programme wco-iof-esceo milan 2015

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PROGRAMME WCO-IOF-ESCEO MILAN 2015 WORLD CONGRESS ON OSTEOPOROSIS, OSTEOARTHRITIS AND MUSCULOSKELETAL DISEASES MARCH 26-29, 2015 | MILAN ITALY MiCo - Fiera Milano Congressi www.wco-iof-esceo.org Organized by Sinklar Conference Management B.V.

Transcript of programme wco-iof-esceo milan 2015

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PROGRAMME

WCO-IOF-ESCEOMILAN 2015

WORLD CONGRESS ON OSTEOPOROSIS,

OSTEOARTHRITIS AND MUSCULOSKELETAL DISEASES

MARCH 26-29, 2015 | MILAN ITALYMiCo - Fiera Milano Congressi

www.wco-iof-esceo.org

Organized by Sinklar Conference Management B.V.

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WCO-IOF-ESCEO MILAN 2015 1

EVENT World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases

DATES March 26-29, 2015

CONGRESS VENUE MiCo - Fiera Milano Congressi Via Gattamelata 5 - Gate 1420149 Milan, Italy www.micmilano.it

CONGRESS SECRETARIAT Yolande Piette CommunicationBd G. Kleyer, 108 | 4000 Liège - Belgium Tel: +32 (0)4 254 12 25 | Fax: +32 (0)4 254 12 90 E-mail: [email protected] www.piettecommunication.com

CONGRESS ORGANISER SINKLAR Conference Management B.V. Hogehilweg 5E, 1101CA Amsterdam Zuidoost - NetherlandsE-mail: [email protected]

CONGRESS WEBSITEwww.wco-iof-esceo.org

REGISTRATION

Early Registration < December 5, 2014IOF Member 735 € Non-Member 795 €Student 250 €

Pre-registration < December 5, 2014 - March 5, 2015 >IOF Member 795 € Non-Member 895 € Student 270 €

On SiteIOF Member 995 € Non-Member 995 € Student 300 €

DEADLINES

Registration cancellation: within June 30, 2014, 50% of the registration fee will be refunded. After this date, no refund will be possible for cancellations.

Submission of abstracts: January 15, 2015

Notification to the contributors: February 13, 2015

GENERAL INFORMATION

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WCO-IOF-ESCEO MILAN 20152

CONGRESS CHAIRMENJohn A. KANIS - IOF PresidentJean-Yves REGINSTER - ESCEO President

SCIENTIFIC COMMITTEECyrus COOPER Chair, IOF Committee Scientific Advisors (CSA)

René RIZZOLI Chair, ESCEO Scientific Advisory Board (SAB)

John A. KANIS IOF President

Jean-Yves REGINSTER ESCEO President

SCIENTIFIC ADVISORY BOARD Donato AGNUSDEI, Kristina AKESSON, Maurice AUDRAN, Jean-Jacques BODY, Mary BOUXSEIN, Maria Luisa BRANDI, Olivier BRUYERE, Nansa BURLET, Etienne CAVALIER, Claus CHRISTIANSEN, Juliet COMPSTON, Cyrus COOPER,Bernard CORTET, Jean-Pierre DEVOGELAER, Andrea GASPARIK, Nicholas HARVEY, Mickaël HILIGSMANN, John A. KANIS, Jean-Marc KAUFMAN, Paul LIPS, Roman LORENC, George LYRITIS, Johanne MARTEL-PELLETIER, Eugene McCLOSKEY, Socrates PAPAPOULOS, Karel PAVELKA, Jean-Pierre PELLETIER, Jean-Yves REGINSTER, Johann RINGE, René RIZZOLI, Christian ROUX, Pavel SZULC, Thierry THOMAS.

LOCAL ORGANIZING COMMITTEE Maria Luisa BRANDI (chair, LOC)

Emanuela BAIO DOSSI, Maria Luisa BIANCHI, Paolo CHERUBINO, Gaetano CREPALDI, Claudio CRICELLI, Maurizio CUTOLO, Andrea GENAZZANI, Giancarlo ISAIA, Andrea LENZI, Stefania MAGGI, Marco MATUCCI-CERINIC, Roberto MESSINA, Ranuccio NUTI, Sergio ORTOLANI.

SCIENTIFIC INFORMATION

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15.30-17.30Italian Session jointly organized by F.I.R.M.O. and E.S.C.E.O.Chairpersons: Maria‑Luisa Brandi, Bruno Rusticali - Introduction - Maria‑Luisa Brandi - AGENAS Guidelines on Osteoporosis: Methodology and Goals - Bruno Rusticali - The Reimbursement Policy for Osteoporosis Drugs in Italy - Ranuccio Nuti - Osteoporosis: The Challenges for the General Practitioner - Claudio Cricelli - Osteoarticular Disorders: The Multidimentional Approach of the “Società Italiana diOrtopedia e Traumatologia” (SIOT) - Maurizio Feola - The Contribution of the “Società Italiana di Reumatologia”(SIR) in the Fight againstOsteoarticular Disorders - Marco Matucci Cerinic - The Projects of the “Società Italiana dell’Osteoporosi e del Metabolismo Minerale edelle Malattie dello Scheletro” (SIOMMMS) in Osteoporosis - Giancarlo Isaia - Definition and Evaluation of Sarcopenia: The Italian Vision of the Geriatrician -Stefania Maggi - The Integrated Approach to Prevent refracture: The Fracture Unit Project of theOrtoMed Scientific Society - Luisella Cianferotti

17.30-18.30Best clinical papers published in 2014René Rizzoli

18.30-20.00WCO-IOF-ESCEO - OPENING CEREMONYChairpersons: John A. Kanis, Jean‑Yves Reginster

18.30-18.45Population ageing and health: the importance of policies totackle musculoskeletal diseasesIslene Araujo de Carvalho (World Health Organization – Geneva)

18.45-18.50Opening of the meetingJohn A. Kanis

18.50-19.50IOF-ESCEO-SERVIER HONORARY LECTURE - Historical genetics of wine grapes - José Vouillamoz

19.50-20.00Presentation of the ESCEO-IOF Servier Pierre D. Delmas PrizeJohn A. Kanis

20.00-21.00INDUSTRY-SPONSORED WELCOME COCKTAIL

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08.00-09.00NON-SPONSORED SYMPOSIA

Appl ication of Shape and Appearance Models inAppl ication of Shape and Appearance Models inOsteoporosis and OsteoarthritisOsteoporosis and OsteoarthritisChairperson: John Sheperd - Introduction to Statistical Appearance Modeling for Bone Applications- Tim Cootes - 3D to 2D and back again: registration and modeling of 3D bone from2D images for osteoporosis applications - Kenneth Poole - 3D Shape Characteristics of Arthritic Bone - Tuhina Neogi - 3D femur shape and appearance for fracture prediction - Is it ready forclinical applications? - Oleg Museyko

Targeting Osteosarcopenia: a practical approach for theTargeting Osteosarcopenia: a practical approach for theprevention of fal ls and osteoporotic fracturesprevention of fal ls and osteoporotic fracturesChairperson: Neil Binkley - Introduction - Neil Binkley - Pathophysiology of osteosarcopenia: Common mechanisms andpathways - Gustavo Duque - How to diagnose osteosarcopenia? - Bjoern Buering - Therapeutic interventions for osteosarcopenia - Christina Alonso

The personal and societal burden of Osteoarthritis:The personal and societal burden of Osteoarthritis:observations from EPOSAobservations from EPOSAChairperson: Elaine M. Dennison - Introduction - Elaine M. Dennison - Osteoarthritis and comorbidities as determinants of disability in olderpopulations - Stefania Maggi - Physical performance in later life and its relationship withOsteoarthritis - Mark H. Edwards - Frailty syndrome prevalence and slow walk speed in Osteoarthritis -Angel Otero - The neighbourhood environment and use of neighbourhood resources inolder people with and without Osteoarthritis - Erik Timmermans

NOF WORKSHOP

Calcium Supplementation: Does Protecting AgainstCalcium Supplementation: Does Protecting AgainstFracture Risk Increase the Risk of Cardio-vascular Diseases?Fracture Risk Increase the Risk of Cardio-vascular Diseases?Chairperson: Taylor C. Wallace - Calcium Supplementation and the Risk of Cardiovascular Events -Andrea Singer - The Role of Calcium Supplementation in Coronary Artery Disease: Whatis the Evidence? - Stephen Kopecky

Special Educational Lecture (supported by an unrestrictededucational grant from Shire)Chairperson: Serge Ferrari - Gaucher disease : The role of the bone specialist - Maria‑Luisa Brandi

08.30-09.00SPECIAL EDUCATIONAL LECTURE - Unexpected non bone effects of vitamin D - Maurizio Cutolo

09.00-10.20SCIENTIFIC SESSION IChairpersons: John A. Kanis, Jean‑Yves Reginster

09.00-09.30Plenary Lecture 1 - Osteoporosis and Sarcopenia: two disorders or one? - Roger Fielding

09.30-10.20Oral communications selected from abstracts

09.30-09.40OC1ODANACATIB ANTIFRACTURE EFFICACY AND SAFETY IN POSTMENOPAUSALWOMEN WITH OSTEOPOROSIS: RESULTS FROM THE PHASE III LONG-TERMODANACATIB FRACTURE TRIAL (LOFT)Presenting author: M. R. McClungAuthors: B. L. Langdahl, S. Papapoulos, K. G. Saag, S. Adami, H. G. Bone,T. De Villiers, D. P. Kiel, A. Kung, P. Kumar KM, S. K. Lim, X. Ling,K. Lippuner, C. Mautalen, T. Nakamura, J.‑Y. Reginster, I. R. Reid,J. A. Rodriguez Portales, C. Roux, J. Walliser, N. B. Watts, J. R. Zanchetta,C. A. F. Zerbini, A. Rybak‑Feiglin, D. Cohn, C. A. DaSilva, R. Massaad,A. C. Santora, B. B. Scott, K. D. Kaufman, N. Verbruggen, A. Leung,A. Lombardi

09.40-09.50OC2THE BMD RESPONSE TO BLOSOZUMAB IS INDEPENDENT OF INITIAL AGE,BODY MASS INDEX, AND BMD IN POSTMENOPAUSAL WOMEN WITH LOWBMD: RESULTS OF A PHASE 2 RANDOMIZED CLINICAL TRIALPresenting author: B. MitlakAuthors: A. Chiang, F. Marin, J. Krege, C. T. Benson

09.50-10.00OC3RESULTS OF 2 YEARS OF ROMOSOZUMAB TREATMENT FOLLOWED BY 1 YEAROF DENOSUMAB OR PLACEBO IN POSTMENOPAUSAL WOMEN WITH LOWBONE MINERAL DENSITYPresenting author: M. R. McClungAuthors: A. Chines, J. P. Brown , A. Diez‑Perez, H. Resch, J. Caminis,M. A. Bolognese, S. Goemaere, H. G. Bone, J. R. Zanchetta, J. Maddox,O. Rosen, S. Bray, A. Grauer

10.00-10.10OC4DENOSUMAB TREATMENT IN POSTMENOPAUSAL WOMEN WITHOSTEOPOROSIS FOR UP TO 9 YEARS: RESULTS THROUGH YEAR 6 OF THEFREEDOM EXTENSIONPresenting author: S. PapapoulosAuthors: C. Roux, H. G. Bone, P. Dakin, E. Czerwinski, D. Frey,D. L. Kendler, E. M. Lewiecki, J. Malouf, D. Mellström, J.‑Y. Reginster,H. Resch, N. S. Daizadeh, A. Wang, M. Gavin, R. B. Wagman, M. L. Brandi

10.10-10.20OC5THE POSITION OF STRONTIUM RANELATE IN TODAY'S MANAGEMENT OFOSTEOPOROSISPresenting author: J.‑Y. ReginsterAuthors: M. L. Brandi, J. Cannata Andia, C. Cooper, B. Cortet, J. M. Feron,H. K. Genant, S. Palacios, J. D. Ringe, R. Rizzoli

10.20-11.50SCIENTIFIC SESSION IIChairpersons: Cyrus Cooper, Jean‑Pierre Pelletier

10.20-10.50Plenary Lecture 2 - Management of Osteoporosis in Renal Failure -Marie‑Hélène Lafage‑Proust

10.50-11.00Presentation of the ESCEO-MSD FellowshipsBess Dawson‑Hughes

11.00-11.50Oral communications selected from abstracts

11.00-11.10OC6TRACKING OF 25-HYDROXYVITAMIN D STATUS DURING PREGNANCYPresenting author: R. J. MoonAuthors: S. R. Crozier, E. M. Dennison, S. M. Robinson, H. M. Inskip,K. M. Godfrey, C. Cooper, N. C. Harvey

11.10-11.20OC7EFFECTIVENESS OF MATERNAL VITAMIN D SUPPLEMENTATION: AMULTICENTRE RANDOMISED, DOUBLE-BLIND, PLACEBO CONTROLLED TRIAL(MAVIDOS)Presenting author: C. CooperAuthors: N. C. Harvey, M. K. Javaid, N. J. Bishop, S. Kennedy,A. T. Papageorghiou, R. Fraser, S. V. Gandhi, S. D'angelo, S. R. Crozier,R. J. Moon, N. K. Arden, E. M. Dennison, K. M. Godfrey, H. M. Inskip,I. Schoenmakers, A. Prentice, Z. Mughal, R. Eastell, D. M. Reid,The Mavidos Study Group

11.20-11.30OC8COST EFFECTIVENESS EVALUATION OF FRACTURE LIAISON SERVICES FOR THEMANAGEMENT OF OSTEOPOROSIS IN SWEDENPresenting author: E. JonssonAuthors: O. Ström, F. Borgström

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11.30-11.40OC9CLINICAL EFFECTIVENESS OF ORTHOGERIATRIC AND FRACTURE LIAISONSERVICE MODELS OF CARE FOR HIP FRACTURE PATIENTS: CONTROLLEDLONGITUDINAL STUDYPresenting author: S. HawleyAuthors: M. K. Javaid, D. Prieto‑Alhambra, N. K. Arden, J. Lippett,S. Sheard, C. Cooper, A. Judge

11.40-11.50OC10META-ANALYSIS OF OBSERVATIONAL STUDIES ON THE EFFECT OF INCRETINTREATMENT ON FRACTURE RISKPresenting author: J. H. M. DriessenAuthors: F. De Vries, P. Vestergaard, H. Van Onzenoort, J. Van Den Bergh,R. Henry, N. C. Harvey

12.15-13.45INDUSTRY-SPONSORED LUNCH SYMPOSIUMESCEO Algorithm for Osteoarthritis: from treatment guidelines to real lifeChairpersons: Maurizio Cutolo, Jean‑Yves Reginster - Biological and clinical effects of intra-articular hyaluronic acid: meta-analyses and real-life patient studies - Thierry Conrozier - Prevention and treatment of knee osteoarthritis with glucosaminesulfate: from clinical studies to real life. - Lucio C. Rovati - How can we help implementing ESCEO algorithm in real life -Jean‑Yves Reginster

INDUSTRY-SPONSORED LUNCH SYMPOSIUMCalcium and vitamin D – Fact and fictionChairperson: John A. Kanis - Welcome and introduction - John A. Kanis - Efficacy of calcium and vitamin D supplementation: Where are we now?- Cyrus Cooper - Calcium and vitamin D supplementation: Update on safety profile -René Rizzoli - Bone protective therapies with and without calcium and vitamin D –Does it matter? - Bess Dawson‑Hughes - Meeting summary and close - John A. Kanis

14.00-15.03Oral presentation of selected postersChairperson: Johanne Martel‑Pelletier

14.00-14.07P197TEN-YEAR RISKS OF FIRST OSTEOPOROTIC FRACTURES IN CHINESE WOMENAND MENPresenting author: L. SiAuthors: T. M. Winzenberg, A. J. Palmer

14.07-14.14P760PERSISTENCE LONG-TERM OF ALENDRONATE THERAPY ON OSTEOPOROTICPOPULATION IN TUSCANY REGIONPresenting author: G. MarcucciAuthors: L. Cianferotti, G. Gronchi, S. Parri, M. L. Brandi

14.14-14.21P268PERCENTAGE OF WOMEN ACHIEVING NON-OSTEOPOROTIC BMD T-SCORES ATTHE LUMBAR SPINE (LS) AND TOTAL HIP (TH) DURING UP TO 8 YEARS OFDENOSUMAB (DMAB) TREATMENTPresenting author: J. MaloufAuthors: C. Libanati, C. J. F. Lin, S. Adami, J. P. Brown , F. Cosman,E. Czerwinski, L. H. De Gregório, S. Ferrari, J.‑Y. Reginster, N. S. Daizadeh,A. Wang, R. B. Wagman, E. M. Lewiecki, S. Cummings

14.21-14.28P274FRAX PREDICTS INCIDENT FALLS IN ELDERLY WOMEN: FINDINGS FROMAUSTRALIAPresenting author: H. JohanssonAuthors: N. C. Harvey, A. Odén, E. V. McCloskey, J. A. Kanis, G. Nicholson,K. M. Sanders

14.28-14.35P638GREATER ACCESS TO FAST FOOD OUTLETS IS ASSOCIATED WITH POORERBONE HEALTH IN YOUNG CHILDRENPresenting author: C. VogelAuthors: C. Parsons, K. M. Godfrey, S. M. Robinson, N. C. Harvey,H. M. Inskip, C. Cooper, J. Baird

14.35-14.42P485PROLONGED HYPOVITAMINOSIS D IN ELDERLY WOMEN IS ASSOCIATEDWITH LONG AND SHORT TERM MORTALITY: RESULTS FROM THE OPRACOHORTPresenting author: D. BuchebnerAuthors: F. E. Mcguigan, P. Gerdhem, M. Ridderstråle, K. Akesson

14.42-14.49P753COST-EFFECTIVENESS OF DAIRY PRODUCTS SUPPLEMENTED WITH VITAMIN DIN THE PREVENTION OF OSTEOPOROTIC FRACTURESPresenting author: O. EthgenAuthors: M. Hiligsmann, O. Bruyère, J.‑Y. Reginster

14.49-14.56P279QOL IMPROVEMENT OF OSTEOPOROTIC PATIENTS TREATED WITHALENDRONATE ALONE OR ALENDRONATE PLUS ALFACALCIDOL THERAPY:RESULTS OF THE JAPANESE OSTEOPOROSIS INTERVENTION TRIAL (JOINT) -02Presenting author: H. OrimoAuthors: H. Ohta, M. Shiraki, T. Nakamura

14.56-15.03P763SELF-RATED HEALTH PREDICTS HIP FRACTURES INDEPENDENT OF FRAXPresenting author: H. Lundin

14.00-15.00Poster Viewing Session I (P101-P400)

EDUCATIONAL LECTURE 1 - How to apply for a job in a pharmaceutical company - Lucio C. Rovati

ESCEO SYMPOSIA

Revision of the guidel ines for the registration of drugsRevision of the guidel ines for the registration of drugsto be used in the treatment of Osteoarthritisto be used in the treatment of OsteoarthritisChairpersons: Andrea Laslop, Susanne Reiter‑Niesert - Welcome and introduction - Andrea Laslop - Current regulatory requirements for registration of drugs to be used inosteoarthritis in Europe and need for clarification - Jean‑Yves Reginster - Suggested clarification by the ESCEO working group - Francis Berenbaum - Discussion - Leader: Stefania Maggi - Conclusions and wrap-up - Andrea LaslopPanel: Eric Abadie, Francis Berenbaum, Jaime Branco, Maria‑Luisa Brandi,Olivier Bruyère, Cyrus Cooper, Jean‑Pierre Devogelaer,Gabriel Herrero‑Beaumont, John A. Kanis, Andrea Laslop, Stefania Maggi,Jean‑Yves Reginster, Susanne Reiter‑Niesert, René Rizzoli,Jean‑Marie Robine

Improving Osteoporosis Care with Trabecular BoneImproving Osteoporosis Care with Trabecular BoneStructure (TBS)Structure (TBS)Chairpersons: David L. Kendler, Claus C. Glüer - Welcome and introduction - Claus C. Glüer - TBS in fracture risk assessment - Nicholas Harvey - Other potential applications of TBS - Neil Binkley - Discussion leaders - Claus Glüer - John A. Kanis - Conclusions - John A. KanisPanel: Neil Binkley, Maria‑Luisa Brandi, Bruno Muzzi Camargos,Cyrus Cooper, Claus C. Glüer, John A. Kanis, David L. Kendler, Olivier Lamy,Andrea Laslop, Jean‑Yves Reginster, René Rizzoli

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14.00-15.00MEET-THE-EXPERT SESSIONS

Sequential/combined therapies in OsteoporosisSequential/combined therapies in OsteoporosisSerge Ferrari

Management of pain in OsteoporosisManagement of pain in OsteoporosisMaria‑Luisa Brandi

Exercise, nutrition, bone and musclesExercise, nutrition, bone and musclesBess Dawson‑Hughes

Epidemiology and management of post-menopausalEpidemiology and management of post-menopausalOsteoporosis in Latin AmericaOsteoporosis in Latin AmericaPatricia Clark

Genetic markers for the prediction of fragil ity fracturesGenetic markers for the prediction of fragil ity fracturesFernando Rivadeneira

Role of nutriceuticals in the management ofRole of nutriceuticals in the management ofOsteoarthritisOsteoarthritisGabriel Herrero‑Beaumont

Imaging of osteoarthritis in daily practiceImaging of osteoarthritis in daily practicePhilip Conaghan

15.00-16.40SCIENTIFIC SESSION IIIChairpersons: René Rizzoli, Olivier Bruyère

15.00-15.30Plenary Lecture 3 - Bone anabolic therapies for Osteoporosis - Socrates Papapoulos

15.30-15.40Presentation of the IOF President’s AwardsJohn A. Kanis

15.40-16.40Oral communications selected from abstracts

15.40-15.50OC11WANING LONG-TERM PREDICTIVE VALUE OF FALLS HISTORY FOR INCIDENTFRACTURE: MROS SWEDENPresenting author: H. JohanssonAuthors: N. C. Harvey, A. Odén, M. K. Karlsson, B. Rosengren, C. Cooper,O. Ljunggren, E. V. McCloskey, J. A. Kanis, C. Ohlsson, D. Mellström

15.50-16.00OC12PAINFUL KNEE BUT NOT HAND OSTEOARTHRITIS PREDICTS EXCESSMORTALITY IN A COMMUNITY-BASED COHORT OF MIDDLE-AGED WOMENWITH 23 YEARS OF FOLLOW-UPPresenting author: S. KluzekAuthors: M. T. Sanchez‑Santos, K. M. Leyland, A. Judge, C. Cooper,J. Newton, N. K. Arden, T. D. Spector, D. Hart

16.00-16.10OC13DIACEREIN REDUCES ANTAGONISTS OF WNT ENABLING THIS SYSTEM'SACTIVITY IN HUMAN OSTEOARTHRITIC SUBCHONDRAL BONE OSTEOBLASTSPresenting author: J. Martel‑PelletierAuthors: F. Mineau, D. Hum, J.‑P. Pelletier

16.10-16.20OC14ASSESSMENT AND DETERMINANTS OF AESTHETIC DISCOMFORT IN HANDOSTEOARTHRITIS: THE LIÈGE HAND OSTEOARTHRITIS COHORT (LIHOC)Presenting author: A. NeuprezAuthors: O. Bruyère, N. Dardenne, S. Distèche, E. Maheu, N. Burlet,J.‑Y. Reginster

16.20-16.30OC15PREDICTORS OF POST-OPERATIVE MORTALITY FOLLOWING TOTAL HIPARTHROPLASTY SURGERY: A POPULATION-BASED COHORT STUDYPresenting author: D. Prieto‑AlhambraAuthors: C. Tebé, F. Pallisó, A. Judge, N. K. Arden, C. Cooper,M. Espallargues

16.30-16.40OC16BIOMARKERS OF OSTEOCHONDRAL BONE FORMATION ARE INCREASED INPSORIASIS ARTHRITIS AND SPONDYLOARTHRITISPresenting author: A. S. Denmark - BAY-JENSEN A.C. (id=548) - A. C. Bay‑Jensen - N. S. Gudmann - H. L. Munk - A. F. Christiansen - L. Ejstrup - G. L. Sorensen - A. G. Loft - C. Christiansen - A. S. Siebuhr - P. Junker - M. K. Karsdal

17.00-18.30INDUSTRY-SPONSORED SATELLITE SYMPOSIUMEvolving Strategies for Management of OsteoporosisChairperson: Silvano Adami - Opening Remarks - Silvano Adami - The Role of Cathepsin K in Bone Homeostasis - Ego Seeman - Odanacatib Antifracture Efficacy in Postmenopausal Women; ResultsFrom the Phase 3 Long-term Odanacatib Fracture Trial (LOFT) -Michael R. McClung - Safety and Tolerability of Odanacatib in Post-Menopausal Women;Interim Results From the Phase 3 Long-term Odanacatib Fracture Trial(LOFT) - Socrates Papapoulos - Closing - Panel Question and Answer - Silvano Adami

INDUSTRY-SPONSORED SATELLITE SYMPOSIUMManagement of severe osteoporosis: personnalized medicine in practiceChairpersons: Maria‑Luisa Brandi, Jean‑Yves Reginster - Introduction - Maria‑Luisa Brandi - Why is severe Osteoporosis still an unmet medical need 40 years afterthe discovery of the first drugs? - Maria‑Luisa Brandi - Management of patients contra-indicated or not tolerant to anti-resorptive treatments - René Rizzoli - New indication and safety of strontium ranelate: a comprehensivereview - Cyrus Cooper - Conclusion - Jean‑Yves Reginster

18.45-19.45Cocktail offered by IOF and ESCEO to all recipients of prizes, awards,fellowships and scholarships - by invitation only

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08.00-09.00IOF WORKSHOPS

Bone and Diabetes: Diabetes and Skeletal chal lengesBone and Diabetes: Diabetes and Skeletal chal lengesChairpersons: Cyrus Cooper, Massimo Massi Benedetti - Epidemiology of Diabetes and Osteoporosis - Bo Abrahamsen - Pathophysiology of Diabetoporosis - Serge Ferrari - New Diabetes Treatments and Bone - Nicola Napoli

IMS-IOF Joint Session: MHT: Menopausal HormoneIMS-IOF Joint Session: MHT: Menopausal HormoneTherapy revisitedTherapy revisitedChairperson: Bess Dawson‑Hughes - Menopause: consequences and overall management - John C. Stevenson - MHT: risks and benefits from the IMS perspective - Tobie De Villiers - SERM/HRT combinations - Peyman Hadji

NON-SPONSORED SYMPOSIA

Hands-on on DXA acquisition and analysis: artifactualHands-on on DXA acquisition and analysis: artifactualpitfal ls and possible escapespitfal ls and possible escapesChairpersons: Bruno Muzzi Camargos, Ben‑Hur Albergaria - Dual X-Ray Absorptiometry Basic Principles - Bruno Muzzi Camargos - Clinical Cases. Lumbar Spine, Femur - Bruno Muzzi Camargos - Monitoring DXA - Bruno Muzzi Camargos

The nutritional approach to weight management andThe nutritional approach to weight management andmusculoskeletal healthmusculoskeletal healthChairpersons: René Rizzoli, Jean‑Jacques Body - The benefits of yogurt to manage weight and metabolic diseases -Arne Astrup - Dairies and sustainable musculoskeletal health - René Rizzoli

09.00-10.20SCIENTIFIC SESSION IVChairpersons: Maria‑Luisa Brandi, Stefania Maggi

09.00-09.30Plenary Lecture 4 - Can we alter the natural history of Osteoarthritis? - Marc Hochberg

09.30-09.40Presentation of the IOF Medal of AchievementCyrus Cooper

09.40-10.20Oral communications selected from abstracts

09.40-09.50OC17BONE MICROARCHITECTURE ASSESSED BY HR-PQCT PREDICTS INCIDENTFRAGILITY FRACTURE IN POSTMENOPAUSAL WOMEN: THE OFELY STUDYPresenting author: E. Sornay‑RenduAuthors: S. Boutroy, F. Duboeuf, R. D. Chapurlat

09.50-10.00OC18A META-ANALYSIS OF TRABECULAR BONE SCORE IN FRACTURE RISKPREDICTION AND ITS INTERACTION WITH FRAXPresenting author: J. A. KanisAuthors: A. Odén, N. C. Harvey, W. D. Leslie, D. Hans, H. Johansson,R. Barkmann, S. Boutroy, J. P. Brown , R. D. Chapurlat, P. Elders,Y. Fujita, C. C. Glüer, D. Goltzman, M. Iki, M. K. Karlsson, A. Kindmark,N. Kurumatani, A. Kwok, J. Leung, K. Lippuner, O. Ljunggren,M. Lorentzon, D. Mellström, T. Merlijn, L. Oei, C. Ohlsson, J. A. Pasco,F. Rivadeneira, B. Rosengren, E. Sornay‑Rendu, P. Szulc, J. Tamaki,E. V. McCloskey

10.00-10.10OC19IN VIVO CORTICAL BONE INDENTATION MEASUREMENTS ARE INDEPENDENTOF AGE, BMD AND CORTICAL MORPHOLOGY IN POSTMENOPAUSAL WOMENPresenting author: J. N. TsaiAuthors: E. W. Yu, N. Derrico, A. Martinez‑Betancourt, M. L. Bouxsein

10.10-10.20OC20SENSITIVITY AND SPECIFICITY OF RADIOGRAPHIC CHARACTERISTICS OFATYPICAL FEMORAL FRACTURESPresenting author: J. Q. ChantraAuthors: A. L. Adams, F. Xue, R. M. Dell, S. M. Ott, S. Silverman,J. C. Giaconi, C. W. Critchlow

10.20-11.40SCIENTIFIC SESSION VChairpersons: Jean‑Marc Kaufman, Socrates Papapoulos

10.20-10.50Plenary Lecture 5 - Is it time to resurrect menopausal hormone therapy in Osteoporosis? -John C. Stevenson

10.50-11.40Oral communications selected from abstracts

10.50-11.00OC21COMPARATIVE PERFORMANCE OF CURRENT DEFINITIONS OF SARCOPENIAAGAINST THE PROSPECTIVE INCIDENCE OF FALLS AMONG COMMUNITY-DWELLING SENIORS AGE 65 AND OLDERPresenting author: B. Dawson‑HughesAuthors: E. J. Orav, J. A. Kanis, R. Rizzoli, M. Schlögl, H. B. Staehelin,W. C. Willett, H. A. Bischoff‑Ferrari11.00-11.10OC22PHASE 2 RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROLLED TRIAL OFMYOSTATIN ANTIBODY IN OLDER FALLERS WITH LOW MUSCLE STRENGTHPresenting author: S. FerrariAuthors: C. Becker, S. R. Lord, S. Studenski, S. J. Warden, R. Fielding,C. Recknor, M. C. Hochberg, H. Blain, E. F. Binder, Y. Rolland,S. Poiraudeau, C. T. Benson, S. L. Myers, L. Hu, Q. Ahmad, K. Pacuch,E. Gomez, O. Benichou

11.10-11.20OC23CORRELATION BETWEEN MUSCLE MASS AND MUSCLE STRENGTH AND THEIRASSOCIATION WITH PHYSICAL PERFORMANCE AND GAIT SPEEDPresenting author: C. BeaudartAuthors: J.‑Y. Reginster, J. L. Croisier, J. Slomian, F. Buckinx, M. Locquet,A. Quabron, O. Bruyère

11.20-11.30OC24EFFECT OF AGE AND SEX ON JUMPING MECHANOGRAPHY AND OTHERMEASURES OF MUSCLE MASS AND FUNCTIONPresenting author: B. BueringAuthors: E. Fidler, D. Krueger, R. E. Ward, P. Caserotti, E. S. Strotmeyer,T. B. Harris, N. Binkley

11.30-11.40OC25CRITICAL EVALUATION OF PROMISING MARKERS FOR SARCOPENIAPresenting author: E. CavalierAuthors: R. Gadisseur, S. Geboes, A.‑C. Bekaert, A. Carlisi, O. Bruyère,J.‑Y. Reginster

12.15-13.45INDUSTRY-SPONSORED LUNCH SYMPOSIUMDairy products & bone health: turning facts and beliefs into clinicalpracticeChairpersons: Jean‑Yves Reginster, René Rizzoli - The acid-ash hypothesis and bone health - Tanis Fenton - Dairy consumption, prevention of osteoporosis & fractures: an update -Olivier Bruyère - Dairy product facts & fiction - Jean‑Jacques Body

INDUSTRY-SPONSORED LUNCH SYMPOSIUMPutting the Patient First: Effective Therapeutic Strategies to Reduce theBurden of FracturesChairperson: Maria‑Luisa Brandi - Welcome & Introduction - Maria‑Luisa Brandi - Bridging the Osteoporosis Care Gap: Improving Patient Outcomes with aFracture Liaison Service - Maria‑Luisa Brandi - Understanding the Fragile Patient: Identifying and Addressing theClinical Challenge - Astrid Fahrleitner‑Pammer - Preventing Secondary Osteoporosis: Anabolic vs Anti-resorptive Therapyfor Improving Patient Outcomes - Erik Fink Eriksen - Question & Answer. Symposium Close - Maria‑Luisa Brandi

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14.00-15.03Oral presentation of selected postersChairperson: Johanne Martel‑Pelletier

14.00-14.07P288ALENDRONATE IMPROVES BONE MATERIAL LEVEL PROPERTIES IN PAIREDHUMAN TRANSILIAC BONE BIOPSY SPECIMENSPresenting author: P. AmmannAuthor: R. Rizzoli

14.07-14.14P199CLUSTER ANALYSIS OF HIGH RESOLUTION PERIPHERAL QUANTITATIVECOMPUTED TOMOGRAPHY PARAMETERS IDENTIFIES BONE PHENOTYPESASSOCIATED WITH HIGH RATES OF PREVALENT FRACTUREPresenting author: M. H. EdwardsAuthors: D.E. Robinson, C. Parsons, K. A. Ward, E. M. Dennison, C. Cooper

14.14-14.21P241THE EFFECT OF LOCAL ANAESTHETIC INFILTRATION ON CHRONIC POST-SURGICAL PAIN AFTER TOTAL HIP AND KNEE REPLACEMENT: THE APEXRANDOMISED CONTROLLED TRIALSPresenting author: R. Gooberman‑HillAuthors: V. Wylde, E. Lenguerrand, E. Marques, S. Noble, J. Horwood,M. Pyke, P. D. Dieppe, A. W. Blom

14.21-14.28P265GRIP FATIGUE RESISTANCE AND SELF-PERCEIVED FATIGUE IN RELATIONWITH SARCOPENIA AND QUALITY OF LIFEPresenting author: C. BeaudartAuthors: J.‑Y. Reginster, I. Bautmans, J. L. Croisier, J. Slomian,F. Buckinx, M. Locquet, A. Quabron, O. Bruyère

14.28-14.35P642SCLEROSTIN ANTIBODY IMPROVES VERTEBRAE PARAMETERS IN MURINEMODEL OF SEVERE OSTEOGENESIS IMPERFECTAPresenting author: M. CardinalAuthors: J.‑P. Devogelaer, A. Dessain, D. Chappard, S. Lafont, T. Roels,M. S. Ominsky, B. Lengelé, C. Nyssen‑Behets, D.H. Manicourt

14.35-14.42P669SUBCHONDRAL TIBIAL BONE TEXTURE ANALYSIS PREDICTS KNEEOSTEOARTHRITIS PROGRESSION: DATA FROM THE OSTEOARTHRITISINITIATIVEPresenting author: T. JanvierAuthors: H. Toumi, A. Valery, L. Delsol, R. Jennane, E. Lespessailles

14.42-14.49P133TRABECULAR BONE SCORE IN PATIENTS WITH CHRONIC GLUCOCORTICOIDOSTEOPOROSIS TREATED WITH ALENDRONATE OR TERIPARATIDEPresenting author: K. G. SaagAuthors: D. Agnusdei, D. Hans, L. A. Kohlmeier, K. D. Krohn, E. S. Leib,E. J. Maclaughlin, K. See, C. Simonelli, K. A. Taylor, R. Marcus

14.49-14.56P551RADIOGRAPHIC OSTEOARTHRITIS IS LESS STRONGLY ASSOCIATED WITHPHYSICAL PERFORMANCE THAN CLINICAL OSTEOARTHRITIS IN OLDERINDIVIDUALSPresenting author: E. M. DennisonAuthors: M. H. Edwards, C. Parsons, A. E. Litwic, C. Cooper, A. Aihie Sayer

14.56-15.03P447DROPPING THE BALL AND FALLING OFF OF THE TREATMENT WAGON:FACTORS CORRELATING WITH NONCOMPLIANCE TO SECONDARY FRACTUREPREVENTION PROGRAMS - EXPERIENCE WITH THE OSTEOPOROSIS PATIENTTARGETED AND INTEGRATED MANAGEMENT FOR ACTIVE LIVING (OPTIMAL)PROGRAM IN SINGAPOREPresenting author: M. ChandranAuthors: X. F. Huang, M. Tan

14.00-15.00Poster Viewing Session II (P401-P800)

INDUSTRY-SPONSORED SATELLITE SYMPOSIUMOld and new treatments for bone diseasesChairperson: Socrates Papapoulos - Vitamin D: Its expanding role in the maintenance of bone health -Maria‑Luisa Brandi - New trends in the treatment of algodystrophy - Silvano Adami - Adherence to treatment in osteoporosis: challenges and new scenarios -Nicola Napoli

EDUCATIONAL LECTURE 2 - How to write a grant? - Ego Seeman

ESCEO SYMPOSIUM

European perspective of the new guidel ines for theEuropean perspective of the new guidel ines for themanagement of Osteoarthritis – focus on SYSADOAsmanagement of Osteoarthritis – focus on SYSADOAsChairpersons: Jean‑Pierre Devogelaer, Gabriel Herrero‑Beaumont - Introduction and scope of the problem - Marc Hochberg - Glucosamine and chondroitin salts in the management of osteoarthritisin Europe - Jean‑Yves Reginster - Hyaluronic acid salts in the management of Osteoarthritis in Europe -Jean‑Pierre Pelletier - Discussion - Leader: Jaime BrancoPanel: Eric Abadie, Jaime Branco, Maria‑Luisa Brandi, Olivier Bruyère,Cyrus Cooper, Jean‑Pierre Devogelaer, Gabriel Herrero‑Beaumont,Marc Hochberg, John A. Kanis, Emmanuel Maheu, Jean‑Pierre Pelletier,Jean‑Yves Reginster, René Rizzoli

MEET-THE-EXPERT SESSIONS

Diagnosis and treatment of sarcopeniaDiagnosis and treatment of sarcopeniaMarjolein Visser

Physical rehabil itation in Musculoskeletal conditions:Physical rehabil itation in Musculoskeletal conditions:which method?which method?Olivier Bruyère

Use of FRAX worldwide: current chal lenges andUse of FRAX worldwide: current chal lenges andsolutionssolutionsJohn A. Kanis

Epidemiology and management of post-menopausalEpidemiology and management of post-menopausalOsteoporosis in the Middle East and AfricaOsteoporosis in the Middle East and AfricaLeith Zakraoui

Monitoring of Osteoporosis treatmentsMonitoring of Osteoporosis treatmentsJonathan D. Adachi

Management of difficult cases in osteoporosisManagement of difficult cases in osteoporosisCyrus Cooper

15.00-16.40SCIENTIFIC SESSION VIChairpersons: Johanne Martel‑Pelletier, Marc Hochberg

15.00-15.30Plenary Lecture 6 - How long should we treat osteoporotic patients? - Maria‑Luisa Brandi

15.30-16.40Oral communications selected from abstracts

15.30-15.40OC26PROFESSIONAL ACTIVITY-DEPENDENT REPEATED LOADING INFLUENCESCORTICAL BONE GEOMETRY AND STRENGTHPresenting author: E. BiverAuthors: G. Perréard Lopreno, M. Hars, S. Ferrari, M. Besse, R. Rizzoli

15.40-15.50OC27HIP AXIS LENGTH IS A FRAX AND BONE DENSITY INDEPENDENT RISKFACTOR FOR HIP FRACTURE IN MEN AND WOMENPresenting author: W. D. LeslieAuthors: L. M. Lix, S. N. Morin, H. Johansson, A. Odén, E. V. McCloskey,J. A. Kanis

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15.50-16.00OC28THE EFFECT OF GLUCOSE-LOAD ON BONE REMODELING MARKERS ANDOSTEOBLAST FUNCTIONPresenting author: I. LevingerAuthors: G. Jerums, G. McConell, M. Rybchyn, S. Cassar, E. Byrnes,P. R. Ebeling, S. Selig, E. Seeman, T. Brennan‑Speranza

16.00-16.10OC29IMPAIRED TRABECULAR BONE MICROARCHITECTURE IMPROVES AFTER ONE-YEAR ON GLUTEN-FREE DIET: A PROSPECTIVE LONGITUDINAL HR-PQCTSTUDY IN WOMEN WITH CELIAC DISEASEPresenting author: M.B. ZanchettaAuthors: J. R. Zanchetta, C. Bogado, J. C. Bai, F. Silveira, R. M. Massure,F. Costa

16.10-16.20OC30COMBINING MEASUREMENT OF CORTICAL POROSITY AT THE PROXIMALFEMUR WITH FRAX IMPROVES THE SENSITIVITY AND MAINTAINS HIGHSPECIFICITY FOR FRACTUREPresenting author: M. OsimaAuthors: R. Joakimsen, R. M. Joakimsen, E. F. Eriksen , Å. Bjørnerem

16.20-16.30OC31WHAT TRIGGERS OSTEOPOROSIS THERAPY IN HIGH RISK RESIDENTSLIVING IN LONG TERM CARE (LTC) HOMES? THE GAINING OPTIMALOSTEOPOROSIS ASSESSMENTS IN LONG-TERM CARE (GOAL) STUDYPresenting author: G. IoannidisAuthors: D. O'donnell, C. Kennedy, H. Navare, L. M. Giangregorio,A. M. Cheung, S. Marr, R. G. Crilly, S. Feldman, R. Jain, S. Jamal,R. G. Josse, S. Prasad, L. Thabane, J. D. Adachi, A. Papaioannou

16.30-16.40OC32CONCORDANCE BETWEEN MUSCLE MASS ASSESSED BY BIOELECTRICALIMPEDANCE ANALYSIS AND BY DUAL ENERGY X-RAY ABSORPTIOMETRYAMONG ELDERLY PEOPLE: A CROSS-SECTIONAL STUDYPresenting author: F. BuckinxAuthors: J.‑Y. Reginster, N. Dardenne, J. L. Croisier, J. F. Kaux,C. Beaudart, J. Slomian, O. Bruyère

15.00-16.50COMMITTEE OF NATIONAL SOCIETIES SPECIAL PLENARY SESSIONHealthy Life, Healthy BonesChairpersons: Jean‑Yves Reginster, Judy Stenmark - Introduction - J. Stenmark

15.03-15.11OCs1HEALTHY LIFE, HEALTHY BONESPresenting author: M. TsagareliAuthors: E. Giorgadze, N. Dolidze, T. Sulikashvili, N. Jeiranashvili

15.11-15.19OCs2A POPULATION-BASED ANALYSIS OF THE POST-FRACTURE CARE GAP INHONG KONG: THE SITUATION IS NOT IMPROVINGPresenting author: A. W. H. HoAuthor: S. H. Wong

15.19-15.27OCs3"LET'S HOLD THE BONE TOGETHER": ORTHOPEDIC-METABOLICCOLLABORATIVE MANAGEMENT FOR OSTEOPOROTIC HIP FRACTUREPresenting author: P. Rotman‑PikielnyAuthors: M. Frankel, O. Tel‑Levanon, M. Tamar, E. Yakobi, D. Nabriski,D. Netzer, Y. Brin, M. Niska

15.27-15.35OCs4HANDGRIP STRENGTH PREDICTS ABILITY TO FUNCTION IN ACTIVITIES OFDAILY LIVING: A PROSPECTIVE STUDY OF 193 WOMEN WITH HIPFRACTUREPresenting author: M. Di MonacoAuthors: C. Castiglioni, E. De Toma, L. Gardin, S. Giordano, R. Tappero

15.35-15.43OCs5RECENT TREND IN THE INCIDENCE OF HIP FRACTURE IN TOTTORI, JAPANPresenting author: H. H. HaginoAuthors: Y. T. Tsukutani, M. O. Osaki, N.H. Nagashima

15.43-15.51OCs6ACCUMULATED ONE YEAR HEALTH UTILITY LOSS AFTER SUSTAINING A HIPFRACTURE IN MEXICOPresenting author: P. ClarkAuthors: L. Girant, F. Carlos, A. Svedbom, F. Borgström, J. A. Kanis

15.51-15.59OCs7RHEUMATOID CACHEXIA, OSTEOPOROSIS AND VERTEBRAL FRACTURESPresenting author: A. El MaghraouiAuthors: S. Sadni, A. Rezqi, A. Bezza, L. Achemlal, A. Mounach

15.59-16.07OCs8PSYCHOLOGICAL WELL BEING AND QUALITY OF LIFE ASSESSMENT OFWORKING WOMEN WITH OSTEOPOROSIS VERSUS RETIRED WOMEN WITHOSTEOPOROSISPresenting author: D. M. FarcasAuthors: F. Marc, C. Suteu, A. I. Gasparik, L. Sachelarie

16.07-16.15OCs9CAFFEINE, COFFEE AND TEA IN RELATION TO RISK OF HIP FRACTURE IN THESINGAPORE CHINESE HEALTH STUDYPresenting author: W. P. KohAuthor: Z. J. Dai

16.15-16.23OCs10EVALUATION OF BONE HEALTH OF MALE WORKERS IN A RECYCLINGFACTORYPresenting author: U. Akarirmak

16.23-16.31OCs11NATIONAL BONE HEALTH ALLIANCE: A MULTISECTOR PUBLIC-PRIVATEPARTNERSHIP WORKING TOGETHER TO IMPROVE AMERICA'S BONE HEALTHPresenting author: D. Lee

16.31-16.39OCs12OVERWEIGHT AND OBESITY AND RISK FRACTURE STUDY INPOSTMENOPAUSAL WOMEN FROM HAVANA AND MADRIDPresenting author: M. Diaz CurielAuthors: D. Navarro Despaigne, C. Prado Martinez

16.40-16.50Presentation of the IOF Committee of National Societies MedalJean‑Yves Reginster

17.00-18.00ESCEO-EUGMS SYMPOSIUM

Can we identify which patients should be treated inCan we identify which patients should be treated inOsteoarthritis?Osteoarthritis?Chairpersons: Johanne Martel‑Pelletier, Olivier Bruyère - Welcome and introduction - Olivier Bruyère - The need for phenotyping patients in Osteoarthritis - Marc Hochberg - Is it possible to phenotype patients in Osteoarthritis? - Nigel K. Arden - Discussion - Johanne Martel‑Pelletier - Wrap up and conclusions - Olivier BruyèrePanel: Eric Abadie, Nigel K. Arden, Francis Berenbaum, Jaime Branco,Maria‑Luisa Brandi, Olivier Bruyère, Philip Conaghan, Cyrus Cooper,Elaine M. Dennison, Jean‑Pierre Devogelaer, Gabriel Herrero‑Beaumont,Marc Hochberg, John A. Kanis, Stefania Maggi, Johanne Martel‑Pelletier,Jean‑Pierre Pelletier, Susanne Reiter‑Niesert, Jean‑Yves Reginster,René Rizzoli

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17.00-18.00IOF WORKSHOP

ISCD-IOF Joint Session: Latest trends on secondary fractureISCD-IOF Joint Session: Latest trends on secondary fracturepreventionpreventionChairpersons: Neil Binkley, Kristina Akesson - Capture the fracture ® -update - Cyrus Cooper - Novel diagnostic technologies - H.P. Dimai - Laboratory Work-up Post Hip Fracture Repair, What to Measure and When, theImpact of Surgery on Laboratory Results - Neil Binkley

17.00-18.30INDUSTRY-SPONSORED SATELLITE SYMPOSIUMHypophosphatasia: a rare disease with heterogeneous presentationChairpersons: Maria‑Luisa Bianchi, Maria‑Luisa Brandi - Opening Remarks - Maria‑Luisa Brandi - Introduction - Maria‑Luisa Bianchi - Characterizing the burden of disease in patients with HPP - Thomas Weber - Clinical presentation of HPP in a family with the same mutation: heterogeneous orhomogeneous phenotype? - Francesco Conti - Differentiating HPP from other musculoskeletal diseases - Christian Roux

INDUSTRY-SPONSORED SATELLITE SYMPOSIUMManaging Long-Term Osteoporosis: New InsightsChairpersons: Serge Ferrari, Ego Seeman - Welcome and introduction - Serge Ferrari - Efficacy and safety of long-term therapy with denosumab - Socrates Papapoulos - Target for osteoporosis therapy: Supportive evidence from the FREEDOM extension -Serge Ferrari - Explaining the differences in long-term BMD gains across therapies - Ego Seeman

18.00-20.00EUGMS ESCEO ESPEN IOF SYMPOSIUM-BY INVITATION ONLYIdentifying cohorts for sarcopenia study

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08.00-09.00NON-SPONSORED SYMPOSIA

Cl inical Appl ication of Bone MicroindentationCl inical Appl ication of Bone MicroindentationChairperson: Adolfo Diez‑Perez - Introduction to in vivo Microindentation - Mary L. Bouxsein - Microindentation in diabetes and stress fractures -Erik Fink Eriksen - Microindentation in patients with osteopenia and fractures and inOsteoporosis - Socrates Papapoulos

Osteogenic Loading, Low-Impact, High LoadingOsteogenic Loading, Low-Impact, High Loadingstimulus for Bone Density Developmentstimulus for Bone Density DevelopmentChairperson: John Jaquish - Introduction to impact forces, risks and rewards - Riku Nikander - Osteogenic loading and functional bone performance -John Jaquish - Neural inhibition and safety in static loading - Lynn Freeman

Links between atherosclerosis and osteoporosisLinks between atherosclerosis and osteoporosisChairpersons: Sekib Sokolovic, Roberto Jacomelli,Almira Hadzovic‑Dzuvo - Atherosclerosis: Degenerative or Inflammatory disease -Dragan Lovic - Osteoporosis: Degenerative or Inflammatory disease -Ülke Akarirmak - Atherosclerosis and Osteoporosis: Is there any link? -Sekib Sokolovic

Non-hol iday drug for osteoporosis. Non-hol iday drug for osteoporosis. Is it possibleIs it possibleto calculate the economic impact of anti fracture efficacyto calculate the economic impact of anti fracture efficacyversus side effect ?versus side effect ?Chairperson: Elio Tanaka - Introduction - Elio Tanaka - The drugs for osteoporosis , past , present and future -Fernanda Tanaka - The anti fracture efficacy and the adverse effects of theosteoporosis´drugs . - Claudia Totsugui Mariano - The economic impact of anti fracture efficacy versus side oradverse effects - Alexander Itria - The drug for bone event specialy in dismetabolic patients , likechronic kidney failure group of patients - Fabiana Gatti de Menezes - Questions and closing remarks - Elio Tanaka

09.00-11.10SCIENTIFIC SESSION VIIChairpersons: Roger Fielding, Nicholas Harvey

09.00-09.30Plenary Lecture 7 - Inflammation and bone fragility - Christian Roux

09.30-09.37Presentation of the IOF Olof Johnell Science AwardRené Rizzoli

09.37-09.40Presentation of the Yogurt in nutrition initiative2014 awardRené Rizzoli

09.40-10.40Oral communications selected from abstracts

09.40-09.50OC33SAFETY AND EFFICACY OF ODANACATIB IN THE TREATMENT OF MENWITH OSTEOPOROSIS: A RANDOMIZED PLACEBO-CONTROLLED TRIALPresenting author: R. D. ChapurlatAuthors: E. S. Orwoll, S. Adami, N. Binkley, B. L. Langdahl,S. Doleckyj, H. Giezek, B. B. Scott, A. C. Santora

09.50-10.00OC34FRAX-BASED ASSESSMENT AND INTERVENTION THRESHOLDS: AN EXPLORATIONOF THRESHOLDS IN WOMEN AGED 50 YEARS AND OLDER IN THE UKPresenting author: N. C. HarveyAuthors: J. A. Kanis, H. Johansson, A. Odén, A. Cooper, C. Cooper, R. M. Francis,D. M. Reid, P. Selby, J. E. Compston, E. V. McCloskey

10.00-10.10OC35REDUCED FRACTURE RISK IN DANISH WOMEN WITH POLYCYSTIC OVARYSYNDROME: A NATIONAL REGISTER-BASED COHORT STUDYPresenting author: B. AbrahamsenAuthors: D. Glintborg, M. Nybo, M. Andersen, K. H. Rubin

10.10-10.20OC36IMPACT OF HIP FRACTURE ON HOSPITAL CARE COSTS: A POPULATION BASEDSTUDYPresenting author: J. LealAuthors: A. M. Gray, M. K. Javaid, D. Prieto‑Alhambra, N. K. Arden, C. Cooper,A. Judge

10.20-10.30OC37A SYSTEMATIC REVIEW OF THE USE OF SPINAL ORTHOSES IN THE MANAGEMENTOF VERTEBRAL OSTEOPOROSIS AND OSTEOPOROTIC VERTEBRAL FRACTUREPresenting author: K. L. BarkerAuthors: C. Minns Lowe, M. Newman

10.30-10.40OC38EFFICACY STUDY OF THE TREATMENT OF OSTEOARTHRITIS-INDUCED KNEE PAINWITH AUTOLOGOUS CONDITIONED SERUM: A COMPARATIVE, PROSPECTIVE ANDRANDOMIZED STUDYPresenting author: D. W. Hang

10.40-11.10Plenary Lecture 8 - Guideline diversity in glucocorticoid-induced Osteoporosis - Cyrus Cooper

11.10-12.10ESCEO SYMPOSIUM

Guidel ines for the registration of drugs to be used inGuidel ines for the registration of drugs to be used infrail ty and sarcopeniafrail ty and sarcopeniaChairpersons: Alfonso Cruz Jentoft, Marjolein Visser - Introduction - René Rizzoli - Who should we treat in Sarcopenia - Antonio Cherubini - How to assess diseases in Sarcopenia - Roger Fielding - Discussion leader - Reginster Jean-Yves - René Rizzoli - Conclusion - Jean‑Yves ReginsterPanel: Islene Araujo de Carvalho (World Health Organization – Geneva),Heike A. Bischoff‑Ferrari, Maria‑Luisa Brandi, Olivier Bruyère, Etienne Cavalier,Antonio Cherubini, Cyrus Cooper, Gaetano Crepaldi, Alfonso Cruz Jentoft,Roger Fielding, Andrea Ildiko Gasparik, John A. Kanis, Alberto Pilotto,Jean‑Yves Reginster, Susanne Reiter‑Niesert, René Rizzoli, Serge Rozenberg

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18.50-19.50IOF-ESCEO-SERVIER HONORARY LECTURE - Historical genetics of wine grapes - José Vouillamoz

20.00-21.00MEDA AB WELCOME COCKTAIL

F r iday , Mar ch 27F r iday , Mar ch 27

12.15-13.45MEDA AB LUNCH SYMPOSIUMESCEO Algorithm for Osteoarthritis: from treatment guidelines to real lifeChairpersons: Maurizio Cutolo, Jean‑Yves Reginster - Biological and clinical effects of intra-articular hyaluronic acid: meta-analyses and real-life patient studies - Thierry Conrozier - Prevention and treatment of knee osteoarthritis with glucosaminesulfate: from clinical studies to real life. - Lucio C. Rovati - How can we help implementing ESCEO algorithm in real life -Jean‑Yves Reginster

TAKEDA LUNCH SYMPOSIUMCalcium and vitamin D – Fact and fictionChairperson: John A. Kanis - Welcome and introduction - John A. Kanis - Efficacy of calcium and vitamin D supplementation: Where are we now?- Cyrus Cooper - Calcium and vitamin D supplementation: Update on safety profile -René Rizzoli - Bone protective therapies with and without calcium and vitamin D –Does it matter? - Bess Dawson‑Hughes - Meeting summary and close - John A. Kanis

17.00-18.30MSD SATELLITE SYMPOSIUMEvolving Strategies for Management of OsteoporosisChairperson: Silvano Adami - Opening Remarks - Silvano Adami - The Role of Cathepsin K in Bone Homeostasis - Ego Seeman - Odanacatib Antifracture Efficacy in Postmenopausal Women; ResultsFrom the Phase 3 Long-term Odanacatib Fracture Trial (LOFT) -Michael R. McClung - Safety and Tolerability of Odanacatib in Post-Menopausal Women;Interim Results From the Phase 3 Long-term Odanacatib Fracture Trial(LOFT) - Socrates Papapoulos - Closing - Panel Question and Answer - Silvano Adami

SERVIER SATELLITE SYMPOSIUMManagement of severe osteoporosis: personnalized medicine in practiceChairpersons: Maria‑Luisa Brandi, Jean‑Yves Reginster - Introduction - Maria‑Luisa Brandi - Why is severe Osteoporosis still an unmet medical need 40 years afterthe discovery of the first drugs? - Maria‑Luisa Brandi - Management of patients contra-indicated or not tolerant to anti-resorptive treatments - René Rizzoli - New indication and safety of strontium ranelate: a comprehensivereview - Cyrus Cooper - Conclusion - Jean‑Yves Reginster

Satu r day , Mar ch 28Satu r day , Mar ch 28

12.15-13.45CERIN / CNIEL, EMF, GDP LUNCH SYMPOSIUMDairy products & bone health: turning facts and beliefs into clinicalpracticeChairpersons: Jean‑Yves Reginster, René Rizzoli - The acid-ash hypothesis and bone health - Tanis Fenton - Dairy consumption, prevention of osteoporosis & fractures: an update -Olivier Bruyère - Dairy product facts & fiction - Jean‑Jacques Body

ELI LILLY LUNCH SYMPOSIUMPutting the Patient First: Effective Therapeutic Strategies to Reduce theBurden of FracturesChairperson: Maria‑Luisa Brandi - Welcome & Introduction - Maria‑Luisa Brandi - Bridging the Osteoporosis Care Gap: Improving Patient Outcomes with aFracture Liaison Service - Maria‑Luisa Brandi - Understanding the Fragile Patient: Identifying and Addressing theClinical Challenge - Astrid Fahrleitner‑Pammer - Preventing Secondary Osteoporosis: Anabolic vs Anti-resorptive Therapyfor Improving Patient Outcomes - Erik Fink Eriksen - Question & Answer. Symposium Close - Maria‑Luisa Brandi

14.00-15.00ABIOGEN SATELLITE SYMPOSIUMOld and new treatments for bone diseasesChairperson: Socrates Papapoulos - Vitamin D: Its expanding role in the maintenance of bone health -Maria‑Luisa Brandi - New trends in the treatment of algodystrophy - Silvano Adami - Adherence to treatment in osteoporosis: challenges and new scenarios -Nicola Napoli

17.00-18.30AMGEN SATELLITE SYMPOSIUMManaging Long-Term Osteoporosis: New InsightsChairpersons: Serge Ferrari, Ego Seeman - Welcome and introduction - Serge Ferrari - Efficacy and safety of long-term therapy with denosumab -Socrates Papapoulos - Target for osteoporosis therapy: Supportive evidence from the FREEDOMextension - Serge Ferrari - Explaining the differences in long-term BMD gains across therapies -Ego Seeman

ALEXION SATELLITE SYMPOSIUMHypophosphatasia: a rare disease with heterogeneous presentationChairpersons: Maria‑Luisa Bianchi, Maria‑Luisa Brandi - Opening Remarks - Maria‑Luisa Brandi - Introduction - Maria‑Luisa Bianchi - Characterizing the burden of disease in patients with HPP -Thomas Weber - Clinical presentation of HPP in a family with the same mutation:heterogeneous or homogeneous phenotype? - Francesco Conti - Differentiating HPP from other musculoskeletal diseases - Christian Roux

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