Product &Technical InformationProfessional Reference Only.

Fertility FormulaFemale.

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Product & Technical InformationProfessional Reference Only.

Fertility FormulaFemale.

Mygen Health’s Female Fertility Formula is a complete and comprehensive supplement, providing your patients with the best support in pre-natal and early pregnancy care.

Mygen Health’s Premium Fertility Formula contains readily absorbable, therapeutic levels of vitamins, minerals and antioxidants, necessary for conception and a healthy pregnancy. Research indicates that optimal nutrition before and during pregnancy is vital for reducing the following adverse outcomes in mother and baby:

For Baby:

> Low birth weight> Neural tube defects > Congenital birth defects> The risk of developing chronic disease later in life

For Mother:

> Conception difficulties in older women> Pre-eclampsia> Pre-term delivery> Pregnancy complications> Placental issues

Comparefor yourself!

Use the table to see how Mygen Health’s Formula performs against other pre-natal supplements available on the market.

DuoPackaging:

Mygen Health’s Female Fertility Formula comes in a duo pack for the better absorption and availability of both water and fat soluble nutrients:

> Capsules - fat soluble nutrients; and> Tablets - water soluble nutrients

* Calcium folinate is a source of folinic acid, which quickly converts to the most active form of folate. Folinic acid, as an active form of folic acid aids in overcoming common inherited polymorphisms that may impair folic acid availability. **Folic acid is essential pre-conceptionaly, however, its absorption is dependent on the presence of adequate levels of all B vitamins.

Bioceuticals InNatal plus Iron

As 250mcg Folic Acid

10mg

10mg

13mcg

60mg

350mcg

B1, B2, B3, B5, B6. Total 152mg

135mcg

As Iron Amino Acid Chelate

400IU

As 100mg Ascorbic Acid

45mcg

20mcg in Chromium nicotinate form

Blackmores Conceive Well

As 500mcg Folic Acid

15mg

65mcg

60mg

50mcg

B1, B2, B3, B5, B6. Total 78mg

150mcg

As Ferrous Fumarate

400IU

As 200mg Ascorbic Acid

Bayer Elevit with Iodine

As 800mcg Folic Acid

11mg

50mcg

2.6mcg

B1, B2, B3, B5, B6. Total 28.7mg

220mcg

As Ferrous Fumarate

200IU

As 85mg Ascorbic Acid

> FOLATE

> ZINC

> CHOLINE

> SELENIUM

> COQ10

> VITAMIN B12 > OTHER B GROUP VITAMINS**

> LIPOIC ACID

> IODINE

> IRON

> VITAMIN D

> VITAMIN C

> VITAMIN K

> CHROMIUM

MetagenicsPregency Care

As 500mcg Folic Acid

25mg

100mcg

500mcg

50mg B6 only

299mcg

As Iron Amino Acid Chelate

1000IU

60mcg

50mcg in Chromium nicotinate form

Mygen HealthFertility Formula

As 500mcg Calcium Folinate*

25mg

200mg

75mcg

100mg

400mcg

B1, B2, B3, B5, B6. Total 285mg

100mg

200mcg

As Iron (II) Glycinate

1000IU

As 200mg Ascorbic Acid

100mcg

50mcg Chromium Picolinate + 50mcg Chromic Chloride

NutrimedicineNatal Complete

As 250mcg Folic Acid

10mg

50mg

13mcg

250mcg

B1, B2, B3, B5, B6. Total 228mg

30mg

80mcg

As Iron Amino Acid Chelate

150IU

1000mcg Chromic Chloride

Fertility FormulaFemale.

The active ingredients in Mygen Health’s Fertility Formula are:

> Tablets:

Iodine (as Potassium Iodide) 200mcg

Iron ( II) glycinate 20mg equiv Iron 5mg

Calcium Folinate (folate) 500mcg

Thiamine hydrochloride (Vitamin B1) 50mg

Riboflavin (Vitamin B2) 50mg

Nicotinamide (Vitamin B3) 75mg

Manganese (as manganese amino acid chelate) 10mg

Zinc (as zinc citrate dihydrate) 25mg

Pyridoxine hydrochloride (60.1mg)

equiv pyridoxine (Vitamin B6) 50mg

Pyridoxal-5-phosphate (10mg)

equiv pyridoxine (Vitamin B6) 6.5mg

Cyanocobalamin (Vitamin B12) 400mcg

Magnesium (as magnesium citrate) 25mg

Ascorbic acid (Vitamin C) 200mg

Selenium (as Selenomethionine) 75mcg

Calcium pantothenate (55.6mg)

equiv pantothenic acid (Vitamin B5) 50mg

Calcium (as calcium citrate hydrate) 50mg

Chromium (as chromic chloride) 50mcg

Chromium (as chromium picolinate) 50mcg

Molybdenum (as molybdenum trioxide) 50mcg

R,S-alpha lipoic acid 100mg

Biotin 100mcg

Choline Bitartrate 209mg

> Capsules:

Ubidecarenone (Coenzyme Q10) 100mg

Cholecalciferol (Vitamin D3 1000IU) 25mcg

Phytomenadione (Vitamin K) 100mcg

Betacarotene 3mg

Tocopherols concentrate - mixed (high alpha type) 168mg

equiv d-alpha Tocopherol (Vitamin E) 200IU

The pre-natal benefits of many of these ingredients are listed below:

> Folic acid

> Folic acid is required for healthy cellular division and early growth and development of the foetus and placenta.

> It is well recognised that folic acid supplementation by the mother, before pregnancy and during the1st trimester, may reduce the foetus’ risk of chromosomal abnormalities and neural tube defects of the brain or spinal cord, such as spina bifida and anencephaly.

> Folinic acid aids in overcoming common inherited polymorphisms that may impair folic acid availability.

> Research has shown that many people struggle to effectively metabolise folic acid into the active form. Mygen Health’s Fertility Formula provides folate in an activated form - as calcium folinate - which has been shown to raise plasma folate more efficiently than other forms of folic acid supplements.1

> Choline

> Choline is important for healthy cell membrane, structure and signalling, and may reduce miscarriage risk.

> Choline has been found to protect against neural tube defects,2 and is important for healthy genetic expression.

> Choline supplementation during pregnancy has been associated with improved offspring cognitive function.3

> Research is now highlighting the importance of choline during pregnancy and lactation, with many studies showing that pregnant women often have inadequate choline levels.4

> Chromium

> Chromium is necessary for proper insulin receptor functioning.

> Chromium supplements have been found to improve impaired glucose tolerance and reduce insulin levels in women diagnosed with gestational diabetes.5

> Chromium can be beneficial in maternal weight loss. Chromium may prevent issues associated with elevated blood sugar levels and insulin resistance which are commonly implicated in women who have been diagnosed with PCOS.

> Selenium

> Selenium is an important nutritional antioxidant and supports a healthy pregnancy. It plays a role in thyroid hormone production and supports the function of the immune system.

> The Recommended Dietary Allowance (RDA) for selenium increases during pregnancy and selenium is necessary for 1st trimester maternal health.9

Product & Technical InformationProfessional Reference Only.

> B vitamins

> B vitamins are necessary for normal hormone production and support the expression of healthy DNA.

> B12, like folic acid, plays a role in healthy cell replication making it important during pregnancy when foetal cells are quickly dividing and differentiating.

> Higher B12 and folic acid levels found in fluids surrounding reproductive organs positively correlate with successful pregnancy outcomes.

> A deficiency in B vitamins may result in impaired methylation and elevated homocysteine levels in pregnant women.

> Elevated homocysteine levels have been associated with pregnancy complications such as pre-eclampsia, miscarriage, placental abruption and abnormal foetal growth.7 B vitamins at therapeutic levels are necessary to combat these risks.

> The active forms of both B6 and folic acid have been included in Mygen Health’s Fertility Formula as they have been found to support healthy methylation processes that are required during pregnancy.8

> Vitamin D

> Vitamin D is necessary for healthy ovulation and uterine function.10

> Vitamin D has also been found to play a role in the synthesis and regulation of female hormones.

> During pregnancy, vitamin D is necessary for foetal development, birth weight, skeletal and teeth development and vital for healthy bone mineral density in the mother.11

> Vitamin D will also reduce the risk of premature delivery and pre-eclampsia.12

> Vitamin D deficiency is increasingly common in pregnant women.

> Vitamin C

> Vitamin C is a powerful antioxidant, found to be necessary for egg production and maturity.

> Vitamin C supplementation has been associated with increased fertility.

> Lipoic Acid

> Lipoic acid is a powerful antioxidant and mitochondrial nutrient that enhances the function of vitamins C and E and other antioxidants.

> Alpha lipoic acid can reduce oxidative damage generated through diet, age and toxic exposure.

> Alongside chromium, lipoic acid may help to maintain healthy blood sugar levels.

> Coenzyme Q10

> CoQ10, an antioxidant, is found in the mitochondria of the body’s cells where it plays an essential role in the production of cellular energy.

> Studies have suggested CoQ10 has a beneficial role in supporting early pregnancy health.13

> Further studies have confirmed a progressive increase in maternal CoQ10 requirements throughout the 2nd and 3rd trimesters.14

> CoQ10 can improve 3rd trimester maternal wellbeing and aid in the maintenance of cardiovascular, placental and blood vessel health of the mother.

> Iron

> After supplementation, iron has been shown to benefit both ovulation function and fertility.15

> Iron is a common deficiency in pregnant women.

> Mygen Health’s Fertility Formula provides iron as iron (II) glycinate allowing for improved absorption.

> Zinc

> Zinc is necessary for early cell division and embryonic development.

> Adequate levels of zinc are necessary for hormonal production, normal conception and the healthy development of the baby in utero.

> Zinc supplementation has been found to reduce the risk of premature delivery.16

> Mygen Health’s Fertility Formula provides zinc in the very bioavailable citrate form.

> Iodine

> Iodine is necessary for hormone production and critical for 1st trimester maternal health.17

> Iodine is necessary for normal neurological development of the foetus. The National Health and Medical Research Council (NHMRC) has advised all pregnant and breast feeding women, and those considering pregnancy, to take a supplement containing 150mcg of iodine.18

> Iodine deficiency has been associated with reduced fertility, hypothyroidism, intellectual deficits in babies, miscarriage and impaired embryonic foetal development.19-21

> In Australia, iodine deficiency is becoming increasingly common, with up to 40% of children and pregnant and breastfeeding women being found to be iodine deficient.

> The World Health Organisation has now classified Australia as a mildly iodine deficient country.22

> Mygen Health’s Fertility Formula provides adequate levels of iodine to help reduce the risk of this common deficiency.

> References

> 1. R Prinz-Langenohl et al. [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C.T polymorphism of methylenetetrahydrofolate reductase. British Journal of Pharmacoloyg. 2009, 158. 2014-2021.

> 2. Shaw GM, Carmichael SL, Yang W et al. Periconceptional dietary intake of choline and betaine on neural tube defects in offspring. Am J Epdiemiol. 2004; 160:102-109.

> 3. Blusztajn JK, Mellott TJ. Neuroprotective actions of perinatal choline nutrition. Clinical Chemistry and Laboratory Medicine. 51; 3: 591-599.

> 4. Claudill MA. Pre and postnatal health: evidence of increased choline needs. J Am Diet Assoc. 2010 Aug:110(8):1198-206.

> 5. Jovanovic L et al. J Trace Elem Exp Med 1999;12:91-7.

> 6. Boxmeer, J.C. et al. IVF outcomes are associated with biomarkers of the homocysteine pathway in monofollicular fluid. Human Reproduction. 2009 24(5), 1059-1066.

> 7. Kim KN et al. Eur J Clin Nutr 2004; 58:10-6.

> 8. Kauwell GP, Wilsky CE, Cerda Jj et al. Methylenetetrahy drofolate reductase mutation (677C›T) negatively influences plasma homocysteine response to marginal folate intake in elderly women. Metabolism. 2000, 49(11):1440-1443.

> 9. NICHD (National Institute of Child Health & Human Development). Care before and during pregnancy – prenatal care. http://www.nichd.nih.gov/womenshealth/re search/pregbirth/prenatal_care.cfm Accessed 10/10/2008.

> 10. Lewis S, Lucas RM, Halliday J, Ponsonby AL. Vitamin D deficiency and pregnancy: from preconception to birth. MolNutr Food Res. 2010 Aug;54(8):1092-102.

> 11. Javaid MK, Crozier SR, Harvey NC, Gale CR, Dennison EM, Boucher BJ, Arden NK, Godfrey KM, Cooper C; Princess Anne Hospital Study Group. Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. Lancet. 2006 Jan 7; 367(9504):36-43.

> 12. Mulligan ML, Felton SK, Riek AE, Bernal-Mizrachi C. Implications of Vitamin D deficiency in pregnancy and lactation. American Journal of Obstetrics and Gynecology. May 2010;202(5):429.e1-429.e9.

> 13. Noia G, Littarru GP, De Santis M, Oradei A, Mactrom arino C, Trivellini C, Caruso A. Coenzyme Q10 in pregnancy. FetalDiagnTher. 1996 Jul-Aug;11(4):264-70.

> 14. Niklowitz P, Menke T, Giffei J, Andler W. Coenzyme Q10 in maternal plasma and milk throughout early lactation. Biofactors. 2005;25(1-4):67-72.

> 15. Chavarro JE et al. Iron intake and risk of ovulatory infertility. Obstet Gynecol. 2006 Nov;108(5):1145-52.

> 16. Mahomed K et al. Cochrane Database Syst Rev 2007;(2):CD000230.

> 17. Tancred J. All eyes on iodine. Complementary Medicine May/June 2006; 56-61.

> 18. NHMRC. Public Statement: Iodine supplementation for pregnant and breastfeeding women. Commonwealth of Australia 2010.

> 19. Perez-Lopez FR. Gyn Endocrin 2007; 23(7): 414-28.

> 20. Vermiglio F et al. J Clin Endocrinol Metabol 2004; 89: 6054-60.

> 21. Zimmerman MB. Am J Clin Nutr 2009; 89: 668-72.

> 22. NHMRC. Literature Review: Iodine supplementation during pregnancy and lactation. Commonwealth of Australia 2009.

Designed by health professionals and manufactured in Australia to the highest quality standards, each Mygen Health Formula provides maximum consumer benefit without compromise on quality or strength.

Mygen Health is an Australian vitamin and mineral supplement company. Our formulas are designed to address the different nutritional needs of men and women throughout their various stages of life. Mygen Health’s formulas contain therapeutic concentrations of nutrients that have clear clinically proven benefits, in forms that the body can easily absorb.

> Product

> Fertility Formula Male AUST L 205 447

> Vitality Formula Male AUST L 205 448

> Product

> Maternity Formula AUST L 244 238

> Fertility Formula Female AUST L 206 185

Mygen Health has created tailored formulas for pre-conception, pregnancy and breastfeeding for women and a separate pre-conception formula for men:

Information in this brochure was correct at the time of publishing. Published March 2016.

> Size

> 30 Morning Tablets and 60 Evening Tablets (30 days supply).

> 30 Capsules and 30 Tablets (30 days supply).

> Size

> 30 Capsules and 30 Tablets (30 days supply).

> 30 Capsules and 30 Tablets (30 days supply).

If you would like to know more or to request research abstracts please contact:

Telephone 1800 723 012sales@mygenhealth.com.au www.mygenhealth.com.au

Mygen Health Pty Ltd1 Karingal Rd Riverview NSW 2066 Australia

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