Principles of Immunology Tumor Immunology 4/25/06.
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Transcript of Principles of Immunology Tumor Immunology 4/25/06.
Principles of Immunology
Tumor Immunology4/25/06
Word/Terms List AFP Benign Carcinoma CEA Leukemia Lymphoma Malignant Metastasis Neoplasm Oncogene Sarcoma Transformation TSTA
Tumor Immunology
Benign vs. malignant tumors
Types of neoplasms
Carcinomas Leukemias/lymphomas Sarcomas
Cell Transformation
Characteristics
Nutritional changes
Lack of contact inhibition
Immortality
Chemicals and Cancer
Mitogens
Mutagens
Carcinogens
Genes and Cancer
Oncogenes
Proto-oncogenes
Tumor-specific Transplantation Antigens
Origin of TSTAs
Point mutations Expressed by germ line cells Expressed by specific cell types Over expressed Post translation changes Viral oncogenes
Oncofetal Antigens
Alpha fetoprotein (AFP)
Carcinoembryonic antigen (CEA)
Tumors of the Immune System
Leukemias ALL AML CLL CML
Lymphomas
Tumors and Viruses
Hepatitis B
Human papilloma virus(HPV)
Epstein Barr Virus
Tumors and Evasion of the Immune System
Low immunogenicity
Modulation by antibodies
Tumor secreted suppressors
Immune Response to Tumors
Cells NK CTLs Macrophages
Cytokines Interferon TNF
Immunotherapy Against Tumors
ADCC
Toxin conjugation
Radionuclide conjugation