Product Catalogue - Cientisol · Product Catalogue The NGAL Test ... catalog number. All the...
Transcript of Product Catalogue - Cientisol · Product Catalogue The NGAL Test ... catalog number. All the...
Diagnostics
Product CatalogueThe NGAL Test™ Antibodies ELISA kits
ISO 13485 certified
Featured areas:NGAL
Peptide hormonesComplement
2Diagnostics
3Diagnostics
Market Leadingbiomarkers and antibodies BioPorto Diagnostics offers a strong range of antibodies, which can be used for develop-ing diagnostic immunoassay kits within several disease areas, and we have established us as a trusted supplier of high quality and unique antibodies and ELISA kits. Combined with our high dedication to develop and offer new, market leading antibodies on a con-tinued basis, we now experience that our antibodies are widely used for a broad range of research purposes.
It is our clear goal to provide physicians and researchers with novel diagnostic biomarkers addressing unmet clinical needs in order to establish standards of care with focus on early diagnosis and limitation of life threatening medical conditions.
BioPorto Diagnostics is committed to the highest level of quality in the manufacture, sale and support of its products. Quality and compliance with all applicable regulatory requirements and customer satisfac-tion must underlie the company’s efforts in manufacturing, advertising, sales, shipping and technical support.
BioPorto is ISO 13485:2012 certifi ed and holds an ISO 13485:2012 certifi cate under CMDCAS.
Focus on Quality through all product stages
Committed Research & Development secures unique productsOur dedicated approach to identify and target biomarkers addressing unmet clinical needs in the management of acute conditions has enabled us to offer a novel biomarker for the diagnosis of acute kidney injury. We have launched The NGAL Test™, a market leading unique immunoassay solution for early risk assessment of acute kidney injury in several medical and surgical specialties.
Our dedicated focus on the development of antibodies for research on nephrotoxicity has resulted in a unique range of available NGAL animal and human antibodies, which ena-bles researchers to focus on kidney damage throughout the drug development process – hereby we have been able to bridge the gap between drug discovery, pre-clinical research and human clinical trials.
Clinical Chemistry
4Diagnostics
Human NGAL 5Animal NGAL 5
*
Human NGAL 5MBL 5
Quick product range
overview
*
The NGAL Test™ 6
Antibodies
Alphabetic list of antibodies 7
Featured areas:NGAL 12
Peptide hormones 13Complement 14
Sera
MBL 11
Human IgE 11Human NGAL 11Animal NGAL 11
* For in vitro diagnostic use in selected countries only. See www.bioporto.com for availability in your country
ELISA kits Antigens
5Diagnostics
ELISA kitsMarket leading and ready-to-use ELISA kits.
* For in vitro diagnostic use in selected countries only. See www.bioporto.com for availability in your country
Human NGAL Changing the diagnosis and management of Acute Kidney Injury (AKI) *
Cat. No. Name Assay range Size
KIT 037 NGAL Rapid ELISA Kit 0.2-20 ng/mL 96 wells
WASH 037-30 25x Wash Solution Concentrate KIT 037 30 mL
WASH 037-250 25x Wash Solution Concentrate KIT 037 250 mL
MBL Key test in the assessment of Primary Immune Deficiency (PID) *
Cat. No. Name Assay range Size
KIT 029 MBL Oligomer ELISA Kit 0.50-40 ng/mL 96 wells
WASH 029-30 25x Wash Solution Concentrate KIT 029 30 mL
WASH 029-250 25x Wash Solution Concentrate KIT 029 250 mL
Human NGAL When assay sensivity matters in NGAL research RUO
Cat. No. Name Assay range Size
KIT 036 NGAL ELISA Kit 10-1000 pg/mL 96 wells
WASH 036-30 25x Wash Solution Concentrate KIT 036 30 mL
WASH 036-250 25x Wash Solution Concentrate KIT 036 250 mL
Animal NGAL Nephrotoxicity through all drug development stages RUO
Cat. No. Name Assay range Size
KIT 042 Mouse NGAL ELISA Kit 10-1000 pg/mL 96 wells
KIT 043 Dog NGAL ELISA Kit 4-400 pg/mL 96 wells
KIT 044 Pig NGAL ELISA Kit 10-400 pg/mL 96 wells
KIT 045 Monkey NGAL ELISA Kit 10-1000 pg/mL 96 wells
KIT 046 Rat NGAL ELISA Kit 4-400 pg/mL 96 wells
00
0.8
1.5
2.2
3
250 500 750 1000
NGAL (pg/mL)
OD
Human NGAL ELISA Kit (KIT 036) - Calibration curve
6Diagnostics
Clinical ChemistryThe NGAL Test™ - Novel and unique biomarkerfor diagnosing acute kidney injury at an early stage.
* For in vitro diagnostic use in selected countries only. See www.bioporto.com for availability in your country
The NGAL Test™ *
Cat. No. Name Contents
ST001CA The NGAL Test™ - Reagent kit Immunoparticle Suspention, 7 mL Reaction Buffer, 35 mL
ST002CA The NGAL Test™ - Calibrator kit 5 vials of 1 mLPrediluted calibrators
ST003CA The NGAL Test™ - Control kit 6 vials of 1 mLControl Low, 3 x 1 mLControl High, 3x 1 mL
The NGAL Test™ - a particle-enhanced turbidimetric immunoassay for the quantitative determination of neutrophil gelatinase-associated lipocalin (NGAL) on automated chemistry analyzers.
Onlyacute kidney injury
diagnostic biomarker using both
human urine and plasma
7
Monoclonal antibodies
Specifi city Application Cat. No.
Acetylcholinesterase (bovine brain, AChE) ELISA, WB HYB 101-03
Acetylcholinesterase (human brain, AChE) ELISA, WB HYB 111-05
Acetylcholinesterase (human brain, bovine brain, AChE) ELISA, WB HYB 190-01
Adrenomedullin (human) ELISA ABS 027-01
Albumin, bovine serum (BSA) ELISA, WB HYB 267-01
Albumin, bovine serum (BSA, denatured) ELISA HYB 261-02
Albumin, human serum (HSA) ELISA, WB >1 clone
Albumin, human serum (HSA, denatured) ELISA, WB >1 clone
Alkaline phosphatase (AP) ELISA HYB 252-08
alpha1-Antitrypsin (human, alpha1- AT, native and denatured) ELISA, WB HYB 191-01
alpha-calcitonin gene-related peptide (alpha-CGRP) ELISA, IHC >1 clone
alpha-Fetoprotein (human, AFP) ELISA >1 clone
Amodiaquine ELISA HYB 320-04
Amyloid beta-peptide (human) ELISA, AP >1 clone
Antithrombin III (human) ELISA, WB >1 clone
Antithrombin III (human, denatured) ELISA, WB HYB 228-12
Antithrombin III (human, native and denatured) ELISA, IHC HYB 228-08
APC–AAT complexes, neoepitope (human) ELISA ABS 001-07
Apolipoprotein A-1 (human) ELISA, WB HYB 069-01
Apolipoprotein B (human) ELISA, WB >1 clone
Aprotinin ELISA (matched pair), WB >1 clone*
Antibodies are listed according to their antigen and with information about applications and catalog number.
All the antibodies are mouse monoclonal affi nity purifi ed 1 mg/mL.
Antibodies marked with * are also available biotinylated and delivered at a concentration of 1 mg/mL.
If the antibody you are looking for erstat med is marked with >1 clone, please visit our web-site www.bioporto.com/products or feel free to contact us at [email protected].
Abbrivations: AP: Affi nity purifi cation ELISA: Enzyme Linked Immunosorbent Assay IHC: Immunohistochemistry IP: Immunprecipitation WB: Western blot
When staining formalin-fi xed paraffi n-embedded endometrial tissue from the late secretory phase, staining is re-stricted to the glandular cells.(Cat. No. BTE 001-13, anti PP-14)
8
Atrazine ELISA HYB 225-01
beta2-Microglobulin (caiman) WB KSK 003-01
beta2-Microglobulin (human) ELISA, AP HYB 290-03
Biotin ELISA, WB HYB 212-01
Butyrylcholinesterase (human, BtChE) ELISA (matched pair) HAH 002-01*
Chloroquine ELISA HYB 317-01
Chorionic gonadotrophin (human, hCG) ELISA, WB >1 clone
Clostridium botulinum E toxoid (Botulin E toxoid) ELISA HAV 001-06
Clostridium tetani toxoid (Tetanus toxoid) ELISA >1 clone
Collagen Type I (human, bovine, pig, sheep, dog, goat) ELISA, WB, IHC CSI 008-01
Collagen Type III (human, dog, rat, kangaroo) ELISA, WB, IHC CSI 007-01
Collagen Type V (human, dog, sheep, pig, kangaroo, rabbit, bovine) ELISA, WB, IHC CSI 006-01
Collectin-43 (bovine, CL-43) ELISA, WB >1 clone
Complement component C1-inhibitor (C1-INH) ELISA >1 clone
Complement component C1s (human, pro- and activated enzyme) ELISA >1 clone
Complement component C2 (human) ELISA, WB >1 clone
Complement component C3 (human) ELISA, WB >1 clone
Complement component C3 (human), beta-chain genetic variant ELISA, WB HAV 004-01
Complement component C3 (rat) ELISA, IHC HYB 118-02
Complement component C3a/C3a desArg (human) ELISA (matched pair), WB >1 clone*
Complement component C4 (human) ELISA, WB >1 clone
Complement component C5 (human) ELISA, WB >1 clone
Complement component C5a/C5a(desArg) anaphylatoxin (human) ELISA, WB GAU 025-05
Complement component C5b-9 ELISA, IHC DIA 011-01*
Complement component C9 (human) ELISA, WB >1 clone
Complement factor B (human) ELISA, WB >1 clone*
Complement factor D (human) ELISA (matched pair), WB >1 clone*
Complement factor H (human, β1H-globulin) ELISA (matched pair), WB >1 clone*
Complement factor I (human) ELISA, WB >1 clone
Conglutinin (bovine) ELISA HYB 263-02
Corynebacterium diphtheriae toxoid (Diphtheria toxoid) ELISA (matched pair), WB >1 clone*
D-dimer (human, dog) ELISA (matched pair) >1 clone*
Estradiol-17-beta ELISA HYB 057-02
Exendin-4 ELISA (matched pair) >1 clone*
Factor IX (human, Christmas factor) ELISA, WB >1 clone
Fibrinogen (human) ELISA, WB >1 clone
Fibronectin (bovine) ELISA, WB, IHC, IP CSI 005-22
Fibronectin (bovine, human) ELISA, WB, IHC, IP >1 clone
Fibronectin (bovine, human, chicken) ELISA, WB, IHC, IP CSI 005-17
Fibronectin (human) ELISA, WB HYB 051-05
Specificity Application Cat. No.
9
Gastric Inhibitory Polypeptide (GIP) ELISA, IHC >1 clone
Gc-globulin (Vitamin-D binding protein, human) ELISA (matched pair), WB >1 clone*
Gelsolin (human) ELISA, WB ABS 017-20
Ghrelin (human) ELISA (matched pair) ABS 050-45
Ghrelin (human, rat) ELISA ABS 052-121*
Gliadin peptide ELISA, WB >1 clone
Glucagon-like peptide-1 (GLP-1(1-36)amide, N-terminal-extension specific)
ELISA HYB 011-05
Glucagon-like peptide-1 (GLP-1(7-36)amide, C-terminal specific) ELISA (matched pair), IHC HYB 147-06*
Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)
ELISA, IHC >1 clone*
Glucagon-like peptide-1 (GLP-1, Mid-molecule specific) ELISA, WB, IHC >1 clone*
Glucagon-like peptide-1 (GLP-1, Non-amidated (-Arg-Gly), C-termi-nal specific)
ELISA (matched pair) ABS 046-03*
Glucagon-like peptide-2 (human, GLP-2) ELISA HYB 006-02
Glucagon (human, pig, rat) ELISA (matched pair) >1 clone*
Glycoprotein-340 (human, gp-340) ELISA, WB, IHC >1 clone
Haptoglobulin (human) ELISA HYB 170-06
Hemopexin (human) ELISA (matched pair) >1 clone*
H-Ficolin (human) ELISA (matched pair) RIG 334-01*
Hirudin ELISA, WB >1 clone
Immunoglobulin light chain (rat, kappa chain) ELISA, AC MARK 1
Influenza A virus nucleoprotein ELISA (matched pair), WB HYB 156-01*
Influenza B virus nucleoprotein ELISA (matched pair), WB >1 clone*
Leptin ELISA (matched pair), IHC >1 clone*
L-Ficolin (human) ELISA, WB >1 clone
Mannan-binding lectin (chicken, MBL) ELISA, WB, IHC HYB 182-01
Mannan-binding lectin (human, horse, pig, MBL) ELISA HYB 131-14
Mannan-binding lectin (human, MBL) ELISA (matched pair), WB, IHC >1 clone*
Mannan-binding lectin (rat, MBL) ELISA HYB 131-18
MDA-treated low-density lipoprotein (human, LDL) ELISA, WB >1 clone
M-Ficolin (human) ELISA, IHC >1 clone
Mycobacterium tuberculosis Ag85 ELISA, WB HYT 27-1
Mycobacterium tuberculosis, ESAT-6 ELISA, WB HYB 076-08
Mycobacterium tuberculosis, L-alanine dehydrogenase (Ald) ELISA, WB HBT 10-1
Neuropeptide Y (human, rat, mouse, NPY) ELISA, IHC ABS 028-08
Neutrophil gelatinase-associated lipocalin (dog, NGAL) ELISA (matched pair), WB >1 clone*
Neutrophil gelatinase-associated lipocalin (human, NGAL) ELISA (matched pair), WB, IHC >1 clone*
Neutrophil gelatinase-associated lipocalin (monkey, NGAL) ELISA (matched pair), IHC >1 clone*
Neutrophil gelatinase-associated lipocalin (mouse, NGAL) ELISA (matched pair), WB, IHC >1 clone*
Neutrophil gelatinase-associated lipocalin (pig, NGAL) ELISA (matched pair), WB, IHC >1 clone*
Specificity Application Cat. No.
10
Neutrophil gelatinase-associated lipocalin (rat, NGAL) ELISA (matched pair), WB, IHC >1 clone*
Ovalbumin (chicken) ELISA, IP >1 clone
Ovalbumin (chicken, denatured) ELISA, WB >1 clone
Pancreatic Polypeptide (human, PP) ELISA ABS 030-06
Peptide Histidine-Methionine (PHM) ELISA ABS 020-03
Peptide YY (human, PYY (3-36)(peptide tyrosine-tyrosine amide, 3-36))
ELISA (matched pair) ABS 051-04
Peptide YY (human, PYY) ELISA, IHC ABS 029-01*
Perlecan (bovine) ELISA, IHC, IP, AC, WB >1 clone
Placental protein 14 (human, PP14, glycodelin A) ELISA, IHC >1 clone
Plasminogen activator inhibitor type I (human, PAI-1) ELISA, WB, IHC, AP >1 clone
Pneumolysin ELISA, WB HYB 041-01
Poliovirus type 1 ELISA >1 clone
Poliovirus type 2 ELISA >1 clone
Poliovirus type 3 ELISA >1 clone
Pregnancy-associated plasma protein A (human, PAPP-A) ELISA (matched pair), IHC >1 clone*
Procollagen type I C-terminal propeptide (human, PICP) ELISA >1 clone
Procollagen type IIA N-terminal propeptide (human, PIIANP) ELISA, IHC BTE 003-02
Properdin (human) ELISA (matched pair), WB >1 clone*
Protein C (human) ELISA, WB, IHC >1 clone
Protein S (human) ELISA HYB 232-11
Streptolysin ELISA HAB 003
Surfactant protein A (human, hSP-A) ELISA, WB, IHC HYB 238-04*
Surfactant protein D (human, hSP-D) ELISA, WB, IHC >1 clone*
Tetranectin (human) ELISA (matched pair), WB, IHC >1 clone
Thrombin (human) ELISA, WB >1 clone
Thrombospondin I (bovine) ELISA, IHC, IP CSI 002-65
Tissue plasminogen activator (human, tPA) ELISA, WB, IHC MON T-1
Trypsin (human) ELISA (matched pair), WB >1 clone*
Tumor necrosis factor alpha (human, TNF-alpha) ELISA >1 clone
Urokinase plasminogen activator (human, uPA) ELISA, WB, IHC, FC >1 clone
Urokinase plasminogen activator receptor (human, uPAR) ELISA, WB, IHC, FC >1 clone
Vasoactive Intestinal Peptide (human, bovine, porcine, rat, VIP) ELISA ABS 023-02
Vitronectin (bovine, horse, rabbit) ELISA, IHC CSI 004-18
Vitronectin (bovine, sheep) ELISA, WB, IHC, AP CSI 004-27
Vitronectin (human) ELISA, WB, IHC >1 clone
Vitronectin (human, dog, cat, rabbit, bovine) ELISA, WB CSI 003-21
Vitronectin (human, dog, cat, sheep) ELISA, WB CSI 003-08
von Willebrand factor (human, vWf) ELISA >1 clone
Specificity Application Cat. No.
11
Human monoclonal IgE (non-immune antibody)
The DIA HE1 IgE preparation is an affinity-purified, fully human IgE antibody with kappa light chains. The IgE is produced in vitro from a monoclonal hybridoma. This unique source guarantees freedom from contamination by other immunoglobulin iso-types.
Compared to IgE from a myeloma patient, where batch-to-batch variability may be high, the monoclonal source of IgE ensures very high reproducibility. Because of its very low batch-to-batch variation, this antibody is used widely in the field of allergy testing mostly as a standard in quantitative IgE assays and for internal control and QC purposes.
Other applications include research in immunochemistry and in cellular immunology.
Antigenes and SeraSpecificity Application Cat. No.
IgE human (non-immune), without azide ELISA, WB, cell stimulation assays DIA HE1
IgE human (non-immune), with azide ELISA, WB DIA HE1A*
MBL standard serum (human) - 1000 (AU) ELISA, WB SER 101
MBL oligomer deficient serum, B/C genotype (human) ELISA, WB SER 103
NGAL (monomer) recombinant human ELISA SP001RA
NGAL recombinant mouse ELISA SP002RA
NGAL recombinant rat ELISA SP003RA
NGAL recombinant dog ELISA SP004RA
NGAL recombinant pig ELISA SP005RA
NGAL recombinant monkey ELISA SP006RA
195
142
96
71
48
33
28
22
1 2 3
Lane 1: shows molecular weight markers.
Lane 2: DIA HE1 purified human IgE, 185 kDa.
Lane 3: IgE, purified from serum from a myeloma patient.Only
commercially available human monoclonal IgE
antibody
SDS-PAGE (16%)
12Diagnostics
Acute Kidney injury (AKI)
Acute kidney injury (AKI), previously known as acute renal failure, represents a medi-cal emergency and encompasses a wide range of injury to the kidneys. Acute kidney injury is a rapid deterioration of renal function, resulting in an inability to maintain fl uid, electrolyte and acid-base balance. Acute kidney injury increase morbidity and mortal-ity and due to the severity of acute kidney injury the healthcare costs are signifi cant. As a result of this increased efforts into identifying new acute kidney injury biomarkers can be seen, as biomarkers addressing the need for earlier diagnosis of acute kidney injury would ultimately save lives, raise quality of life for patients worldwide and save costs for the healthcare system.
The NGAL Test™ is a particle-enhanced turbidimetric immunoassay for the quan-titative determination of neutrophil gelatinase-associated lipocalin (NGAL) in human urine, EDTA plasma or heparin plasma on automated clinical chemistry analyzers. NGAL measurements are useful in the diagnosis of acute kidney injury which may lead to acute renal failure. The test can be run on most automated clinical chemistry analyzers.
Measuring NGAL in urine or plasma gives you information on AKI status that you need for rapid decision making e.g. in the following settings -
» Renal transplantation - predictive evaluation » Cardiopulmonary bypass surgey - monitoring » Emergency room - triage tool » Intensive care - monitoring » Intravenous contrast agents - assessing nephrotoxicity
The NGAL Test™ – fi rst diagnostic acute kidney injury biomarker which can be measured in both human urine and plasma
NGAL – Bridging the tox gap in nephrotoxicity research
By ensuring strong focus on nephrotoxicity from drug discovery and development over to human clinical trials the success rate and correct decision making on new compounds may increase. Bio-Porto Diagnostics have developed and launched a market leading range of animal NGAL antibodies and ELISA kits (mouse, rat, dog, pig and monkey) as well as human, which enables thorough re-search on renal toxicity in all phases of drug development.
Feature: NGAL (neutrophil gelatinase-associated lipocalin)
13
Through dedicated research BioPorto offers the world’s leading portfolio of commercially available antibodies against GLP-1.
Peptide hormonesProtein/peptide hormones are typically generated as pro-hor-mones that are secreted into the circulatory system following spe-cific stimuli. Once secreted, most peptide hormones exist free in the circulation.
While traversing the circulation, peptide hormones encounter receptors on the surface of target cells and bind to cell surface receptors on specialized endocrine cells. The endocrine cells synthesize, store and secrete the protein/peptide hormones and hereby activate a variety of signal transduction systems.
BioPorto Diagnostics peptide hormone antibodies
BioPorto’s GLP-1 antibodiesWe have selected our GLP-1 antibodies on the basis of the dif-ferent ways in which they bind to the GLP-1 molecule. Some bind sideways to both active and inactive forms of the molecule, and some bind end-on, exclusively to the biologically active forms.
BioPorto’s antibodies are used in different combinations with themselves to analyze different forms of GLP-1 during the devel-opment and testing of GLP-1-related treatments. This may be in early development phases and clinical phase I and/or in process and quality control of therapeutic products.
Glucagon-like peptide-1 (C-terminal amidated)
HYB 011-05 HYB 147-06 ABS 046-03
C-terminus C-terminusN-terminal extension
N-terminus
36 amide
1 6 7
36 amide
7
36 amide
37
37
379
HYB 147-08HYB 147-12HYB 147-13
ABS 033-04ABS 033-10
ABS 044-49ABS 044-53
1
2
3
GLP-1 Extended form GLP-1 Active form GLP-1 Metabolite
HYB 011-05 HYB 147-06
C-terminusN-terminal extension
N-terminus
36(amide)1 6 7
36(amide)7
36(amide)9
HYB 147-08HYB 147-12HYB 147-13
ABS 033-04ABS 033-10
1
2
3
HYB 011-05 HYB 147-06
C-terminusN-terminal extension
N-terminus
36(amide)1 6 7
36(amide)7
36(amide)9
HYB 147-08HYB 147-12HYB 147-13
ABS 033-04ABS 033-10
1
2
3
HYB 011-05 HYB 147-06
C-terminusN-terminal extension
N-terminus
36(amide)1 6 7
36(amide)7
36(amide)9
HYB 147-08HYB 147-12HYB 147-13
ABS 033-04ABS 033-10
1
2
3
Feature: Peptide hormones
Specificity
α-CRGP (calcitonin gene-related peptide, human)
Adrenomedullin (human)
Exendin-4
Gastric inhibitory polypeptide (human, hGIP)
GLP-1
Glucagon-like peptide-2 (human, hGLP-2)
Glucagon (human, pig, rat)
Specificity
Leptin (human)
Neuropeptide Y (human, rat, NPY)
Pancreatic Polypeptide (human, PP)
Peptide histidine-methionine (human, PHM)
Peptide YY (human, PYY)
Vasoactive Interstinal Peptide (human, bovine, porcine, rat, VIP)
14
Through dedicated research BioPorto offers a market leading range of high quality antibodies covering all pathways in the complement cascade.
Overview of the complement system. The name of the component and BioPorto Diagnostics' catalog number are shown in the blue boxes.
MBLKIT 029HYB 131
C1-INHHYB 288
C1sABS 002
C2HYB 050
C3HAV 004HYB 005
C3dHAV 003HYB 030
HYB 029
C9ABS 004
DIA 011
Factor BHAV 005
Factor DGAU 010GAU 00
M-FicolinABS 036
H-FicolinRIG 334
L-FicolinABS 005
8
Factor Ba/bHYB 008
ProperdinHYB 0393
C4HYB 162-04
C4bHYB 162-02
Factor HHYB 268GAU 018GAU 020
C3a/C3a (desArg)GAU 013GAU 017
Factor IHYB 061
Lysis or phagocytosis of the microorganism
C5 - C9Membrane attack complex
C3bBb
C3a
C3bBb3b
C1q
C1rC1s
C2b C4a
C4
C4bC2aC4b2a
C3
C3a
C4b2a3b
C1q
Classical Pathway Lectin Pathway Alternative Pathway
MBL/Ficolin
MASP-2
Carbohydrate
C2
Carbohydrate
MASP-1
C5b-9
C5
C5a/C5a (desArg)GAU 025
C3
C3 (H2O)D
B
BaC3 (H2O) Bb
C3a
C3 (H2O) B
H2O
Properdin (Factor P)
Feature: Complement
It forms part of the innate immune system and the complement system is made up of a large number of distinct plasma proteins that react with one another to opsonize pathogens and induce a series of infl ammatory responses that help to fi ght infection.
An important factor in the innate immunity system is Mannan-binding lectin (MBL). Compared to other defi ciencies in the complement system the incidenceof MBL defi ciency is high – and low levels of MBL are associated with increased risk of infection in toddlers. BioPorto offers the unique sandwich ELISA assay, which is the only assay build with the widely used MBL antibody (HYB 131-01). More than 100 scientifi c references are using this assay and BioPorto is offering this as the MBL Oligomer ELISA Kit solution for measuring functional MBL in patients with primary immune defi ciencies (PID).
The complement system
Our range of antibodies covers all 3 main complement
pathways in the complement cascade:
Classical pathwayAlternative pathway
Lectin pathway
15
At BioPorto Diagnostics we see opportunities
as we wish to take an active part in shaping the future of health care
BioPorto Diagnostics have through dedicated
and focused efforts been able to market unique
and high quality antibodies supporting basic
research as well as being key components
in the development of assays for diagnostic
usage. Antibodies from BioPorto are powerful
tools in both areas as they are developed with
unique specificity.
Diagnostics
CIENTISOL, S.L.U.T. 981 936 338www.cientisol.com · [email protected]