I. (2016) Highly conserved nucleotide

phosphatase essential for membrane lipid homeostasis in Streptococcus pneumoniae Molecular


Kumaraswamy M., Lin L., Olson J., Sun C.-F., Nonejuie P., Corriden R., Döhrmann S., Ali S.R., Amaro

D., *Rohde M., Pogliano J., Sakoulas G., Nizet V. (2016) Standard susceptibility testing overlooks

potent azithromycin activity and cationic peptide synergy against MDR Stenotrophomonas

maltophilia Journal of Antimicrobial Chemotherapy 71: 1264 - 1269.

Lerner T.R., Carvalho-Wodarz C.D.S., Repnik U., Russell M.R.G., Borel S., DIedrich C.R., *Rohde M.,

Wainwright H., Collinson L.M., Wilkinson R.J., Griffiths G., Gutierrez M.G. (2016) Lymphatic

endothelial cells are a replicative niche for Mycobacterium tuberculosis Journal of Clinical

Investigation 126: 1093 - 1108.

*Neumann Y., *Bruns S.A., *Rohde M., Prajsnar T.K., Foster S.J., *Schmitz I. (2016) Intracellular

Staphylococcus aureus eludes selective autophagy by activating a host cell kinase Autophagy 12:

2069 - 2084.

Nouioui I., Ghodhbane-Gtari F., Montero-Calasanz M.C., Göker M., Meier-Kolthoff J.P., Schumann P.,

*Rohde M., Goodfellow M., Fernandez M.P., Normand P., Tisa L.S., Klenk H.-P., Gtari M. (2016)

Proposal of a type strain for Frankia alni (Woronin 1866) Von Tubeuf 1895, emended description of

Frankia alni, and recognition of Frankia casuarinae sp. nov. and Frankia elaeagni sp. nov.


Panschin I., Huang S., Meier-Kolthoff J.P., Tindall B.J., *Rohde M., Verbarg S., Lapidus A., Han J., Trong

S., Haynes M., Reddy T.B.K., Huntemann M., Pati A., Ivanova N.N., Mavromatis K., Markowitz V.,

Woyke T., Göker M., Klenk H.-P., Kyrpides N.C., Hahnke R.L. (2016) Comparing polysaccharide

decomposition between the type strains Gramella echinicola KMM 6050T (DSM 19838T) and

Gramella portivictoriae UST040801-001T (DSM 23547T), and emended description of Gramella

echinicola Nedashkovskaya et al. 2005 emend. Shahina et al. 2014 and Gramella portivictoriae Lau et

al. 2005.Standards in Genomic Sciences 11: 37.

*Rahim M.I., *Rohde M., *Rais B., Seitz J.-M., *Mueller P.P. (2016) Susceptibility of metallic

magnesium implants to bacterial biofilm infections Journal of Biomedical Materials Research - Part

A 104: 1489 - 1499.

69

Spring S., Bunk B., Spröer C., Schumann P., *Rohde M., Tindall B.J., Klenk H.-P. (2016)

Characterization of the first cultured representative of Verrucomicrobia subdivision 5 indicates the

proposal of a novel phylum ISME Journal 10: 2801 - 2816.

Tashkandy N., Sabban S., Fakieh M., Meier-Kolthoff J.P., Huang S., Tindall B.J., *Rohde M., Baeshen

M.N., Baeshen N.A., Lapidus A., Copeland A., Pillay M., Reddy T.B.K., Huntemann M., Pati A., Ivanova

N., Markowitz V., Woyke T., Göker M., Klenk H.-P., Kyrpides N.C., Hahnke R.L. (2016) High-quality

draft genome sequence of Flavobacterium suncheonense GH29-5T (DSM 17707T) isolated from

greenhouse soil in South Korea, and emended description of Flavobacterium suncheonense GH29-5T

Standards in Genomic Sciences 11: 42.

Akhwale J.K., Göker M., *Rohde M., Schumann P., Klenk H.-P., Boga H.I. (2015) Belliella kenyensis sp.

Nov., isolated from an alkaline lake International Journal of Systematic and Evolutionary


Akhwale J.K., Göker M., *Rohde M., Sproer C., Schumann P., Klenk H.-P., Boga H.I.G (2015)

Streptomyces alkaliphilus sp. nov., isolated from sediments of Lake Elmenteita in the Kenyan Rift

Valley Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology

107: 1249 - 1259.

*Badar M., *Rahim M.I., Kieke M., Ebel T., *Rohde M., *Hauser H., Behrens P., *Mueller P.P. (2015)

Controlled drug release from antibiotic-loaded layered double hydroxide coatings on porous titanium

implants in a mouse model Journal of Biomedical Materials Research - Part A 103: 2141 - 2149.

Beims H., Wittmann J., Bunk B., Spröer C., Rohde C., Günther G., *Rohde M., von der Ohe W.,

*Steinert M. (2015) Paenibacillus larvae-directed bacteriophage HB10c2 and its application in

American foulbrood-affected honey bee larvae Applied and Environmental Microbiology 81: 5411 -

5419.

*Borrero-de Acuna J.M., *Molinari G., *Rohde M., Dammeyer T., *Wissing J., *Jänsch L., *Arias S.,

Jahn M., Schobert M., *Timmis K.N., Jahn D. (2015) A periplasmic complex of the nitrite reductase

NirS, the chaperone DnaK, and the flagellum protein FliC is essential for flagellum assembly and

motility in Pseudomonas aeruginosa Journal of Bacteriology 197: 3066 - 3075.

Choi D.H., Ahn C., Jang G.I., Lapidus A., Han J., Reddy T.B., Huntemann M., Pati A., Ivanova N.,

Markowitz V., *Rohde M., Tindall B., Göker M., Woyke T., Klenk H.P., Kyrpides N..C, Cho B.C. (2015)

High-quality draft genome sequence of Gracilimonas tropica CL-CB462T (DSM 19535T), isolated from

a Synechococcus culture Standards in Genomic Sciences 10: 98.

*Deditius J.A., *Felgner S., *Spöring I., *Kühne C., *Frahm M., *Rohde M., *Weiß S., *Erhardt M.

(2015) Characterization of novel factors involved in swimming and swarming motility in Salmonella

enterica serovar typhimurium PLoS ONE 10: e0135351.

Didiasova M., Zakrzewicz D., Magdolen V., Nagaraj C., Balint Z., *Rohde M., Preissner K.T., Wygrecka

M. (2015) STIM1/ORAI1-mediated Ca2+ influx regulates enolase-1 exteriorization Journal of

Biological Chemistry 290: 11983 - 11999.

70

Eisenberg T., Hudemann C., Hossain H.M., Hewer A., Tello K., Bandorski D., *Rohde M., Valentin-

Weigand P., Baums C.G. (2015) Characterization of five zoonotic Streptococcus suis strains from

Germany, including one isolate from a recent fatal case of streptococcal toxic shock-like syndrome in

a hunter Journal of Clinical Microbiology 53: 3912 - 3915.

*Frahm M., *Felgner S., *Kocijancic D., *Rohde M., Hensel M., Curtiss I.R., *Erhardt M., *Weiss S.

(2015) Efficiency of conditionally attenuated Salmonella enterica serovar typhimurium in bacterium-

mediated tumor therapy mBio 6: 1 - 11.

Frank O., Michael V., Pauker O., Boedeker C., Jogler C., *Rohde M., Petersen J. (2015) Plasmid curing

and the loss of grip - The 65-kb replicon of Phaeobacter inhibens DSM 17395 is required for biofilm

formation, motility and the colonization of marine algae Systematic and Applied Microbiology 38:

120 - 127.

Hahnke R.L., Stackebrandt E., Meier-Kolthoff J.P., Tindall B.J., Huang S., *Rohde M., Lapidus A., Han J.,

Trong S., Haynes M., Reddy T.B.K., Huntemann M., Pati A., Ivanova N.N., Mavromatis K., Markowitz

V., Woyke T., Göker M., Kyrpides N.C., Klenk H.-P. (2015) High quality draft genome sequence of

Flavobacterium rivuli type strain WB 3.3-2T (DSM 21788T), a valuable source of polysaccharide

decomposing enzymes Standards in Genomic Sciences 10.

Hezbri K., Ghodhbane-Gtari F., del Carmen Montero-Calasanz M., Sghaier H., *Rohde M., Schumann

P., Klenk H.-P., Gtari M. (2015) Description of Geodermatophilus bullaregiensis sp. Nov Antonie van

Leeuwenhoek, International Journal of General and Molecular Microbiology 108: 415 - 425.

Hezbri K., Ghodhbane-Gtari F., Del Carmen Montero-Calasanz M., Sghaier H., *Rohde M., Sproer C.,

Schumann P., Klenk H.-P., Gtari M. (2015) Geodermatophilus aquaeductus sp. nov., isolated from the

ruins of Hadrian’s aqueduct Antonie van Leeuwenhoek, International Journal of General and

Molecular Microbiology 108: 41 - 50.

Hezbri K., Ghodhbane-Gtari F., Montero-Calasanz M.C., Sghaier H., *Rohde M., Schumann P., Klenk

H.-P., Gtari M. (2015) Geodermatophilus sabuli sp. Nov., a-radiation-resistant actinobacterium

isolated from desert limestone International Journal of Systematic and Evolutionary Microbiology

65: 3365 - 3372.

Jeske O., Schüler M., Schumann P., Schneider A., Boedeker C., Jogler M., Bollschweiler D., *Rohde M.,

Mayer C., Engelhardt H., Spring S., Jogler C. (2015) Planctomycetes do possess a peptidoglycan cell

wall Nature Communications 6: 7116.

Laviad S., Lapidus A., Han J., Haynes M., Reddy T.B.K., Huntemann M., Pati A., Ivanova N.N.,

Mavromatis K., Lang E., *Rohde M., Markowitz V., Woyke T., Klenk H.-P., Kyrpides N.C., Halpern M.

(2015) High quality draft genome sequence of Brachymonas chironomi AIMA4T (DSM 19884T)

isolated from a chironomus sp. egg mass Standards in Genomic Sciences 10.

Lin L., Nonejuie P., Munguia J., Hollands A., Olson J., Dam Q., Kumaraswamy M., Rivera H., Corriden

R., *Rohde M., Hensler M.E., Burkart M.D., Pogliano J., Sakoulas G., Nizet V. (2015) Azithromycin

Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against

Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens EBioMedicine 2: 690 - 698.

Montero-Calasanz M.D.C., Hezbri K., Göker M., Sghaier H., *Rohde M., Sproer C., Schumann P., Klenk

71

H.-P. (2015) Description of gamma radiation-resistant Geodermatophilus dictyosporus sp. nov. to

accommodate the not validly named Geodermatophilus obscurus subsp. dictyosporus (Luedemann,

1968) Extremophiles 19: 77 - 85.

*Pawar V., *Komor U., *Kasnitz N., *Bielecki P., *Pils M.C., Gocht B., Moter A., *Rohde M., *Weiss S.,

*Haussler S. (2015) In vivo efficacy of antimicrobials against biofilm-producing Pseudomonas

aeruginosa Antimicrobial Agents and Chemotherapy 59: 4974 - 4981.

*Sood S., *Awal R.P., *Wink J., *Mohr K.I., *Rohde M., *Stadler M., Kampfer P., Glaeser S.P.,

Schumann P., *Garcia R., *Muller R. (2015) Aggregicoccus edonensis gen. nov., sp. nov., an unusually

aggregating myxobacterium isolated from a soil sample International Journal of Systematic and


Tsatsaronis J.A., Ly D., Pupovac A., *Goldmann O., *Rohde M., Taylor J.M., Walker M.J., *Medina E.,

Sanderson-Smith M.L. (2015) Group A Streptococcus Modulates Host Inflammation by Manipulating

Polymorphonuclear Leukocyte Cell Death Responses Journal of Innate Immunity 7: 612 - 622.

Walden M., Edwards J.M., Dziewulska A.M., Bergmann R., Saalbach G., Kan S.Y., Miller O.K.,

Weckener M., Jackson R.J., Shirran S.L., Botting C.H., Florence G.J., *Rohde M., Banfield M.J.,

Schwarz-Linek U. (2015) An internal thioester in a pathogen surface protein mediates covalent host

binding eLife 4: 1 - 24.

Abdullah M.R., Gutierrez-Fernandez J., Pribyl T., Gisch N., Saleh M., *Rohde M., Petruschka L.,

Burchhardt G., Schwudke D., Hermoso J.A., Hammerschmidt S. (2014) Structure of the pneumococcal

l,d-carboxypeptidase DacB and pathophysiological effects of disabled cell wall hydrolases DacA and

DacB Molecular Microbiology 93: 1183 - 1206.

*Abraham W.-R., *Rohde M. (2014) The family Hyphomonadaceae In: The Procaryotes-

Alphabacteria and Betaproteobacteria, doi: 10.1007/978-3-642-30197-1_260, Springer Berlin

Heidelberg pp 283 - 299.

*Abraham W.-R., *Rohde M., Bennasar A. (2014) The family Caulobacteraceae. In: The Procaryotes-

Alphabacteria and Betaproteobacteria, Springer Berlin Heidelberg pp 179 - 205.

Frank O., Pradella S., *Rohde M., Scheuner C., Klenk H.P., Göker M., Petersen J. (2014) Complete

genome sequence of the Phaeobacter gallaeciensis type strain CIP 105210T (= DSM 26640T =

BS107T) Standards in Genomic Sciences 9: 914 - 932.

Huber K.J., Wust P.K., *Rohde M., Overmann J., Foesel B.U. (2014) Aridibacter famidurans gen. nov.,

sp. nov. and Aridibacter kavangonensis sp. nov., two novel members of subdivision 4 of the

Acidobacteria isolated from semiarid savannah soil International Journal of Systematic and


Kuever J., Visser M., Loeffler C., Boll M., Worm P., Sousa D.Z., Plugge C.M., Schaap P.J., Muyzer G.,

Pereira I.A.C., Parshina S.N., Goodwin L.A., Kyrpides N.C., Detter J., Woyke T., Chain P., Davenport

K.W., *Rohde M., Spring S., Klenk H.-P., Stams A.J.M (2014) Genome analysis of Desulfotomaculum

gibsoniae strain GrollT a highly versatile Gram-positive sulfate-reducing bacterium Standards in

Genomic Sciences 9: 821 - 839.

72

Laass S., Kleist S., Bill N., Druppel K., Kossmehl S., Wohlbrand L., Rabus R., Klein J., *Rohde M.,

*Bartsch A., *Wittmann C., Schmidt-Hohagen K., Tielen P., Jahn D., Schomburg D. (2014) Gene

regulatory and metabolic adaptation processes of Dinoroseobacter shibae DFL12T during oxygen

depletion Journal of Biological Chemistry 289: 13219 - 13231.

Meklat A., Bouras N., Riba A., Zitouni A., Mathieu F., *Rohde M., Schumann P., Sproer C., Klenk H.-P.,

Sabaou N. (2014) Streptomonospora algeriensis sp. nov., a halophilic actinomycete isolated from soil

in Algeria Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology

106: 287 - 292.

Mohammadipanah F., Hamedi J., Spröer C., *Rohde M., Montero-Calasanz Mdel C., Klenk H.P. (2014)

Streptomyces zagrosensis sp. nov., isolated from soil International journal of systematic and

evolutionary microbiology 64: 3434 - 3440.

Montero-Calasanz M.d.C., Göker M., *Rohde M., Sproer C., Schumann P., Busse H.-J., Schmid M.,

Klenk H.-P., Tindall B.J., Camacho M. (2014) Chryseobacterium oleae sp. nov., an efficient plant

growth promoting bacterium in the rooting induction of olive tree (Olea europaea L.) cuttings and

emended descriptions of the genus Chryseobacterium, C. daecheongense, C. gambrini, C. gleum, C.

joostei, Systematic and Applied Microbiology 37: 342 - 350.

Montero-Calasanz M.D.C., Göker M., *Rohde M., Sproer C., Schumann P., Mayilraj S., Goodfellow M.,

Klenk H.-P. (2014) Description of Geodermatophilus amargosae sp. nov., to accommodate the not

validly named Geodermatophilus obscurus subsp. amargosae (Luedemann, 1968) Current


Montero-Calasanz M.D.C., Hofner B., Göker M., *Rohde M., Sproer C., Hezbri K., Gtari M., Schumann

P., Klenk H.-P. (2014) Geodermatophilus poikilotrophi sp. nov.: a multitolerant actinomycete isolated

from dolomitic marble BioMed research international 2014: 914767.

*Ochel A., *Rohde M., *Chhatwal G.S., *Talay S.R. (2014) The M1 Protein of Streptococcus pyogenes

triggers an innate uptake mechanism into polarized human endothelial cells Journal of Innate

Immunity 6: 585 - 596.

*Pawar V., *Crull K., *Komor U., *Kasnitz N., *Frahm M., *Kocijancic D., *Westphal K., *Leschner S.,

*Wolf K., *Loessner H., *Rohde M., *Häussler S., *Weiss S. (2014) Murine solid tumours as a novel

model to study bacterial biofilm formation in vivo Journal of Internal Medicine 276: 130 - 139.

*Poblete-Castro I., *Binger D., *Oehlert R., *Rohde M. (2014) Comparison of mcl-poly(3-

hydroxyalkanoates) synthesis by different Pseudomonas putida strains from crude glycerol: Citrate

accumulates at high titer under PHA-producing conditions BMC Biotechnology 14: 962.

*Sagar V., *Bergmann R., *Nerlich A., McMillan D.J., *Nitsche-Schmitz D.P., *Fulde M., *Talay S.,

*Geffers R., Hoe N., Kumar R., *Rohde M., Chakraborti A., *Chhatwal G.S. (2014) Differences in

virulence repertoire and cell invasive potential of Group A Streptococcus emm1-2 in comparison to

emm1 genotype International Journal of Medical Microbiology 304: 685 - 695.

Saker R., Bouras N., Zitouni A., Ghoul M., *Rohde M., Schumann P., Sproer C., Sabaou N., Klenk H.-P.

73

(2014) Mzabimyces algeriensis gen. nov., sp. nov., a halophilic filamentous actinobacterium isolated

from a Saharan soil, and proposal of Mzabimycetaceae fam. nov Antonie van Leeuwenhoek,

International Journal of General and Molecular Microbiology 106: 1021 - 1030.

*Scheb-Wetzel M., *Rohde M., Bravo A., *Goldmann O. (2014) New insights into the antimicrobial

effect of mast cells against Enterococcus faecalis Infection and Immunity 82: 4496 – 4507.

*Suwandi A., *Bargen I., *Roy B., *Pils M.C., *Krey M., *Zur Lage S., Basler T., *Rohde M., Falk C.S.,

Hornef M.W., Goethe R., *Weiss S. (2014) Experimental colitis is exacerbated by concomitant

infection with Mycobacterium avium ssp. paratuberculosis Inflammatory Bowel Diseases 20: 1962 -

1971.

*Szafranska A.K., *Oxley A.P.A., *Chaves-*Moreno D., *Horst S.A., Rosslenbroich S., Peters G.,

*Goldmann O., *Rohde M., Sinha B., *Pieper D.H., Loffler B., *Jauregui R., *Wos-Oxley M.L., *Medina

E. (2014) High-resolution transcriptomic analysis of the adaptive response of Staphylococcus aureus

during acute and chronic phases of osteomyelitis mBio 5: e01775-14 - .

*Sztajer H., *Szafranski S.P., *Tomasch J., *Reck M., *Nimtz M., *Rohde M., *Wagner-Döbler I. (2014)

Cross-feeding and interkingdom communication in dual-species biofilms of Streptococcus mutans and

Candida albicans ISME Journal 8: 2256 - 2271.

Wittmann J., Dreiseikelmann B., *Rohde M., Meier-Kolthoff J.P., Bunk B., Rohde C. (2014) First

genome sequences of Achromobacter phages reveal new members of the N4 family Virology Journal

11: 14.

Wittmann J., Dreiseikelmann B., Rohde C., *Rohde M., Sikorski J. (2014) Isolation and

characterization of numerous novel phages targeting diverse strains of the ubiquitous and

opportunistic pathogen Achromobacter xylosoxidans PLoS ONE 9: e86935.

Zhou Y., Li R., Gao X.Y., Lapidus A., Han J., Haynes M., Lobos E,. Huntemann M., Pati A., Ivanova N.N.,

*Rohde M., Mavromatis K., Tindall B.J., Markowitz .V, Woyke T., Klenk H.P., Kyrpides N.C., Li W.J.

(2014) High quality draft genome sequence of the slightly halophilic bacterium Halomonas

zhanjiangensis type strain JSM 078169T (DSM 21076T) from a sea urchin in southern China

Standards in Genomic Sciences 9: 1020 - 1030.

*Abraham W.-R., *Estrela A.B., *Rohde M., Smit J., Vancanneyt M. (2013) Prosthecate

sphingomonads: Proposal of Sphingomonas canadensis sp. nov International Journal of Systematic

and Evolutionary Microbiology 63: 3214 - 3219.

Anderson I., Teshima H., Nolan M., Lapidus A., Tice H., Del Rio T.G., Cheng J.-F., Han C., Tapia R.,

Goodwin L.A., Pitluck S., Liolios K., Mavromatis K., Pagani I., Ivanova N., Mikhailova N., Pati A., Chen

A., Palaniappan K., Land M., *Rohde M., Lang E., (2013) Genome sequence of Frateuria aurantia type

strain (Kond+ 67T), a xanthomonade isolated from Lilium auratium Lindl Standards in Genomic

Sciences 9: 83 - 92.

*Bergmann S., *Rohde M., *Schughart K., Lengeling A. (2013) The bioluminescent Listeria

monocytogenes strain Xen32 is defective in flagella expression and highly attenuated in orally

infected BALB/cJ mice Gut Pathogens 5: 19.

74

Beyersmann P.G., Chertkov O., Petersen J., Fiebig A., Chen A., Pati A., Ivanova N., Lapidus A.,

Goodwin L.A., Chain P., Detter J.C., *Rohde M., Gronow S., Kyrpides N.C., Woyke T., Simon M., Göker

M., Klenk H.-P., Brinkhoff T. (2013) Genome sequence of Phaeobacter caeruleus type strain (DSM

24564T), a surface-associated member of the marine Roseobacter clade Standards in Genomic

Sciences 8.

Breider S., Teshima H., Petersen J., Chertkov O., Dalingault H., Chen A., Pati A., Ivanova N., Lapidus A.,

Goodwin L.A., Chain P., Detter J.C., *Rohde M., Tindall B.J., Kyrpides N.C., Woyke T., Simon M., Göker

M., Klenk H.P., Brinkhoff T. (2013) Genome sequence and emended description of Leisingera

nanhaiensis strain DSM 24252T isolated from marine sediment Standards in Genomic Sciences 9.

Chen H., Jogler M., *Rohde M., Klenk H.-P., Busse H.-J., Tindall B.J., Sproer C., Overmann J. (2013)

Sphingobium limneticum sp. nov. and Sphingobium boeckii sp. nov., two freshwater planktonic

members of the family Sphingomonadaceae, and reclassification of Sphingomonas suberifaciens as

Sphingobium suberifaciens comb. nov International Journal of Systematic and Evolutionary


Chen H., Jogler M., Tindall B.J., Klenk H.-P., *Rohde M., Busse H.-J., Overmann J. (2013)

Sphingomonas starnbergensis sp. nov., isolated from a prealpine freshwater lake International


del Carmen Montero-Calasanz M., Göker M., *Rohde M., Schumann P., Potter G., Sproer C.,

Gorbushina A.A., Klenk H.-P. (2013) Geodermatophilus siccatus sp. nov., isolated from arid sand of

the Saharan desert in Chad Antonie van Leeuwenhoek, International Journal of General and

Molecular Microbiology 103: 449 - 456.

Diekmann N., Burghartz M., Remus L., Kaufholz A.-L., Nawrath T., *Rohde M., Schulz S., Roselius L.,

Schaper J., Mamber O., Jahn D., Jahn M. (2013) Microbial communities related to volatile organic

compound emission in automobile air conditioning units Applied Microbiology and Biotechnology

97: 8777 - 8793.

Dogs M., Teshima H., Petersen J., Fiebig A., Chertkov O., Dalingault H., Chen A., Pati A., Goodwin L.A.,

Chain P., Detter J.C., Ivanova N., Lapidus A., *Rohde M., Gronow S., Kyrpides N.C., Woyke T., Simon

M., Göker M., Klenk H.-P., Brinkhoff T. (2013) Genome sequence of Phaeobacter daeponensis type

strain (DSM 23529T), a facultatively anaerobic bacterium isolated from marine sediment, and

emendation of Phaeobacter daeponensis Standards in Genomic Sciences 9: 142 - 159.

Dogs M., Voget S., Teshima H., Petersen J., Davenport K., Dalingault H., Chen A., Pati A., Ivanova N.,

Goodwin L.A., Chain P., Detter J.C., Standfest S., *Rohde M., Gronow S., Kyrpides N.C., Woyke T.,

Simon M., Klenk H.-P., Göker M., Brinkhoff T. (2013) Genome sequence of Phaeobacter inhibens type

strain (T5T), a secondary metabolite producing representative of the marine Roseobacter clade, and

emendation of the species description of Phaeobacter inhibens Standards in Genomic Sciences 9.

*Estrela A.B., *Rohde M., *Gutierrez M.G., *Molinari G., *Abraham W.-R. (2013) Human β-defensin 2

induces extracellular accumulation of adenosine in Escherichia coli Antimicrobial Agents and


Fiebig A., Pradella S., Petersen J., Michael V., Pauker O., *Rohde M., Göker M., Klenk H.-P., *Wagner-

75

Döbler I. (2013) Genome of the marine alphaproteobacterium Hoeflea phototrophica type strain

(DFL-43T) Standards in Genomic Sciences 7: 440 - 448.

Foesel B.U., *Rohde M., Overmann J. (2013) Blastocatella fastidiosa gen. nov., sp. nov., isolated from

semiarid savanna soil - The first described species of Acidobacteria subdivision 4 Systematic and

Applied Microbiology 36: 82 - 89.

Freese H.M., Dalingault H., Petersen J., Pradella S., Davenport K., Teshima H., Chen A., Pati A.,

Ivanova N., Goodwin L.A., Chain P., Detter J.C., *Rohde M., Gronow S., Kyrpides N.C., Woyke T.,

Brinkhoff T., Göker M., Overmann J., Klenk H.-P. (2013) Genome sequence of the phage-gene rich

marine Phaeobacter arcticus type strain DSM 23566T Standards in Genomic Sciences 8.

*Fulde M., *Rohde M., *Polok A., Preissner K.T., *Chhatwal G.S., *Bergmann S. (2013) Cooperative

plasminogen recruitment to the surface of Streptococcus canis via M protein and enolase enhances

bacterial survival mBio 4.

*Fulde M., Bernardo-Garcia N., *Rohde M., *Nachtigall N., *Frank R., Preissner K.T., Klett J., Morreale

A., *Singh Chhatwal G., Hermoso J.A., *Bergmann S. (2013) Pneumococcal phosphoglycerate kinase

interacts with plasminogen and its tissue activator Thrombosis and Haemostasis 111: 401 - 416.

*Hitzmann A., *Bergmann S., *Rohde M., *Chhatwal G.S., *Fulde M. (2013) Identification and

characterization of the arginine deiminase system of Streptococcus canis Veterinary Microbiology

162: 270 - 277.

Huntemann M., Stackebrandt E., Held B., Nolan M., Lucas S., Hammon N., Deshpande S., Cheng J.-F.,

Tapia R., Goodwin L.A., Pitluck S., Liolios K., Pagani I., Ivanova N., Mavromatis K., Mikhailova N., Pati

A., Chen A., Palaniappan K., Land M., *Rohde M., Gr (2013) Genome sequence of the phylogenetically

isolated spirochete Leptonema illini type strain (3055T) Standards in Genomic Sciences 8: 177 - 187.

Jogler M., Chen H., Simon J., *Rohde M., Busse H.-J., Klenk H.-P., Tindall B.J., Overmann J. (2013)

Description of Sphingorhabdus planktonica gen. nov., sp. nov. and reclassification of three related

members of the genus Sphingopyxis in the genus Sphingorhabdus gen. nov International Journal of


Meier-Kolthoff J.P., Lu M., Huntemann M., Lucas S., Lapidus A., Copeland A., Pitluck S., Goodwin L.A.,

Han C., Tapia R., Potter G., Land M., Ivanova N., *Rohde M., Göker M., Detter J.C., Woyke T., Kyrpides

N.C., Klenk H.-P. (2013) Genome sequence of the chemoheterotrophic soil bacterium

Saccharomonospora cyanea type strain (NA-134T) Standards in Genomic Sciences 9: 28 - 41.

Montero-Calasanz M.C., Göker M., *Rohde M., Sproer C., Schumann P., Busse H.-J., Schmid M.,

Tindall B.J., Klenk H.-P., Camacho M. (2013) Chryseobacterium hispalense sp. nov., a plantgrowth-

promoting bacterium isolated from a rainwater pond in an olive plant nursery, and emended

descriptions of Chryseobacterium defluvii, Chryseobacterium indologenes, Chryseobacterium

wanjuense and Chryseob International Journal of Systematic and Evolutionary Microbiology 63:

4386 - 4395.

Montero-Calasanz M.C., Göker M., Potter G., *Rohde M., Sproer C., Schumann P., Gorbushina A.A.,

Klenk H.-P. (2013) Geodermatophilus saharensis sp. nov., isolated from sand of the Saharan desert in

76

Chad Archives of Microbiology 195: 153 - 159.

Montero-Calasanz M.C., Göker M., Potter G., *Rohde M., Sproer C., Schumann P., Gorbushina A.A.,

Klenk H.-P. (2013) Geodermatophilus normandii sp. nov., isolated from Saharan desert sand


Montero-Calasanz M.C., Göker M., Potter G., *Rohde M., Sproer C., Schumann P., Klenk H.-P.,

Gorbushina A.A. (2013) Geodermatophilus telluris sp. nov., an actinomycete isolated from Saharan

desert sand International Journal of Systematic and Evolutionary Microbiology 63: 2254 - 2259.

Montero-Calasanz M.D.C., Göker M., Broughton W.J., Cattaneo A., Favet J., Potter G., *Rohde M.,

Sproer C., Schumann P., Klenk H.-P., Gorbushina A.A. (2013) Geodermatophilus tzadiensis sp. nov., a

UV radiation-resistant bacterium isolated from sand of the Saharan desert Systematic and Applied


Montero-Calasanz M.D.C., Göker M., Potter G., *Rohde M., Sproer C., Schumann P., Gorbushina A.A.,

Klenk H.-P. (2013) Geodermatophilus africanus sp. nov., a halotolerant actinomycete isolated from

Saharan desert sand Antonie van Leeuwenhoek, International Journal of General and Molecular


Palaniappan K., Meier-Kolthoff J.P., Teshima H., Nolan M., Lapidus A., Tice H., Del Rio T.G., Cheng J.-

F., Han C., Tapia R., Goodwin L.A., Pitluck S., Liolios K., Mavromatis K., Pagani I., Ivanova N.,

Mikhailova N., Pati A., Chen A., *Rohde M., Mayilraj S (2013) Genome sequence of the moderately

thermophilic sulfur-reducing bacterium Thermanaerovibrio velox type strain (Z-9701T) and emended

description of the genus Thermanaerovibrio Standards in Genomic Sciences 9: 57 - 70.

*Patzelt D., *Wang H., Buchholz I., *Rohde M., Grobe L., Pradella S., Neumann A., Schulz S., Heyber

S., Münch K., Münch R., Jahn D., *Wagner-Dobler I., *Tomasch J. (2013) You are what you talk:

Quorum sensing induces individual morphologies and cell division modes in Dinoroseobacter shibae

ISME Journal 7: 2274 - 2286.

Rahim M.I.*, *Mueller P.P., *Rohde M., *Hauser H. (2013) Evaluation and comparison of in vitro and

in vivo degradation kinetics of magnesium Biomedizinische Technik 58.

*Riedel T., Teshima H., Petersen J., Fiebig A., Davenport K., Daligault H., Erkkila T., Gu W., Munk C.,

Xu Y., Chen A., Pati A., Ivanova N., Goodwin L.A., Chain P., Detter J.C., *Rohde M., Gronow S.,

Kyrpides N.C., Woyke T., Göker M., Brinkhoff T., Klenk (2013) Genome sequence of the Leisingera

aquimarina type strain (DSM 24565T), a member of the marine Roseobacter clade rich in extra

chromosomal elements Standards in Genomic Sciences 8.

*Rohde M., *Chhatwal G.S. (2013) Adherence and invasion of streptococci to eukaryotic cells and

their role in disease pathogenesis Current Topics in Microbiology and Immunology 368: 83 - 110.

*Schaake J., *Kronshage M., *Uliczka F., *Rohde M., *Knuuti T., Strauch E., Fruth A., *Wos-Oxley M.,

*Dersch P. (2013) Human and animal isolates of Yersinia enterocolitica show significant serotype-

specific colonization and host-specific immune defense properties Infection and Immunity 81: 4013 -

4025.

77

*Schwerk J.,* Köster M., *Hauser H., *Rohde M., Fulde M., Hornef M.W., May T. (2013) Generation

of Mouse Small Intestinal Epithelial Cell Lines That Allow the Analysis of Specific Innate Immune

Functions PLoS ONE 8: e72700.

Seitz M., Baums C.G., Neis C., Benga L., *Fulde M., *Rohde M., Goethe R., Valentin-Weigand P. (2013)

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*Behrendt P., Bremer B., *Todt D.,* Brown R.J.P., Heim A., Manns M.P., *Steinmann E., Wedemeyer H. (2016) Hepatitis e Virus (HEV) ORF2 Antigen Levels Differentiate between Acute and Chronic HEV Infection Journal of Infectious Diseases 214: 361 - 368.

*Drave S.A., Debing Y., *Walter S., *Todt D., *Engelmann M., *Friesland M., Wedemeyer H., Neyts J., *Behrendt P., *Steinmann E. (2016) Extra-hepatic replication and infection of hepatitis E virus in neuronal-derived cells Journal of Viral Hepatitis 23: 512 - 521. Gather T., *Walter S., *Pfaender S., *Todt D., Feige K., *Steinmann E., Cavalleri J.M.V. (2016) Acute and chronic infections with nonprimate hepacivirus in young horses Veterinary Research 47: 1 - 5. Gather T., *Walter S., *Todt D., *Pfaender S., *Brown R.J.P., Postel A., Becher P., Moritz A., Hansmann F., Baumgaertner W., Feige K., *Steinmann E., Cavalleri J.-M.V. (2016) Vertical transmission of hepatitis C virus-like nonprimate hepacivirus in horses Journal of General Virology 97: 2540 - 2551. *Heidrich B., *Steinmann E., *Plumeier I., Kirschner J., Sollik L., Ziegert S., *Engelmann M., Lehmann P., Manns M.P., *Pieper D.H., Wedemeyer H. (2016) Frequent detection of HCV RNA and HCVcoreAg in stool of patients with chronic hepatitis C Journal of Clinical Virology 80: 1 - 7. Ionidis G., Hübscher J., Jack T., Becker B., Bischoff B., *Todt D., Hodasa V., Brill F.H.H., *Steinmann E., Steinmann J. (2016) Development and virucidal activity of a novel alcohol-based hand disinfectant supplemented with urea and citric acid BMC Infectious Diseases 16: 77. Klotz U., Schmidt D., Willinger B., *Steinmann E., Buer J., Rath P.-M., Steinmann J. (2016) Echinocandin resistance and population structure of invasive Candida glabrata isolates from two university hospitals in Germany and Austria Mycoses 59: 312 - 318. Krull M., Klare I., Ross B., Trenschel R., Beelen D.W., *Todt D., *Steinmann E., Buer J., Rath P.-M., Steinmann J. (2016) Emergence of linezolid- and vancomycin-resistant Enterococcus faecium in a department for hematologic stem cell transplantation Antimicrobial Resistance and Infection Control 5: 31. *Pfaender S., *Grabski E., *Detje C.N., *Riebesehl N., *Lienenklaus S., *Steinmann E., *Kalinke U., *Pietschmann T. (2016) Hepatitis C Virus Stimulates Murine CD8a-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner PLoS Pathogens 12: e1005736. *Pfaender S., von Hahn T., Steinmann J., Ciesek S., *Steinmann E. (2016) Prevention strategies for blood-borne viruses-in the Era of vaccines, direct acting antivirals and antiretroviral therapy Reviews in Medical Virology 26: 330 - 339. Postel A., Cavalleri J.M.V., *Pfaender S., *Walter S., *Steinmann E., Fischer N., Feige K., Haas L., Becher P. (2016) Frequent presence of hepaci and pegiviruses in commercial equine serum pools Veterinary Microbiology 182: 8 - 14. *Siddharta A., *Pfaender S., *Malassa A., *Doerrbecker J., *Anggakusuma A., *Engelmann M., Nugraha B., Steinmann J., *Todt D., Vondran F.W.R., Mateu-Gelabert P., *Goffinet C., *Steinmann E. (2016) Inactivation of HCV and HIV by microwave: A novel approach for prevention of virus transmission among people who inject drugs Scientific Reports 6: 36619. Stohr S., Costa R., Sandmann L., Westhaus S., *Pfaender S., *Anggakusuma, Dazert E., Meuleman P.,

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Vondran F.W.R., Manns M.P., *Steinmann E., von Hahn T., Ciesek S. (2016) Host cell mTORC1 is required for HCV RNA replication Gut 65: 2017 - 2028. *Todt D., *Walter S., *Brown R.J.P., *Steinmann E. (2016) Mutagenic effects of ribavirin on hepatitis E virus-viral extinction versus selection of fitness-enhancing mutations Viruses 8: 283. *Todt D., François C., *Anggakusuma, *Behrendt P., *Engelmann M., *Knegendorf L., *Vieyres G., Wedemeyer H., Hartmann R., *Pietschmann T., Duverlie G., *Steinmann E. (2016) Antiviral activities of different interferon types and subtypes against Hepatitis E virus replication Antimicrobial Agents and Chemotherapy 60: 2132 - 2139. *Todt D., Gisa A., Radonic A., Nitsche A., *Behrendt P., Suneetha P.V., Pischke S., Bremer B., *Brown R.J., Manns M.P., Cornberg M., Bock C.T., *Steinmann E., Wedemeyer H. (2016) In vivo evidence for Ribavirin-induced mutagenesis of the hepatitis E virus genome Gut 65: 1733 - 1743. Walker A., Skibbe K., *Steinmann E., *Pfaender S., Kuntzen T., Megger D.A., Groten S., Sitek B., Lauer G.M., Kim A.Y., *Pietschmann T., Allen T.M., Timm J. (2016) Distinct escape pathway by hepatitis C virus genotype 1a from a dominant CD8+ T cell response by selection of altered epitope processing Journal of Virology 90: 33 - 42. *Walter S., *Bollenbach A., *Doerrbecker J., *Pfaender S., *Brown R.J.P., *Vieyres G., Scott C., Foster R., Kumar A., Zitzmann N., Griffin S., Penin F., *Pietschmann T., *Steinmann E. (2016) Ion channel function and cross-species determinants in viral assembly of nonprimate hepacivirus p7 Journal of Virology 90: 5075 - 5089.

*Weller R., *Todt D., *Engelmann M., *Friesland M., Wedemeyer H., *Pietschmann T., *Steinmann E. (2016) Apolipoprotein E polymorphisms and their protective effect on hepatitis E virus replication Hepatology 64: 2274 - 2276. *Anggakusuma, *Frentzen A., Gurlevik E., *Yuan Q., *Steinmann E., *Ott M., Staeheli P., Schmid-Burgk J., Schmidt T., Hornung V., Kuehnel F., *Pietschmann T. (2015) Control of hepatitis C virus replication in mouse liver-derived cells by MAVS-dependent production of type I and type III interferons Journal of Virology 89: 3833 - 3845. *Anggakusuma., Romero-Brey I., Berger C., Colpitts C.C., Boldanova T., *Engelmann M., *Todt D., *Perin P.M., *Behrendt P., Vondran F.W., Xu S., *Goffinet C., Schang L.M., Heim M.H., Bartenschlager R., *Pietschmann T., *Steinmann E. (2015) Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication via blockage of membranous web formation Hepatology 62: 702 - 714. Garcia-Risco M.R., Vazquez E., *Sheldon J., *Steinmann E., *Riebesehl N., Fornari T., Reglero G. (2015) Supercritical fluid extraction of heather (Calluna vulgaris) and evaluation of anti-hepatitis C virus activity of the extracts Virus Research 198: 9 - 14. *Grabski E., *Wappler I., *Pfaender S., *Steinmann E., *Haid S., Dzionek A., *Pietschmann T., *Kalinke U. (2015) Efficient virus assembly, but not infectivity, determines the magnitude of hepatitis C virus-induced interferon alpha responses of plasmacytoid dendritic cells Journal of Virology 89: 3200 - 3208. *Pfaender S., *Brinkmann J., *Todt D., *Riebesehl N., Steinmann J., Steinmann J., *Pietschmann T., *Steinmann E. (2015) Mechanisms of methods for hepatitis C virus inactivation Applied and Environmental Microbiology 81: 1616 - 1621.

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*Pfaender S., *Walter S., *Todt D., *Behrendt P., *Doerrbecker J., Wolk B., *Engelmann M., Gravemann U., Seltsam A., Steinmann J., Burbelo P.D., *Klawonn F., Feige K., *Pietschmann T., Cavalleri J.-M.V., *Steinmann E. (2015) Assessment of cross-species transmission of hepatitis C virus-related non-primate hepacivirus in a population of humans at high risk of exposure Journal of General Virology 96: 2636 - 2642. *Pfaender S., Cavalleri J.M., *Walter S., *Doerrbecker J., Campana B., *Brown R.J., Burbelo P.D., Postel A., Hahn .K, *Anggakusuma, *Riebesehl N., Baumgärtner W., Becher P., Heim M.H., *Pietschmann T., Feige K., *Steinmann E. (2015) Clinical course of infection and viral tissue tropism of hepatitis C virus-like nonprimate hepaciviruses in horses Hepatology 61: 447 - 459. Rabenau H.F., Schwebke I., Blümel J., Eggers M., Glebe D., Rapp I., Sauerbrei A., *Steinmann E., Steinmann J., Willkommen H., Wutzler P., (2015) Leitlinie der Deutschen Vereinigung zur Bekämpfung der Viruskrankheiten (DVV) e. V. und des Robert Koch-Instituts (RKI) zur Prüfung von chemischen Desinfektionsmitteln auf Wirksamkeit gegen Viren in der Humanmedizin : Fassung vom 1. Dezember 2014 Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 58: 493 - 504. Rath P.-M., Schoch B., Adamzik M., *Steinmann E., Buer J., Steinmann J. (2015) Reply: PCR assay for pathogen detection in ventriculostomy-related meningitis in neurosurgery patients: unanswered questions? Infection 43: 251 - 252. Schwebke I., Blümel J., Eggers M., Glebe D., Rapp I., Von Rheinbaben F., Sauerbrei A., *Steinmann E., Steinmann J., Willkommen H., Wutzler P., Rabenau H.F. (2015) Communication of the German Registered Association for Combating Viral Diseases (DVV) and the Robert Koch Institute (RKI) on the publication of the updated version of the Guideline for Testing Chemical Disinfectants for Efficacy against Viruses in Human M Hygiene + Medizin 40: 254 - 255. Steinmann J., Becker B., Bischoff B., *Steinmann E. (2015) Alcohol hand rub or soap and water for removal of norovirus from hands - the debate continues Journal of Hospital Infection 91: 371 - 372. Tarr A.W., *Khera T., *Hueging K., *Sheldon J., *Steinmann E., *Pietschmann T., *Brown R.J.P. (2015) Genetic diversity underlying the envelope glycoproteins of hepatitis C virus: Structural and functional consequences and the implications for vaccine design Viruses 7: 3995 - 4046. *Anggakusuma, Colpitts C.C., Schang L.M., Rachmawati H., *Frentzen A., *Pfaender S., *Behrendt P., *Brown R.J.P., *Bankwitz D., Steinmann J., *Ott M., Meuleman P., Rice C.M., Ploss A., *Pietschmann T., *Steinmann E. (2014) Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells Gut 63: 1137 - 1149. *Behrendt P., *Steinmann E., Manns M.P., Wedemeyer H. (2014) The impact of hepatitis e in the liver transplant setting Journal of Hepatology 61: 1418 - 1429. Deest M., Westhaus S., *Steinmann E., Manns M.P., von Hahn T., Ciesek S. (2014) Impact of single nucleotide polymorphisms in the essential HCV entry factor CD81 on HCV infectivity and neutralization Antiviral Research 101: 37 - 44. *Doerrbecker J., *Friesland M., *Riebesehl N., *Ginkel C., *Behrendt P., *Brown R.J., *Ciesek S., Wedemeyer H., Sarrazin C., Kaderali L., *Pietschmann T., *Steinmann E. (2014) Incorporation of primary patient-derived glycoproteins into authentic infectious hepatitis C virus particles Hepatology 60: 508 - 520.

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Irving W.L., Rupp D., McClure C.P., Than L.M., Titman A., Ball J.K., *Steinmann E., Bartenschlager R., *Pietschmann T., Brown R.J.P. (2014) Development of a high-throughput pyrosequencing assay for monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus protease coding-region Antiviral Research 110: 52 - 59. *Pfaender S., *Brown R.J.P., *Pietschmann T., *Steinmann E. (2014) Natural reservoirs for homologs of hepatitis C virus Emerging Microbes and Infections 3: e21 - . Rath P.-M., Schoch B., Adamzik M., *Steinmann E., Buer J., Steinmann J. (2014) Value of multiplex PCR using cerebrospinal fluid for the diagnosis of ventriculostomy-related meningitis in neurosurgery patients Infection 42: 621 - 627. Vidigal P.G., *Musken M., Becker K.A., *Haussler S., Wingender J., *Steinmann E., *Kehrmann J., Gulbins E., Buer J., Rath P.M., Steinmann J. (2014) Effects of green tea compound Epigallocatechin-3-gallate against Stenotrophomonas maltophilia infection and biofilm PLoS ONE 9: e92876. Vidigal P.G., Dittmer S., *Steinmann E., Buer J., Rath P.-M., Steinmann J. (2014) Adaptation of Stenotrophomonas maltophilia in cystic fibrosis: Molecular diversity, mutation frequency and antibiotic resistance International Journal of Medical Microbiology 304: 613 - 619. *Behrendt P., *Doerrbecker J., *Riebesehl N., *Wilhelm C., *Ciesek S., Erichsen T.J., Steinmann J., Ott M., Manns M.P., *Pietschmann T., *Steinmann E. (2013) Stability and transmission of hepatitis C virus in different anesthetic agents American Journal of Infection Control 41: 942 - 943. *Doerrbecker J., *Behrendt P., Mateu-Gelabert P., *Ciesek S., *Riebesehl N., *Wilhelm C., Steinmann J., *Pietschmann T., *Steinmann E. (2013) Transmission of hepatitis C virus among people who inject drugs: Viral stability and association with drug preparation equipment Journal of Infectious Diseases 207: 281 - 287. *Doerrbecker J., Meuleman P., Kang J., *Riebesehl N., *Wilhelm C., *Friesland M., *Pfaender S., Steinmann J., *Pietschmann T., *Steinmann E. (2013) Thermostability of seven hepatitis C virus genotypes in vitro and in vivo Journal of Viral Hepatitis 20: 478 - 485. *Gentzsch J., *Brohm C., *Steinmann E., *Friesland M., *Menzel N., *Vieyres G., *Perin P.M., *Frentzen A., Kaderali L., *Pietschmann T. (2013) Hepatitis C Virus p7 is Critical for Capsid Assembly and Envelopment PLoS Pathogens 9: e1003355. *Nandakumar R., *Finsterbusch K., *Lipps C., *Neumann B., *Grashoff M., *Nair S., *Hochnadel I., *Lienenklaus S., *Wappler I., *Steinmann E., *Hauser H., *Pietschmann T., *Kroger A. (2013) Hepatitis C virus replication in mouse cells is restricted by IFN-dependent and -independent mechanisms Gastroenterology 145: 1414 - 1423.e1. *Pfaender S., *Heyden J., *Friesland M., Ciesek S., Ejaz A., Steinmann J., Steinmann J., Malarski A., Stoiber H., Tsiavaliaris G., Bader W., Jahreis G., *Pietschmann T., *Steinmann E. (2013) Inactivation of hepatitis C virus infectivity by human breast milk Journal of Infectious Diseases 208: 1943 - 1952. Schemuth H., Dittmer S., Lackner M., Sedlacek L., Hamprecht A., *Steinmann E., Buer J., Rath P.-M., Steinmann J. (2013) In vitro activity of colistin as single agent and in combination with antifungals against filamentous fungi occurring in patients with cystic fibrosis Mycoses 56: 297 - 303. Steinmann J., Becker B., Bischoff B., Magulski T., Steinmann J., *Steinmann E. (2013) Virucidal activity of Formulation I of the World Health Organization's alcohol-based handrubs: Impact of changes in

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key ingredient levels and test parameters Antimicrobial Resistance and Infection Control 2: 34. Steinmann J., Buer J., *Pietschmann T., *Steinmann E. (2013) Anti-infective properties of Epigallocatechin-3-gallate (EGCG), a component of green tea British Journal of Pharmacology 168: 1059 - 1073. *Steinmann E., *Doerrbecker J., *Friesland M., *Riebesehl N., *Ginkel C., *Hillung J., *Gentzsch J., Lauber C, *Brown R., *Frentzen A., *Pietschmann T. (2013) Characterization of hepatitis C virus intra- and intergenotypic chimeras reveals a role of the glycoproteins in virus envelopment Journal of Virology 87: 13297 - 13306. *Steinmann E., *Gravemann U., *Friesland M., *Doerrbecker J., *Muller T.H., *Pietschmann T., *Seltsam A. (2013) Two pathogen reduction technologies - Methylene blue plus light and shortwave ultraviolet light - Effectively inactivate hepatitis C virus in blood products Transfusion 53: 1010 - 1018. *Steinmann E., *Pietschmann T. (2013) Cell culture systems for hepatitis C virus Current Topics in Microbiology and Immunology 369: 17 - 48. *Vieyres G., *Brohm C., *Friesland M., *Gentzsch J., Wolk B., Roingeard P., *Steinmann E., *Pietschmann T. (2013) Subcellular localization and function of an epitope-tagged p7 viroporin in hepatitis C virus-producing cells Journal of Virology 87: 1664 - 1678. Vidigal P.G., Schmidt D., Stehling F., Mellies U., *Steinmann E., Buer J., Rath P.-M., Steinmann J. (2013) Development of a quantitative immunofluorescence assay for detection of Stenotrophomonas maltophilia antibodies in patients with cystic fibrosis Journal of Cystic Fibrosis 12: 651 - 654.

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Stradal, Theresia

Schnoor M., *Stradal T.E.B., *Rottner K. (2017) Cortactin: Cell Functions of A Multifaceted Actin-Binding Protein Trends in Cell Biology doi: 10.1016/j.tbc.2017.10.009. Böttcher R.T., Veelders M., Rombaut P., Faix J., Theodosiou M., *Stradal T.E.B., *Rottner K., Zent R., Herzog F., Fässler R. (2017) Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading Journal of Cell Biology 216: 3785 - 3798. Litschko C., Linkner J., Brühmann S., *Stradal T.E.B., *Reinl T., *Jänsch L., *Rottner K., Faix J. (2017) Differential functions of WAVE regulatory complex subunits in the regulation of actin-driven processes European Journal of Cell Biology 96: 715 - 727. *Kage F., *Steffen A., Ellinger A., Ranftler C., *Gehre C., Brakebusch C., Pavelka M., *Stradal T., *Rottner K. (2017) FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42 Scientific Reports 7: 9791. Noumeur S.R.*, *Helaly S.E., *Jansen R., *Gereke M., *Stradal T.E.B., Harzallah D., *Stadler M. (2017) Preussilides A-F, Bicyclic Polyketides from the Endophytic Fungus Preussia similis with Antiproliferative Activity Journal of Natural Products 80: 1531 - 1540. *Kage F., Winterhoff M., *Dimchev V., Mueller J., *Thalheim T., *Freise A., Brühmann S., *Kollasser J., *Block J., *Dimchev G., Geyer M., Schnittler H.-J., Brakebusch C., *Stradal T.E.B., Carlier M.-F., Sixt M., Käs J., Faix J., *Rottner K. (2017) FMNL formins boost lamellipodial force generation Nature Communications 8: 14832. *Horstmann J.A., *Zschieschang E., Truschel T., *de Diego J., *Lunelli M., *Rohde M., May T., *Strowig T., *Stradal T.E.B., *Kolbe M., *Erhardt M. (2017) Flagellin phase-dependent swimming on epithelial cell surfaces contributes to productive Salmonella gut colonisation Cellular Microbiology 19: e12739. *Steffen A., *Stradal T.E.B., *Rottner K. (2017) Signalling pathways controlling cellular actin organization Handbook of Experimental Pharmacology 235: 153 - 178. Leithner A., Eichner A., Müller J., Reversat A., Brown M., Schwarz J., Merrin J., De Gorter D.J.J., Schur F., Bayerl J., De Vries I., Wieser S., Hauschild R., *Lai F.P.L., Moser M., Kerjaschki D., *Rottner K., Small J.V., *Stradal T.E.B., Sixt M. (2016) Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes Nature Cell Biology 18: 1253 - 1259. *Stradal T.E.B., *Costa S.C.P. (2016) Type III secreted virulence factors manipulating signaling to actin dynamics Current Topics in Microbiology and Immunology 399: 175 - 199. Thiam H.-R., Vargas P., Carpi N., Crespo C.L., Raab M., Terriac E., King M.C., Jacobelli J., Alberts A.S., *Stradal T.E.B., Lennon-Dumenil A.-M., Piel M. (2016) Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments Nature Communications 7: 10997. *Rottner K., *Stradal T.E.B. (2016) How distinct Arp2/3 complex variants regulate actin filament assembly Nature Cell Biology 18: 1 - 3. Blasche S., Arens S., Ceol A., Siszler G., Schmidt M.A., Häuser R., Schwarz F., Wuchty S., Aloy P., Uetz P., *Stradal T.E.B., Koegl M. (2014) The EHEC-host interactome reveals novel targets for the translocated intimin receptor Scientific Reports 4: 7531.

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Tawk C., Sharan M., Eulalio A., *Vogel J. (2017) A systematic analysis of the RNA-targeting potential

of secreted bacterial effector proteins Scientific Reports 7: 9328.

Gonzalez GM., Hardwick SW., Maslen SL., Skehel JM., Holmqvist E., *Vogel J., Bateman A., Luisi BF.,

Broadhurst RW. (2017) Structure of the Escherichia coli ProQ RNA-binding protein RNA 23: 696 - 711.

Hör J., *Vogel J. (2017) Global snapshots of bacterial RNA networks EMBO Journal 36: 245 - 247.

Gorski SA., *Vogel J., Doudna JA. (2017) RNA-based recognition and targeting: sowing the seeds of

specificity Nature Reviews Molecular Cell Biolology 18: 215 - 228.

*Westermann AJ., *Barquist L., *Vogel J. (2017) Resolving host-pathogen interactions by dual RNA-

seq PLoS Pathogens 13: e1006033.

Publications before start at the HZI

Saliba A.-E., C Santos S., Vogel J. (2017) New RNA-seq approaches for the study of bacterial

pathogens Current Opinion in Microbiology 35: 78 – 87.

Westermann AJ., Förstner KU., Amman F., Barquist L., Chao Y., Schulte LN., Müller L., Reinhardt R.,

Stadler PF., Vogel J. (2016) Dual RNA-seq unveils noncoding RNA functions in host-pathogen

96

interactions Nature 529:496-501.

Smirnov A., Förstner KU., Holmqvist E., Otto A., Günster R., Becher D., Reinhardt R., Vogel J. (2016)

Grad-seq guides the discovery of ProQ as a major small RNA binding protein PNAS 113:11591-11596.

Holmqvist E., Wright PR., Li L., Bischler T., Barquist L., Reinhardt R., Backofen R., Vogel J. (2016)

Global RNA recognition patterns of post-transcriptional regulators Hfq and CsrA revealed by UV

crosslinking in vivo EMBO Journal 35:991-1011.

Chao Y., Vogel J. (2016) A 3’UTR derived small RNA provides the regulatory noncoding arm of the

inner membrane stress response Molecular Cell 61:352-363.

Fröhlich KS., Haneke K., Papenfort K., Vogel J. (2016) The target spectrum of SdsR small RNA in

Salmonella Nucleic Acids Research 44: 10406-10422.

Das S., Lindemann C., Young BC., Muller J., Österreich B., Ternette N., Winkler AC., Paprotka K.,

Reinhardt R., Förstner KU., Allen E., Flaxman A., Yamaguchi Y., Rollier CS., van Diemen P., Blättner S.,

Remmele CW., Selle M., Dittrich M., Mueller T., Vogel J., Ohlsen K., Crook DW., Massey R., Wilson DJ.,

Rudel R., Wyllie DH., Fraunholz MJ. (2016) Natural mutations in a S. aureus virulence regulator

attenuate cytotoxicity but permit bacteremia and abscess formation PNAS 113:E3101–E3110.

Jiang Y., Oron TR., Clark WT., Bankapur AR., D'Andrea D., Lepore R., Funk CS., Kahanda I., Verspoor

KM., Ben-Hur A., Koo da CE., Penfold-Brown D., Shasha D., Youngs N., Bonneau R., Lin A, Sahraeian

SM., Martelli PL., Profiti G., Casadio R., Cao R., Zhong Z., Cheng J., Altenhoff A., Skunca N., Dessimoz

C., Dogan T., Hakala K., Kaewphan S., Mehryary F., Salakoski T., Ginter F., Fang H., Smithers B., Oates

M., Gough J., Törönen P., Koskinen P., Holm L., Chen CT., Hsu WL., Bryson K., Cozzetto D., Minneci F.,

Jones DT., Chapman S., Bkc D., Khan IK., Kihara D., Ofer D., Rappoport N., Stern A., Cibrian-Uhalte E.,

Denny P., Foulger RE., Hieta R., Legge D., Lovering RC., Magrane M., Melidoni AN., Mutowo-

Meullenet P., Pichler K., Shypitsyna A., Li B., Zakeri P., ElShal S., Tranchevent LC., Das S., Dawson NL.,

Lee D., Lees JG., Sillitoe I., Bhat P., Nepusz T., Romero AE., Sasidharan R., Yang H., Paccanaro A., Gillis

J., Sedeño-Cortés AE., Pavlidis P., Feng S., Cejuela JM., Goldberg T., Hamp T., Richter L., Salamov A.,

Gabaldon T., Marcet-Houben M., Supek F., Gong Q., Ning W., Zhou Y., Tian W., Falda M., Fontana P.,

Lavezzo E., Toppo S., Ferrari C., Giollo M., Piovesan D., Tosatto SC., Del Pozo A., Fernández JM.,

Maietta P., Valencia A., Tress ML., Benso A., Di Carlo S., Politano G., Savino A., Rehman HU., Re M.,

Mesiti M., Valentini G., Bargsten JW., van Dijk AD., Gemovic B., Glisic S., Perovic V., Veljkovic V.,

Veljkovic N., Almeida-E-Silva DC., Vencio RZ., Sharan M., Vogel J., Kansakar L., Zhang S., Vucetic S.,

Wang Z., Sternberg MJ., Wass MN., Huntley RP., Martin MJ., O'Donovan C., Robinson PN., Moreau Y.,

Tramontano A., Babbitt PC., Brenner SE., Linial M., Orengo CA., Rost B., Greene CS., Mooney SD.,

Friedberg I., Radivojac P. (2016) An expanded evaluation of protein function prediction methods

shows an improvement in accuracy Genome Biology 17:184.

Hershko-Shalev T., Odenheimer-Bergman A., Elgrably-Weiss M., Ben-Zvi T., Govindarajan S., Seri H.,

Papenfort K., Vogel J., Altuvia S. (2016) Gifsy-1 prophage IsrK with dual function as small and

messenger RNA modulates vital bacterial machineries PLoS Genetics 12:e1005975.

Müller AA., Dolowschiak T., Sellin ME., Felmy B., Verbree C., Gadient S., Westermann AJ., Vogel J.,

LeibundGut-Landmann S., Hardt WD. (2016) An NK cell perforin response elicited via IL-18 controls

mucosal inflammation kinetics during Salmonella gut infection PLoS Pathogens 12:e1005723.

97

Berger P., Knödler M., Förstner KF., Berger M., Bertling C., Sharma CM., Vogel J., Karch H., Dobrindt

U., Mellmann A. (2016) The primary transcriptome of the E. coli O104:H4 pAA plasmid and novel

insights into its virulence gene expression and regulation Scientific Reports 6:35307.

Cao Y., Förstner KU., Vogel J., Smith J. (2016) Cis-encoded sRNAs, a conserved mechanism for

repression of polysaccharide utilization in the Bacteroides Journal of Bacteriology 198:2410-2418.

Barquist L., Westermann AJ., Vogel J. (2016) Molecular phenotyping of infection-associated small

noncoding RNAs Philosophical Transactions B 371(1707):20160081.

Marbaniang CM., Vogel J. (2016) Emerging roles of RNA modifications in bacteria Current Opinion

Microbiology 30:50-57.

Papenfort K., Espinosa E., Casadesús J., Vogel J. (2015) Small RNA-based feed-forward loop with AND-

gate logic regulates extrachromosomal DNA transfer in Salmonella PNAS 112(34):E4772-4781

Miyakoshi M., Chao Y., Vogel J. (2015) Crosstalk between ABC transporter mRNAs via a target

mRNA-derived sponge of the GcvB small RNA EMBO Journal 34:1478-1492.

Heidrich N., Dugar G., Vogel J., Sharma CM (2014) Investigating CRISPR RNA biogenesis and function

using RNA-seq Methods in Molecular Biology 1311:1-21.

Sass A., Van Acker H., Förstner KU., Van Nieuwerburgh F., Deforce D., Vogel J., Coenye T (2015)

Genome-wide transcription start site profiling in biofilm-grown Burkholderia cenocepacia J2315 BMC

Genomics 16:775.

Afonso-Grunz F., Hoffmeier K., Müller S., Westermann AJ., Rotter B., Vogel J., Winter P., Kahl G.

(2015) Dual 3´Seq using deepSuperSAGE uncovers transcriptomes of interacting Salmonella enterica

Typhimurium and human host cells BMC Genomics 16:323.

Fan B., Li L., Chao Y., Jiang CL., Förstner KU., Vogel J., Borriss .B, Wu XQ. (2015) dRNA-seq reveals

genomewide TSSs and noncoding RNAs of plant beneficial rhizobacterium Bacillus amyloliquefaciens

FZB42 PLoS One 10:e0142002.

Ziebuhr W, Vogel J. (2015) The end is not the end: remnants of tRNA precursors live on to sponge up

small regulatory RNAs Molecular Cell 58:389-390.

Barquist L., Vogel J. (2015) Accelerating discovery and functional analysis of small RNAs with new

technologies Annual Review of Genetics 49:367-394.

Miyakoshi M., Chao Y., Vogel J. (2015) Regulatory small RNAs from the 3’ regions of bacterial mRNAs

Current Opinion in Microbiology 24:132-139.

Vogel J. (2014) A bacterial seek-and-destroy system for foreign DNA Science 344:972-973.

Dimastrogiovanni D., Fröhlich KS., Bandyra KJ., Bruce HA., Hohensee S., Vogel J., Luisi BF. (2014)

Recognition of the small regulatory RNA RydC by the bacterial Hfq protein eLife 3:e05375.

98

Saliba AE., Westermann AJ., Gorski SA., Vogel J. (2014) Single-cell RNA-seq: advances and future

challenges Nucleic Acids Research 42:8845-8860.

Sharma CM., Vogel J. (2014) Differential RNA-seq: the approach behind and the biological insight

gained Current Opinion in Microbiology 19:97-105.

Papenfort K., Vogel J. (2014) Small RNA functions in carbon metabolism and virulence of enteric

pathogens Frontiers in Cellular and Infection Microbiology 4:91.

Förstner KU., Vogel J., Sharma CM. (2014) REDemption-a tool for the computational analysis of deep-

sequencing-based transcriptome data Bioinformatics 30:3421-3413.

Vogel J., Gottesman S., Belasco JG., Narberhaus F. (2014) Meeting report: Regulating with RNA in

Bacteria 2013 RNA Biology 11:403-412.

Podkaminski D., Bouvier M., Vogel J. (2014) Identification and characterization of small noncoding

RNAs in bacteria Handbook of RNA Biochemistry Wiley-VCH.

Papenfort K., Sun Y., Miyakoshi M., Vanderpool CK., Vogel J. (2013) Small RNA-mediated activation of

sugar phosphatase mRNA regulates glucose homeostasis Cell 153:426-437.

Fröhlich KS., Papenfort K., Fekete A., Vogel J. (2013) A small RNA activates CFA synthase by isoform-

specific mRNA stabilization EMBO Journal 32:2963-2979.

Heidrich N., Vogel J. (2013) Same same but different: new structural insight into CRISPR-Cas

complexes Molecular Cell 52:4-7.

Zhang Y., Heidrich N., Ampattu BJ., Gunderson CW., Seifert HS., Schoen C., Vogel J., Sontheimer EJ.

(2013) Processing-Independent CRISPR RNAs Limit Natural Transformation in Neisseria meningitides

Molecular Cell 50:488-503.

Holmqvist E., Vogel J. (2013) A small RNA serving both the Hfq and CsrA regulons Genes &

Development 27:1073-1078.

Göpel Y., Papenfort K., Reichenbach B., Vogel J., Görke B. (2013) Targeted decay of a regulatory small

RNA by an adaptor protein for RNase E and counteraction by an anti-adaptor RNA Genes &

Development 27:552-564.

Wright PR., Richter AS., Papenfort K., Mann M., Vogel J., Hess WR., Backofen R., Georg J. (2013)

Comparative genomics boosts target prediction for bacterial small RNAs PNAS 110:E3487-3496.

Heidrich N., Vogel J. (2013) CRISPRs extending their reach: Prokaryotic RNAi protein Cas9 recruited

for gene regulation EMBO Journal 32:1802-1804.

Gutierrez A., Laureti L., Crussard S., Abida H., Rodríguez Rojas A., Blázquez J., Baharoglu Z., Mazel D.,

Darfeuille F., Vogel J., Matic I. (2013) β-lactam antibiotics promote bacterial mutagenesis via RpoS-

mediated reduction in replication fidelity Nature Communications 4:1610.

99

Schulte LN., Westermann AJ., Vogel J. (2013) Differential activation and functional specialisation of

miR-146 and miR-155 in innate immune sensing Nucleic Acids Research 41(1):542-53.

Vogel J., Bassler BL. (2013) Bacterial Regulatory Mechanisms: The gene and beyond Current Opinion

in Microbiology 16:109-11.

Caldelari I., Chao Y., Romby P., Vogel J. (2013) RNA-mediated regulation in pathogenic bacteria Cold

Spring Harb Perspect Med 3.

Papenfort K., Corcoran CP., Gupta SK., Miyakoshi M., Heidrich N., Chao Y., Fröhlich KS., Sharma CM.,

Ziebuhr W., Böhm A., Vogel J. (2013) Regulatory Mechanisms of Special Significance: The role of

sRNAs in Virulence Regulation in: Regulation of Bacterial Virulence ASM Press pp. 493-527.

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Wagner-Döbler, Irene

Ammermann J., Schmidt T., *Donner J., *Reck M., Dalton M., Stumpp N., Stiesch M., *Wagner-Döbler I., Kirschning A. (2017) The Carolactam strategy is ineffective: Synthesis and biological evaluation of Carolactam Organic and Biomolecular Chemistry 15: 8553 - 8558. Beyersmann P.G., *Tomasch J., Son K., Stocker R., Göker M., *Wagner-Döbler I., Simon M., Brinkhoff T. (2017) Dual function of tropodithietic acid as antibiotic and signaling molecule in global gene regulation of the probiotic bacterium Phaeobacter inhibens Scientific Reports 7: 730. Bill N., *Tomasch J., Riemer A., Müller K., Kleist S., Schmidt-Hohagen K., *Wagner-Döbler I., Schomburg D. (2017) Fixation of CO2 using the ethylmalonyl-CoA pathway in the photoheterotrophic marine bacterium Dinoroseobacter shibae Environmental Microbiology 19: 2645 - 2660. Bruns H, *Herrmann J, *Müller R, *Wang H, *Wagner Döbler I, Schulz S. (2017) Oxygenated N-Acyl Alanine Methyl Esters (NAMEs) from the Marine Bacterium Roseovarius tolerans EL-164 Journal of Natural Products J Nat Prod. 2017 Dec 20. doi: 10.1021/acs.jnatprod.7b00757. *Deng Z.-L., Szafranski S.P., *Jarek M., *Bhuju S., *Wagner-Döbler I. (2017) Dysbiosis in chronic periodontitis: Key microbial players and interactions with the human host Scientific Reports 7: 3703. Donner J, Bunk B, Schober I, Spröer C, Bergmann S, Jarek M, Overmann J, Wagner-Döbler I. (2017) Complete Genome Sequences of Three Multidrug-Resistant Clinical Isolates of Streptococcus pneumoniae Serotype 19A with Different Susceptibilities to the Myxobacterial Metabolite Carolacton Genome Announcements 5: pii: e01641-16. Donner J, Reck M, Bunk B, Jarek M, App CB, Meier-Kolthoff JP, Overmann J, Müller R, Kirschning A, Wagner-Döbler I. (2017) The Biofilm Inhibitor Carolacton Enters Gram-Negative Cells: Studies Using a TolC-Deficient Strain of Escherichia coli mSphere 2: pii: e00375-17. *Fu C., *Sikandar A., *Donner J., *Zaburannyi N., *Herrmann J., *Reck M., *Wagner-Döbler I., *Koehnke J., *Müller R. (2017) The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD Nature Communications 8: 1529. Gottschick C, Deng ZL, Vital M, Masur C, Abels C, Pieper DH, Rohde M, Mendling W, Wagner-Döbler I. (2017) Treatment of biofilms in bacterial vaginosis by an amphoteric tenside pessary-clinical study and microbiota analysis Microbiome 5: 119. Gottschick C, Deng ZL, Vital M, Masur C, Abels C, Pieper DH, Wagner-Döbler I. (2017) The urinary microbiota of men and women and its changes in women during bacterial vaginosis and antibiotic treatment Microbiome 5: 99. Petersen J., *Wagner-Döbler I. (2017) Plasmid transfer in the ocean - A case study from the Roseobacter group Frontiers in Microbiology 8: 1350. Simon M, Scheuner C, Meier-Kolthoff JP, Brinkhoff T, Wagner-Döbler I, Ulbrich M, Klenk HP, Schomburg D, Petersen J, Göker M. (2017) Phylogenomics of Rhodobacteraceae reveals evolutionary adaptation to marine and non-marine habitats ISME Journal 11: 1483 - 1499. *Szafranski SP, *Deng ZL, *Tomasch J, *Jarek M, *Bhuju S, *Rohde M, *Sztajer H, *Wagner-Döbler I. (2017) Quorum sensing of Streptococcus mutans is activated by Aggregatibacter actinomycetemcomitans and by the periodontal microbiome BMC Genomics 18: 238.

101

Cabarcas-Montalvo M., Maldonado-Rojas W., Montes-Grajales D., Bertel-Sevilla A., *Wagner-Döbler I., *Sztajer H., *Reck M., Flechas-Alarcon M., Ocazionez R., Olivero-Verbel J. (2016) Discovery of antiviral molecules for dengue: In silico search and biological evaluation European Journal of Medicinal Chemistry 110: 87 - 97. *Donner J., *Reck M., Bergmann S., Kirschning A., *Müller R., *Wagner-Döbler I. (2016) The biofilm inhibitor Carolacton inhibits planktonic growth of virulent Pneumococci via a conserved target Scientific Reports 6: 29677. *Gottschick C., *Szafranski S.P., *Kunze B., *Sztajer H., Masur C., Abels C., *Wagner-Döbler I. (2016) Screening of compounds against Gardnerella vaginalis biofilms PLoS ONE 11: e0154086. *Milici M., *Deng Z.L., *Tomasch J., Decelle J., *Wos-Oxley M.L., *Wang H., *Jáuregui R., *Plumeier I., Giebel H.A., Badewien T.H., Wurst M., *Pieper D.H., Simon M., *Wagner-Döbler I. (2016) Co-occurrence analysis of microbial taxa in the Atlantic ocean reveals high connectivity in the free-living bacterioplankton Frontiers in Microbiology 7: 649. *Milici M., *Tomasch J., *Wos-Oxley M.L., *Wang H., *Jáuregui R., *Camarinha-Silva A., *Deng Z.-L., *Plumeier I., Giebel H.-A., Wurst M., *Pieper D.H., Simon M., *Wagner-Döbler I. (2016) Low diversity of planktonic bacteria in the tropical ocean Scientific Reports 6: 1 - 9. *Milici M., *Tomasch J., *Wos-Oxley M.L., Decelle J., *Jáuregui R., *Wang H., *Deng Z.-L., *Plumeier I., Giebel H.-A., Badewien T.H., Wurst M., Pieper D.H., Simon M., *Wagner-Döbler I. (2016) Bacterioplankton biogeography of the Atlantic ocean: A case study of the distance-decay relationship Frontiers in Microbiology 7: 590. *Patzelt D., Michael V., Päuker O., Ebert M., Tielen P., Jahn D., *Tomasch J., Petersen J., *Wagner-Döbler I. (2016) Gene flow across genus barriers - Conjugation of Dinoroseobacter shibae's 191-kb killer plasmid into Phaeobacter inhibens and AHL-mediated expression of type IV secretion systems Frontiers in Microbiology 7: 742. *Reck M., *Wagner-Döbler I. (2016) Carolacton treatment causes delocalization of the cell division proteins PknB and DivIVa in Streptococcus mutans in vivo Frontiers in Microbiology 11: 684. *Wagner-Döbler I. (2016) Biofilm transplantation in the deep sea Molecular Ecology 25: 1905 - 1907. Gomez-Consarnau L., Gonzalez J.M., Riedel T., Jaenicke S., *Wagner-Döbler I., Sanudo-Wilhelmy S.A., Fuhrman J.A. (2015) Proteorhodopsin light-enhanced growth linked to vitamin-B1 acquisition in marine Flavobacteria ISME Journal 10: 1102 - 1112. Klingner A., Bartsch A., Dogs M., *Wagner-Dobler I., Jahn D., Simon M., Brinkhoff T., Becker J., Wittmann C. (2015) Large-scale 13C flux profiling reveals conservation of the Entner-Doudoroff pathway as a glycolytic strategy among marine bacteria that use glucose Applied and Environmental Microbiology 81: 2408 - 2422. *Reck M., *Tomasch J., *Deng Z., *Jarek M., *Husemann P., *Wagner-Dobler I. (2015) Stool metatranscriptomics: A technical guideline for mRNA stabilisation and isolation BMC Genomics 16: 194. *Reck M., *Tomasch J., *Wagner-Dobler I. (2015) The Alternative Sigma Factor SigX Controls Bacteriocin Synthesis and Competence, the Two Quorum Sensing Regulated Traits in Streptococcus mutans PLoS Genetics 11: e1005353.

102

Soora M., *Tomasch J., *Wang H., Michael V., Petersen J., Engelen B., *Wagner-Dobler I., Cypionka H. (2015) Oxidative stress and starvation in Dinoroseobacter shibae: The role of extrachromosomal elements Frontiers in Microbiology 6: 233. Stumpp N., *Premnath P., Schmidt T., Ammermann J., Drager G., *Reck M., *Jansen R., Stiesch M., *Wagner-Dobler I., Kirschning A. (2015) Synthesis of new Carolacton derivatives and their activity against biofilms of oral bacteria Organic and Biomolecular Chemistry 13: 5765 - 5774. *Szafranski S.P., *Wos-Oxley M.L., *Vilchez-Vargas R., *Jauregui R., *Plumeier I., *Klawonn F., *Tomasch J., Meisinger C., Kuhnisch J., *Sztajer H., *Pieper D.H., *Wagner-Dobler I. (2015) High-resolution taxonomic profiling of the subgingival microbiome for biomarker discovery and periodontitis diagnosis Applied and Environmental Microbiology 81: 1047 - 1058. *Szafranski, S.P., *Deng Z.L., *Tomasch J., *Jarek M., *Bhuju S., Meisinger C., Kühnisch J., *Sztajer H., *Wagner-Döbler I. (2015) Functional biomarkers for chronic periodontitis and insights into the roles of Prevotella nigrescens and Fusobacterium nucleatum; a metatranscriptome analysis npj Biofilms and Microbiomes 1: 15017. Voget S., Bruns H., *Wagner-Döbler I., Schulz S., Daniel R. (2015) Draft Genome Sequence of Roseovarius tolerans EL-164, a Producer of N-Acylated Alanine Methyl Esters and N-Acylhomoserine Lactones Genome Announcements 3: e01096-15. *Wang H., *Tomasch J., Michael V., *Bhuju S., *Jarek M., Petersen J., *Wagner-Döbler I. (2015) Identification of genetic modules mediating the Jekyll and Hyde interaction of Dinoroseobacter shibae with the dinoflagellate Prorocentrum minimum Frontiers in Microbiology 6: 1262. Ziesche L., Bruns H., Dogs M., Wolter L., Mann F., *Wagner-Dobler I., Brinkhoff T., Schulz S. (2015) Homoserine Lactones, Methyl Oligohydroxybutyrates, and Other Extracellular Metabolites of Macroalgae-Associated Bacteria of the Roseobacter Clade: Identification and Functions ChemBioChem 16: 2094 - 2107. Conrads G., de Soet J..J, Song L., Henne K., *Sztajer H., *Wagner-Döbler I., Zeng A.P. (2014) Comparing the cariogenic species Streptococcus sobrinus and S. mutans on whole genome level Journal of Oral Microbiology 6: 26189. Sudhakar P., *Reck M., Wang W., He F.Q., *Wagner-Dobler I.W., Zeng A.-P. (2014) Construction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor Carolacton BMC Genomics 15: 362. *Sztajer H., *Szafranski S.P., *Tomasch J., *Reck M., *Nimtz M., *Rohde M., *Wagner-Dobler I. (2014) Cross-feeding and interkingdom communication in dual-species biofilms of Streptococcus mutans and Candida albicans ISME Journal 8: 2256 - 2271. *Wang H., *Tomasch J., *Jarek M., *Wagner-Dobler I. (2014) A dual-species co-cultivation system to study the interactions between Roseobacters and dinoflagellates Frontiers in Microbiology 5: Article 311. *Wang H., Ziesche L., Frank O., Michael V., *Martin M., Petersen J., Schulz S., *Wagner-Dobler I., *Tomasch J. (2014) The CtrA phosphorelay integrates differentiation and communication in the marine alphaproteobacterium Dinoroseobacter shibae BMC Genomics 15: 130.

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Apel C., Barg A., Rheinberg A., Conrads G., *Wagner-Dobler I. (2013) Dental composite materials containing Carolacton inhibit biofilm growth of Streptococcus mutans Dental Materials 29: 1188 - 1199. Brock N.L., Citron C.A., Zell C., Berger M., *Wagner-Dobler I., Petersen J., Brinkhoff T., Simon M., Dickschat J.S. (2013) Isotopically labeled sulfur compounds and synthetic selenium and tellurium analogues to study sulfur metabolism in marine bacteria Beilstein Journal of Organic Chemistry 9: 942 - 950. Bruns H., Thiel V., Voget S., *Patzelt D., Daniel R., *Wagner-Dobler I., Schulz S. (2013) N-acylated alanine methyl esters (NAMEs) from Roseovarius tolerans, structural analogs of quorum-sensing autoinducers, N-acylhomoserine lactones Chemistry and Biodiversity 10: 1559 - 1573. Fiebig A., Pradella S., Petersen J., Michael V., Pauker O., *Rohde M., Göker M., Klenk H.-P., *Wagner-Dobler I. (2013) Genome of the marine alphaproteobacterium Hoeflea phototrophica type strain (DFL-43T) Standards in Genomic Sciences 7: 440 - 448. Fiebig A., Pradella S., Petersen J., Päuker O., Michael V., *Lünsdorf H., Göker M., Klenk H.-P. , *Wagner-Döbler I (2013) Genome of the R-body producing marine alphaproteobacterium Labrenzia alexandrii type strain (DFL-11T) Standards in Genomic Sciences 7: 413 - 426. Neumann A., *Patzelt D., *Wagner-Dobler I., Schulz S. (2013) Identification of new N-acylhomoserine lactone signalling compounds of Dinoroseobacter shibae DFL-12T by overexpression of luxI genes ChemBioChem 14: 2355 - 2361. *Patzelt D., *Wang H., Buchholz I., *Rohde M., Grobe L., Pradella S., Neumann A., Schulz S., Heyber S., Munch K., Munch R., Jahn D., *Wagner-Dobler I., *Tomasch J. (2013) You are what you talk: Quorum sensing induces individual morphologies and cell division modes in Dinoroseobacter shibae ISME Journal 7: 2274 - 2286. *Riedel T., *Rohlfs M., *Buchholz I., *Wagner-Dobler I., *Reck M. (2013) Complete sequence of the suicide vector pJP5603 Plasmid 69: 104 - 107. *Riedel T., Gomez-Consarnau L., *Tomasch J., *Martin M., *Jarek M., Gonzalez J.M., Spring S., *Rohlfs M., Brinkhoff T., Cypionka H., Göker M., Fiebig A., Klein J., Goesmann A., Fuhrman J.A., *Wagner-Dobler I. (2013) Genomics and Physiology of a Marine Flavobacterium Encoding a Proteorhodopsin and a Xanthorhodopsin-Like Protein PLoS ONE 8: e57487. Song L., Wang W., Conrads G., Rheinberg A., *Sztajer H., *Reck M., *Wagner-Dobler I., Zeng A.-P. (2013) Genetic variability of mutans streptococci revealed by wide whole-genome sequencing BMC Genomics 14: 430.

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Topic 2

Brinkmann, Melanie

Babdor J, Descamps D, Adiko AC, Tohmé M, Maschalidi S, Evnouchidou I, Vasconcellos LR, De Luca M,

Mauvais FX, Garfa-Traore M, *Brinkmann MM, Chignard M, Manoury B, Saveanu L. (2017) IRAP(+)

endosomes restrict TLR9 activation and signaling Nature Immunology 18: 509 - 518.

*Chan B., *Gonçalves Magalhães V., Lemmermann N.A.W., Juranic Lisnic V., *Stempel M., *Bussey

K.A., *Reimer E., Podlech J., *Lienenklaus S., Reddehase M.J., Jonjic S., *Brinkmann M.M. (2017) The

murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern

recognition receptors by targeting NF-κB mediated transcription PLoS Pathogens 13: e1006382.

Thurm C., Poltorak M.P., *Reimer E., *Brinkmann M.M., Leichert L., *Schraven B., Simeoni L. (2017) A

highly conserved redox-active Mx(2)CWx(6)R motif regulates Zap70 stability and activity Oncotarget

8: 30805 - 30816.

*Andzinski L., *Spanier J., *Kasnitz N., *Kröger A., Jin L., *Brinkmann M.M., *Kalinke U., *Weiss S.,

*Jablonska J., *Lienenklaus S. (2016) Growing tumors induce a local STING dependent Type I IFN

response in dendritic cells International Journal of Cancer 139: 1350 - 1357.

Nocera D.A., Roselli E., Araya P., Nuñez N.G., *Lienenklaus S., *Jablonska J., *Weiss S., Gatti G.,

*Brinkmann M.M., *Kröger A., Morón G., Maccioni M. (2016) In vivo visualizing the IFN-ß response

required for tumor growth control in a therapeutic model of polyadenylic-polyuridylic acid

administration Journal of Immunology 196: 2860 - 2869.

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Vaccine 35: 6949 - 6956. *Lirussi D., *Ebensen T., *Schulze K., *Trittel S., *Duran V., Liebich I., *Kalinke U., *Guzmán C.A. (2017) Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway EBioMedicine 22: 100 - 111. *Matos M.N., Cazorla S.I., *Schulze K., *Ebensen T., *Guzmán C.A., Malchiodi E.L. (2017) Immunization with Tc52 or its amino terminal domain adjuvanted with c-di-AMP induces Th17+Th1 specific immune responses and confers protection against Trypanosoma cruzi PLoS Neglected Tropical Diseases 11: e0005300. Mazzuca P., Marsico S., *Schulze K., Mitola S., *Pils M.C., Giagulli C., *Guzmán C.A., Caruso A., Caccuri F. (2017) Role of autophagy in HIV-1 matrix protein p17-driven lymphangiogenesis Journal of Virology 91: e00801-17. *Riese P., *Guzmán C.A. (2017) Roads to advanced vaccines: influenza case study Microbial Biotechnology 10: 1036 - 1040. *Rueckert C., *Rand U., *Roy U., *Kasmapour B., *Strowig T., *Guzmán C.A. (2017) Cyclic dinucleotides modulate induced type i IFN responses in innate immune cells by degradation of STING FASEB Journal 31: 3107 - 3115. Sanchez Alberti A,, Bivona A.E., Cerny N., *Schulze K., *Weißmann S., *Ebensen T., Morales C., Padilla A.M., Cazorla S.I., Tarleton R.L., *Guzmán C.A., Malchiodi E.L. (2017) Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against Trypanosoma cruzi infection NPJ Vaccines 2: 9. *Schulze K., *Ebensen T., Babiuk L.A., Gerdts V., *Guzmán C.A. (2017) Intranasal vaccination with an adjuvanted polyphosphazenes nanoparticle-based vaccine formulation stimulates protective immune responses in mice Nanomedicine: Nanotechnology, Biology, and Medicine 13: 2169 - 2178. *Schulze K., *Ebensen T., Chandrudu S., Skwarczynski M., Toth I., Olive C., *Guzmán C.A. (2017) Bivalent mucosal peptide vaccines administered using the LCP carrier system stimulate protective immune responses against Streptococcus pyogenes infection Nanomedicine: Nanotechnology, Biology, and Medicine 13: 2463 - 2474. *Volckmar J., *Gereke M., *Ebensen T., *Riese P., Philipsen L., *Lienenklaus S., Wohlleber D., *Klopfleisch R., *Stegemann-Koniszewski S., *Müller A.J., Gruber A.D., Knolle P., *Guzmán C.A., Bruder D. (2017) Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver Scientific Reports 7: 43985. *Ziegler A., *Soldner C., *Lienenklaus S., *Spanier J., *Trittel S., *Riese P., Kramps T., *Weiss S., Heidenreich R., Jasny E., *Guzmán C.A., Kallen K.-J., Fotin-Mleczek M., *Kalinke U. (2017) A new RNA-based adjuvant enhances virus-specific vaccine responses by locally triggering TLR- and RLH-dependent effects Journal of Immunology 198: 1595 - 1605. Börger A.-K., Eicke D., Wolf C., Gras C., Aufderbeck S., *Schulze K., Engels L., Eiz-Vesper B., Schambach A., *Guzmán C., Lachmann N., Moritz T., Martin U., De Rainer C., Figueiredo C. (2016) Generation of hla-universal ipsc-derived megakaryocytes and platelets for survival under refractoriness conditions Molecular Medicine 22: 274 - 285. Démoulins T., Milona P., Englezou P.C., *Ebensen T., *Schulze K., Suter R., Pichon C., Midoux P.,

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*Guzmán C.A., Ruggli N., McCullough K.C. (2016) Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines Nanomedicine: Nanotechnology, Biology, and Medicine 12: 711 - 722. *Perin P.M., *Haid S., *Brown R.J., *Doerrbecker J., *Schulze K., Zeilinger C., von Schaewen M., Heller B., Vercauteren K., *Luxenburger E., Baktash Y.M., Vondran F.W., Speerstra S., Awadh A., Mukhtarov F., Schang L.M., Kirschning A., *Müller R., *Guzmán (2016) Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1 Hepatology 63: 49 - 62. *Schulze K., *Ebensen T., *Riese P., *Prochnow B., *Lehr C.-M., *Guzmán C.A. (2016) New horizons in the development of novel needle-free immunization strategies to increase vaccination efficacy Current Topics in Microbiology and Immunology 398: 207 - 234. Tomic A., Varanasi P.R., Golemac M., Malic S., *Riese P., Borst E.M., Mischak-Weissinger E., *Guzmán C.A., Krmpotic A., Jonjic S., Messerle M. (2016) Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand PLoS Pathogens 12: e1006015. *Vázquez C.L., Rodgers A., Herbst S., Coade S., *Gronow A., *Guzmán C.A., Wilson M.S., Kanzaki M., Nykjaer A., Gutierrez M.G. (2016) The proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages Scientific Reports 6: 29332. *Yasar H., *Gordon S., *Loretz B., *Schulze K., *Guzmán C.A., *Lehr C.-M. (2016) Follicular Drug Delivery: a Root to Success The Medicine Maker September. *Akmatov M.K., Kimani-Murage E., *Pessler F., *Guzmán C.A., *Krause G., Kreienbrock L., *Mikolajczyk R.T. (2015) Evaluation of invalid vaccine doses in 31 countries of the WHO African Region Vaccine 33: 892 - 901. *Boianelli A., *Nguyen,V.K., *Ebensen T., *Schulze K., *Wilk E., *Sharma N., *Stegemann-Koniszewski S., *Bruder D., Toapanta F.R., *Guzmán C.A., *Meyer-Hermann M., *Hernandez-Vargas E.A. (2015) Modeling influenza virus infection: A roadmap for influenza research Viruses 7: 5274 - 5304. Cazorla S.I., Matos M.N., Cerny N., Ramirez C., Alberti A.S., Bivona A.E., Morales .C, *Guzmán C.A., Malchiodi E.L. (2015) Oral multicomponent DNA vaccine delivered by attenuated Salmonella elicited immunoprotection against American trypanosomiasis Journal of Infectious Diseases 211: 698 - 707. Daenthanasanmak A., Salguero G., Sundarasetty B.S., Waskow C., Cosgun K.N., *Guzmán C.A., *Riese P., Gerasch L., Schneider A., Ingendoh A., Messerle M., Gabaev I., Woelk B., Ruggiero E., Schmidt M., von Kalle C., Figueiredo C., Eiz-Vesper B., von Kaisenberg C., Ganser A., Stripecke R. (2015) Engineered dendritic cells from cord blood and adult blood accelerate effector T cell immune reconstitution against HCMV Molecular Therapy — Methods & Clinical Development 1: 14060. Geels M.J., Thogersen R.L., *Guzmán C.A., Ho M.M., Verreck F., Collin N., Robertson J.S., McConkey S.J., Kaufmann S.H.E., Leroy O. (2015) TRANSVAC research infrastructure - Results and lessons learned from the European network of vaccine research and development Vaccine 33: 5481 - 5487. *Gordon S., Daneshian M., Bouwstra J., Caloni F., Constant S., Davies D.E., Dandekar G., *Guzmán C.A., Fabian E., Haltner E., Hartung T., Hasiwa N., Hayden P., Kandarova H., Khare S., Krug H.F., Kneuer C., Leist M., Lian G., Marx U., Metzger M., Ott K, P (2015) Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology ALTEX

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32: 327 - 378. *Kramer R., Sauer-Heilborn A., Welte T., *Guzmán C.A., *Abraham W.-R., *Höfle M.G. (2015) Cohort study of airway mycobiome in adult cystic fibrosis patients: Differences in community structure between fungi and bacteria reveal predominance of transient fungal elements Journal of Clinical Microbiology 53: 2900 - 2907. *Kramer R., Sauer-Heilborn A., Welte T., *Guzmán C.A., *Höfle M.G., *Abraham W.-R. (2015) A rapid method for breath analysis in cystic fibrosis patients European Journal of Clinical Microbiology and Infectious Diseases 34: 745 - 751. *Kramer R., Sauer-Heilborn A., Welte T., *Jauregui R., *Brettar I., *Guzmán C.A., *Höfle M.G. (2015) High individuality of respiratory bacterial communities in a large cohort of adult cystic fibrosis patients under continuous antibiotic treatment PLoS ONE 10: e0117436. Major D., Chichester J.A., Pathirana R.D., Guilfoyle K., Shoji Y., *Guzmán C.A., Yusibov V., Cox R.J. (2015) Intranasal vaccination with a plant-derived H5 HA vaccine protects mice and ferrets against highly pathogenic avian influenza virus challenge Human Vaccines and Immunotherapeutics 11: 1235 - 1243. Mittal A., *Schulze K., *Ebensen T., *Weissmann S., *Hansen S., *Guzmán C.A., *Lehr C.-M. (2015) Inverse micellar sugar glass (IMSG) nanoparticles for transfollicular vaccination Journal of Controlled Release 206: 140 - 152. Mittal A., *Schulze K., *Ebensen T., *Weissmann S., *Hansen S., *Lehr C.M., *Guzmán C.A. (2015) Efficient nanoparticle-mediated needle-free transcutaneous vaccination via hair follicles requires adjuvantation Nanomedicine: Nanotechnology, Biology, and Medicine 11: 147 - 154. *Riese P., *Trittel S., *May T., *Cicin-Sain L., Chambers B.J., *Guzmán C.A. (2015) Activated NKT cells

imprint NK-cell differentiation, functionality and education European Journal of Immunology 45:

1794 - 1807.

*Riese P., *Trittel S., *Schulze K., *Guzmán C.A. (2015) Rodents as pre-clinical models for predicting

vaccine performance in humans Expert Review of Vaccines 14: 1213 - 1225.

*Stern C., *Kasnitz N., *Kocijancic D., *Trittel S., *Riese P., *Guzmán C.A., *Leschner S., *Weiss S.

(2015) Induction of CD4+ and CD8+ anti-tumor effector T cell responses by bacteria mediated tumor

therapy International Journal of Cancer 137: 2019 - 2028.

*Becker P.D., *Nörder M., *Weissmann S., Ljapoci R., Erfle V., Drexler I., *Guzmán C.A. (2014) Gene

expression driven by a strong viral promoter in MVA increases vaccination efficiency by enhancing

antibody responses and unmasking CD8+ T cell Epitopes Vaccines 2: 581 - 600.

Caccuri F., Giagulli C., *Reichelt J., Martorelli D., Marsico S., Bugatti A., Barone I., Rusnati M.,

*Guzmán C.A., Dolcetti R., Caruso A. (2014) Simian immunodeficiency virus and human

immunodeficiency virus type 1 matrix proteins specify different capabilities to modulate b cell

growth Journal of Virology 88: 5706 - 5717.

Caccuri F., Rueckert C., Giagulli C., *Schulze K., Basta D., Zicari S., Marsico S., Cervi E., Fiorentini S.,

Slevin M., *Guzmán C.A., Caruso A. (2014) HIV-1 matrix protein p17 promotes lymphangiogenesis

and activates the endothelin-1/endothelin B receptor axis Arteriosclerosis, Thrombosis and Vascular

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Biology 34: 846 - 856.

Dutruel C., Thole J., Geels M., Mollenkopf H.-J., Ottenhoff T., *Guzmán C.A., Fletcher H.A., Leroy O.,

Kaufmann S.H.E. (2014) TRANSVAC workshop on standardisation and harmonisation of analytical

platforms for HIV, TB and malaria vaccines: 'How can big data help?' Vaccine 32: 4365 - 4368.

*Hernandez-Vargas E.A., *Wilk E., Canini L., Toapanta F.R., *Binder S.C., *Uvarovskii A., Ross T.M.,

*Guzmán C.A., Perelson A.S., *Meyer-Hermann M. (2014) Effects of aging on influenza virus infection

dynamics Journal of Virology 88: 4123 - 4131.

Matos M.N., Cazorla S.I., Bivona A.E., Morales C., *Guzmán C.A., Malchiodi E.L. (2014) Tc52 amino-

terminal-domain DNA carried by attenuated Salmonella enterica serovar typhimurium induces

protection against a trypanosoma cruzi lethal challenge Infection and Immunity 82: 4265 - 4275.

Matos M.N., Cazorla S.I., Bivona A.E., Morales C., *Guzmán C.A., Malchiodi E.L. (2014) Tc52 amino-

terminal-domain DNA carried by attenuated Salmonella enterica serovar typhimurium induces

protection against a trypanosoma cruzi lethal challenge Infection and Immunity 82: 4265 - 4275.

Neuhaus V., Chichester J.A., *Ebensen T., Schwarz K., Hartman C.E., Shoji Y., *Guzmán C.A., Yusibov

V., Sewald K., Braun A. (2014) A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced

antigen-specific local mucosal and systemic immune responses after administration into the lung

Vaccine 32: 3216 - 3222.

Pandey S.P., Chandel H.S., Srivastava S., Selvaraj S., Jha M.K., Shukla D., *Ebensen T., *Guzmán C.A.,

Saha B. (2014) Pegylated bisacycloxypropylcysteine, a diacylated lipopeptide ligand of TLR6, plays a

host-protective role against experimental leishmania major infection Journal of Immunology 193:

3632 - 3643.

Retamal-Diaz A., Riquelme-Neira R., Saez D., Rivera A., Fernandez P., *Cabrera A., *Guzmán C.A.,

Onate A. (2014) Use of S-[2,3-bispalmitoyiloxy-(2R)-propyl]-R-cysteinyl-amido-monomethoxy

polyethylene glycol as an adjuvant improved protective immunity associated with a DNA vaccine

encoding Cu,Zn superoxide dismutase of Brucella abortus in mice Clinical and Vaccine Immunology

21: 1474 – 1480.

Neuhaus V., Chichester J.A., *Ebensen T., Schwarz K., Hartman C.E., Shoji Y., *Guzmán C.A., Yusibov

V., Sewald K., Braun A. (2014) A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced

antigen-specific local mucosal and systemic immune responses after administration into the lung

Vaccine 32: 3216 - 3222.

Pandey S.P., Chandel H.S., Srivastava S., Selvaraj S., Jha M.K., Shukla D., *Ebensen T., *Guzmán C.A.,

Saha B. (2014) Pegylated bisacycloxypropylcysteine, a diacylated lipopeptide ligand of TLR6, plays a

host-protective role against experimental leishmania major infection Journal of Immunology 193:

3632 - 3643.

Retamal-Diaz A., Riquelme-Neira R., Saez D., Rivera A., Fernandez P., *Cabrera A., *Guzmán C.A.,

Onate A. (2014) Use of S-[2,3-bispalmitoyiloxy-(2R)-propyl]-R-cysteinyl-amido-monomethoxy

polyethylene glycol as an adjuvant improved protective immunity associated with a DNA vaccine

encoding Cu,Zn superoxide dismutase of Brucella abortus in mice Clinical and Vaccine Immunology

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21: 1474 - 1480.

*Riese P, *Sakthivel P., *Trittel S., *Guzmán C.A. (2014) Intranasal formulations: Promising strategy

to deliver vaccines Expert Opinion on Drug Delivery 11: 1619 - 1634.

Salguero G., Daenthanasanmak A., Munz C., Raykova A., *Guzmán C.A., *Riese P., Figueiredo C.,

Langer F., Schneider A., Macke L., Sundarasetty B.S., Witte T., Ganser A., Stripecke R. (2014) Dendritic

cell-mediated immune humanization of mice: Implications for allogeneic and xenogeneic stem cell

transplantation Journal of Immunology 192: 4636 - 4647.

*Sanchez M.V., *Ebensen T., *Schulze K., Cargnelutti D., Blazejewska P., Scodeller E.A., *Guzmán C.A.

(2014) Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and

cellular immune responses and provides protection against virus challenge PLoS ONE 9: e104824.

*Skrnjug I., *Guzmán C.A., *Ruecker C. (2014) Cyclic GMP-AMP displays mucosal adjuvant activity in

mice PLoS ONE 9: e110150.

*Skrnjug I., *Rueckert C., *Libanova R., *Lienenklaus S., *Weiss S., *Guzmán C.A. (2014) The mucosal

adjuvant cyclic di-AMP exerts immune stimulatory effects on dendritic cells and macrophages PLoS

ONE 9: e95728.

Gismondi M.I., Diaz Carrasco J.M., Valva P., *Becker P.D., *Guzmán C.A., Campos R.H., Preciado M.V.

(2013) Dynamic changes in viral population structure and compartmentalization during chronic

hepatitis C virus infection in children Virology 447: 187 - 196.

Gras C., *Schulze K., Goudeva L., *Guzmán C.A., Blasczyk R., Figueiredo C. (2013) HLA-universal

platelet transfusions prevent platelet refractoriness in a mouse model Human Gene Therapy 24:

1018 - 1028.

*Gurramkonda C., Zahid M., Nemani S.K., *Adnan A., Gudi S.K., Khanna N., *Ebensen T., *Lunsdorf

H., *Guzmán C.A., *Rinas U. (2013) Purification of hepatitis B surface antigen virus-like particles from

recombinant Pichia pastoris and in vivo analysis of their immunogenic properties Journal of

Chromatography B 940: 104 - 111.

*Riese P., *Schulze K., *Ebensen T., *Prochnow B., *Guzmán .CA. (2013) Vaccine adjuvants: key tools

for innovative vaccine design. Current Topics in Medicinal Chemistry 13: 2562 - 2580.

Mittal A., Raber A.S., Schaefer U.F., *Weissmann S., *Ebensen T., *Schulze K., *Guzmán C.A.,

*Hansen S., *Lehr C. (2013) Transfollicular delivery of antigen using nanocarriers for non-invasive

transcutaneous immunization Controlled Release Society (CRS) Letters 30: 16.

Mittal A., Raber A.S., Schaefer U.F., *Weissmann S., *Ebensen T., *Schulze K., *Guzmán C.A., *Lehr

C.-M., *Hansen S. (2013) Non-invasive delivery of nanoparticles to hair follicles: A perspective for

transcutaneous immunization Vaccine 31: 3442 - 3451.

Svindland S.C., Pedersen G.K., Pathirana R.D., Bredholt G., Nostbakken J.K., Jul-Larsen A., *Guzmán

C.A., Montomoli E., Lapini G., Piccirella S., Jabbal-Gill I., Hinchcliffe M., Cox R.J. (2013) A study of

Chitosan and c-di-GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine Influenza and

other Respiratory Viruses 7: 1181 - 1193.

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*Yevsa T., *Ebensen T., *Fuchs B., *Zygmunt B., *Libanova R., Gross R., *Schulze K., *Guzmán C.A.

(2013) Development and characterization of attenuated metabolic mutants of Bordetella

bronchiseptica for applications in vaccinology Environmental Microbiology 15: 64 - 76.

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Hühn, Jochen

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of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans"


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Medina, Eva

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Staphylococcus aureus strains PLoS ONE 10: e0145861. *Horst S.A., *Itzek A., Klos A., Beineke A., *Medina E. (2015) Differential Contributions of the Complement Anaphylotoxin Receptors C5aR1 and C5aR2 to the Early Innate Immune Response against Staphylococcus aureus Infection Pathogens 4: 722 - 738. *Loof T.G., *Goldmann O., Naudin C., Morgelin M., *Neumann Y., *Pils M.C., Foster S.J., *Medina E., Herwald H. (2015) Staphylococcus aureus-induced clotting of plasma is an immune evasion mechanism for persistence within the fibrin network Microbiology (United Kingdom) 161: 621 - 627. *Tebartz C., *Horst S.A., *Sparwasser T., *Hühn J., Beineke A., Peters G., *Medina E. (2015) A major role for myeloid-derived suppressor cells and a minor role for regulatory T cells in immunosuppression during Staphylococcus aureus infection Journal of Immunology 194: 1100 - 1111. Tsatsaronis J.A., Ly D., Pupovac A., *Goldmann O., *Rohde M., Taylor J.M., Walker M.J., *Medina E., Sanderson-Smith M.L. (2015) Group A Streptococcus Modulates Host Inflammation by Manipulating Polymorphonuclear Leukocyte Cell Death Responses Journal of Innate Immunity 7: 612 - 622. *Loof T.G., *Deicke C., *Medina E. (2014) The role of coagulation/fibrinolysis during Streptococcus pyogenes infection Frontiers in Cellular and Infection Microbiology 4: 128. *Mehraj J., *Akmatov M.K., *Strompl J., *Gatzemeier A., Layer F., Werner G., *Pieper D.H., *Medina E., Witte W., *Pessler F., *Krause G. (2014) Methicillin-sensitive and methicillin-resistant Staphylococcus aureus nasal carriage in a random sample of non-hospitalized adult population in Northern Germany PLoS ONE 9: e107937. *Szafranska A.K., *Oxley A.P.A., *Chaves-*Moreno D., *Horst S.A., Rosslenbroich S., Peters G., *Goldmann O., *Rohde M., Sinha B., *Pieper D.H., Loffler B., *Jauregui R., *Wos-Oxley M.L., *Medina E. (2014) High-resolution transcriptomic analysis of the adaptive response of Staphylococcus aureus during acute and chronic phases of osteomyelitis mBio 5: e01775-14. Yuan D., Zhu Z., Tan X., Liang J., Zeng C., Zhang J., Chen J., Ma L., Dogan A., Brockmann G., *Goldmann O., *Medina E., Rice A.D., Moyer R.W., Man X., Yi K., Li Y., Lu Q., Huang Y., Huang S. (2014) Scoring the collective effects of SNPs: association of minor alleles with complex traits in model organisms Science China Life Sciences 57: 876 - 888. *Goldmann O., *Medina E. (2013) The expanding world of extracellular traps: Not only neutrophils but much more Frontiers in Immunology 3: Article 420. *Horst S.A., Linner A., Beineke A., *Lehne S., *Holtje C., *Hecht A., Norrby-Teglund A., *Medina E., *Goldmann O. (2013) Prognostic value and therapeutic potential of TREM-1 in Streptococcus pyogenes-induced sepsis Journal of Innate Immunity 5: 581 - 590. Ko Y.-P., Kuipers A., Freitag C.M., Jongerius I., *Medina E., van Rooijen W.J., Spaan A.N., van Kessel K.P.M., Hook M., Rooijakkers S.H.M. (2013) Phagocytosis Escape by a Staphylococcus aureus Protein That Connects Complement and Coagulation Proteins at the Bacterial Surface PLoS Pathogens 9: 1 - 13. Michelucci A., Cordes T., Ghelfi J., Pailot A., Reiling N., *Goldmann O., Binz T., Wegner A., Tallam A., Rausell A., Buttini M., Linster C.L., *Medina E., Balling R., Hiller K. (2013) Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production Proceedings of the

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*Dehghany J., Sönmez A., Münster C., *Meyer-Hermann M., Guck J., Kalaidzidis Y., Solimena M. (2016) The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512 Molecular Metabolism 5: 656 - 668. Nakagawa R., Leyland R., *Meyer-Hermann M., Lu D., Turner M., Arbore G., Phan T.G., Brink R., Vigorito E. (2016) MicroRNA-155 controls affinity-based selection by protecting c-MYC+ B cells from apoptosis Journal of Clinical Investigation 126: 377 - 388. Tas J.M., Mesin L., Pasqual G., Targ S., Jacobsen J.T., Mano Y.M., Chen C.S., Weill J.C., Reynaud C.A., Browne E.P., *Meyer-Hermann M., Victora G.D. (2016) Visualizing antibody affinity maturation in germinal centers Science 351: 1048 - 1054. *Binder S.C., *Hernandez-Vargas E.A., *Meyer-Hermann M. (2015) Reducing complexity: An iterative strategy for parameter determination in biological networks Computer Physics Communications 190: 15 - 22. *Boianelli A., *Nguyen,V.K., *Ebensen T., *Schulze K., *Wilk E., *Sharma N., *Stegemann-*Koniszewski S., *Bruder D., Toapanta F.R., *Guzmán C.A., *Meyer-Hermann M., *Hernandez-Vargas E.A. (2015) Modeling influenza virus infection: A roadmap for influenza research Viruses 7: 5274 - 5304. *Dehghany J., Hoboth P., Ivanova A., Mziaut H., Muller A., Kalaidzidis Y., Solimena M., *Meyer-Hermann M. (2015) A Spatial Model of Insulin-Granule Dynamics in Pancreatic ß-Cells Traffic 16: 797 - 813. *Hatzikirou H., Alfonso J.C., *Mühle S., *Stern C., *Weiss S., *Meyer-Hermann M. (2015) Cancer therapeutic potential of combinatorial immuno- and vasomodulatory interventions Journal of the Royal Society Interface 12: 20150439. Hoboth P., Muller A., Ivanova A., Mziaut H., *Dehghany J., Sonmez A., Lachnit M., *Meyer-Hermann M., Kalaidzidis Y., Solimena M. (2015) Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies Proceedings of the National Academy of Sciences of the United States of America 112: E667 - E676. *Kempf H., Bleicher M., *Meyer-Hermann M. (2015) Spatio-temporal dynamics of hypoxia during radiotherapy PLoS ONE 10: e0133357. *Milanez-Almeida P., *Meyer-Hermann M., *Toker A., *Khailaie S., *Hühn J. (2015) Foxp3+ regulatory T-cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen European Journal of Immunology 45: 153 - 166. *Nguyen V.K., *Binder S.C., *Boianelli A., *Meyer-Hermann M., *Hernandez-Vargas E.A. (2015) Ebola virus infection modeling and identifiability problems Frontiers in Microbiology 6: 257 - 257. *Sukhorukov V.M., *Meyer-Hermann M. (2015) Structural Heterogeneity of Mitochondria Induced by the Microtubule Cytoskeleton Scientific Reports 5: 13924. *Haering M., Hordt A., *Meyer-Hermann M., *Hernandez-Vargas E.A. (2014) Computational study to determine when to initiate and alternate therapy in HIV infection BioMed Research International 2014: 472869. *Hernandez-Vargas E.A., *Wilk E., Canini L., Toapanta F.R., *Binder S.C., *Uvarovskii A., Ross T.M.,

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*Guzmán C.A., Perelson A.S., *Meyer-Hermann M. (2014) Effects of aging on influenza virus infection dynamics Journal of Virology 88: 4123 - 4131. Jain H.V., Richardson A., *Meyer-Hermann M., Byrne H.M. (2014) Exploiting the synergy between Carboplatin and ABT-737 in the treatment of ovarian carcinomas PLoS ONE 9: e81582. Jiao Y., Lau T., *Hatzikirou H., *Meyer-Hermann M., Corbo J.C., Torquato S. (2014) Avian photoreceptor patterns represent a disordered hyperuniform solution to a multiscale packing problem Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 89: 22721. *Khailaie S., *Robert P.A., *Toker A., *Hühn J., *Meyer-Hermann M. (2014) A signal integration model of thymic selection and natural regulatory T cell commitment Journal of Immunology 193: 5983 - 5996. *Meyer-Hermann M. (2014) Overcoming the dichotomy of quantity and quality in antibody responses Journal of Immunology 193: 5414 - 5419. *Milanez-Almeida P., *Klawonn F., *Meyer-Hermann M., *Hühn J. (2014) Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen European Journal of Microbiology and Immunology 4: 147 - 155. *Zhao G., Dharmadhikari G., Maedler K., *Meyer-Hermann M. (2014) Possible Role of Interleukin-1ß in Type 2 Diabetes Onset and Implications for Anti-inflammatory Therapy Strategies PLoS Computational Biology 10: e1003798. He J.-S., *Meyer-Hermann M., Xiangying D., Zuan L.Y., Jones L.A., Ramakrishna L., Vries V.C.D., Dolpady J., Aina H., Joseph S., Narayanan S., Subramaniam S., Puthia M., Wong G., Xiong H., Poidinger M., Urban J.F., Lafaille J.J., Lafaille M.A.C. (2013) The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response Journal of Experimental Medicine 210: 2755 - 2771. *Kempf H., *Hatzikirou H., Bleicher M., *Meyer-Hermann M. (2013) In Silico Analysis of Cell Cycle Synchronisation Effects in Radiotherapy of Tumour Spheroids PLoS Computational Biology 9: e1003295. *Khailaie S., Bahrami F., Janahmadi M., *Milanez-*Almeida P., *Hühn J., *Meyer-Hermann M. (2013) A mathematical model of immune activation with a unified self-nonself concept Frontiers in Immunology 4: Article 474. *Schmeitz C., *Hernandez-Vargas E.A., Fliegert R., Guse A.H., *Meyer-Hermann M. (2013) A mathematical model of T lymphocyte calcium dynamics derived from single transmembrane protein properties Frontiers in Immunology 4: Article 277. Zhang Y., *Meyer-Hermann M., George L.A., Figge M.T., Khan M., Goodall M., Young S.P., Reynolds A., Falciani F., Waisman A., Notley C.A., Ehrenstein M.R., Kosco-Vilbois M., Toellner K.-M. (2013) Germinal center B cells govern their own fate via antibody feedback Journal of Experimental Medicine 210: 457 - 464.

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Müller, Andreas J.

Glodde N., Bald T., Boorn-Konijnenberg D., Nakamura K., Szczepanski S., Brandes M., Eickhoff S., Shridhar N., Hinze D., Rogava M., van der Sluis T., Ruotsalainen J., Gaffal G., Landsberg J., Ludwig K., Wilhelm C., Riek-Burchardt M., *Müller A.J., Gebhardt C., Janzen V., Kastenmüller W., Smyth M., Mazzone M., Tüting T., Hölzel M. (2017) c-MET dependent reactive neutrophil responses limit immunotherapy of cancer Immunity 47: 789 - 802. Hurrell B.P., Beaumann M., *Heyde S., Regli I.B., *Müller A.J., Tacchini-Cottier F. (2017) Frontline science: Leishmania mexicana amastigotes can replicate within neutrophils Journal of Leukocyte Biology 102: 1187 - 1198. Madhusudhan T., Wang H., Ghosh S., Dong W., Kumar V., Al-Dabet M.M., Manoharan J., Nazir S., Elwakiel A., Bock F., Kohli S., Marquardt A., Sögüt I., Shahzad K., Müller A.J., Esmon C.T., Nawroth P.P., Reiser J., Chavakis T., Ruf W., Isermann B. (2017) Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function Blood 130: 1445 - 1455. Philipsen L., Reddycherla A.V., Hartig R., Gumz J., Kästle M., Kritikos A., Poltorak M.P., Prokazov Y., Turbin E., Weber A., Zuschratter W., *Schraven B., Simeoni L., *Müller A.J. (2017) De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling Science Signaling 10: eaaf4736. *van Ham M., *Teich R., Philipsen L., *Niemz J., *Amsberg N., *Wissing J., *Nimtz M., *Gröbe L., Kliche S., *Thiel N., *Klawonn F., Hubo M., Jonuleit H., Reichardt P., *Müller A.J., *Hühn J., *Jänsch L. (2017) TCR signalling network organization at the immunological synapses of murine regulatory T cells European Journal of Immunology 47: 2043 - 2058. *Volckmar J., *Gereke M., *Ebensen T., *Riese P., Philipsen L., *Lienenklaus S., Wohlleber D., *Klopfleisch R., *Stegemann-Koniszewski S., *Müller A.J., Gruber A.D., Knolle P., *Guzmán C.A., Bruder D. (2017) Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver Scientific Reports 7: 43985. Witte A., Meineke B., Sticht J., Philipsen L., Kuropka B., *Müller A.J., Freund C., *Schraven B., Kliche S. (2017) D120 and K152 within the PH domain of T cell adapter SKAP55 regulate plasma membrane targeting of SKAP55 and LFA-1 affinity modulation in human T lymphocytes Molecular and Cellular Biology 37: e00509-16. Möhle L., Israel N., Paarmann K., Krohn M., Pietkiewicz S., *Müller A., Lavrik I.N., Buguliskis J.S., Schott B.H., Schlüter D., Gundelfinger E.D., Montag D., Seifert U., Pahnke J., Dunay I.R. (2016) Chronic Toxoplasma gondii infection enhances ß-amyloid phagocytosis and clearance by recruited monocytes Acta Neuropathologica Communications 4: 25. Hurrell B.P., Schuster S., Grün E., Coutaz M., Williams R.A., Held W., Malissen B., Malissen M., Yousefi S., Simon H.U., *Müller A.J., Tacchini-Cottier F. (2015) Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion PLoS Pathogens 11: e1004929.

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Pessler Frank C.

*Kuhn M., Sühs K.W., *Akmatov M.K., *Klawonn F., *Wang J., Skripuletz T., Kaever V., Stangel M.,

*Pessler F. (2018) Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers

for CNS involvement in varicella-zoster virus reactivation J of Neuroinflammation 15:20.

*Samir M., Hamed M., Abdallah F., *Kinh Nguyen V., *Hernandez-Vargas E.A., Seehusen F.,

Baumgärtner W., Hussein A., Ali A.A.H., *Pessler F. (2018) An Egyptian HPAI H5N1 isolate from clade

2.2.1.2 is highly pathogenic in an experimentally infected domestic duck breed (Sudani duck).

Transboundary and Emerging Diseases doi: 10.1111/tbed.12816.

*Akmatov M.K., *Jentsch L., *Riese P., May M., *Ahmed M.W., *Werner D., *Rösel A., Prokein J.,

Bernemann I., Klopp N., *Prochnow B., Illig T., Schindler C., *Guzmán C.A., *Pessler F. (2017)

Motivations for (non)participation in population-based health studies among the elderly -

comparison of participants and nonparticipants of a prospective study on influenza vaccination BMC

Medical Research Methodology 17: 1 - 9.

*Akmatov M.K., *Riese P., May M., *Jentsch L., Ahmed M.W., *Werner D., *Rösel A., Tyler M.,

*Pessler K., Prokein J., Bernemann I., Klopp N., *Prochnow B., *Trittel S., *Tallam A., Illig T., Schindler

C., *Guzmán C.A., *Pessler F. (2017) Establishment of a cohort for deep phenotyping of the immune

response to influenza vaccination among elderly individuals recruited from the general population

Human Vaccines and Immunotherapeutics 13: 1630 - 1639.

*Akmatov MK, *Koch N, *Vital M, Ahrens W, Flesch-Janys D, Fricke J, *Gatzemeier A, Greiser KH,

Günther K, Illig T, Kaaks R, Krone B, Kühn A, Linseisen J, Meisinger C, Michels K, Moebus S, Obi N,

Nieters A, Schultze A, Six-Merker J, *Pieper DH, *Pessler F. (2017) Determination of nasal and

oropharyngeal microbiomes in a multicenter population-based study – findings of the Pretest 1

phase of the German National Cohort. Scientific Reports; 7:1855.

*Akmatov M.K., Röber N., Ahrens W., Flesch-Janys D., Fricke J., Greiser H., Günther K., Kaaks R.,

*Kemmling Y., Krone B., Linseisen J., Meisinger C., Moebus S., Obi N., *Guzmán C.A., Conrad K.,

*Pessler F. (2017) Anti-nuclear autoantibodies in the general German population: Prevalence and

lack of association with selected cardiovascular and metabolic disorders-findings of a multicenter

population-based study Arthritis Research and Therapy 19: 127.

Filomena A., *Pessler F., *Akmatov M.K., *Krause G., Duffy D., Gärtner B., Gerhard M., Albert M.L.,

Joos T.O., Schneiderhan-Marra N. (2017) Development of a bead-based multiplex assay for the

analysis of the serological response against the six pathogens HAV, HBV, HCV, CMV, T. gondii, and

H. pylori High-Throughput 6: 14.

Karabaev B.B., Beisheeva N.J., Satybaldieva A.B., Ismailova A.D., *Pessler F., *Akmatov M.K. (2017)

Seroprevalence of hepatitis B, hepatitis C, human immunodeficiency virus, Treponema pallidum, and

co-infections among blood donors in Kyrgyzstan: A retrospective analysis (2013-2015) Infectious

Diseases of Poverty 6: 45.

Krenn V., Perino G., Rüther W., Krenn V.T., Huber M., Hügle T., Najm A., Müller S., Boettner F.,

*Pessler F., Waldstein W., Kriegsmann J., Casadonte R., Häupl T., Wienert S., Krukemeyer M.G.,

Sesselmann S., Sunitsch S., Tikhilov R., Morawietz L. (2017) 15 years of the histopathological synovitis

score, further development and review: A diagnostic score for rheumatology and orthopaedics

145

Pathology Research and Practice 213: 874 - 881.

Krenn V., Perino G., Rüther W., Krenn V.T., Huber M., Hügle T., Najm A., Müller S., Boettner F.,

*Pessler F., Waldstein W., Kriegsmann J., Häupl T., Wienert S., Krukemeyer M.G., Sesselmann S.,

Tikhilov R., Morawietz L. (2017) Fifteen years of the histopathological synovitis score: Review and

further developments of a diagnostic score [15 Jahre histopathologischer Synovialitis-Score:

Rückblick und Weiterentwicklung eines diagnostischen Scores] Zeitschrift fur Rheumatologie 76: 539

- 546.

*Preusse M., *Schughart K., *Pessler F. (2017) Host genetic background strongly affects pulmonary

microRNA expression before and during influenza A virus infection Frontiers in Immunology 8: 246.

*Akmatov M.K., Stumme M., *Pessler F. (2016) Real-life practice of methotrexate toxicity monitoring

in juvenile idiopathic arthritis in Germany, Switzerland and Austria: results of a cross-sectional

assessment conducted in 2012 Clinical and experimental rheumatology 34: 548 - 553.

de Araujo L.S., *Vaas L.A.I., Ribeiro-Alves M., *Geffers R., Mello F.C.Q., de Almeida A.S., Moreira

A.S.R., Kritski A.L., Lapa e Silva J.R., Moraes M.O., *Pessler F., Saad M.H.F. (2016) Transcriptomic

biomarkers for tuberculosis: Evaluation of DOCK9, EPHA4, and NPC2 mRNA expression in peripheral

blood Frontiers in Microbiology 7: 1586.

Elsaman A.M., Muhammad E.M., *Pessler F. (2016) Sonographic Findings in Gouty Arthritis:

Diagnostic Value and Association with Disease Duration Ultrasound in Medicine and Biology 42:

1330 - 1336.

Hendel N., *Akmatov M.K., Hamel J., Vogelberg C., *Pessler F. (2016) Exhaled breath analysis in

childhood rheumatic disorders - A longitudinal study Journal of Breath Research 10: 21001.

*Samir M., *Pessler F. (2016) Small Non-coding RNAs Associated with Viral Infectious Diseases of

Veterinary Importance: Potential Clinical Applications Frontiers in Veterinary Science 3: 22.

eCollection 2016. Review.

*Samir M., *Vaas L.A., *Pessler F. (2016) MicroRNAs in the Host Response to Viral Infections of

Veterinary Importance Frontiers in Veterinary Science 3: 86. eCollection 2016. Review.

Schlett C.L., Hendel T., Hirsch J., Weckbach S., Caspers S., Schulz-Menger J., Ittermann T., von

Knobelsdorff-Brenkenhoff F., Ladd S.C., Moebus S., Stroszczynski C., Fischer B., Leitzmann M., Kuhl C.,

*Pessler F., Hartung D., *Kemmling Y., Hetterich H., A (2016) Quantitative, Organ-Specific

Interscanner and Intrascanner Variability for 3 T Whole-Body Magnetic Resonance Imaging in a

Multicenter, Multivendor Study Investigative Radiology 51: 255 - 265.

*Schweitzer A., *Pessler F., *Akmatov M.K. (2016) Impact of rotavirus vaccination on coverage and

timing of pentavalent vaccination - Experience from 2 Latin American countries Human Vaccines and

Immunotherapeutics 12: 1250 - 1256.

*Abd-Elshafy D., *Pietschmann T., Muller-Ladner U., Neumann E., *Anggakusuma, *Bahgat M.M,

*Pessler F., *Behrendt P. (2015) Cell culture-derived HCV cannot infect synovial fibroblasts Scientific

Reports 5: 18043.

146



percentages in a Web-based study, but in similar compliance International Journal of Public Health

60: 937 - 943.

*Akmatov M.K., Kimani-Murage E., *Pessler F., *Guzmán C.A., *Krause G., Kreienbrock L.,



*Preusse M., *Schughart K., *Wilk E., *Klawonn F., *Pessler F. (2015) Hematological parameters in

the early phase of influenza A virus infection in differentially susceptible inbred mouse strains

Infectious Diseases BMC Research Notes 8: 225.

*Schweitzer A., *Akmatov M.K., *Kindler F., *Kemmling Y., Kreienbrock L., *Krause G., *Pessler F.

(2015) The impact of distance and duration of travel on participation rates and participants'

satisfaction: Results from a pilot study at one study centre in Pretest 2 of the German National

Cohort BMJ Open 5: e007461.

*Schweitzer A., *Della Beffa C., *Akmatov M.K., Narchi H., Abaev Y.K., Sherry D.D., *Pessler F. (2015)

Primary osteomyelitis of the sternum in the pediatric age group: Report of a new case and

comprehensive analysis of seventy-four cases Pediatric Infectious Disease Journal 34: e92 - e101.

*Schweitzer A., *Krause G., *Pessler F., *Akmatov M.K. (2015) Improved coverage and timing of

childhood vaccinations in two post-Soviet countries, Armenia and Kyrgyzstan BMC Public Health 15:

798.

*Akmatov M.K., *Mehraj J., *Gatzemeier A., *Strömpl J., Witte W., *Krause G., *Pessler F. (2014)

Serial home-based self-collection of anterior nasal swabs to detect Staphylococcus aureus carriage in

a randomized population-based study in Germany International Journal of Infectious Diseases 25: e4

- e10.

*Castell S., *Akmatov M.K., Obi N., Flesh-Janys D., Nieters A., *Kemmling Y., *Pessler F., *Krause G.

(2014) Test–retest reliability of an infectious disease questionnaire and evaluation of self-assessed

vulnerability to infections: Findings of Pretest 2 of the German National Cohort [Test-Retest-

Reliabilität eines Fragebogens zu Infektionskrankheiten und Evalui Bundesgesundheitsblatt -


Kuhn A., Nieters A., Kottgen A., Goek O.N., Michels K., Nothlings U., Jacobs G., Meisinger C., *Pessler

F., *Akmatov M.F., Kuhnisch J., Moebus S., Glocker E., Naus S., Keimling M., Leitzmann M., Linseisen

J., Sarioglu H., von Toerne C., Hauck S.M., Wallas (2014) Feasibility and quality development of

biomaterials in the pretest studies of the German National Cohort [Machbarkeitsprüfung und

Qualitätsentwicklung zur Gewinnung von Biomaterialien in den Pretest-Studien der Deutschen

Nationalen Kohorte] Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 57: 1255

- 1263.

*Mall S., *Akmatov M.K., *Schultze A., Ahrens W., Obi N., *Pessler F., *Krause G. (2014) Web-based

questionnaires to capture acute infections in long-term cohorts: Findings of a feasibility study [Web-

147

basierte Erhebungen zur Erfassung akuter Infektionen in Langzeitkohorten: Ergebnisse einer

Machbarkeitsstudie] Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 57: 1308

- 1314.

*Mehraj J., *Akmatov M.K., *Strömpl J., *Gatzemeier A., Layer F., Werner G., *Pieper D.H., *Medina




*Novoselova N., *Della Beffa C., *Wang J., Li J., *Pessler F., *Klawonn F. (2014) HUM calculator and

HUM package for R: Easy-to-use software tools for multicategory receiver operating characteristic

analysis Bioinformatics 30: 1635 - 1636.

*Pessler F., Ogdie A.R., *Mayer C.T., Kretzschmar W.W., Dai L., *Elsaman A.M., Einhorn E., Krenn V.,

Schumacher H.R. (2014) Amyloid arthropathy associated with multiple myeloma: Polyarthritis

without synovial infiltration of CD20+ or CD38+ cells Amyloid 21: 28 - 34.

*Schultze A., *Akmatov M.K., *Andrzejak M., Karras N., *Kemmling Y., *Maulhardt A., *Wieghold S.,

Ahrens W., Gunther K., Schlenz H., *Krause G., *Pessler F. (2014) Comparison of stool collection on

site versus at home in a population-based study: Feasibility and participants’ preference in Pretest 2

of the German National Cohort Bundesgesundheitsblatt - Gesundheitsforschung -

Gesundheitsschutz 57: 1264 - 1269.

*Schultze A., *Akmatov M.K., *Castell S., *Karch A., Ahrens W., Gunther K., Schlenz H., Flesch-Janys

D., Obi N., *Pessler F., *Krause G. (2014) Collection of vaccination data in the German National

Cohort: Findings of a feasibility study in three study centers [Impfdatenerhebung in der Nationalen

Kohorte: Ergebnisse einer Machbarkeitsstudie in drei Studienzentren] Bundesgesundheitsblatt -


*Della Beffa C., Slansky E., *Pommerenke C., *Klawonn F., Li J., Dai L., Schumacher Jr. H.R., *Pessler F.

(2013) The Relative Composition of the Inflammatory Infiltrate as an Additional Tool for Synovial

Tissue Classification PLoS ONE 8: e72494.

Elsaman A.M., Radwan A.R., *Akmatov M.K., *Della Beffa C., *Walker A., *Mayer C.T., Dai L., Nativ S.,

Rygg M., Atsali E., Saijo K., Ogdie A.R., Srinivasulu N., Fathi N., Schumacher H.R., *Pessler F. (2013)

Amyloid arthropathy associated with multiple myeloma: A systematic analysis of 101 reported cases

Seminars in Arthritis and Rheumatism 43: 405 - 412.

*Klawonn F., Jayaram B., *Crull K., Kukita A., *Pessler F. (2013) Analysis of contingency tables based

on generalized median polish with power transformations and non-additive models Health

Information Science & Systems 1: 11.

*Preusse M., *Tantawy M.A., *Klawonn F., *Schughart K., *Pessler F. (2013) Infection- and

procedure-dependent effects on pulmonary gene expression in the early phase of influenza A virus

infection in mice BMC Microbiology 13: 293.

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Schmitz, Ingo

*Chaudhry M.Z., *Kasmapour B., *Plaza-Sirvent C., Bajagic M., *Garduño R.C., *Borkner L., Roviš T.L., *Scrima A., Jonjic S., *Schmitz I., *Cicin-Sain L. (2017) UL36 rescues apoptosis inhibition and in vivo replication of a chimeric MCMV lacking the M36 gene Frontiers in Cellular and Infection Microbiology 7: 312. *Plaza-Sirvent C., *Schuster M., *Neumann Y., *Heise U., *Pils M.C., Schulze-Osthoff K., *Schmitz I. (2017) c-FLIP Expression in Foxp3-Expressing Cells Is Essential for Survival of Regulatory T Cells and Prevention of Autoimmunity Cell Reports 18: 12 - 22. *Schuster M., *Plaza-Sirvent C., *Matthies A.-M., *Heise U., *Jeron A., *Bruder D., Visekruna A., *Hühn J., *Schmitz I. (2017) C-REL and IκBNS govern common and independent steps of regulatory T cell development from novel CD122-expressing pre-precursors Journal of Immunology 199: 920 - 930. *Zhao G., *Wirth D., *Schmitz I., *Meyer-Hermann M. (2017) A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance Nature Communications 8: 1362. Annemann M., *Plaza-Sirvent C., *Schuster M., *Katsoulis-Dimitriou K., Kliche S., *Schraven B., *Schmitz I. (2016) Atypical IκB proteins in immune cell differentiation and function Immunology Letters 171: 26 - 35. *Neumann Y., *Bruns S.A., *Rohde M., Prajsnar T.K., Foster S.J., *Schmitz I. (2016) Intracellular Staphylococcus aureus eludes selective autophagy by activating a host cell kinase Autophagy 12: 2069 - 2084. Sosna J., Philipp S., Chico J.F., Saggau C., Fritsch J., Föll A., Plenge J., Arenz C., Pinkert T., Kalthoff H., Trauzold A., *Schmitz I., Schütze S., Adam D. (2016) Differences and similarities in TRAIL- and tumor necrosis factor-mediated necroptotic signaling in cancer cells Molecular and Cellular Biology 36: 2626 - 2644. *Annemann M., *Wang Z., *Plaza-Sirvent C., Glauben R., *Schuster M., *Sander F.E., *Mamareli P., Kuhl A.A., Siegmund B., *Lochner M., *Schmitz I. (2015) IκBNS regulates murine Th17 differentiation during gut inflammation and infection Journal of Immunology 194: 2888 - 2898. *Bronietzki A.W., *Schuster M., *Schmitz I. (2015) Autophagy in T-cell development, activation and differentiation Immunology and Cell Biology 93: 25 - 34. Bou-Hanna C., Jarry A., Lode L., *Schmitz I., Schulze-Osthoff K., Kury S., Bezieau S., Mosnier J.-F., Laboisse C.L. (2015) Acute cytotoxicity of MIRA-1/NSC19630, a mutant p53-reactivating small molecule, against human normal and cancer cells via a caspase-9-dependent apoptosis Cancer Letters 359: 211 - 217. *Ewald F., *Annemann M., *Pils M.C., *Plaza-Sirvent C., Neff F., *Erck C., *Reinhold D., *Schmitz I. (2014) Constitutive expression of murine c-FLIP causes autoimmunity in aged mice Cell Death and Disease 5: e1168. Franco R., Bortner C.D., *Schmitz I., Cidlowski J.A. (2014) Glutathione depletion regulates both extrinsic and intrinsic apoptotic signaling cascades independent from multidrug resistance protein 1 Apoptosis 19: 117 - 134. Jeltsch K.M., Hu D., Brenner S., Zoller J., Heinz G.A., Nagel D., Vogel K.U., Rehage N., Warth S.C.,

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Edelmann S.L., Gloury R., Martin N., Lohs C., Lech M., Stehklein J.E., Geerlof A., Kremmer E., Weber A., Anders H.-J., *Schmitz I., Schmidt-Supprian M., F (2014) Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation Nature Immunology 15: 1079 - 1089. Knievel J., Schulz W.A., Greife A., Hader C., *Lubke T., *Schmitz I., Albers P., Niegisch G. (2014) Multiple mechanisms mediate resistance to Sorafenib in urothelial cancer International Journal of Molecular Sciences 15: 20500 - 20517. *Schreiber L., *Pietzsch B., *Flöss S., *Farah C., *Jänsch L., *Schmitz I., *Hühn J. (2014) The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-κB signaling PLoS ONE 9: e88318. *Hocker R., *Walker A., *Schmitz I. (2013) Inhibition of autophagy through MAPK14-mediated phosphorylation of ATG5 Autophagy 9: 426 - 428. *Schmitz I. (2013) Gadd45 proteins in immunity Advances in Experimental Medicine and Biology 793: 51 - 68. *Schuster M., *Annemann M., *Plaza-Sirvent C., *Schmitz I. (2013) Atypical IкB proteins - nuclear modulators of NF-кB signaling. Cell Communication and Signaling 11: 23. *Telieps T., *Ewald F., *Gereke M., *Annemann M., *Rauter Y., *Schuster M., *Ueffing N., von Smolinski D., Gruber A.D., *Bruder D., *Schmitz I. (2013) Cellular-FLIP, Raji isoform (c-FLIPR) modulates cell death induction upon T-cell activation and infection European Journal of Immunology 43: 1499 - 1510. Hildebrand D.G., Alexander E., HoNrber S., Lehle S., Obermayer K., Munck N.-A., Rothfuss O., Frick J.-S., Morimatsu M., *Schmitz I., Roth J., Ehrchen J.M., Essmann F., Schulze-Osthoff K. (2013) IкBζ is a transcriptional key regulator of CCL2/MCP-1 Journal of Immunology 190: 4812 - 4820. Keil E., *Hocker R., *Schuster M., Essmann F., Ueffing N., Hoffman B., Liebermann D.A., Pfeffer K., Schulze-Osthoff K., *Schmitz I. (2013) Phosphorylation of Atg5 by the Gadd45β-MEKK4-p38 pathway inhibits autophagy Cell Death and Differentiation 20: 321 - 332.

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*Parzmair G.P., *Gereke M., *Haberkorn O., Annemann M., Podlasly L., Kliche S., Reinhold A., *Schraven B., *Bruder D. (2017) ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens Journal of Leukocyte Biology 101: 407 - 419. Philipsen L., Reddycherla A.V., Hartig R., Gumz J., Kästle M., Kritikos A., Poltorak M.P., Prokazov Y., Turbin E., Weber A., Zuschratter W., *Schraven B., Simeoni L., *Müller A.J. (2017) De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling Science Signaling 10: eaaf4736. Ranjan S., Goihl A., Kohli S., Gadi I., Pierau M., Shahzad K., Gupta D., Bock F., Wang H., Shaikh H., Kähne T., Reinhold D., Bank U., Zenclussen A.C., *Niemz J., Schnöder T.M., Brunner-Weinzierl M., Fischer T., Kalinski T., *Schraven B., Luft T., *Hühn J (2017) Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells Nature Communications 8: 311. Raza S.A., Albrecht A., Çallskan G., Müller B., Demiray Y.E., Ludewig S., Meis S., Faber N., Hartig R., *Schraven B., Lessmann V., Schwegler H., Stork O. (2017) HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience Nature Communications 8: 189. Thurm C., Poltorak M.P., *Reimer E., *Brinkmann M.M., Leichert L., *Schraven B., Simeoni L. (2017) A highly conserved redox-active Mx(2)CWx(6)R motif regulates Zap70 stability and activity Oncotarget 8: 30805 - 30816. Witte A., Meineke B., Sticht J., Philipsen L., Kuropka B., *Müller A.J., Freund C., *Schraven B., Kliche S. (2017) D120 and K152 within the PH domain of T cell adapter SKAP55 regulate plasma membrane targeting of SKAP55 and LFA-1 affinity modulation in human T lymphocytes Molecular and Cellular Biology 37: e00509-16. Annemann M., *Plaza-Sirvent C., *Schuster M., *Katsoulis-Dimitriou K., Kliche S., *Schraven B., *Schmitz I. (2016) Atypical IκB proteins in immune cell differentiation and function Immunology Letters 171: 26 - 35. Cammann C., Rath A., Reichl U., Lingel H., Brunner-Weinzierl M., Simeoni L., *Schraven B., Lindquist J.A. (2016) Early changes in the metabolic profile of activated CD8+ T cells BMC Cell Biology 17: 28. Hrdinka M., Sudan K., Just S., Drobek A., Stepanek O., *Schlüter D., Reinhold D., Jordan B.A., Gintschel P., *Schraven B., Kreutz M.R. (2016) Normal development and function of T cells in proline rich 7 (Prr7) deficient mice PLoS ONE 11: e0162863. Kuropka B., *Schraven B., Kliche S., Krause E., Freund C. (2016) Tyrosine-phosphorylation of the scaffold protein ADAP and its role in T cell signaling Expert Review of Proteomics 13: 545 - 554. Lowinus T., Bose T., Busse S., Busse M., Reinhold D., *Schraven B., Bommhardt U.H.H. (2016) Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of Kv1.3 channels and T cell responsiveness Oncotarget 7: 53797 - 53807. Perner F., Schnöder T.M., Ranjan S., Wolleschak D., Ebert C., *Pils M.C., Frey S., Polanetzki A., Fahldieck C., Schönborn U., *Schraven B., Isermann B., Fischer T., Heidel F.H. (2016) Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function Leukemia 30: 991 - 995.

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Hasenberg A., Hasenberg M., Mann L., Neumann F., Borkenstein L., Stecher M., Kraus A., Engel D.R., Klingberg A., Seddigh P., Abdullah Z., Klebow S., Engelmann S., Reinhold A., Brandau S., Seeling M., Waisman A., *Schraven B., Gothert J.R., Nimmerjahn F., (2015) Catchup: A mouse model for imaging-based tracking and modulation of neutrophil granulocytes Nature Methods 12: 445 - 452. Kuropka B., Witte A., Sticht J., Waldt N., Majkut P., Hackenberger C.P.R., *Schraven B., Krause E., Kliche S., Freund C. (2015) Analysis of phosphorylation-dependent protein interactions of adhesion and degranulation promoting adaptor protein (ADAP) reveals novel interaction partners required for chemokine-directed T cell migration Molecular and Cellular Proteomics 14: 2961 - 2972. Reddycherla A.V., Meinert I., Reinhold A., Reinhold D., *Schraven B., Simeoni L. (2015) miR-20a inhibits TCR-mediated signaling and cytokine production in human naïve CD4+ T cells PLoS ONE 10: e125311. *Vogel S., *Grabski E., *Buschjäger D., *Klawonn F., *Döring M., *Wang J., Fletcher E., Bechmann I., Witte T., Durisin M., *Schraven B., Mangsbo S.M., Schönfeld K., Czeloth N., *Kalinke U. (2015) Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64+ cells Scientific Reports 5: 18308. Belikov A.V., *Schraven B., Simeoni L. (2014) TCR-triggered extracellular superoxide production is not required for T-cell activation Cell Communication and Signaling 12: 50. Mobashir M., Madhusudhan T., Isermann B., Beyer T., *Schraven B. (2014) Negative interactions and feedback regulations are required for transient cellular response Scientific Reports 4: 3718. Poltorak M., Meinert I., Stone J.C., *Schraven B., Simeoni L. (2014) Sos1 regulates sustained TCR-mediated Erk activation European Journal of Immunology 44: 1535 - 1540. Simma N., Bose T., Kahlfuss S., Mankiewicz J., Lowinus T., Luhder F., Schuler T., *Schraven B., Heine M., Bommhardt U. (2014) NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells Cell Communication and Signaling : 1 - 13. Wolleschak D., Mack T.S., Perner F., Frey S., Schnoder T.M., Wagner M.-C., Hoding C., *Pils M.C., Parkner A., Kliche S., *Schraven B., Hebel K., Brunner-Weinzierl M., Ranjan S., Isermann B., Lipka D.B., Fischer T., Heidel F.H. (2014) Clinically relevant doses of FLT3-kinase inhibitors quizartinib and midostaurin do not impair T-cell reactivity and function Haematologica 99: e90 - e93. Arndt B., Kalinski T., Reinhold D., Thielitz A., Roessner A., *Schraven B., Simeoni L. (2013) Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX Journal of Leukocyte Biology 93: 353 - 362. Arndt B., Poltorak M., Kowtharapu B.S., Reichardt P., Philipsen L., Lindquist J.A., *Schraven B., Simeoni L. (2013) Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation Journal of Immunological Methods 387: 276 - 283. Engelmann S., Togni M., Thielitz A., Reichardt P., Kliche S., Reinhold D., *Schraven B., Reinhold A. (2013) T cell-independent modulation of experimental autoimmune encephalomyelitis in ADAP-deficient mice Journal of Immunology 191: 4950 - 4959. Smida M., Cammann C., Gurbiel S., Kerstin N., Lingel H., Lindquist S., Simeoni L., Brunner-Weinzierl

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M.C., Suchanek M., *Schraven B., Lindquist J.A. (2013) PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells Cell Communication and Signaling 11: 28. Stirnweiss A., Hartig R., Gieseler S., Lindquist J.A., Reichardt P., Philipsen L., Simeoni L., Poltorak M., Merten C., Zuschratter W., Prokazov Y., Paster W., Stockinger H., Harder T., Gunzer M., *Schraven B. (2013) T cell activation results in conformational changes in the Src family kinase Lck to induce its activation Science Signaling 6: ra13.

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Scrima, Andrea

*Archna A., *Scrima A. (2017) Identification, biochemical characterization and crystallization of the central region of human ATG16L1 Acta Crystallographica Section F: Structural Biology Communications 73: 560 - 567. *Bajagic M.,* Archna A., *Büsing P., *Scrima A. (2017) Structure of the WD40-domain of human ATG16L1 Protein Science 26: 1828 - 1837. *Bock T., *Volz C., *Hering V., *Scrima A., *Müller R., *Blankenfeldt W. (2017) The AibR-isovaleryl coenzyme A regulator and its DNA binding site - a model for the regulation of alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus Nucleic Acids Research 45: 2166 - 2178. *Chaudhry M.Z., *Kasmapour B., *Plaza-Sirvent C., Bajagic M., *Garduño R.C., *Borkner L., Roviš T.L., *Scrima A., Jonjic S., *Schmitz I., *Cicin-Sain L. (2017) UL36 rescues apoptosis inhibition and in vivo replication of a chimeric MCMV lacking the M36 gene Frontiers in Cellular and Infection Microbiology 7: 312. *Leupold S., *Büsing P., Mas P.J., Hart D.J., *Scrima A. (2017) Structural insights into the architecture of the Shigella flexneri virulence factor IcsA/VirG and motifs involved in polar distribution and secretion Journal of Structural Biology 198: 19 - 27. *Sadana P., Mönnich M., Unverzagt C., *Scrima A. (2017) Structure of the Y. pseudotuberculosis adhesin InvasinE Protein Science 26: 1182 - 1195. *Bleckmann M., *Schmelz S., *Schinkowski C.,* Scrima A.,* van den Heuvel J. (2016) Fast plasmid based protein expression analysis in insect cells using an automated SplitGFP screen Biotechnology and Bioengineering 113: 1975 - 1983. Fiebig D., *Schmelz S., Zindel S., Ehret V., Beck J., Ebenig A., Ehret M., Fröls S., Pfeifer F., Kolmar H., Fuchsbauer H.-L., *Scrima A. (2016) Structure of the dispase autolysis-inducing protein from Streptomyces mobaraensis and glutamine cross-linking sites for transglutaminase Journal of Biological Chemistry 291: 20417 - 20426. *Kühne C., *Singer H.M., *Grabisch E., Codutti L., *Carlomagno T., *Scrima A., *Erhardt M. (2016) RflM mediates target specificity of the RcsCDB phosphorelay system for transcriptional repression of flagellar synthesis in Salmonella enterica Molecular Microbiology 101: 841 - 855. Siegmund V., *Schmelz S., Dickgiesser S., Beck J., Ebenig A., Fittler H., Frauendorf H., Piater B., Betz U.A.K., Avrutina O., *Scrima A., Fuchsbauer H.-L., Kolmar H. (2015) Locked by Design: A Conformationally Constrained Transglutaminase Tag Enables Efficient Site-Specific Conjugation Angewandte Chemie - International Edition 54: 13420 - 13424. Hofmeyer T., *Schmelz S., Degiacomi M.T., Dal Peraro M., Daneschdar M., *Scrima A., *Van Den Heuvel J., *Heinz D.W., Kolmar H. (2013) Arranged sevenfold: Structural insights into the C-terminal oligomerization domain of human C4b-binding protein Journal of Molecular Biology 425: 1302 - 1317. Shi T., Bunker R.D., Mattarocci S., Ribeyre C., Faty M., Gut H., *Scrima A., Rass U., Rubin S.M., Shore D., Thoma N.H. (2013) Rif1 and Rif2 shape telomere function and architecture through multivalent Rap1 interactions Cell 153: 1340 - 1353.

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Sparwasser, Tim

Alissafi T., Banos A., Boon L., *Sparwasser T., Ghigo A., Wing K., Vassilopoulos D., Boumpas D., Chavakis T., Cadwell K., Verginis P. (2017) Tregs restrain dendritic cell autophagy to ameliorate autoimmunity Journal of Clinical Investigation 127: 2789 - 2804. Bieber K., Sun S., Witte M., Kasprick A., Beltsiou F., Behnen M., Laskay T., Schulze F.S., Pipi E., Reichhelm N., Pagel R., Zillikens D., Schmidt E., *Sparwasser T., Kalies K., Ludwig R.J. (2017) Regulatory T cells suppress inflammation and blistering in pemphigoid diseases Frontiers in Immunology 8: 1628 . *Friedrich C., *Mamareli P., *Thiemann S., *Kruse F., *Wang Z., Holzmann B., *Strowig T., *Sparwasser T., *Lochner M. (2017) MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium PLoS pathogens 13: e1006357. *Minarrieta L., *Ghorbani P., *Sparwasser T., *Berod L. (2017) Metabolites: deciphering the molecular language between DCs and their environment Seminars in Immunopathology 39: 177 - 198. Popovic B., Golemac M., Podlech J., Zeleznjak J., Bilic-Zulle L., Lukic M.L., *Cicin-Sain L., Reddehase M.J., *Sparwasser T., Krmpotic A., Jonjic S. (2017) IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection PLoS Pathogens 13: e1006345. Semitekolou M., Morianos I., Banos A., Konstantopoulos D., Adamou-Tzani M., *Sparwasser T., Xanthou G. (2017) Dendritic cells conditioned by activin A-induced regulatory T cells exhibit enhanced tolerogenic properties and protect against experimental asthma Journal of Allergy and Clinical Immunology doi: 10.1016/j.jaci.2017.03.047. Singpiel A, Kramer J, Maus R, Stolper J, Bittersohl LF, Gauldie J, Kolb M, Welte T, *Sparwasser T, Maus UA. (2017) Adenoviral vector-mediated GM-CSF gene transfer improves anti-mycobacterial immunity in mice - role of regulatory T cells Immunobiology Immunobiology. 2017 Oct 26. pii: S0171-2985(17)30183-3. doi: 10.1016/j.imbio.2017.10.042. van der Vlugt L.E.P.M., Obieglo K., Ozir-Fazalalikhan A., *Sparwasser T., Haeberlein S., Smits H.H. (2017) Schistosome-induced pulmonary B cells inhibit allergic airway inflammation and display a reduced Th2-driving function International Journal for Parasitology 47: 545 - 554. Zischke J., *Mamareli P., Pokoyski C., Gabaev I., Buyny S., Jacobs R., Falk C.S., *Lochner M., *Sparwasser T., Schulz T.F., Kay-Fedorov P.C. (2017) The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion PLoS Pathogens 13: e1006454. *Almeida L., *Lochner M., *Berod L., *Sparwasser T. (2016) Metabolic pathways in T cell activation and lineage differentiation Seminars in Immunology 28: 514 - 524. *Berod L., *Sparwasser T. (2016) pDCs Take a Deep Breath to Fight Viruses Immunity 44: 1246 - 1248. *Dudek M., *Puttur F., *Arnold-Schrauf C., Kühl A.A., Holzmann B., Henriques-Normark B., *Berod L., *Sparwasser T. (2016) Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection Mucosal Immunology 9: 1288 - 1302. *Freitag J., *Berod L., Kamradt T., *Sparwasser T. (2016) Immunometabolism and autoimmunity

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Immunology and Cell Biology 94: 925 - 934. Knuschke T., Rotan O., Bayer W., Sokolova V., Hansen W., *Sparwasser T., Dittmer U., Epple M., Buer J., Westendorf A.M. (2016) Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection Retrovirology 13: 24. Mykicki N., Herrmann A.M., Schwab N., Deenen R., *Sparwasser T., Limmer A., Wachsmuth L., Klotz L., Köhrer K., Faber C., Wiendl H., Luger T.A., Meuth S.G., Loser K. (2016) Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease Science Translational Medicine 8: 362ra146. Navarro S., Pickering D.A., Ferreira I.B., Jones L., Ryan S., Troy S., Leech A., Hotez P.J., Zhan B., Laha T., Prentice R., *Sparwasser T., Croese J., Engwerda C.R., Upham J.W., Julia V., Giacomin P.R., Loukas A. (2016) Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma Science Translational Medicine 8: 362ra143. Perdicchio M., Ilarregui J.M., Verstege M.I., Cornelissen L.A.M., Schetters S.T.T., Engels S., Ambrosini M., Kalay H., Veninga H., Den Haan J.M.M., Van Berkel L.A., Samsom J.N., Crocker P.R., *Sparwasser T., *Berod L., Garcia-Vallejo J.J., Van Kooyk Y., U (2016) Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells Proceedings of the National Academy of Sciences of the United States of America 113: 3329 - 3334. *Puttur F., *Francozo M., *Solmaz G., *Bueno C., *Lindenberg M., *Gohmert M., *Swallow M., Tufa D., Jacobs R., *Lienenklaus S., Kühl A.A., *Borkner L., *Cicin-Sain L., *Holzmann B., Wagner H., *Berod L., *Sparwasser T. (2016) Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling Cell Reports 17: 1113 - 1127. Raha S., *Raud B., Oberdörfer L., *Castro C.N., Schreder A., *Freitag J., Longerich T., *Lochner M., *Sparwasser T., *Berod L., Koenecke C., Prinz I. (2016) Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease European Journal of Immunology 46: 2233 - 2238. Smith K.A., Filbey K.J., Reynolds L.A., Hewitson J.P., Harcus Y., Boon L., *Sparwasser T., Hämmerling G., Maizels R.M. (2016) Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths Mucosal Immunology 9: 428 - 443. Win S.J., Kühl A.A., *Sparwasser T., Hünig T., Kamradt T. (2016) In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice European Journal of Immunology 46: 1193 - 1202. *Yang B.-H., *Hagemann S., *Mamareli P., Lauer U., Hoffmann U., *Beckstette M., Föhse L., Prinz I., *Pezoldt J., Suerbaum S., *Sparwasser T., Hamann A., *Flöss S., *Hühn J., *Lochner M. (2016) Foxp3+ T cells expressing RORϒt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation Mucosal Immunology 9: 444 - 457. Akeus P., Langenes V., Kristensen J., von Mentzer A., *Sparwasser T., Raghavan S., Quiding-Jarbrink M. (2015) Treg-cell depletion promotes chemokine production and accumulation of CXCR3+ conventional T cells in intestinal tumors European Journal of Immunology 45: 1654 - 1666. Alissafi T., Hatzioannou A., Ioannou M., *Sparwasser T., Grün J.R., Grützkau A., Verginis P. (2015) De novo-induced self-antigen-specific Foxp3+ regulatory T cells impair the accumulation of inflammatory

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dendritic cells in draining lymph nodes Journal of Immunology 194: 5812 - 5824. *Arnold-Schrauf C., *Berod L., *Sparwasser T. (2015) Dendritic cell specific targeting of MyD88 signalling pathways in vivo European Journal of Immunology 45: 32 - 39. Bolton H.A., Zhu E., Terry A.M., Guy T.V., Koh W.-P., Tan S.-Y., Power C.A., Bertolino P., Lahl K., *Sparwasser T., Shklovskaya E., De St. Groth B.F. (2015) Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease Journal of Clinical Investigation 125: 3627 - 3641. Bothur E., Raifer H., Haftmann C., Stittrich A.-B., Brustle A., Brenner D., Bollig N., Bieringer M., Kang C.-H., Reinhard K., Camara B., Huber M., Visekruna A., Steinhoff U., Repenning A., Bauer U.-M., Sexl V., Radbruch A., *Sparwasser T., Mashreghi M.-F. (2015) Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1 Nature Communications 6: 8576. *Castro C.N., *Freitag J., *Berod L., *Lochner M., *Sparwasser T. (2015) Microbe-associated immunomodulatory metabolites: Influence on T cell fate and function Molecular Immunology 68: 575 - 584. Dhainaut M., Coquerelle C., Uzureau S., Denoeud J., Acolty V., Oldenhove G., Galuppo A., *Sparwasser T., Thielemans K., Pays E., Yagita H., Borst J., Moser M. (2015) Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells EMBO Journal 34: 1336 - 1348. Khan A.R., Amu S., Saunders S.P., Hams E., Blackshields G., Leonard M.O., Weaver C.T., *Sparwasser T., Sheils O., Fallon P.G. (2015) Ligation of TLR7 on CD19+CD1dhi B cells suppresses allergic lung inflammation via regulatory T cells European Journal of Immunology 45: 1842 - 1854. Legoux F.P., Lim J.-B., Cauley A.W., Dikiy S., Ertelt J., Mariani T.J., *Sparwasser T., Way S.S., Moon J.J. (2015) CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion Immunity 43: 896 - 908. *Lochner M., *Berod L., *Sparwasser T. (2015) Fatty acid metabolism in the regulation of T cell function Trends in Immunology 36: 81 - 91. *Lochner M., *Wang Z., *Sparwasser T. (2015) The Special Relationship in the Development and Function of T Helper 17 and Regulatory T Cells Progress in Molecular Biology and Translational Science 136: 99 - 129. Mahapatra S., Albrecht M., *Baru A.M., *Sparwasser T., Herrick C., Dittrich A.M. (2015) Superior Suppressive Capacity of Skin Tregs Compared with Lung Tregs in a Model of Epicutaneous Priming Journal of Investigative Dermatology 135: 2418 - 2426. Molina M.A., Diaz A.M., *Hesse C., *Ginter W., Gentilini M.V., Nunez G.G., Canellada A.M., *Sparwasser T., *Berod L., Castro M.S., Manghi M.A. (2015) Immunostimulatory effects triggered by Enterococcus faecalis CECT7121 probiotic strain involve activation of dendritic cells and interferon-gamma production PLoS ONE 10: 127262. Niedzielska M., Raffi F.A.M., Tel J., Muench S., Jozefowski K., Alati N., Lahl K., Mages J., Billmeier U., Schiemann M., Appelt U.K., Wirtz S., *Sparwasser T., Hochrein H., Figdor C.G., Keyse S.M., Lang R. (2015) Selective expression of the MAPK phosphatase Dusp9/MKP-4 in mouse plasmacytoid dendritic cells and regulation of IFN-β production Journal of Immunology 195: 1753 - 1762.

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Schuhmann M.K., Kraft P., Stoll G., Lorenz K., Meuth S.G., Wiendl H., Nieswandt B., *Sparwasser T., Beyersdorf N., Kerkau T., Kleinschnitz C. (2015) CD28 superagonist-mediated boost of regulatory T cells increases thrombo-inflammation and ischemic neurodegeneration during the acute phase of experimental stroke Journal of Cerebral Blood Flow and Metabolism 35: 6 - 10. *Tebartz C., *Horst S.A., *Sparwasser T., *Hühn J., Beineke A., Peters G., *Medina E. (2015) A major role for myeloid-derived suppressor cells and a minor role for regulatory T cells in immunosuppression during Staphylococcus aureus infection Journal of Immunology 194: 1100 - 1111. Torow N., Yu K., Hassani K., *Freitag J., Schulz O., Basic M., *Brennecke A., *Sparwasser T., Wagner N., Bleich A., *Lochner M., *Weiss S., Forster R., Pabst O., Hornef M.W. (2015) Active suppression of intestinal CD4+TCRαβ+ T-lymphocyte maturation during the postnatal period. Nature Communications 6: 7725. Unger W.W.J., *Mayer C.T., Engels S., *Hesse C., Perdicchio M., *Puttur F., Streng-Ouwehand I., Litjens M., Kalay H., *Berod L., *Sparwasser T., van Kooyk Y. (2015) Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression OncoImmunology 4: 3p. *Yodoi K., *Yamashita T., *Sasaki N., *Kasahara K., *Emoto T., *Matsumoto T., *Kita T., *Sasaki Y., *Mizoguchi T., *Sparwasser T., *Hirata K. (2015) Foxp3+ regulatory T cells play a protective role in angiotensin II-induced aortic aneurysm formation in mice Hypertension 65: 889 - 895. *Arnold-Schrauf C., *Dudek M., *Dielmann A., Pace L., *Swallow M., *Kruse F., Kuhl A.A., Holzmann B., *Berod L., *Sparwasser T. (2014) Dendritic Cells Coordinate Innate Immunity via MyD88 Signaling to Control Listeria monocytogenes Infection Cell Reports 6: 698 - 708. *Berod L., *Stuve P., Varela F., Behrends J., *Swallow M., *Kruse F., *Krull F., *Ghorbani P., *Mayer C.T., Holscher C., *Sparwasser T. (2014) Rapid rebound of the Treg compartment in DEREG mice limits the impact of treg depletion on mycobacterial burden, but prevents autoimmunity PLoS ONE 9: e102804. *Berod L., Stuve P., *Swallow M., *Arnold-*Schrauf C., *Kruse F., *Gentilini M.V., *Freitag J., Holzmann B., *Sparwasser T. (2014) MyD88 signalling in myeloid cells is sufficient to prevent chronic mycobacterial infection European Journal of Immunology 44: 1399 - 1409. Blankenhaus B., Reitz M., Brenz Y., Eschbach M.-L., Hartmann W., Haben I., *Sparwasser T., *Hühn J., Kuhl A., Feyerabend T.B., Rodewald H.-R., Breloer M. (2014) Foxp3+ Regulatory T Cells Delay Expulsion of Intestinal Nematodes by Suppression of IL-9-Driven Mast Cell Activation in BALB/c but Not in C57BL/6 Mice PLoS Pathogens 10: e1003913. Chrobak P., Afkhami S., Priceputu E., Poudrier J., Meunier C., Hanna Z., *Sparwasser T., Jolicoeur P. (2014) HIV Nef expression favors the relative preservation of CD4+ T regulatory cells that retain some important suppressive functions Journal of Immunology 192: 1681 - 1692. Ehrlich A., Castilho T.M., Goldsmith-Pestana K., Chae W.-J., Bothwell A.L.M., *Sparwasser T., McMahon-Pratt D. (2014) The immunotherapeutic role of regulatory T cells in Leishmania (Viannia) panamensis infection Journal of Immunology 193: 2961 - 2970. Espinoza Mora M.D.R., Steeg C., Tartz S., Heussler V., *Sparwasser T., Link A., Fleischer B., Jacobs T.

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(2014) Depletion of regulatory T cells augments a vaccine-induced T effector cell response against the liver-stage of malaria but fails to increase memory PLoS ONE 9: e104627. *Ganesh V., *Baru A.M., *Hesse C., *Friedrich C., Glage S., *Gohmert M., *Janke C., *Sparwasser T. (2014) Salmonella enterica serovar typhimurium infection-induced CD11b+ Gr1+ cells ameliorate allergic airway inflammation Infection and Immunity 82: 1052 - 1063. Jost N.H., Abel S., Hutzler M., *Sparwasser T., Zimmermann A., Roers A., Muller W., Klopfleisch R., Hengel H., Westendorf A.M., Buer J., Hansen W. (2014) Regulatory T cells and T-cell-derived IL-10 interfere with effective anti-cytomegalovirus immune response Immunology and Cell Biology 92: 860 - 871. *Lindenberg M., *Solmaz G., *Puttur F., *Sparwasser T. (2014) Mouse cytomegalovirus infection overrules T regulatory cell suppression on natural killer cells Virology Journal 11: 145. Mayer C.T., *Sparwasser T. (2014) Assessing the suppressive activity of Foxp3+ regulatory T cells Methods in Molecular Biology 1193: 85 - 96. *Mayer C.T., *Ghorbani P., *Nandan A., *Dudek M., *Arnold-Schrauf C., *Hesse C., *Berod L., *Stuve P., *Puttur F., Merad M., *Sparwasser T. (2014) Selective and efficient generation of functional Batf3-dependent CD1031 dendritic cells from mouse bone marrow Blood 124: 3081 - 3091. *Mayer C.T., *Ghorbani P., Kühl A.A., *Stüve P., *Hegemann M., *Berod L., Roblegg M.E., *Sparwasser T. (2014) Few Foxp3+ regulatory T cells are sufficient to protect adult mice from lethal autoimmunity European Journal of Immunology 44: 2990 - 3002. *Mayer C.T., Lahl K., *Milanez-Almeida P., Watts D., Dittmer U., Fyhrquist N., *Hühn J., Kopf M., Kretschmer K., Rouse B., *Sparwasser T. (2014) Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice Immunity, Inflammation and Disease 2: 162 - 165. *Mayer C.T., Tian L., *Hesse C., Kuhl A.A., *Swallow M., *Kruse F., *Thiele M., Gershwin M.E., Liston A., *Sparwasser T. (2014) Anti-CD4 treatment inhibits autoimmunity in scurfy mice through theattenuation of co-stimulatory signals Journal of Autoimmunity 50: 23 - 32. Meyer Zu Horste G., Cordes S., Mausberg A.K., Zozulya A.L., Wessig C., *Sparwasser T., Mathys C., Wiendl H., Hartung H.-P., Kieseier B.C. (2014) FoxP3+ regulatory T cells determine disease severity in rodent models of inflammatory neuropathies PLoS ONE 9: e108756. Pastille E., Bardini K., Fleissner D., Adamczyk A., Frede A., Wadwa M., Von Smolinski D., Kasper S., *Sparwasser T., Gruber A.D., Schuler M., Sakaguchi S., Roers A., Muller W., Hansen W., Buer J., Westendorf A.M. (2014) Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer Cancer Research 74: 4258 - 4269. Petzold C., Steinbronn N., *Gereke M., Strasser R.H., *Sparwasser T., *Bruder D., *Geffers R., Schallenberg S., Kretschmer K. (2014) Fluorochrome-based definition of naturally occurring Foxp3+ regulatory T cells of intra- and extrathymic origin European Journal of Immunology 44: 3632 - 3645. Villalta S.A., Rosenthal W., Martinez L., Kaur A., *Sparwasser T., Tidball J.G., Margeta M., Spencer M.J., Bluestone J.A. (2014) Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy Science Translational Medicine 6: 258ra142. *Wang Z., *Friedrich C., *Hagemann S.C., *Korte W.H., *Goharani N., Cording S., Eberl G.,

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*Sparwasser T., *Lochner M. (2014) Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium Mucosal Immunology 7: 1290 - 1301. Wang Y., *Sparwasser T., Figlin R., Kim H.L. (2014) Foxp3+ T cells inhibit antitumor immune memory modulated by mTOR inhibition Cancer Research 74: 2217 - 2228. Akhmetzyanova I., Zelinskyy G., Schimmer S., Brandau S., Altenhoff P., *Sparwasser T., Dittmer U. (2013) Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells Cancer Immunology, Immunotherapy 62: 257 - 271. Chai Q., Onder L., Scandella E., Gil-Cruz C., Perez-Shibayama C., Cupovic J., Danuser R., *Sparwasser T., Luther SanjivA., Thiel V., Rulicke T., Stein JensV., Hehlgans T., Ludewig B. (2013) Maturation of Lymph Node Fibroblastic Reticular Cells from Myofibroblastic Precursors Is Critical for Antiviral Immunity Immunity 38: 1013 - 1024. Fernandez M.A., Yu U., Zhang G., White R., *Sparwasser T., Alexander S.I., Jones C.A. (2013) Treg depletion attenuates the severity of skin disease from ganglionic spread after HSV-2 flank infection Virology 447: 9 - 20. *Hesse C., *Ginter W., *Forg T., *Mayer C.T., *Baru A.M., *Arnold-Schrauf C., Unger W.W.J., Kalay H., van Kooyk Y., *Berod L., *Sparwasser T. (2013) In vivo targeting of human DC-SIGN drastically enhances CD8+ T-cell-mediated protective immunity European Journal of Immunology 43: 2543 - 2553. Hu M., Wang C., Zhang G.Y., Saito M., Wang Y.M., Fernandez M.A., Wang Y., Wu H., Hawthorne W.J., Jones C., O'Connell P.J., *Sparwasser T., Bishop G.A., Sharland A.F., Alexander S.I. (2013) Infiltrating Foxp3+ regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance American Journal of Transplantation 13: 2819 - 2830. Kanjarawi R., Dy M., Bardel E., *Sparwasser T., Dubois B., Mecheri S., Kaiserlian D. (2013) Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis. PLoS ONE 8: e69183. Klingenberg R., Gerdes N., Badeau R.M., Gistera A., Strodthoff D., Ketelhuth D.F.J., Lundberg A.M., Rudling M., Nilsson S.K., Olivecrona G., Zoller S., Lohmann C., Luscher T.F., Jauhiainen M., *Sparwasser T., Hansson G.K. (2013) Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis Journal of Clinical Investigation 123: 1323 - 1334. Kuhlhorn F., Rath M., Schmoeckel K., Cziupka K., Nguyen H.H., Hildebrandt P., Hunig T., *Sparwasser T., *Hühn J., Potschke C., Broker B.M. (2013) Foxp3+ Regulatory T Cells Are Required for Recovery from Severe Sepsis PLoS ONE 8: e65109. Layland L.E., Straubinger K., Ritter M., Loffredo-Verde E., Garn H., *Sparwasser T., Prazeres da Costa C. (2013) Schistosoma mansoni-Mediated Suppression of Allergic Airway Inflammation Requires Patency and Foxp3+ Treg Cells PLoS Neglected Tropical Diseases 7: e2379. Martin B., Auffray C., Delpoux A., Pommier A., Durand A., Charvet C., Yakonowsky P., De Boysson H., Bonilla N., Audemard A., *Sparwasser T., Salomon B.L., Malissen B., Lucas B. (2013) Highly self-reactive naive CD4 T cells are prone to differentiate into regulatory T cells Nature Communications 4: 3209. *Mayer C.T., *Huntenburg J., *Nandan A., Schmitt E., *Czeloth N., *Sparwasser T. (2013) CD4 blockade directly inhibits mouse and human CD4+ T cell functions independent of FoxP3+ Tregs

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Journal of Autoimmunity 47: 73 - 82. Pasquet L., Douet J.Y., *Sparwasser T., Romagnoli P., van Meerwijk J.P. (2013) Long-term prevention of chronic allograft rejection by regulatory T-cell immunotherapy involves host FoxP3-expressing T cells. Blood 121: 4303 - 4310. Petzold C., Riewaldt J., Watts D., *Sparwasser T., Schallenberg S., Kretschmer K. (2013) Foxp3+ regulatory T cells in mouse models of type 1 diabetes Journal of Diabetes Research 2013: 940710. *Puttur F., *Arnold-Schrauf C., Lahl K., *Solmaz G., *Lindenberg M., *Mayer C.T., *Gohmert M., *Swallow M., *van Helt C., Schmitt H., Nitschke L., Lambrecht B.N., Lang R., Messerle M., *Sparwasser T. (2013) Absence of Siglec-H in MCMV Infection Elevates Interferon Alpha Production but Does Not Enhance Viral Clearance PLoS Pathogens 9: e1003648. Rosalia R.A., Stepanek I., Pollakova V., Simova J., Bieblova J., Indrova M., Moravcova S., Pribylova H., Bontkes H.J., Bubenik J., *Sparwasser T., Reinis M. (2013) Administration of anti-CD25 mAb leads to impaired alpha-galactosylceramide-mediated induction of IFN-gamma production in a murine model Immunobiology 218: 851 - 859. Schmitz I., Schneider C., Frohlich A., Frebel H., Christ D., Leonard W.J., *Sparwasser T., Oxenius A., Freigang S., Kopf M. (2013) IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection PLoS Pathogens 9: e1003362. Worthington J.J., Klementowicz J.E., Rahman S., Czajkowska B.I., Smedley C., Waldmann H., *Sparwasser T., Grencis R.K., Travis M.A. (2013) Loss of the TGFβ-Activating Integrin αvβ8 on Dendritic Cells Protects Mice from Chronic Intestinal Parasitic Infection via Control of Type 2 Immunity PLoS Pathogens 9: e1003675.

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Lucas S., Omata Y, Hofmann J., Böttcher M., *Iljazovic A., Sarter K., Albrecht O., Schulz O., Krishnacoumar B., Krönke G., Herrmann M., Mougiakakos D., *Strowig T., Schett G., Zaiss M.M. (2018) Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss Nature Communications 9: 55. *Blazejewski A.J., *Thiemann S., Schenk A., *Pils M.C., *Gálvez E.J.C., *Roy U., *Heise U., de Zoete M.R., Flavell R.A., *Strowig T. (2017) Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation Cell Reports 19: 2319 - 2330. *Fabiani F.D., *Renault T.T., Peters B., Dietsche T., *Gálvez E.J.C., *Guse A., *Freier K., Charpentier E., *Strowig T., Franz-Wachtel M., Macek B., Wagner S., Hensel M., *Erhardt M. (2017) A flagellum-specific chaperone facilitates assembly of the core type III export apparatus of the bacterial flagellum PLoS Biology 15: e2002267. *Friedrich C., *Mamareli P., *Thiemann S., *Kruse F., *Wang Z., Holzmann B., *Strowig T., *Sparwasser T., *Lochner M. (2017) MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium PLoS Pathogens 13: e1006357. *Gálvez E.J.C, *Iljazovic A., *Gronow A., Flavell R., *Strowig T. (2017) Shaping of Intestinal Microbiota in Nlrp6- and Rag2-Deficient Mice Depends on Community Structure Cell Reports 21: 3914 - 3926. Herndler-Brandstetter D., Shan L., Yao Y., Stecher C., Plajer V., Lietzenmayer M., *Strowig T., De Zoete M.R., Palm N.W., Chen J., Blish C.A., Frleta D., Gurer C., Macdonald L.E., Murphy A.J., Yancopoulos G.D., Montgomery R.R., Flavell R.A. (2017) Humanized mouse model supports development, function, and tissue residency of human natural killer cells Proceedings of the National Academy of Sciences of the United States of America 114: E9626 - E9634. *Horstmann J.A., *Zschieschang E., Truschel T., *de Diego J., *Lunelli M., *Rohde M., May T., *Strowig T., *Stradal T., *Kolbe M., *Erhardt M. (2017) Flagellin phase-dependent swimming on epithelial cell surfaces contributes to productive Salmonella gut colonisation Cellular Microbiology 19: e12739. *Roy U, *Galvez EJC, *Iljazovic A, *Lesker T, *Blazejewski A, * Pils M, *Heise U, Huber S, Flavell RA, *Strowig T. (2017) Distinct microbial communities trigger colitis development upon damage to the intestinal barrier via innate or adaptive immune cells. Cell Reports 21:994-1008. *Rueckert C., *Rand U., *Roy U., *Kasmapour B., *Strowig T., *Guzmán C.A. (2017) Cyclic dinucleotides modulate induced type i IFN responses in innate immune cells by degradation of STING FASEB Journal 31: 3107 - 3115. *Thiemann S., *Smit N., *Roy U., *Lesker T.R., *Gálvez E.J.C., *Helmecke J., Basic M., Bleich A., Goodman A.L., *Kalinke U., Flavell R.A., *Erhardt M., *Strowig T. (2017) Enhancement of IFNγProduction by Distinct Commensals Ameliorates Salmonella-Induced Disease Cell Host and Microbe 21: 682 - 694.e5. Yu H., Borsotti C., Schickel J.-N., Zhu S., *Strowig T., Eynon E.E., Frleta D., Gurer C., Murphy A.J., Yancopoulos G.D., Meffre E., Manz M.G., Flavell R.A. (2017) A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production Blood 129: 959 - 969. Hu B., Jin C., Li H.-B., Tong J., Ouyang X., Cetinbas N.M., Zhu S., *Strowig T., Lam F.C., Zhao C., Henao-

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Mejia J., Yilmaz O., Fitzgerald K.A., Eisenbarth S.C., Elinav E., Flavell R.A. (2016) The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury Science 354: 765 - 768. Pelczar P, Witkowski M, Perez LG, Kempski J, Hammel AG, Brockmann L, Kleinschmidt D, Wende S, Haueis C, Bedke T, Witkowski M, Krasemann S, Steurer S, Booth CJ, Busch P, König A, Rauch U, Benten D, Izbicki JR, Rösch T, Lohse AW, *Strowig T, Gagliani N, Flavell RA, Huber S. (2016) A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease. Science 354: 358-362. Rausch P., Basic M., Batra A., Bischoff S.C., Blaut M., Clavel T., Gläsner J., Gopalakrishnan S., Grassl G.A., Günther C., Haller D., Hirose M., Ibrahim S., Loh G., Mattner J., Nagel S., Pabst O., Schmidt F., Siegmund B., *Strowig T., Volynets V., Wirtz S (2016) Analysis of factors contributing to variation in the C57BL/6J fecal microbiota across German animal facilities International Journal of Medical Microbiology 306: 343 - 355. *Thiemann S., *Smit N., *Strowig T. (2016) Antibiotics and the intestinal microbiome: Individual responses, resilience of the ecosystem, and the susceptibility to infections Current Topics in Microbiology and Immunology 398: 123 - 146. Finethy R., Jorgensen I., Haldar A.K., de Zoete M.R., *Strowig T., Flavell R.A., Yamamoto M., Nagarajan U.M., Miao E.A., Coers J. (2015) Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages Infection and Immunity 83: 4740 - 4749. Wynosky-Dolfi M.A., Snyder A.G., Philip N.H., Doonan P.J., Poffenberger M.C., Avizonis D., Zwack E.E., Riblett A.M., Hu B., *Strowig T., Flavell R.A., Jones R.G., Freedman B.D., Brodsky I.E. (2014) Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome Journal of Experimental Medicine 211: 653 - 668.

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model for biopolymer production Chemical and Biochemical Engineering Quarterly 31: 89 - 99.

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modeling and simulation to evaluate treatment strategies against influenza-pneumococcus

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*Duvigneau S., *Sharma-Chawla N., *Boianelli A., *Stegemann-Koniszewski S., *Nguyen V.K., *Bruder

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influenza susceptibility to pneumococcal coinfection Scientific Reports 6: 37045.

*Nguyen V.K., *Klawonn F., *Mikolajczyk R., *Hernandez-Vargas E.A. (2016) Analysis of practical

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Applied Soft Computing Journal 24: 1175 - 1182.

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determine when to initiate and alternate therapy in HIV infection BioMed Research International

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M.C., Krzysiek R., Merad M., Seng R., Tardieu M., Delfraissy J.F., Goujard C., Taoufik Y. (2014)

Progressive contraction of the latent HIV reservoir around a core of less-differentiated CD4+ memory

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simplified HIV infection model Automatica 49: 2874 - 2880.

*Hernandez-Vargas E.A., Middleton R.H. (2013) Modeling the three stages in HIV infection Journal of

Theoretical Biology 320: 33 - 40.

*Schmeitz C., *Hernandez-Vargas E.A., Fliegert R., Guse A.H., *Meyer-Hermann M. (2013) A

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*Felgner S., *Kocijancic D., *Frahm M., *Heise U., *Rohde M., Zimmermann K., Falk C., *Erhardt M., *Weiss S. (2018) Engineered Salmonella enterica serovar Typhimurium overcomes limitations of anti-bacterial immunity in bacteria-mediated tumor therapy OncoImmunology 7: e1382791. Fischer J.C., Bscheider M., Eisenkolb G., Lin C.-C., Wintges A., Otten V., Lindemans C.A., Heidegger S., Rudelius M., Monette S., Rodriguez K.A.P., Calafiore M., Liebermann S., Liu C., *Lienenklaus S., Weiss S., Kalinke U., Ruland J., Peschel C., Shono Y. (2017) RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury Science Translational Medicine 9: eaag2513. *Hatzikirou H., *Alfonso J.C.L., *Leschner S., *Weiss S., *Meyer-Hermann M. (2017) Therapeutic potential of bacteria against solid tumors Cancer Research 77: 1553 - 1563. *Kocijancic D, *Leschner S, *Felgner S, *Komoll RM, *Frahm M, *Pawar V, *Weiss S. (2017) Therapeutic benefit of Salmonella attributed to LPS and TNF-a is exhaustible and dictated by tumor susceptibility Oncotarget 8: 36492 - 36508. *Kocijancic D., *Felgner S., *Schauer T., *Frahm M., *Heise U., Zimmermann K., *Erhardt M., *Weiss S. (2017) Local application of bacteria improves safety of Salmonella-mediated tumor therapy and retains advantages of systemic infection Oncotarget 8: 49988 - 50001. Kreslavsky T, Vilagos B, Tagoh H, Poliakova DK, Schwickert TA, Wöhner M, Jaritz M, *Weiss S, Taneja R, Rossner MJ, Busslinger M. (2017) Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells Nature Immunology 18: 442 - 455. Ruangkiattikul N., Nerlich A., *Abdissa K., *Lienenklaus S., *Suwandi A., Janze N., Laarmann K., *Spanier J., *Kalinke U., *Weiss S., Goethe R. (2017) cGAS-STING-TBK1-IRF3/7 induced interferon-ß contributes to the clearing of non tuberculous mycobacterial infection in mice Virulence 8: 1303 - 1315. *Suwandi A., *Bargen I., *Pils M.C., *Krey M., *Lage S.Z., Singh A.K., Basler T., Falk C.S., Seidler U., Hornef M.W., Goethe R., *Weiss S. (2017) CD4 T Cell dependent colitis exacerbation following Re-Exposure of Mycobacterium avium ssp. paratuberculosis Frontiers in Cellular and Infection Microbiology 7: 75. Tata M., Amman F., *Pawar V., Wolfinger M.T., *Weiss S., *Häussler S., Bläsi U. (2017) The anaerobically induced sRNA PaiI affects denitrification in Pseudomonas aeruginosa PA14 Frontiers in Microbiology 8: 2312. *Ziegler A., *Soldner C., *Lienenklaus S., *Spanier J., *Trittel S., *Riese P., Kramps T., *Weiss S., Heidenreich R., Jasny E., *Guzmán C.A., Kallen K.-J., Fotin-Mleczek M., *Kalinke U. (2017) A new RNA-based adjuvant enhances virus-specific vaccine responses by locally triggering TLR- and RLH-dependent effects Journal of Immunology 198: 1595 - 1605. *Andzinski L., *Kasnitz N., *Stahnke S., *Wu C.-F., *Gereke M., Von Köckritz-Blickwede M., Schilling B., Brandau S., *Weiss S., *Jablonska J. (2016) Type i IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human International Journal of Cancer 138: 1982 - 1993. *Andzinski L., *Spanier J., *Kasnitz N., *Kröger A., Jin L., *Brinkmann M.M., *Kalinke U., *Weiss S., *Jablonska J., *Lienenklaus S. (2016) Growing tumors induce a local STING dependent Type I IFN response in dendritic cells International Journal of Cancer 139: 1350 - 1357.

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Blume J., *Zur Lage S., Witzlau K., Georgiev H., *Weiss S., Lyszkiewicz M., Zietara N., Krueger A. (2016) Overexpression of Va14Ja18 TCR promotes development of iNKT cells in the absence of miR-181a/b-1 Immunology and Cell Biology 94: 741 - 746. *Casilag F., *Lorenz A., *Krueger J., *Klawonn F., *Weiss S., *Häussler S. (2016) LasB elastase of Pseudomonas aeruginosa acts in concert with alkaline protease AprA to prevent flagellin-mediated immune recognition Infection and Immunity 84: 162 - 171. Castiglia V., Piersigilli A., Ebner F., Janos M., *Goldmann O., Damböck U., *Kröger A., *Weiss S., Knapp S., Jamieson A.M., Kirschning C., *Kalinke U., Strobl B., Müller M., Stoiber D., Lienenklaus S., Kovarik P. (2016) Type I Interferon Signaling Prevents IL-1ß-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue Cell Host and Microbe 19: 375 - 387. De Beuckelaer A., Pollard C., Van Lint S., Roose K., Van Hoecke L., Naessens T., Udhayakumar V.K., Smet M., Sanders N., *Lienenklaus S., Saelens X., *Weiss S., Vanham G., Grooten J., De Koker S. (2016) Type I interferons interfere with the capacity of mRNA lipoplex vaccines to elicit Cytolytic T cell responses Molecular Therapy 24: 2012 - 2020. *Deyneko I.V., *Kasnitz N., *Leschner S., *Weiss S. (2016) Composing a tumor specific bacterial promoter PLoS ONE 11: e0155338. *Felgner S., *Frahm M., *Kocijancic D., *Rohde M., *Eckweiler D., *Bielecka A., Bueno E., Cava F., *Abraham W.-R., Curtiss R., III, *Häussler S., *Erhardt M., *Weiss S. (2016) Aroa-deficient Salmonella enterica serovar Typhimurium is more than a metabolically attenuated mutant mBio 7: e01220-16. *Felgner S., *Kocijancic D., *Frahm M., *Weiss S. (2016) Bacteria in cancer therapy: Renaissance of an old concept International Journal of Microbiology 2016: 8451728. *Felgner S., *Kocijancic D., *Frahm M., Curtiss R., 3rd, *Erhardt M., *Weiss S. (2016) Optimizing Salmonella enterica serovar Typhimurium for bacteria-mediated tumor therapy Gut microbes 7: 171 - 177. *Felgner S., *Kocijancic D., *Pawar V., *Weiss S. (2016) Biomimetic Salmonella: A Next-Generation Therapeutic Vector? Trends in Microbiology 24: 850 - 852. Grine L., Steeland S., Van Ryckeghem S., Ballegeer M., *Lienenklaus S., *Weiss S., Sanders N.N., Vandenbroucke R.E., Libert C. (2016) Topical imiquimod yields systemic effects due to unintended oral uptake Scientific Reports 6: 20134. *Kocijancic D., *Felgner S., *Frahm M., *Komoll R.-M., *Iljazovic A., *Pawar V., *Rohde M., Heise U., Zimmermann K., Gunzer F., *Hammer J., *Crull K., *Leschner S., *Weiss S. (2016) Therapy of solid tumors using probiotic Symbioflor-2-restraints and potential Oncotarget 7: 22605 - 22622. *Kühn N., Bergmann S., *Kösterke N., *Lambertz R.L.O., Keppner A., Van Den Brand J.M.A., Pöhlmann S., *Weiß S., Hummler E., *Hatesuer B., *Schughart K. (2016) The proteolytic activation of (H3N2) influenza A virus hemagglutinin is facilitated by different type II transmembrane serine proteases Journal of Virology 90: 4298 - 4307. *Leschner S., *Weiss S. (2016) Noninvasive in vivo imaging to follow bacteria engaged in cancer therapy Methods in Molecular Biology 1409: 61 - 68.

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*Lorenz A., *Pawar V., *Häussler S., *Weiss S. (2016) Insights into host-pathogen interactions from state-of-the-art animal models of respiratory Pseudomonas aeruginosa infections FEBS Letters 590: 3941 - 3959. Nocera D.A., Roselli E., Araya P., Nuñez N.G., *Lienenklaus S., *Jablonska J., *Weiss S., Gatti G., *Brinkmann M.M., *Kröger A., Morón G., Maccioni M. (2016) In vivo visualizing the IFN-ß response required for tumor growth control in a therapeutic model of polyadenylic-polyuridylic acid administration Journal of Immunology 196: 2860 - 2869. *Andzinski L., *Wu C.-F., *Lienenklaus S., *Kröger A., *Weiss S., *Jablonska J. (2015) Delayed apoptosis of tumor associated neutrophils in the absence of endogenous IFN-ß International Journal of Cancer 136: 572 - 583. *Deditius J.A., *Felgner S., *Spöring I., *Kühne C., *Frahm M., *Rohde M., *Weiß S., *Erhardt M. (2015) Characterization of novel factors involved in swimming and swarming motility in Salmonella enterica serovar typhimurium PLoS ONE 10: e0135351. *Detje C.N., *Lienenklaus S., *Chhatbar C., *Spanier J., Prajeeth C.K., *Soldner C., Tovey M.G., *Schlüter D., *Weiss S., Stangel M., *Kalinke U. (2015) Upon intranasal vesicular stomatitis virus infection, astrocytes in the olfactory bulb are important interferon beta producers that protect from lethal encephalitis Journal of Virology 89: 2731 - 2738. Eckelt E., Meissner T., Meens J., Laarmann K., Nerlich A., *Jarek M., *Weiss S., Gerlach G.-F., Goethe R. (2015) FurA contributes to the oxidative stress response regulation of Mycobacterium avium ssp. paratuberculosis Frontiers in Microbiology 6: 16. *Frahm M., *Felgner S., *Kocijancic D., *Rohde M., Hensel M., Curtiss I.R., *Erhardt M., *Weiss S. (2015) Efficiency of conditionally attenuated Salmonella enterica serovar typhimurium in bacterium-mediated tumor therapy mBio 6: 1 - 11. Hartlova A., Erttmann S.F., Raffi F.A.M., Schmalz A.M., Resch U., Anugula S., *Lienenklaus S., Nilsson L.M., *Kroger A., Nilsson J.A., Ek T., *Weiss S., Gekara N.O. (2015) DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity Immunity 42: 332 - 343. *Hatzikirou H., Alfonso J.C., *Mühle S., *Stern C., *Weiss S., *Meyer-Hermann M. (2015) Cancer therapeutic potential of combinatorial immuno- and vasomodulatory interventions Journal of the Royal Society Interface 12: 20150439. Kashani E., Fohse L., Raha S., Sandrock I., Oberdorfer L., Koenecke C., Suerbaum S., *Weiss S., Prinz I. (2015) A clonotypic Vγ4Jγ1/Vδ5Dδ2Jδ1 innate γδ T-cell population restricted to the CCR6+CD27- subset Nature Communications 6: 6477. Khorooshi R., Morch M.T., Holm T.H., Berg C.T., Dieu R.T., Draeby D., Issazadeh-Navikas S., *Weiss S., *Lienenklaus S., Owens T. (2015) Induction of endogenous Type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis Acta Neuropathologica 130: 107 - 118. *Pawar V., *Komor U., *Kasnitz N., *Bielecki P., *Pils M.C., Gocht B., Moter A., *Rohde M., *Weiss S., *Haussler S. (2015) In vivo efficacy of antimicrobials against biofilm-producing Pseudomonas aeruginosa Antimicrobial Agents and Chemotherapy 59: 4974 - 4981.

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*Pustelny C., *Komor U., *Pawar V., *Lorenz A., *Bielecka A., Moter A., Gocht B., *Eckweiler D., *Musken M., Grothe C., *Lunsdorf H., *Weiss S., *Haussler S. (2015) Contribution of Veillonella parvula to Pseudomonas aeruginosa-mediated pathogenicity in a murine tumor model system Infection and Immunity 83: 417 - 429. *Rais B., *Rahim M.I., *Lienenklaus S., *Weiss S., Tolle C., Seitz J.-M., Menzel H., *Hauser H., *Müller P.P. (2015) Animal test models for implant-associated inflammation and infections Lecture Notes in Applied and Computational Mechanics 74: 175 - 187. *Stern C., *Kasnitz N., *Kocijancic D., *Trittel S., *Riese P., *Guzmán C.A., *Leschner S., *Weiss S. (2015) Induction of CD4+ and CD8+ anti-tumor effector T cell responses by bacteria mediated tumor therapy International Journal of Cancer 137: 2019 - 2028. Torow N., Yu K., Hassani K., *Freitag J., Schulz O., Basic M., *Brennecke A., *Sparwasser T., Wagner N., Bleich A., *Lochner M., *Weiss S., Forster R., Pabst O., Hornef M.W. (2015) Active suppression of intestinal CD4+TCRαβ+ T-lymphocyte maturation during the postnatal period. Nature Communications 6: 7725. *Wu C.-F., *Andzinski L., *Kasnitz N., *Kröger A., *Klawonn F., *Lienenklaus S., *Weiss S., *Jablonska J. (2015) The lack of type I interferon induces neutrophil-mediated pre-metastatic niche formation in the mouse lung International Journal of Cancer 137: 837 - 847. Atreya R., Bulte M., Gerlach G.-F., Goethe R., Hornef M.W., Kohler H., Meens J., Mobius P., Roeb E., *Weiss S. (2014) Facts, myths and hypotheses on the zoonotic nature of Mycobacterium avium subspecies paratuberculosis International Journal of Medical Microbiology 304: 858 - 867. Basic M., Keubler L.M., Buettner M., Achard M., Breves G., Schröder B., Smoczek A., Jörns A., Wedekind D., Zschemisch N.H., Günther C., Neumann D., *Lienenklaus S., *Weiss S., Hornef M.W., Mähler M., Bleich A. (2014) Norovirus triggered microbiota-driven mucosal inflammation in interleukin 10-deficient mice Inflammatory Bowel Diseases 20: 431 - 443. *Dag F., Dolken L., *Holzki J., *Drabig A., *Weingartner A., *Schwerk J., *Lienenklaus S., *Conte I., *Geffers R., Davenport C., *Rand U., *Köster M., *Weiss S., Adler B., *Wirth D., Messerle M., *Hauser H., *Cicin-Sain L. (2014) Reversible Silencing of Cytomegalovirus Genomes by Type I Interferon Governs Virus Latency PLoS Pathogens 10: e1003962. *Doring M., *Lessin I., *Frenz T., *Spanier J., *Kessler A., *Tegtmeyer P., *Dag F., Thiel N., Trilling M., *Lienenklaus S., *Weiss S., Scheu S., Messerle M., *Cicin-Sain L., Hengel H., *Kalinke U. (2014) M27 Expressed by cytomegalovirus counteracts effective Type I interferon induction of myeloid cells but not of plasmacytoid dendritic cells Journal of Virology 88: 13638 - 13650. *Jablonska J., *Wu C.-F., *Andzinski L., *Leschner S., *Weiss S. (2014) CXCR2-mediated tumor-associated neutrophil recruitment is regulated by IFN-? International Journal of Cancer 134: 1346 - 1358. Koc A., *Bargen I., *Suwandi A., Roderfeld M., Tschuschner A., Rath T., Gerlach G.F., Hornef M., Goethe R., *Weiss S., Roeb E. (2014) Systemic and mucosal immune reactivity upon Mycobacterium avium ssp. paratuberculosis infection in mice PLoS ONE 9: e94624. Meißner T., Eckelt E., Basler T., Meens J., Heinzmann J., *Suwandi A., Oelemann W.M., Trenkamp S., Holst O., *Weiss S., Bunk B., Spröer C., Gerlach G.F., Goethe R. (2014) The Mycobacterium avium ssp.

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paratuberculosis specific mptD gene is required for maintenance of the metabolic homeostasis necessary for full virulence in mouse infections Frontiers in Cellular and Infection Microbiology 4: 110. *Pawar V., *Crull K., *Komor U., *Kasnitz N., *Frahm M., *Kocijancic D., *Westphal K., *Leschner S., *Wolf K., *Lössner H., *Rohde M., *Häussler S., *Weiss S. (2014) Murine solid tumours as a novel model to study bacterial biofilm formation in vivo Journal of Internal Medicine 276: 130 - 139. *Skrnjug I., *Rueckert C., *Libanova R., *Lienenklaus S., *Weiss S., *Guzmán C.A. (2014) The mucosal adjuvant cyclic di-AMP exerts immune stimulatory effects on dendritic cells and macrophages PLoS ONE 9: e95728. *Spanier J., *Lienenklaus S., *Paijo J., *Kessler A., *Borst K., *Heindorf S., Baker D.P., *Kröger A., *Weiss S., *Detje C.N., Stäheli P., *Kalinke U. (2014) Concomitant TLR/RLH signaling of radioresistant and radiosensitive cells is essential for protection against vesicular stomatitis virus infection Journal of immunology 193: 3045 - 3054. *Suwandi A., *Bargen I., *Roy B., *Pils M.C., *Krey M., *Zur Lage S., Basler T., *Rohde M., Falk C.S., Hornef M.W., Goethe R., *Weiss S. (2014) Experimental colitis is exacerbated by concomitant infection with mycobacterium avium ssp. paratuberculosis Inflammatory Bowel Diseases 20: 1962 - 1971. *Tantawy M.A., *Hatesuer B., *Wilk E., *Dengler L., *Kasnitz N., *Weiss S., *Schughart K. (2014) The interferon-induced gene Ifi27l2a is active in lung macrophages and lymphocytes after Influenza A infection but deletion of Ifi27l2a in mice does not increase susceptibility to infection PLoS ONE 9: e106392. Weber E., *Finsterbusch K., Lindquist R., *Nair S., *Lienenklaus S., Gekara N.O., Janik D., *Weiss S., *Kalinke U., Overby A.K., *Kröger A (2014) Type I interferon protects mice from fatal neurotropic infection with langat virus by systemic and local antiviral responses Journal of Virology 88: 12202 - 12212. Zhang K., Dupont A., Torow N., Gohde F., *Leschner S., *Lienenklaus S., *Weiss S., *Brinkmann M.M., Kuhnel M., Hensel M., Fulde M., Hornef M.W. (2014) Age-Dependent Enterocyte Invasion and Microcolony Formation by Salmonella PLoS Pathogens 10: 16p. *Zietara N., *Lyszkiewicz M., Krueger A., *Weiss S. (2014) B-cell modulation of dendritic-cell function: Signals from the far side European Journal of Immunology 44: 23 - 32. Behrendt R., Schumann T., Gerbaulet A., Nguyen L.A., Schubert N., Alexopoulou D., Berka U., *Lienenklaus S., Peschke K., Gibbert K., Wittmann S., Lindemann D., *Weiss S., Dahl A., Naumann R., Dittmer U., Kim B., Mueller W., Gramberg T., Roers A. (2013) Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response Cell Reports 4: 689 - 696. *Bergmann S., Beard P.M., *Pasche B., *Lienenklaus S., *Weiss S., Gahan C.G.M., *Schughart K., Lengeling A. (2013) Influence of internalin a murinisation on host resistance to orally acquired listeriosis in mice BMC Microbiology 13: 90. *Bielecki P., *Komor U., *Bielecka A., *Musken M., *Puchalka J., Pletz M.W., Ballmann M., *Martins dos Santos V.A., *Weiss S., *Häussler S. (2013) Ex vivo transcriptional profiling reveals a common set of genes important for the adaptation of Pseudomonas aeruginosa to chronically infected host sites Environmental Microbiology 15: 570 - 587.

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*Deyneko I.V., Kel A.E., Kel-Margoulis O.V., Deineko E.V., Wingender E., *Weiss S. (2013) MatrixCatch - a novel tool for the recognition of composite regulatory elements in promoters BMC Bioinformatics 14: 241. Kallfass C., Stäheli P., *Lienenklaus S., *Weiss S. (2013) Visualizing the beta interferon response in mice during infection with influenza a viruses expressing or lacking nonstructural protein 1 Journal of Virology 87: 6925 - 6930. *Roy B., *Agarwal S., *Brennecke A.-M., *Krey M., Pabst O., *Duber S., *Weiss S. (2013) B-1-cell subpopulations contribute differently to gut immunity European Journal of Immunology 43: 2023 - 2032. *Roy B., *Brennecke A.-M., *Agarwal S., *Krey M., *Duber S., *Weiss S. (2013) An intrinsic propensity of murine peritoneal B1b cells to switch to IgA in presence of TGF-? and retinoic acid PLoS ONE 8: e82121. *Scheibe E., *Lienenklaus S., *May T., *Magalhaes V.G., *Weiss S., *Brinkmann M.M. (2013) Measurement of mouse cytomegalovirus-induced interferon-β with immortalized luciferase reporter cells Methods in Molecular Biology 1064: 355 - 366. *Toker A., Engelbert D., Garg G., *Polansky J.K., *Flöss S., Miyao T., Baron U., *Duber S., *Geffers R., Giehr P., Schallenberg S., Kretschmer K., Olek S., Walter J., *Weiss S., Hori S., Hamann A., *Hühn J. (2013) Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus Journal of Immunology 190: 3180 - 3188. *Viegas N., *Andzinski L., *Wu C.-F., *Komoll R.-M., *Gekara N., *Dittmar K.E., *Weiss S., *Jablonska J. (2013) IFN-γ production by CD27+ NK cells exacerbates Listeria monocytogenes infection in mice by inhibiting granulocyte mobilization European Journal of Immunology 43: 2626 - 2637. *Zietara N., *Lyszkiewicz M., *Puchalka J., *Pei G., *Gutierrez M.G., *Lienenklaus S., Hobeika E., Reth M., *Dos Santos V.A.P.M., Krueger A., *Weiss S. (2013) Immunoglobulins drive terminal maturation of splenic dendritic cells Proceedings of the National Academy of Sciences of the United States of America 110: 2282 - 2287. *Zietara N., *Lyszkiewicz M., Witzlau K., Naumann R., Hurwitz R., Langemeier J., Bohne J., Sandrock I., Ballmaier M., *Weiss S., Prinz I., Krueger A. (2013) Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells Proceedings of the National Academy of Sciences of the United States of America 110: 7407 - 7412.

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Wirth, Dagmar

*Lipps C., *Klein F., *Wahlicht T., Seiffert V., *Butueva M., Zauers J., *Truschel T., *Luckner M.,

*Köster M., MacLeod R., *Pezoldt J., *Hühn J., *Yuan O., *Müller P.P., Kempf H., Zweigerdt R.,

Dittrich-Breiholz O., Pufe T., Beckmann R., Drescher W., Riancho J., Sañudo C., Korff T., Opalka B.,

Rebmann V., Göthert J.R., Alves P.M., Ott M., Schucht R., *Hauser H., *Wirth D., *May T. (2018)

Expansion of functional, personalized cells with specific transgene combinations Nature

Communications Accepted for publication.

*Bhushal S., *Wolfsmüller M., *Selvakumar T.A., *Kemper L., *Wirth D., Hornef M.W., *Hauser H.,

*Köster M. (2017) Cell polarization and epigenetic status shape the heterogeneous response to type

III interferons in intestinal epithelial cells Frontiers in Immunology 8: 671.

*Cebula M., *Riehn M., *Hillebrand U., Kratzer R.F., Kreppel F., Koutsoumpli G., Daemen T., *Hauser

H., *Wirth D. (2017) TLR9-mediated conditioning of liver environment Is essential for successful

intrahepatic immunotherapy and effective memory recall Molecular Therapy 25: 2289 - 2298.

*Gaur P., *Cebula M., *Riehn M., *Hillebrand U., *Hauser H., *Wirth D. (2017) Diet induced obesity

has an influence on intrahepatic T cell responses Metabolism: Clinical and Experimental 69: 171 -

176.

*Gödecke N., *Zha L., *Spencer S., *Behme S., *Riemer P., Rehli M., *Hauser H., *Wirth D. (2017)

Controlled re-activation of epigenetically silenced Tet promoter-driven transgene expression by

targeted demethylation Nucleic Acids Research 45: e147.

Kunkiel J., *Gödecke N., Ackermann M., Hoffmann D., Schambach A., Lachmann N., *Wirth D., Moritz

T. (2017) The CpG-sites of the CBX3 ubiquitous chromatin opening element are critical structural

determinants for the anti-silencing function Scientific Reports 7: 7919.

*Lipps C., *Badar M., *Butueva M., *Dubich T., Singh V.V., Rau S., Weber A., Kracht M., *Köster M.,

May T., Schulz T.F., *Hauser H., *Wirth D. (2017) Proliferation status defines functional properties of

endothelial cells Cellular and Molecular Life Sciences 74: 1319 – 1333.

*Pasztoi M., *Pezoldt J., *Beckstette M., *Lipps C., *Wirth D., *Rohde M., Paloczi K., Buzas E.I.,

*Hühn J. (2017) Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to

peripheral de novo induction of Foxp3+ regulatory T cells European Journal of Immunology 47: 2142 -

2152.

Pieters T., Haenebalcke L., Bruneel K., Vandamme N., Hochepied T., Van Hengel J., *Wirth D., Berx G.,

Haigh J.J., Van Roy F., Goossens S. (2017) Structure-function studies in mouse embryonic stem cells

using recombinase-mediated cassette exchange Journal of Visualized Experiments 2017: e55575.

*Riehn M., *Cebula M., *Hauser H., *Wirth D. (2017) CpG-ODN facilitates effective intratracheal

immunization and recall of memory against neoantigen-expressing alveolar cells Frontiers in

Immunology 8: 1201.

*Selvakumar T.A., *Bhushal S., *Kalinke U., *Wirth D., *Hauser H., *Köster M., Hornef M.W. (2017)

Identification of a predominantly interferon-λ-induced transcriptional profile in murine intestinal

epithelial cells Frontiers in Immunology 8: 1302.

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Strandt H., Pinheiro D.F., Kaplan D.H., *Wirth D., Gratz I.K., Hammerl P., Thalhamer J., Stoecklinger A.

(2017) Neoantigen expression in steady-state Langerhans cells induces CTL tolerance Journal of

Immunology 199: 1626 - 1634.

*Zhao G., *Wirth D., *Schmitz I., *Meyer-Hermann M. (2017) A mathematical model of the impact of

insulin secretion dynamics on selective hepatic insulin resistance Nature Communications 8: 1362.

Bachmann M., Breitwieser T., *Lipps C., *Wirth D., Jordan I., Reichl U., Frensing T. (2016) Impaired

antiviral response of adenovirus-transformed cell lines supports virus replication Journal of General

Virology 97: 293 - 298.

*Kuehn A., *Kletting S., *De Souza Carvalho-Wodarz C., Repnik U., Griffiths G., Fischer U., Meese E., Huwer H., *Wirth D., May T., *Schneider-Daum N., *Lehr C.-M. (2016) Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier Altex 33: 251 - 260. Lempp F.A., Mutz P., *Lipps C., *Wirth D., Bartenschlager R., Urban S. (2016) Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor Journal of Hepatology 64: 556 - 564. *Ochel A., *Cebula M., *Riehn M., *Hillebrand U., *Lipps C., Schirmbeck R., *Hauser H., *Wirth D. (2016) Effective intrahepatic CD8+ T-cell immune responses are induced by low but not high numbers of antigen-expressing hepatocytes Cellular and Molecular Immunology 13: 805 - 815. Pieters T., Goossens S., Haenebalcke L., Andries V., Stryjewska A., De Rycke R., Lemeire K., Hochepied T., Huylebroeck D., Berx G., Stemmler M.P., *Wirth D., Haigh J.J., van Hengel J., van Roy F. (2016) p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification PLoS Genetics 12: e1006243. *Rais B., *Köster M., *Rahim M.I., *Pils M., Seitz J.-M., *Hauser H., *Wirth D., *Mueller P.P. (2016) Evaluation of the inflammatory potential of implant materials in a mouse model by bioluminescent imaging of intravenously injected bone marrow cells Journal of Biomedical Materials Research - Part A 104: 2149 - 2158. *Spencer S., *Gugliotta A., *Gödecke N., *Hauser H., *Wirth D. (2016) Epigenetic modulations rendering cell-to-cell variability and phenotypic metastability Journal of Genetics and Genomics 43: 503 - 511. Tran D.D.H., Koch A., Saran S., Armbrecht M., Ewald F., Koch M., *Wahlicht T., *Wirth D., Braun A., Nashan B., Gästel M., Tamura T. (2016) Extracellular-signal regulated kinase (Erk1/2), mitogen-activated protein kinase-activated protein kinase 2 (MK2) and tristetraprolin (TTP) comprehensively regulate injury-induced immediate early gene (IEG) response in in vitro liver organ culture Cellular Signalling 28: 438 - 447. Lieber D., Hochdorfer D., Stoehr D., Schubert A., Lotfi R., *May T., *Wirth D., Sinzger C. (2015) A permanently growing human endothelial cell line supports productive infection with human cytomegalovirus under conditional cell growth arrest BioTechniques 59: 127 - 136. *Rand U., *Riedel J., *Hillebrand U., *Shin D., *Willenberg S., *Behme S., *Klawonn F., *Köster M., *Hauser H., *Wirth D. (2015) Single-cell analysis reveals heterogeneity in onset of transgene expression from synthetic tetracycline-dependent promoters Biotechnology Journal 10: 323 - 331.

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*Spencer S., *Gugliotta A., Koenitzer J., *Hauser H., *Wirth D. (2015) Stability of single copy transgene expression in CHOK1 cells is affected by histone modifications but not by DNA methylation Journal of Biotechnology 195: 15 - 29. *Dag F., Dolken L., *Holzki J., *Drabig A., *Weingartner A., *Schwerk J., *Lienenklaus S., *Conte I., *Geffers R., Davenport C., *Rand U., *Köster M., *Weiss S., Adler B., *Wirth D., Messerle M., *Hauser H., *Cicin-Sain L. (2014) Reversible Silencing of Cytomegalovirus Genomes by Type I Interferon Governs Virus Latency PLoS Pathogens 10: e1003962. *Kruse N., *Spencer S., *Wirth D. (2014) Rational Approaches for Transgene Expression: Targeted Integration and Episomal Maintenance in: Hauser H., W., R. (Ed.), Animal cell biotechnology in biologics production, De Gruyter 2014, pp. 173-216. *Lipps C., May T., *Wirth D. (2014) Cell lines: Generation of cell lines and biotechnological applications in: Hauser H., W., R. (Ed.), Animal cell biotechnology in biologics production, De Gruyter 2014, pp. 173-216 : 11 - 113. May T., *Lipps C., *Wirth D. (2014) Generation of cell lines and biotechnological applications in: Hauser, W. (Ed.), Animal Cell Biotechnology in Biologics Production, DeGruyter, Berlin 2014, pp. 11-37. *Rand U., *Hillebrand U., *Sievers S., *Willenberg S., *Köster M., *Hauser H., *Wirth D. (2014) Uncoupling of the dynamics of host-pathogen interaction uncovers new mechanisms of viral interferon antagonism at the single-cell level Nucleic Acids Research 42: e109. *Cebula M., *Ochel A., *Hillebrand U., *Pils M.C., Schirmbeck R., *Hauser H., *Wirth D. (2013) An Inducible Transgenic Mouse Model for Immune Mediated Hepatitis Showing Clearance of Antigen Expressing Hepatocytes by CD8+ T Cells PLoS ONE 8: e68720. *Dag F., *Weingartner A., *Butueva M., *Conte I., *Holzki J., May T., Adler B., *Wirth D., *Cicin-Sain L. (2013) A new reporter mouse cytomegalovirus reveals maintained immediate-early gene expression but poor virus replication in cycling liver sinusoidal endothelial cells Virology Journal 10: 197. Haenebalcke L., Goossens S., Dierickx P., Bartunkova S., D'Hont J., Haigh K., Hochepied T., *Wirth D., Nagy A., Haigh Jody J. (2013) The ROSA26-iPSC Mouse: A Conditional, Inducible, and Exchangeable Resource for Studying Cellular (De)Differentiation Cell Reports 3: 335 - 341. Haenebalcke L., Goossens S., Naessens M., *Kruse N., Ghahremani M.F., Bartunkova S., Haigh K., Pieters T., Dierickx P., Drogat B., Nyabi O., *Wirth D., Haigh J.J. (2013) Efficient ROSA26-Based Conditional and/or Inducible Transgenesis Using RMCE-Compatible F1 Hybrid Mouse Embryonic Stem Cells Stem Cell Reviews and Reports 9: 774 - 785. *Lipps C., May T., *Hauser H., *Wirth D. (2013) Eternity and functionality - Rational access to physiologically relevant cell lines Biological Chemistry 394: 1637 - 1648.

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Topic 3

Bilitewski, Ursula

*Bilitewski U., Blodgett J.A.V., Duhme-Klair A.-K., Dallavalle S., Laschat S., Routledge A., Schobert R.

(2017) Chemical and Biological Aspects of Nutritional Immunity-Perspectives for New Anti-Infectives

that Target Iron Uptake Systems Angewandte Chemie - International Edition 56: 14360 - 14382.

Gilardi A., Bhamidimarri S.P., *Brönstrup M., *Bilitewski U., Marreddy R.K.R., Pos K.M., Benier L.,

Gribbon P., Winterhalter M., Windshügel B. (2017) Biophysical characterization of E. coli TolC

interaction with the known blocker hexaamminecobalt Biochimica et Biophysica Acta - General

Subjects 1861: 2702 - 2709.

Kempf K., Kempf O., *Orozco M., *Bilitewski U., Schobert R. (2017) Synthesis and Structural Revision

of the Fungal Tetramic Acid Metabolite Spiroscytalin Journal of Organic Chemistry 82: 7791 - 7795.

Bruckner S., *Bilitewski U., Schobert R. (2016) Synthesis and Antibacterial Activity of Four

Stereoisomers of the Spider-Pathogenic Fungus Metabolite Torrubiellone D Organic Letters 18: 1136

- 1139.

*Cui S., *Hassan R.Y.A., *Heintz-Buschart A., *Bilitewski U. (2016) Regulation of Candida albicans

interaction with macrophages through the activation of HOG pathway by genistein Molecules 21:

162.

Gündemir-Durmaz T., Schmid F., El Baz Y., Häusser A., *Schneider C., *Bilitewski U., Rauhut G.,

Garnier D., Baro A., Laschat S. (2016) Truncated borrelidin analogues: Synthesis by sequential cross

metathesis/olefination for the southern fragment and biological evaluation Organic and

Biomolecular Chemistry 14: 8261 - 8269.

*Kaba H.E.J., *Polderl A., *Bilitewski U. (2015) Short Peptides Allowing Preferential Detection of

Candida albicans Hyphae Analytical Chemistry 87: 8629 - 8633.

*Kaba H.E.J., Maier N., Schliebe-Ohler N., Mayer Y., *Müller P.P., *van den Heuvel J., Schuchhardt J.,

Hanack K., *Bilitewski U. (2015) Identification of whole pathogenic cells by monoclonal antibodies

generated against a specific peptide from an immunogenic cell wall protein Journal of

Microbiological Methods 108: 61 - 69.

Kempf K., Schmitt F., *Bilitewski U., Schobert R. (2015) Synthesis, stereochemical assignment, and

bioactivity of the Penicillium metabolites penicillenols B1 and B2 Tetrahedron 71: 5064 - 5068.

Khodari M., *Bilitewski U., Basry A.A.H. (2015) Screen-Printed Electrodes for Amperometric

Determination of Iodide Electroanalysis 27: 281 - 284.

*Cui S., *Wienhoefer N., *Bilitewski U. (2014) Genistein induces morphology change and G2/M cell

cycle arrest by inducing p38 MAPK activation in macrophages International Immunopharmacology

18: 142 - 150.

*Cui S., *Bilitewski U. (2014) [Effect of genistein on the TLR and MAPK transduction cascades in

175

lipopolysaccharide -stimulated macrophages]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi = Chinese Journal

of Cellular and Molecular Immunology 30: 233 - 236.

*El-Mowafy M., Bahgat M.M., *Bilitewski U. (2013) Deletion of the HAMP domains from the histidine

kinase CaNik1p of Candida albicans or treatment with fungicides activates the MAP kinase Hog1p in

S. cerevisiae transformants BMC Microbiology 13: 209.

*Hassan R.Y.A., *Bilitewski U. (2013) Direct electrochemical determination of Candida albicans

activity Biosensors and Bioelectronics 49: 192 - 198.

*Heintz-Buschart A., Eickhoff H., Hohn E., *Bilitewski U. (2013) Identification of inhibitors of yeast-to-

hyphae transition in Candida albicans by a reporter screening assay Journal of Biotechnology 164:

137 - 142.

*Kaba H.E.J., *Nimtz M., *Müller P.P., *Bilitewski U. (2013) Involvement of the mitogen activated

protein kinase Hog1p in the response of Candida albicans to iron availability BMC Microbiology

13:16.

176

Brönstrup, Mark

Abouzeid S., *Beutling U., *Surup F., Abdel Bar F.M., Amer M.M., Badria F.A., Yahyazadeh M.,

*Brönstrup M., Selmar D. (2017) Treatment of Vinca minor Leaves with Methyl Jasmonate

Extensively Alters the Pattern and Composition of Indole Alkaloids Journal of Natural Products 80:

2905 - 2909.

*Depke T., *Franke R., *Brönstrup M. (2017) Clustering of MS2 spectra using unsupervised methods

to aid the identification of secondary metabolites from Pseudomonas aeruginosa Journal of

Chromatography B 1071: 19 - 28.

*Ferreira K.,* Hu H.-Y., *Fetz V., *Prochnow H., *Rais B., *Müller P.P., *Brönstrup M. (2017)

Multivalent Siderophore-DOTAM Conjugates as Theranostics for Imaging and Treatment of Bacterial

Infections Angewandte Chemie - International Edition 56: 8272 - 8276.

Fleta-Soriano E., Smutná K., Martínez J.P., Lorca Oró C., Sadiq S.K., Mirambeau G., Lopez-Iglesias C.,

Bosch M., Pol A., *Brönstrup M., Diez J., Meyerhans A. (2017) The myxobacterial metabolite

soraphen A inhibits HIV-1 by reducing virus production and altering virion composition Antimicrobial

Agents and Chemotherapy 61: e00739.

Frichert A., Jones P.G., *Brönstrup M., Lindel T. (2017) Oxidation of the Meroterpenoid (-)-Terreumol

C from the Mushroom Tricholoma terreum: Discovery of Cytotoxic Analogues Journal of Natural

Products 80: 2652 - 2658.

Gilardi A., Bhamidimarri S.P., *Brönstrup M., *Bilitewski U., Marreddy R.K.R., Pos K.M., Benier L.,

Gribbon P., Winterhalter M., Windshügel B. (2017) Biophysical characterization of E. coli TolC

interaction with the known blocker hexaamminecobalt Biochimica et Biophysica Acta - General

Subjects 1861: 2702 - 2709.

*Hüttel S., *Testolin G., *Herrmann J., Planke T., Gille F., Moreno M., *Stadler M., *Brönstrup M.,

Kirschning A., *Müller R. (2017) Discovery and Total Synthesis of Natural Cystobactamid Derivatives

with Superior Activity against Gram-Negative Pathogens Angewandte Chemie - International Edition

56: 12760 - 12764.

Kanwal S., Jensch I., Palm G.J., *Brönstrup M., *Rohde M., Kohler T.P., Somplatzki D., *Tegge W.,

Jenkinson H.F., Hammerschmidt S. (2017) Mapping the recognition domains of pneumococcal

fibronectin-binding proteins PavA and PavB demonstrates a common pattern of molecular

interactions with fibronectin type III repeats Molecular Microbiology 105: 839 - 859.

*Klahn P., *Brönstrup M. (2017) Bifunctional antimicrobial conjugates and hybrid antimicrobials

Natural Product Reports 34: 832 - 885.

Krasavin M., Parchinsky V., Kantin G., Manicheva O., Dogonadze M., Vinogradova T., *Karge B.,

*Brönstrup M. (2017) New nitrofurans amenable by isocyanide multicomponent chemistry are active

against multidrug-resistant and poly-resistant Mycobacterium tuberculosis Bioorganic and Medicinal

Chemistry 25: 1867 - 1874.

*Lukat P., *Katsuyama Y., *Wenzel S., *Binz T., König C., *Blankenfeldt W., *Brönstrup M., *Müller R.

(2017) Biosynthesis of methyl-proline containing griselimycins, natural products with anti-

177

tuberculosis activity Chemical Science 8: 7521 - 7527.

Miller A.K., *Brönstrup M. (2017) Drug Innovation in Academia: A Helmholtz Drug Research Initiative

Conference ChemMedChem 12: 1652 - 1654.

Schmidt C., *Karge B., Misgeld R., Prokop A., *Brönstrup M., Ott I. (2017) Biscarbene gold(i)

complexes: Structure-activity-relationships regarding antibacterial effects, cytotoxicity, TrxR

inhibition and cellular bioavailability MedChemComm 8: 1681 - 1689.

Schmidt C., *Karge B., Misgeld R., Prokop A., *Franke R., *Brönstrup M., Ott I. (2017) Gold(I) NHC

Complexes: Antiproliferative Activity, Cellular Uptake, Inhibition of Mammalian and Bacterial

Thioredoxin Reductases, and Gram-Positive Directed Antibacterial Effects Chemistry - A European

Journal 23: 1869 - 1880.

*Sommer R., *Wagner S., *Rox K., Varrot A., *Hauck D., Wamhoff E.-C., *Schreiber J., Ryckmans T.,

Brunner T., Rademacher C., *Hartmann R. W., *Brönstrup M., Imberty A., *Titz A. (2017)

Glycomimetic, orally bioavailable LecB inhibitors block biofilm formation of Pseudomonas aeruginosa

Journal of the American Chemical Society doi: 10.1021/jacs.7b11133.

*Van Duuren J.B.J.H., *Müsken M., *Karge B., *Tomasch J., Wittmann C., *Häussler S., *Brönstrup M.

(2017) Use of Single-Frequency Impedance Spectroscopy to Characterize the Growth Dynamics of

Biofilm Formation in Pseudomonas aeruginosa Scientific Reports 7: 5223.

Wildermuth R., Speck K., Haut F.-L., Mayer P., *Karge B., *Brönstrup M., Magauer T. (2017) A

modular synthesis of tetracyclic meroterpenoid antibiotics Nature Communications 8: 2083.

Bertrand R., Hamp I., *Brönstrup M., Weck R., Lukacevic M., Polyak A., Ross T.L., Gotthardt M.,

Plettenburg O., Derdau V. (2016) Synthesis of GPR40 targeting 3H- and 18F-probes towards selective

beta cell imaging Journal of Labelled Compounds and Radiopharmaceuticals 59: 604 - 610.

Bertrand R., Wolf A., Ivashchenko Y., Löhn M., Schäfer M., *Brönstrup M., Gotthardt M., Derdau V.,

Plettenburg O. (2016) Synthesis and Characterization of a Promising Novel FFAR1/GPR40 Targeting

Fluorescent Probe for ß-Cell Imaging ACS Chemical Biology 11: 1745 - 1754.

*Fetz V., *Prochnow H., *Brönstrup M., *Sasse F. (2016) Target identification by image analysis

Natural Product Reports 33: 655 - 667.

*Klahn P., *Brönstrup M. (2016) New structural templates for clinically validated and novel targets in

antimicrobial drug research and development Current Topics in Microbiology and Immunology 398:

365 - 417.

Nicolaou K.C., Pulukuri K.K., Rigol S., Heretsch P., Yu R., Grove C.I., Hale C.R.H., ElMarrouni A., Fetz V.,

*Brönstrup M., Aujay M., Sandoval J., Gavrilyuk J. (2016) Synthesis and Biological Investigation of

d12-Prostaglandin J3 (d12-PGJ3) Analogues and Related Compounds Journal of the American

Chemical Society 138: 6550 - 6560.

Schreuder H., Liesum A., Lönze P., Stump H., Hoffmann H., Schiell M., Kurz M., Toti L., Bauer A., Kallus

C., Klemke-Jahn C., Czech J., Kramer D., Enke H., Niedermeyer T.H.J., Morrison V., Kumar V.,

178

*Brönstrup M. (2016) Isolation, Co-Crystallization and Structure-Based Characterization of

Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor

(TAFIa) Scientific Reports 6: 32958.

*Fu C., *Keller L., Bauer A., *Brönstrup M., Froidbise A., Hammann P., *Herrmann J., Mondesert G.,

Kurz M., Schiell M., Schummer D., Toti L., *Wink J., *Müller R. (2015) Biosynthetic Studies of

Telomycin Reveal New Lipopeptides with Enhanced Activity Journal of the American Chemical

Society 137: 7692 - 7705.

*Kling A., *Lukat P., Almeida D.V., Bauer A., Fontaine E., Sordello S., *Zaburannyi N., *Herrmann J.,

*Wenzel S.C., Konig C., Ammerman N.C., Barrio M.B., Borchers K., Bordon-Pallier F., *Brönstrup M.,

Courtemanche G., Gerlitz M., Geslin M., Hammann P., *Heinz D.W., Hoffmann H., Klieber S.,

Kohlmann M., Kurz M., Lair C., Matter H., Nuermberger E., Tyagi S., Fraisse L., Grosset J.H., Lagrange

S., *Müller R.. (2015) Targeting DnaN for tuberculosis therapy using novel griselimycins Science 348:

1106 - 1112.

*Wenzel S.C., Hoffmann H., Zhang J., Debussche L., Haag-Richter S., Kurz M., Nardi F., *Lukat P.,

*Kochems I., Tietgen H., Schummer D., Nicolas J.-P., Calvet L., Czepczor V., Vrignaud P., Mühlenweg

A., Pelzer S., *Müller R., *Brönstrup M. (2015) Production of the Bengamide Class of Marine Natural

Products in Myxobacteria: Biosynthesis and Structure-Activity Relationships Angewandte Chemie -

International Edition 54: 15560 - 15564.

Halland N., *Brönstrup M., Czech J., Czechtizky W., Evers A., Follmann M., Kohlmann M., Schiell M.,

Kurz M., Schreuder H.A., Kallus C. (2015) Novel Small Molecule Inhibitors of Activated Thrombin

Activatable Fibrinolysis Inhibitor (TAFIa) from Natural Product Anabaenopeptin Journal of Medicinal

Chemistry 58: 4839 - 4844.

Hoffmann H., Kogler H., Heyse W., Matter H., Caspers M., Schummer D., Klemke-Jahn C., Bauer A.,

Penarier G., Debussche L., *Brönstrup M. (2015) Discovery, Structure Elucidation, and Biological

Characterization of Nannocystin A, a Macrocyclic Myxobacterial Metabolite with Potent

Antiproliferative Properties Angewandte Chemie - International Edition 54: 10145 - 10148.


*Kalesse M., *Harmrolfs K., *Müller R., Martinez J.P., *Pietschmann T., Bartenschlager R., *Brönstrup



Martinez J.P., *Sasse F., *Brönstrup M., Diez J., Meyerhans A. (2015) Antiviral drug discovery: Broad-

spectrum drugs from nature Natural Product Reports 32: 29 - 48.

Zapolskii V.A., Namyslo J.C., *Sergeev G., *Brönstrup M., Gjikaj M., Kaufmann D.E. (2015)

Reinvestigation of the Nitration of Tri-chloroethene - Subsequent Reactions of the Products and

Evaluation of Their Anti-microbial and Antifungal Activity European Journal of Organic Chemistry

2015: 7763 - 7774.

Bauer A., *Brönstrup M. (2014) Industrial natural product chemistry for drug discovery and

development Natural Product Reports 31: 35 - 60.

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Kopf T., Schaefer H.-L., Troetzmueller M., Koefeler H., *Brönstrup M., Konovalova T., Schmitz G.

(2014) Influence of fenofibrate treatment on triacylglycerides, diacylglycerides and fatty acids in

fructose fed rats PLoS ONE 9: e106849.


Férir G., Petrova M.I., Andrei G., Huskens D., Hoorelbeke B., Snoeck R., Vanderleyden J., Balzarini J.,

Bartoschek S., Brönstrup M., Süssmuth R.D., Schols D. (2013) The Lantibiotic Peptide

Labyrinthopeptin A1 Demonstrates Broad Anti-HIV and Anti-HSV Activity with Potential for

Microbicidal Applications PLoS ONE 8: e64010.

Krawczyk J.M., Völler G.H., Krawczyk B., Kretz J., Brönstrup M., Süssmuth R.D. (2013) Heterologous

expression and engineering studies of labyrinthopeptins, new type III lantibiotics from Actinomadura

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Fuhrmann, Gregor

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Fuhrmann G., Herrmann I.K., Stevens M.M. (2015) Cell-derived vesicles for drug therapy and

diagnostics: opportunities and challenges Nano Today 10: 397 - 409.

Fuhrmann G., Serio A., Mazo M., Nair R., Stevens M.M. (2015), Active loading into extracellular

vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins Journal of

Controlled Release 205: 35 – 44.

Santos L., Fuhrmann G., Juenet M., Amdursky N., Horejs C.-M., Campagnolo P., Stevens M.M. (2015)

Extracellular stiffness modulates the expression of functional proteins and growth factors in

endothelial cells Advanced Healthcare Materials 4: 2056 - 2063.

Fuhrmann G., Leroux J.C. (2014) Improving the stability and activity of oral therapeutic enzymes -

recent advances and perspectives Pharmaceutical Research 31:1099 - 1105.

Fuhrmann G., Gauthier M.A., Leroux J.C. (2013) Polymer-enzyme conjugates for oral drug delivery

applications Chimia 67: 685 - 686.

Fuhrmann G., Grotzky A., Lukic R., Matoori S., Luciani P., Zhang B., Yu H., Walde P., Schlüter A.D.,

Gauthier M.A., Leroux J.C. (2013) Sustained gastrointestinal activity of dendronized polymer-enzyme

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Hartmann, Rolf W.

*Emmerich J., van Koppen C.J., Burkhart J.L., Engeli R.T., *Hu Q., Odermatt A., *Hartmann R.W.

(2018) Accelerated skin wound healing by selective 11ß-Hydroxylase (CYP11B1) inhibitors European

Journal of Medicinal Chemistry 143: 591 - 597.

*Surup F., *Viehrig K., *Rachid S., *Plaza A., *Maurer C.K., *Hartmann R.W., *Müller R. (2018)

Crocadepsins-Depsipeptides from the Myxobacterium Chondromyces crocatus Found by a Genome

Mining Approach ACS Chemical Biology 13: 267–272.

*Allegretta G., *Maurer C.K., *Eberhard J., Maura D., *Hartmann R.W., Rahme L., *Empting M. (2017)

In-depth profiling of MvfR-regulated small molecules in Pseudomonas aeruginosa after Quorum

Sensing inhibitor treatment Frontiers in Microbiology 8: 924.

*Brengel C., *Thomann A., *Schifrin A., *Allegretta G., *Kamal A.A.M., *Haupenthal J., *Schnorr I.,

Cho S.H., Franzblau S.G., *Empting M., *Eberhard J., *Hartmann R.W. (2017) Biophysical Screening of

a Focused Library for the Discovery of CYP121 Inhibitors as Novel Antimycobacterials

ChemMedChem 12: 1616 - 1626.

*de Mello Martins A.G.G., *Allegretta G., Unteregger G., *Haupenthal J., *Eberhard J., *Hoffmann

M., van der Zee J.A., Junker K., Stöckle M., *Müller R., *Hartmann R.W., Ohlmann C.-H. (2017)

CYP17A1-independent production of the neurosteroid-derived 5a-pregnan-3ß,6a-diol-20-one in

androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone

Journal of Steroid Biochemistry and Molecular Biology 174: 183 - 191.

Emmerich J., Van Koppen C.J., Burkhart J.L., *Hu Q., Siebenbürger L., Boerger C., Scheuer C., Laschke

M.W., Menger M.D., *Hartmann R.W. (2017) Lead Optimization Generates CYP11B1 Inhibitors of

Pyridylmethyl Isoxazole Type with Improved Pharmacological Profile for the Treatment of Cushing's

Disease Journal of Medicinal Chemistry 60: 5086 - 5098.

Fazli M., Rybtke M., Steiner E., *Weidel E., Berthelsen J., Groizeleau J., Bin W., Zhi B.Z., Yaming Z.,

Kaever V., Givskov M., *Hartmann R.W., Eberl L., Tolker-Nielsen T. (2017) Regulation of Burkholderia

cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB MicrobiologyOpen 6:

e00480.

Gobbi S., Hu Q., *Zimmer C., Belluti F., Rampa A., *Hartmann R.W., Bisi A. (2017) Drifting of heme-

coordinating group in imidazolylmethylxanthones leading to improved selective inhibition of

CYP11B1 European Journal of Medicinal Chemistry 139: 60 - 67.

Haidar S., *Hartmann R.W. (2017) Computational prediction of new CYP17 inhibitors based on

pharmacophore modeling, virtual screening and docking approach Pharmazie 72: 529 - 536.

*Kamal A.A.M., *Petrera L., *Eberhard J., *Hartmann R.W. (2017) Structure-functionality relationship

and pharmacological profiles of Pseudomonas aeruginosa alkylquinolone quorum sensing

modulators Organic and Biomolecular Chemistry 15: 4620 - 4630.

Schönauer E., Kany A.M., *Haupenthal J., *Hüsecken K., Hoppe I.J., Voos K., *Yahiaoui S., Elsässer B.,

Ducho C., Brandstetter H., *Hartmann R.W. (2017) Discovery of a Potent Inhibitor Class with High

Selectivity toward Clostridial Collagenases Journal of the American Chemical Society 139: 12696 -

182

12703.





Abdel-Halim M., Darwish S.S., ElHady A.K., Hoppstädter J., Abadi A.H., *Hartmann R.W., Kiemer A.K.,

Engel M. (2016) Pharmacological inhibition of protein kinase C (PKC)ζ downregulates the expression

of cytokines involved in the pathogenesis of chronic obstructive pulmonary disease (COPD) European

Journal of Pharmaceutical Sciences 93: 405 - 409.

Aggarwal S., Mahapatra M.K., Kumar R., Bhardwaj T.R., *Hartmann R.W., *Haupenthal J., Kumar M.

(2016) Synthesis and biological evaluation of 3-tetrazolo steroidal analogs: Novel class of 5 alpha-

reductase inhibitors Bioorganic and Medicinal Chemistry 24: 779 - 788.

Ahmed N.S., Elghazawy N.H., ElHady A.K., *Engel M., *Hartmann R.W., Abadi A.H. (2016) Design and

synthesis of novel tamoxifen analogues that avoid CYP2D6 metabolism European Journal of

Medicinal Chemistry 112: 171 - 179.

*Brengel C., *Thomann A., Schifrin A., *Eberhard J., *Hartmann R.W. (2016) Discovery and

Biophysical Evaluation of First Low Nanomolar Hits Targeting CYP125 of M. tuberculosis

ChemMedChem 11: 2385 - 2391.

Chen X., Ruider S.A., *Hartmann R.W., González L., Maulide N. (2016) Metal-Free meta-Selective

Alkyne Oxyarylation with Pyridine N-Oxides: Rapid Assembly of Metyrapone Analogues Angewandte

Chemie - International Edition 55: 15424 - 15428.

*Elgaher W.A.M., Sharma K.K., *Haupenthal J., Saladini F., Pires M., Real E., Mély Y., *Hartmann R.W.

(2016) Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual

Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors Journal of Medicinal Chemistry

59: 7212 - 7222.

Elghazawy N.H., *Engel M., *Hartmann R.W., *Hamed M.M., Ahmed N.S., Abadi A.H. (2016) Design

and synthesis of novel flexible ester-containing analogs of tamoxifen and their evaluation as

anticancer agents Future Medicinal Chemistry 8: 249 - 256.

Gargano E.M., Perspicace E., Carotti A., Marchais-*Oberwinkler S., *Hartmann R.W. (2016)

Addressing cytotoxicity of 1,4-biphenyl amide derivatives: Discovery of new potent and selective 17β-

hydroxysteroid dehydrogenase type 2 inhibitors Bioorganic and Medicinal Chemistry Letters 26: 21 -

24.

Gobbi S., *Hu Q., *Zimmer C., *Engel M., Belluti F., Rampa A., *Hartmann R.W., Bisi A. (2016)

Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis


Gobbi S., *Hu Q., *Zimmer C., Belluti F., Rampa A.,* Hartmann R.W., Bisi A. (2016) Targeting

Steroidogenic Cytochromes P450 (CYPs) with 6-Substituted 1-Imidazolylmethylxanthones

183

ChemMedChem : 1770 - 1777.

Mariano M., *Hartmann R.W., Engel M. (2016) Systematic diversification of benzylidene heterocycles

yields novel inhibitor scaffolds selective for Dyrk1A, Clk1 and CK2 European Journal of Medicinal

Chemistry 112: 209 - 216.

*Maurer C.K., *Fruth M., *Empting M., Avrutina O., *Hoßmann J., *Nadmid S., Gorges J., *Herrmann

J., Kazmaier U., *Dersch P., *Müller R., *Hartmann R.W. (2016) Discovery of the first small-molecule

CsrA-RNA interaction inhibitors using biophysical screening technologies Future Medicinal Chemistry

8: 931 - 947.

*Thomann A., *Brengel C., Börger C., Kail D., *Steinbach A., *Empting M., *Hartmann R.W. (2016)

Structure-Activity Relationships of 2-Sufonylpyrimidines as Quorum-Sensing Inhibitors to Tackle

Biofilm Formation and eDNA Release of Pseudomonas aeruginosa ChemMedChem 11: 2522 - 2533.

*Thomann A., *De Mello Martins A.G.G., *Brengel C., *Empting M., *Hartmann R.W. (2016)

Application of Dual Inhibition Concept within Looped Autoregulatory Systems toward Antivirulence

Agents against Pseudomonas aeruginosa Infections ACS Chemical Biology 11: 1279 - 1286.

Udhane S.S., Dick B., Hu Q., *Hartmann R.W., Pandey A.V. (2016) Specificity of anti-prostate cancer

CYP17A1 inhibitors on androgen biosynthesis Biochemical and Biophysical Research

Communications 477: 1005 - 1010.

*Wagner S., *Sommer R., *Hinsberger S., *Lu C., *Hartmann R.W., *Empting M., *Titz A. (2016) Novel

Strategies for the Treatment of Pseudomonas aeruginosa Infections Journal of Medicinal Chemistry

59: 5929 - 5969.

*Zender M., *Witzgall F., Drees S.L., *Weidel E., *Maurer C.K., Fetzner S., *Blankenfeldt W., *Empting

M., *Hartmann R.W. (2016) Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa

Virulence by Discovery of Small Tool Compounds ACS Chemical Biology 11: 1755 - 1763.

Adam O., *Zimmer C., *Hanke N., *Hartmann R.W., Klemmer B., Bohm M., Laufs U. (2015) Inhibition

of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice

Journal of Molecular and Cellular Cardiology 85: 140 - 150.

*Allegretta G., *Weidel E., *Empting M., *Hartmann R.W. (2015) Catechol-based substrates of

chalcone synthase as a scaffold for novel inhibitors of PqsD European Journal of Medicinal

Chemistry 90: 351 - 359.

*Dimer F., *de Souza Carvalho-Wodarz C., *Haupenthal J., *Hartmann R., *Lehr C.M. (2015) Inhalable

Clarithromycin Microparticles for Treatment of Respiratory Infections Pharmaceutical Research 32:

3850 - 3861.

Gargano E.M., *Allegretta G., Perspicace E., Carotti A., Van Koppen C., Frotscher M., *Marchais-

Oberwinkler S., *Hartmann R.W. (2015) 17ß-hydroxysteroid dehydrogenase type 2 inhibition:

Discovery of selective and metabolically stable compounds inhibiting both the human enzyme and its

murine ortholog PLoS ONE 10: e0134754.

184

*Grombein C.M., *Hu Q., *Heim R., *Rau S., *Zimmer C., *Hartmann R.W. (2015) 1-Phenylsulfinyl-3-

(pyridin-3-yl)naphthalen-2-ols: A new class of potent and selective aldosterone synthase inhibitors

European Journal of Medicinal Chemistry 89: 597 - 605.

Hoyt S.B., Petrilli W., London C., Liang G.-B., Tata J., *Hu Q., *Yin L., Van Koppen C.J., *Hartmann

R.W., Struthers M., Wisniewski T., Ren N., Bopp C., Sok A., Cai T.-Q., Stribling S., Pai L.-Y., Ma X.,

Metzger J., Verras A., McMasters D., Chen Q., Tung (2015) Discovery of Triazole CYP11B2 Inhibitors

with in Vivo Activity in Rhesus Monkeys ACS Medicinal Chemistry Letters 6: 861 - 865.

*Hu Q., *Yin L., Ali A., Cooke A.J., Bennett J., Ratcliffe P., Lo M.M., Metzger E., Hoyt S., *Hartmann

R.W. (2015) Novel Pyridyl Substituted 4,5-Dihydro-[1,2,4]triazolo[4,3-a]quinolines as Potent and

Selective Aldosterone Synthase Inhibitors with Improved in Vitro Metabolic Stability Journal of


*Hu Q., Kunde J., Hanke N., *Hartmann R.W. (2015) Identification of 4-(4-nitro-2-

phenethoxyphenyl)pyridine as a promising new lead for discovering inhibitors of both human and rat

11β-Hydroxylase European Journal of Medicinal Chemistry 96: 139 - 150.

*Maurer C.K., *Lu C., *Empting M., *Hartmann R.W. (2015) Synthetic quorum sensing inhibitors

(QSIs) blocking receptor signaling or signal molecule biosynthesis in Pseudomonas aeruginosa In:

Kalia V.C. (ed.) Quorum Sensing vs Quorum Quenching: A Battle with No End in Sight. Springer, New

Delhi. pp. 303 - 318.

Moreno M., *Elgaher W.A.M., *Herrmann J., Schlager N., *Hamed M.M., *Baumann S., *Müller R.,

*Hartmann R.W., Kirschning A. (2015) Synthesis and biological evaluation of cystobactamid 507: A

bacterial topoisomerase inhibitor from Cystobacter sp. Synlett 26: 1175 - 1178.

*Sahner J.H., *Empting M., *Kamal A., *Weidel E., *Groh M., Borger C., *Hartmann R.W. (2015)

Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum

sensing enzyme PqsD from Pseudomonas aeruginosa European Journal of Medicinal Chemistry 96:

14 - 21.

*Sahner J.H., *Sucipto H., *Wenzel S.C., *Groh M., *Hartmann R.W., *Müller R. (2015) Advanced

Mutasynthesis Studies on the Natural α-Pyrone Antibiotic Myxopyronin from Myxococcus fulvus

ChemBioChem 16: 946 - 953.

Stefanachi A., *Hanke N., Pisani L., Leonetti F., Nicolotti O., Catto M., Cellamare S., *Hartmann R.W.,

Carotti A. (2015) Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-

imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-

hydroxylase European Journal of Medicinal Chemistry 89: 106 - 114.

*Sucipto H., *Sahner J.H., *Prusov E., *Wenzel S.C., *Hartmann R.W., *Koehnke J., *Müller R. (2015)

In vitro reconstitution of α-pyrone ring formation in myxopyronin biosynthesis Chemical Science 6:

5076 - 5085.

*Thomann A., *Eberhard J., *Allegretta G., *Empting M., *Hartmann R.W. (2015) Mild and Catalyst-

Free Microwave-Assisted Synthesis of 4,6-Disubstituted 2-Methylthiopyrimidines - Exploiting

Tetrazole as an Efficient Leaving Group Synlett 26: 2606 - 2610.

185

*Thomann A., Huch V., *Hartmann R.W. (2015) Crystal structure of 4-methylsulfanyl-2-(2H-tetrazol-

2-yl)pyrimidine Acta Crystallographica Section E: Crystallographic Communications 71: o1051 -

o1052.

*Thomann A., Zapp J., Hutter M., *Empting M., *Hartmann R.W. (2015) Steering the azido-tetrazole

equilibrium of 4-azidopyrimidines via substituent variation-implications for drug design and azide-

alkyne cycloadditions Organic and Biomolecular Chemistry 13: 10620 - 10630.

Van Koppen C.J., *Hartmann R.W. (2015) Advances in the treatment of chronic wounds: A patent

review Expert Opinion on Therapeutic Patents 25: 931 - 937.

Abdelsamie A.S., Bey E., Hanke N., *Empting M., *Hartmann R.W., Frotscher M. (2014) Inhibition of

17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent

inhibitors with thioether linker European Journal of Medicinal Chemistry 82: 394 - 406.

*Elgaher W.A.M., *Fruth M., *Groh M., *Haupenthal J., *Hartmann R.W. (2014) Expanding the

scaffold for bacterial RNA polymerase inhibitors: Design, synthesis and structure-activity

relationships of ureido-heterocyclic-carboxylic acids RSC Advances 4: 2177 - 2194.

*Fruth M., *Plaza A., *Hinsberger S., *Sahner J.H., *Haupenthal J., Bischoff M., *Jansen R., *Müller

R., *Hartmann R.W. (2014) Binding mode characterization of novel RNA polymerase inhibitors using a

combined biochemical and NMR approach ACS chemical biology 9: 2656 - 2663.

Gargano E.M., Perspicace E., Hanke N., Carotti A., Marchais-Oberwinkler S., *Hartmann R.W. (2014)

Metabolic stability optimization and metabolite identification of 2,5-thiophene amide 17β -

hydroxysteroid dehydrogenase type 2 inhibitors European Journal of Medicinal Chemistry 87: 203 -

219.

Grombein C.M., Hu Q., Rau S., Zimmer C., *Hartmann R.W. (2014) Heteroatom insertion into 3,4-

dihydro-1 H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone

synthase European Journal of Medicinal Chemistry 90: 788 - 796.

*Hinsberger S., *De Jong J.C., *Groh M., *Haupenthal J., *Hartmann R.W. (2014) Benzamidobenzoic

acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections European


*Hu Q., *Yin L., *Hartmann R.W. (2014) Aldosterone synthase inhibitors as promising treatments for

mineralocorticoid dependent cardiovascular and renal diseases Journal of Medicinal Chemistry 57:

5011 - 5022.

*Hüsecken K., *Hinsberger S., *Elgaher W.A.M., *Haupenthal J., *Hartmann R.W. (2014) Surface

plasmon resonance - More than a screening technology: Insights in the binding mode of σ70:Core

RNAP inhibitors Future Medicinal Chemistry 6: 1551 - 1565.

Hutter M.C., *Brengel C., *Negri M., *Henn C., *Zimmer C., *Hartmann R.W., *Empting M.,

*Steinbach A. (2014) Mechanistic details for anthraniloyl transfer in PqsD: The initial step in HHQ

biosynthesis Journal of Molecular Modeling 20: 2255.

186

Laggai S., Kessler S.M., Boettcher S., Lebrun V., *Gemperlein K., Lederer E., Leclercq I.A., *Mueller R.,

*Hartmann R.W., Haybaeck J., Kiemer A.K. (2014) The IGF2 mRNA binding protein p62/IGF2BP2-2

induces fatty acid elongation as a critical feature of steatosis Journal of Lipid Research 55: 1087 -

1097.

*Lu C., *Kirsch B., *Maurer C.K., *De Jong J.C., *Braunshausen A., *Steinbach A., *Hartmann R.W.

(2014) Optimization of anti-virulence PqsR antagonists regarding aqueous solubility and biological

properties resulting in new insights in structure-activity relationships European Journal of Medicinal

Chemistry 79: 173 - 183.

*Lu C., *Maurer C.K., *Kirsch B., *Steinbach A., *Hartmann R.W. (2014) Overcoming the unexpected

functional inversion of a PqsR antagonist in Pseudomonas aeruginosa: An in vivo potent antivirulence

agent targeting pqs quorum sensing Angewandte Chemie - International Edition 53: 1109 - 1112.

Miralinaghi P., Schmitt C., *Hartmann R.W., Frotscher M., Engel M. (2014) 6-Hydroxybenzothiophene

ketones: Potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) owing to

favorable molecule geometry and conformational preorganization ChemMedChem 9: 2294 - 2308.

*Nafee N., *Husari A., *Maurer C.K., *Lu C., *De Rossi C., *Steinbach A., *Hartmann R.W., *Lehr C.-

M., Schneider M. (2014) Antibiotic-free nanotherapeutics: Ultra-small, mucus-penetrating solid lipid

nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing

inhibitors Journal of Controlled Release 192: 131 - 140.

Perspicace E., Cozzoli L., Gargano E.M., Hanke N., Carotti A., *Hartmann R.W., Marchais-Oberwinkler

S. (2014) Novel, potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors as

potential therapeutics for osteoporosis with dual human and mouse activities European Journal of


Schmitt C., Kail D., Mariano M., *Empting M., Weber N., Paul T., *Hartmann R.W., Engel M. (2014)

Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective

Dyrk/Clk inhibitors PLoS ONE 9: e87851.

Schmitt C., Miralinaghi P., Mariano M., *Hartmann R.W., Engel M. (2014) Hydroxybenzothiophene

ketones are efficient pre-mRNA splicing modulators due to dual inhibition of Dyrk1A and Clk1/4 ACS

Medicinal Chemistry Letters 5: 963 - 967.

*Storz M.P., *Allegretta G., *Kirsch B., *Empting M., *Hartmann R.W. (2014) From in vitro to in

cellulo: Structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in

Pseudomonas aeruginosa Organic and Biomolecular Chemistry 12: 6094 - 6104.

*Thomann A., Börger C., *Empting M., *Hartmann R.W. (2014) Microwave-assisted synthesis of 4-

substituted 2-methylthiopyrimidines Synlett 25: 935 - 938.

*Weidel E., *Negri M., *Empting M., *Hinsberger S., *Hartmann R.W. (2014) Composing compound

libraries for hit discovery-rationality-driven preselection or random choice by structural diversity?

Future Medicinal Chemistry 6: 2057 - 2072.

187

Yin L., Hu Q., Emmerich J., Lo M.M.-C., Metzger E., Ali A., *Hartmann R.W. (2014) Novel pyridyl- or

isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase

inhibitors Journal of Medicinal Chemistry 57: 5179 - 5189.

*Zhu W., *Haupenthal J., *Groh M., *Fountain M., *Hartmann R.W. (2014) New insights into the

bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective

agent Antimicrobial Agents and Chemotherapy 58: 4242 - 4245.

*Zhu W., *Hu Q., Hanke N., Van Koppen C.J., *Hartmann R.W. (2014) Potent 11ß-hydroxylase

inhibitors with inverse metabolic stability in human plasma and hepatic S9 fractions to promote

wound healing Journal of Medicinal Chemistry 57: 7811 - 7817.

Berenyi A., Frotscher M., Marchais-Oberwinkler S., *Hartmann R.W., Minorics R., Ocsovszki I., Falkay

G., Zupko I. (2013) Direct antiproliferative effect of nonsteroidal 17β-hydroxysteroid dehydrogenase

type 1 inhibitors in vitro Journal of Enzyme Inhibition and Medicinal Chemistry 28: 695 - 703.

El-Gamil D.S., Ahmed N.S., Gary B.D., Piazza G.A., *Engel M., *Hartmann R.W., Abadi A.H. (2013)

Design of novel β-carboline derivatives with pendant 5-bromothienyl and their evaluation as

phosphodiesterase-5 inhibitors Archiv der Pharmazie 346: 23 - 33.

*Emmerich J., *Hu Q., Hanke N., *Hartmann R.W. (2013) Cushing's syndrome: Development of highly

potent and selective CYP11B1 inhibitors of the (pyridylmethyl)pyridine type Journal of Medicinal

Chemistry 56: 6022 - 6032.

Ferlin M.G., Carta D., Bortolozzi R., Ghodsi R., Chimento A., Pezzi V., Moro S., Hanke N., *Hartmann

R.W., Basso G., Viola G. (2013) Design, synthesis, and structure-activity relationships of

azolylmethylpyrroloquinolines as nonsteroidal aromatase inhibitors Journal of Medicinal Chemistry

56: 7536 - 7551.

Gobbi S., *Hu Q., *Negri M., *Zimmer C., Belluti F., Rampa A., *Hartmann R.W., Bisi A. (2013)

Modulation of cytochromes P450 with xanthone-based molecules: From aromatase to aldosterone

synthase and steroid 11β-hydroxylase inhibition Journal of Medicinal Chemistry 56: 1723 - 1729.

*Grombein C.M., *Hu Q., *Heim R., Huch V., *Hartmann R.W. (2013) Unexpected results of a SNAr-

reaction. A novel synthetic approach to 1-arylthio-2-naphthols Tetrahedron Letters 54: 6615 - 6618.

*Hamed M.M., Abou El Ella D.A., Keeton A.B., Piazza G.A., Engel M., *Hartmann R.W., Abadi A.H.

(2013) Quinazoline and tetrahydropyridothieno[2,3-d]pyrimidine derivatives as irreversible EGFR

tyrosine kinase inhibitors: Influence of the position 4 substituent MedChemComm 4: 1202 - 1207.

*Hamed M.M., AbouElElla D.A., Keeton A.B., Piazza G.A., Abadi A.H., *Hartmann R.W., *Engel M.

(2013) 6-Aryl and heterocycle quinazoline derivatives as potent EGFR inhibitors with improved

activity toward gefitinib-sensitive and -resistant tumor cell lines ChemMedChem 8: 1495 - 1504.

*Hinsberger S., *Husecken K., *Groh M., *Negri M., *Haupenthal J., *Hartmann R.W. (2013)

Discovery of novel bacterial RNA polymerase inhibitors: Pharmacophore-based virtual screening and

hit optimization Journal of Medicinal Chemistry 56: 8332 - 8338.

188

Hu Q., *Hartmann R.W. (2013) The Renaissance of CYP17 Inhibitors for the Treatment of Prostate

Cancer Cancer Drug Design and Discovery: Second Edition : 319 - 356.

*Husecken K., *Negri M., Fruth M., Boetcher S., *Hartmann R.W., *Haupenthal J. (2013) Peptide-

based investigation of the escherichia coli RNA polymerase σ70:Core interface as target site ACS

Chemical Biology 8: 758 - 766.

Krug S.J., Hu Q., *Hartmann R.W. (2013) Hits identified in library screening demonstrate selective

CYP17A1 lyase inhibition Journal of Steroid Biochemistry and Molecular Biology 134: 75 - 79.

Marchais-Oberwinkler S., Xu K., Wetzel M., Perspicace E., *Negri M., Meyer A., Odermatt A., Moller

G., Adamski J., *Hartmann R.W. (2013) Structural optimization of 2,5-thiophene amides as highly

potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of

osteoporosis Journal of Medicinal Chemistry 56: 167 - 181.

*Maurer C.K., *Steinbach A., *Hartmann R.W. (2013) Development and validation of a UHPLC-

MS/MS procedure for quantification of the Pseudomonas Quinolone Signal in bacterial culture after

acetylation for characterization of new quorum sensing inhibitors Journal of Pharmaceutical and

Biomedical Analysis 86: 127 - 134.

Perspicace E., Giorgio A., Carotti A., Marchais-Oberwinkler S., *Hartmann R.W. (2013) Novel N-

methylsulfonamide and retro-N-methylsulfonamide derivatives as 17β-hydroxysteroid

dehydrogenase type 2 (17β-HSD2) inhibitors with good ADME-related physicochemical parameters

European Journal of Medicinal Chemistry 69: 201 - 215.

Perspicace E., Marchais-Oberwinkler S., *Hartmann R.W. (2013) Synthesis and biological evaluation

of thieno[3,2-d]- pyrimidinones, thieno[3,2-d]pyrimidines and quinazolinones: Conformationally

restricted 17b-hydroxysteroid dehydrogenase type 2 (17b-HSD2) inhibitors Molecules 18: 4487 -

4509.

*Pinto-Bazurco Mendieta M.A.E., *Hu Q., *Engel M., *Hartmann R.W. (2013) Highly potent and

selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to

reduce risks of cardiovascular diseases Journal of Medicinal Chemistry 56: 6101 - 6107.

*Sahner J.H., *Brengel C., *Storz M.P., *Groh M., *Plaza A., *Müller R., *Hartmann R.W. (2013)

Combining in silico and biophysical methods for the development of Pseudomonas aeruginosa

quorum sensing inhibitors: An alternative approach for structure-based drug design Journal of


Schaadt N.S., Steinbach A., *Hartmann R.W., Helms V. (2013) Rule-based regulatory and metabolic

model for Quorum sensing in P. aeruginosa BMC Systems Biology 7: 81.

*Steinbach A., *Maurer C.K., Weidel E., *Henn C., *Brengel C., *Hartmann R.W., *Negri M. (2013)

Molecular basis of HHQ biosynthesis: Molecular dynamics simulations, enzyme kinetic and surface

plasmon resonance studies BMC Biophysics 6: 6.

*Storz M.P., *Brengel C., *Weidel E., *Hoffmann M., Hollemeyer K., *Steinbach A., *Müller R.,

*Empting M., *Hartmann R.W. (2013) Biochemical and biophysical analysis of a chiral PqsD inhibitor

189

revealing tight-binding behavior and enantiomers with contrary thermodynamic signatures ACS


Weidel E., *De Jong J.C., *Brengel C., *Storz M.P., *Braunshausen A., *Negri M., *Plaza A., *Steinbach

A., *Müller R., *Hartmann R.W. (2013) Structure optimization of 2-benzamidobenzoic acids as PqsD

inhibitors for Pseudomonas aeruginosa infections and elucidation of binding mode by SPR, STD NMR,

and molecular docking Journal of Medicinal Chemistry 56: 6146 - 6155.

*Yin L., *Hu Q., *Hartmann R.W. (2013) Tetrahydropyrroloquinolinone type dual inhibitors of

aromatase/aldosterone synthase as a novel strategy for breast cancer patients with elevated

cardiovascular risks Journal of Medicinal Chemistry 56: 460 - 470.

*Yin L., *Hu Q., *Hartmann R.W. (2013) Recent progress in pharmaceutical therapies for castration-

resistant prostate cancer International Journal of Molecular Sciences 14: 13958 - 13978.

*Zender M., *Klein T., *Henn C., *Kirsch B., *Maurer C.K., Kail D., *Ritter C., Dolezal O., *Steinbach A.,

*Hartmann R.W. (2013) Discovery and biophysical characterization of 2-amino-oxadiazoles as novel

antagonists of PqsR, an important regulator of Pseudomonas aeruginosa virulence Journal of


*Zhu W., *Groh M., *Haupenthal J., *Hartmann R.W. (2013) A detective story in drug discovery:

Elucidation of a screening artifact reveals polymeric carboxylic acids as potent inhibitors of RNA

polymerase Chemistry - A European Journal 19: 8397 - 8400.

190

Hirsch, Anna

Liu Y., deVries J.W., Liu Q., *Hartman A.M., Wieland G.D., Wieczorek S., Börner H.G., Wiehe A., Buhler E., Stuart M.C.A., Browne W.R., Herrmann A., *Hirsch A.K.H. (2018) Lipid-DNAs as Solubilizers of mTHPC Chemistry - A European Journal 24: 798 - 802. Marcozzi A., Masini T., *Zhu D., Pesce D., Illarionov B., Fischer M., Herrmann A., *Hirsch A.K.H. (2018) Phage display on anti-infective target DXS led to an acceptor-substrate competitive peptidic inhibitor Chembiochem 19: 58 - 65. Te Poele E.M., Devlamynck T., Jäger M., Gerwig G.J., van de Walle D., Dewettinck K., *Hirsch A.K.H., Kamerling J.P., Soetaert W., Dijkhuizen L. (2018) Glucansucrase (mutant) enzymes from Lactobacillus reuteri 180 efficiently transglucosylate Stevia component rebaudioside A, resulting in a superior taste Scientific Reports doi:10.1038/s41598-018-19622-5. Liu Y., Stuart M.C.A., Witte M.D., Buhler E., *Hirsch A.K.H. (2017) Saccharide-Containing Dynamic Proteoids Chemistry - A European Journal 23: 16162 – 16166. Monjas L., Swier L.J.Y.M., Setyawati I., Slotboom D.J., *Hirsch A.K.H. (2017) Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine ChemMedChem 12: 1693 - 1696. Nasti R., Rossi D., Amadio M., Pascale A., *Unver M.Y., *Hirsch A.K.H., Collina S. (2017) Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein–RNA Complexes: An Avenue for Discovering New Drugs Journal of Medicinal Chemistry 60: 8257 - 8267. Publications before start at HZI Dockerty P., Edens J.D., Tol M.B., Morales Angeles D., Domenech A., Liu Y., Hirsch A.K.H., Veening J.W., Scheffers D.J., Witte M.D. (2017) Bicyclic enol cyclocarbamates inhibit penicillin-binding proteins Organic & Biomolecular Chemistry 15: 894 - 910. Gierse R.M., Reddem E., Diamanti E., Wrenger C., Groves M.R., Hirsch A.K.H. (2017) DXS as a target for structure-based drug design Future Medicinal Chemistry 9: 1277 - 1294.

Hartman A.M., Hirsch A.K.H. (2017) Molecular Insight into Specific 14-3-3 Modulators: Inhibitors and Stabilisers of Protein-Protein Interactions of 14-3-3 European Journal of Medicinal Chemistry 136: 573 – 584. Liu Y., Lehn J.M., Hirsch A.K.H. (2017) Molecular Biodynamers: Dynamic Covalent Analogues of Biopolymers Accounts of Chemical Research 50: 376 - 386. Morales Angeles D., Liu Y., Hartman A.M., Borisova M., de Sousa Borges A., de Kok N., Beilharz K., Veening J.W., Mayer C., Hirsch A.K.H., Scheffers D.J. (2017) Pentapeptide-rich peptidoglycan at the Bacillus subtilis cell-division site Molecular Microbiology 104: 319 - 333. Scheepstra M., Andrei S.A., Unver M.Y., Hirsch A.K.H., Leysen S., Ottmann C., Brunsveld L., Milroy L.G. (2017) Designed Spiroketal Protein Modulation Angewandte Chemie International Edition 56: 5480–5484, Angewandte Chemie 129: 5572 – 5576. Van der Vlag R., Hirsch A.K.H. (2017) Analytical Methods in Protein-Templated Dynamic

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Combinatorial Chemistry Comprehensive Supramolecular Chemistry II, Elsevier 5: 487 - 509. Wieczorek S., Remmler D., Masini T., Kochovski Z., Hirsch A.K.H., Börner H.G. (2017) Fine-tuning Nanocarriers Specifically toward Cargo: A Competitive Study on Solubilizing Related Photosensitizers for Photodynamic Therapy Bioconjugate Chemistry 28: 760 – 767. Liu Y., Stuart M.C.A., Buhler E., Lehn J.M., Hirsch A.K.H. (2016) Proteoid Dynamers with Tunable Properties Advanced Functional Materials 26: 6297 - 6305. Masini T., Birkaya B., van Dijk S., Mondal M., Hekelaar J., Jäger M., Terwisscha van Scheltinga A.C., Patel M.S., Hirsch A.K.H., Moman E. (2016) Furoates and Thenoates Inhibit Pyruvate Dehydrogenase Kinase 2 Allosterically by Binding to its Pyruvate Regulatory Site Journal of Enzyme Inhibition and Medicinal Chemistry 31: 170 - 175. Mondal M., Radeva N., Fanlo-Virgós H., Otto S., Klebe G., Hirsch A.K.H. (2016) Fragment-Linking and -Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial Chemistry Angewandte Chemie International Edition 55: 9422–9426, Angewandte Chemie 128: 9569 – 9574. Mondal M., Unver M.Y., Pal A., Bakker M., Berrier S.P., Hirsch A.K.H. (2016) Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and -Optimization of Inhibitors of the Aspartic Protease Endothiapepsin Chemistry – A European Journal 22: 14826 - 14830. Monjas L., Swier L.J.Y.M., de Voogd A.R., Oudshoorn R.C., Guskov A., Hirsch A.K.H., Slotboom D.J. (2016) Design and synthesis of thiamine analogues to study their binding to the ECF transporter for thiamine in bacteria Medicinal Chemistry Communications 7: 966 – 971. Hartman A.M., Mondal M., Radeva N., Klebe G., Hirsch A.K.H. (2015) Structure-Based Optimization of Inhibitors of the Aspartic Protease Endothiapepsin International Journal of Molecular Sciences 16: 19184 – 19194. Hirsch A.K.H. (2015) Supramolecular Chemistry … and Beyond Angewandte Chemie International Edition 54: 11013 – 11014, Angewandte Chemie 127: 11165 - 11166. Huizing A.P., Mondal M., Hirsch A.K.H. (2015) Fighting Malaria: Structure-Guided Discovery of Nonpeptidomimetic Plasmepsin Inhibitors Journal of Medicinal Chemistry 58: 5151 – 5163. Masini T., Lacy B., Monjas L., de Voogd A.R., Iqbal A., Illarionov B., Leeper F.J., Fischer M., Kontoyianni M., Hirsch A.K.H. (2015) Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS Organic & Biomolecular Chemistry 13: 11263 – 11277. Mondal M., Groothuis D.E., Hirsch A.K.H. (2015) Fragment growing exploiting dynamic combinatorial chemistry of inhibitors of the aspartic protease endothiapepsin Medicinal Chemistry Communications 6: 1267 – 1271. Mondal M., Hirsch A.K.H. (2015) Dynamic combinatorial chemistry: a tool to facilitate the identification of inhibitors for protein targets Chemical Society Reviews 44: 2455 – 2488. Monjas L., Hirsch A.K.H. (2015) Harnessing dynamic combinatorial chemistry in the search for new ligands for protein targets Future Medicinal Chemistry 7: 2095 – 2098.

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Monjas L., Swier L.J.Y.M., de Voogd A.R., Gustov A., Slotboom D.J., Hirsch A.K.H. (2015) Structure-Based Design of Potent Small-Molecule Binders to the S-Component of the ECF-transporter for Thiamine ChemBioChem 16: 819 – 826. Wieczorek S., Vigne S., Masini T., Ponader D., Hartmann L., Hirsch A.K.H., Boerner H.G. (2015) Combinatorial Screening for Specific Drug Solubilizers with Switchable Release Profiles Macromolecular Bioscience 15: 82 – 89.

Hirsch A.K.H., Reutenauer P., Le Moignan M., Harrowfield J.M., Ulrich S., Jarowski P.D., Lehn J.M. (2014) Theoretical and Structural Analysis of Long C–C Bonds in the Adducts of Polycyanoethylene and Anthracene Derivatives and Their Connection to the Reversibility of Dynamic Diels–Alder Reactions Chemistry – A European Journal 20: 1073 – 1080. Hirsch A.K.H., Sirlin C., Harrowfield J.M., Lehn J.M. (2014) A doubly hermaphroditic chiral crown ether CrystEngComm 16: 5984 – 5988. Masini T., Hirsch A.K.H. (2014) Development of Inhibitors of the 2C-Methyl-D-erythritol 4-Phosphate (MEP) Pathway Enzymes as Potential Anti-Infective Agents Journal of Medicinal Chemistry 57: 9740 – 9763. Masini T., Kurz J., Kroezen B.S., Illarionov B., Fischer M., Griesinger C., Hirsch A.K.H. (2014) De novo fragment-based design of inhibitors of DXS guided by spin-diffusion-based NMR spectroscopy Chemical Science 5: 3543 – 3551. Mondal M., Radeva N., Köster H., Park A., Potamitis C., Zervou M., Klebe G., Hirsch A.K.H. (2014) Structure-Based Design of Novel Inhibitors of the Aspartic Protease Endothiapepsin Exploiting Dynamic Combinatorial Chemistry Angewandte Chemie International Edition 53: 3259 – 3263, Angewandte Chemie 126: 3324 – 3328.

Scheepstra M., Nieto L., Hirsch A.K.H., Fuchs S., Leysen S., Lam C.V., in het Panhuis L., van Boeckel C.A.A., Wienk H., Boelens R., Ottmann C., Milroy L.G., Brunsveld L. (2014) A Natural-Product Switch for a Dynamic Protein Interface Angewandte Chemie International Edition 53: 6443 – 6448, Angewandte Chemie 126: 6561 – 6566. Geerdink D., ter Horst B., Hirsch A.K.H., Gilleron M., Puzo G., Lepore M., Mori L., de Libero G., Minnaard A.J. (2013) Total synthesis, stereochemical elucidation and biological evaluation of Ac2SGL; a 1,3-methyl branched sulfoglycolipid from Mycobacterium tuberculosis Chemical Science 4: 709 – 716. Masini T., Kroezen B.S., Hirsch A.K.H. (2013) Druggability of the enzymes of the non-mevalonate-pathway Drug Discovery Today 18: 1256 – 1262. Mombelli P., Le Chapelain C., Munzinger N., Joliat E., Illarionov B., Schweizer W.B., Hirsch A.K.H., Fischer M., Bacher A., Diederich F. (2013) Imidazole- and Benzimidazole-Based Inhibitors of the Kinase IspE: Targeting the Substrate-Binding Site and the Triphosphate-Binding Loop of the ATP Site European Journal of Organic Chemistry 6: 1068 – 1079. Wieczorek S., Krause E., Hackbarth S., Röder B., Hirsch A.K.H., Börner H.G. (2013) Exploiting Specific Interactions toward Next-Generation Polymeric Drug Transporters Journal of the American Chemical Society 135: 1711 – 1714.

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Werner B., *Kalesse M. (2017) Pinacol Coupling Strategy for the Construction of the

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*Witte S.N.R., Hug J.J., *Géraldy M.N.E., *Müller R., *Kalesse M. (2017) Biosynthesis and Total

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Biosynthesis, and Synthesis of Antalid, a Secondary Metabolite from Polyangium species Organic

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Bluhm N., *Kalesse M. (2015) Synthesis of a C20-Deoxygenated Spirangien Derivative for Target

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*Bruns N., *Collisi W., *Bernecker S., *Stadler M., Richter C., Schwalbe H., *Kalesse M. (2015)

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Naini A., Fohrer J., *Kalesse M. (2015) The Synthesis of Desepoxy-Isotedanolide - A Potential

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*Gieseler M.T., *Kalesse M. (2014) Synthesis of angiolam A Organic Letters 16: 548 - 551.

*Hartmann O., *Kalesse M. (2014) The structure elucidation and total synthesis of β-lipomycin

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Held J., Gebru T., *Kalesse M., *Jansen R., *Gerth K., *Müller R., Mordmüller B. (2014) Antimalarial

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*Kalesse M., Cordes M., Symkenberg G., Lu H.-H. (2014) The vinylogous Mukaiyama aldol reaction

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*Castoldi A., Herr C., Niederstraßer J., *Labouta H.I., *Melero A., *Gordon S., *Schneider-Daum N., Bals R., Lehr C.-M. (2017) Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections European Journal of Pharmaceutics and Biopharmaceutics 118: 62 - 67. Ernst M., John T., Guenther M., Wagner C., Schaefer U.F., *Lehr C.-M. (2017) A Model for the Transient Subdiffusive Behavior of Particles in Mucus Biophysical Journal 112: 172 - 179. Gross A., Torge A., Schaefer U.F., Schneider M., *Lehr C.-M., Wagner C. (2017) A foam model highlights the differences of the macro- and microrheology of respiratory horse mucus Journal of the Mechanical Behavior of Biomedical Materials 71: 216 - 222. Günday Türeli N., Torge A., *Juntke J., Schwarz B.C., *Schneider-Daum N., Türeli A.E., *Lehr C.-M., Schneider M. (2017) Ciprofloxacin-loaded PLGA nanoparticles against cystic fibrosis P. aeruginosa lung infections European Journal of Pharmaceutics and Biopharmaceutics 117: 363 - 371. *Hittinger M., *Schneider-Daum N., *Lehr C.-M. (2017) Cell and tissue-based in vitro models for improving the development of oral inhalation drug products European Journal of Pharmaceutics and Biopharmaceutics 118: 73 - 78. Melero A., *Draheim C., *Hansen S., Giner E., Carreras J.J., Talens-Visconti R., Garrigues T.M., Peris J.E., Recio M.C., Giner R., *Lehr C.-M. (2017) Targeted delivery of Cyclosporine A by polymeric nanocarriers improves the therapy of inflammatory bowel disease in a relevant mouse model European Journal of Pharmaceutics and Biopharmaceutics 119: 361 - 371. *Murgia X., *Loretz B., *Hartwig O., Hittinger M., *Lehr C.-M. (2017) The role of mucus on drug transport and its potential to affect therapeutic outcomes Advanced Drug Delivery Reviews doi: 10.1016/j.addr.2017.10.009. *Murgia X., *Yasar H., *Carvalho-Wodarz C., *Loretz B., *Gordon S., Schwarzkopf K., Schaefer U., *Lehr C.-M. (2017) Modelling the bronchial barrier in pulmonary drug delivery: A human bronchial epithelial cell line supplemented with human tracheal mucus European Journal of Pharmaceutics and Biopharmaceutics 118: 79 - 88. Nickel S., Selo M.A., Fallack J., Clerkin C.G., Huwer H., *Schneider-Daum N., *Lehr C.-M., Ehrhardt C. (2017) Expression and Activity of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Distal Lung Epithelial Cells In Vitro Pharmaceutical Research 34: 2477 - 2487. Rigo L.A., *Carvalho-Wodarz C.S., Pohlmann A.R., Guterres S.S., *Schneider-Daum N., *Lehr C.-M., Beck R.C.R. (2017) Nanoencapsulation of a glucocorticoid improves barrier function and anti-inflammatory effect on monolayers of pulmonary epithelial cell lines European Journal of Pharmaceutics and Biopharmaceutics 119: 1 - 10. Schaefer U.F., Selzer D., *Hansen S., *Lehr C.-M. (2017) Human native and reconstructed skin preparations for in vitro penetration and permeation studies In: Dragicevic N., Maibach H.I. (eds.) Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin. Springer, Berlin, Heidelberg. pp. 185 - 203. Selzer D., Schaefer U.F., *Lehr C.-M., *Hansen S. (2017) Basic mathematics in skin absorption In: Dragicevic N., Maibach H.I. (eds.) Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin. Springer, Berlin, Heidelberg. pp. 3 - 25.

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biologically active compounds PLoS ONE 11: e0149216.

Axenov-Gribanov D., *Rebets Y., *Tokovenko B., Voytsekhovskaya I., Timofeyev M., *Luzhetskyy A.

(2016) The isolation and characterization of actinobacteria from dominant benthic

macroinvertebrates endemic to Lake Baikal Folia Microbiologica 61: 159 - 168.

Axenov-Gribanov D.V., Voytsekhovskaya I.V., *Rebets Y.V., *Tokovenko B.T., Penzina T.A., Gornostay

T.G., Adelshin R.V., Protasov E.S., *Luzhetskyy A.N., Timofeyev M.A. (2016) Actinobacteria possessing

antimicrobial and antioxidant activities isolated from the pollen of scots pine (Pinus sylvestris) grown

on the Baikal shore Antonie van Leeuwenhoek, International Journal of General and Molecular


*Bilyk O., *Brötz E., *Tokovenko B., Bechthold A., Paululat T., *Luzhetskyy A. (2016) New

Simocyclinones: Surprising Evolutionary and Biosynthetic Insights ACS Chemical Biology 11: 241 -

250.

*Bilyk O., *Luzhetskyy A. (2016) Metabolic engineering of natural product biosynthesis in

actinobacteria Current Opinion in Biotechnology 42: 98 - 107.

*Bilyk O., Sekurova O.N., Zotchev S.B., *Luzhetskyy A. (2016) Cloning and heterologous expression of

the grecocycline biosynthetic gene cluster PLoS ONE 11: e0158682.

*Horbal L., *Luzhetskyy A. (2016) Dual control system - A novel scaffolding architecture of an

inducible regulatory device for the precise regulation of gene expression Metabolic Engineering 37:

11 - 23.

Horbal L., Ostash B., *Luzhetskyy A., Walker S., Kalinowski J., Fedorenko V. (2016) A gene cluster for

the biosynthesis of moenomycin family antibiotics in the genome of teicoplanin producer

Actinoplanes teichomyceticus Applied Microbiology and Biotechnology 100: 7629 - 7638.

*Manderscheid N., Bilyk B., Busche T., Kalinowski J., Paululat T., Bechthold A., Petzke L., *Luzhetskyy

A. (2016) An influence of the copy number of biosynthetic gene clusters on the production level of

antibiotics in a heterologous host Journal of Biotechnology 232: 110 - 117.

*Myronovskyi M., *Brötz E., *Rosenkränzer B., *Manderscheid N., *Tokovenko B., *Rebets Y.,

*Luzhetskyy A. (2016) Generation of new compounds through unbalanced transcription of

landomycin A cluster Applied Microbiology and Biotechnology 100: 9175 - 9186.

*Myronovskyi M., *Luzhetskyy A. (2016) Native and engineered promoters in natural product

discovery Natural Product Reports 33: 1006 - 1019.

Yushchuk O., Ostash B., Pham T.H., *Luzhetskyy A., Fedorenko V., Truman A.W., Horbal L. (2016)

Characterization of the Post-Assembly Line Tailoring Processes in Teicoplanin Biosynthesis ACS


*Lopatniuk M., Ostash B., Makitrynskyy R., Walker S., *Luzhetskyy A., Fedorenko V. (2015) Testing

the utility of site-specific recombinases for manipulations of genome of moenomycin producer

Streptomyces ghanaensis ATCC14672 Journal of Applied Genetics 56: 547 - 550.

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*Raju R., Gromyko O., Fedorenko V., *Luzketskyy A., *Müller R. (2015) Albaflavenol B, a new

sesquiterpene isolated from the terrestrial actinomycete, Streptomyces sp. Journal of Antibiotics 68:

286 - 288.

*Rebets Y., *Brotz E., *Manderscheid N., *Tokovenko B., *Myronovskyi M., Metz P., Petzke L.,

*Luzhetskyy A. (2015) Insights into the pamamycin biosynthesis Angewandte Chemie - International

Edition 54: 2280 - 2284.

Medema M.H., Kottmann R., Yilmaz P., Cummings M., Biggins J.B., Blin K., de Bruijn I., Chooi Y.H.,

Claesen J., Coates R.C., Cruz-Morales P., *Duddela S., Düsterhus S., Edwards D.J., Fewer D.P., Garg N.,

Geiger C., Gomez-Escribano J.P., Greule A., Hadjithomas M., Haines A.S., Helfrich E.J., Hillwig M.L.,

Ishida K., Jones A.C., Jones C.S., *Jungmann K., Kegler C., Kim H.U., Kötter P., *Krug D., Masschelein J.,

Melnik A.V., Mantovani S.M., Monroe E.A., Moore M., Moss N., Nützmann H.W., Pan G., Pati A.,

Petras D., Reen FJ., Rosconi F., Rui Z., Tian Z., Tobias N.J., Tsunematsu Y., Wiemann P., Wyckoff E.,

Yan X., Yim G., Yu F., Xie Y., Aigle B., Apel A.K., Balibar C.J., Balskus E.P., Barona-Gómez F., Bechthold

A., Bode H.B., Borriss R., Brady S.F., Brakhage A.A., Caffrey P., Cheng Y.Q., Clardy J., Cox R.J., De Mot

R., Donadio S., Donia M.S., van der Donk W.A., Dorrestein P.C., Doyle S., Driessen A.J., Ehling-Schulz

M., Entian K.D., Fischbach M.A., Gerwick L., Gerwick W.H., Gross H., Gust B., Hertweck C., Höfte M.,

Jensen S.E., Ju J., Katz L., Kaysser L., Klassen J.L., Keller N.P., Kormanec J., Kuipers O.P., Kuzuyama T.,

Kyrpides N.C., Kwon H.J., Lautru S., Lavigne R., Lee C.Y., Linquan B., Liu X., Liu W., *Luzhetskyy A.,

Mahmud T., Mast Y., Méndez C., Metsä-Ketelä M., Micklefield J., Mitchell D.A., Moore B.S., Moreira

L.M., *Müller R., Neilan B.A., Nett M., Nielsen J., O'Gara F., Oikawa H., Osbourn A., Osburne M.S.,

Ostash B., Payne S.M., Pernodet J.L., Petricek M., Piel J., Ploux O., Raaijmakers J.M., Salas J.A.,

Schmitt E.K., Scott B., Seipke R.F., Shen B., Sherman D.H., Sivonen K., Smanski M.J., Sosio M.,

Stegmann E., Süssmuth R.D., Tahlan K., Thomas C.M., Tang Y., Truman A.W., Viaud M., Walton J.D.,

Walsh C.T., Weber T., van Wezel G.P., Wilkinson B., Willey J.M., Wohlleben W., Wright G.D., Ziemert

N., Zhang C., Zotchev S.B., Breitling R., Takano E., Glöckner F.O. (2015) Minimum Information about a

Biosynthetic Gene cluster Nature Chemical Biology 11: 625 - 631.

Ostash B., Yushchuk O., Tistechok S., Mutenko H., Horbal L., Muryn A., Dacyuk Y., Kalinowski J.,

*Luzhetskyy A., Fedorenko V. (2015) The adpA-like regulatory gene from Actinoplanes

teichomyceticus: in silico analysis and heterologous expression World Journal of Microbiology and

Biotechnology 31: 1297 - 1301.

Wardecki T., *Brötz E., De Ford C., Von Loewenich F.D., *Rebets Y., *Tokovenko B., *Luzhetskyy A.,

Merfort I. (2015) Endophytic Streptomyces in the traditional medicinal plant Arnica montana L.:

Secondary metabolites and biological activity Antonie van Leeuwenhoek, International Journal of

General and Molecular Microbiology 108: 391 - 402.

*Bilyk B., *Luzhetskyy A. (2014) Unusual site-specific DNA integration into the highly active pseudo-

attB of the Streptomyces albus J1074 genome Applied Microbiology and Biotechnology 98: 5095 -

5104.

*Brotz E., *Bilyk O., *Kroger S., Paululat T., Bechthold A., *Luzhetskyy A. (2014) Amycomycins C and

D, new angucyclines from Kitasatospora sp. Tetrahedron Letters 55: 5771 - 5773.

*Horbal L., Fedorenko V., *Luzhetskyy A. (2014) Novel and tightly regulated resorcinol and cumate-

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inducible expression systems for Streptomyces and other actinobacteria Applied Microbiology and


Horbal L., Kobylyanskyy A., Truman A.W., Zaburranyi N., Ostash B., *Luzhetskyy A., Marinelli F.,

Fedorenko V. (2014) The pathway-specific regulatory genes, tei15* and tei16*, are the master

switches of teicoplanin production in Actinoplanes teichomyceticus Applied Microbiology and


Lopatniuk M., Ostash B., *Luzhetskyy A., Walker S., Fedorenko V. (2014) Generation and study of the

strains of streptomycetes-heterologous hosts for the production of moenomycin Russian Journal of

Genetics 50: 360 - 365.

*Myronovskyi M., *Rosenkranzer B., *Luzhetskyy A. (2014) Iterative marker excision system Applied


*Myronovskyi M., *Tokovenko B., *Brotz E., Ruckert C., Kalinowski J., *Luzhetskyy A. (2014) Genome

rearrangements of Streptomyces albus J1074 lead to the carotenoid gene cluster activation Applied


Präg A., Grüning B.A., Häckh M., Lüdeke S., Wilde M., *Luzhetskyy A., Richter M., Luzhetska M.,

Günther S., Müller M. (2014) Regio- and stereoselective intermolecular oxidative phenol coupling in

Streptomyces Journal of the American Chemical Society 136: 6195 - 6198.

*Raju R., Gromyko O., Andriy B., Fedorenko V., *Luzhetskyy A., *Müller R. (2014) Oleamycins A and

B: New antibacterial cyclic hexadepsipeptides isolated from a terrestrial Streptomyces sp. Journal of

Antibiotics 67: 339 - 343.

*Rebets Y., *Brotz E., *Tokovenko B., *Luzhetskyy A. (2014) Actinomycetes biosynthetic potential:

How to bridge in silico and in vivo? Journal of Industrial Microbiology and Biotechnology 41: 387 -

402.

*Rebets Y., *Tokovenko B., *Lushchyk I., Rückert C., *Zaburannyi N., Bechthold A., Kalinowski J.,

*Luzhetskyy A. (2014) Complete genome sequence of producer of the glycopeptide antibiotic

Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of Pseudonocardiaceae

BMC Genomics 15: 885.

*Zaburannyi N., Rabyk M., Ostash B., Fedorenko V., *Luzhetskyy A. (2014) Insights into naturally

minimised Streptomyces albus J1074 genome BMC Genomics 15: 97.

*Bilyk B., Weber S., *Myronovskyi M., *Bilyk O., Petzke L., *Luzhetskyy A. (2013) In vivo random

mutagenesis of streptomycetes using mariner-based transposon Himar1 Applied Microbiology and


*Horbal L., Fedorenko V., Bechthold A., *Luzhetskyy A. (2013) A transposon-based strategy to

identify the regulatory gene network responsible for landomycin e biosynthesis FEMS Microbiology

Letters 342: 138 - 146.

Horbal L., Kobylyanskyy A., Yushchuk O., Zaburannyi N., *Luzhetskyy A., Ostash B., Marinelli F.,

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Fedorenko V. (2013) Evaluation of heterologous promoters for genetic analysis of Actinoplanes

teichomyceticus-Producer of teicoplanin, drug of last defense Journal of Biotechnology 168: 367 -

372.

*Myronovskyi M., *Luzhetskyy A. (2013) Genome engineering in actinomycetes using site-specific

recombinases Applied Microbiology and Biotechnology 97: 4701 - 4712.

*Myronovskyi M., *Tokovenko B., *Manderscheid N., Petzke L., *Luzhetskyy A. (2013) Complete

genome sequence of Streptomyces fulvissimus Journal of Biotechnology 168: 117 - 118.

Ostash B., Campbell J., *Luzhetskyy A., Walker S. (2013) MoeH5: A natural glycorandomizer from the

moenomycin biosynthetic pathway Molecular Microbiology 90: 1324 - 1338.

*Raju R., Gromyko O., Fedorenko V., *Herrmann J., *Luzhetskyy A., *Müller R. (2013) Rubimycinone

A, a new anthraquinone from a terrestrial Streptomyces sp. Tetrahedron Letters 54: 900 - 902.

*Raju R., Gromyko O., Fedorenko V., *Luzhetskyy A., *Müller R. (2013) Oleaceran: A Novel

Spiro[isobenzofuran-1,2'-naptho[1,8-bc]furan] Isolated from a Terrestrial Streptomyces sp Organic

Letters 15: 3487 - 3489.

*Raju R., Gromyko O., Fedorenko V., *Luzhetskyy A., *Müller R. (2013) Lorneic acids C and D, new

trialkyl-substituted aromatic acids isolated from a terrestrial Streptomyces sp. Journal of Antibiotics

66: 347 - 349.

Siegl T., *Tokovenko B., *Myronovskyi M., *Luzhetskyy A. (2013) Design, construction and

characterisation of a synthetic promoter library for fine-tuned gene expression in actinomycetes

Metabolic Engineering 19: 98 - 106.

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Müller, Rolf

*Hoffmann M., *Auerbach D., *Panter F., *Hoffmann T., Dorrestein P.C., *Müller R. (2018) Homospermidine Lipids: A Compound Class Specifically Formed during Fruiting Body Formation of Myxococcus xanthus DK1622 ACS Chemical Biology 13: 273–280. *Surup F., Viehrig K.*, Rachid S.*, Plaza A.*, Maurer C.K.*, *Hartmann R.W., *Müller R. (2018) Crocadepsins-Depsipeptides from the Myxobacterium Chondromyces crocatus Found by a Genome Mining Approach ACS Chemical Biology 13: 267–272. *Awal R.P., *Garcia R., *Gemperlein K.,* Wink J., Kunwar B., Parajuli N., *Müller R. (2017) Vitiosangium cumulatum gen. nov., sp. nov. and Vitiosangium subalbum sp. nov., soil myxobacteria, and emended descriptions of the genera Archangium and Angiococcus, and of the family Cystobacteraceae International Journal of Systematic and Evolutionary Microbiology 67: 1422 - 1430. Bartel K., Winzi M., Ulrich M., Koeberle A., Menche D., Werz O., *Müller R., Guck J., Vollmar A.M., von Schwarzenberg K. (2017) V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - A new option for HCC therapy Oncotarget 8: 9476 - 9487. *Beckmann A., *Hüttel S., *Schmitt V., *Müller R., *Stadler M. (2017) Optimization of the biotechnological production of a novel class of anti-MRSA antibiotics from Chitinophaga sancti Microbial Cell Factories 16: 143. *Bian X., Tang B., Yu Y., *Tu Q., Gross F., Wang H., Li A., Fu J., Shen Y., Li Y.-Z., Stewart A.F., Zhao G., Ding X., *Müller R., Zhang Y. (2017) Heterologous Production and Yield Improvement of Epothilones in Burkholderiales Strain DSM 7029 ACS Chemical Biology 12: 1805 - 1812. Bihelovic F., Stichnoth D., *Surup F., *Müller R., Trauner D. (2017) Total Synthesis of Crocagin A Angewandte Chemie - International Edition 56: 12848 - 12851. *Bock T., *Luxenburger E., *Hoffmann J., Schütza V., Feiler C., *Müller R., *Blankenfeldt W. (2017) AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus Angewandte Chemie - International Edition 56: 9986 - 9989. *Bock T., *Volz C., *Hering V., *Scrima A., *Müller R., *Blankenfeldt W. (2017) The AibR-isovaleryl coenzyme A regulator and its DNA binding site - a model for the regulation of alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus Nucleic acids research 45: 2166 - 2178. Bruns H., Herrmann J., *Müller R., *Wang H., *Wagner Döbler I., Schulz S. (2017) Oxygenated N-Acyl Alanine Methyl Esters (NAMEs) from the Marine Bacterium Roseovarius tolerans EL-164 Journal of Natural Products. doi: 10.1021/acs.jnatprod.7b00757. Cheng B., *Müller R., Trauner D. (2017) Total Syntheses of Cystobactamids and Structural Confirmation of Cystobactamid 919-2 Angewandte Chemie - International Edition 56: 12755 - 12759. *de Mello Martins A.G.G., *Allegretta G., Unteregger G., *Haupenthal J., *Eberhard J., *Hoffmann M., van der Zee J.A., Junker K., Stöckle M., *Müller R., *Hartmann R.W., Ohlmann C.-H. (2017) CYP17A1-independent production of the neurosteroid-derived 5a-pregnan-3ß,6a-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone Journal of Steroid Biochemistry and Molecular Biology 174: 183 - 191.

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*Donner J., *Reck M., Bunk B., *Jarek M., *App C.B., Meier-Kolthoff J.P., Overmann J., *Müller R., Kirschning A., *Wagner-Döbler I. (2017) The Biofilm Inhibitor Carolacton Enters Gram-Negative Cells: Studies Using a TolC-Deficient Strain of Escherichia coli mSphere 2: e00375-17. *Fu C., *Auerbach D., *Li Y., *Scheid U., *Luxenburger E., *Garcia R., *Irschik H., *Müller R. (2017) Solving the Puzzle of One-Carbon Loss in Ripostatin Biosynthesis Angewandte Chemie - International Edition 56: 2192 - 2197. *Fu C., *Sikandar A., *Donner J., *Zaburannyi N., *Herrmann J., *Reck M., *Wagner-Döbler I., *Koehnke J., *Müller R. (2017) The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD Nature Communications 8: 1529. *Gemperlein K., *Hoffmann M., Huo L., Pilak P., Petzke L., *Müller R., *Wenzel S.C. (2017) Synthetic biology approaches to establish a heterologous production system for coronatines Metabolic Engineering 44: 213 - 222. *Herrmann J., *Fayad A.A., *Müller R. (2017) Natural products from myxobacteria: Novel metabolites and bioactivities Natural Product Reports 34: 135 - 160. *Herrmann J., Rybniker J., *Müller R. (2017) Novel and revisited approaches in antituberculosis drug discovery Current Opinion in Biotechnology 48: 94 - 101. *Hüttel S., *Testolin G., *Herrmann J., Planke T., Gille F., Moreno M., *Stadler M., *Brönstrup M., Kirschning A., *Müller R. (2017) Discovery and Total Synthesis of Natural Cystobactamid Derivatives with Superior Activity against Gram-Negative Pathogens Angewandte Chemie - International Edition 56: 12760 - 12764. *Kjaerulff L., *Raju R., *Panter F., *Scheid U., *Garcia R., *Herrmann J., *Müller R. (2017) Pyxipyrrolones: Structure Elucidation and Biosynthesis of Cytotoxic Myxobacterial Metabolites Angewandte Chemie - International Edition 56: 9614 - 9618. *Kjaerulff L., *Sikandar A., *Zaburannyi N., *Adam S., *Herrmann J., *Koehnke J., *Müller R. (2017) Thioholgamides: Thioamide-Containing Cytotoxic RiPP Natural Products ACS Chemical Biology 12: 2837 - 2841. *Lukat P., *Katsuyama Y., *Wenzel S., *Binz T., König C., *Blankenfeldt W., *Brönstrup M., *Müller R. (2017) Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity Chemical Science 8: 7521 - 7527. Merk H., Messer P., Ardelt M.A., Lamb D.C., Zahler S., *Müller R., Vollmar A.M., Pachmayr J. (2017) Inhibition of the V-ATPase by Archazolid A: A new strategy to inhibit EMT Molecular Cancer Therapeutics 16: 2329 - 2339. MontesVidal D., von Rymon-Lipinski A.-L., Ravella S., Groenhagen U., *Herrmann J., *Zaburannyi N., Zarbin P.H.G., Varadarajan A.R., Ahrens C.H., Weisskopf L., *Müller R., Schulz S. (2017) Long-Chain Alkyl Cyanides: Unprecedented Volatile Compounds Released by Pseudomonas and Micromonospora Bacteria Angewandte Chemie - International Edition 56: 4342 - 4346. Moradi A., Ebrahimipour G.H., *Mohr K.I., Kämpfer P., Glaeser S.P., *Hennessen F., *Gemperlein K., *Awal R.P., *Wolf C., *Müller R., *Wink J. (2017) Racemicystis persica sp. nov., a myxobacterium from soil International Journal of Systematic and Evolutionary Microbiology 67: 472 - 478.

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Pergola C., Schubert K., Pace S., Ziereisen J., Nikels F., Scherer O., *Hüttel S., Zahler S., Vollmar A.M., Weinigel C., Rummler S., *Müller R., Raasch M., Mosig A., Koeberle A., Werz O. (2017) Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy Scientific Reports 7: 41434. *Rox K., *Rohde M., *Chhatwal G.S., *Müller R. (2017) Disorazoles Block Group A Streptococcal Invasion into Epithelial Cells Via Interference with the Host Factor Ezrin Cell Chemical Biology 24: 159 - 170. Schmidt W., Jones P.G., *Herrmann J., *Müller R., Schulz S. (2017) An Unprecedented Octahydro-3H-oxeto[2,3,4-ij]isochromene Ring System Formed by a Trichloromethyl-Anion-Induced Reaction Cascade Synlett 28: 467 - 470. *Sucipto H., Pogorevc D.*, Luxenburger E.*, Wenzel S.C.*, Müller R.* (2017) Heterologous production of myxobacterial a-pyrone antibiotics in Myxococcus xanthus Metabolic Engineering 44: 160 - 170. Thomas L., Rao Z., Gerstmeier J., Raasch M., Weinigel C., Rummler S., Menche D., *Müller R., Pergola C., Mosig A., Werz O. (2017) Selective upregulation of TNFα expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase Biochemical Pharmacology 130: 71 - 82. *Viehrig K., *Surup F., *Volz C., *Herrmann J., *AbouFayad A., *Adam S., *Köhnke J., Trauner D., *Müller R. (2017) Structure and Biosynthesis of Crocagins: Polycyclic Postranslationally Modified Ribosomal Peptides from Chondromyces crocatus Angewandte Chemie - International Edition 56: 7407 - 7410. *von Tesmar A., *Hoffmann M., *Pippel J., *Fayad A.A., *Dausend-Werner S., Bauer A., *Blankenfeldt W., *Müller R. (2017) Total Biosynthesis of the Pyrrolo[4,2]benzodiazepine Scaffold Tomaymycin on an In Vitro Reconstituted NRPS System Cell Chemical Biology 24: 1216 - 1227. *Wagner S., *Hauck D., *Hoffmann M., *Sommer R., *Joachim I., *Müller R., Imberty A., Varrot A., *Titz A. (2017) Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging Angewandte Chemie - International Edition 56: 16559 - 16564. Wang H., Li Z., Jia R., Yin J., Li A., Xia L., Yin Y., *Müller R., Fu J., Stewart A.F., Zhang Y. (2017) ExoCET: exonuclease in vitro assembly combined with RecET recombination for highly efficient direct DNA cloning from complex genomes Nucleic Acids Research doi: 10.1093/nar/gkx1249. Wang L.L., Candito D., Dräger G., *Herrmann J., *Müller R., Kirschning A. (2017) Harnessing a p-Quinone Methide Intermediate in the Biomimetic Total Synthesis of the Highly Active Antibiotic 20-Deoxy-Elansolid B1 Chemistry - A European Journal 23: 5291 - 5298. *Witte S.N.R., Hug J.J., *Géraldy M.N.E., *Müller R., *Kalesse M. (2017) Biosynthesis and Total Synthesis of Pyrronazol B: a Secondary Metabolite from Nannocystis pusilla Chemistry - A European Journal 23: 15917 - 15921. *Awal R.P., *Garcia R., *Müller R. (2016) Racemicystis crocea gen. nov., sp. nov., a soil myxobacterium in the family Polyangiaceae International Journal of Systematic and Evolutionary Microbiology 66: 2389 - 2395. Beck S., Henß L., Weidner T., *Herrmann J., *Müller R., Chao Y.K., Grimm C., Weber C., Sliva K., Schnierle B.S. (2016) Identification of entry inhibitors of Ebola virus pseudotyped vectors from a

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myxobacterial compound library Antiviral Research 132: 85 - 91. *Bock T., *Kasten J., *Müller R., *Blankenfeldt W. (2016) Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus ChemBioChem : 1257 - 1262. *Bock T., *Müller R., *Blankenfeldt W. (2016) Crystal structure of AibC, a reductase involved in alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus Acta Crystallographica Section F: Structural Biology Communications 72: 652 - 658. *Bock T., *Reichelt J., *Müller R., *Blankenfeldt W. (2016) The Structure of LiuC, a 3-Hydroxy-3-Methylglutaconyl CoA Dehydratase Involved in Isovaleryl-CoA Biosynthesis in Myxococcus xanthus, Reveals Insights into Specificity and Catalysis ChemBioChem : 1658 - 1664. Chen J., Liu M., Liu X., Miao J., *Fu C., Gao H., *Müller R., Zhang Q., Zhang L. (2016) Interrogation of Streptomyces avermitilis for efficient production of avermectins Synthetic and Systems Biotechnology 1: 7 - 16. *Donner J., *Reck M., Bergmann S., Kirschning A., *Müller R., *Wagner-Döbler I. (2016) The biofilm inhibitor Carolacton inhibits planktonic growth of virulent pneumococci via a conserved target Scientific Reports 6: 29677. *Elnakady Y.A., Chatterjee I., Bischoff M., *Rohde M., Josten M., Sahl H.-G., Herrmann M., *Müller R. (2016) Investigations to the antibacterial mechanism of action of kendomycin PLoS ONE 11: e0146165. Essig S., Schmalzbauer B., Bretzke S., Scherer O., Koeberle A., Werz O., *Müller R., Menche D. (2016) Predictive Bioinformatic Assignment of Methyl-Bearing Stereocenters, Total Synthesis, and an Additional Molecular Target of Ajudazol B Journal of Organic Chemistry 81: 1333 - 1357. Fengler V.H.I., Macheiner T., Kessler S.M., Czepukojc B., *Gemperlein K., *Müller R., Kiemer A.K., Magnes C., Haybaeck J., Lackner C., Sargsyan K. (2016) Susceptibility of different mouse wild type strains to develop diet-induced nafld/afld-associated liver disease PLoS ONE 11: e0155163. *Garcia R., *Stadler M., *Gemperlein K., *Müller R. (2016) Aetherobacter fasciculatus gen. nov., sp. nov. and Aetherobacter rufus sp. nov., novel myxobacteria with promising biotechnological applications International Journal of Systematic and Evolutionary Microbiology 66: 928 - 938. *Gemperlein K., Zipf G., Bernauer H.S., *Müller R., *Wenzel S.C. (2016) Metabolic engineering of Pseudomonas putida for production of docosahexaenoic acid based on a myxobacterial PUFA synthase Metabolic Engineering 33: 98 - 108. *Herrmann J., *Lukežic T., *Kling A., *Baumann S., *Hüttel S., Petkovic H., *Müller R. (2016) Strategies for the discovery and development of new antibiotics from natural products: Three case studies Current Topics in Microbiology and Immunology 398: 339 - 363. Jackson D.R., Tu S.S., Nguyen M., Barajas J.F., Schaub A.J., *Krug D., *Pistorius D., Luo R., *Müller R., Tsai S.-C. (2016) Structural Insights into Anthranilate Priming during Type II Polyketide Biosynthesis ACS Chemical Biology 11: 95 - 103. Kessler S.M., Laggai S., Van Wonterg E., *Gemperlein K., *Müller R., Haybaeck J., Vandenbroucke R.E., Ogris M., Libert C., Kiemer A.K. (2016) Transient hepatic overexpression of insulin-like growth factor 2 induces free cholesterol and lipid droplet formation Frontiers in Physiology 7: 147.

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Knapp A., Voget S., Gao R., *Zaburannyi N., Krysciak D., Breuer M., Hauer B., Streit W.R., *Müller R., Daniel R., Jaeger K.-E. (2016) Mutations improving production and secretion of extracellular lipase by Burkholderia glumae PG1 Applied Microbiology and Biotechnology 100: 1265 - 1273. Lee W., Schaefer K., Qiao Y., Srisuknimit V., *Steinmetz H., *Müller R., Kahne D., Walker S. (2016) The Mechanism of Action of Lysobactin Journal of the American Chemical Society 138: 100 - 103. Lohße A., Kolinko I., Raschdorf O., Uebe R., Borg S., Brachmann A., Plitzko J.M., *Müller R., Zhang Y., Schüler D. (2016) Overproduction of magnetosomes by genomic amplification of biosynthesis-related gene clusters in a magnetotactic bacterium Applied and Environmental Microbiology 82: 3032 - 3041. Luniak N., Meiser P., Burkart S., *Müller R. (2016) Heterologous expression of the plant cysteine protease bromelain and its inhibitor in Pichia pastoris Biotechnology Progress 33: 54 - 65. Mann G., Huo L., *Adam S., Nardone B., Vendome J., Westwood N.J., *Müller R., *Koehnke J. (2016) Structure and Substrate Recognition of the Bottromycin Maturation Enzyme BotP ChemBioChem 17: 2286 - 2292. *Maurer C.K., *Fruth M., *Empting M., Avrutina O., *Hoßmann J., *Nadmid S., Gorges J., *Herrmann J., Kazmaier U., *Dersch P., *Müller R., *Hartmann R.W. (2016) Discovery of the first small-molecule CsrA-RNA interaction inhibitors using biophysical screening technologies Future Medicinal Chemistry 8: 931 - 947. Meusel M., Hufsky F., *Panter F., *Krug D., *Müller R., Böcker S. (2016) Predicting the Presence of Uncommon Elements in Unknown Biomolecules from Isotope Patterns Analytical Chemistry 88: 7556 - 7566. *Perin P.M., *Haid S., *Brown R.J., *Doerrbecker J., *Schulze K., Zeilinger C., von Schaewen M., Heller B., Vercauteren K., *Luxenburger E., Baktash Y.M., Vondran F.W., Speerstra S., Awadh A., Mukhtarov F., Schang L.M., Kirschning A., *Müller R., *Guzman C.A., Kaderali L., Randall G., Meuleman P., Ploss A., *Pietschmann T. (2016) Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1 Hepatology 63: 49 - 62. Preisitsch M., Heiden S.E., Beerbaum M., Niedermeyer T.H.J., Schneefeld M., *Herrmann J., Kumpfmüller J., Thürmer A., Neidhardt I., Wiesner C., Daniel R., *Müller R., Bange F.-C., Schmieder P., Schweder T., Mundt S. (2016) Effects of halide ions on the carbamidocyclophane biosynthesis in Nostoc sp. CAVN2 Marine Drugs 14: 21. Preisitsch M., Niedermeyer T.H.J., Heiden S.E., Neidhardt I., Kumpfmüller J., Wurster M., *Harmrolfs K., Wiesner C., Enke H., *Müller R., Mundt S. (2016) Cylindrofridins A-C, Linear Cylindrocyclophane-Related Alkylresorcinols from the Cyanobacterium Cylindrospermum stagnale Journal of Natural Products 79: 106 - 115. Salamanca-Pinzon S.G., Khatri Y., Carius Y., *Keller L., *Müller R., Lancaster C.R., Bernhardt R. (2016) Structure-function analysis for the hydroxylation of Δ4 C21-steroids by the myxobacterial CYP260B1 FEBS Letters 590: 1838 - 1852. Schneider L.S., Ulrich M., Lehr T., Menche D., *Müller R., von Schwarzenberg K. (2016) MDM2 antagonist nutlin-3a sensitizes tumors to V-ATPase inhibition Molecular Oncology 10: 1054 - 1062.

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*Steinmetz H., *Li J., *Fu C., *Zaburannyi N., *Kunze B., *Harmrolfs K., *Schmitt V., *Herrmann J., *Reichenbach H., *Höfle G., *Kalesse M., *Müller R. (2016) Isolation, Structure Elucidation, and (Bio)Synthesis of Haprolid, a Cell-Type-Specific Myxobacterial Cytotoxin Angewandte Chemie - International Edition 55: 10113 - 10117. Tautz T., *Hoffmann J., *Hoffmann T., *Steinmetz H., *Washausen P., *Kunze B., Huch V., Kitsche A., *Reichenbach H., *Höfle G., *Müller R., *Kalesse M. (2016) Isolation, Structure Elucidation, Biosynthesis, and Synthesis of Antalid, a Secondary Metabolite from Polyangium species Organic Letters 18: 2560 - 2563. *Tu Q., *Herrmann J., Hu S., *Raju R., Bian X., Zhang Y., *Müller R. (2016) Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering Scientific Reports 6: 21066. *Tu Q., Yin J., Fu J., *Herrmann J., Li Y., Yin Y., Stewart A.F., *Müller R., Zhang Y. (2016) Room temperature electrocompetent bacterial cells improve DNA transformation and recombineering efficiency Scientific Reports 6: 24648. Wang H., Li Z., Jia R., Hou Y., Yin J., Bian X., Li A., *Müller R., Stewart A.F., Fu J., Zhang Y. (2016) RecET direct cloning and Redaß recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression Nature Protocols 11: 1175 - 1190. Wang M., Carver J.J., Phelan V.V., Sanchez L.M., Garg N., Peng Y., Nguyen D.D., Watrous J., Kapono C.A., Luzzatto-Knaan T., Porto C., Bouslimani A., Melnik A.V., Meehan M.J., Liu W.T., Crüsemann M., Boudreau P.D., Esquenazi E., Sandoval-Calderón M., Kersten R.D., Pace L.A., Quinn R.A., Duncan K.R., Hsu C.C., Floros D.J., Gavilan R.G., Kleigrewe K., Northen T., Dutton R.J., Parrot D., Carlson E.E., Aigle B., Michelsen C.F., Jelsbak L., Sohlenkamp C., Pevzner P., Edlund A., McLean J., Piel J., Murphy B.T., Gerwick L., Liaw C.C., Yang YL., Humpf H.U., Maansson M., Keyzers R.A., Sims A.C., Johnson A.R., Sidebottom A.M., Sedio B.E., Klitgaard A., Larson C.B., Boya P C.A., Torres-Mendoza D., Gonzalez D.J., Silva D.B., Marques L.M., Demarque D.P., Pociute E., O'Neill E.C., Briand E., Helfrich E.J.N., Granatosky E.A., Glukhov E., Ryffel F., Houson H., Mohimani H., Kharbush J.J., Zeng Y., Vorholt J.A., Kurita K.L., Charusanti P., McPhail K.L., Nielsen K.F., Vuong L., Elfeki M., Traxler M.F., Engene N., Koyama N., Vining O.B., Baric R., Silva R.R., Mascuch S.J., Tomasi S., Jenkins S., Macherla V., *Hoffman T., Agarwal V., Williams P.G., Dai J., Neupane R., Gurr J., Rodríguez A.M.C., Lamsa A., Zhang C., Dorrestein K., Duggan B.M., Almaliti J., Allard P.M., Phapale P., Nothias L.F., Alexandrov T., Litaudon M., Wolfender J.L., Kyle J.E., Metz T.O., Peryea T., Nguyen D.T., VanLeer D., Shinn P., Jadhav A., *Müller R., Waters K.M., Shi W., Liu X., Zhang L., Knight R., Jensen P.R., Palsson B.O., Pogliano K., Linington R.G., Gutiérrez M., Lopes N.P., Gerwick W.H., Moore B.S., Dorrestein P.C., Bandeira N. (2016) Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking Nature Biotechnology 34: 828 - 837. Wang Y., *Schnell B., *Baumann S., *Müller R., Begley T.P. (2016) Biosynthesis of branched alkoxy groups: Iterative methyl group alkylation by a cobalamin-dependent radical SAM enzyme Journal of the American Chemical Society 139: 1742 - 1745. Wu H., Wang Y., Yuan L., Mao Y., Wang W., Zhu L., Wu P., Fu C., *Müller R., Weaver D.T., Zhang L., Zhang B. (2016) Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea Synthetic and Systems Biotechnology 1: 39 - 46. *Zaburannyi N., Bunk B., Maier J., Overmann J., *Müller R. (2016) Genome analysis of the fruiting body-forming myxobacterium Chondromyces crocatus reveals high potential for natural product

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biosynthesis Applied and Environmental Microbiology 82: 1945 - 1957. *Bian X., *Plaza A., *Yan F., Zhang Y., *Müller R. (2015) Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide derivatives in vivo Biotechnology and Bioengineering 112: 1343 - 1353. *Bian X., *Plaza A., Zhang Y., *Müller R. (2015) Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety Chemical Science 6: 3154 - 3160. Braig S., Sebastian Schmidt B.U., Stoiber K., Handel C., Möhn T., Werz O., *Müller R., Zahler S., Koeberle A., Käs J.A., Vollmar A.M. (2015) Pharmacological targeting of membrane rigidity: Implications on cancer cell migration and invasion New Journal of Physics 17: 83007. Franke J., Bock M., Dehn R., Fohrer J., Mhaske S.B., Migliorini A., Kanakis A.A., *Jansen R., *Herrmann J., *Müller R., Kirschning A. (2015) Total and semi-syntheses of antimicrobial thuggacin derivatives Chemistry - A European Journal 21: 4272 - 4284. *Fu C., *Keller L., Bauer A., *Brönstrup M., Froidbise A., Hammann P., *Herrmann J., Mondesert G., Kurz M., Schiell M., Schummer D., Toti L., *Wink J., *Müller R. (2015) Biosynthetic Studies of Telomycin Reveal New Lipopeptides with Enhanced Activity Journal of the American Chemical Society 137: 7692 - 7705. *Jungmann K., *Jansen R., *Gerth K., *Huch V., *Krug D., Fenical W., *Müller R. (2015) Two of a Kind-The Biosynthetic Pathways of Chlorotonil and Anthracimycin ACS Chemical Biology 10: 2480 - 2490. Karmann L., Schultz K., *Herrmann J., *Müller R., Kazmaier U. (2015) Total Syntheses and Biological Evaluation of Miuraenamides Angewandte Chemie - International Edition 54: 4502 - 4507. *Keller L., *Plaza A., Dubiella C., Groll M., Kaiser M., *Müller R. (2015) Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone that Targets the 20S Proteasome Journal of the American Chemical Society 137: 8121 - 8130. Kling A.*, *Lukat P., Almeida D.V., Bauer A., Fontaine E., Sordello S., *Zaburannyi N., *Herrmann J., *Wenzel S.C., Konig C., Ammerman N.C., Barrio M.B., Borchers K., Bordon-Pallier F., *Brönstrup M., Courtemanche G., Gerlitz M., Geslin M., Hammann P., *Heinz D.W., Hoffmann H., Klieber S., Kohlmann M., Kurz M., Lair C., Matter H., Nuermberger E., Tyagi S., Fraisse L., Grosset J.H., Lagrange S., *Müller R.. (2015) Targeting DnaN for tuberculosis therapy using novel griselimycins Science 348: 1106 - 1112. Koutsoudakis G., Romero-Brey I., Berger C., Perez-Vilaro G., *Monteiro Perin P., Vondran F.W.R., *Kalesse M., *Harmrolfs K., *Müller R., Martinez J.P., *Pietschmann T., Bartenschlager R., *Brönstrup M., Meyerhans A., Diez J. (2015) Soraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity Journal of Hepatology 63: 813 - 821. *Kuhnert E., *Surup F., *Herrmann J., Huch V., *Müller R., *Stadler M. (2015) Rickenyls A-E, antioxidative terphenyls from the fungus Hypoxylon rickii (Xylariaceae, Ascomycota) Phytochemistry 118: 68 - 73. Lesnik U., *Lukezic T., Podgorsek A., Horvat J., Polak T., Sala M., Jenko B., *Harmrolfs K., Ocampo-Sosa A., Martinez-Martinez L., Herron P.R., Fujs S., Kosec G., Hunter I.S., *Müller R., Petkovic H. (2015) Construction of a new class of tetracycline lead structures with potent antibacterial activity

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through biosynthetic engineering Angewandte Chemie - International Edition 54: 3937 - 3940. Medema M.H., Kottmann R., Yilmaz P., Cummings M., Biggins J.B., Blin K., de Bruijn I., Chooi Y.H., Claesen J., Coates R.C., Cruz-Morales P., *Duddela S., Düsterhus S., Edwards D.J., Fewer D.P., Garg N., Geiger C., Gomez-Escribano J.P., Greule A., Hadjithomas M., Haines A.S., Helfrich E.J., Hillwig M.L., Ishida K., Jones A.C., Jones C.S., *Jungmann K., Kegler C., Kim H.U., Kötter P., *Krug D., Masschelein J., Melnik A.V., Mantovani S.M., Monroe E.A., Moore M., Moss N., Nützmann H.W., Pan G., Pati A., Petras D., Reen FJ., Rosconi F., Rui Z., Tian Z., Tobias N.J., Tsunematsu Y., Wiemann P., Wyckoff E., Yan X., Yim G., Yu F., Xie Y., Aigle B., Apel A.K., Balibar C.J., Balskus E.P., Barona-Gómez F., Bechthold A., Bode H.B., Borriss R., Brady S.F., Brakhage A.A., Caffrey P., Cheng Y.Q., Clardy J., Cox R.J., De Mot R., Donadio S., Donia M.S., van der Donk W.A., Dorrestein P.C., Doyle S., Driessen A.J., Ehling-Schulz M., Entian K.D., Fischbach M.A., Gerwick L., Gerwick W.H., Gross H., Gust B., Hertweck C., Höfte M., Jensen S.E., Ju J., Katz L., Kaysser L., Klassen J.L., Keller N.P., Kormanec J., Kuipers O.P., Kuzuyama T., Kyrpides N.C., Kwon H.J., Lautru S., Lavigne R., Lee C.Y., Linquan B., Liu X., Liu W., *Luzhetskyy A., Mahmud T., Mast Y., Méndez C., Metsä-Ketelä M., Micklefield J., Mitchell D.A., Moore B.S., Moreira L.M., *Müller R., Neilan B.A., Nett M., Nielsen J., O'Gara F., Oikawa H., Osbourn A., Osburne M.S., Ostash B., Payne S.M., Pernodet J.L., Petricek M., Piel J., Ploux O., Raaijmakers J.M., Salas J.A., Schmitt E.K., Scott B., Seipke R.F., Shen B., Sherman D.H., Sivonen K., Smanski M.J., Sosio M., Stegmann E., Süssmuth R.D., Tahlan K., Thomas C.M., Tang Y., Truman A.W., Viaud M., Walton J.D., Walsh C.T., Weber T., van Wezel G.P., Wilkinson B., Willey J.M., Wohlleben W., Wright G.D., Ziemert N., Zhang C., Zotchev S.B., Breitling R., Takano E., Glöckner F.O. (2015) Minimum Information about a Biosynthetic Gene cluster Nature Chemical Biology 11: 625 - 631. *Mohr K.I., *Volz C., *Jansen R., *Wray V., *Hoffmann J., *Bernecker S., *Wink J., *Gerth K., *Stadler M., *Müller R. (2015) Pinensins: The First Antifungal Lantibiotics Angewandte Chemie - International Edition 54: 11254 - 11258. Moreno M., *Elgaher W.A.M., *Herrmann J., Schlager N., *Hamed M.M., *Baumann S., *Müller R., *Hartmann R.W., Kirschning A. (2015) Synthesis and biological evaluation of cystobactamid 507: A bacterial topoisomerase inhibitor from Cystobacter sp. Synlett 26: 1175 - 1178. *Nadmid S., *Plaza A., *Garcia R., *Müller R. (2015) Cystochromones, Unusual Chromone-Containing Polyketides from the Myxobacterium Cystobacter sp. MCy9104 Journal of Natural Products 78: 2023 - 2028. Preisitsch M., *Harmrolfs K., Pham H.T.L., Heiden S.E., Fussel A., Wiesner C., Pretsch A., Swiatecka-Hagenbruch M., Niedermeyer T.H.J., *Müller R., Mundt S. (2015) Anti-MRSA-acting carbamidocyclophanes H-L from the Vietnamese cyanobacterium Nostoc sp. CAVN2 Journal of Antibiotics 68: 165 - 177. *Raju R., *Mohr K.I., *Bernecker S., *Herrmann J., *Müller R. (2015) Cystodienoic acid: A new diterpene isolated from the myxobacterium Cystobacter sp. Journal of Antibiotics 68: 473 - 475. *Raju R., Gromyko O., Fedorenko V., *Luzketskyy A., *Müller R. (2015) Albaflavenol B, a new sesquiterpene isolated from the terrestrial actinomycete, Streptomyces sp. Journal of Antibiotics 68: 286 - 288. *Sahner J.H., *Sucipto H., *Wenzel S.C., *Groh M., *Hartmann R.W., *Müller R. (2015) Advanced Mutasynthesis Studies on the Natural α-Pyrone Antibiotic Myxopyronin from Myxococcus fulvus ChemBioChem 16: 946 - 953. *Sood S., *Awal R.P., *Wink J., *Mohr K.I., *Rohde M., *Stadler M., Kämpfer P., Glaeser S.P.,

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Schumann P., *Garcia R., *Müller R. (2015) Aggregicoccus edonensis gen. nov., sp. nov., an unusually aggregating myxobacterium isolated from a soil sample International Journal of Systematic and Evolutionary Microbiology 65: 745 - 753. *Sucipto H., *Sahner J.H., *Prusov E., *Wenzel S.C., *Hartmann R.W., *Koehnke J., *Müller R. (2015) In vitro reconstitution of α-pyrone ring formation in myxopyronin biosynthesis Chemical Science 6: 5076 - 5085. *Tang Y., *Frewert S., *Harmrolfs K., *Herrmann J., Karmann L., Kazmaier U., Xia L., Zhang Y., *Müller R. (2015) Heterologous expression of an orphan NRPS gene cluster from Paenibacillus larvae in Escherichia coli revealed production of sevadicin Journal of Biotechnology 194: 112 - 114. Weber T., Blin K., *Duddela S., *Krug D., Kim H.U., Bruccoleri R., Lee S.Y., Fischbach M.A., *Müller R., Wohlleben W., Breitling R., Takano E., Medema M.H. (2015) antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters Nucleic acids research 43: W237 - W243. *Wenzel S.C., Hoffmann H., Zhang J., Debussche L., Haag-Richter S., Kurz M., Nardi F., *Lukat P., *Kochems I., Tietgen H., Schummer D., Nicolas J.-P., Calvet L., Czepczor V., Vrignaud P., Mühlenweg A., Pelzer S., *Müller R., *Brönstrup M. (2015) Production of the Bengamide Class of Marine Natural Products in Myxobacteria: Biosynthesis and Structure-Activity Relationships Angewandte Chemie - International Edition 54: 15560 - 15564. *Yin J., *Hoffmann M., Bian X., *Tu Q., *Yan F., Xia L., Ding X., Stewart A.F., *Müller R., Fu J., Zhang Y. (2015) Direct cloning and heterologous expression of the salinomycin biosynthetic gene cluster from Streptomyces albus DSM41398 in Streptomyces coelicolor A3(2) Scientific Reports 5: 15081. *Yin J., Zhu H., Xia L., Ding X., *Hoffmann T., *Hoffmann M., *Bian X., *Müller R., Fu J., Stewart A.F., Zhang Y. (2015) A new recombineering system for Photorhabdus and Xenorhabdus Nucleic Acids Research 43: e36 - . Zhang S., Schneider L.S., Vick B., Grunert M., Jeremias I., Menche D., *Müller R., Vollmar A.M., Liebl J. (2015) Anti-leukemic effects of the V-ATPase inhibitor Archazolid A Oncotarget 6: 43508 - 43528. *Baumann S., *Herrmann J., *Raju R., *Steinmetz H., *Mohr K.I., *Huttel S., *Harmrolfs K., *Stadler M., *Müller R. (2014) Cystobactamids: Myxobacterial topoisomerase inhibitors exhibiting potent antibacterial activity Angewandte Chemie - International Edition 53: 14605 - 14609. Beck P., Heinemeyer W., Spath A.-L., *Elnakady Y., *Müller R., Groll M. (2014) Interactions of the natural product kendomycin and the 20S proteasome Journal of Molecular Biology 426: 3108 - 3117. *Berod L., *Friedrich C., *Nandan A., *Freitag J., *Hagemann S., *Harmrolfs K., *Sandouk A., *Hesse C., *Castro C.N., Bähre H., Tschirner S.K., Gorinski N., *Gohmert M., *Mayer C.T., *Huehn J., Ponimaskin E., *Abraham W.-R., *Müller R., *Lochner M., *Sparwasser T. (2014) De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells Nature Medicine 20: 1327 - 1333. Bian X.*, Huang F., Wang H., *Klefisch T., *Müller R., Zhang Y. (2014) Heterologous production of glidobactins/luminmycins in Escherichia coli Nissle containing the glidobactin biosynthetic gene cluster from Burkholderia DSM7029 ChemBioChem 15: 2221 - 2224. *Brötz E., *Herrmann J., Wiese J., Zinecker H., Maier A., Kelter G., Imhoff J.F., *Müller R., Paululat T.

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(2014) Synthesis and cytotoxic activity of a small naphthoquinone library: First synthesis of juglonbutin European Journal of Organic Chemistry 2014: 5318 - 5330. Etzbach L., Plaza A., Garcia R., Baumann S., *Müller R. (2014) Cystomanamides: Structure and biosynthetic pathway of a family of glycosylated lipopeptides from myxobacteria Organic Letters 16: 2414 - 2417. Foerster F., Braig S., Moser C., Kubisch R., Busse J., Wagner E., Schmoeckel E., Mayr D., Schmitt S., Huettel S., Zischka H., *Mueller R., Vollmar A.M. (2014) Targeting the actin cytoskeleton: Selective antitumor action via trapping PKC? Cell Death and Disease 5: e1398. *Fruth M., *Plaza A., *Hinsberger S., *Sahner J.H., *Haupenthal J., Bischoff M., *Jansen R., *Müller R., *Hartmann R.W. (2014) Binding mode characterization of novel RNA polymerase inhibitors using a combined biochemical and NMR approach ACS chemical biology 9: 2656 - 2663. *Garcia R., *Gemperlein K., *Müller R. (2014) Minicystis rosea gen. nov., Sp. nov., a polyunsaturated fatty acid-rich and steroid-producing soil myxobacterium International Journal of Systematic and Evolutionary Microbiology 64: 3733 - 3742. *Garcia R., *Müller R. (2014) Family Haliangiaceae In: Rosenberg E., DeLong E.F., Lory S., Stackebrandt E., Thompson F. (eds.) The Prokaryotes 4th Edition. Springer, Berlin/Heidelberg. pp. 173 - 181. *Garcia R., *Müller R. (2014) Family Myxococcaceae In: Rosenberg E., DeLong E.F., Lory S., Stackebrandt E., Thompson F. (eds.) The Prokaryotes 4th Edition. Springer, Berlin/Heidelberg. pp. 191 - 212. . *Garcia R., *Müller R. (2014) Family Nannocystaceae In: Rosenberg E., DeLong E.F., Lory S., Stackebrandt E., Thompson F. (eds.) The Prokaryotes 4th Edition. Springer, Berlin/Heidelberg. pp. 213 - 229. *Garcia R., *Müller R. (2014) Family Phaselicystidaceae In: Rosenberg E., DeLong E.F., Lory S., Stackebrandt E., Thompson F. (eds.) The Prokaryotes 4th Edition. Springer, Berlin/Heidelberg. pp. 239 - 245. *Garcia R., *Müller R. (2014) Family Polyangiaceae In: Rosenberg E., DeLong E.F., Lory S., Stackebrandt E., Thompson F. (eds.) The Prokaryotes 4th Edition. Springer, Berlin/Heidelberg. pp. 247 - 279. *Gemperlein K., *Rachid S., *Garcia R.O., *Wenzel S.C., *Müller R. (2014) Polyunsaturated fatty acid biosynthesis in myxobacteria: Different PUFA synthases and their product diversity Chemical Science 5: 1733 - 1741. Gross P.C., Burkart S.C., *Müller R. (2014) Analytics of the therapeutic peptide aviptadil by sheathless CE-MS and comparison with nanoRP-HPLC-MS Journal of Pharmaceutical and Biomedical Analysis 88: 477 - 482. Hamm R., Chen Y.-R., Seo E.-J., Zeino M., Wu C.-F., *Müller R., Yang N.-S., Efferth T. (2014) Induction of cholesterol biosynthesis by archazolid B in T24 bladder cancer cells Biochemical Pharmacology 91: 18 - 30. Held J., Gebru T., *Kalesse M., *Jansen R., *Gerth K., *Müller R., Mordmüller B. (2014) Antimalarial

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activity of the myxobacterial macrolide chlorotonil A Antimicrobial Agents and Chemotherapy 58: 6378 - 6384. *Hoffmann T., *Krug D., *Hüttel S., *Müller R. (2014) Improving natural products identification through targeted LC-MS/MS in an untargeted secondary metabolomics workflow Analytical Chemistry 86: 10780 - 10788. *Jansen R., *Mohr K.I., *Bernecker S., *Stadler M., *Müller R. (2014) Indothiazinone, an indolyl thiazolyl ketone from a novel myxobacterium belonging to the Sorangiineae Journal of Natural Products 77: 1054 - 1060. *Jansen R., *Sood S., *Mohr K.I., *Kunze B., *Irschik H., *Stadler M., *Müller R. (2014) Nannozinones and sorazinones, unprecedented pyrazinones from myxobacteria Journal of Natural Products 77: 2545 - 2552. *Jansen R., *Sood S., Huch V., *Kunze B., *Stadler M., *Müller R. (2014) Pyrronazols, metabolites from the myxobacteria Nannocystis pusilla and N. exedens, are unusual chlorinated pyrone-oxazole-pyrroles Journal of Natural Products 77: 320 - 326. Katsuyama Y., Li X.-W., *Müller R., Nay B. (2014) Chemically unprecedented biocatalytic (AuaG) retro-[2,3]-wittig rearrangement: A new insight into aurachin B biosynthesis ChemBioChem 15: 2349 - 2352. Kessler S.M., Simon Y., *Gemperlein K., Gianmoena K., Cadenas C., Zimmer V., Pokorny J., Barghash A., Helms V., Van Rooijen N., Bohle R.M., Lammert F., Hengstler J.G., *Mueller R., Haybaeck J., Kiemer A.K. (2014) Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma International Journal of Molecular Sciences 15: 5762 - 5773. Kolinko I., Lohsse A., Borg S., Raschdorf O., Jogler C., *Tu Q., Posfai M., Tompa E., Plitzko J.M., Brachmann A., Wanner G., *Müller R., Zhang Y., Schüler D. (2014) Biosynthesis of magnetic nanostructures in a foreign organism by transfer of bacterial magnetosome gene clusters Nature Nanotechnology 9: 193 - 197. Kreutzer M.F., Kage H., *Herrmann J., Pauly J., Hermenau R., *Müller R., Hoffmeister D., Nett M. (2014) Precursor-directed biosynthesis of micacocidin derivatives with activity against Mycoplasma pneumoniae Organic and Biomolecular Chemistry 12: 113 - 118. *Krug D., *Müller R. (2014) Secondary metabolomics: The impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products Natural Product Reports 31: 768 - 783. Laggai S., Kessler S.M., Boettcher S., Lebrun V., *Gemperlein K., Lederer E., Leclercq I.A., *Mueller R., *Hartmann R.W., Haybaeck J., Kiemer A.K. (2014) The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis Journal of Lipid Research 55: 1087 - 1097. Menhofer M.H., Bartel D., Liebl J., Kubisch R., Busse J., Wagner E., *Müller R., Vollmar A.M., Zahler S. (2014) In vitro and in vivo characterization of the actin polymerizing compound chondramide as an angiogenic inhibitor Cardiovascular Research 104: 303 - 314. Menhofer M.H., Kubisch R., Schreiner L., Zorn M., Foerster F., *Mueller R., Raedler J.O., Wagner E., Vollmar A.M., Zahler S. (2014) The actin targeting compound Chondramide inhibits breast cancer

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metastasis via reduction of cellular contractility PLoS ONE 9: e112542. *Müller R., *Wink J. (2014) Future potential for anti-infectives from bacteria - How to exploit biodiversity and genomic potential International Journal of Medical Microbiology 304: 3 - 13. *Müller S., *Rachid S., *Hoffmann T., *Surup F., *Volz C., *Zaburannyi N., *Müller R. (2014) Biosynthesis of crocacin involves an unusual hydrolytic release domain showing similarity to condensation domains Chemistry and Biology 21: 855 - 865. *Nadmid S., *Plaza A., Lauro G., *Garcia R., Bifulco G., *Müller R. (2014) Hyalachelins A-C, unusual siderophores isolated from the terrestrial myxobacterium Hyalangium minutum Organic Letters 16: 4130 - 4133. *Okanya P.W., *Mohr K.I., *Gerth K., *Kessler W., *Jansen R., *Stadler M., *Müller R. (2014) Hyafurones, hyapyrrolines, and hyapyrones: Polyketides from Hyalangium minutum Journal of Natural Products 77: 1420 - 1429. *Osswald C., *Zaburannyi N., *Burgard C., *Hoffmann T., *Wenzel S.C., *Müller R. (2014) A highly unusual polyketide synthase directs dawenol polyene biosynthesis in Stigmatella aurantiaca Journal of Biotechnology 191: 54 - 63. *Osswald C., Zipf G., Schmidt G., Maier J., Bernauer H.S., *Müller R., *Wenzel S.C. (2014) Modular construction of a functional artificial epothilone polyketide pathway ACS Synthetic Biology 3: 759 - 772. *Plaza A., *Müller R. (2014) Myxobacteria: Chemical diversity and screening strategies In: Osbourn A., Goss R.J., Carter G.T. (eds.) Natural Products: Discourse, Diversity, and Design. John Wiley & Sons, Inc., Hoboken, NJ, USA. pp. 103 - 124. *Raju R., *Garcia R., *Müller R. (2014) Angiolactone, a new Butyrolactone isolated from the terrestrial myxobacterium, Angiococcus sp. Journal of Antibiotics 67: 725 - 726. *Raju R., Gromyko O., Andriy B., Fedorenko V., *Luzhetskyy A., *Müller R. (2014) Oleamycins A and B: New antibacterial cyclic hexadepsipeptides isolated from a terrestrial Streptomyces sp. Journal of Antibiotics 67: 339 - 343. Reker D., Perna A.M., Rodrigues T., Schneider P., Reutlinger M., Monch B., Koeberle A., Lamers C., Gabler M., *Steinmetz H., *Müller R., Schubert-Zsilavecz M., Werz O., Schneider G. (2014) Revealing the macromolecular targets of complex natural products Nature Chemistry 6: 1072 - 1078. Schempp C.M., Von Schwarzenberg K., Schreiner L., Kubisch R., *Müller R., Wagner E., Vollmar A.M. (2014) V-ATPase inhibition regulates anoikis resistance and metastasis of cancer cells Molecular Cancer Therapeutics 13: 926 - 937. Scherer O., *Steinmetz H., Kaether C., Weinigel C., Barz D., Kleinert H., Menche D., *Müller R., Pergola C., Werz O. (2014) Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum Biochemical pharmacology 91: 490 - 500. Simon Y., Kessler S.M., *Gemperlein K., Bohle R.M., *Müller R., Haybaeck J., Kiemer A.K. (2014) Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis World Journal of Gastroenterology 20: 17839 - 17850.

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Sood S.*, *Steinmetz H., Beims H., *Mohr K.I., *Stadler M., Djukic M., von der Ohe W., Steinert M., Daniel R., *Müller R. (2014) Paenilarvins: Iturin Family Lipopeptides from the Honey Bee Pathogen Paenibacillus larvae ChemBioChem 15: 1947 - 1955. *Surup F., *Viehrig K., *Mohr K.I., *Herrmann J., *Jansen R., *Müller R. (2014) Disciformycins A and B: 12-membered macrolide glycoside antibiotics from the myxobacterium Pyxidicoccus fallax active against multiresistant staphylococci Angewandte Chemie - International Edition 53: 13588 - 13591. von Schwarzenberg K., Lajtos T., Simon L., *Müller R., Vereb G., Vollmar A.M. (2014) V-ATPase inhibition overcomes trastuzumab resistance in breast cancer Molecular Oncology 8: 9 - 19. Wang H., *Bian X., Xia L., Ding X., *Müller R., Zhang Y., Fu J., Stewart A.F. (2014) Improved seamless mutagenesis by recombineering using ccdB for counterselection Nucleic Acids Research 42: e37. *Bian X., Fu J., *Plaza A., *Herrmann J., *Pistorius D., Stewart A.F., Zhang Y., *Müller R. (2013) In Vivo Evidence for a Prodrug Activation Mechanism during Colibactin Maturation ChemBioChem 14: 1194 - 1197. Eichhorn T., Hiller C., *Hirschfelder K., Frank M., Krauth-Siege R.L., *Müller R., Mertens R., Efferth T. (2013) Identification by high-throughput in silico screening of radio-protecting compounds targeting the DNA-binding domain of the tumor suppressor p53 Cancer Genomics and Proteomics 10: 35 - 46. *Herrmann J., *Hüttel S., *Müller R. (2013) Discovery and Biological Activity of New Chondramides from Chondromyces sp. ChemBioChem 14: 1573 - 1580. *Hoffmann T., *Müller S., *Nadmid S., *Garcia R., *Müller R. (2013) Microsclerodermins from terrestrial myxobacteria: An intriguing biosynthesis likely connected to a sponge symbiont Journal of the American Chemical Society 135: 16904 - 16911. *Hüttel S., *Herrmann J., *Müller R. (2013) Research on natural products. Treasures from the soil: Innovative processes in the search for active substances [Naturstoffforschung. Schätze aus dem Boden: Innovative Prozesse zur Wirkstofffindung] BioSpektrum 19: 520 - 522. *Irschik H., *Washausen P., *Sasse F., Fohrer J., Huch V., *Müller R., *Prusov E.V. (2013) Isolation, structure elucidation, and biological activity of maltepolides: Remarkable macrolides from myxobacteria Angewandte Chemie - International Edition 52: 5402 - 5405. Kaufmann K., Simmons L., Herrmann J., Schwar G., Luniak N., *Müller R. (2013) Activity-guided screening of bioactive natural compounds implementing a new glucocorticoid-receptor-translocation assay and detection of new anti-inflammatory steroids from bacteria Biotechnology Letters 35: 11 - 20. Li X.-W., *Herrmann J., Zang Y., Grellier P., Prado S., *Müller R., Nay B. (2013) Synthesis and biological activities of the respirator chain inhibitor aurachin D and new ring versus chain analogues Beilstein Journal of Organic Chemistry 9: 1551 - 1558. *Li Y., *Luxenburger E., *Müller R. (2013) An alternative isovaleryl CoA biosynthetic pathway involving a previously unknown 3-methylglutaconyl CoA decarboxylase Angewandte Chemie - International Edition 4: 1304 - 1308. Ongley S.E., *Bian X., Neilan B.A., *Müller R. (2013) Recent advances in the heterologous expression

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of microbial natural product biosynthetic pathways. Natural Product Reports 30: 1121 - 1138. Ongley S.E., *Bian X., Zhang Y., Chau R., Gerwick W.H., *Müller R., Neilan B.A. (2013) High-titer heterologous production in E. coli of lyngbyatoxin, a protein kinase C activator from an uncultured marine cyanobacterium ACS Chemical Biology 8: 1888 - 1893. *Plaza A., *Viehrig K., *Garcia R., *Müller R. (2013) Jahnellamides, α-Keto-β-Methionine-Containing Peptides from the Terrestrial Myxobacterium Jahnella sp.: Structure and Biosynthesis Organic Letters 15: 5882 - 5885. *Raju R., Gromyko O., Fedorenko V., *Herrmann J., *Luzhetskyy A., *Müller R. (2013) Rubimycinone A, a new anthraquinone from a terrestrial Streptomyces sp. Tetrahedron Letters 54: 900 - 902. *Raju R., Gromyko O., Fedorenko V., *Luzhetskyy A., *Müller R. (2013) Lorneic acids C and D, new trialkyl-substituted aromatic acids isolated from a terrestrial Streptomyces sp. Journal of Antibiotics 66: 347 - 349. Schmalzbauer B., *Herrmann J., *Müller R., Menche D. (2013) Total synthesis and antibacterial activity of dysidavarone A Organic Letters 15: 964 - 967. *Storz M.P., *Brengel C., *Weidel E., *Hoffmann M., Hollemeyer K., *Steinbach A., *Müller R., *Empting M., *Hartmann R.W. (2013) Biochemical and biophysical analysis of a chiral PqsD inhibitor revealing tight-binding behavior and enantiomers with contrary thermodynamic signatures ACS Chemical Biology 8: 2794 - 2801. *Sucipto H., *Wenzel S.C., *Müller R. (2013) Exploring Chemical Diversity of α-Pyrone Antibiotics: Molecular Basis of Myxopyronin Biosynthesis ChemBioChem 14: 1581 - 1589. *Viehrig K., *Surup F., *Harmrolfs K., *Jansen R., *Kunze B., *Müller R. (2013) Concerted action of P450 plus helper protein to form the amino-hydroxy-piperidone moiety of the potent protease inhibitor crocapeptin Journal of the American Chemical Society 135: 16885 - 16894. *Wenzel S.C., *Müller R. (2013) Antibiotika. In: Sahm H., AntranikianG., Stahmann K.P., Takors R. (eds.) Industrielle Mikrobiologie. Springer Spektrum, Berlin/Heidelberg. pp. 149 - 178. Young J., Stevens D.C., Carmichael R., Tan J., *Rachid S., Boddy C.N., *Müller R., Taylor R.E. (2013) Elucidation of gephyronic acid biosynthetic pathway revealed unexpected sam-dependent methylations Journal of Natural Products 76: 2269 - 2276. Zhao Q., Zeino M., Eichhorn T., Herrmann J., *Müller R., Efferth T. (2013) Molecular docking studies of myxobacterial disorazoles and tubulysins to tubulin The Journal of Bioscience and Medicine 3: 37 - 44.

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Stadler, Marc

Ashrafi S., *Helaly S., Schroers H.-J., *Stadler M., Richert-Poeggeler K.R., Dababat A.A., Maier W.

(2017) Ijuhya vitellina sp. nov., a novel source for chaetoglobosin A, is a destructive parasite of the

cereal cyst nematode Heterodera filipjevi PLoS ONE 12: e0180032.

Ashrafi S., *Stadler M., Dababat A.A., Richert-Pöggeler K.R., Finckh M.R., Maier W. (2017)

Monocillium gamsii sp. nov. and Monocillium bulbillosum: Two nematode-associated fungi

parasitising the eggs of Heterodera filipjevi MycoKeys 27: 21 - 38.

Baral H.-O., Weber E., Gams W., Hagedorn G., Liu B., Liu X., Marson G., Marvanová L., *Stadler M.,

Weiß M. (2017) Generic names in the Orbiliaceae (Orbiliomycetes) and recommendations on which

names should be protected or suppressed Mycological Progress doi: 10.1007/s11557-017-1300-6.

*Beckmann A., *Hüttel S., *Schmitt V., *Müller R., *Stadler M. (2017) Optimization of the

biotechnological production of a novel class of anti-MRSA antibiotics from Chitinophaga sancti

Microbial Cell Factories 16: 143.

*Chepkirui C., Matasyoh J.C., Decock C., *Stadler M. (2017) Two cytotoxic triterpenes from cultures

of a Kenyan Laetiporus sp. (Basidiomycota) Phytochemistry Letters 20: 106 - 110.

*Chepkirui C., *Stadler M. (2017) The genus Diaporthe: a rich source of diverse and bioactive

metabolites Mycological Progress 16: 477 - 494.

*Halecker S., *Surup F., Solheim H., *Stadler M. (2017) Albiducins A and B, salicylaldehyde antibiotics

from the ash tree-associated saprotrophic fungus Hymenoscyphus albidus Journal of Antibiotics doi:

10.1038/ja.2017.66.

*Helaly S.E., *Kuephadungphan W., Phongpaichit S., Luangsa-Ard J.J., Rukachaisirikul V., *Stadler M.

(2017) Five unprecedented secondary metabolites from the spider parasitic fungus Akanthomyces

novoguineensis Molecules 22: 991.

*Hüttel S., *Testolin G., *Herrmann J., Planke T., Gille F., Moreno M., *Stadler M., *Brönstrup M.,

Kirschning A., *Müller R. (2017) Discovery and Total Synthesis of Natural Cystobactamid Derivatives

with Superior Activity against Gram-Negative Pathogens Angewandte Chemie - International Edition

56: 12760 - 12764.

Kuephadungphan W., Helaly S.E., Daengrot C., Phongpaichit S., Luangsa-Ard J.J., Rukachaisirikul V.,

Stadler M. (2017) Akanthopyrones A-D, a-Pyrones Bearing a 4-O-Methyl-ß-d-glucopyranose Moiety

from the Spider-Associated Ascomycete Akanthomyces novoguineensis Molecules 22: 1202.

*Kuhnert E., *Surup F., *Halecker S., *Stadler M. (2017) Minutellins A - D, azaphilones from the

stromata of Annulohypoxylon minutellum (Xylariaceae) Phytochemistry 137: 66 - 71.

Landwehr W., Kämpfer P., Glaeser S.P., Rückert C., Kalinowski J., Blom J., Goesmann A., Mack M.,

Schumann P., Atasayar E., Hahnke R.L., *Rohde M., Martin K., *Stadler M., *Wink J. (2017)

Taxonomic analyses of members of the Streptomyces cinnabarinus cluster, description of

Streptomyces cinnabarigriseus sp. nov. and Streptomyces davaonensis sp. nov International Journal

of Systematic and Evolutionary Microbiology 68: 382 - 393.

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Mohammadi-Ostad-Kalayeh S., Hrupins V., Helmsen S., Stahl F., Scheper T., Preller M., *Surup F.,

*Stadler M., Kirschning A., Zeilinger C. (2017) Development of a microarray-based assay for efficient

testing of new HSP70/DnaK inhibitors Bioorganic and Medicinal Chemistry 25: 6345 - 6352.

*Mohr K.I., Zindler T., *Wink J., Wilharm E., *Stadler M. (2017) Myxobacteria in high moor and fen:

An astonishing diversity in a neglected extreme habitat MicrobiologyOpen 6: e00464 - .

*Noumeur S.R., *Helaly S.E., *Jansen R., *Gereke M., *Stradal T.E.B., Harzallah D., *Stadler M. (2017)

Preussilides A-F, Bicyclic Polyketides from the Endophytic Fungus Preussia similis with

Antiproliferative Activity Journal of Natural Products 80: 1531 - 1540.

Rodrigo S., Santamaria O., *Halecker S., Lledó S., *Stadler M. (2017) Antagonism between

Byssochlamys spectabilis (anamorph Paecilomyces variotii) and plant pathogens: Involvement of the

bioactive compounds produced by the endophyte Annals of Applied Biology 171: 464 - 476..

*Surup F., *Kuhnert E., Böhm A., *Wiebach V., Solga D., Engler H., Pendzialek T., Berkessel A.,*Stadler

M., *Kalesse M. (2017) The rickiols, 20-, 22-, and 24-membered macrolides from the ascomycete

Hypoxylon rickii Chemistry doi: 10.1002/chem.201704928.

*Teponno R.B., *Noumeur S.R., *Helaly S.E., *Hüttel S., Harzallah D., *Stadler M. (2017) Furanones

and anthranilic acid derivatives from the endophytic fungus Dendrothyrium variisporum Molecules

22: 1674.

Thongbai B., *Wittstein K., *Richter C., Miller S.L., Hyde K.D., Thongklang N., Klomklung N.,

Chukeatirote E., *Stadler M. (2017) Successful cultivation of a valuable wild strain of Lepista sordida

from Thailand Mycological Progress 16: 311 - 323.

Thongbai B., Miller S.L., *Stadler M., *Wittstein K., Hyde K.D., Lumyong S., Raspé O. (2017) Study of

three interesting Amanita species from Thailand: Morphology, multiple-gene phylogeny and toxin

analysis PLoS ONE 12: e0182131.

*Wendt L., Sir E.B., *Kuhnert E., *Heitkämper S., *Lambert C., Hladki A.I., Romero A.I., Luangsa-ard

J.J., Srikitikulchai P., Peršoh D., *Stadler M. (2017) Resurrection and emendation of the

Hypoxylaceae, recognised from a multigene phylogeny of the Xylariales Mycological Progress doi:

10.1007/s11557-017-1311-3.

Yuyama K.T., Chepkirui C., Wendt L., Fortkamp D., *Stadler M., *Abraham W.R. (2017) Bioactive

Compounds Produced by Hypoxylon fragiforme against Staphylococcus aureus Biofilms

Microorganisms 5: 80.

*Chepkirui C., *Richter C., Matasyoh J.C., *Stadler M. (2016) Monochlorinated calocerins A-D and 9-

oxostrobilurin derivatives from the basidiomycete Favolaschia calocera Phytochemistry 132: 95 -

101.

Daranagama D.A., Camporesi E., Jeewon R., Liu X., *Stadler M., Lumyong S., Hyde K.D. (2016)

Taxonomic Rearrangement of Anthostomella (Xylariaceae) Based on a Multigene Phylogeny and

Morphology Cryptogamie, Mycologie 37: 509 - 538.

227

Daranagama D.A., Camporesi E., Liu X.Z., Bhat D.J., Chamyuang S., Bahkali A.H., *Stadler M., Hyde

K.D. (2016) Tristratiperidium microsporum gen. et sp. nov. (Xylariales) on dead leaves of Arundo plinii

Mycological Progress 15: 1 - 8.

Daranagama D.A., Jones E.B.G., Liu X.Z., To-Anun C., *Stadler M., Hyde K.D. (2016) Mycosphere

essays 13 - Do xylariaceous macromycetes make up most of the Xylariomycetidae? Mycosphere 7:

582 - 601.

Daranagama D.A., Liu X., Chamyuang S., *Stadler M., Bahkali A.H., Hyde K.D. (2016) Towards a

natural classification of Sordariomycetes: The genera Frondisphaeria, Immersisphaeria, Lasiobertia,

Pulmosphaeria and Yuea (Sordariomycetes incertae sedis) Phytotaxa 258: 153 - 163.

Dayarathne M.C., Boonmee S., Braun U., Crous P.W., Daranagama D.A., Dissanayake A.J., Ekanayaka

H., Jayawardena R., Jones E.B.G., Maharachchikumbura S.S.N., Perera R.H., Phillips A.J.L., *Stadler M.,

Thambugala K.M., Wanasinghe D.N., Zhao Q., Hyde K.D., J (2016) Taxonomic utility of old names in

current fungal classification and nomenclature: Conflicts, confusion & clarifications Mycosphere 7:

1622 - 1648.

*Garcia R., *Stadler M., *Gemperlein K., *Müller R. (2016) Aetherobacter fasciculatus gen. nov., sp.

nov. and Aetherobacter rufus sp. nov., novel myxobacteria with promising biotechnological

applications International Journal of Systematic and Evolutionary Microbiology 66: 928 - 938.

*Helaly S.E., *Richter C., Thongbai B., Hyde K.D., *Stadler M. (2016) Lentinulactam, a hirsutane

sesquiterpene with an unprecedented lactam modification Tetrahedron Letters 57: 5911 - 5913.

Hyde K.D., Hongsanan S., Jeewon R., Bhat D.J., McKenzie E.H.C., Jones E.B.G., Phookamsak R.,

Ariyawansa H.A., Boonmee S., Zhao Q., Abdel-Aziz F. A., Abdel-Wahab M.A., Banmai S., Chomnunti P.,

Cui B.-K., Daranagama D.A., Das K., Dayarathne M.C., de Silva N.I., Dissanayake A.J., Doilom M.,

Ekanayaka A.H., Gibertoni T.B., Góes-Neto A., Huang S.-K., Jayasiri S.C., Jayawardena R.S., Konta S.,

Lee H.B., Li W.-J., Lin C.-G., Liu J.-K., Lu Y.-Z., Luo Z.-L., Manawasinghe I.S., Manimohan P., Mapook A.,

Niskanen T., Norphanphoun C., Papizadeh M., Perera R.H., Phukhamsakda C., *Richter C., de A.

Santiago A.L.C.M., Drechsler-Santos E.R., Senanayake I.C., Tanaka K., Tennakoon T.M.D.S.,

Thambugala K.M., Tian Q., Tibpromma S., Thongbai B., Vizzini A., Wanasinghe D.N., Wijayawardene

N.N., Wu H.-X., Yang J., Zeng X.-Y., Zhang H., Zhang J.-F., Bulgakov T.S., Camporesi E., Bahkali A.H.,

Amoozegar M.A., Araujo-Neta L.S., Ammirati J.F., Baghela A., Bhatt R.P., Bojantchev D., Buyck B., da

Silva G.A., Ferreira de Lima C. L., Vilela de Oliveira R.J., Fragoso de Souza C.A., Dai Y.-C., Dima B.,

Duong T.T., Ercole E., Mafalda-Freire F., Ghosh A., Hashimoto A., Kamolhan S., Kang J.-C.,

Karunarathna S.C., Kirk P.M., Kytövuori I., Lantieri A., Liimatainen K., Liu Z.-Y., Liu X-Z., Lücking R.,

Medardi G., Mortimer P.E., Nguyen T.T.T., Promputtha I., Raj K.N.A., Reck M.A., Lumyong S.,

Shahzadeh-Fazeli S.A., *Stadler M., Soudi M.R., Su H.-Y., Takahashi T., Tangthirasunun N., Uniyal P.,

Wang Y., Wen T.-C., Xu J.-C., Zhang Z.-K., Zhao Y.-C., Zhou J.-L., Zhu L. (2016) Fungal diversity notes

367-490: taxonomic and phylogenetic contributions to fungal taxa Fungal Diversity 80: 1 - 270.

*Karwehl S., *Jansen R., Huch V., *Stadler M. (2016) Sorazolons, Carbazole Alkaloids from Sorangium

cellulosum Strain Soce375 Journal of Natural Products 79: 369 - 375.

*Karwehl S., *Stadler M. (2016) Exploitation of fungal biodiversity for discovery of novel antibiotics

228


Li G.J., Hyde K.D., Zhao R.L., Hongsanan S., Abdel-Aziz F.A., Abdel-Wahab M.A., Alvarado P., Alves-

Silva G., Ammirati J.F., Ariyawansa H.A., Baghela A., Bahkali A.H., Beug M., Bhat D.J., Bojantchev D.,

Boonpratuang T., Bulgakov T.S., Camporesi E., Boro M.C., Ceska O., Chakraborty D., Chen J.J.,

Chethana K.W.T., Chomnunti P., Consiglio G., Cui B.K., Dai D.Q., Dai Y.C., Daranagama D.A., Das K.,

Dayarathne M.C., De Crop E., De Oliveira R.J.V., Fragoso de Souza C.A., de Souza J.I., Dentinger

B.T.M., Dissanayake A.J., Doilom M., Drechsler-Santos E.R., Ghobad-Nejhad M., Gilmore S.P., Góes-

Neto A., Gorczak M., Haitjema C.H., Hapuarachchi K.K., Hashimoto A., He M.Q., Henske J.K., Hirayama

K., Iribarren M.J., Jayasiri S.C., Jayawardena R.S., Jeon S.J., Jerônimo G.H., Jesus A.L., Jones E.B.G.,

Kang J.C., Karunarathna S.C., Kirk P.M., Konta S., *Kuhnert E., Langer E., Lee H.S., Lee H.B., Li W.J., Li

X.H., Liimatainen K., Lima D.X., Lin C.G., Liu J.K., Liu X.Z., Liu Z.Y., Luangsa-ard J.J., Lücking R., Lumbsch

H.T., Lumyong S., Leaño E.M., Marano A.V., Matsumura M., McKenzie E.H.C., Mongkolsamrit S.,

Mortimer P.E., Nguyen T.T.T., Niskanen T., Norphanphoun C., O’Malley M.A., Parnmen S., Pawłowska

J., Perera R.H., Phookamsak R., Phukhamsakda C., Pires-Zottarelli C.L.A., Raspé O., Reck M.A., Rocha

S.C.O., de Santiago A.L.C.M.A., Senanayake I.C., Setti L., Shang Q.J., Singh S.K., Sir E.B., Solomon K.V.,

Song J., Srikitikulchai P., *Stadler M., Suetrong S., Takahashi H., Takahashi T., Tanaka K., Tang L.P.,

Thambugala K.M., Thanakitpipattana D., Theodorou M.K., Thongbai B., Thummarukcharoen T., Tian

Q., Tibpromma S., Verbeken A., Vizzini A., Vlasák J., Voigt K., Wanasinghe D.N., Wang Y., Weerakoon

G., Wen H.A., Wen T.C., Wijayawardene N.N., Wongkanoun S., Wrzosek M., Xiao Y.P., Xu J.C., Yan J.Y.,

Yang J., YangS.D. , Hu Y., Zhang J.F., Zhao J., Zhou L.W., Peršoh D., Phillips A.J.L.,

Maharachchikumbura S.S.N. (2016) Fungal diversity notes 253-366: taxonomic and phylogenetic

contributions to fungal taxa Fungal Diversity 78: 1 - 237.

Maharachchikumbura S.S.N., Hyde K.D., Jones E.B.G., McKenzie E.H.C., Bhat J.D., Dayarathne M.C.,

Huang S.-K., Norphanphoun C., Senanayake I.C., Perera R.H., Shang Q.-J., Xiao Y., D’souza M.J.,

Hongsanan S., Jayawardena R.S., Daranagama D.A., Konta S., Goonasekara I.D., Zhuang W.-Y., Jeewon

R., Phillips A.J.L., Abdel-Wahab M.A., Al-Sadi A.M., Bahkali A.H., Boonmee S., Boonyuen N.,

Cheewangkoon R., Dissanayake A.J., Kang J., Li Q.R., Liu J.K., Liu X.Z., Liu Z.-Y. , Luangsa-ard J.J., Pang

K.-L., Phookamsak R., Promputtha I., Suetrong S., *Stadler M., Wen T., Wijayawardene N.N. (2016)

Families of Sordariomycetes Fungal Diversity 79: 1 - 317.

*Mohr K.I., *Stechling M., *Wink J., Wilharm E., *Stadler M. (2016) Comparison of myxobacterial

diversity and evaluation of isolation success in two niches: Kiritimati Island and German compost

MicrobiologyOpen 5: 268 - 278.

Mudalungu C.M., *Richter C., *Wittstein K., Abdalla M.A., Matasyoh J.C., *Stadler M., Süssmuth R.D.

(2016) Laxitextines A and B, Cyathane Xylosides from the Tropical Fungus Laxitextum incrustatum

Journal of Natural Products 79: 894 - 898.

Otto A., Laub A., *Wendt L., Porzel A., Schmidt J., Palfner G., Becerra J., Krüger D., *Stadler M.,

Wessjohann L., Westermann B., Arnold N. (2016) Chilenopeptins A and B, Peptaibols from the

Chilean Sepedonium aff. chalcipori KSH 883 Journal of Natural Products 79: 929 - 938.

*Richter C., *Helaly S.E., Thongbai B., Hyde K.D., *Stadler M. (2016) Pyristriatins A and B: Pyridino-

Cyathane Antibiotics from the Basidiomycete Cyathus cf. striatus Journal of Natural Products 79:

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229

Samarakoon M.C., Hyde K.D., Promputtha I., Hongsanan S., Ariyawansa H., Maharachchikumbura

S.S.N., Daranagama .D.A., *Stadler M., Mapook A. (2016) Evolution of Xylariomycetidae (Ascomycota:

Sordariomycetes) Mycosphere 7: 1746 - 1761.

Sir E.B., *Kuhnert E., *Lambert C., Hladki A.I., Romero A.I., *Stadler M. (2016) New species and

reports of Hypoxylon from Argentina recognized by a polyphasic approach Mycological Progress 15:

42.

Sir E.B., *Lambert C., *Wendt L., Hladki A.I., Romero A.I., *Stadler M. (2016) A new species of

Daldinia (Xylariaceae) from the Argentine subtropical montane forest Mycosphere 7: 1378 - 1388.

*Sudarman E., *Kuhnert E., Hyde K.D., Sir E.B., *Surup F., *Stadler M. (2016) Truncatones A-D,

benzo[j]fluoranthenes from Annulohypoxylon species (Xylariaceae, Ascomycota) Tetrahedron 72:

6450 - 6454.

*Surup F., *Wiebach V., *Kuhnert E., *Stadler M. (2016) Truncaquinones A and B, asterriquinones

from Annulohypoxylon truncatum Tetrahedron Letters 57: 2183 - 2185.

*Wiebach V., *Surup F., *Kuhnert E., *Stadler M. (2016) Rickicaryophyllane A, a Caryophyllane from

the Ascomyceteous Fungus Hypoxylon rickii and a 10-Norbotryane Congener Natural Product

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*Wittstein K., Rascher M., *Rupcic Z., *Löwen E., Winter B., Köster R.W., *Stadler M. (2016)

Corallocins A-C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the

Mushroom Hericium coralloides Journal of Natural Products 79: 2264 - 2269.

Ariyawansa H.A., Hyde K.D., Jayasiri S.C., Buyck B., Chethana K.W.T., Dai D.Q., Dai Y.C., Daranagama

D.A., Jayawardena R.S., Lücking R., Ghobad-Nejhad M., Niskanen T., Thambugala K.M., Voigt K., Zhao

R.L., Li G.-J., Doilom M., Boonmee S., Yang Z.L., Cai Q., Cui Y.-Y., Bahkali A.H., Chen J., Cui B.K., Chen

J.J., Dayarathne M.C., Dissanayake A.J., Ekanayaka A.H., Hashimoto A., Hongsanan S., Jones E.B.G.,

Larsson E., Li W.J., Li Q.-R., Liu J.K., Luo Z.L., Maharachchikumbura S.S.N., Mapook A., McKenzie

E.H.C., Norphanphoun C., Konta S., Pang K.L., Perera R.H., Phookamsak R., Phukhamsakda C., Pinruan

U., Randrianjohany E., Singtripop C., Tanaka K., Tian C.M., Tibpromma S., Abdel-Wahab M.A.,

Wanasinghe D.N., Wijayawardene N.N., Zhang J.-F., Zhang H., Abdel-Aziz F.A., Wedin M., Westberg

M., Ammirati J.F., Bulgakov T.S., Lima D.X., Callaghan T.M., Callac P., Chang C.-H., Coca L.F., Dal-Forno

M., Dollhofer V., Fliegerová K., Greiner K., Griffith G.W., Ho H.-M., Hofstetter V., Jeewon R., Kang J.C.,

Wen T.-C., Kirk P.M., Kytövuori I., Lawrey J.D., Xing J., Li H., Liu Z.Y., Liu X.Z., Liimatainen K., Lumbsch

H.T., Matsumura M., Moncada B., Nuankaew S., Parnmen S., de Azevedo Santiago A.L.C.M., Sommai

S., Song Y., de Souza C.A.F., de Souza-Motta C.M., Su H.Y., Suetrong S., Wang Y., Wei S.-F., Wen T.C.,

Yuan H.S., Zhou L.W., Réblová M., Fournier J., Camporesi E., Luangsa-ard J.J., Tasanathai K., Khonsanit

A., Thanakitpipattana D., Somrithipol S., Diederich P., Millanes A.M., Common R.S., *Stadler M., Yan

J.Y., Li XH., Lee H.W., Nguyen T.T.T., Lee H.B., Battistin E., Marsico O., Vizzini A., Vila J., Ercole E.,

Eberhardt U., Simonini G., Wen H.-A., Chen X.-H., Miettinen O., Spirin V., Hernawati. (2015) Fungal

diversity notes 111–252—taxonomic and phylogenetic contributions to fungal taxa Fungal Diversity

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*Bruns N., *Collisi W., *Bernecker S., *Stadler M., Richter C., Schwalbe H., *Kalesse M. (2015)

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elucidation, and biological activity European Journal of Organic Chemistry 2015: 847 - 857.

Daranagama D.A., Camporesi E., Tian Q., Liu X., Chamyuang S., *Stadler M., Hyde K.D. (2015)

Anthostomella is polyphyletic comprising several genera in Xylariaceae Fungal Diversity 73: 203 -

238.

Daranagama D.A., Liu X., Chamyuang S., *Stadler M., Bahkali A.H., Hyde K.D. (2015) Rhopalostroma

brevistipitatum sp. nov. From Thailand with an extended generic description for Rhopalostroma

Phytotaxa 227: 229 - 242.

*Karwehl S., *Mohr K.I., *Jansen R., *Sood S., *Bernecker S., *Stadler M. (2015) Edonamides, the first

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Tetrahedron Letters 56: 6402 - 6404.

*Kuhnert E., *Surup F., *Herrmann J., Huch V., *Müller R., *Stadler M. (2015) Rickenyls A-E,

antioxidative terphenyls from the fungus Hypoxylon rickii (Xylariaceae, Ascomycota) Phytochemistry

118: 68 - 73.

*Kuhnert E., *Surup F., *Wiebach V., *Bernecker S., *Stadler M. (2015) Botryane, noreudesmane and

abietane terpenoids from the ascomycete Hypoxylon rickii Phytochemistry 117: 116 - 122.

*Kuhnert E., *Surup F., Sir E.B., *Lambert C., Hyde K.D., Hladki A.I., Romero A.I., *Stadler M. (2015)

Lenormandins A—G, new azaphilones from Hypoxylon lenormandii and Hypoxylon jaklitschii sp. nov.,

recognised by chemotaxonomic data Fungal Diversity 71: 165 - 184.

*Mohr K.I., *Volz C., *Jansen R., *Wray V., *Hoffmann J., *Bernecker S., *Wink J., *Gerth K., *Stadler

M., *Müller R. (2015) Pinensins: The First Antifungal Lantibiotics Angewandte Chemie - International

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*Richter C., *Wittstein K., Kirk P.M., *Stadler M. (2015) An assessment of the taxonomy and

chemotaxonomy of Ganoderma Fungal Diversity 71: 1 .

Senanayake I.C., Maharachchikumbura S.S.N., Hyde K.D., Bhat J.D., Jones E.B.G., McKenzie E.H.C., Dai

D.Q., Daranagama D.A., Dayarathne M.C., Goonasekara I.D., Konta S., Li W.J., Shang Q.J., *Stadler M.,

Wijayawardene N.N., Xiao Y.P., Norphanphoun C., Li Q (2015) Towards unraveling relationships in

Xylariomycetidae (Sordariomycetes) Fungal Diversity 73: 73 - 144.

Sir E.B., *Kuhnert E., *Surup F., Hyde K.D., *Stadler M. (2015) Discovery of new mitorubrin

derivatives from Hypoxylon fulvo-sulphureum sp. nov. (Ascomycota, Xylariales) Mycological Progress

14: 15p.


Schumann P., *Garcia R., *Müller R. (2015) Aggregicoccus edonensis gen. nov., sp. nov., an unusually



*Stadler M., Hoffmeister D. (2015) Fungal natural products-the mushroom perspective Frontiers in


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*Surup F., *Kuhnert E., *Liscinskij E., *Stadler M. (2015) Silphiperfolene-Type Terpenoids and Other

Metabolites from Cultures of the Tropical Ascomycete Hypoxylon rickii (Xylariaceae) Natural

Products and Bioprospecting 5: 167 - 173.

*Surup F., Medjedovic A., Schroers H.-J., *Stadler M. (2015) Production of Obionin A and Derivatives

by the Sooty Blotch Fungus Microcyclospora malicola Planta Medica 81: 1339 - 1344.

*Surup F., Thongbai B., *Kuhnert E., *Sudarman E., Hyde K.D., *Stadler M. (2015) Deconins A-E:

Cuparenic and mevalonic or propionic acid conjugates from the basidiomycete Deconica sp. 471

Journal of Natural Products 78: 934 - 938.

*Thongbai B., Rapior S., Hyde K.D., *Wittstein K., *Stadler M. (2015) Hericium erinaceus, an amazing

medicinal mushroom Mycological Progress 14: 91.

Wang L., Feng Y., Tian J., Xiang M., Sun J., Ding J., Yin W.B., *Stadler M., Che Y., Liu X. (2015) Farming

of a defensive fungal mutualist by an attelabid weevil ISME Journal 9: 1793 - 1801.

Wang X., Zhang X., Liu L., Xiang M., Wang W., Sun X., Che Y., Guo L., Liu G., Guo L., Wang C., Yin W.-

B., *Stadler M., Zhang X., Liu X. (2015) Genomic and transcriptomic analysis of the endophytic fungus

reveals its lifestyle and high potential for synthesis of natural products BMC Genomics 16: 1190.

*Baumann S., *Herrmann J., *Raju R., *Steinmetz H., *Mohr K.I., *Hüttel S., *Harmrolfs K., *Stadler

M., *Müller R. (2014) Cystobactamids: Myxobacterial topoisomerase inhibitors exhibiting potent

antibacterial activity Angewandte Chemie - International Edition 53: 14605 - 14609.

Chomnunti P., Hongsanan S., Aguirre-Hudson B., Tian Q., Persoh D., Dhami M.K., Alias A.S., Xu J., Liu

X., *Stadler M., Hyde K.D. (2014) The sooty moulds Fungal Diversity 66: 1 - 36.

Daranagama D.A., Liu X., Chamyuang S., *Stadler M., Hyde K.D. (2014) A multiple gene genealogy

reveals phylogenetic placement of Rhopalostroma lekae Phytotaxa 186: 177 - 187.

*Halecker S., *Surup F., *Kuhnert E., *Mohr K.I., Brock N.L., Dickschat J.S., Junker C., Schulz B.,

*Stadler M. (2014) Hymenosetin, a 3-decalinoyltetramic acid antibiotic from cultures of the ash

dieback pathogen, Hymenoscyphus pseudoalbidus Phytochemistry 100: 86 - 91.

*Jansen R., *Mohr K.I., *Bernecker S., *Stadler M., *Müller R. (2014) Indothiazinone, an indolyl

thiazolyl ketone from a novel myxobacterium belonging to the sorangiineae Journal of Natural

Products 77: 1054 - 1060.

*Jansen R., *Sood S., *Mohr K.I., *Kunze B., *Irschik H., *Stadler M., *Müller R. (2014) Nannozinones

and sorazinones, unprecedented pyrazinones from myxobacteria Journal of Natural Products 77:

2545 - 2552.

*Jansen R., *Sood S., Huch V., *Kunze B., *Stadler M., *Müller R. (2014) Pyrronazols, metabolites

from the myxobacteria Nannocystis pusilla and N. exedens, are unusual chlorinated pyrone-oxazole-

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*Kuhnert E., *Heitkamper S., Fournier J., *Surup F., *Stadler M. (2014) Hypoxyvermelhotins A-C, new

pigments from Hypoxylon lechatii sp. nov Fungal Biology 118: 242 - 252.

*Kuhnert E., Fournier J., Persoh D., Luangsa-Ard J.J.D., *Stadler M. (2014) New Hypoxylon species

from Martinique and new evidence on the molecular phylogeny of Hypoxylon based on ITS rDNA and

β-tubulin data Fungal Diversity 64: 181 - 203.

*Okanya P.W., *Mohr K.I., *Gerth K., *Kessler W., *Jansen R., *Stadler M., *Müller R. (2014)

Hyafurones, hyapyrrolines, and hyapyrones: Polyketides from Hyalangium minutum Journal of

Natural Products 77: 1420 - 1429.

Shen T., Hof L.M., Hausmann H., *Stadler M., Zorn H. (2014) Development of an enzyme linked

immunosorbent assay for detection of cyathane diterpenoids BMC Biotechnology 14: 98.

Sood S.*, *Steinmetz H., Beims H., *Mohr K.I., *Stadler M., Djukic M., von der Ohe W., Steinert M.,

Daniel R., *Müller R. (2014) Paenilarvins: Iturin Family Lipopeptides from the Honey Bee Pathogen

Paenibacillus larvae ChemBioChem 15: 1947 - 1955.

*Stadler M., Hawksworth D.L., Fournier J. (2014) The application of the name Xylaria hypoxylon,

based on Clavaria hypoxylon of Linnaeus IMA Fungus 5: 57 - 66.

*Stadler M., Læssøe T., Fournier J., Decock C., Schmieschek B., Tichy H.V., Peršoh D. (2014) A

polyphasic taxonomy of Daldinia (Xylariaceae) Studies in Mycology 77: 1 - 143.

*Surup F., *Kuhnert E., *Lehmann E., *Heitkamper S., Hyde K.D., Fournier J., *Stadler M. (2014)

Sporothriolide derivatives as chemotaxonomic markers for Hypoxylon monticulosum Mycology 5:

110 - 119.

*Surup F., Medjedovic A., *Szczygielski M., Schroers H.-J., *Stadler M. (2014) Production of

trichothecenes by the apple sooty blotch fungus Microcyclospora tardicrescens Journal of

Agricultural and Food Chemistry 62: 3525 - 3530.

De Silva D.D., Rapior S., *Sudarman E., *Stadler M., Xu J., Aisyah Alias S., Hyde K.D. (2013) Bioactive

metabolites from macrofungi: Ethnopharmacology, biological activities and chemistry Fungal

Diversity 62: 1 - 40.

Kirk P.M., Stalpers J.A., Braun U., Crous P.W., Hansen K., Hawksworth D.L., Hyde K.D., Lücking R.,

Lumbsch T.H., Rossman A.Y., Seifert K.A., *Stadler M. (2013) A without-prejudice list of generic

names of fungi for protection under the International Code of Nomenclature for algae, fungi, and

plants Progress in Biomaterials 4: 381-443.

Læssøe T., Srikitikulchai P., D Luangsa-Ard J.J., *Stadler M. (2013) Theissenia reconsidered, including

molecular phylogeny of the type species T. pyrenocrata and a new genus Durotheca (Xylariaceae,

Ascomycota). IMA Fungus 4: 57 - 69.

Pazoutova S., *Follert S., Bitzer J., *Keck M., *Surup F., Srutka P., Holusa J., *Stadler M. (2013) A new

endophytic insect-associated Daldinia species, recognised from a comparison of secondary

metabolite profiles and molecular phylogeny Fungal Diversity 60: 107 - 123.

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Rambold G., *Stadler M., Begerow D. (2013) Mycology should be recognized as a field in biology at

eye level with other major disciplines - a memorandum Mycological Progress 12: 455 - 463.

*Stadler M., Hyde K.D. (2013) Editorial comment - Volume 60 of Fungal diversity: Special issue

dedicated to the COST Action FA1103, "endophytes in Biotechnology and Agriculture" Fungal

Diversity 60: 1 - 4.

*Stadler M., *Kuhnert E., Persoh D., Fournier J. (2013) The Xylariaceae as model example for a

unified nomenclature following the "One Fungus-One Name" (1F1N) concept Mycology 4: 5 - 21.

*Surup F., *Mohr K.I., *Jansen R., *Stadler M. (2013) Cohaerins G-K, azaphilone pigments from

Annulohypoxylon cohaerens and absolute stereochemistry of cohaerins C-K Phytochemistry 95: 252 -

258.

Thongbai B., *Surup F., *Mohr K., *Kuhnert E., Hyde K.D., *Stadler M. (2013) Gymnopalynes A and B,

chloropropynyl-isocoumarin antibiotics from cultures of the basidiomycete Gymnopus sp. Journal of

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*Beshr G., *Sikandar A., Jemiller E.-M., Klymiuk N., *Hauck D., *Wagner S., Wolf E., *Koehnke J., *Titz

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terminating glycoconjugates Journal of Biological Chemistry 292: 19935 - 19951.

*Calvert M., Mayer C., *Titz A. (2017) An Efficient synthesis of 1,6-anhydro-N-acetymuramic acid

from N-acetyl glucosamine Beilstein Journal of Organic Chemistry 13: 2631 - 2636.

Hu Y., *Beshr G., Garvey C.J., Tabor R.F., *Titz A., Wilkinson B.L. (2017) Photoswitchable Janus

glycodendrimer micelles as multivalent inhibitors of LecA and LecB from Pseudomonas aeruginosa

Colloids and Surfaces B: Biointerfaces 159: 605 - 612.

*Sommer R., *Hauck D., *Titz A. (2017) Efficient two step β-glycoside synthesis from N-acetyl D-

glucosamine: scope and limitations of copper(II) triflate-catalyzed glycosylation ChemistrySelect 2:

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*Sommer R., Makshakova O.N., Wohlschlager T., Hutin S., Marsh M., *Titz A., Künzler M., Varrot A.

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methylated glycans and a unique tetrameric assembly with unprecedented multivalency Structure

Article in Press.





Torge A., *Wagner S., Chaves P.S., Oliveira E.G., Guterres S.S., Pohlmann A.R., *Titz A., Schneider M.,

Beck R.C.R. (2017) Ciprofloxacin-loaded lipid-core nanocapsules as mucus penetrating drug delivery

system intended for the treatment of bacterial infections in cystic fibrosis International Journal of

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*Wagner S., *Hauck D., *Hoffmann M., *Sommer R., *Joachim I., *Müller R., Imberty A., Varrot A.,

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*Beshr G., *Sommer R., *Hauck D., *Siebert D.C.B., Hofmann A., Imberty A., *Titz A. (2016)

Development of a competitive binding assay for the Burkholderia cenocepacia lectin BC2L-A and

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*Joachim I., Rikker S., *Hauck D., Ponader D., Boden S., Sommer R., Hartmann L., *Titz A. (2016)

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*Sommer R., *Hauck D., Varrot A., Imberty A., Künzler M., *Titz A. (2016) O-Alkylated heavy atom

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methyl-L-selenofucopyranoside Beilstein Journal of Organic Chemistry 12: 2828 - 2833.

*Sommer R., *Wagner S., Varrot A., Nycholat C.M., *Khaledi A., *Häussler S., Paulson J.C., Imberty A.,

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and drug discovery Chemical Science 7: 4990 - 5001.

*Wagner S., *Sommer R., *Hinsberger S., *Lu C., *Hartmann R.W., *Empting M., *Titz A. (2016) Novel

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mannoheptose derivatives and their evaluation as inhibitors of the lectin LecB from the opportunistic

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Rodrigues J.A., Acosta-Serrano A., Aebi M., Ferguson M.A., Routier F.H., Schiller I., Soares S., Spencer

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from Pseudomonas aeruginosa ChemistryOpen 4: 756-767.

Yan S., Brecker L., Jin C., *Titz A., Dragosits M., Karlsson N.G., Jantsch V., Wilson I.B.H., Paschinger K.

(2015) Bisecting galactose as a feature of n-glycans of wild-type and mutant Caenorhabditis elegans

Molecular and Cellular Proteomics 14: 2111 - 2125.

Mosca S., Keller J., Azzouz N., *Wagner S., *Titz A., Seeberger P.H., Brezesinski G., Hartmann L. (2014)

Amphiphilic cationic β3R3-peptides: Membrane active peptidomimetics and their potential as

antimicrobial agents Biomacromolecules 15: 1687 - 1695.

*Sommer R., Exner T.E., *Titz A. (2014) A biophysical study with carbohydrate derivatives explains

the molecular basis of monosaccharide selectivity of the Pseudomonas aeruginosa lectin lecB PLoS

ONE 9: e112822.

*Titz A. (2014) Carbohydrate-based anti-virulence compounds against chronic Pseudomonas

aeruginosa infections with a focus on small molecules Topics in Medicinal Chemistry 12: 169 - 186.

Wohlschlager T., Butschi A., Grassi P., Sutov G., Gauss R., *Hauck D., Schmieder S.S., Knobel M., *Titz

A., Dell A., Haslam S.M., Hengartner M.O., Aebi M., Kunzler M. (2014) Methylated glycans as

conserved targets of animal and fungal innate defense Proceedings of the National Academy of

Sciences of the United States of America 111: E2787 - E2796.


Hauck D., Joachim I., Frommeyer B., Varrot A., Philipp B., Möller H.M., Imberty A., Exner T.E., Titz A.

(2013) Discovery of two classes of potent glycomimetic inhibitors of Pseudomonas aeruginosa LecB

236

with distinct binding modes ACS Chemical Biology 8: 1775 - 1784.

Sommer R., Joachim I., Wagner S., Titz A. (2013) New Approaches to Control Infections: Anti-Biofilm

Strategies against Gram-Negative Bacteria Chimia 67: 286 - 290.

237

Wink, Joachim M.

*Mohr K.I., Moradi A., Glaeser S.P., Kämpfer P., *Gemperlein K., Nübel U., Schumann P., *Müller R.,

*Wink J. (2018) Nannocystis konarekensis sp. nov., a novel myxobacterium from an Iranian desert

International Journal of Systematic and Evolutionary Microbiology doi: 10.1099/ijsem.0.002569.

Charousová I., *Steinmetz H., Medo J., Javoreková S., *Wink J. (2017) Soil myxobacteria as a potential

source of polyketide-peptide substances Folia Microbiologica 62: 305 - 315.

Hamedi J., Poorinmohammad N.,*Wink J. (2017) The Role of Actinobacteria in Biotechnology In:

*Wink J., Mohammadipanah F., Hamedi J. (eds.) Biology and Biotechnology of Actinobacteria.

Springer. pp. 269 - 328.

Kämpfer P., Rückert C., Blom J., Goesmann A., *Wink J., Kalinowski J., Glaeser S.P. (2017)

Streptomyces phaeopurpureus Shinobu 1957 (Approved lists 1980) and Streptomyces

griseorubiginosus (Ryabova and Preobrazhenskaya 1957) Pridham et al. 1958 (approved lists 1980)

are heterotypic subjective synonyms International Journal of Systematic and Evolutionary


Landwehr W., Kämpfer P., Glaeser S.P., Rückert C., Kalinowski J., Blom J., Goesmann A., Mack M.,

Schumann P., Atasayar E., Hahnke R.L., *Rohde M., Martin K., *Stadler M., *Wink J. (2017)

Taxonomic analyses of members of the Streptomyces cinnabarinus cluster, description of

Streptomyces cinnabarigriseus sp. nov. and Streptomyces davaonensis sp. nov International Journal

of Systematic and Evolutionary Microbiology 68: 382 - 393.

*Mohr K.I., Zindler T., *Wink J., Wilharm E., *Stadler M. (2017) Myxobacteria in high moor and fen:

An astonishing diversity in a neglected extreme habitat MicrobiologyOpen 6: e00464.

Moradi A., Ebrahimipour G.H., *Mohr K.I., Kämpfer P., Glaeser S.P., *Hennessen F., *Gemperlein K.,

*Awal R.P., *Wolf C., *Müller R., *Wink J. (2017) Racemicystis persica sp. nov., a myxobacterium

from soil International Journal of Systematic and Evolutionary Microbiology 67: 472 - 478.

*Tokovenko B., Rückert C., Kalinowski J., Mohammadipanah F., *Wink J., Rosenkränzer B.,

Myronovskyi M., *Luzhetskyy A. (2017) Complete draft genome sequence of the actinobacterium

Nocardiopsis sinuspersici UTMC102 (DSM 45277T), which produces serine protease Genome


*Wink J., Mohammadipanah F. (2017) Practical Aspects in Working with Actinobacteria In: *Wink J.,

Mohammadipanah F., Hamedi J. (eds.) Biology and Biotechnology of Actinobacteria. Springer. pp.

329 - 376.

*Wink J., Schumann P., Atasayar E., Klenk H.-P., *Zaburannyi N., Westermann M., Martin K., Glaeser

S.P., Kämpfer P. (2017) Streptomyces caelicus, an antibiotic-producing species of the genus

Streptomyces, and Streptomyces canchipurensis Li et al. 2015 are later heterotypic synonyms of

Streptomyces muensis Ningthoujam et al. 2014 International Journal of Systematic and Evolutionary


Jeske O., *Surup F., Ketteniß M., Rast P., *Förster B., Jogler M., *Wink J., Jogler C. (2016) Developing

techniques for the utilization of planctomycetes as producers of bioactive molecules Frontiers in

238


*Landwehr W., *Wolf C., *Wink J. (2016) Actinobacteria and myxobacteria-two of the most

important bacterial resources for novel antibiotics Current Topics in Microbiology and Immunology

398: 273 - 302.

Mohammadipanah F., *Wink J. (2016) Actinobacteria from arid and desert habitats: Diversity and

biological activity Frontiers in Microbiology 6: 1541.

*Mohr K.I., *Stechling M., *Wink J., Wilharm E., *Stadler M. (2016) Comparison of myxobacterial

diversity and evaluation of isolation success in two niches: Kiritimati Island and German compost

MicrobiologyOpen 5: 268 - 278.

Charousova I., Javorekova S., *Wink J. (2015) Isolation and characterization of Streptomyces

rishiriensis (VY31) with antibiotic activity against various pathogenic microorganisms Journal of

Microbiology, Biotechnology and Food Science 4: 23 - 27.

Citron C.A., Barra L., *Wink J., Dickschat J.S. (2015) Volatiles from nineteen recently genome

sequenced actinomycetes Organic and Biomolecular Chemistry 13: 2673 - 2683.

*Fu C., *Keller L., Bauer A., *Brönstrup M., Froidbise A., Hammann P., *Herrmann J., Mondesert G.,

Kurz M., Schiell M., Schummer D., Toti L., *Wink J., *Müller R. (2015) Biosynthetic Studies of

Telomycin Reveal New Lipopeptides with Enhanced Activity Journal of the American Chemical

Society 137: 7692 - 7705.

*Mohr K., *Wink J. (2015) Von der Bodenprobe zum neuen Naturstoff GIT Labor-Fachzeitschrift 11:

16 - 19.

*Mohr K.I., *Volz C., *Jansen R., *Wray V., *Hoffmann J., *Bernecker S., *Wink J., *Gerth K., *Stadler

M., *Müller R. (2015) Pinensins: The First Antifungal Lantibiotics Angewandte Chemie - International

Edition 54: 11254 - 11258.


Schumann P., *Garcia R., *Müller R. (2015) Aggregicoccus edonensis gen. nov., sp. nov., an unusually



*Müller R., *Wink J. (2014) Future potential for anti-infectives from bacteria - How to exploit

biodiversity and genomic potential International Journal of Medical Microbiology 304: 3 - 13.

*Wink J., Schumann P., Spoer C., Eisenbarth K., Glaeser S.P., Martin K., Kampfer P. (2014) Emended

description of Actinoplanes friuliensis and description of Actinoplanes nipponensis sp. nov., antibiotic-

producing species of the genus Actinoplanes International Journal of Systematic and Evolutionary


Publications 2013-2018 · catalysis in a 2’-5’ lariat forming ribozyme Journal of the American...

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