Scientific evidence reinforcing the importance of key whole foodnutrients in maximizing health, vitality and longevity, continues tomount. The nutrients contained in fruits, vegetables, whole grainsand fish are so strongly connected to preserving health andwellness, that authorities worldwide urge us to increase ourconsumption of these foods as the primary tool in the battle againstchronic disease.

Here are three recent studies from major research centers publishedin leading peer-reviewed scientific journals that affirm this message:

• Too much of the wrong foods sets a course for disease…A study published in the August 15, 2007 issue of the Journal ofthe American Medical Association (JAMA) calls attention to thesevere health risks associated with our Western diet, grosslydeficient in whole-food nutrients from fruits, vegetables, grainsand fish, but excessive in processed fats, carbohydrates andcalories. While evaluating colorectal cancer recurrence,researchers from the Dana-Farber Cancer Institute in Bostondemonstrated that 80% of all colorectal cancer cases were bothdirectly or indirectly attributable to the Western industrialized-eating habit and preventable with dietary change. Theirrecommendations for reducing this risk: a prudent diet rich infruits, vegetables, poultry and fish.1

• Getting an abundance of the right foods is the pathto long-term health!

Published in the July 2007 issue of the American Journal ofClinical Nutrition, researchers from Monash University and theCancer Council of Victoria, The University of Melbourne, theUniversity of Cambridge and St. Vincent’s Hospital Melbournereport that, “This combination [of fruit, vegetable, and omega-3dietary content] is believed to have antioxidant, anti-inflammatoryand anti-thrombotic properties that reduce the risk ofcardiovascular disease by 30%”. These nutrients have also beenshown to lower the rate of incidence for obesity and variouscancers.2 Evidence demonstrating the health benefits associatedwith these foods was also described by a study conducted at theHarvard School of Public Health in 2007 suggesting that higherintakes of antioxidant and anti-inflammatory micronutrients areassociated with lower reports of cough, respiratory infections andless severe asthma-related symptoms.3

• Much is lost to industrialized growing and processing!According to a research from Wageningen University in Hollandpublished in the November 2005 issue of the Journal of Food

Chemistry, nearly every phase of processing from “farm-to-fork”reduced the level of the healthy phytonutrients in fruits and vegetables.4

Data presented by researchers from the Department of SoilSciences at the University of Wisconsin – Madison confirms thatwhile great advances in crop yield have occurred in the last 50years, nutrient content has been under siege and declining5. Asimilar review of data published by the USDA’s ARS Nutrient DataLaboratory (chart 1) shows “a sharp decline in the minerals infoods since the last comprehensive survey [nearly 20 years ago]”

Modern industrialized diets are directly linked to disease.The diet that has dominated the industrial world for the last fewdecades is directly related to the epidemic of chronic disease6.Foods consumed by the average human today are not only energy-dense and nutrient-deficient, but also lack the nutritional diversityfundamental to healthy human biochemistry. Overflowing withprocessed fats, carbohydrates and chemicals alien to the humanfood chain, the modern-day diet leaves us overfed, under-nourishedand needlessly exposed to vitality-robbing health problems.

Whole food supplementation: A strategy that works.Changing our diets is not an easy or convenient transition forsomeone living in the quick pace of the modern industrializedworld. But we know that nutritional supplementation that is well-formulated and derived from whole-food sources actually foundin the human food chain can fill in the gaps left by the modernindustrialized diet. It supports our body in producing energy, andpromoting vitality and long life.

Pro Vitality Nutrition: The Evidence Continues to Build

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Tre-en-en Grain ConcentratesFeed your cells

Background: We first discovered the important role lipids play asbuilding blocks for our cell membranes in 192513. By the 1950’sresearchers realized that the cell membrane not only served as amechanism to separate the inside of the cell from the outside, butalso functioned as a highly selective filter that facilitated transportsystems controlling nutrient entry and waste removal14. From thatpoint, we began to recognize the importance of specific lipids inmembrane function, energy production and metabolite secretion(biochemicals manufactured in cells; i.e.; hormones, enzymes)15.

GNLD Research: In the mid-1950s, a group of Southern Californiadoctors investigating the possible causes of patient-reported‘chronic fatigue’ drew a connection between the absence of wholegrain dietary lipids and reduced cellular energy production. Thisresearch led to the concept of lipid supplementation made fromwhole grain wheat, rice and soy, as a solution to ‘chronic fatigue’. This gave rise to GNLD’s Tre-en-en Grain Concentrates. In theyears that followed, Tre-en-en’s beneficial effects on cellmembrane structure and function were further confirmed. Themost compelling demonstration of the positive effects of the lipidsand sterols in Tre-en-en Grain Concentrates was in a studyconducted at Texas A & M University in 1987. This studycompared the effects of Tre-en-en use in the test group to a controlgroup. The results (see charts 2-4) were dramatic16.

Latest Findings: The significance of the key role whole grainlipids and sterols play in cellular structure and function, and inhuman health overall, continues to be supported by even morerecent scientific publications and government-funded awarenesscampaigns. A 1998 study of 34,000 women showed whole grainnutrition had a strong cardio-protective effect17. A component ofthe 1999 Nurse’s Health Study (a survey of 75,000 nurses) showedregular whole grain consumption lowered the risk of heart diseaseby 25% and stroke by 36%18. Another study from 2000 publishedin the Journal of the American Medical Association showed nearlya 50% reduction in ischemic stroke risk for people who normallyconsumed whole grain products19. Whole grain nutrients and theimportance of lipids and sterols continue to be a strong focus pointfor nutritional research20. Here are a few more examples: A May 2005 article in Human Nutrition & Metabolism identifiedwhole grain oils, now nearly devoid from the average diet, asanticancer dietary components21.Two studies conducted in 200522,23 demonstrated the uniquebenefits of rice bran oil in cholesterol reduction.A 2007 meta-analysis study (a study of an accumulation ofevidence)24 concluded that the need for whole grain nutrition is soacute in the population that government efforts to promoteawareness should be doubled. The researchers further concludedthat the process of refining grains removed many biologicallyactive agents, including fiber, vitamins, minerals, lipids, sterolsand other compounds. “These biological agents influencecardiovascular risk through effects on glucose metabolism, lipids,lipoproteins, endothelial function, and other mechanisms,potentially accounting for much of the observed benefit of highintake of whole grains” wrote lead author Phillip Mellen of WakeForest University.

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Carotenoid ComplexProtect your cells

Background: Carotenoids first took center-stage as protectornutrients in the mid 1970’s when researchers at the US Departmentof Health and Human Services and the Centers for Disease Controland Prevention (CDC) identified their role in reducing the risk ofdisease25. National Cancer Institute researcher Regina Ziegler wenton to reveal its connection to lung cancer prevention in 198626, andthen showed a lower risk of cancer in those with the highest dietaryintake of fruit and vegetable-derived carotenoids27,28. The NationalHealth and Nutrition Examination Survey (NHANES) and otherstudies at the time found carotenoids also functioned in hearthealth and reduced the risk of heart disease29,30. Proof of benefitsoon expanded to include eye health and visual acuity31 andimmune function32.

GNLD Research: Research conducted on GNLD’s CarotenoidComplex has spanned more than 15 years. It started with the firstever proof of bioavailability of whole food-derived carotenoids33,34.USDA researchers went on to reaffirm its bioavailability and thendemonstrated its cardio-protective35,36 (see chart 6) and cellularprotective powers37. This was followed by two more studiesconducted by the USDA researchers showing CarotenoidComplex’s beneficial effects (see chart 5) on immune capacity38,39.In 2001, GNLD researchers reaffirmed bioavailability across aneven broader spectrum of dietary carotenoids40.

Latest Findings: Evidence supporting the importance of carotenoidintake for health benefits continues to mount. Concern by leadinghealth authorities over insufficient carotenoid consumption hasresulted in campaigns to increase awareness for higher levels ofcarotenoid intake41,42.Heart and cardiovascular health: A 2004 study conducted by ateam at the Harvard Medical School found that men in the topquintile with higher levels of serum carotenoids (including alpha-carotene, beta-carotene, lycopene, lutein, and beta-cryptoxanthin)had a 40% decreased risk of ischemic stroke than those with thelowest serum levels.43 Similarly, a 2008 study of 559 men showedthat increased intake of alpha and beta carotene from carrotsequated to a 17% reduction in risk of cardiovascular (CVD)death.44 Swedish researchers in 2006 correlated consistently lowerlevels of the carotenoids lutein, zeaxanthin, and beta cryptoxanthinwith coronary artery disease occurrence. The healthy controls hadsignificantly higher levels of these carotenoids in their blood45.Prostate health: Since the early nineties, scientific research hasreported a connection between the carotenoid Lycopene andprostate cancer risk reduction. One study showed that Lycopene(from tomatoes) present in the diet 4 to 5 times per week, attributedto a 25% reduction in prostate cancer risk. The 2-year study foundthat an 82% increase in blood Lycopene levels corresponded witha 42% decrease in prostate-specific antigen (PSA) levels46.Immune health: Swedish researchers in 2001 observed higherlevels of natural killer cells (NK cells) in people with higher levelsof these carotenoids, confirming the relationship between dietarycarotenoid intake, immune capacity and health.Vision health: In a 48-week intervention trial, researchers testedLutein supplementation for vision protective-function in patientswith retinitis pigmentosa (RP). They concluded: “Comparing thedevelopment of vision measures against the natural loss expectedto occur over the course of the 48 weeks, most measures showedreduced decline, and these reductions were significant for normalillumination”47.Mental performance: A 2007 French study48 showed a connectionbetween carotenoids and cognitive performance in a healthyelderly population. Study author Tasnime Akbaraly states “In thisstudy, low levels of specific plasma carotenoids (lycopene andzeaxanthin) were associated to poor cognitive functioning in ahighly educated, community-dwelling elderly population”.Inflammatory health: A 2005 UK study by CambridgeUniversity49 researchers showed that study subjects with thehighest (top one third) daily intake of beta-cryptoxanthin had onlyabout one-half the risk of developing polyarthritis than those in thebottom one-third. Researchers commented that even modestincreases in beta-cryptoxanthin intake were associated with asignificantly reduced risk of developing inflammatory disorderssuch as rheumatoid arthritis.T

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DATA SOURCE: EFFECTS OF A CAROTENE DEFICIENT DIET ON MEASURES OF OXIDATIVE

SUSCEPTIBILITY AND SUPEROXIDE DISMUTASE ACTIVITY IN ADULT WOMEN; Free Radical

Biology in Medicine, Vol. 17, No. 6, pp. 537 - 544, 1994.

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Omega-III Salmon Oil PlusBalance & Regulate your cells

Background: Not only are omega-3 fatty acids in general directlytied to heart health, but their individual abilities to lowertriglycerides, increase HDL (good cholesterol), inhibit plaqueformation, stabilize heart rhythm and maintain healthy veins andarteries have highlighted the huge importance of having all eightmembers of the omega-3 fatty acid family50. Researchers wereaware of the benefits of omega-3 fatty acids before they were evenpublicized in the 1970s. In 1936, an epidemiologist studying theInuit in Greenland observed a zero rate of incidence of heart diseasein the population, and first drew connections between heart healthand the presence of these fatty acids in the Inuit diet51,52. In 1980,Danish researchers documented the extent of the health protectingpowers of omega-3 fatty acids by comparing the incidence ofseveral diseases in Danish versus Greenland Inuit populations53.They showed the Danish population had 10 times more cases ofheart attacks, 20 times more cases of Psoriasis, 25 times more casesof asthma, and 9 times more cases of diabetes than the Inuit.

GNLD Research: GNLD introduced Salmon Oil, derived from pure,natural Salmon, as the most biocompatible, whole food, humanfood chain source of omega-3 fatty acids. Throughout the 1980’sand 90’s the SAB followed scientific and technologicaldevelopments in omega-3 supplementation. In the early 2000’s theydirected the development of a unique technology called “moleculardifferentiation” which, for the first time, allowed consistentidentification, quantification and delivery of all eight members ofthe omega-3 fatty acids family in a whole food supplement.Introduced in 2006, Omega-III Salmon Oil Plus set a new standardfor excellence in omega-3 supplementation. Human clinical trialsconducted under the direction of SAB member Dr. Arianna Carughiand presented at the Annual meeting of theFederation of American Societies forExperimental Biology, April 200854, and atthe annual meeting of the AmericanCollege of Nutrition in October 200855,displayed powerful performance across awide range of benefits, including:56

• Rapid bioavailability and assimilation;resulting in increased anti-inflammatorybalance in cell membranes.

• Triglyceride reduction; on average,17% in just 8 weeks.

• Improved omega-3 to omega-6 ratio;lowering indicators of heart disease risk.

• Improved omega-3 index; a 38%increase in this cardio-protectivemeasure.

• Lowered the inflammatory indexby 68%; reducing the tendency towardinflammation and inflammatoryconditions.

Latest Findings: As more is being discovered about their importanceto health, many scientists and researchers have coined the term“master molecules” to describe the power of omega-3 fatty acids.They are fundamental to human biochemistry, and have been provento have an important role in health, vitality and longevity.

Cardiovascular health: In 2005, daily supplementation of omega-3 fatty acids was shown to reduce risk of fatal heart failures in highrisk patients57. In 2006 researchers looked at data from more than340,000 participants and reported a 35% reduction in the risk ofcardiac death, and a 45% reduction in the risk of sudden death forthose who consumed 850 mg of dietary omega-3’s each day58. A2007 study from Japan reported that daily supplementation resultedin a 24% reduction in angina (heart pain) and a 19% reduction innon-fatal coronary events59. That same year researchers from theUniversity of Athens reported that high dietary omega-3 statusequated to healthier more stable heart rhythm60.

Cognitive health: In 2005 researchers at Louisiana StateUniversity (LSU) showed that fish derived omega-3 fatty acid arenot only vital to brain tissue building but exerts a protective effectagainst neuro-degeneration and brain function decline associatedwith Alzheimer’s61. In 2007 researchers published data that showedthat elderly with the highest dietary omega-3 intake hadsignificantly less cognitive decline than those with the lowest62.That same year it was shown that high dietary omega-3 intakeequated to less decline in verbal ability amongst the elderly63. A2008 study from Taiwan showed that 1.8 grams of supplementalOmega-3 fatty acids may improve general clinical function inpatients with mild or moderate Alzheimer’s disease and mildcognitive impairment64.

Vision health: In addition to the impact of omega-3 fatty acids onreducing the risk of Age-related Macular Degeneration (AMD) by

70 per cent65, omega-3 fatty acids, particularlyDHA, have been shown play an importantrole in the layer of nerve cells in the retina.

Pregnancy and lactation: The importance ofomega-3 dietary intake during pregnancy andlactation has been shown in several recentstudies. One recent example from Canadareported that an increased intake of theomega-3 DHA during pregnancy couldproduce improved motor function in theoffspring in later life66.

Bone and Joint health: Confirming previousstudies that omega-3 fatty acids can reduceand even prevent inflammation, A studypublished in the April 2006 issue of thejournal Surgical Neurology showed thatomega-3 supplementation is effective againstback and neck pain67. In 2007, Swedishresearchers showed that young men with thehighest dietary omega-3 fatty acid intake ingeneral; and DHA in particular also amassedthe strongest bones68.

CARDIO RISK

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Chart 7 - Increased Cardio Protection- Decreased Cardio Risk

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Diet and the global health crisis: WHO knew!In their 2005 landmark report entitled “Chronic Disease: A vital Investment”,the World Health Organization (WHO) spotlights the dire state of globalhealth, and sounds the alarm—we are quickly losing this battle. Here is whatthey told us:7

• Chronic Disease (heart disease, cancer, stroke, chronic respiratory disease anddiabetes) kills twice as many people as all infectious disease, includingHIV/AIDS, tuberculosis, malaria, influenza and pneumonia, combined.

• This count is expected to increase 17% by 2015. (Faster than the rate ofpopulation growth.)

• Unhealthy eating is identified as the #1 cause, followed by physical inactivityand tobacco use.

Strategy for prevention:

1: FIX YOUR DIET 2: GET ACTIVE 3: IF YOU SMOKE, QUIT

The first step in preventing chronic disease is changing our diet.Here is what the WHO and other global health authoritieshave to recommend:

Heart disease: Heart disease is the #1 killer, accounting fornearly one-third of all deaths world-wide. WHO’s nutritionalstrategy for prevention: Increase intake of fish, fruits,vegetables, nuts and whole grains; maintain a healthy weight.Likewise the American Heart Association’s8 nutritional keysfor heart health: eat more fruits, vegetable, whole grains andfish rich in Omega-3 Fatty Acids.

Cancer: 20 million people suffered with cancer in 2005. WHOprojects a 50% increase in new cases of cancer in just 15years. They found that dietary factors accounted for about30% of cancers cases. To reduce the risk of cancer, WHOalong with The US Centers for Disease Control andPrevention (CDC) and the US National Cancer Institute (NCI)recommend: Eat more fruits, vegetables and whole grains.

And of course, if you smoke, quit.9 The NCI in particular drawsspecific attention to the phyto-nutrient family of carotenoids,highlighting their role in cancer prevention.10

Diabetes: Diabetes is quickly becoming a global epidemic...171,000,000 people suffered from it in 2005. And it isprojected to grow to 366,000,000 by 2030... a 114% increase!In fact, many medical researchers now believe that for everyperson diagnosed with diabetes, there will be two moreindividuals in a state of ‘pre-diabetes’, resulting in more than1,000,000,000 diabetic sufferers around the world.

The nutritional strategy for prevention according to theAmerican Diabetes Association (ADA)11 and the US NationalInstitutes of Health (NIH)12: reduce the consumption of fast,convenience and processed foods; eat more fruits,vegetables whole grains and omega-3 rich fish and be morephysically active.

Whole Food Nutrition for Lifelong Healthand Vitality... in convenient, on-the-go packetsWhole Food Nutrition for Lifelong Healthand Vitality... in convenient, on-the-go packets

Tre-en-en® Grain Concentrates Carotenoid Complex Omega-III Salmon Oil Plus

DIETARY SOLUTIONS

Whole Grains

Fruits & Vegetables

Fish

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References1 The Journal of the American Medical Association; August 2007, Vol. 298,

Number 7, pp 754 to 7642 American Journal of Clinical Nutrition; July 2007, Vol. 86, Number 1, pp 221-2293 Burns, J. Low Dietary Nutrient Intakes and Respiratory Health in Adolescents.

Chest. July 2007; 132:238-2454 Journal of Food Chemistry; November 20055 Annual meeting of the Soil Science Society of America, November 2000.

http://www.soils.wisc.edu/~barak6 Popkin, B.; global nutrition dynamics: the world is shifting rapidly toward a

diet linked with noncommunicable diseases. American Journal of ClinicalNutrition; Vol. 84, pp 289-298, 2006

7 Preventing chronic disease: a vital investment. World HealthOrganization,2005: www.who.int/chp/chronic_disease_report/en/index.html

8 www.americanheart.org/presenter.jhtml?identifier=8519 www.cdc.gov/nccdphp/10 www.cancer.gov/cancertopics/prevention-genetics-causes/prevention11 http://www.diabetes.org/nutrition-and-recipes/nutrition/overview.jsp12 http://ndep.nih.gov/13 Gorter, E.; Grendel, F. On bimolecular layers of lipoids on the chromocytes of

the blood., Journal of Experimental Medicine 41: 439-443, 192514 Hodgkin, A.L.; Keynes, R.D., Active transport of cations in giant axons. -

Journal of Physiology, 128:26-60, 195515 Chapman, D. Lipid dynamics in cell membranes. Cell membranes:

Biochemistry, Cell Biology and Pathology, pp 13-22, 197516 Kubena, K.S.; Fat and mineral metabolism as affected by source of fat and

exercise in rats. Texas A&M University, 1987 (unpublished)17 Whole grain intake may reduce the risk of ischemic heart disease in death in

post-menopausal women: The Iowa Women’s Health Study, Am J Clin Nutr,1998 68:248-257

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19 Whole grain consumption and risk of ischemic stroke in women: A prospectivestudy. JAMA 2000; 284:1534-1540

20 Consumption of a functional oil rich in phytosterols and medium chaintriglycerides oil improves plasma lipid profile in men; Human Nutrition &Metabolism, May 2005: publ on-line

21 Phytosterols as anticancer dietary components: Evidence and Mechanism ofAction; Human Nutrition & Metabolism, May 2005: publ on-line

22 Minhajuddin, M., University of Rochester: Food and Chemical Toxicology;May 2005

23 Rice bran oil and cholesterol, Am J Clin Nutr; March 200524 Whole grain intake and cardiovascular disease: A meta-analysis; Mellen, P.b.,

et al; Nutrition, Metabnolism & Cardiovascular Diseases; published on-line10.1016

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among white men in New Jersey; 1986, American Journal of Epidemiology,123:1080-1093

27 Ziegler, R. G., A review of epidemiologic evidence that carotenoids reduce therisk of cancer. 1989. Journal of Nutrition. 119:116-122

28 Ziegler, R. G., Vegetables, Fruits, and carotenoids and the risk of cancer. 1991.Am. Jour. Clin. Nutr. 53:251S-259S

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30 Rimm, E. B., et al: Dietary intake and risk of coronary heart disease in men.1993, New England Journal of Medicine. 328:1450-1456

31 Knekt, P., et al; Serum antioxidant vitamins and risk of cataract. 1992. BritishMedical Journal. 305:1392-1394

32 Carotenoids in Human Health, 1993. Annals of the New York Academy ofSciences. 691:61-67

33 Carughi, A. & Hooper, FG. Plasma carotenoid concentrations beore and aftersupplementationwith a carotenoid mixture. 1993. Annals of the New YorkAcademy of Sciences. 691:244-245

34 Carughi, A., Hooper, FG.; Plasma carotenoids before and after supplementationwith a carotenoid mixture; American Journal of Clinical Nutrition 1994; Volume59, pages 896-9

35 Z Dixon, B Burri, J Erdman, et al ; Effects of a carotene-deficient diet onmeasures of oxidative susceptibility and superoxide dismutase activity in adultwomen;; Free Radical Biology & Medicine, Volume 17, Number 6, pages 537-44

36 Y Lin, B Burri, et al; Effects of low dietary carotene intake on oxidativesusceptibility in women; FASEB Journal, Volume 10, Number 3, page A478,April 1996

37 Z Dixon, B Burri, et al; Effect of low carotene diet on malondialdehyde(MDA) concentration; FASEB Journal, Volume 10, Number 3, page A240,April 1996

38 T Kramer, B Burri, et al; Carotenoid-flavonoid modulated immune response inwomen; FASEB Journal, Volume 9, Number 3, page A170, April 1995

39 T Kramer, B Burri, et al; Modulated mitogenic proliferative responsiveness oflymphocytes in whole-blood culture after a low-carotene diet and mixed-carotenoid supplementation in women; American Journal of Clinical Nutrition1997, Volume 65, pages 871-5

40 Carughi, A., Omaye, S., Furst, A.; Plasma carotenoid response tosupplementation of a mix of fruits and vegetables; Proceedings of ExperimentalBiology, March 31 – April 4, 2001

41 http://www.cdc.gov/nccdphp/dnpa/5ADay/42 http://www.cancer.gov/cancertopics/prevention-genetics-causes/prevention43 Stroke. 2004; 35:1584-158844 2008, Journal of Nutrition: February, 138:344-350.45 2006. Nutrition, Metabolism and Cardiovascular Disease.Published on-line:

doi: 10.1016/numecd.2006.02.00646 Urological Oncology (vol. 23, pp. 383-385)47 Ophthalmology (BMC Ophthalmology 2006, 6:23)48 The Journal of Gerontology: Medical Science; 2007; 3:308-31649 American Journal of Clinical Nutrition; 2005: vol. 82, no. 2:451-45550 Nettleton, J. A., 1995. Omega-3 Fatty Acids & Health, Chapter 3; Omega-3

Fatty Acids and Heart Disease; 77-13751 Rabinovich, I. M. 1936, Clinical and other observation on Canadian Eskimos

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district, Greenland. Acta Medica Scandanavia. 208:401-406.54 Carughi, A. Effect of Omega-3 Fatty Acid Supplementation on Omega-3 Index

and Red Blood Cell (RBC) Membrane Fatty Acid Composition. Annualmeeting of Experimental Biology, April 2008

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56 Effect of GNLD Salmon Oil Plus on Markers of Cardiovascular Health andInflammation. News You Can Use, Volume 21, 2008

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pp 1142-1147, April 200763 American Journal of Clinical Nutrition; Vol. 85; pp 1103-1111, April 200764 Progress in Neuro-Psychopharmacology and Biological Psychiatry Vol. 32,

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