PRODUCT CATALOG - MBL

International Corporationlife. science.discovery.™

PRODUCT CATALOG

Immunof luorescenceAssays for Autoimmuneand Infectious Disease

International Corporation

COMPANYMBL Bion, part of the MBL International Corporation, has been manufacturing high-quality kits and components for autoimmune, infectious, and viral diagnostics for more than 30 years. By focusing specifi cally on immunofl uorescence assays, MBL Bion is unmatched in providing lot-to-lot consistency and technical expertise to laboratories around the world.

Located in Des Plaines, IL, MBL Bion is FDA registered and ISO 13485:2003 certifi ed with research and development, manufacturing, and administration operating from one facility. The vertically integrated operation improves product development and manufacturing effi ciencies as well as an enhanced customer experience.

Our customer service, technical support, and commercial teams are dedicated to providing world-class support whether addressing your specifi c product questions or to ensure effi cient and accurate ordering. By providing products in convenient, user-friendly or customized formats, MBL Bion offers a wide product portfolio to meet your testing needs.

COMPANY


TABLE OF CONTENTS

Autoimmune IFA Products

• ANA Test Systems 3

• ANA Substrate Slides & Control Sera 4

• Components & Conjugates 5

Infectious Disease IFA Products

• Test Systems 7

• Special Antigen Substrate Slides 8

• Viral Antigen Substrate Slides 9

• Control Sera 13

• Antigen Control Slides 14

• Components & Conjugates 15

Ordering Information 16

TABLE OF CONTENTS

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Autoimmune IFA Products

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ANA TEST SYSTEMSAntinuclear antibodies (ANA’s) are a group of autoantibodies characterized by specifi city for numerous antigenic determinants of cell nuclei. ANA’s have been proven to be very useful as disease markers, primarily for diagnostic screening and also to monitor the course of connective tissue diseases.

Why Use IFA?The immunoflourescence ANA test is the preferred method for ANA testing. Since 2009, The American College of Rheumatology has recom-mended that the immunofl ourescence ANA test should remain the gold standard for ANA testing*.

The indirect fl uorescent antibody (IFA) test is sensitive, screens for a wide variety of known and unknown autoantibodies and through pattern recognition offers insights into the probable identity of the antigen and associated autoimmune disorder. The MBL Bion ANA (Anti-Nuclear Antibody) Test System is an indirect fl uorescent antibody assay utilizing HEp-2 tissue culture cells as a substrate for the qualitative and/or semiquantitative determination of antinuclear antibodies in human serum. The MBL Bion ANA Test System is intended for use as an aid in the diagnosis of certain autoimmune diseases.

ANA TEST SYSTEMS

*American College of Rheumatology, Position Statement on the Methodology of Testing for Antinuclear Antibodies Diseases. Available at: http://www.rheumatology.org/practice/clinical/position/ana_position_stmt.pdf

Kit Confi gurations

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ANA SUBSTRATE SLIDESThe antigen of the MBL Bion ANA substrate is a human epithelial cell (HEp-2) line. HEp-2 cells have been shown to have greater sensitivity than tissue sections and aid in sharper differential pattern recognition as well as detecting previously unreported nuclear antibodies.

• Each lot is tested with a panel of titered control sera to ensure sensitivity from lot to lot • Each lot is tested for pattern types, and for specifi c antinuclear antibodies • Mitotic cells are present for detection of centromere antibodies; also helps to identify other patterns • Substrate is sensitive for detection of low titered specifi c antibodies • Substrate is specifi c for detection of SS-A and other antibodies

ANA SUBSTRATE SLIDES & CONTROL SERA

ANA CONTROL SERAPositive Control Sera are prepared to give a 2+ to 4+ fl uorescence when used as supplied (undiluted) in MBL Bion’s Immunofl uorescent Test Systems. Negative Control Sera are prepared to give less than a 1+ fl uorescence when used as supplied (undiluted) in MBL Bion’s Immunofl uorescent Test Systems.

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ANA COMPONENTS & CONJUGATESFluorescent AntibodyConjugatesReady to use dropper bottle of fl uorescein isothiocyanate (FITC) labeled goat anti-human IgG (heavy and light chain specifi c) to detect IgG, IgA and IgM with Evans Blue counterstain, protein stabilizer, less than than 0.1% sodium azide and 0.001% thimerosal. Available in convenient volume sizes.

ANA COMPONENTS AND CONJUGATES

IFA DiluentIFA Diluent is intended to reduce the nonspecifi c fl uorescence associated with some serum specimens, and thereby improves the readability of these specimens without affecting the endpoint titers of specifi c immunofl uorescent reactions. It is strongly recommended that IFA Diluent be used to prepare the screening dilution of the serum sample for use in MBL Bion’s Antinuclear Antibody Test System.

Phosphate Buffered Saline (PBS)Dry packets to make one liter or fi ve liters of PBS.

Mounting MediumDropper bottle containing phosphate buffered glycerol of pH 7.4 ± 0.2.

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Infectious Disease IFA products

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INFECTIOUS DISEASE TEST SYSTEMS

INFECTIOUS DISEASE TEST SYSTEMSMBL Bion Infectious Disease IFA Test Systems are indirect fl uorescent antibody assays for the qualitative and/or semi-quantitative determination of specifi c infectious disease antibodies in human serum. They are intended for use as an aid in the diagnosis of primary infection, re-infection or reactivation of the latent virus as well as a determination of immunological experience and/or immune status.

Kit Confi gurations

7


SPECIAL ANTIGEN SUBSTRATE SLIDES

SPECIAL ANTIGEN SUBSTRATE SLIDES • Each lot is tested with a panel of titered sera to ensure sensitivity lot to lot • Most substrates can be used for the detection of IgG or IgM antibodies • Chlamydia substrate has both Inclusions and Elementary Bodies • Mycoplasma substrate consists of cells with microorganisms and colonies

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VIRAL ANTIGEN SUBSTRATE SLIDES

VIRAL ANTIGEN SUBSTRATE SLIDES • Each lot is tested with a panel of titered sera to ensure sensitivity lot to lot. • Both Positive and Negative cells are in each well to provide a built-in control. • Most substrates can be used for the detection of IgG or IgM antibodies.

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CONTROL SERA

CONTROL SERAPositive Control SerumVial containing 0.5 mL positive IgG or positive IgM human control serum with protein stabilizer and 0.005% thimerosal and is prepared to give a 2+ or greater fl uorescence when used as supplied (undiluted) in the MBL Bion Immunofl uorescent Test Systems. IgM Controls sold when available.

Negative Control SerumVial containing 0.5 mL negative human control serum with protein stabilizer and 0.005% thimerosal and is prepared to give less than a 1+ fl uorescence when used as supplied (undiluted) in the MBL Bion Immunofl uorescent Test Systems.

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ANTIGEN CONTROL SLIDES

ANTIGEN CONTROL SLIDESDirect identifi cation control slides are designed to be used as quality control substrates for staining reagents (i.e. monoclonal antibodies) that are used in direct antigen detection and culture confi rmation methodologies. Each slide consists of a well(s) containing the antigen infected tissue culture cells (positive control) and a well(s) containing the infected tissue culture cells (negative control).

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IFA COMPONENTS & CONJUGATES

IFA COMPONENTS & CONJUGATES Fluorescent Antibody ConjugatesReady to use dropper bottle of fl uorescent isothiocyanate (FITC) labeled goat anti-human IgG or IGM (heavy chain specifi c) with Evans Blue counterstain, protein stabilizer, less than 0.1% sodium azide and 0.001% thimerosal. Available in convenient volume sizes.

Phosphate Buffered Saline (PBS)Dry packets to make one liter or fi ve liters of PBS.

Mounting MediumDropper bottle containing phosphate buffered glycerol of pH 7.4 ± 0.2.

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ORDERING INFORMATION

Please provide the following information to expedite your telephone, fax or mailed orders.

1) Purchase Order Number or valid credit card (Visa, MasterCard, American Express) 2) Your name, telephone, fax number, and email address. Please include Customer Account Number on the attention line 3) End User’s name, telephone number, and email address 4) Ship To and Bill To addresses 5) Product Catalog Number and description 6) Quantity and product size 7) Minimum order $25.00

By phone: 1-847-544-5044 (8:30AM to 6:00PM EST, Monday through Friday) By fax: 847-544-5051 By mail: MBL International 455 State Street, Suite 100 Des Plaines, IL 60016-2204

If you have any questions about an order, you can reach us by email via [email protected]

Technical SupportFor technical assistance you may reach us via email at [email protected] or by telephone at 847-544-5044.

Shipping All orders received by 3:00 PM(EST) Monday through Thursday are routinely shipped the same day and delivered the next day via overnight service. Domestic orders received after 3:00 PM on Thursday cannot be shipped until the following Monday. Prepaid overnight delivery charges will be added to the invoice. International shipments will have different freight charges and transit times. If any item you have ordered is temporarily out of stock, you will be notifi ed when that item will be available for shipment. All shipments are F.O.B Des Plaines, IL.

Payment Terms Payment terms are net 30 days from the invoice date. All prices quoted are in U.S. dollars. Prices are subject to change without notice. For customer convenience, MBL Bion will accept VISA, Master Card and American Express for purchases. Credit card approval must be obtained prior to shipment.


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Quoted PricesAll requests for quotations should be directed to our Sales Department at 1-800-200-5459 ext. 1 or by email at [email protected]. Quoted prices do not include shipping, handling or taxes.

Volume DiscountsThe extended life of MBL Bion slides allows our customers to take advantage of our volume discount offers. Volume discounts are available.

Standing OrdersMBL Bion will schedule periodic shipments of any product to assure uniform customer inventory and to reduce order processing. Specifi c arrangements regarding product, quantity and shipping dates must be made in advance.

WarrantiesMBL Bion guarantees the material to be of merchantable quality at the time of shipment. Our liability is limited only to replacement of products up to the amount of the purchase price. MBL Bion makes no other warranty, expressed or implied, including any implied warranty of fi tness for a particular purpose or of merchantability. In no case shall MBL Bion assume any responsibility for the use or handling of the product or any liability for consequential, special, indirect, or incidental damages resulting there from. Note: We guarantee our products to perform satisfactorily for the use they are intended if stored as directed and used before the expiration date.

Returns No products will be accepted for return, credit or replacement without prior authorization from an MBL Bion team member. All returns are subject to a 25% restocking charge. No product may be returned for credit after 7 days from receipt of the product.


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www.mblintl.com

MBL Bion

455 State Street

Suite 100

Des Plaines, IL 60016-2204

MBL Bion

455 State Street

Suite 100

Des Plaines, IL 60016-2204


MBL International

15A Constitution Way

Woburn, MA 01801

PRODUCT CATALOG - MBL

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