PROTEIN PROTEIN THERAPEUTICSTHERAPEUTICS

SUBMITTED BY:AMOL KUNDE-

It is currently estimated that there are 25,000–40,000 different genes in

the human genome, viewed from the perspective of disease

mechanisms, as disease may result

when any one of these proteins contains

mutations or other abnormalities, so it

gives a tremendous opportunity for

Protein therapeutics to alleviate

these disease.

What is Protein therapeutics?

The Evolution of Protein Therapeutics : A Timeline

1953 First accurate model of DNA suggested

1982 Human insulin, created using recombinant DNA technology

1986 Interferon alfa and muromonab-CD3 approved

1997 First whole chimeric antibody, rituximab, and first humanized antibody, daclizumab, approved

1993 CBER's Office of Therapeutics Research and Review (OTRR) formed

2002 Market for biotechnology products represents approximately $30 billion of $400 billion in yearly worldwide pharmaceutical sales

2006 An inhaled form of insulin (Exubera) approved, expanding protein products into a new dosage form.

Classification of protein therapeuticsClassification of protein therapeutics

MAKING THERAPEUTIC PROTEINS

Delivery system

CASE STUDY 1

Case Study: Achieving a cure for HIV infection

Challenges for protein therapeutics:

Futher workFuther work

Complete suppression of plasma HIV-1 RNA should be the goal in all patients with HIV given the availability of new drugs

Maximize virus suppression while minimizing drug toxicity

For those who do not tolerate new agents, goal should be to maintain CD4 count as high as possible

Second line therapy should be chosen on the basis of resistance testing, treatment history, tolerability

ReferenceReference

Benjamin Leader, Quentin J. Baca and David E. Golan; Protein therapeutics: asummary and pharmacological classification. Nature review, volume 7, January2008

Bange, J; Zwick E, Ullrich A. (2001). "Molecular targets for breast cancer therapy andprevention". Nature Medicine 7 (5): 54552

Dipak S. P., Matthew P. K., Sathy V. B., “DELIVERY OF THERAPEUTICPROTEINS”, J Pharm Sci. 2010 June; 99(6): 2557– 2575

WEB SOURCES:http://www.marketresearch.com/RNCOS-v3175/Global-Protein-Therapeutics-6430009/

http://www.pharmaphorum.com/2011/10/11/global-protein-therapeutics-market-beefing-up-towards-futuristic-growth/