Professor Avni Sali

MBBS PhD FRACS FACS FACNEM

Director - National Institute of Integrative Medicine,

Melbourne, Australia (www.niim.com.au)

President –International Council of Integrative Medicine

(www.icimedicine.com)

National Institute of

Integrative Medicine

Provides

• Education

• Research

• Clinical Service

National Institute of

Integrative Medicine

Clinical Services

• Integrative Medical Professionals

• Integrative Health Check

• World Class Cancer Treatment

Special Services

• Live Blood Analysis

• RTM Thermography

• Toxicology

• Circulating Tumour Cell Test

• Intravenous Therapies: Vitamin C & Chelation

• Hyperthermia

• Photo Dynamic Therapy

National Institute of

Integrative Medicine

Research

• Hyperthermia • Next GEN PDT

• PDT & Soundwave Therapy (Prostate & Bladder)

• Prostate Cancer (urine diagnosis)

• Cancer Cell Counting

• Mammoguard

• Heavy Metal Toxicity

• Children’s Wellness Integrative Program

• Other

National Institute of

Integrative Medicine

Mammoguard

National Institute of

Integrative Medicine

Education

Online Courses

• Short Course in Complementary/Integrative Med

Other Courses for accreditation

• Available during the year

Public Lectures

Other, e.g. Melbourne Review articles

National Institute of

Integrative Medicine

http://www.melbournereview.com.au/

Integrative Medicine

Definition

• Integrative Medicine combines the best conventional and evidence-based complementary medicine for an integrative approach to healthcare. The focus of integrative medicine is on optimal outcomes in terms of patient satisfaction and wellbeing, with an emphasis on the cause and treatment of illness as well as health creation.

Chronic Diseases

• Cancer-

Lung, Bowel, Breast, Prostate, Bladder

• Cardiovascular Disease

• Diabetes

• Brain problems

• Other

Principles of

Health /Healing/ Wellness

• Reduce Life Stresses

• Relaxation Techniques

• Daily Walk

• Healthy Food

• Supplements

© Avni Sali

Lifestyle and Health

Nurses Health Study:

78,000 women

Aged 34-59

Follow up – 24 years

Non-smoking, healthy diet and weight, moderate alcohol and exercise

• Four fold reduction in mortality

Van Dam R et al

BMJ 2008 online

Physical Activity

U.S. Guidelines

30 minutes moderate intensity

-walking, jogging, swimming

20 minutes of resistance exercise

Haskell W et al

Med & Science in Sports & Exercise 2007;39:1423-

Physical Activity

& Cancer Patients

Meta-analysis

45 Studies

• 27 Observational

• 11 Randomized CT

Results:

Exercise can improve

• Physical functioning

• Cancer related fatigue

Ballard-Barbash R et al

Jour Natl Cancer Inst, Online May 8, 2012

Giovannucci E, Jour Natl Cancer Inst, Online May 8, 2012

Bowel Cancer Risk

Resistance Exercises

WA Study:

Case control study

Results:

• Lower risk in each age group with resistance

training

Boyle T et al

Cancer Causes & Control

2012; 23:1091-

Calorie Intake Rises as

Sleep Time Drops

USA Study:

17 Healthy adults

Studied in laboratory for 8 days

Randomized to cut sleep by one-third or

sleep normally

Results:

Sleep restriction

• Raised caloric intake by 549 kcal per day

Calvin A et al

Epi/npam 2012; Abstract MP030

Exercise

& Insomnia

USA Study:

23 Sedentary adults

Sleep difficulties

Two groups: Exercise and Non-Exercise

Exercise 20 minute sessions four times a week

Results:

• Exercise improved sleep quality

ZeeP.et al

Sleep Med 2010 Oct

Prostate Cancer

Iceland Study:

Sleep loss

Systematic Review

16 Epidemiologic Studies

2 Meta-analysis

Results:

• Circadian disruption and sleep loss

• 15 Studies suggestive of association

• 10 Studies statistically significant results

Sigurdardottir L et all

Cancer Epid Biomarkers & Rev

On-line, May 7 2012

Obesity

UK Report:

• Shortens life by 13 years

• Smoking 10 years

The Foresight Report

250 leading UK scientists

10/2007

Obesity & Sleep

Australian Study:

40,834 Middle aged Australians

Results:

• Sleep <7 hours a night associated with

obesity

Magee CA et al

Epedemiology

2009; Oct 29 online

Obesity &

Low Vitamin D

Norwegian Study:

2,460 Men and Women

11 Years follow-up

12% obese initially

15% obese after 11 years

Results:

Vitamin D level below 50nmol/L associated with

obesity four times greater than 75nmol/L

Mai X et al

Amer Journ Epidem 2012; online

Cortisol ↑

Appetite ↑

Obesity & Stress

Stress Produces

Neuropeptide Y

Increases Fat Deposition

KMO L E et al

Natur Med 2007; 13:803-

Weight & Cancer

Mechanisms

New fat requires blood vessels

VEGF

CANCER CELLS

Beliveau R A et al

UICC World Cong 2012

Depression, Anxiety

& Life Expectancy

British Study:

Health Survey 1994-2004

68,000 Adults – aged 35+ years

8 year - follow-up

Mental health evaluation

Results:

• Symptoms of anxiety and depression resulted

in lower life expectancy Batty D et al

BMJ July 31, 2012

Breast Cancer

& Stress

USA Study:

1,000 recently diagnosed breast cancer patients

Measured psychosocial stress

Results:

• Those with greater levels of stress tended to

have more aggressive cancers

Rauscher GH, et al

4TH Amer Assoc Canc Research Conf

2011; September

Skin Cancer & Stress

USA Study:

Basal Cell Carcinoma (BCC)

91 patients with recurrent BCC

Early parent – child relationships

Severe life events in year prior to diagnosis

Results:

Immunity poorer if:

• Troubled early parent – child relationships

• Severe life events in year prior to diagnosis

Kiecolt-Glaser J (group)

Arch Gen Psych. 2012; 69:61p

Dogs in the Workplace

USA Study:

550 people employed in

service/manufacturing/retail company

20-30 dogs on premises each day

Psychological questionnaire

Results:

• Reduced stress

• Increased job satisfaction

Barker R.T. et al

Intern Jour Workplace Health Mgt

2012; Online March

Immunity &

Bereavement

UK Study:

24 Bereaved Participants

24 Control Participants

All aged 65+ years, Psychological assessment

Immunity measured

Results: Bereaved group -

• Depressed immunity

• Increased cortisol

Khanfer R et al

Brain Behav Immun

2011; 25:1182-

Mind/Body Medicine

Stress/Depression

(Mind)

Brain

PNI Abnormal Gut Flora PNE

Immunity Cortisol

Growth Hormone

Insulin Prolactin

MIND

(Storage)

Artery

Disease

Diabetes

Type 2 Growth

High G.I. Foods

MEDITATION

Plants & Cancer

Tumeric - Curcumin

• Most potent anti-inflammatory

• Can protect from cancer

Green Tea – epigallocatechin gallate

• Anti cancer invasion, metastasis and angiogenesis

Red Grapes - resveratrol

• Inhibits cancer cells

Cruciferous vegetables – sulforaphane

• Kills cancer

Beliveau R A et al

UICC World Cong 2012

Gut Bacteria

Placebo-controlled, Double Blind Study

20 Healthy men

14g Average fibre intake

Three groups

- Control – no fibre

- 21g polydextrose

- 21g soluble corn fibre

Results:

• Dietary fibre improves gut flora

Swanson K et al

J Nutri July 2012 PubMed on-line

Childhood Leukaemia

Maternal Folic Acid

Case Control Study

764 Acute Leukaemia

1,681 Controls

Folic Acid supplementation

Results:

Maternal folic acid supplementation reduces

risk of Ac.Leukaemia

Amigou A et al

Canc Causes & Control 2012, 23, 1265-

Vitamin E in Diet

Cancer Prevention

Cancer prevention by Vitamin E suggested

by many studies

• Synthetic α-tocopherol does not protect

• Delta and gamma tocopherols prevent cancer

• Found in soybeans and nuts

Yang C et al

Canc Prev Research. 2012; Online Arpril

Sunscreen &

Skin Cancer

USA Study:

Sunscreens containing Zinc Oxide

Zinc Oxide exposed to sunlight produces free

radicals

• Can damage DNA of skin cells

• Could increase risk of skin cancer

May Y

J Tox & App Pharma

2012 In Press

African American

Cancer Patients

USA Study:

Review of literature

Higher rates of cancer mortality in African Americans in comparison with Caucasians

African Americans have 40% lower vitamin D levels than Caucasians

Grant W & Peiris S

Dermato-Endocrinology

Online: June 2012

Breast Cancer &

Vitamin D

Belgium Study: Cancer size

Prospective study

1,800 early cancer patients

Follow-up 4 years

Vitamin D measured

Results:

• Lower Vitamin D significantly associated with

larger tumour size Brouwers B. et al

SABCS 12/2011

Prostate Cancer

& Vitamin D

USA Study:

Open-label trial

44 Low risk patients

Vitamin D supplementation – 4000 IU/Day

Repeat biopsy after one year

Results:

• 55% showed decrease in positive biopsies

• Decrease in Gleason score – 11%

Marshall D et al.

Jour Clinical End oc

April 2012: online

Non-Hodgkin

Lymphoma (NHL)

Early life sunlight exposure

1,009 NHL Patients

1,233 Controls

Vitamin D measured

Early life sunlight exposure noted

Results:

• Decrease in NHL risk with increased sun exposure

• Risk of NHL modified by Vitamin D related genes Kelly J et al

Cancer Causes & Control

2012; 23:1017-

Shoes

USA Study:

What your shoes say about you.

Study of college students

63 University of Kansas students looked at

photos of shoes of 208 owners of known personality

Students rated - personality, age, gender, income

Results:

Students could generally guess a stranger’s age,

gender, income and level of anxiety

Bahus A et al

Jour of Research in Personality

August 2012

Cancer Statistics

Australia 2010

113,700 New Patients

Excludes non-melanoma skin cancer

5% increase in three years

9% increase in women 2007

2% increase in men 2007

Aus t Inst of Health

2012

Cancer Risk Factors

Poor Lifestyle

accounts for 35% of all cancers

• Obesity, poor diet, lack of physical activity

• Similar risk to smoking

Beliveau R A et al

UICC World Cong 2012

Cancer & Stress

Stress-related psychosocial factors

Meta-analysis of 165 studies

Results:

• Higher cancer incidence

• Poorer survival if already have cancer

• Higher cancer mortality

Chida Y et al.

Nat. Clin. Pract. Oncol. 2008; 5:466-

Cancer Screening

USA Study:

Guidelines not recommend screening in adults

over 75 years

Data from National Health Review

Results:

Mammograms

• 62% of Women 75-79 years

• 50% of Women 80 years & older

Also high screening for cervical cancer, bowel cancer and prostate cancer

Bellizzi K et al

Arch Int Med 2011; 171:2031-

Cancer Survivors

USA Study:

1,807 Cancer survivors

18 year follow-up

Results:

776 Survivors died

• 51% died of cancer

• 49% other causes

More emphasis on prevention of other diseases

required.

Ning Y et al

AACR Ann Mtg 2012; Chicago

Cancer & Complementary

Therapies

Australian Study:

Review of Efficacy and Safety

400 Studies

50 Complementary therapies

Results:

• Help reduce symptoms and alleviate effects of

treatment.

• Top 10 Therapies: Relaxation; Support Groups;

Exercise; Music; Acupuncture; Massage; Omega-3

Fatty Acids; Yoga and Ginger

Pirri C et al

COSA 39th Ann Sc Mtg Nov 2012

Multivitamins in Prevention

of Cancer in Men

Physicians health study:

RCT Double blind study

14,641 Males – 50 years or older

1312 Males – History of Cancer

Daily Multivitamin supplementation

11.2 year follow up

Results:

• 8% reduction of total risk of Cancer

• 27% reduction of Cancer recurrence

Gaziano J. et al

JAMA 2012 Online

Smoking Cessation

Meta-analysis

Acupuncture and hypnotherapy most studied

Ten randomized controlled trials:

6 Acupuncture

4 Hypnotherapy

Results:

• Acupuncture and hypnotherapy can help

smokers quit

Tahiri M et al

Amer Jour of Med

Online, April 11, 2012

Lung Cancer Survival

USA Study:

Retrospective Study

Comparison of integrative cancer therapy with

control group

239 Patients integrative treatment group

11,853 Control Patients

Follow-up 1988-1993

McCulloch M et al

Integr Cancer

2011: August online

Lung Cancer Survival

Integrative Treatment

Lifestyle counselling, dietary advice, vitamin

and herbal supplements, plus fish oil

Results:

Integrative treatment group

• 50-85% reduced risk of death depending on

stage of cancer

• Difference in survival most dramatic in first

two years

McCulloch M et al

Integr Cancer

2011: August online

Bowel Cancer

Prevention & Nutrients

Canadian/Chinese Study:

1,760 Patients - bowel cancer

2,481 controls

Dietary questionnaire

Results:

Prevention of bowel cancer

• Increased intake of dietary calcium, Vit E, Vit D, riboflavin

and folate

Greater prevention in users of calcium, Vit C and folate

supplements

• Iron increased risk

Sun Z et al

Anticancer Research

2012, online Feb

Bowel Cancer &

Curcumin

UK Study:

Laboratory Study

Combination of chemotherapy and curcumin in

metastatic bowel cancer cells

Results:

Can enhance chemotherapy’s ability to kill bowel

cancer cells involving cell cultures

Steward W. et al

Leicester, England May 2012

Bowel Cancer

& Fish Consumption

Systemic review and meta-analysis

22 Prospective Cohort

19 Case-control studies

Results:

Fish consumption is inversely associated with

bowel cancer

Wu S et al

Amer Jour of Med

Online, April 17, 2012

Bowel Cancer

& Yoghurt

Italian Study:

14,178 Men

31,063 Women

Diet including yoghurt consumption

12 Year follow-up

Results:

• 289 developed bowel cancer

• Yoghurt consumers, less risk of cancer

Pala V. et al

Int Jour Canc 2001; 129:2712-

Bowel Cancer

Recurrence & Diet

1,011 Stage 111 Bowel Cancer Patients

Diets during adjuvant therapy and 6 months after

Results:

• High carbohydrate and glycaemic index diets

reduced survival

Meyerhardt JA et al

JNCI 2012 on-line

Breast Screening

UK Study:

Government panel. Meta-analysis

10,000 Women invited for screening

681 Cancers found

129 Over diagnosis

43 Lives saved

20 year follow-up

20% lower relative risk of dying from cancer

Marmot Met al

Lancet 2012

Mammography

Screening

Swedish Study:

Women aged 40-69

Screening since 1969-2009

Results:

• Mammography screening has limited or no

impact on breast cancer mortality

Autier P et al

JNCI 2012, 104, 1080-

Breast Cancer &

Screening

As detected by mammography

Nearly 120,000 Women

Aged 50-64

Mammography over six-year period

Compared to

Nearly 110,000 Women

Same age as above

Mammography only at end of six year period

Result

• 22% more cancer in group who had two yearly mammograms

Zahl P et al

Arch Int Med 2008; 168-2311-

Mammography Benefits

& Harms

Australian Review:

Over-diagnosis

Non dangerous cancers diagnosed

About one third of cancers not dangerous

Screening overstates the benefit and

understates the harm.

Barrett A et al

Editorial

MJA 2012; 196:681

Breast Cancer &

Telomere length

USA Study:

Population case/control study

1,067 Breast cancer patients

1,110 controls

Telomere length of white blood cells

Results:

• Shorter telomere length association with

increased breast cancer risk.

Shen J. et al

Inter Journ Cancer 2009; 124:1637-

Breast Cancer

& Resveratrol

USA & Italian Study:

Laboratory study

Breast Cancer cells

Resveratrol (red grapes) added

Results:

• Resveratrol reduced cell growth

• Resveratrol reduced oestrogen receptors

De Amicis F et al

FASEB Jour 2011; 25- online

Breast Cancer

& Multivitamins

USA Study:

2,236 Women with early stage breast cancer

Multivitamin use pre and post diagnosis.

Results:

• Multivitamin use pre and post was associated

with decreased risk of recurrence

Kwan ML et al

Breast Can Res Treat. 2011; 130:195-

Metastatic Breast

Cancer & Yoga

Indian Study:

Randomised trial

45 Patients – daily yoga

46 Patients – standard counselling

Results:

Yoga Group

• Improved psychological state (anxiety, depression,

fatigue)

• Decrease in salivary cortisol

• Improved immunity

Gupinarth SK et al

34TH Ann San Antomio

Breast Ca Symposium 12/2011

Breast Cancer Survivors

US/China Study:

Prospective Study

4,886 Chinese breast cancer survivors

36 month follow-up after diagnosis

Results:

• Cruciferous vegetables reduced risk - total

mortality, breast cancer mortality and recurrence

• Highest intake – 62% reduced cancer mortality

- 35% reduced recurrence

Nechuta SJ et al

Amer Assoc Cancer Research Ann Mtg Chicago 2012

Breast Cancer Survivors

& Fatigue

Cohort of 633 survivors

Measured CRP

Intake of Omega-3 cf Omega-6

Results:

Lowest Omega-3 relative to Omega-6

• Higher CRP

Those having Omega-3 supplement had

• 2.6 fold decreased risk of fatigue

J Clinc Oncol

2012; Online

Breast Cancer Survivors

USA Study:

Fatigue

About one third of breast cancer survivors have fatigue.

31 Breast cancer survivors with fatigue

3 Months of twice weekly yoga

Results:

Yoga Group

• 55% increase in energy

• Continued three months after yoga cessation

Bower J et al

Cancer, online 12/2011

Prostate Cancer

& Curcumin

USA Study:

In Vitro study

Prostate cancer cells (hormone resistant)

with and without curcumin

Results:

• Curcumin potent inhibitor of prostate cancer cells

Shah S.A. et al

Can Res 2012: online

Prostate Cancer

& Soy

USA Study:

Treatment-resistant cancer

10 men with treatment-resistant prostate cancer

Three servings of soy daily for two years

Results:

After two years

• Half of men reduced PSA

Joshi M et al

Southern med Jour 2011, Nov.

Prostate Cancer

& Pomegranate

USA Study:

Multi-centre, double-blind study

104 prostate cancer patients with rising PSA

18 month follow-up

Pomegranate Extract (POMx) 1gm or 3gms

Results:

• Pomegranate decreased PSA increase

Poller Cet al

J our Clin Oncology 2011, 29 Abs4522

Photo-dynamic Diagnosis

(PDD)

Eleanor R et al

The Urology Centre & Dep Histopathology. BJUI

International

Photo-dynamic Diagnosis

(PDD)

The role of hexylaminolaevulinate in the diagnosis and follow-up of non-muscle-invasive bladder cancer

Colin Bunce1,et all

online: 15 JAN 2010 BJU International

Circulating Tumour

Cells (CTCs)

• CTC’s are cells shed from a primary cancer

and enter the blood stream, with the potential

to spread

• Cells can be isolated and cultured

• Cells can be tested for sensitivity to

chemotherapy, special receptors and

supplements.

CTC Counter

Hyperthermia &

Cancer

Tumour Treatment Effect with

HT

Effect without

HT

Melanoma RT+/-LHT 62% 35%

Breast RT+/-LHT 59% 41%

Cervix RT+/-LHT 83% 57%

Bladder RT+/-LHT pre-op 94% 67%

Oesophagus RT+/-LHT 42% 24%

Soft tissue

sarcoma

CT+/-LHT 28.7% 12.6%

Oesophagus RT+CT+/-LHT pre-

op

70% 8%

Van Der Zee J et al

Intnl J Hyperthermia, 2008;24:111-

NGPDT

NIIM Study:

• New photosensitising agent (Photosoft)

• New laser delivery system

• Light Bed

103

Patients

10 Cancer Patients (8 women, 2 men)

Breast– 4

Salivary– 1

Neck– 1

Cervical – 2

Pancreatic – 1

Liver secondary - 1

Aged 35-81 years

Primary or metastatic cancer

No other cancer therapies

104

Treatment

Photosoft sensitiser

All patients treated with light bed (30 minutes)

and external laser (30 minutes)

Three cycles of treatment (monthly) over 3 months

• each cycle on 4 alternate days

105

Photosoft Light

Absorption Graph

108

Results

No phototoxic or other side effects from treatment.

Scanning results 3 months post completion.

• All patients had progression of disease.

• One breast cancer patient had response of

superficial skin chest secondaries, but not

internal cancers

109

Prostate Cancer Treatment

Photodynamic and Sonodynamic

Therapy (PDT, SPDT & NGPDT,)

Donald Murphy

Brian Meade

Avni Sali

NIIM Study

Photodynamic &

Sonodynamic therapy

Non-toxic sensitisers

• produce cytotoxic reactive singlet oxygen, which

can kill cancer cells

• decreases tumour vascularity

• stimulates the host immune system

Castano A. et al

Nature Reviews Cancer 2006, 6,53-

Patients

66 Patients, Aged 57 - 79 years

• Three groups, each 22 patients

First 33 patients:

Biopsy proven Prostate Cancer:

• Focal Disease (25 patients)

• Persisting Cancer after radical treatments (8

patients)

Patients

• Photosensitiser agents:

a. Radachlorin (Russia)

b. Sonalux (USA)

c. Photosoft (China)

• Energy sources:

Light and Sound / Light combined

Treatment Protocol

Outpatient procedure

Sensitiser – sublingual 24 hours before treatment cycle

Laser plus ultrasound for 3 days

• Combination of trans-rectal, trans-urethral and per-cutaneous

techniques

• Treatment delivered AM and PM (25 min max.) for 3 days

• Treatment cycles at week 1 and 2

Post Prostatectomy

- laser illumination

Results

33 patients have been entered to date

• 21 completed treatment > 6 months

• 7 completed treatment < 6 months

• 5 currently undergoing treatment

116

Results

21 Patients > 6 months follow-up

• 12 patients - stable or decreasing PSA

• 9 Patients - PSA rise

• trans perineal prostate and +/- TUR biopsies

- 4 negative and 5 positive

117

Results

Both sensitisers and PDT & SPDT (NGPDT

preliminary) were shown to be safe.

• Prostate size decreasing

• Improvement in flow rates

• No urinary incontinence

• No alteration in erectile function

Conclusions

• Sensitisers - no systemic toxicity or sun

sensitivity

• No rectal injuries

• PDT, SPDT & NGPDT may have a significant

role in future treatment of prostate cancer

Advanced Cancer

Patients

Korean Study:

Health related quality of life

High Dose Intravenous Vit C

39 Advanced Cancer Patients

Vit C IV – 10gm over 2 days,

after 3 day, oral 4gm for one week

Results:

• Quality of life improved

• Better cognition

• Physical function

• Lower fatigue

• Less Nausea, Vomiting, Pain & Appetite loss

Yeom C et al

J Korean Med Sci 2007, 22,7-

Vitamin C improves

mood in acutely

hospitalized patients

Canadian Study:

55 Patients with various chronic illnesses

6 Week period

Double Blind Study

Vitamin C 500mg x2 daily

Assessment of Mood

Results:

• Vitamin C increased leukocyte Vitamin C concentrations

• 35% reduction in mood disturbance

Zhang M et al

Nut 2010 on-line

Breast Cancer &

Intravenous Vitamin C

German Study:

Cohort Study

53 Breast cancer patients

72 Control group

IV Vitamin C - 7.5g

Chemotherapy/Radiotherapy

Results:

• Reduction in most side effects

• No side effects of IV Vitamin C

Vollbracht C et al

2011; 25: 983-

IV Vitamin C combined

with Gemcitabine &

Erlotinib

Patients with metastatic pancreatic cancer

14 Patients

Short-term study

Results:

• No increased toxicity with combined IV Vit C and

drugs

• Response to treatment

Monti D et al

PLoS one 2012, Vol 7

Intravenous Vitamin C

as Cancer Therapy

High dose IVC

Humans

• Several reports

Padayatty SJ et al Drisko J et el

(Levine M) J Am Col Nutr

CMAJ 2006;174:937- 2003;22:118-

IIn Vitro

• Lipoic acid synergistic

• Vitamin K3

Casciari JJ, Riordan HD et al

Br J Cancer 2001;84:1544-

High Dose

Intravenous Vitamin C

Effect on:

• Inflammation & Cancer

45 Patients – various cancers

IV Vitamin C (7.5 – 50g)

Results:

Inflammation response

• IVC 75%

• Control 25%

Cancer markers

• Correlated with inflammation response

Casciari J A et al

Jour Trans Med 2012, 10 On-line

Breast Cancer &

Hot Flashes

Acupuncture

47 breast cancer patients with drug related hot flashes

Treatment

-Antidepressant – Venlafaxine (Effexor)

-Acupuncture

• Acupuncture as good in decreasing hot flashes, no side effects of drug

Chustecka Z et al

Am Soc Therapeutic Radiol & Oncol

50th Ann Conf 2008

Chemotherapy

Fatigue

Acupuncture

47 cancer patients with chemotherapy fatigue

Randomised/placebo trial

6x20 minute sessions of acupuncture

• Acupuncture group

• 36% improvement in fatigue

• 0.6% improvement in placebo group

Molassiotis A et al

Complem Therapies in Med

2006 - online

Cocoa Flavanols/

Procyanidins & Cancer

In-vitro studies show that cocoa chemicals

inhibit breast, prostate and bowel cancer

cells.

Cocoa use may have clinical significance in

cancer patients.

Jourdain C et al

Euro J Cancer Prev 2006, 15, 353-

Ramljack D et al

Mol Cancer Ther 2005, 4 537-

Carnesecchi S et al

Cancer Letters 2002, 175; 147-

Dark Chocolate &

Heart Disease

National Institute of Integrative Medicine

Cochrane review

20 Trials

856 People – Duration 2-8 weeks

Consumed 3-100gm chocolate per day

Results:

• High flavanols reduced blood pressure

Ried K et al

Cochrane Reviews Iss 8 2012

Cocoa & Mental

Wellbeing

Flavanol-rich cocoa has been shown to

improve mood and reduce stress.

Smith D F

Journ Funct Foods 2012, on-line

Chocolate &

Nobel Prizes

List of countries ranking Noble Prizes

per country.

Data on per capita chocolate consumption per

10 million people, chocolate (dark) is known

to improve cognition.

Results:

Powerful correlation between chocolate

consumption and the number of Noble Prize

winners. Messerli FH

New Eng J Med 2012 on-line

Regorafenib &

Metastatic Bowel Cancer

RCT:

760 Patients – Metastatic Bowel Cancer

Placebo Group

Results:

Survival

• Drug group – 6.4 months

• Placebo group – 5 months

Cost per month for Regorafenib $11,500

Van Cutsem E et al

Amer Soc Clin Onc Ann Mtg 2012

Drug Company Fines

2007 Bristol-Myers Squibb $515 Million

2008 Purdue Pharma $634.5 Million

2009 Eli Lilly $1.4 Billion

2009 Pfizer $2.3 Billion

2010 Astra Zeneca $520 Million

2011 Merck $950 Million

2012 Abbott $1.5 Billion

2012 Glaxo Smith Kline $3.0 Billion

Mercola 2012: on-line

“Sir John Gurdon, Nobel Prize Winner,

was „too stupid‟ for science at school”

- The Telegraph

At the age of 15, Prof Sir John

Gurdon ranked last out of the

250 boys in his Eton year group

at biology, and was in the bottom

set in every other science

subject.

The recent decision by French

President Francois Hollande to abolish

homework from French schools has

reignited the long running debate about

homework.

Nov 2012

Stamatis in Ikaria