Problem reaction - solution
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PROBLEM – REACTION - SOLUTION
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Chronic diseases are often connected to anaemia.
There is a large number of chronics in various diseases with iron deficiency.
These are for instance Chronic kidney disease, Inflammatory bowel disease or Coronary heart disease patients and many others.
PROBLEM
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Iron-deficient chronic primary therapy is normally oral iron in tablet form, which is non-heme iron where the iron is syntethically bound.
The main forms used are iron salts Ferrous sulphate and Ferrous fumarate, Amino acids chelates, Carbonyl iron and Polysaccharide-iron complexes.
PROBLEM
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Non-heme iron needs to disintegrate in the stomach's acidic environment before the iron ions can be absorbed.
If there is a acid-lowering achlorhydria therapy going on such as Omeprazole, which is often the case, this won’t happen and no iron will be absorbed.
PROBLEM
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Free iron ions are basically toxic for the organism, so after breaking down of non-heme iron there will be free iron ions in the stomach.
This gives the typical side-effects problems with oral iron. Absorption of non-heme iron is low, 2 – 4 %.
PROBLEM
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Sooner or later the oral non-heme therapy will give increasing side-effects, so that the therapy must be discontinued.
If serious and chronic iron deficiency is present for any reason, it must be treated, or life-threatening anemia will occur.
REACTION
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The only remaining therapy alternative is IV-, or intravenous iron.
This is administered in daily more or less painful injections.
REACTION
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Intravenous or IV-iron, however, also has drawbacks.
There is a risk for allergic reactions and the main risk is oxidative stress, since this is not a natural way to absorb iron.
It is also very expensive.
REACTION
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As opposed to non-heme iron, natural hemoglobin is absorbed as a whole unit,
Heme iron supplementation works well over longer time.
Efficacy, tolerance or uptake will not change over time and there are very few side-effects.
SOLUTION
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Dosage of heme iron tablets once per day is very user-friendly.
Heme iron dosage does not need medical assistance, thus freeing the patient to for instance travel.
SOLUTION
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Uptake of heme iron is 15 – 25 %, which is several times that of oral non-heme.
In studies side-effects are at placebo-level.
Heme iron is reasonably priced.
SOLUTION
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Swedish company FerroCare/MediTec has a strong commitment to reach
people suffering from iron deficiency, but have problems with
existing supplements.
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• OptiFer® tablets are based on natural bovine heme iron and will safely and efficiently keep iron counts at an optimal level.
www.ferrocare.se www.hemeiron.com