Proposed d ch-e_ pg-BIOCHEMICAL ENGG

NATIONAL INSTITUTE OF TECHNOLOGY

DEPARTMENT OF CHEMICAL ENGINEERING

TIRUCHIRAPPALLI, 620 015

PROPOSAL FOR CONDUCTING NEW M.TECH. DEGREEP COURSE IN

BIOCHEMICAL ENGINEERING

2004 - 2005

(JANUARY, 2004)

SUBMITTED TO

MINISTRY OF HUMAN RESOURCE DEVELOPMENT

DEPARTMENT OF EDUCATION

GOVERNMENT OF INDIA

NEW DELHI- 110 001

Chemical Engineering - Biochemical Engineering 2

3.8 ACTIVITY : INTRODUCTION OF NEW COURSES UNDER TEQIP-2003

PROPOSAL FOR STARTING A NEW P.G. COURSE IN

EMERGING AREA OF BIOCHEMICAL ENGINEERING

AT THE DEPARTMENT OF CHEMICAL ENGGINEERING, N.I.T.T

Proposed By: Dept. of Chemical Engineering

Justification for the course

a) Biochemical engineering is the process engineering component of biotechnology

and is an emerging area of importance .It contributes significantly to many

economic activities of our country such as agricultural productivity, production of

biologicals, antibiotics, bioenergy and environmental protection through

biological waste water treatment and bioremediation of contaminated solids or

land. Training of engineers in this interdisciplinary area would benefit many fields

of human endeavor. There is a good demand for highly qualified and trained

engineers in this field.

Name of the

program Justification

Level

U.G. /

P.G.

Proposed

annual

intake

Year of

starting

Additional

Technical

staff

required

M. Tech

(Chemical

Engineering)

Emerging

Area of

biotechnology P.G. 25 2004

Prof:1 ,A.P:

2

Lect.:4

Technical 4

Table ggg

S.No

Name of the

Department / central

faculty

Name of the

laboratory

Total

requirements

(Rs. Lakhs)

Details

Annexure no Page No

1 Chemical

Engineering

Bioscience

1

2 Bioprocess

3 C R E


ANNEXURE -1

DEPARTMENT OF CHEMICAL ENGINEERING - M. Tech- Biochemical Eng.

Equipments Required in the Bioscience and Bio Process Laboratories

S.No Name of the

Laboratory

Name of the

equipment with brief

specification

Unit Price

(Rs.in Lakhs)

Quantity

required

Present quantity

available in the

Institution

1 Bio science Spectro colorimeter 0.50 1 N/A

2 Bioprocess Electronic digital

balance

3.75 5 N/A

3 Air oven 0.50 2 N/A

4 Muffle furnace 0.50 2 N/A

5 Soxhlet‟s appartus 0.15 N/A

6 Turbidometer 0.15 1 N/A

7 Flame photometer 1.0 1 N/A

8 Constant temperature

bath

0.25 2 2

9 Ultra centrifuge 5.00 N/A

11 COD apparatus 0.10 1 N/A

12 BOD incubator 0.50 1 N/A

13 Ultrasonicator 0.10 1 N/A

14 Microfiltration

Membrane device

4.00 1 N/A

15 Densitometer 2.00 1 N/A

16 Vortex mixer 0.20 1 N/A

17 Vacuum oven 0.30 1 N/A

18 Air curtains 0.10 10 N/A

19 Blender 0.20 1 N/A

20 Homogenizer 3.00 1 1

21 Colony counter 0.10 1 N/A

22 De humidifier 0.20 2 N/A

23 Polarimeter 0.5 2 1

24 Water and soil

analyser

0.5 1 N/A

25 Vacuum pumps 0.15 3 1

26 Glasswares 1.00

27 Chemicals 2.00

28 Deep Freezer 1.00 1

Total 27.75


List of equipments coating above Rs. 5 lakhs

S.No Name of the

Department

Name of the

equipment with

brief

specification

Unit

price

(Rs.

lakhs)

Quantity

required

Present

quantity

available

in the

institution

Utilization

in

hours/week

of present

equipment

1 Chemical

Engg.

UV- visible

spectrophotometer

with CRT screen

20.00 1 N/A

2 Inoculation

chamber

10.00 1 N/A

3 Autoclave 5.00 N/A

4 Ion

chromatography

15.00 1 N/A

5 Differential

Scanning

Calorimeter

(Fourier Analysis)

25.00 1 N/A

6 Digital

Polarimeter

5 1 N/A

7 Four- plate Hot

plate / Strirrer

6.5 3 N/A

8 Fat Determination

System (Non

gravimetric)

8 1 N/A

9 Modular

Rheometer

7.5 1 N/A

10 Near IR Liquid

Fuel Analyser

6 1 N/A

11 Thin layer

chromatography

10.00 1 N/A

12 pH meter 10.0 2 N/A Total 128

.


3.5 Modernization and Strengthening of Departmental Laboratories and

Workshops.

Project Oriented Laboratory for Bio-catalytic Reaction Engineering and

Environmental Water Pollution Control:

Enhancing facilities for projects on Immobilized Bio-catalytic Systems and

Enzyme Engineering Studies

Studies on industrial wastewater treatment methods including biological

wastewater treatment.

Design and Modeling and simulation of Bioreactors.

The modernization of Bio – catalytic Reaction Engineering Laboratory is required for

training the U.G. and P.G. students to advanced and industry oriented problems as

project works and will also enhance the R & D activity leading to Doctoral

programmes and increase research work in this area among the faculty

S.No Name of the

Department

Name of the

equipment

with brief

specification

Unit

price

(Rs.

lakhs)

Quantity

required

Present

quantity

available

in the

institution

Utilization

in

hours/week

of present

equipment

1 Chemical

Engg.

Supercritical

fluid extraction

&

chromatography

systems

20.00 1 1 N/A

2 Lab. Scale

Fluidized bed

reactor with

internal

circulation loop

25.00 1 1 N/A

3 Inoculation

chamber

10.00 1 N/A

4 Autoclave 5.00 1 N/A

5 Ion

chromatography

25.00 1 1 N/A

6 Total Sulphur

Analyser

6.00 1 1 N/A

7 Metering

pumps

7.00 5 1 N/A

Total 98.00


.

Category of Items : Text and Reference Books for Bio Chemical Engineering

Name of the Author

(Publishers) Title

Unit Cost

Rs.

No of

copies

required

Robert H.Perry and

Don. W.Green,

Mcgraw-Hill

Perry‟s Chemical Engineer, Platinum

Edition, The Reference Collection 2600 1

Johan Stichlmair et al,

John Wiley & sons,

1998

Bio Technology : Principles and

Practice 6296.5 1

W.R.Vieth,Wiley-

Interscience reissue

edition,1993

Membrane Systems: Analysis &

Design: Applications in

biotechnology

5750.0 1

A.S. Grandison & M.J.

Lewis

Separation Process in the food and

Biotechnology Industries 7000 1

T.K.Ghose (Ed.)

(1994) Tata McGraw

Hill Publ.Co

Process Computations in

Biotechnology 450 1

Joseph P. Reynolds

(Author), et al

Handbook of Chemical and

Environmental Engineering

Calculations

750 1

David T. Allen

(Author), David R.

Shonnard

Green Engineering: Environmentally

Conscious Design of Chemical

Processes

2000 1

Anurag S. Rathore

(Editor), et al (2003)

Scale-Up and Optimization in

Preparative Chromatography:

Principles and Biopharmaceutical

Applications (Chromatographic

Science, Vol 88)

2500 1

Stuttgart

Biochemical engineering 7200 1

T. K. Ghose (Editor),

P. Ghosh (Editor)

Biotechnology in India (Advances in

Biochemical Engineering/

Biotechnology), vol 84 and 85

2460 2

T. H. Scheper New Trends and Development in

Biochemical Engineering

1300

1

K. Schugerl (Editor)

Relation Between Morphology and

Process Performances (Advances in


/Biotechnology), Vol 60

7250 1


Category of Items : Text and Reference Books

Name of the Author

(Publishers) Title

Unit Cost

Rs.

No of

copies

required

Jens Nielsen, et al

Metabolic Engineering (Advances in

Biochemical Engineering/

Biotechnology, 73)

5000 1

T. Scheper (Editor), et

al

History and Trends in Bioprocessing

and Biotransformation (Advances in

Biochemical Engineering /

Biotechnology, 75

5000 1

K. Schugerl (Editor),

A. -P. Zeng (Editor)

Tools and Applications of

Biochemical Engineering Science

(Advances in Biochemical

Engineering/Biotechnology, 74)

4680 1

Wolfgang Babel ,

Alexander Steinbüchel

Biopolyesters. With contributions by

numerous experts (Advances in


Biotechnology Vol. 71

8000 1

K. Faber (Editor), T.

Scheper (Editor)

Biotransformations (Advances in

Biochemical E ngg /Biotechnology ,

Vol 63

5400 1

T. Scheper (Editor)

New Products and New Areas of

Bioprocess Engineering (Advances

in Biochemical

Engineering/Biotechnology, 68

4264 1

Harvey W. Blanch,

Douglas S. Clark Biochemical Engineering 2502 1

A. Constantinides,

W.R. Vieth (Editor) Biochemical Engineering II 2750 1

A. Fiechter (Editor), T.

Scheper

Modern Biochemical Engineering

(Advances in Biochemical

Engineering/Biotechnology, Vol 46)

5000 1


.

Category of Items : Text and Reference Books 1

Name of the Author

(Publishers) Title

Unit Cost

Rs.

No of

copies

required

H. C. Vogel (Editor)

Fermentation and Biochemical

Engineering Handbook: Principles,

Process Design, and Equipment

3150 1

Henry R. Bungay

(Editor), Georges

Belfort (Editor)

Advanced Biochemical Engineering 1900 1

Total


M. Tech. DEGREE

(BIOCHEMICAL ENGINEERING)

SYLLABUS FOR

CREDIT BASED CURRICULUM

(24 months duration)

2004 - 2005

Department of Chemical Engineering

NATIONAL INSTITUTE OF TECHNOLOGY

TIRUCHIRAPPALLI - 620 015.


M. Tech. (Bio-chemical Engineering) COURSE CURRICULUM

Code & Name of the subject Hours per week Credits Evaluation (Marks)

Semester - 1 L T P C.A. S.E. Lab. Total

MBC 101Microbiology 3 3 50 50 100

MBC 102 Biochemistry 3 3 50 50 100

MBC 103 Biochemical Eng. 3 3 50 50 100

MBC 104 Bio reaction Eng. 3 3 50 50 100

Elective - I 3 3 50 50 100

MBC 108 Bioscience Lab 9 3 50 50 100 100

Total Credits in Semester 1 = 18

Name of the subject Hours per week Credits Evaluation (marks)

Semester - 2 L T P C.A. S.E. Lab. Total

MBC 201 Bioprocess Equip-

Design

3 3 50 50 100

MBC 202 Bioprocess -

Instrumen- Control

3 3 50 50 100

MBC 203 Bioprocess Model -

simulation

3 3 50 50 100

Elective - II 3 3 50 50 100

Elective - III 3 3 50 50 100

MBC 208 Bioprocess

Laboratory

9 3 50 50 100 100


Semesters- 3 Hours per week Credits Evaluation (marks)

Name of the subject L T P C.A. S.E. Lab. Total

Elective IV 3 3 50 50 100

Elective V 3 3 50 50 100

Elective VI 3 3 50 50 100

Project Work 6 50 50 100


Semesters -4

Project Work

12

50

50

100



Total Credits in the Course = 63

CODE NO:

M. Tech: Biochemical Engineering

TITLES OF CORE SUBJECTS

Page Number

MBC 101

Microbiology 4

MBC 102

Applied biochemistry 5

MBC 103

Bioprocess Engineering 6

MBC 104

Bio reaction Engineering 7

MBC108

Bioscience Laboratory 8 - 9

MBC 201

Bioprocess equipment Design 10

MBC 202

Bioprocess Instrumentation and Control 11

MBC 203

Bioprocess Modeling and Simulation 12

MBC 208

Bioprocess Laboratory 13

CODE NO: TITLES OF ELECTIVE SUBJECTS

MBC E 01

Separation & Analytical Techniques

14

MBC E 02

Recombinant DNA Technology

15

MBC E 03

Food Processing Technology

16

MBC E 04

Enzyme Engineering

17

MBC E 05

Plant Cell Culture

18

MBC E 06

Environmental Biotechnology

19

MBC E 07

Pharmaceutical Technology

20

MBC E 08

Applied Bio-informatics

21

MBC E 09

Animal Cell Technology

22

MBC E 10 Bioenergy 23


MBC 101 INDUSTRIAL MICROBIOLOGY

1. WORLD OF MICROORGANISMS Characteristics of microorganisms. Historical review of the Foundation of Microbiology.

Taxonomy methods of studying microorganisms. Microscopy, Light and Laser optic systems.

General structural organisation of bacterial, viral, bacilli, Actinomycetes, Differentiation and

development.

2. REPLICATION OF MICROORGANISMS & MICROBIAL NUTRITION Multiplication of bacteriophages, bacteria and differentiating organisms such as yeast, fungi and

actinomycetes. Growth of microorganisms in different media. Growth curve of microbes and

different methods of enumeration of multiplying microorganisms.

3. MICROBIAL METABOLISM Metabolic pathways and bioenergetics. Aerobic and Anaerobic growth. Production of primary and

secondary metabolites and their application in Industry. Beneficial Microorganisms and products.

4. PHYSICAL & CHEMICAL CONTROL OF MICROORGANISMS Chemotherapy -Antimicrobial agents and disinfectants - Diseases caused by microorganisms and

control.

5. ENVIRONMENTAL APPLICATIONS OF MICROBIOLOGY

Ecology - Re-cycling of Biomaterials. Production of Biogas - Leaching of ores by

microorganisms - Application of Biofertilizers and Bio pesticides - Pollution control through use

of consortium of microorganisms.

TEXT BOOKS :

1. Pelczar M.J., Chan E.C.S., Krieg, N.R. “Microbiology”, 5th

Edition, 1986,Tata McGraw-Hill

Book Co., New Delhi.

2. Schlegel H .G., General Microbiology, 7th Edition, 1994. C L P Edition, Cambridge University

Press, U.K.

3. Introductory Microbiology, J. Heritage, E. G. V. Evans and R. A. Killington, 1996, C L P Edition,

Cambridge University Press, U.K.

4. Microbiology: A text book for University Students by P.D. Sharma, Rastogi Publications

”Gangotri”, Shivaji Road, Meerut 250 002


MBC 102 APPLIED BIOCHEMISTRY

1. INTRODUCTION TO BIOMOLECULES

Structure and properties of Mono, Di, oligo and polysaccharides; Complex carbohydrates;

Structure and properties of Fatty acids; Structure and properties of amino acids, peptides, proteins

and conjugated proteins:

2. NUCLEIC ACIDS

Structure and properties of purines, pyrimidines, nucleosides, nucleotides, polynucleotides;

Ribonucleic acids, and deoxyribonucleic acids.

3. METABOLISM

Biosynthesis and degradation of fatty acids and cholesterol; amino acids and proteins; Purines,

pyrimidines and nucleic acids.

4. INTERMEDIARY METABOLISM

TCA cycle, glycolysis, gluconeogenesis, Pentose phosphate shunt; EMP, Urea cycle,

Interconnection of pathways; Metabolic regulation; Bioenergetics; Respiratory chain, ATP cycle,

energy rich compounds.

5. STRUCTURE FUNCTION RELATIONSHIP

Complex carbohydrates, proteins and nucleic acids

Text Books :

1. A. L. Lehninger, D.L.Nelson and M .M. Cox; “Principles of Biochemistry” CBS

Publications, 1993.

2. L. Stryer; “Biochemistry” W. H. Freeman (IV Ed.) 1995.

3. E .E. Conn and P.K. Stumpf and others. Outlines of Biochemistry, (V Ed.), 1987,

John Wiley & Sons, Singapore.

4. Sawhney. S. K. and Randhir Singh (Editors), Introductory Practical

Biochemistry, Narosa publishing House, New. Delhi. 2000, ”Gangotri”, Shivaji

Road, Meerut 250 002


MBC 103 BIOPROCESS ENGINEERIN

1. INTRODUCTION: FERMENTATION PROCESSES General requirements of fermentation processes - An overview of aerobic and anaerobic

fermentation processes and their application in industry - Medium requirements for fermentation

processes - examples of simple and complex media - Design and usage of commercial media for

industrial fermentation - Sterilization :Thermal death kinetics of microorganisms - Batch and

Continuous Heat-Sterilization of liquid Media - Filter Sterilization of Liquid Media and Air. 8

Hours

2. ENZYME TECHNOLOGY, MICROBIAL METABOLISM: Enzymes: Classification and properties-Applied enzyme catalysis - Kinetics of enzyme catalytic

reactions - Metabolic pathways - Protein synthesis in cells. 8 Hours

3. STOICHIOMETRY AND KINETICS OF SUBSTRATE UTILIZATION AND

BIOMASS AND PRODUCT FORMATION:

Stoichiometry of microbial growth, Substrate utilization and product formation-Batch

and Continuous culture, Fed batch culture

8 Hours

4. BIOREACTOR AND PRODUCT RECOVERY OPERATIONS: Operating considerations for bioreactors for suspension and immobilised cultures, Selection,

scale-up, operation of bioreactors-Mass Transfer in heterogeneous biochemical reaction systems;

Oxygen transfer in submerged fermentation processes; oxygen uptake rates and determination of

oxygen transfer rates and coefficients; role of aeration and agitation in oxygen transfer. Heat

transfer processes in Biological systems. Recovery and purification of products. 8 Hours

5. INTRODUCTION TO INSTRUMENATION AND PROCESS CONTROL IN

BIOPROCESSES: Measurement of physical and chemical parameters in bioreactors- Monitoring and control of

dissolved oxygen, pH, impeller speed and temperature in a stirred tank fermentor.

8 Hours TEXT BOOKS.

1. M.L. Shuler and F. Kargi," Bio-process Engineering", Prentice Hall Inc., New Jersey. 1992.

2 J.E. Bailey and D.F. Ollis," Biochemical Engineering Fundamentals", 2nd

Edn., McGraw Hill,

Publishing Co. New York., 1985.

REFERENCES:

1. P.Stanbury, A. Whitakar and S. J. Hall "Principles of Fermentation Technology" 2nd

Edn.,

Elsevier-Pergamon Press, 1995.


MBC 104

BIOCHEMICAL REACTION ENGINEERING

1. STOICHIOMETRIC OF A BIOPROCESS:

Elemental analysis and empirical formula for cells- Substrate consumption for biomass

formation, energy and product formation- Yield coefficients for biomass and product

formation- Uses of material and energy balances.

2. IDEALIZED REACTOR TYPES:

Basic types of bioreactors - Reactor circuits - Dispersion models- Reactor

Combinations - Partial Cell recycle

3. KINETICS OF CELL GROWTH AND PRODUCT FORMATION IN

IDEALIZED BIOREACTORS:

Qualitative description of growth and product formation. Growth models. Product formation.

Growth in idealized bioreactors. Non-limited and substrate limited growth. Oxygen limited

growth Model extension by death and maintenance term. Air lift reactor.

4. KINETICS OF IMMOBILIZED IOCATALYSTS AND REACTOR

CONFIGURATIONS:

Effect of external diffusion limitation in attached film particle- Effect of Internal diffusion

limitation in gels and Pores - Configurations for Immobilized Enzyme Reactors: Batch

stirred – continuous stirred tank-plug flow- packed beads- liquid-solid and three phase

expanded / fluidised bed reactors-membrane bioreactor

5. BIOREACTOR DESIGN & PRODUCT YIELD:

Strategies for Scale up for CSTR, Batch reactor, Plug flow reactor, Packed bed reactor and

fluidised bed reactor, Strategies for sterilization

Text books:

1. Karl Schugerl, “Bioreaction Engineering” Volume I, (1985), John

Wiley, New York.

2. Biochemical Reaction Engineering, R. Lovitt and M. Jones, Chapter 5 in

Chemical Engineering Vol 3, (third Edition), Richardson and Peacock,

1994, Asian Books (pvt) Ltd, N. Delhi.

3. Scragg, “Bioreactors in Biotechnology - A Practical Approach” (1991), Ellis

Horwood Ltd., U.K.


MBC 108 BIOSCIENCE LABORATORY

PART A

1. Centrifugation: Differential and gradient centrifugation. Isolation of sub-

cellular organelles and particles

2. Chromatography: Use of paper chromatography in separation of amino

acids.

Gel filtration chromatography, Gas-liquid chromatography

3. Adsorption & Ion-exchange: Separation of amino acids by ion exchange

chromatography, Separation of leaf pigments by adsorption chromatography

4. Electrophoresis in Agarose and SDS gels:

5. Membrane separation of Proteins

6. Estimation of Carbohydrates

7. Estimation of Vitamins

Reference books:

1. Plummer. D. T., “An introduction to Practical Biochemistry” 3rd Edn, (1987),

Tata McGraw Hill Publishing Co, N. Delhi.

2. Jayaraman.J, Laboratory Manual in Biochemistry, (1992), New Age

International (P), Ltd., New Delhi.

3. Sawhney. S. K. and Randhir Singh (Editors), Introductory Practical

Biochemistry, Narosa publishing House, New. Delhi. 2000, ”Gangotri”,

Shivaji Road, Meerut 250 002


MBC 108 BIOSCIENCE LABORATORY

PART B

1. Maintenance and Identification of microorganisms

2. Biochemical Characterisation.

3. Methods of quantification of microorganisms from soil, air and water.

4. Fermentation: Growth curve in Shake flask and Bioreactors,

Reference Books :

1.Collins and Lyne, “Microbiological Methods” 5th

Edn.

(1986), Butterworths, Singapore

2.Laboratory Manual in Microbiology. P. Gunasekaran

(1995), New Age International (P) Ltd., N. Delhi.

3. Microbiology:A textbook for University Students, P. D. Sharma, Rastogi

Publications,


MBC 201 BIOPROCESS EQUIPMENT DESIGN

Faculty Member: Dr. P. Sivashanmugam

OBJECTIVE: The course will equip the students to design bioprocess systems

1. MECHANICAL DESIGN OF BIOREACTORS:

Basic design and construction of a fermenter and its ancillaries, Vessel geometry. Materials of

construction.

2. MECHANICAL DESIGN OF ANCILLARY EQUIPMENT:

Bearing assemblies, Motor Drives; Aseptic Seals; Flow Measuring devices; Agitator and Sparger

design; Piping and Valves for Biotechnology Plants.

3. SUPPORT AND UTILITY SYSTEMS:

Pumps; Cartridge filtration and Pressure Relief; Sterilization of process equipment; Utilities for

biotechnology Plants: Heating, Ventilating and Air Conditioning.

4. PROCESS DESIGN AND OPERATION OF BIOREACTORS:

Operational Modes of Reactors - Batch, Continuous, Fed-batch, Repetitive Batch, Recycle and

Continuous cultivation; Novel Bioreactors; Stirred Tank, Air lift and Loop reactors, Packed bed

and Hollow fibre Membrane Bioreactors; Scale-up criteria for bioreactors.

5. BIOPROCESS ECONOMICS:

Bio-product regulation; General fermentation process economics; Examples - Fine chemicals, Bulk

oxygenates, Single-cell protein, Anaerobic Methane production.

TEXT BOOKS :

1. Bioprocess Engineering: Systems Equipment and Facilities, Edited by B.K.Lederson, N.A.D‟elia

and K.L.Nelson (1994), John Wiley and Sons, N.Y.

2. Process Equipment Series, No5: Transfer Operations in Process Industries- Design and Equipment,

Edited by M .V. Bhatia, (1994), Technomic Publ. Co., Lancaster, Pennsylvania, USA.

REFERENCES:

1. Atkinson, B. & Mavituna, F. “Biochemical Engineering & Biotechnology Handbook”, (2nd

Edn.),

1993, McGraw Hill, N.York.

2. H.J. Rehm and G, Reed (ED.) Biotechnology-. Volume 3, (2nd

Ed), 1993, VCH, Berlin.

3. McNeil and Harvey, “Fermentation - A Practical Approach” (1990), IRL Press, U.K.

4. Scragg, “Bioreactors in Biotechnology - A Practical Approach” (1991). Ellis Horwood Ltd , U.K.


MBC 202

BIOPROCESS INSTRUMENTATION & CONTROL

1. SENSORS:

Physical and chemical sensors; Biosensors; On-line sensors for cell properties; off-line Analytical

methods.

2. MEASUREMENT OF FERMENTATION PARAMETERS:

Agitation and capacity coefficient in fermenters; Control of pH, dissolved

oxygen, dissolved carbon dioxide, temperature of fermenters; Rheological

measurement and control application of microcomputers in the study of

microbial process.

3. COMPUTERS AND INTERFACES:

Elements of Digital computers; Computer Interfaces and peripheral devices; Fermentation

software systems

4. DATA ANALYSIS & PROCESS CONTROL:

Data smoothing and interpolation; State and parameter estimation; Direct regulatory control;

cascade control of metabolism.

5. ADVANCED CONTROL STRATEGIES:

Programmed batch bio-rection; Design and operation strategies for batch plants; Continuous

process control.

TEXT BOOKS:

1. Bailey J.E. and Ollis,D.F. “ Biochemical Engineering Fundamentals” 2nd

Edition, (1986),

McGraw Hill Book CO.,Singapore.

2. T.K.Ghose (Ed.) “Process Computations in Biotechnology” (1994) ,Tata McGraw Hill

Publ.Co.,N.Delhi.

3. A.Fischer (Ed.), “Advances in Bio Chemical Engineering ” Vol. 13, 1973,

Springer Verlag, Germany

REFERENCES:

1. Aiba, Humphry and Millis, “ Bio Chemical Engineering ”, 2nd

Ed., (1973), Academic press

2. McNeil and Harvey, “Fermentation - A Practical Approach” (1990). IRL Press , U.K.

3. Scragg, “Bioreactors in Biotechnology - A Practical Approach” (1991),Ellis Horwood Ltd.,U.K.


MBC 203

MODELLING AND SIMULATION OF BIOPROCESSES

1. MODELING PRINCIPLES Basic modelling principles; Mathematical models for chemical engineering systems. Analog

simulation; Digital simulation; Time-domain dynamics; Laplace-domain dynamics; Frequency-

domain dynamics; Process identification.

2. MODELLING AND DESIGN OF BIORECATORS Modelling of Non-Ideal Behaviour in Bioreactors - Tanks -in-series and Dispersion Models -

application to design of Continuous sterilizers and other first order processes; Design and analysis

of packed bed and membrane biorectors; Recombinant Cell culture processes.

3. MONITORING OF BIOPROCESSES On-line data analysis for measurement of important physico-chemical and biochemical parameters;

State and parameter estimation techniques for biochemical processes.

4. SIMULATION OF BIOPROCESSES Software packages for simulation of Bioprocesses - MATLAB-SIMULINK,SIMNON, ISIM;

Simulation of Bioprocesses using models from literature sources.

5. SIMULATION OF PLANTS Simulation techniques in process design and integrated chemical plants and processes. Application

of simulation packages.

TEXT BOOKS:

1. Modelling and Control of Fermentation Processes, Edited by J.R. Leigh,

(1987), Peter Peregrinus, London.

2. Luyben W.L., “Process Modelling, Simulation And Control For Chemical

Engineers” 2/e,McGraw Hill International edition, 1990.

3. Process Computations in Bio-technology, T. K. Ghose (Editior), Tata Mcgraw Hill publ. Co., N.

Delhi.

REFERENCES: 1. Modelling and Optimisation of Fermentation Processes, Edited by B. Volesky

and J. Votruba, (1992) , Elsevier, Amsterdam

2. Smith C.A. and Corripio A.B., “Principles and Practice of Automatic Process

Control “, 1985, John Wiley & and Sons.

3. Morton M. Denn, “Process Modelling” , 1986, Longman Scientific &

Technical, England.

4. McNeil and Harvey, “Fermentation - A Practical Approach” (1990), IRL

Press., U.K.


MBC 208 BIO-PROCESS LABORATORY

PART A

1. Growth kinetics of bacteria, fungi.

2. Fermentation studies - Batch, fed-batch and Continuous cultivation

3. Solid state fermentation Techniques

4. Centrifugation,

5. Spray Drying

6. Freeze Drying

REFERENCE BOOKS :

1. Laboratory Manual in Microbiology, P.Gunasekaran, 1995, New Age

International (P) ,Ltd .N. Delhi.

2. Experiments in Microbiology ,Plant Pathology and Tissue Culture., K .R. Aneja,

1993, New Age International (P), Ltd ,N Delhi.

PART B

1. Gas analysis calculations and interpretations

2. Analytical techniques for estimation of glucose, ethanol, glutamate, acetate and

other metabolites

3. Modelling and Simulation of fermentation Process (Computer Lab)

Reference book:

1. McNeil and Harvey, “Fermentation - A Practical Approach” (1990), IRL

Press., U.K.


LIST OF ELECTIVES

MBCE 01

SEPARATION AND ANALYTICAL TECHNIQUES

1. INTRODUCTION TO BIOSEPARATION Characterisation of Biomolecules and fermentation broths; Role of downstream processing in

biotechnology; Broad strategies for design of bio-separation processes.

2. CELL DISRUPTION, SOLID-LIQUID AND MOLECULAR SIZE-BASED

SEPARATIONS Cell disruption - Mechanical and Chemical methods; Cake filtration and micro-filtration;

Centrifugation and sedimentation. Membrane processes - Dialysis, Ultra-filtration, Reverse

osmosis and Electro-dialysis.

3. LIQUID-LIQUID SEPARATIONS AND PROTIEN SEPARATIONS Solvent extraction of small molecules; Aqueous two-phase extraction of proteins; Precipitation of

proteins with salts and with organic solvents

4. ADSORBPTION AND CHROMATOGRAPHIC SEPARATIONS Adsorption processes - Principles of chromatographic separation - gel filtration, reversed-phase,

hydrophobic interaction, ion-exchange, IMAC and bio-affinity chromatography - Design and

selection of chromatographic matrices - Modes of operation; Design of Large-scale

chromatographic separation processes - Electrophoretic Separation processes.

5. FINAL PRODUCT PURIFICATION AND PREPARATION Crystallization - Drying and Lyophilization - Formulation Strategies.

TEXT BOOKS:

1. J .Asenjo (Ed.) “Separation Processes in Biotechnology” (1993), Marcel-Dekker .

2. Verrall, M.S. and Hudson, M.J. “Separations for Biotechnology” (1990) Ellis Horwood.

3. Paul A Belter, E. L .Cussler and Wei Shan Hu “Bioseparation - Downstream Processing for

Biotechnology” (1988). Wiley Inter Science, N.York.

4. “Product Recovery in Bioprocess Technology” BIOTOL Series, (1992) , Butterworth

Heinemann .U.K.


MBCE 02

RECOMBINANT DNA TECHNOLOGY

1. BASICS OF RECOMBINANT DNA:

Role of genes within cells; elucidation of the genetic code; genetic elements that control gene

expression.

2. VECTORS FOR RECOMBINANT CELLS:

Plasmids, Cosmids, Phage vectors. Plasmids for production of bio-products

3. PRODUCTION OF RECOMBINANT DNA MOLECULES:

Methods of creating recombinant DNA molecules; restriction enzymes and mapping of DNA;

Plasmid and phage vectors.

4. APPLICATIONS OF RECOMBINANT DNA TECHNOLOGY:

Production of products from recombinant cells; Cloning in plants - Ti plasmid of Agrobacteria;

Transgenic animals.

5. ETHICAL ASPECTS ON USE RECOMBINANT DNA TECHNOLOGY:

Recombinant products - a bane or boon to society; safety guidelines of recombinant DNA research

and production; Successful recombinant DNA processes for production of high-value metabolites.

TEXT BOOKS:

1. Old R.W. and Primrose, S .B., “Principles of Gene Manipulation” Blackwell Scientific

Publications, 1983.

2. Milestones in Biotechnology, Edited by J .Davies and W .S. Reznikoff (1992), Butterworth

Heinemann, U.K

3. Desmond. S.T .Niccholl, ” An Introduction to Genetic Engineering “,1994,C L P Edition,

Cambridge University Press, U.K.


MBCE 03

FOODPROCESSING TECHNOLOGY

1. INTRODUCTION:

Biotechnology in relation to the food industry; Nutritive value of food; types of microorganisms

associated with food, its sources, types and behavior in foods.

2. FOOD PRESERVATION:

Preservation of meat, Fisheries, Vegetables, dairy products; Enzymes and Chemicals used in food

processing,. Thermal inactivation of micro-organisms; Thermal process evaluations; Freezing and

thawing of foods.

3. FERMENTED FOOD PRODUCTS:

Dairy products, meat, fishery, non beverage plant products, Beverages and related products of

baking.

4. FOOD SPOILAGE:

Food borne illness, quality control. Case studies on Biotechnology in the evolution of food quality,

HFCS (High fructose corn syrup) and Myco-proteins.

5. FOOD PROCESSING OPERATIONS:

Rheology and Fluid flow; Calculation of power requirements for pumping of food materials;

Material and energy balances in Food processing; Thermal processing of food; Microwave

heating; Biochemical engineering for flavor and food production

REFERENCES:

1. George J Banward, “Basic Food Microbiology” (1987), CBS Publishers , N.Delhi.

2. R .Angold, G .Beech and J. Taggart," Food Biotechnology", 1989, Cambridge University Press,

U.K.,

3. Lindsay, “Biotechnology challenges for the flavour and food industry” (1988), Elsevier Applied

Science

4. H.G.Muller,” An Introduction to Tropical Food Science”,1989,C L P Edition, Cambridge

University Press, U.K.


MBCE 04 ENZYME ENGINEERING

1. APPLICATION OF ENZYMES:

Classification of Enzymes, Commercial applications of enzymes in food, pharmaceutical and other

industries; enzymes for diagnostic applications.

2. IMMOBILIZATION TECHNIQUES:

Merits and demerits; Carrier types; Techniques of Immobilization; Fields of Application -

Immobilized enzymes as process aids and as analytical tools; Immobilization of co-enzymes-

Interaction - Chemical synthesis-Characterisation of coenzyme- analogues exploitation of binding

properties of coenzyme. Metal based Enzyme Crosslinking and Stabilization. Analysis of Film and

Pore Diffusion Effects on Kinetics of Immoblilized Enzyme Reactions; calculation of

Effectiveness Factors of IME systems

3. KINETICS AND MECHANISM OF ENZYME ACTION:

Kinetic Models; Types of Inhibitions; Inhibition kinetics; Modeling of rate equations for single and

multiple substrate reactions.

4. DESIGN OF ENZYME REACTORS:

Design and Operation of Ideal reactors - CSTR and PFR; Design of Packed-bed and Fluidised bed

Immobilised Enzyme Reactors; Membrane Reactors for immobilised enzyme systems.

5. DESIGN OF BIOSENSORS: Use of enzymes in analysis - Types of sensing -gadgetry and methods; use of unnatural substrates -

artificial enzymes - enzyme mimicking. Enzyme Engineering in non-aqueous solvents. Case of

Subtlisin in Polar media. Extemozymes and Abzymes

TEXT BOOKS:

1. “Technological applications of Biocatalysts” BIOTOL Series, 1995, Butterworth Heinemann,

U.K.

2 A. Cornish- Bowden, “Analysis of Enzyme Kinetic data” , 1996, Oxford Univ. Press, U.K.

REFERENCES:

1. Wiseman A (Ed) “Topics in Enzyme and Fermentation Biotechnology” Volume 5, (1991), Ellis

and Harwood , U.K.


MBC E 05 PLANT CELL CULTURE

1. AN OUTLINE ON MOLECULAR BIOLOGY:

DNA Replication, translation, transcription. Fundamentals of recombinant DNA

technology, Gene regulation

2. AGROBACTERIUM & PLANT GENETIC ENGINEERING:

Agrobacterium mediated gene transfer and cloning. Types of plant vectors and

their use in gene manipulation.

3. PLANT VIRUSES:

Classification - diagnosis - remedy - viruses as a tool to deliver foreign DNA.

4. MOLECULAR BASIS OF DISEASE SUSCEPTIBILITY & RESISTANCE:

Transposable elements, Factors influencing disease resistance and susceptibility

RFLP.

5. TRANSGENICS:

Herbicide tolerance - insect resistance - viral resistance - stress tolerance -

Development of disease resistant plants by introducing B.t genes.

TEXT BOOKS & REFERENCES:

1. S. H. Mantell, J. A. Mathews, R.A. Mckee., “ Principles of Plant Biotechnology -

An Introduction to Genetic Engineering in Plants” Blackwell Scientific

Publications, 1985.

2. Dodds, J. H. “ Plant Genetic Engineering ” 1985, Cambridge University Press,

U.K.

3. J. Holden, J. Peacock, T. Williams, (Ed.), Genes, Crops and the Environment,

1993, C L P Edition, Cambridge University Press, U.K.

4. J.G .Manners,” Principles of Plant Pathology”, 2nd

Ed., 1993, C L P Edition,

Cambridge University Press, U. K.

5. Dodds, J.H., and L.W. Roberts, (1985), Experiments in Plant Cell Culture (2nd

Ed.), Cambridge University Press., U.K.

6. Advances in Biochemical Engg./Biotechnology, Vol. 31,(1985), Plant Cell

Culture., Springer Verlag, Germany.


MBCE 06 ENVIRONMENTAL BIOTECHNOLOGY

1.WATER POLLUTANTS: SOURCES, EFFECTS, MONITORING AND

QUALITY STANDARDS:

Water Pollution Sources and Classification of water pollutants - Water pollution laws

and standards - Water pollution and health - Wastewater sampling and analysis. -

BOD, COD of wastewater - monitoring - Compliance with Standards.

8 hours

2.ANAEROBIC PROCESSES FOR B O D REDUCTION:

Anaerobic Digestion: Microbial And Biochemistry Aspects. High Rate Attached

Film Digesters. Sludge Disposal

8 hours

3.AEROBIC PROCESSES FOR B O D REDUCTION:

Aeration requirements - Microbial factors -Activated sludge and Attached film

processes.

8 hours

4.ADVANCED WASTEWATER AND WATER

TREATMENT: Carbon Adsorption - Ion Exchange - Membrane Processes - Nutrient (nitrogen and phosphorus)

removal- Design of plant for treatment and disposal of sludge

8 hours

5. SOLIDS WASTE AND LANDFILL MANAGEMENT:

Sources and classification - methods of solid waste disposal - Composting (natural) -

Accelerated composting with industrial sludge - Landfill Technology -Methods

adopted for municipal solid waste-Toxic-waste management, Incineration of

industrial waste, Design aspects, economics.

8 hours

Text books:

1. Rittman, B. E. and McCarty, P., Environmental Biotechnology: Principles

and Applications,) McGraw-Hill International Edition, Singapore. (2000)

2. G. Tchbanoglous and F.L. Burton, Metcalf and Eddy‟s Wastewater

Treatment, Disposal And Reuse (Third Edition), Tata McGraw-Hill

publishing Co Ltd, N. Delhi. (1996)

3. A. P. Sincero and G.A. Sincero, Environmental Engineering: A Design

Approach, Prentice Hall of India pvt Ltd, N. Delhi. (1996)

Reference Books:

1. Microbiology for Environmental Scientists and Engineers, A.Gaudy and E.

Gaudy, McGraw Hill International Book Co, N.Y. (1981)

2. D. Barnes and P. J. Bliss , Biological Control of Nitrogen in Wastewater

Treatment, E & F N Spon, London.(1983)

4. Industrial Water Pollution Control, Third Edition, W. W. Eckenfelder Jr,

McGraw-Hill International Edition, Singapore. (2000)


MBCE 07 PHARMACEUTICAL TECHNOLOGY

1. INTRODUCTION

Development of Drugs and Pharmaceutical Industry - Organic therapeutic agents -

uses and economics

2. DRUG METABOLISM AND PHARMACO-KINETICS

Drug metabolism – Physico-chemical principles - Pharma Kinetics - Action of

drugs on human bodies

3. IMPORTANT UNIT PROCESSES AND THEIR APPLICATIONS

Chemical conversion processes - Alkylation - Carboxylation - Condensation and

Cyclisation - Dehydration, Esterification (Alcoholysis) - Halogenation - Oxidation

Sulfonation - Complex Chemical Conversions - Fermentation

4. MANUFACTURING PRINCIPLES

Compressed tablets - Wet granulation - Dry granulation or slugging - Direct

compression - Tablet presses Formulation - Coating - Pills - Capsules sustained

action dosage forms - Parental solutions - Oral Liquids - Injections - Ointments -

Standard hygiene and Good Manufacturing practice.

5. PHARMACEUTICAL PRODUCTS, ANALYSIS AND CONTROL

Vitamins - Cold remedies - Laxatives - Analgesics - External Antiseptics -

Antibiotics - Biologicals - Hormones - Preservation. Analytical methods and tests

for various drugs and pharmaceuticals. Packing Techniques - Quality control.

REFERENCES BOOKS :

1. Remington‟s Pharmaceutical Sciences, Mack Publishing Co, N.Y.

2. Medicinal Chemistry: Principles and Practice, Edited by F.D.King, (1994), The

Royal Society of Chemistry. U.K.

3. The Organic Chemistry of Drug Synthesis,D.Lednicer and L.A.Mitscher

(1977),John Wiley and Sons,N.Y.

4. The Discovery of Natural Products with Therapeutic potential, V.P .Gullo,

Butterworth Heinemann, U.K.

5. Essentials of Medicinal Chemistry , A .Korolkovas and J. H. Burckhalter (1976),

John Wiley and Sons,

N .Y.

1. INTRODUCTION TO INFORMATION TECHNOLOGY

Computers and microprocessors, Storage devices, analysis and information handling

capacity. Informatics applied to Biotechnology: Data acquistion and storage; data

analysis; pattern matching, primary, secondary and tertiary structures of nucleic acids

and protein sequences.

2. NETWORKS AND DATA EXCHANGE

Process of MODEM, PAD, GPSS, networking modes for global data exchange;

local area wide area networks.

3. APPLICATION IN BIOTECHNOLOGY

Sources of nucleic acid and protein sequences - organization of information and

properties in the different data banks.

4. SEQUENCE DATABASE

EMBL, GENBANK, SWISS-PROT, etc., sequence databases

5. ALIGNMENTS

Global Vs Local alignments - Needleman and Wunsch global alignment algorithm - use

of scoring matrices - Use of PAM matrices for allowable amino acid susbstitutions and

detecting evolutionary relationships.

REFERENCES:

1. EMBL, GENBANK, SWISS-PROT Database Sequences.

MBC E 09 ANIMAL CELL TECHNOLOGY

1. INTRODUCTION

What is Biotechnology?; Scope of Biotechnology; Animal Biotechnology

2. MOLECULAR BIOLOGY

Nucleic acids - DNA, RNA, replication, transcription, translation genetic code, gene

regulation, genetic engineering, Plasmid isolation and gene cloning, Identification of

transformants.

3. CELL CULTURE TECHNOLOGY

Culturing of cells, Primary and secondary cell lines and the effect of growth factors, High

technology vaccines, Hybridoma technology.

4. GENETIC ENGINEERING

Enzyme technology, Somatic manipulation of DNA; Nucleic acid hybridisation and

probes in diagnosis; preparation of probes, evaluation and applications

MBCE 08

APPLIED BIOINFORMATICS

5. APPLICATIONS

Rumen manipulation - probiotics - Embryo transfer technology - Invitro fertilization -

Transgenic animals.

REFERENCES:

1. C. A. Babiuk, J.P.Philips and Moo Young,M. “Animal Biotechnology”, Pergamon Press,

New York, 1989

MBCE 10 BIOENERGY

Faculty Member : Dr. H.J.Prabhu.

OBJECTIVE: To Learn about Biomass Conversion methods for energy production by

thermochemical and biochemical techniques and understand the design of gasifiers, combustors and biogas

generators.

1. BIOMASS CHARACTERISTICS & PREPARATION: Biomass sources and classification. Chemical composition and properties of biomass. Energy plantations.

Preparation of biomass: Size reduction, Briquetting of loose biomass, Drying, Storage and handling of biomass.

2. BIOGAS TECHNOLOGY: Feedstock for producing biogas. Aqueous wastes containing biodegradable organic matter, animal residues-

sugar rich materials. Microbial and biochemical aspects and operating parameters for biogas production.

Kinetics and mechanism. Dry and wet fermentation. Digestors for rural application-High rate digestors for

industrial waste water treatment.

3. PYROLYSIS AND THERMO CHEMICAL CONVERSION: Thermo-chemical conversion of ligno-cellulose biomas. Incineration for safe disposal of hazardous waste.

Biomass processing for liquid fuel production. Pyrolysis of biomass-pyrolysis regime, effect of particle size,

temperature, and products obtained.

4. GASIFICATION OF BIOMASS: Thermochemical principles: Effect of pressure, temperature and of introducing steam and oxygen. Design and

operation of Fixed and Fluidised Bed Gasifiers. Safety aspects.

5. COMBUSTION OF BIOMASS AND COGENERATION SYSTEMS: Combustion of woody biomass-theory, calculations and design of equipments. Cogeneration in biomass

processing industries. Case studies: Combustion of rice husk, Use of bagasse for cogeneration.

TEXT BOOKS: 1. A.Chakraverthy, “Biotechnology and Alternative Technologies for Utilisation of Biomass or Agricultural

Wastes”, Oxford & IBH publishing Co., New Delhi, 1989.

2. K.M.Mital, “ Biogas Systems: Principles and Applications”, New Age International Publishers (p) Ltd.,

1996. 3. P.Venkata Ramana and S.N.Srinivas, “Biomass Energy Systems”, Tata Energy Research Institute, New

Delhi, 1996. 4. D.L. Klass and G.M. Emert, “Fuels from Biomass and Wastes”, Ann Arbor Science publ. Inc. Michigan,

1985.

REFERENCES:

1. Khandelwal K.C. and Mahdi, “Bio-gas Technology”, Tata McGraw-Hill pub. Co. Ltd., New Delhi, 1986.

2. O.P. Chawla, “Advances in bio-gas Technology”. I.C.A.R., New Delhi. 1970.

CONTENTS

Proposal and Introduction 2

Self assessment 3

Staff of Department of Chemical Engineering 4

Profile of Department of Chemical Engineering 5

Research Publications 6

Present Laboratory Facilities 8

Computer Networking and facilities 8

Fund Required to upgrade facilities 9

Staff required 9

Information on the Course 10

Annexure1: Copy of AICTE approval letter 14

Annexure 2: Central Grants Utilized for Facilities 19

Annexure 3: Library Facilities Enhanced 20

Annexure 4: Summary of Syllabus 21

PROPOSAL FOR SANCTION FOR CONDUCTING P.G. PROGRAMME OF M.TECH.

DEGREE IN BIOCHEMICAL ENGINEERING AT THE DEPARTMENT OF CHEMICAL

ENGINEERING, REGIONAL ENGINEERING COLLEGE, TIRUCHIRAPPALLI, 620

015, SUBMITTED TO THE MINISTRY OF HUMAN RESOURCE DEVELOPMENT,

DEPARTMENT OF EDUCATION, GOVERNMENT OF INDIA NEW DELHI- 110 001.

MARCH 2002. REF: AICTE APPROVAL TO REGIONAL ENGINEERING COLLEGE DEPT. OF CHEMICAL

ENGINEERING , TIRUCHIRAPPALLI, 620 015, FOR CONDUCT OF P.G. COURSE IN

BIOCHEMICAL ENGINEERING FOR THE ACADEMIC SESSION 2002-2003 FOR THREE YEARS

PERIOD.(VIDE: AICTE LETTER, F.NO.: XVII-AIBPG/APP-1601/ET/2001 DATED FEBRUARY,12,

2002)

1. Name and Full Address of the Institution: Regional Engineering College,

Tiruchirappalli, 620 015

Tamil Nadu

Phone: 0431 - 500 061 extn. 2001

Fax: 0431 – 500 133

Cable : TREC

e-mail: [email protected]

2. Name of the Department: Department of Chemical Engineering

Phone: 0431 – 500 061 extn. 2901

e-mail: [email protected]

3. Conditions and Specific conditions for the AICTE approval of the Project:

[Copy enclosed; see Annexure 1.]

Degree: M.Tech

Course (specialization) : Chemical Engineering (Biochemical Engineering)

Annual Intake: 16

Duration(Full Time): 24 months

Additional 5 (Five) sponsored + 4(four) SC/ST candidates shall be admitted for the above

full time P G Programme.

INTRODUCTION

Bioprocess engineering contributes to many economic activities in our country such

as agricultural productivity, production of biologicals and antibiotics, biological wastewater

treatment, bioremediation for removal of contamination of land etc. Training of engineers in

this area at postgraduate level is necessary and would benefit many fields of human

endeavor. There is a good demand for highly qualified and trained engineers in this field.

SELFASSESSMENT REFLECTING COMPETENCE AND LEVEL

OF INFRASTRUCTURE AVAILABLE: Department of Chemical Engineering has carried out several project works in this

field. The department is equipped with a biochemical engineering laboratory, one stirred

tank bioreactor (BIOSTAT-E) and a fluidized bed bioreactor with instrumentation. It has

some analytical facilities also. The department created the facilities by participating in the

MHRD sponsored schemes like I.I.T. (Madras) – R.E.C.(TRICHY) institutional network

scheme and Central Assistance Programme for Thrust Areas in Technical Education Scheme

(1988-1992), and subsequent projects granted by the AICTE.[See Annexure 2 for funds

utilized for biochemical and other facilities during 1988-2002]

Several projects have been carried out in this department in bioprocess engineering

among which some are applied to environmental pollution problems. Bio-desulfurisation of

di-benzothiophene found in diesel by bacteria was experimentally investigated to confirm the

capacity of this method to remove sulfur from this recalcitrant compound. Other projects

include three phase fluidized bed bioreactor for aerobic effluent treatment, bio-denitrification

of effluent and biodegradation of animal glue. A study on production of an important amino

acid has been carried out using a fluidized bed bioreactor for bacteria immobilized on beads.

Similar work on production of enzymes has been carried out.

A good number of reference volumes on Biotechnology/Biochemical Engineering

were added to our library. Back volumes of one journal were procured and three journals

were subscribed to from the funds provided. [See Annexure 3]

Currently one semester theory course on biochemical engineering are being taught to

U.G./ P.G. students of chemical engineering degree courses. Project works are carried out by

the U.G./ P.G students of chemical engineering, under guidance of the staff.

A. An M. Tech. Program in Biochemical Engg. has been approved in Febuary2002, by

the AICTE after an inspection visit of experts to the Dept. in Nov.2001

B. Expertise: The chemical engineering and chemistry faculty of this institution are well

qualified and competent, but complement of faculty is not adequate to run a full

fledged P G program.

Staff of Chemical Engineering:

Name and Designation of faculty Areas of Research

1. Dr. S. Sundaram Professor Process control,

Biotechnology

2. Dr.(Ms) S. K. Pandey Professor Heat transfer with

suspensions, Nucleate

Boiling

3. Dr. V. Venkata Ramani Professor Heat transfer with

phase change and

Instrumentation

4. Dr. H.J.Prabhu Asst. Professor Biochemical

engineering

5. Dr. P. Shanmugha Sundaram Asst. Professor Bio-process technology

6. Dr. N. Anantharaman Asst. Professor Fluidization,

Downstream processes

7. Dr. T. K. Radhakrishnan Asst. Professor Bio-process control,

Modeling

8. Dr. P. Siva Shanmugham Asst. Professor Bio-reaction

engineering, Equipment

Design

9. Dr. J. Sarat Chandra Babu Lecturer (senior) Modeling & Simulation

of bio-processes

10. Dr.(Ms) Meera S. Begam Lecturer Novel separation

techniques

11. Mr. M. Arivazhaghan Lecturer Environmental

biotechnology

12. Dr. (Ms).P. Kalaichelvi Lecturer Equipment design,

Process Engineering

Profile of the Department:

1 a) Name of the Institution REGIONAL ENGINEERING

COLLEGE, TIRUCHIRAPPPALLI

2 b) Name of the Department & year of

Establishment

CHEMICAL ENGINEERING: 1967

c) Address for correspondence Dr. S. Sundaram, Professor & Head,

Department of Chemical Eng.,

R. E.C., Tiruchirappalli – 620 015

Phone (0431) 500181 Ext 2901 (O)

(0431) 500295®

email: [email protected],in

3 Number of faculty members:

i) Professors; ii) Readers; iii)

Lecturers

Professors: 3

Asst. Professors: 5

Lecturers: 4

4 Distinction earned by faculty members

like National and International

Awards, Professional Societies.

Dr.T. K. Radhakrishnan

Young scientist fellowship awarded

&

Dr.(Mrs) S.K.Pandey awarded

Tamil Nadu Scientist Award both by

Tamil Nadu State Council for

Scientific Research

5 Student Strength at:

a) PG level – M. Tech. 48

b) Ph. D. in each sub-discipline

i) Plant Design

ii) Instrumentation and Control

iii) Energy Engineering

Two

Two

One

6 Indicate the development grant received from UGC/ AICTE

Seventh Plan Eight Plan

Building 14.0 lac

Equipment - -

7 Annual grant to the department from your Institution during last two years

Year For Research For Teaching

1998-99 - Rs. 20 000/-

1999-2000 - Rs. 20 000/-

8 Details of research grant from different agencies during the last five years:

MHRD – R & D 2000 8.0 lakhs

AICTE-modernization 1999 6.0 lakhs

AICTE-R&D 1997 5.0 lakhs



Research publications:

List of Research publications, including patents, coming out of your department during the last five years in the

refereed journals

1. Sundaram, S. (1995) “ Modeling and optimizing dextrose fermentation using a fluorosensor, vol.31,

page 251, 32nd

Annual MBS, Colorado.

2. Sundaram, S. (1996) “Modeling and optimizing citric acid production using a fluorosensor, 15th

Biomedical Engineering Conference, University of Dayton, OHIO, March 29-31 (1996)

3. Sundaram, S., Saileja, D., Kalpana, N. (1998) Modeling and optimizing alcohol production by

fermentation of dectrose-xylose mixed feed using a fluorosensor, vol. 34, 35th

Annual RMBS,

Colorado (1998)

4. Saravanan, V, Hemachandran, Eugene Raj and Sundaram, S (2000) Liquid Phase Volumetric Mass

Transfer Coefficient “ Bio Process Eng. Accepted for publication

5. Prabhu H.J. (1991) ‟Studies on effect of additives on bio-methanation ‟ in Research

and Industry, vol 36,March 1991

6. Prabhu H.J. (1991) „Studies on biomethanation of water hyacinth‟, in Research &

Industry, vol 36, June 1991.

7. P. Sivashanmugam and S. Sundaram (1998) “Hydrodynamics of Annular Circulating Fluidised Bed

Drier”, Powder Technology, July, 1999 p. 196-198

8. P. Sivashanmugam and S. Sundaram “Hydrodynamics of Annular Circulating Fluidised Bed Drier with

Sand particles” accepted for publication in the Journal of Bioprocess Engineering

9. P. Sivashanmugam and S. Sundaram “Residence Time Distribution studies in Annular Circulating

Fluidised Bed Drier” accepted for publication in Powder Technology

10. P. Sivashanmugam and S. Sundaram “Studies on Improvement in Performance of Heat Exchanger

fitted with Twisted Tape” ASCE Journal 1999, 92-96.

11. Sarat babu and B. Pitchumani (1997) “Performance studies on uniflow cyclone” paper presented at

Filtech International Conference, DECHEMA, organized at Disseldoff, Germany Sept. 14-16, 1997.

12. Ramanan, P, P. Srinivasa Rao, Sarat chandra babu,J, and Pitchumani, B (1997) “Effect of fine particles

on flow properties” Bulk Solids Handling, vol.4, 1997.

13. Karthik Narayanan and N. Anantharaman (1999) “ RED studies on Semi-fluidization” presented at

CHEMCON-99, held at Punjab University, Chandigarh, from 20 Dec. to 23 Dec. 1999.

14. Balasubramanian, N. and Anantharaman, N (1995) Fluidized bed drying of Granular materials”, paper

presented at the IIChE‟95, Annual Session at Kalpak am, India, 1995.

15. Sivashanmugam, P and Prabhu H.J. (1998) „Production of citric acid from

commercial sugar by Aspergillus niger‟ , presented in t CHEMCON,1998

16. Sivashanmugam, P and Prabhu H.J. (1999) „Production of citric acid using a mixed

culture of yeast and Aspergillus niger‟ , presented in CHEMCON 1999

17. Sivashanmugam, P and Prabhu H.J.(2000) „Production of Alpha Amylase „,

presented in CHEMCON 2000

18. Prabhu H.J. and Sivashanmugam. P.(2001) „Fluidized bed Biomethanation of

wastewater‟, presented at International Workshop on Environment and Energy,

Periyar Maniammai College of Technology for Women (PMCTW),

Periyarnagar,Nov 2001

Present Laboratory Facilities:

A biochemical engineering laboratory of about Rs. 80 lakhs is already established in the

department

The equipments available are

a. Braun make BIOSTAT-E laboratory fermenter with instrumentation

b. Fluidised bed fermenter -BIOENGINEERING make.

c. Anaerobic Chamber and BOD incubater

d. Freeze Drier and Deep Freezer

e. Laminar flow chamber

f. HPLC – Hitachi (Isocratic)

g. Gas chromatograph – Nucon

h. Porosimeter – Carlo Erba

i. Fluorosensor

j. UV-VIS spectrophotometer-JASCO

k. Orbital shaker

l. Centrifuges

Computer networking in the Institute:

Computer center has local area network (LAN) of 250 terminals at the center in addition to 4 terminals to

each department. CAD laboratory has three workstations loaded with UNIX based software packages.

Computing facilities in the Department:

Department has recently procured 6 stand alone systems out of AICTE Modernization / R&D projects.

Software packages are needed.

Fund required to upgrade existing facilities:

Rs.lakhs

New fluidized bed fermentors -Two 16.00

Coreco Image analyzer for cell counting 4.00

Accessories for Biochemistry analyzer 5.00

Accessories for Lyophilizer 1.00

Accessories for HPLC (Hitachi) 3.00

Upgradation of GC:

(New columns + standard gas samples

+ computer interfacing) 3.00

Accessories for Mercury porosimeter 2.00

Subscription to biotechnology

International journals 6.00

Extension Block

(50m x 20m = 1 000 sq. m.) 10.00

--------

Total ( Nonrecurring, In Rs. Lakhs) 50.00

--------

Staff and Other recurring fund Requirements: A) Teaching Staff:

Professor :One

Assistant Professor:One

Lecturer: One

B) Technical Staff: Trained Laboratory

assistants: Three

Particulars of Recurring

Amount (in lakhs of Rupees)

Salaries of faculty 6.36

Salaries of non-technical staff 1.28

Other recurring expenditure 1.60

Total Fund required:

Particulars Rs. lakhs

a) Recurring 9.74

b) Non-recurring

50.00

Grand Total 59.74

INFORMATI ON THE COURSE TO BE RECOGNISED / TO BE INTRODUCED

NAME OF THE DEPARTMENT: CHEMICAL ENGINEERING

1 Name of the course : M.Tech. Bio-chemical Engineering

Name of

the degree

Name of

specialisation.

Intake

(full time)

Year of

starting

Duration

(total)

Name of degree

& branch

eligible for

admission

M.Tech. Biochemical

Engineering

25 2002

2 years

( 4 semester)

4 years B.E.

/B.Tech or

equiv. degree

in Chemical/

Biochemical/

Electrochemical

Engineering

2 Course structure and scheme of evaluation (semester - wise)

Name of the subject Hours per week Credits Evaluation (Marks)

L T P Internal Written Practical Total

Semester – I

Microbiology

3 3 100

100

200

Biochemistry

3 3 100

100

200


3 4 100

100

200

Biochemical Reaction

Engineering

3 3 100

100

200

Microbiology &

Biochemistry Laboratory

9 3 100

100

200

Elective – 1

(See Annexure iv)

3 3 100

100

200


DETAILS ABOUT THE COURSE:

Name of the subject Hours per week Credits Evaluation (marks

L T P Internal Written Practical/

Viva

Tota

l

Semester - II

Bioprocess equipment

Design

3 3 100

100

200

Bioprocess Instrument. &

Control

3 3 100

100

200

Bioprocess Modeling and

Simulation

3 1 4 100

100

200

Bioprocess Laboratory 9 3 100

100

200

Elective - 2

3 3 100

100

200

Elective - 3

(See page 12)

3 3 100

100

200


Semesters III

Elective 4 3 3 100

100

200

Elective 5

3 3 100

100

200

Elective 6 3 3 100

100

200

Project Work

6 100


Semesters IV

Project Work

12 200 200

(Viva voce)

400


Total Credits in the Course = 65

M.Tech. (Bio-chemical Engineering)- SUMMARY OF SYLLABUS

M. Tech Specialization: Biochemical Engineering

SEMESTER 3 SEMESTER 4

Code

No

Title (Elective) Code

No

Title

MBCHE ** Elective Subject 4 MBCHE ** Elective Subject 5 MBCHE ** Elective Subject 6

PROJECT WORK PROJECT WORK

CODE

NO:

MBCH

M. Tech Specialization: Biochemical Engineering

TITLE OF ELECTIVE SUBJECTS

E 01 Separation & Analytical Techniques

E 02 Recombinant DNA Technology

E 03 Food Processing

E 04 Environmental Biotechnology

E 05 Plant Cell Culture

E 06 Advanced Downstream Processes

E 07 Pharmaceutical Technology

E 08 Animal Cell Technology

E 09 Enzyme Technology

M. Tech. Specialization: Biochemical Engineerng

SEMESTER 1 SEMESTER 2 Code No:

MBCH Title (core) Code No

MBCH Title (core)

101 Industrial Microbiology 201 Bioprocess Equipment

Design

102 Applied Biochemistry 202 Bioprocess Instrumentation

& Control

103 Bioprocess Engineering Principles 203 Modeling & Simulation of

Bioprocesses

104 Biochemical reaction Engineering 204 Bioprocess Lab

105 Microbiology & biochemistry Lab MBCHE** Elective Subject 2

MBCH

E**

Elective Subject 1 MBCHE ** Elective Subject 3

3. Method of admission to the course: GATE / Separate admission test

4. Facilities available in the Department for conducting the course

The department has a full fledged Bioprocess laboratory.

5. Supporting facilities available in the institution in the other departments:

Faculty from Chemistry, Instrumentation & Control Engineering, and Mathematics

Department are available for teaching the course.

6. Employment potential for those who will obtain the degree in the proposed course

The M. Tech. Biochemical Engineering degree envisaged will meet the demand for well

qualified young Biochemical Engineers to commercialize production of Biotech.

Products.

7. Additional Faculty and Other Staff Required if the Course is approved:

Professor Assistant

Professor

Lecturer Technical

Supporting

Staff

Non-technical

supporting

staff

1 1 1 3 -

8. Additional fund requirements for the course

Particulars

Amount (in lakhs of Rupees)

a) Recurring

1. Salaries of faculty 6.36

2. Salaries of non-technical staff 1.28

3. Salaries of supporting staff -

4. Scholarships -

5. Expenditure for travel -

6. Other recurring expenditure 1.60

Total 9.74

b) Non-recurring

1. Extension Block

50m x 20m = 1 000 sq. m.

10.00

2. Upgradation of

Laboratory Experimental

Facilities

40.00

3. Others Nil

Grand Total , Rs. Lakhs 59.74

9. Specify the funds required from AICTE/Ministry of HRD

a) Recurring

9.74 Rs. lakhs

b) Non-recurring 50.00 Rs. lakhs

Grand Total 59.74 Rs. lakhs

10. Details of Faculty already available for conducting the proposed courses.

11. Please mention the source of fund for the proposed course:

Fund required from the approved scheme of financial assistance for PG courses

(MHRD / AICTE/ DST (FIST- Level –1) and sponsored projects would be utilized.

12. Details of the UG courses (already being conducted in the department proposing the

course) which is relevant to the proposed course.

Name of the

degree

AICTE approval

no. and date

Intake Year of

starting

Duration

(Total)

Name of Degree/

Branch eligible

for admission

B.Tech. in

Chemical Engg.

F.2-15/B-111/RC-

MB/93

21-5-94

36 1967 4yrs N.A.

1. Signature of the Head of the Department

Name : Dr. S.Sundaram

2. Signature of the Head of the Institution

Name : Dr.

Name of the course No. of Professors No. of Asst.

Professors

No. of Lecturers Total

Ph.D. Ph.D. Ph.D. NonPh.D.

Biochemical Engineering 3 5 3 1 12

Annexure 2

Central Grants Utilized for Facilities

Name of project Sanction letter

No & date

year Amount

awarded /

spent Rs.Lakhs

IIT-REC(Biochemical

Engg.Laboratory)

F 4-1 / 87-T7

dt.2-3-88

1988 5

IIT-REC(Biochemical

Engg.Laboratory)

F 2-1/ 88-T7

dt.17-1-89

1989 5

Central Assistance,Thrust

Area(Biotechnology)

F1-2/88T7

Dt.17-1-89

1989 10

Central Assistance,Thrust

Area(Biotechnology)

F1-6/90-TD6

Dt. 25-1-91

1991 10

Details of research grant from different agencies during the

years 1993 to 2002:

Source Year Amount of Grant

MHRD – R & D 2000 8.0 lakhs

AICTE-modernization 1999 6.0 lakhs




ANNEXURE-3

Library Facilities Enhanced

I Back volumes of the journal, Bioengineering and Biotechnology (upto 1987) were added to the Central

library of the institution at a cost of about Rs. 29000/= during 1990-91. The following International

Journals in biotechnology were subscribed: a) Journal of Fermentation and Bioengineering b) Journal

of Biotechnology c) Biomass

II Reference Books made available during the last ten years:

1. Biotechnology, Volumes 1 to 8.Edited by H J Rehm and G. Reed, First Edition, Verlag Chemie, FRG

(1985-86)

2. Comprehensive Biotechnology, Volumes 1 to 4. Edited by Murray Moo Young, Pergamon Press

(1984-85)

3. Advances in Biochemical Engg. / Biotechnology, Volumes 22 to 32, Springer Verlag (Annual

Volumes)

4. Biotechnologies:Challemges and promises-Albert Sasson-UNESCO (1984)

5. Precott and Dunn‟s Industrial Microbiology (4th

Edition), Edited by G. Reed, Macmillan (1992)

6. Bio-reactor Immopbilised Enzymes and Cells: Fundamentals and Applications, Ed. By Murray Moo

Young, Elsevier Applied Sciences (1988)

7. A Revolution in biotechnology, Ed. By J. L. Marx, Cambridge University Press, Cambrdidge, (1989)

8. Handbook of Enzyme Biotechnology Ed. By A. Wiseman, Ellis Horwood, Chichester (1985)

9. Immobilized Cells and Enzymes: A Practical Approach, J. Woodward, IRL Press (1985)

10. Process Engineering Aspects of Immobilized Cell System. Institution of Chemical Engineers, U.K.,

(1986)

11. Microbiological Methods (5th

Edition) C.H. Collins and P. M. Lyne,

Butterworths, (1985)

12. Bioprocess Technology: Kinetics and Reactors A. Moser, Springer Verlag (1988)

13. Enzymes by Dixon and Web, (Third Edition) Academic Press(1979)

14. Fundamentals of Biotechnology, Edited by P. Prave, VCH, Weinheim (1987)

15. Bioreactors and Bio-transformations Ed. By G.W. Moody and P.B. Baker, Elsevier Applied Science

(1987)

NATIONAL INSTITUTE OF TECHNOLOGY,

TIRUCHIRAPPALLI, 620 015

DEPARTMENT OF CHEMICAL ENGINEERING

BIOCHEMICAL ENGINEERING

2004 - 2005

(JANUARY, 2004)

SUBMITTED TO

MINISTRY OF HUMAN RESOURCE DEVELOPMENT

DEPARTMENT OF EDUCATION

GOVERNMENT OF INDIA

NEW DELHI- 110 001

PROPOSAL FOR CONDUCTING

M.TECH. DEGREE COURSE IN

.

MODERNISATION AND REMOVAL OF OBSOLECENCE

1. Name and Full address with : NATONAL INSTITUTE OF

with pin code of the institution TECHNOLOGY

Tiruchirapalli-620015, Tamil Nadu

2. Title of Research Project : MODERNISATION AND REMOVAL OF

OBSOLESCENCE IN BIOCHEMICAL

ENGINEERING LABORATORY

3. Name of the Department : CHEMICAL ENGINEERING

4. (i) Name and Designation of

Principal Investigator : Dr.S.Sundaram

Professor and Head

(ii) (ii) Name and Designation of

Co- Investigator : Dr. H.J.Prabhu

Assistant Professor

(iii) Name and Designation of

Co- Investigator : Dr. P.Sivashanmugam

Assistant Professor

5. Total cost of the Project : 22.00lakhs

MODERNISATION AND REMOVAL OF OBSOLECENCE

1. Name and Full address with : NATONAL INSTITUTE OF

with pin code of the institution TECHNOLOGY

Tiruchirapalli-620015, Tamil Nadu

2. Title of Research Project : MODERNISATION AND REMOVAL OF

OBSOLESCENCE IN BIOCHEMICAL


3. Name of the Department : CHEMICAL ENGINEERING

4. (i) Name and Designation of

Principal Investigator : Dr.S.Sundaram

Professor and Head

(ii) (ii) Name and Designation of

Co- Investigator : Dr. H.J.Prabhu

Assistant Professor

(iii) Name and Designation of

Co- Investigator : Dr. P.Sivashanmugam

Assistant Professor

5. Total cost of the Project : 22.00lakhs

6. Details of Projects supported by the MHRD/AICTE during 1998/99 to 2002-03:

[Please See Annexure –1]

7. Summary of the Project:

a. Objectives of the Project:

To provide facilities for experimental courses and research projects in biochemical

engineering and biotechnology topics it is necessary to modernize the laboratory. To

include experimental courses along with the theory courses provided at present at

both the U.G, and P.G. levels, the additional facilities are needed. This will improve

our capacity to undertake consultancy projects also.

b. Methodology to be adopted to achieved these objectives:

A committee comprising of the Principle Coordinater and Co-coordinators, Head of

the Department, and the Dean, Planning and Development, will review the progress

once in six months.

c. Monitoring mechanism and self assessment:

An assessment of the utilization of the facility for the objectives proposed will

be made with feedback from the students and project investigators. Review will

indicate the progress of the project.

d. Stipulated Period of completion of the project: Two Years.

8. Introduction:

a. Present state of art:

The existing laboratory was established nearly a two decade back and was

used for carrying out experimental projects. Modern equipments and analysis

methods can enhance the utility of the facilities for regular lab course work as well

as for consultancy projects. Also, computer interfacing of the instrumented fermenter

for monitoring and control of parameters needs additional input.

b. Funding provided from other sources: Nil

c. Present level of infrastructure:

At present, a laboratory is available with a five liter capacity fermenter with

monitoring facilities. A laminar air flow chamber for inoculums handling,

laboratory autoclave, centrifuge, BOD incubator and muffle furnace are available.

An orbital shaker, a gas chromatograph and a spectrophotometer are available in

the laboratory.

9. Budget:

Name of the equipment Cost,

Rs. lakhs

1.Electrodes for dissolved oxygen and pH,

for fermented (autoclavable)

1.00

2.Laboratory sterilizer with control 3.00

3.Mini Jar Fermentor 5.00

4. Laboratory pH and ion analyzer with electrodes 3.00

5.Peristaltic pumps of varying capacity 1.00

6. Accessories for gas chromatograph 1.00

7. Glucose analyzer with Biosensor 5.00

8. Computer Networking facilities 3.00

Total 22.00

10. Summary sheet

1. Name of the Institution : NATIONAL INSTITUTE OF

TECHNOLGY

TIRUCHIRAPALLI-620015

2. Title of the project : MODERNISATION AND REMOVAL

OF OBSOLESCENCE IN BIOCHEMICAL


3. Name of the Department : CHEMICAL ENGIEERING

4. Cost of the Project : Rs 22lakhs

5. Amount Released Earlier : Nil

6. Utilization Position in respect of : Refer Annexure-I

grants released earlier

(up to 2000-2001)

for various projects

(Details to be given Project-wise)

7. Reason for unspent balance : Project period is not yet

Completed

8. Name of the Principal Investigator : Dr.S.Sundaram

9. Name of the Co-investigator : Dr.H.J.Prabhu and Dr.P.Sivashanmugam

FOR OFFICIAL USE ONLY

1. Name of the area :

2. Recommendations :

1) Approved

2) Not Approved

3) Deferred

4). Transferred to area Amount

(Rs. In lakhs)

3. Remarks if any

11. Certificate

Certified that

i) the Principal Investigator is not due to retirement during the currency

of the Project

ii) the Principal Investigator is regular employee of this institution.

However in case he/she proceeds on sabbatical/ resigns/proceeds on

VRS etc, the institute will ensure to replace PI by a compatible

academician to ensure that without any break whatsoever, project will

be completed within the stipulated period of 2 years.

iii) It will be ensured that the implementation will be carried out on

mission mode with no time or cost over run and we are aware that

ministry will neither provide any extension of time nor additional

funding

iv) No over heads will be charged by the institution for this project and all

facilitation including other essentials/infrastructure support like air-

conditioning etc will be provided by the institution

Seal of the Institution Signature of Head of Institution

Annexure-I

1.Non-linear

control of

Chemical reactors

Mr.T.K.Rathakrishnan

F.No.8017/RD

II/BOR/95/RCHE

6823/REC 90/DT 11-3-

1999

5.0 lakhs Completed

2.Modernization of

unit operation

laboratory

Dr.N.Anantharaman

Lr.No-F 23-10-1198 TS-1

dt 14-1-98(MODROBS)

6.0 lakhs Completed

3.Study of Gas-

Solid distributive

and dynamic flow

regimes in dense

flow pneumatic

Conveying

Dr.S.Sundaram F.26-

4/99,TS-1dt 13/3/2000

8.0 lakhs Project Time

Period is not yet

over

4. Modernisation

of Chemical

Reaction

Engineering

Laboratory

Dr.P.Sivashanmugam,F.28-

3(24)/2002-TS.V dt 19-03-

2002


Period is not yet

over

5. Heat Transfer

studies during

Nucleate Pool

boiling

Dr.Mrs.S.K.Pandey, F.26-

1/2000 T.SV,April-2001


Period is not yet

over

6. CFD Modeling

of Chemical

Process Equipment

Dr.Mrs.S.K.Pandey, F.27-

1/2002 T.SV,dt 19-03-2002


Period is not yet

over

6. Studies on

Emulsion Liquid

Membrane

Extraction

Dr.K.M.Meera Sheriffa

Begum, F.26-4/2002. TS.V

dt 31-032003


Period is not yet

over

7.

Project Title

Name of Co-ordinator

Project Cost

Project Status

Proposed d ch-e_ pg-BIOCHEMICAL ENGG

Education

Transcript of Proposed d ch-e_ pg-BIOCHEMICAL ENGG