PrimePrime AGE Defense™ AGE Defense™ FormulaFormula

MarketMarket AmericaAmerica

Convention 2009Convention 2009Presented by: Jan DeBenedettoPresented by: Jan DeBenedetto

Disclaimer

This presentation has not been evaluated by the

Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any

disease.

What are AGEs?What are AGEs?OverviewOverview AAdvanced dvanced GGlycation lycation EEndproductsndproducts

– Chronic high levels of AGEs are proven to Chronic high levels of AGEs are proven to accelerate the aging process accelerate the aging process

– They are a diverse group of highly reactive They are a diverse group of highly reactive substances substances

– In excess can wreak havoc in the bodyIn excess can wreak havoc in the body– Many AGEs are sugar derived aldehydes Many AGEs are sugar derived aldehydes

(glyoxals)(glyoxals)– They can cause generalized cellular They can cause generalized cellular

dysfunctiondysfunction i.e. they can affect the entire body!i.e. they can affect the entire body!

– Also known as Also known as GlycotoxinsGlycotoxins

AGEs - AGEs - Naturally Naturally

AGEs are produced naturally in AGEs are produced naturally in normal metabolism and the body can normal metabolism and the body can handle low levels of AGEshandle low levels of AGEs

AGEs are consumed at a moderate AGEs are consumed at a moderate level as part of a reasonably good level as part of a reasonably good dietdiet

The problems occur due to the The problems occur due to the chronic overproduction and over chronic overproduction and over consumption of AGEs as well as consumption of AGEs as well as cigarette smokingcigarette smoking

NOTHING IN BIOLOGY MAKES SENSE NOTHING IN BIOLOGY MAKES SENSE EXCEPT IN THE LIGHT OF EVOLUTIONEXCEPT IN THE LIGHT OF EVOLUTION

Theodosius Dobzhansky -- Russian evolutionary biologist

Historical Perspective of Historical Perspective of AGEsAGEs

Our current genome Our current genome evolved on evolved on – A low sugar dietA low sugar diet– A low saturated fat A low saturated fat

dietdiet– A high fiber dietA high fiber diet– An alkaline dietAn alkaline diet– A nutrient dense diet A nutrient dense diet – A chemical / drug A chemical / drug

free dietfree diet Our current genome Our current genome

evolved in a evolved in a physically active physically active humanhuman

But what do we do?But what do we do?– Eat a high sugar dietEat a high sugar diet– Eat a high sat fat dietEat a high sat fat diet– Eat a low fiber dietEat a low fiber diet– Eat a chronic low acid Eat a chronic low acid

dietdiet– Eat lots of empty caloriesEat lots of empty calories– Eat processed and fake Eat processed and fake

foods, lots of Rx & OTCsfoods, lots of Rx & OTCs We are much less active We are much less active

than ourthan our ancestorsancestors

Historical Perspective - Historical Perspective - 22 Only within the last 200 years Only within the last 200 years (a (a

blip on the genetic radar screen)blip on the genetic radar screen) did we have simple sugars so did we have simple sugars so readily availablereadily available– Mostly during the last 50 yearsMostly during the last 50 years

We are dissonant with our genome We are dissonant with our genome and that ain’t a good thing.and that ain’t a good thing.– Don’t mess with Mother NatureDon’t mess with Mother Nature……

AGEs AGEs Can Affect the Following:Can Affect the Following:

Oxidative StressOxidative Stress Collagen cross-linkingCollagen cross-linking

– Wrinkles and stiffnessWrinkles and stiffness Mitochondrial functionMitochondrial function

– Cellular powerhousesCellular powerhouses Kidney functionKidney function Genetic transcription proteinsGenetic transcription proteins

AGEs and arteriesAGEs and arteries

Normal diet artery Low AGE diet artery

AGEs and VertebraeAGEs and Vertebrae

Glycated bone Glycated bone collagencollagen

Excess AGEs Excess AGEs Inside and OutInside and Out The body can make AGEsThe body can make AGEs

Excess carbsExcess carbs Excess sugarExcess sugar Chronic stressChronic stress

Food AGEsFood AGEs– Foods cooked at high temperatures and for a long timeFoods cooked at high temperatures and for a long time

Frying, grilling, roasting and broilingFrying, grilling, roasting and broiling Especially in presence of sugars Foods that are cooked until Especially in presence of sugars Foods that are cooked until

brown brown Browning reaction or Maillard reaction generates AGEsBrowning reaction or Maillard reaction generates AGEs

– Carbonated non-diet beveragesCarbonated non-diet beverages– Processed foodsProcessed foods

Cigarette smokingCigarette smoking– Add AGEs to the long list of cigarette toxinsAdd AGEs to the long list of cigarette toxins

Why haven’t we Why haven’t we hearing more about hearing more about AGEs?AGEs?

The research is relatively new dating The research is relatively new dating back to the late ’80’s.back to the late ’80’s.

Most scientific publications are from this Most scientific publications are from this millenniamillennia– Out of 2373 Medline scientific literature Out of 2373 Medline scientific literature

citations, 85% are from after the year 2000!citations, 85% are from after the year 2000! RationaleRationale

– Industry lobby efforts that negatively Industry lobby efforts that negatively influenced research fundinginfluenced research funding

– No major Pharma companies with Rx to No major Pharma companies with Rx to address issue. address issue.

AGEs and AgingAGEs and Aging

The degree of Glycation of a cell is used as The degree of Glycation of a cell is used as recognition signal of senescent (old/aged) recognition signal of senescent (old/aged) targets for excretion or catabolism.targets for excretion or catabolism.

In other words in many cases otherwise In other words in many cases otherwise healthy cells are tagged and removed due to healthy cells are tagged and removed due to their being glycated and therefore will not their being glycated and therefore will not divide into new cells. divide into new cells.

Smoking and AGEsSmoking and AGEs

AGE AGE accumulation in accumulation in the cornea of the cornea of NonSmokers (NS) NonSmokers (NS) and Smokers (S)and Smokers (S)

AGEs in the bodyAGEs in the body

Glycation leads to a large and diverse Glycation leads to a large and diverse range of chemical speciesrange of chemical species

This makes them deleterious to a This makes them deleterious to a variety of tissuesvariety of tissues

This also makes it difficult to This also makes it difficult to commercially measure AGEs at this commercially measure AGEs at this point in timepoint in time– Measuring HbA1c is a good indicatorMeasuring HbA1c is a good indicator

Glycated Hemoglobin Glycated Hemoglobin

Glucose, AGEs & TimeGlucose, AGEs & Time

Dietary AGEsDietary AGEs

StudyStudy– on 4 week “Low AGE” diet => decreased LDL by on 4 week “Low AGE” diet => decreased LDL by

28%!28%!– on “High AGE” diet LDL increased by 50%!on “High AGE” diet LDL increased by 50%!

StudyStudy– 6 week High AGE diet 6 week High AGE diet

Increased LDL 33%Increased LDL 33% CRP increased 35%CRP increased 35%

– 6 week Low AGE diet6 week Low AGE diet Decreased LDL 32%Decreased LDL 32% CRP decreased 20%CRP decreased 20%

Dietary AGEs - 2Dietary AGEs - 2

Rat study with two groups, Rat study with two groups, – The “High AGE” diet rats had higher The “High AGE” diet rats had higher

insulin resistance, oxidative stress, insulin resistance, oxidative stress, inflammation renal and CV damage and inflammation renal and CV damage and lower glutathione.lower glutathione.

– The group with 50% reduced AGE diet The group with 50% reduced AGE diet lived significantly longer than the other lived significantly longer than the other group (~21%) and with lower group (~21%) and with lower inflammatory markers.inflammatory markers.

Prime™ AGE DefensePrime™ AGE DefenseTo the Rescue!To the Rescue! 

 Supplement Facts      

  Serving Size: 3 tabletsServings Per Container: 30

     

    Amount Per Serving % Daily Value  

  Thiamine (as Benfotiamine) 55 mg 4583%  

  Taurine 1,000 mg *  

  N-acetylcysteine 200 mg *  

  American ginseng root  extract (5% ginsenosides) 500 mg    

  Cinnamon bark extract 250 mg *  

  * Daily value not established.      

     

BenfotiamineBenfotiamine

A lipid soluble form of ThiamineA lipid soluble form of Thiamine– This allows for greater absorption than This allows for greater absorption than

commercial thiamine and thus higher commercial thiamine and thus higher blood levelblood level

– Supports the body’s normal ability to Supports the body’s normal ability to remove AGEsremove AGEs

– Protects endothelium (an active, vital thin Protects endothelium (an active, vital thin layer of cells that line blood vessels) layer of cells that line blood vessels) against AGEsagainst AGEs

American GinsengAmerican GinsengPanax quinquefoliusPanax quinquefolius

Promotes normal serum levels of glucosePromotes normal serum levels of glucose Powerful AdaptogenPowerful Adaptogen Active components are ginsenosides Rb1, Rd Active components are ginsenosides Rb1, Rd

and Re and Re Promotes normal levels of carboxymethyl-Promotes normal levels of carboxymethyl-

lysine (CML) and its receptors for (AGE) in lysine (CML) and its receptors for (AGE) in kidneykidney

Cinnamon Bark Cinnamon Bark ExtractExtract

Promotes healthy metabolism of Promotes healthy metabolism of glucoseglucose

Helps maintain normal insulin Helps maintain normal insulin sensitivitysensitivity

Strong antioxidantStrong antioxidant

N-AcetylcysteineN-Acetylcysteine

Sulfur rich antioxidant that is a powerful Sulfur rich antioxidant that is a powerful antioxidantantioxidant

Promotes healthy glutathione levelsPromotes healthy glutathione levels– Glutathione is one of the body’s natural Glutathione is one of the body’s natural

AGE scavengersAGE scavengers Helps maintain normal levels of CML (an Helps maintain normal levels of CML (an

AGE)AGE) Supports a healthy liver and kidneysSupports a healthy liver and kidneys

TaurineTaurine

A sulfhydryl derivative of an amino acidA sulfhydryl derivative of an amino acid Found in abundance in slow twitch Found in abundance in slow twitch

(endurance) muscle fibers (endurance) muscle fibers Taurine levels are typically lower with aging Taurine levels are typically lower with aging

and vegan dietsand vegan diets Has numerous other healthful functionsHas numerous other healthful functions

Who can benefit most Who can benefit most from Prime™ AGE from Prime™ AGE Defense?Defense? SmokersSmokers Individuals who want to age wellIndividuals who want to age well If you indulge your sweet toothIf you indulge your sweet tooth

– Eating and drinkingEating and drinking Eat lots of Grilled, Broiled, Fried Eat lots of Grilled, Broiled, Fried

foodsfoods Eat a lot of processed foodsEat a lot of processed foods If you have Metabolic Syndrome to If you have Metabolic Syndrome to

any degree any degree

Complimentary Complimentary Market America Market America AGE Support ProductsAGE Support Products

Arginine (Ultra Prime™)Arginine (Ultra Prime™) Isotonix OPC-3®Isotonix OPC-3® NutriClean® Aloe/Ultimate Aloe™NutriClean® Aloe/Ultimate Aloe™ Curcumin ExtremeCurcumin Extreme Heart Health™ Essential Omega Heart Health™ Essential Omega

IIIIII Isotonix® Vitamin D with K2Isotonix® Vitamin D with K2

AGE controlAGE controlSummarySummary Consume a Low AGE dietConsume a Low AGE diet Help maintain healthy blood sugar Help maintain healthy blood sugar

levels levels Control StressControl Stress Exercise regularlyExercise regularly NO SMOKINGNO SMOKING Take Prime™ AGE Defense Formula Take Prime™ AGE Defense Formula

regularly!regularly!

Ultra PrimeUltra Prime™™ Secretagogue & Secretagogue & Beyond!Beyond!

Ultra Prime™Ultra Prime™ Supports healthy levels of human Supports healthy levels of human

growth hormone (HGH)growth hormone (HGH) Functions as a secretagogue to naturally Functions as a secretagogue to naturally

increase the production and secretion of increase the production and secretion of HGH by the pituitary glandHGH by the pituitary gland

Recreates a youthful, natural pattern of Recreates a youthful, natural pattern of HGH production and release into the HGH production and release into the body. body.

It is not HGHIt is not HGH Safe and natural Safe and natural

Ultra Prime™Ultra Prime™

Powerful combination of amino acids Powerful combination of amino acids (the natural building blocks of (the natural building blocks of proteins) that have been scientifically proteins) that have been scientifically shown to effectively raise HGH levels. shown to effectively raise HGH levels.

Taken with proper timing, exercise Taken with proper timing, exercise and a healthy diet you can turn back and a healthy diet you can turn back the clock and increase your the clock and increase your HealthSpan!HealthSpan!

Common Growth Hormone Common Growth Hormone InhibitorsInhibitors

Stress hormones (Cortisol & Stress hormones (Cortisol & Epinephrine)Epinephrine)– RelaxRelax

InsulinInsulin– Don’t eat for 2 or more hours prior to Don’t eat for 2 or more hours prior to

bedtimebedtime Time of dayTime of day

– Sleep well (hGH levels rise during sleep)Sleep well (hGH levels rise during sleep)

Ultra PrimeUltra Prime™™ -- --Key IngredientsKey Ingredients All of the major ingredients in the All of the major ingredients in the

Prime secretagogues have published Prime secretagogues have published literature supporting their potential literature supporting their potential as nuitritional HGH secretagogues.as nuitritional HGH secretagogues.

BONUS!!! BONUS!!! – In addition, all of the major ingredients In addition, all of the major ingredients

in these formulations have numerous in these formulations have numerous other anti-aging related health benefits.other anti-aging related health benefits.

L-Arginine L-Arginine

Shown to be the amino acid that Shown to be the amino acid that enhances Nitric Oxide (NO) production enhances Nitric Oxide (NO) production (Nobel Prize work in 1998) (Nobel Prize work in 1998) (not Nitrous (not Nitrous oxide – laughing gas)oxide – laughing gas) – Helps maintain healthy blood pressureHelps maintain healthy blood pressure– Help maintain erectile functionHelp maintain erectile function– Help maintain healthy blood flowHelp maintain healthy blood flow– Enhance MoodEnhance Mood

Ultra Prime™ – Usage Ultra Prime™ – Usage

Use for hGH potentiation requires Use for hGH potentiation requires taking prior to bedtime on an taking prior to bedtime on an empty stomachempty stomach

Post of a strenuous workout to Post of a strenuous workout to enhance recoveryenhance recovery

Other benefits can be realized Other benefits can be realized taking it between mealstaking it between meals

Ultra Prime™Ultra Prime™

Top of the line hGH secretagoguesTop of the line hGH secretagogues Extraordinary adjunct to support Extraordinary adjunct to support

exerciseexercise Excellent for nutritional support for Excellent for nutritional support for

CV healthCV health Great for nutritional support of Great for nutritional support of

basic immune functionbasic immune function

Ultra PrimeUltra Prime™™ -- Summary -- Summary

Ultra Prime has so many more Ultra Prime has so many more health benefits to offer you above health benefits to offer you above and beyond hGH due to the and beyond hGH due to the unique, powerful and effective unique, powerful and effective formulationformulation

Try it for yourself and see Try it for yourself and see