Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for...
-
Upload
charlie-graham -
Category
Documents
-
view
215 -
download
0
Transcript of Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for...
![Page 1: Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.](https://reader030.fdocuments.in/reader030/viewer/2022032702/56649c9c5503460f9495b85c/html5/thumbnails/1.jpg)
Principles of Immunology
Overview of Innate Immunity1/19/06
“Education is not preparation for life. Education is life itself.”
John Dewey
![Page 2: Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.](https://reader030.fdocuments.in/reader030/viewer/2022032702/56649c9c5503460f9495b85c/html5/thumbnails/2.jpg)
Review(T/F)
Jenner was the first to introduce variolation
Innate immune responses are specific T cells are either T-helper or T-
cytotoxic cells Immunological memory results in an
amanestic response All antigens are immunogens
![Page 3: Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.](https://reader030.fdocuments.in/reader030/viewer/2022032702/56649c9c5503460f9495b85c/html5/thumbnails/3.jpg)
Innate Immunity
Nonspecific host defenses that exist prior to exposure to an antigen. Involves the following components:
Anatomic Physiologic Phagocytic Inflammatory
![Page 4: Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.](https://reader030.fdocuments.in/reader030/viewer/2022032702/56649c9c5503460f9495b85c/html5/thumbnails/4.jpg)
Word List Antibody Antigen Complement Endocytosis Humoral Macrophage Monocyte Neutrophil
![Page 5: Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.](https://reader030.fdocuments.in/reader030/viewer/2022032702/56649c9c5503460f9495b85c/html5/thumbnails/5.jpg)
Barriers to Antigenic Insult
Anatomic Skin Mucous membranes
Physiologic Temperature pH Chemical mediators
![Page 6: Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.](https://reader030.fdocuments.in/reader030/viewer/2022032702/56649c9c5503460f9495b85c/html5/thumbnails/6.jpg)
Cellular and Inflammatory Components of Innate Immunity
Cellular Phagocytic cells
Inflammatory Vasodilation Capillary permeability
![Page 7: Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.](https://reader030.fdocuments.in/reader030/viewer/2022032702/56649c9c5503460f9495b85c/html5/thumbnails/7.jpg)
Anatomic Barriers
Skin Epidermis Dermal layer Sebaceous glands Normal flora
![Page 8: Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.](https://reader030.fdocuments.in/reader030/viewer/2022032702/56649c9c5503460f9495b85c/html5/thumbnails/8.jpg)
Anatomic Barriers
Mucous membranes Physical barrier Secretions Cilia Normal flora
![Page 9: Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.](https://reader030.fdocuments.in/reader030/viewer/2022032702/56649c9c5503460f9495b85c/html5/thumbnails/9.jpg)
Physiologic Barriers
Temperature Varies by species Febrile response
Endogenous pyrogens
pH Skin GI tract
![Page 10: Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.](https://reader030.fdocuments.in/reader030/viewer/2022032702/56649c9c5503460f9495b85c/html5/thumbnails/10.jpg)
Physiologic Mediators of Innate Immunity
Chemical mediators Enzymes Interferon Complement
Three pathways Classical MB Lectin Alternative
![Page 11: Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.](https://reader030.fdocuments.in/reader030/viewer/2022032702/56649c9c5503460f9495b85c/html5/thumbnails/11.jpg)
Physiologic Mediators of Innate Immunity(cont’d)
Chemical mediators Collectins Toll-like receptors Acute phase proteins
![Page 12: Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.](https://reader030.fdocuments.in/reader030/viewer/2022032702/56649c9c5503460f9495b85c/html5/thumbnails/12.jpg)
Cellular Component of Innate Immunity
Phagocytic cells Monocytes Neutrophils Macrophages
Non-Phagocytic cells Natural killer cells
![Page 13: Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.](https://reader030.fdocuments.in/reader030/viewer/2022032702/56649c9c5503460f9495b85c/html5/thumbnails/13.jpg)
![Page 14: Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.](https://reader030.fdocuments.in/reader030/viewer/2022032702/56649c9c5503460f9495b85c/html5/thumbnails/14.jpg)
Inflammatory Response
Hallmarks of inflammation Rubor Tumor Calor Dolor
Primary cell Activated macrophage
![Page 15: Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.](https://reader030.fdocuments.in/reader030/viewer/2022032702/56649c9c5503460f9495b85c/html5/thumbnails/15.jpg)
Inflammatory Response(cont’d)
Biological effects Vasodilation Capillary permeability Phagocyte migration
![Page 16: Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.](https://reader030.fdocuments.in/reader030/viewer/2022032702/56649c9c5503460f9495b85c/html5/thumbnails/16.jpg)
![Page 17: Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.](https://reader030.fdocuments.in/reader030/viewer/2022032702/56649c9c5503460f9495b85c/html5/thumbnails/17.jpg)
Inflammatory Response(cont’d)
Chemical mediators of inflammation Histamine Kinin system Fibrin system
![Page 18: Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey.](https://reader030.fdocuments.in/reader030/viewer/2022032702/56649c9c5503460f9495b85c/html5/thumbnails/18.jpg)