PRICE CATALOGUE · 2019. 2. 6. · Growth curve of SPRAGUE DAWLEY RATS RjHan:SD * n=120 ♂ and 120...

Research Models

Laboratory Services

Reproductive Sciences

Customised breeding

[email protected] - T. +33 (0)2 43 02 11 91 - F. +33 (0)2 43 02 00 15

www.janvier-labs.com

PRICE CATALOGUE

2019

Prices valid from 01.01.2019

Nordic Countries

Research Models

> Rats...................p.6-8 > Aged animals...................p.9 > Mice...................p.10-18 > Other rodents...................p.18

Identify and select your research model

Reproductive Sciences

Confidently entrust us to safeguard and reproduce your strains

> Cryopreservation......................p.20 > Assisted reproduction............p.20 > Embryos and sperm kits..................p.21

Customised breedingFree up space in your animal facility by entrusting us with your colony breeding

> Customised breeding............................p.21 > Genotyping................................p.21 > Speed Congenics.................................p.21

Laboratory Services

Speed up your experiment protocols

> Biological products...............................p.22 > Surgery......................................p.23 > Experimental protocols...................p.23

TABLE OF CONTENTS

An ex-breeder is an animal originating from uncoupled animals at the end of the cycle.A reformed animal is an animal which is sold without age or weight criteria, subject to availability. Gerontobiology: for the ageing of inbred or outbred old breeders, please contact us.The delivered pregnant females are primiparous. Each ordered pregnant female will be invoiced. To guarantee the availability of pregnant females, we recommend you anticipate your programmed coupling requests.The weight of the animal mentioned on the order form corresponds to the weight on shipment day from JANVIER LABS.

> A genetic management concept ................................................................................................................................................................................ p.4 > A rigorous health policy ................................................................................................................................................................................................ p.4 > A constant concern for animal welfare .................................................................................................................................................................... p.4 > The largest and most advanced rodent breeding site ........................................................................................................................................ p.5 > Your satisfaction, our priority ....................................................................................................................................................................................... p.5

The partner you can rely on

> An in-house transport service...................................................................................................................................................................................... p.24 > International routes ........................................................................................................................................................................................................ p.24 > Stress management for animal transportation ..................................................................................................................................................... p.24 > Weekly deliveries ............................................................................................................................................................................................................. p.25 > Packaging adapted to animal’s health status ......................................................................................................................................................... p.25

Transport and packaging

General terms and conditions........................................................................................................................ p.26-27

Over the past 3 years, JANVIER LABS has invested heavily to design and build with its teams of experts, a tool at the forefront of innovation able to serve its customers at the best possible level.

We wanted this tool to be modern and efficient, based on high-tech health processes involving innumerable levels of security, because «health excellence» means «no compromise».

JANVIER LABS: It’s the story that began with a mouse and developed into a family-run company with strong values. That was in France in 1960 … more than half a century ago already. It’s from those same genes that our vision, ambition and strategy were born.

Our customers are at the centre of our work. JANVIER LABS is a company that listens to its customers. You are the ones who lead us on our quest for excellence: excellence in health standards, excellence in quality, excellence in customer satisfaction.

As a partner of your day-to-day business, JANVIER LABS is able to provide you with a fully reliable experimental environment with a very high genetic stability so that your research work can be facilitated, repeatable and reliable.

We have a deep respect for the work you do. This respect is illustrated in each gesture of our procedures. At JANVIER LABS, our ethical attitude begins where our story first began, in our breeding activity.

A company with cutting-edge innovation means a company that is agile and reactive. JANVIER LABS puts all its energy into bringing you constantly updated and exceptionally high quality services.

All of this is possible thanks to our committed employees, forming conscientious teams working with professionalism and precision to answer our customers’ needs in the understanding that excellence in health and safety is a team objective.

JANVIER LABS is in a perpetual state of development with the most advanced equipment, constantly improved processes and the level of its health and genetic standards, whilst attracting the best talents.

JANVIER LABS has fulfilled its commitments by investing today for tomorrow’s research. We have made no short-cuts on quality or security, with the aim to serve and satisfy you. Chairwoman General Director

THE PARTNER YOU CAN RELY ON

4

A genetic management conceptThe steps taken by JANVIER LABS are to ensure the purity and genetic stability of our research models and to ensure the security of supply to our customers. It can be defined as followed: genetic stability over time.

• The stability of the models: we ensure the homozygosity of our inbred models and thus guarantee the stability of their genetic characteristics over time. Outbred strains are managed to ensure the maintenance of allelic variation and less than 1 % inbreeding.

• Genetic stability: our breeding pairs are engaged in a 5-year production cycle, that is, 10 generations of crosses. Geneticians consider that a significant risk of genetic drift occurs after 10 generations. We anticipate this risk by replacing all the breeders of each strain in each animal facility restarting from cryopreserved embryos between the seventh and the tenth generation. We guarantee our production with a sufficient stock of embryos for the 50 years to come, thus, we assure you a genetic stability. Our breeding pairs have been fully sequenced and controlled for phenotypical, biochemical and hematological data as well.

• The stability of supply: each strain is simultaneously bred in several production units within our breeding buildings. All this, in order to guarantee you the best possible supply.

A rigorous health policy• The rigor: the health policy is our priority and does not tolerate any concession. Benefiting from the highest health status, our SPF and

SOPF animals are subject to numerous containment measures and are regularly monitored. For sentinel animals, even stricter conditions are applied and these are bred in isolators to eliminate any risk.

• Independence: the health controls and laboratory analyses are periodically carried out by reputable and independent organisations, who assure us of the strict respect of the recommendations of reference organisations such as FELASA.

• Transparency: health controls are carried out regularly (every 6 weeks) and our health certificates are published and can be consulted on our website.

Animal welfare is at the heart of our business. It affects us daily, as much as it does researchers, because calm animals both in breeding and experimentation ensure a production of the best quality and homogeneous results.

• The state of health: the health policy envisaged by JANVIER LABS is the most demanding, the SPF and SOPF status are the norm and our teams ensure it is maintained. Diseases and abnormalities are regularly monitored in our production units.

• Sufficient comfort: grouping standards are scrupulously respected. Our animals are bred in medium sized animal facilities to reduce noise, stress and other sources of conflict.

• An adapted diet: our animals are fed with a food specifically studied according to the species, the strain and their physiological needs.

• Safety: we do not mix species to minimise stress and avoid competition. We thus ensure a calm environment, conducive to the good development of our models.

• Socialisation policy: our animals are manipulated by hand. This ensures more docile animals, not afraid of the presence of man. Similarly, grouping favours social interactions between congeners. We let animals resort to their natural instincts such as nest creation and rodent activity with the toys we provide them.

A constant concern for animal welfare

SPF : Specific Pathogen Free according to FELASA recommendationsThe tested pathogens are: • Bacteria• Endoparasites• Ectoparasites• VirusA necropsy examination is systematically performed.

SOPF : Specific Opportunist Pathogen FreeThe tested pathogens are ones described in the SPF status, including the following opportunists:• Staphylococcus aureus• Proteus mirabilis, vulgaris• Klebsiella oxytoca, pneumonia• Pseudomonas aeruginosa

5

THE PARTNER YOU CAN RELY ON

Our new production units are equipped with the latest and most advanced innovations in terms of security, automated procedures, optimal work stations and health considerations, naturally. The production environment is strictly controlled within extremely stringent health procedures with many points of control, autoclaving and decontamination.

Your satisfaction: our priority

COMMITMENT

ETHICS

EXCELLENCE

REACTIVITY

RESPECT

PERFECTION

CUSTOMERSATISFACTION

CLIENT

• Sales assistance on hand and ready to help • Local sales representative for your specific needs • Team of veterinary surgeons and doctors to advise you • An ISO 9001 certified company for all our activities

Today, JANVIER LABS’ rodent production site is the largest and most advanced in Europe.

500 000

22 000 sqm

annual production capacity3 000 000 of rodents

of installations on a site of 8 hectares

rodents housed permanently

Our commitmentsAdaptability and reactivity

• Flexibility in order-taking • Tailor-made response to each of your requirements • Personalised accompaniment for your projects • A scientific follow-up specialised in rodents breeding

A single site for homogeneous and standardised production

Outbred rats

RESEARCH MODELS

Labo serviceResearch Transgenic service

WISTAR RjHan:WI

SPRAGUE DAWLEY® RjHan:SD (CD®)

LONG EVANS RjOrl:LE

6

Outbred rat

Technical sheet available on www.janvier-labs.com

Outbred rat

Outbred ratTechnical sheet available

on www.janvier-labs.com

* as indicative basis.For animals with SOPF status: please contact us.

SD®is a registered trademark of Envigo. All rights reserved.CD® is a registered trademark of Charles River. All rights reserved.

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Growth curve of WISTAR RjHan:Wl RATS *

n=120 ♂ and 120 ♀

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Growth curve of SPRAGUE DAWLEY RATS RjHan:SD *

n=120 ♂ and 120 ♀

Age in days

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MalesFemales

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Growth curve of LONG EVANS RjOrl:LE RATS *

n=120 ♂ and 120 ♀


Weight(in grams)

Price in Euros

MALE FEMALE

Up to 49 9,33 9,3350 to 74 10,51 10,2175 to 99 12,29 11,23100 to 124 12,79 11,87125 to 149 13,27 13,25150 to 174 15,18 15,48175 to 199 16,75 16,99200 to 224 17,59 18,16225 to 249 18,14 19,77250 to 274 19,78275 to 299 21,52300 to 324 23,17325 to 349 26,43

For each extra week 2,40Time-mated pregnant female, guaranteed at E15 on delivery date 93,79Not-guaranteed pregnant female 69,80Female with litter (10-12 pups*) 99,79Old breeders 9,33

Weight(in grams)

Price in Euros

MALE FEMALE

Up to 59 9,13 9,4060 to 74 10,10 9,7875 to 99 11,64 10,89100 to 124 12,62 11,46125 to 149 13,89 12,74150 to 174 15,18 14,94175 to 199 15,99 16,21200 to 224 17,48 16,89225 to 249 19,72 17,60250 to 274 20,83275 to 299 22,28300 to 324 25,51325 to 349 26,96

For each extra week 2,39Time-mated pregnant female, guaranteed at E15 on delivery date 107,20Not-guaranteed pregnant female 76,83Female with litter (10-12 pups*) 112,07Old breeders 9,13 9,40

Weight(in grams)

Price in Euros

MALE FEMALE

Up to 49 14,31 14,31

50 to 74 17,49 15,67

75 to 99 19,95 16,00

100 to 124 20,45 20,45

125 to 149 22,37 22,73

150 to 174 24,08 25,02

175 to 199 24,41 26,82

200 to 224 28,62 29,47

225 to 249 30,51

250 to 274 33,19

275 to 299 34,08

300 to 324 38,39


RESEARCH MODELS


DARK AGOUTI DA/HanRj

LEWIS LEW/OrlRj

FISCHER F344/HanZtmRj

7


Inbred rat


Inbred rat


Inbred rat

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Growth curve of DARK AGOUTI DA/HanRj RATS *

n=48 ♂ and 48 ♀

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Growth curve of LEWIS LEW/OrlRj RATS *

n=48 ♂ and 48 ♀

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Growth curve of FISCHER F344/HanZtmRj RATS *

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Évolution pondérale des RATS FISCHER F344/HanZtmRj *

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Évolution pondérale des RATS FISCHER F344/HanZtmRj *

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Évolution pondérale des RATS LEWIS LEW/OrlRj *

n=48 ♂ et 48 ♀

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Growth curve of FISCHER F344/HanZtmRj RATS *

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Growth curve of BALB/cAnNRj-Foxn1nu/Foxn1nu Mice *

n=300 ♂ and 300 ♀Age in weeks




BLACK HOODED or PVGPVG/OrlRjInbred rat

Price on

request Price on

request Price on

request

BROWN NORWAYBN/OrlRjInbred rat

FAWN HOODEDRjIbm:FHOutbred rat

Age (in weeks)Price in Euros

MALE or FEMALE3 27,794 29,245 33,096 36,537 42,058 44,29

For each extra week 3,86


MALE or FEMALE3 21,494 25,025 27,856 32,367 36,618 41,109 44,53



MALE or FEMALE3 44,064 48,305 53,926 60,237 67,918 75,599 82,91


RESEARCH MODELS


WISTAR KYOTO WKY/KyoRj

SHR SHR/KyoRj

8


Mutant rat


Mutant rat

SPRAGUE DAWLEY®is a registered trademark of Envigo. All rights reserved.

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Growth curve of WISTAR KYOTO WKY/KyoRj RATS *

n=48 ♂ and 24 ♀

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Growth curve of SHR/KyoRj RATS *

n=48 ♂ and 24 ♀

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3528 42 49 56 63 70 77 84 91 98 105 112


SPRAGUE DAWLEY® Hairless Rj:SDH-Dsg4Mutant rat

Price on

request


LOU-nuLOU/MRj-Foxn1rnu

Mutant rat

Price on

request


Athymic rat ATHYM/Rj-Foxn1rnu/rnu

Mutant rat

Price on

request


FISCHER Nude F344/HanZtmRj-Foxn1rnu/rnu

Mutant rat

Price on

request

NEWNEW


Diabetic BBDRBBDR.cg-Leprdb/db.cp/LundRjMutant rat

Price on

request

NEW


MALE3 26,104 31,565 34,426 40,467 46,778 50,789 58,73

10 66,1911 73,3412 79,64

For each extra week 7,31Old breeders 26,10


MALE3 49,714 50,755 55,326 61,347 66,518 74,819 82,02

10 89,2411 96,2212 104,63


RESEARCH MODELS


9

Aged animals

Aged WISTAR RjHan:WI

Aged C57BL/6JRj



We propose to age the rat strains you require. The animals to be aged will be selected at the age of 3 months and will be maintained the desired time. An additional number of animals to be aged is recommended to compensate for natural deaths during aging.

In stock

Upon reservation

We propose to age the mouse strains you require. The animals to be aged will be selected at the age of 3 months and will be maintained the desired time. An additional number of animals to be aged is recommended to compensate for natural deaths during aging.

In stock

Upon reservation

All the strains* of our catalogue can be aged.The animals to be aged will be selected at the age of 3 months and will be maintained the desired time.

Ask for the strain you need

* after confirmation by our vet department


MALE3 26,104 31,565 34,426 40,467 46,778 50,789 58,73

10 66,1911 73,3412 79,64



MALE3 49,714 50,755 55,326 61,347 66,518 74,819 82,02

10 89,2411 96,2212 104,63


Age (months)

Price in Euros Age

(months)

Price in Euros Age (months)

Price in Euros

MALE MALE MALE

4 58,42 9 146,27 14 262,935 74,68 10 166,21 15 290,976 90,94 11 186,29 16

On request7 106,31 12 206,22 178 126,33 13 234,49 18

For rats older than 15 months, please contact us.

Age (months)

Price in Euros Age

(months)


Price in Euros

MALE MALE MALE

4 50,38 9 98,45 14 144,665 59,37 10 107,10 15 154,706 70,99 11 115,74 16 164,747 81,17 12 124,39 17 174,798 89,81 13 134,62 18 184,83

For mice older than 18 months, please contact us.

Age (months)

Price in Euros Age

(months)


Price in Euros

MALE or FEMALE MALE or FEMALE MALE or FEMALE

4 51,02 9 106,05 14 170,745 65,08 10 113,91 15 204,456 71,69 11 128,70 16

On request7 84,85 12 137,96 178 98,26 13 154,42 18

For rats older than 15 months, please contact us.

Age (months)

Price in Euros Age

(months)


Price in Euros

MALE or FEMALE MALE or FEMALE MALE or FEMALE

4 44,00 9 66,51 14 87,525 50,50 10 68,39 15 101,286 54,11 11 74,50 16 115,207 60,36 12 77,53 17 121,388 65,09 13 82,59 18 127,47

For mice older than 18 months, please contact us.

RESEARCH MODELS


C57BL/6JRj

C57BL/6NRj

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Inbred mouse


Inbred mouse

Age in days

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MalesFemales

Growth curve of C57BL/6JRj Mice *

n=160 ♂ and 160 ♀

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Growth curve of C57BL6/NRj Mice *

n=160 ♂ and 160 ♀


MALE or FEMALE3 14,234 15,135 16,506 16,867 17,118 17,559 17,81

10 19,8711 22,14



MALE or FEMALE3 12,834 13,955 15,346 16,157 16,748 17,26


BALB/cByJRj

BALB/cAnNRj

BALB/cJRj

RESEARCH MODELS


11

Inbred mouse

Inbred mouse

Inbred mouse





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Growth curve of BALB/cByJRj Mice *

n=160 ♂ and 160 ♀

n=160 ♂ and 160 ♀

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Growth curve of BALB/cAnNRj Mice *

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Growth curve of BALB/cJRj Mice *

n=160 ♂ and 160 ♀


MALE or FEMALE3 14,254 14,985 16,196 17,997 19,618 21,24



MALE or FEMALE3 13,204 13,875 14,946 15,737 16,398 16,89



MALE or FEMALE3 13,144 14,205 15,296 16,507 17,698 18,43

For each extra week 2,54Time-mated pregnant female, guaranteed at E16 on delivery date 89,66Not-guaranteed pregnant female 70,54Female with litter (5-6 pups*) 97,34

Old breeders 13,14

RESEARCH MODELS


DBA/1 DBA/1JRj

DBA/2 DBA/2JRj

C3H C3H/HeNRj

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Inbred mouse


Inbred mouse


Inbred mouse

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Growth curve of DBA1/JRj Mice *

n=160♂ and 160 ♀

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Growth curve of DBA/2JRj Mice *

n=160♂ and 160 ♀

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Growth curve of C3H/HeNRj Mice *

n=160 ♂ and 160 ♀


MALE or FEMALE3 22,124 25,275 28,326 30,387 34,478 38,06

For each extra week 3,50Pregnant female 97,94Female with litter (4-5 pups*) 148,85Old breeders 18,81


MALE or FEMALE3 17,644 18,255 19,536 20,937 22,148 23,61

For each extra week 2,51Pregnant female 86,12Female with litter (4-5 pups*) 114,98Old breeders 15,58


MALE or FEMALE3 16,224 17,215 18,346 19,917 21,898 23,72


RESEARCH MODELS


SJL SJL/JRj

CBA CBA/JRj

FVB FVB/NRj

13


Inbred mouse

Inbred mouse

Inbred mouse




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Growth curve of SJL/JRj Mice *

n=160 ♂ and 160 ♀

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Growth curve of CBA/JRj Mice *

n=160 ♂ and 160 ♀

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Growth curve of FVB/NRj Mice *

n=160♂ and 160 ♀


MALE or FEMALE3 22,664 23,715 26,366 29,177 31,788 34,54



MALE or FEMALE3 15,934 16,585 18,036 20,707 22,108 24,81



MALE or FEMALE3 13,364 14,245 16,636 17,407 20,318 21,09


RESEARCH MODELS


129/Sv 129S2/SvPasOrlRj

B6 Agouti B6/Rj-A/A

B6 Albinos B6/Rj-Tyrc/c

Athymic Nude Rj:ATHYM-Foxn1nu/nu

14

Growth curve of 129S2/SvPasOrlRj Mice*

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Inbred mouseTechnical sheet available


Coisogenic mouseTechnical sheet available


Growth curve of B6(C)RjTyrc/c Mice *

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n=300 ♂ and 300 ♀

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n=300 ♂ and 300 ♀

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n=300 ♂ and 300 ♀

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n=300 ♂ and 300 ♀

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n=300 ♂ and 300 ♀

Growth curve of B6(C)/Rj-A/A (B6 AGOUTI) Mice *

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Mutant mouseTechnical sheet available


NEW

Growth curve of B6/Rj-A/A* mice

Growth curve of B6/Rj-Tyrc/c* mice


MALE or FEMALE3 36,494 38,635 41,336 44,097 47,148 49,65



MALE or FEMALE3 22,724 23,835 24,846 25,927 28,048 30,15



MALE or FEMALE3 23,614 24,675 25,736 26,847 29,038 31,23



MALE or FEMALE4 37,575 41,916 44,817 47,708 50,58


RESEARCH MODELS


BALB/c-nu BALB/cAnNRj-Foxn1nu/nu

NMRI-nu Rj:NMRI-Foxn1nu/nu

CB17-SCID CB17/Icr-Prkdcscid/Rj

NOD-SCID NOD.CB17-Prkdcscid/Rj

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Mutant mouse


Mutant mouse

Mutant mouse

Mutant mouse




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30

35

28 35 42 49 56 63 70 77 84

Age in days

Wei

ght i

n gr

ams

MalesFemales


n=300 ♂ and 300 ♀

Age in days

Wei

ght i

n gr

ams

MalesFemales

21

0

5

10

15

20

25

30

35

40

45

28 35 42 49 56 63 70 77 84

Growth curve of Rj:NMRI-Foxn1nu/Foxn1nu Mice *

n=300 ♂ and 300 ♀

21

0

5

10

15

20

25

30

35

28 35 42 49 56 63 70 77 84

Age in days

Wei

ght i

n gr

ams

MalesFemales

Growth curve of CB-17/Icr-Prkdcscid/Rj Mice *

n=180 ♂ and 180 ♀

Growth curve of NOD.CB17/AlhnRj-Prkdcscid Mice*

21

0

5

10

15

20

25

30

28 35 42 49 56 63 70 77 84


Âge en jours

Poid

s en

gra

mm

es

21

0

5

10

15

20

25

30

35

28 35 42 49 56 63 70 77 84

Age in days

Wei

ght i

n gr

ams

MalesFemales


n=300 ♂ and 300 ♀

Évolution pondérale des SOURIS NOD.CB17/AlhnRj-Prkdcscid *

0

0

5

10

15

20

25

30

3 4 5 6 7 8 9 10 11 12


Âge en semaines

Poid

s en

gra

mm

es

Évolution pondérale des SOURIS NOD.CB17/AlhnRj-Prkdcscid *

0

0

5

10

15

20

25

30

3 4 5 6 7 8 9 10 11 12


Âge en semaines

Poid

s en

gra

mm

es

21

0

50

100

150

200

250

300

350

400

28 35 42 49 56 63 70 77 84

Poid

s en

gra

mm

es


Âge en jours

Évolution pondérale des RATS LEWIS LEW/OrlRj *

n=48 ♂ et 48 ♀

21

0

5

10

15

20

25

30

35

28 35 42 49 56 63 70 77 84

Age in days

Wei

ght i

n gr

ams

MalesFemales


n=300 ♂ and 300 ♀Age in weeks

Growth curve of BALB/cAnNRj-Foxn1nu/nu mice*

Growth curve of Rj:NMRI-Foxn1nu/nu mice*

Growth curve of NOD.CB17-Prkdcscid/Rj mice*

Growth curve of CB17/Icr-Prkdcscid/Rj mice*


MALE or FEMALE4 93,355 96,656 101,477 103,29

For each extra week (females) 4,81


MALE or FEMALE4 54,155 61,126 65,887 69,70

For each extra week (females) 4,18


MALE or FEMALE4 57,715 61,346 65,387 66,528 67,63



MALE or FEMALE4 98,135 100,376 102,457 110,758 111,64



MALE or FEMALE4 37,575 41,916 44,817 47,708 50,58


RESEARCH MODELS


DIABETIC BKS-Leprdb/db/JOrlRj

OBESE B6.V-Lepob/ob/JRj

16


Mutant mouse

OBESE Control B6.V-Lepob/+/JRj Control Mutant mouse


Mutant mouse



DIABETIC Control BKS-Leprdb/+/JOrlRj Control Mutant mouse

35

05

101520253035404550556065

42 49 56 63 70 77 84

Age in days

Wei

ght i

n gr

ams

MalesFemales

Growth curve of B6.V-Lepob/JRj Mice *

n=80

MalesFemales

35

05

1015

202530

354045505560

42 49 56 63 70 77 84

Age in days

Wei

ght i

n gr

ams

Growth curve of BKS(D)-Leprdb / JOrlRj Mice *

n=300 ♂ and 300 ♀

• Guaranteed delivery and availability• Homogeneity of the batches produced• More competitive prices

You can plan your needs:

Growth curve of B6.V-Lepob/ob/JRj mice*

Growth curve of BKS-Leprdb/db/JOrlRj mice*

• Guaranteed delivery and availability• Homogeneity of the batches produced• More competitive prices

You can plan your needs:


MALE or FEMALE5 151,586 155,927 159,958 164,80



MALE5 81,936 85,397 89,068 92,70



MALE or FEMALE5 117,526 121,697 128,968 133,55



MALE5 65,786 69,597 73,478 77,50


RESEARCH MODELS


B6D2F1 B6D2F1/JRj (E C57BL/6JRj x G DBA/2/JRj)

B6CBAF1 B6CBAF1/JRj (E C57BL/6JRj x G CBA/JRj)

B6SJLF1 B6SJLF1/JRj (E C57BL/6JRj x G SJL/JRj)

17


CSJLF1 CSJLF1/JRj(E BALB/cJRj x G SJL/JRj)

Hybrid mouse



Price

on request



C3D2F1 C3D2F1/JRj(E C3H/HeNRj x G DBA/2JRj)

Hybrid mouse

Price

on request


Growth curve of B6D2F1 Mice *

21

0

5

10

15

20

25

30

35

28 35 42 49 56 63 70 77 84

Age in days

Wei

ght i

n gr

ams

MalesFemales

n=160 ♂ and 160 ♀

Growth curve of B6CBAF1 Mice *

21

0

5

10

15

20

25

30

35

28 35 42 49 56 63 70 77 84

Age in days

Wei

ght i

n gr

ams

MalesFemales

n=160 ♂ and 160 ♀

Growth curve of B6 SJLF1 Mice *

21

0

5

10

15

20

25

30

35

28 35 42 49 56 63 70 77 84

Age in days

Wei

ght i

n gr

ams

MalesFemales

n=160 ♂ and 160 ♀


BIOZZI AsthmaticBP/2IcRj-BIOZZI

Mutant mouse

Price on

request


MALE or FEMALE5 151,586 155,927 159,958 164,80



MALE or FEMALE5 117,526 121,697 128,968 133,55



MALE or FEMALE3 13,344 14,145 15,526 16,407 17,178 17,94



MALE or FEMALE3 17,534 17,725 18,766 20,717 23,618 26,76


Hybrid mouse

Hybrid mouse


MALE or FEMALE3 22,834 24,055 25,636 26,467 27,718 29,25


Hybrid mouse

RESEARCH MODELS


SWISS RjOrl:SWISS (CD-1®)

18

21 28 35 42 49 56 63 70 77 84

Age in days

Wei

ght i

n gr

ams

MalesFemales

0

5

10

15

20

25

30

35

40

45

50

Growth curve of RjOrl:SWISS Mice *

n = 240


Outbred mouse

3

0102030405060708090

100110120130140150

4 5 6 7 8 9 10 11 12

Age in days

Wei

ght i

n gr

ams

MalesFemales

n=80 ♂ and 80 ♀

Growth curve of RjHan:AURA HAMSTERS *

Age in weeks


GOLDHAMSTER RjHan:AURA Outbred hamster


NMRI RjHan:NMRI

Outbred mousePrice

on request


GERBIL RjTub:MON

Outbred gerbil


Price

on request

CD-1® is a registered trademark of Charles River. All rights reserved.Time-mated pregnant female, guaranteed at E15 on delivery date 48,69

Not-guaranteed pregnant female 32,23Female with litter (10-12 pups*) 56,56Old breeders 4,33

Weight(in grams)

Price in Euros

MALE or FEMALE

10-12 5,03

12-14 5,26

14-16 5,50

16-18 5,74

18-20 5,98

20-22 6,27

22-24 6,57

24-26 6,86

26-28 7,19

28-30 7,59

30-32 7,99

32-34 8,39

34 et + On request

Weight(in grams)

Price in Euros

MALE or FEMALE40 - 49 34,5850 - 59 37,6960 - 79 44,2180 - 99 50,87

100 - 119 57,19For each extra week 7,46Pregnant female 137,60Female with litter 163,70Old breeders 34,58

REPRODUCTIVE SCIENCES

19

1

The Kit is available in

3 strains

6 strains

9 strains

Enables you to dramatically reduce costs associated with mouse colony maintenance, particularly of low use strains

Protects your valuable mouse strains against disease, breeding cessation and disaster

Media

3 ml vials, a vial is provided per strain

in each Kit, an additional vial is included for training purposes

T h e K i t co n s i st s o f 2 p a r t s :

1 From

1 Price valid for a 9-strain Kit

* JANVIER LABS is the exclusive commercial provider of The Jackson Laboratory’s JAX™ Sperm Cryo Kit in the following countries: Austria, Belgium, the Czech Republic, France, Germany, Hungary, Italy, Netherlands, Poland, Slovakia, Spain, Switzerland, Denmark, Finland, Norway, Sweden. JAX™ is a trademark of The Jackson Laboratory registered in the United States. All rights reserved.

25 straws are provided per strain in each Kit

20 for storage and 5 extra

4 cassettes for permanent storage and transport which contain 5 straws each

Straws and cassettes with unique identification numbers

Protects your research by:

limiting genetic drift

preventing the spontaneous loss of phenotype

enabling easy recovery of SOPF mice: no quarantine required upon arrival

facilitating strain transfer to collaborators

C r yo p re s e r va t i o n o f s p e r m :

230 €

Secure your researchwhilst saving resources through sperm cryopreservation of your mice with the JAX™ Sperm Cryo Kit*


20

* subject to the quality of the provided material in case of cryopreservation externallyJANVIER LABS is the exclusive commercial provider of The Jackson Laboratory’s JAX™ Sperm Cryo Kit in the following countries: Austria, Belgium, the Czech Republic, France, Germany, Hungary, Italy, Netherlands, Poland, Slovakia, Spain, Switzerland, Denmark, Finland, Norway, Sweden. JAX™ is a trademark of The Jackson Laboratory registered in the United States. All rights reserved. 1 Biopsies for genotyping if necessary2 This service can be performed by The Jackson Laboratory3 The Jackson Laboratory can recover your cryopreserved strains using JAX™ Mice host strains. Please contact JANVIER LABS for more details.

Description Objectives and details of the services

Sperm cryopreservation using the JAX™ Sperm Cryo Kit Technical sheet available on www.janvier-labs.com

Sperm cryopreservation 20 straws (each contains 4 aliquots of 10 µl of sperm - ready for use)

Embryo cryopreservation Technical sheet available on www.janvier-labs.com

Your strain x JANVIER LABS’ strain or your strain G and E 250 frozen embryos or 150 to 200 frozen embryos of the strain

Contrôle Qualité à partir de sperme ou d’embryons cryoconservés Technical sheet available on www.janvier-labs.com

Cryopreserved spermin vitro2 quality control 2-cell stage development rate after defrosting +

in vitro fertilisation

in vivo1,2 quality control Birth rate after implantation of embryos from QC1 into pseudogregnant females

Cryopreserved embryosin vitro quality control Viable embryo rate after defrosting and culture during 24 hours

(from 2-cell stage to morula stage)

in vivo1 quality control Birth rate after defrosting and reimplantation into pseudopregnant females

Cryo-storage of straws Technical sheet available on www.janvier-labs.com

Cryo-storage of frozen sperm straws2 Per year or long-time cryo-storage for 1 strain (up to 20 frozen sperm straws)

Cryo-storage of frozen embryos Per year or long-time cryo-storage for 1 strain (up to 250 frozen embryos)

Rederivation by embryo transfer Technical sheet available on www.janvier-labs.com

Rapid rederivation Your strain x JANVIER LABS’ strain or your strain G and E Restitution of at least 2 pregnant E

Complete rederivation Your strain x JANVIER LABS’ strain or your strain G and E Restitution of at least 3 to 6 SOPF males and 3 to 6 SOPF females

Recovery of a strain3 from cryopreserved sperm Technical sheet available on www.janvier-labs.com

From cryopreserved sperm using the JAX™ Sperm Cryo Kit or other method Restitution of at least 3 to 6 SOPF males and 3 to 6 SOPF females*

Recovery of a strain from cryopreserved embryos Technical sheet available on www.janvier-labs.com

From embryos cryopreserved by JANVIER LABS or by others Restitution of at least 3 to 6 SOPF males and 3 to 6 SOPF females*

Quick colony expansion by in vitro fertilisation Technical sheet available on www.janvier-labs.com

in vitro fertilisation from fresh or cryopreserved sperm (quantity on request from 40 animals) Restitution of the produced SOPF colony

Strain rescue Technical sheet available on www.janvier-labs.com

Strain rescue using the male Mating test and in vitro fertilisation Restitution of the produced SOPF animals

Strain rescue using the female Mating test and ovarian transplant Restitution of the produced SOPF animals

For any service of assisted reproduction, optional: identification and biopsy of pups born

Cryopreservation

Assisted reproduction


by The Jackson laboratory

21

Description Objectives and details of the services

Embryos kits

QUICKBLASTO® (blastocysts for ES cell injection) Technical sheet available on www.janvier-labs.com

Small 10 straws containing 25 frozen embryos each

Large 40 straws containing 25 frozen embryos each

Kit zygotes

Small 10 straws containing 25 frozen zygotes each

Large 40 straws containing 25 frozen zygotes each

Kit 2 cellules

Small 10 straws containing 25 frozen 2-cell stage embryos each

Large 40 straws containing 25 frozen 2-cell stage embryos each

Kit of sperm cryopreservation

JAX™ Sperm Cryo Kit Technical sheet available on www.janvier-labs.com

for 3 strains, for 6 strains and for 9 strains

Description

Customised breeding - Mouse / Rat - SPF4 or SOPF4,5

• Mating, weaning, stop mating, euthanasia• SOPF or SPF health monitoring controls• Follow-up and scientific support of the project by a dedicated project manager• Sending of a monthly follow-up report• Dedicated customised breeding software (AniBio) (24/7) :

• Module ANIMALS• Module BREEDINGS• Module FINANCIAL MANAGEMENT• Module SERVICES

Genotyping - Mouse / Rat

• Setup of PCR protocol• Genotyping by real-time PCR for one or several genes per biopsy• Fast and reliable results (24-48 hrs)

Speed Congenics - Mouse / Rat

• 50% time saving compared to classical backcross• At every generation, a panel of 1440 SNPs (mouse) or 96 SNPs (rat) is analysed on 20 samples• In a maximum of 5 generations, the animals are composed of more than 99.9% of the recipient

genome

Options : • Identification and biopsies• Programmed mating• Glycemia measurement• Weighing

4 Free from all pathogens registered in the FELASA list5 Free from opportunists defined by JANVIER LABS

QUICKBLASTO® is a registered trademark of JANVIER LABS. All rights reserved.

JAXTM is a trademark of The Jackson Laboratory registered in the United States. All rights reserved. (1) Europe includes Austria, Belgium, the Czech Republic, France, Germany, Hungary, Italy, Netherlands, Poland, Slovakia, Spain, Switzerland, Denmark, Finland, Norway, Sweden.

Cryopreservation

Assisted reproduction

CUSTOMISED BREEDING

Kits to facilitate your research

Kit of embryos to have embryos directly at different pre-implantation stages with JANVIER LABS genetic background

Kit of sperm cryopreservationExclusively marketed in Europe1 by JANVIER LABS


LABORATORY SERVICES

Biological products

22

The standard anti-coagulants are lithium heparin and EDTA K3. Bottled in 10 ml vials.For any other requests (anti-coagulants, packaging, strain, mutant models, age and sex determined), do not hesitate to contact us.

Products Species and characteristics of the models

Price in Euros (per ml)

1 to 100 ml 101 to 250 ml 251 to 500 ml

Blood products Technical sheet available on www.janvier-labs.com

Whole blood

Outbred rat

On request

Inbred ratOutbred mouseInbred mouseOther rodents

Plasma

Outbred ratInbred ratOutbred mouseInbred mouseOther rodents

Serum

Outbred ratInbred ratOutbred mouseInbred mouseOther rodents

Serum for embryo culture Outbred rat

Products Species and characteristics of the models Price in Euros

Organ sampling Technical sheet available on www.janvier-labs.com

Nervous system Brain with or without the cerebellum, spinal cord

All species On request

Endocrine system Adrenal glands, thyroid

Immune system Thymus, spleen

Digestive system Tongue, salivary glands, stomach, intestine (duodenum, jejunum, ileum), caecum, colon, liver, pancreas

Adipose tissue Mesenteric adipose tissue, peri-gonadal adipose tissue, Perirenal adipose tissue, brown adipose tissue

Urogenital system Kidneys, bladder, prostate, testes, seminal vesicle, ovaries, uterus

Cardiopulmonary system Lungs, heart, aorta

Other: skin, bones, muscle, eyes...

Products Species and characteristics of the models Price in Euros

Other biological materials Technical sheet available on www.janvier-labs.com

Urine (rat, mouse)

All speciesOn request

Feces

Milk (rat, mouse)

Amniotic fluid

Cerebrospinal fluid Rats


LABORATORY SERVICES

23

Surgery

Experimental protocols

* infusion onlyThe weight of the animal required on the order form corresponds to the weight at the moment of the operation.The price of the animal, the preparation before or after the operations and the treatments will be added to the price of the operation.

Services Species and characteristics of the models Price in Euros

Excision and ligature surgery Technical sheet available on www.janvier-labs.com

Ovariectomy

From 4 weeks of age On request

Ovario-hysterectomy

Hysterectomy

Splenectomy

Vasectomy

Castration

Adrenalectomy

70% hepatectomy (rat, mouse)

Nephrectomy (unilateral or 5/6)

Tubal ligation

Ureter ligation

Other types of ligation

Catheterisation Technical sheet available on www.janvier-labs.com

Non-vascular catheters:

Rats with a minimum weight of 200 g,

Pregnant female rats

(from day 9-10),

Mice (jugular and non-vascular catheters on the digestive tract)

On request

Bile duct

Stomach*, duodenum*, jejunum*, ileum*, colon*, intra-peritoneal* (injection)

Bladder*Vascular catheters:

Jugular veinFemoral veinCarotid arteryFemoral artery

Double vascular catheterDouble vascular / non-vascular catheter

Services (non-exhaustive list of protocols) Species and characteristics of the models Price in Euros

Customised protocols and models Technical sheet available on www.janvier-labs.com

Examples of protocols:DIO (Diet Induced Obesity) studies with different energy sources (lipids, carbohydrates, proteins...)

All species depending on the needs of the protocol

and its feasibilityOn request

Restricted diet studies

Inorganic or organic implant placement and subsequent monitoring including its evolution and its interaction with the animal

Pathological models Technical sheet available on www.janvier-labs.com

Examples of pathological experimental models:Surgery model: jaundice model in rat, osteoporosis model in rat by ovariectomy of females

All species On request

Substance injection model: arthritis model by Freund adjuvant injection, model of type II diabetes by streptozotocin injection in rats and mice

Diet-induced model: induced obesity by diet, hypercholesterolemia / atherosclerosis induced by high saturated fat and cholesterol diet, hypertriglyceridemia / insulin tolerance by high fructose / sucrose diet

TRANSPORT AND PACKAGING

over weekly

24

Animals are not used to being transported and this event can be a source of stress for them. This is why at JANVIER LABS, we have established an exclusive, strict transport policy, which is ISO 9001 certified and intended to limit this stress and protect the animals’ welfare during travel.

40 000 km

weekly deliveries with our in-house transport service

delivery by plane upon request

International routes

An in-house transport service

Stress management for animal transportation

// We have decided to provide this service in-house in order to reassure ourselves that it is carried out in a manner which meets our expectations.

All our delivery drivers have been trained in biosecurity and animal welfare; they achieved this by undergoing training in the transportation of live animals. They travel using our own fleet of 20 air-conditioned, ventilated lorries, specially equipped for the carriage of laboratory rodents and approved by the veterinary authorities. Some of our vehicles are also equipped with air-tight cases for the repatriation of non-SPF animals.

In order to minimise the animals’ stress during journeys, we have put appropriate measures in place, like driving on motorways and outsourced teams of drivers. Thanks to these measures the journeys are of a reduced length, without stops and more comfortable for the animals in order to guarantee optimal stability conditions for our models at the point of delivery.

We arrange for the reception and expedition of your animals and biological products all over the world and in the best possible health conditions.

Our transport service covers over 40,000 km every week and provides weekly deliveries throughout Europe.

Upon request we can arrange air transport to all other countries.

Packaging adapted to animal’s health status

Transport gel provided freeAll of our packaging contains a drink substitute to rehydrate the animals during transit. This product guarantees the preservation of the SOPF and SPF status.

25

TRANSPORT AND PACKAGING

Packaging (measurements) Price in Euros

Filterless packaging - small model (430 x 330 x 150 mm)

On request

Filterless packaging - large model (580 x 433 x 150 mm)

Filter packaging - small model (430 x 330 x 150 mm)

Filter packaging - large model (580 x 433 x 150 mm)

Easypack : IATA-certified packaging - small model

Easypack : IATA-certified packaging - large model

Packaging for catheterised animals

Dry ice packaging - large and small model

Refreeze packaging

Transport gel

Gelatine block - in bag (sold separately)

Weekly deliveries to the nordic countriesFlexibility, reactivity and reliability!

Denmark, Norway : place your orders up to noon on mondays the week of delivery.Finland, Sweden : place your orders up to fridays the week of delivery.

City / Country Day of delivery Price in Euros

Denmark Wednesday

On requestSouth and East of Sweden Wednesday

West of Sweden (Göteborg area) ThursdayNorway ThursdayFinland Thursday

GENERAL TERMS AND CONDITIONS OF SALE OF RESEARCH MODELS

PURPOSE

The general terms and conditions of sale herein apply to the sales of RESEARCH MODELS from strains developed by JANVIER LABS : rodents for biomedical research for scientific purpose, and any extra service, as described in JANVIER LABS catalogue, on its website (www.janvier-labs.com) and/or in quote, offer or any other equivalent document accepted by JANVIER LABS (the ORDER).Laboratory services, reproductive sciences, customized breeding and related services are expressly excluded from these general terms and conditions of sale.JANVIER LABS is a limited company under French law whose head office is at Le Genest-Saint-Isle (53940) – route des Chênes Secs – France, and registered at the Trade Register of Laval with the registration number 340 663 079.The general terms and conditions of sale are attached to JANVIER LABS catalogue, accessible on its website and provided by JANVIER LABS with each ORDER. JANVIER LABS may modify from times to times its general terms and conditions of sale.

FORMATION OF THE ORDER

1. JANVIER LABS may advise the customer during the ordering process. However, the customer is sole liable for its choice of the ORDER and JANVIER LABS may not be liable for the compatibility/adequacy of this choice to the research and/or therapeutic objectives sought by the customer.2. The ORDER is legally valid when expressly and in writing accepted by JANVIER LABS.The general terms and conditions of sale are part of the ORDER.The customer is deemed having accepted the general terms and conditions of sale provided with the ORDER.

EFFECT OF THE ORDER

Any other provision in contradiction with these general terms and conditions of sale shall be explicitly accepted in advance in writing by JANVIER LABS to apply.Should any provision of the general terms and conditions of sales herein be declared null and void or non written by the relevant authority, such a decision would not affect the validity of the remaining provisions.The fact of not asserting a prerogative by one party does not mean that this party waives implicitly or explicitly his right.The customer is liable for enforcing these terms and conditions of sale by its employees and any third party collaborating in research conducted under the authority of the customer or in which the customer participates.

MODIFICATION / CANCELLATION OF THE ORDER

In case of modification/cancellation of ORDER, the customer should pay penalty fees (percentage) calculated of the net amount of RESEARCH MODELS concerned and depending on the delay between the planned delivery date and the modification and/or cancellation request, as follows:For ORDER of RESEARCH MODELS non mutant and less than 3 months, mentioned in JANVIER LABS catalogue :Between 28 and 22 days : 10%Between 21 and 15 days : 25%Between 14 and 8 days : 50%Between 7 and 3 days : 75%Less than 3 days : 100%For ORDER of RESEARCH MODELS non mutant and/or between 3 and 18 months, mentioned in JANVIER LABS catalogue :Between 28 and 22 days :10%Between 21 and 15 days : 25%Between 14 and 8 days : 75%Less than 8 days : 100% For ORDERS of RESEARCH MODELS 19 months old and over 19 months old, mentioned in JANVIER LABS catalogue: Over 30 days : 50%30 days and less than 30 days : 100%For any other ORDER not listed in JANVIER LABS catalogue, penalty fees should represent 100% of the net amount of the RESEARCH MODELS concerned, regardless the date of the modification/cancellation.

TRANSPORT

The transfer of risk and property of the RESEARCH MODELS takes place on the premises of JANVIER LABS, by their direct delivery to the customer or to the third person designated by the customer.When JANVIER LABS carries out transport of the RESEARCH MODELS, the transfer of risk takes place at the place of delivery designated by the customer.

PRICE

The price of the RESEARCH MODELS and extra services are mentioned in the ORDER.The prices of RESEARCH MODELS are taken to be in unit measures excluding duties, taxes, packaging and transport. These extra fees, including any variation of these fees between the ORDER and the billing, are charged to the customer.JANVIER LABS list prices are revised each year with effect from January 1st.

PAYMENT

1. Unless mentioned otherwise, invoices are payable in Euros, by bank transfer respecting the receiving bank details indicated by JANVIER LABS, to the order of JANVIER LABS’ head office, situated at Route des Chênes Secs – 53940 Le Genest Saint Isle – France, within 30 days following the end of the month of the invoice date. No discount will be awarded by JANVIER LABS in respect of immediate payment or payment within a shorter delay than the one indicated on the ORDER or invoice.The customer may not clear the invoice.2. In the case of non-payment of an invoice at its due date, JANVIER LABS reserves the right to suspend all future deliveries and/or demand immediate payment for all ORDERS in progress or to come.Any payment made after the due date will lawfully incur a late payment charge to be added to the sums due, calculated according to the interest rate applied by the European Central Bank at its most recent refinancing operation (on 1st January for the 1st semester, to 1st July for the 2nd semester), plus 10% and calculated by indivisible periods of 15 days commencing from the first day of the late payment. The customer shall also pay a set fee of € 40 per unpaid invoice to participate towards fees engaged to recover the non-payment, without affecting the rights of JANVIER LABS to claim further compensation should the recovery expense exceed the previously mentioned amount.

CONFORMITY – GUARANTEE

1. JANVIER LABS guarantees having the administrative titles/certificates required to carry out its activity.From its side, the customer is liable for regularity of its protocols of research, and the use of the RESEARCH MODELS towards its applicable law.

JANVIER LABS guarantees the RESEARCH MODELS comply with the ORDER.2. JANVIER LABS carries out a regular health control of its strains. Methods and results are available on its website or on request. JANVIER LABS delivers to the customer, upon delivery of the RESEARCH MODELS, a health certificate corresponding to the status SPF or SOPF, defined by JANVIER LABS and chosen by the customer at the ORDER. In any case, this certificate does not relieve the customer from applying its own biosecurity rules and ensuring its own health program.Upon receipt of the RESEARCH MODELS, the customer checks conformity and any reserve shall be specified on the transport receipt.For health reasons, no return of RESEARCH MODELS can be realized.Any allegation of non-compliance must be submitted in writing to JANVIER LABS within a maximum of 3 months from receipt of the RESEARCH MODELS.The customer must allow JANVIER LAB to carry out the appropriate verifications if it considers it necessary, including the customer’s site visits, with JANVIER LABS experts.In any event, when the customer discovers any abnormality, he should immediately take the appropriate measures to limit its aggravation or dispersion.3. The weight and/or age of RESEARCH MODELS is weight and/or age at the date of packing.For gestating females:- JANVIER LABS guarantees the animals according to the specific conditions for each strain as presented in JANVIER LABS catalogue,- JANVIER LABS neither guarantees the number of animals per gestation, nor the exact date of giving birth.- JANVIER LABS does not guarantee the risk of interruption of gestation during transit if the gestation period is either less than 5 days or more than 2/3 of the gestation period, from the shipment of pregnant females.4.The customer is not allowed to transfer the JAX™ Sperm Cryo Kit (JAX is a trademark of The Jackson Laboratory registered in the United States. All rights reserved.) bought to JANVIER LABS out of the territory of JANVIER LABS license, corresponding to France, Austria, Belgium, Czech Republic, Germany, Hungary, Italy, The Netherlands, Poland, Slovakia, Spain, Switzerland, Denmark, Sweden, Norway, Finland.

PROPERTY

1. The rodent strains mentioned in JANVIER LABS catalogue are its property or under its control.2. The customer shall use the RESEARCH MODELS exclusively for its internal research under its control.The customer shall not transfer the RESEARCH MODELS with a financial counterpart.Any transfer of RESEARCH MODELS shall be accepted in advance in writing by JANVIER LABS and (i) the transfer shall be without any financial counterpart for the customer, (ii) the RESEARCH MODELS shall be used exclusively for a considered research project lead under the authority of the customer, and (iii) the rules of the MGI nomenclature shall be respected.3. Any information, data or protocol transferred by JANVIER LABS to the customer is the property and/or under the control of JANVIER LABS. The customer gets only the right to use them, after the complete payment of the RESEARCH MODELS and exclusively to use the RESEARCH MODELS in accordance with the provisions (2) above.

RESPONSABILITY

The liability of JANVIER LABS, whatever its nature and its form, is limited to definite, direct and material damage in the limit of the net before tax amount of the corresponding disputed ORDER. JANVIER LABS cannot in any circumstance be held to indemnify the customer for lost of income, chance or opportunity and more generally, immaterial and/or indirect damage suffered by the customer.JANVIER LABS may not be liable for decisions from the customer or any third party.

FORCE MAJEURE

JANVIER LABS cannot be held responsible for the non-respect of its obligations in the case of force majeure. In particular, the following are considered cases of force majeure : difficulties in production or transport due to bad weather, acts of war, partial or total strikes, terrorism, legal authority decision.

INSURANCE

Each party undertakes to get and keep an insurance policy to cover its professional civil liability with a notoriously solvent insurance company.

CONFIDENTIALITY

Any information, data, protocol provided by JANVIER LABS to a customer in the course of the formation or the execution of an ORDER are considered as confidential.Any communication by the customer to a third party shall be accepted in advance in writing by JANVIER LABS, who may not refuse except for just cause.Without granting any right or license, the non disclosure obligation does not apply to information (i) that is or becomes, through no improper action or inaction by the customer, generally available to the public; or(ii) in the possession of the customer or known by the customer prior to receipt from JANVIER LABS as evidenced in writing, except to the extent that such information was unlawfully appropriated; or (iii) was rightfully disclosed to the customer by a third party; or (iv) ordered to be released by the requirement of a government agency.This obligation is valid during the execution of the ORDER and for 5 years from the execution of the ORDER.

RESOLUTION

An ORDER may be resolved by the party victim of the non execution of an obligation by the faulty party, if no reasonable solution has been offered by the faulty party within 30 days from the reception of a signed-for letter notifying the circumstances, the nature an the extent of the default.Notwithstanding the resolution of an ORDER, the provisions concerning conformity-guarantee, property, confidentiality, responsibility, applicable law-jurisdictional competence will keep to apply whatever the reason of the resolution.

APPLICABLE LAW - JURISDICTIONAL COMPETENCE

Any question relative directly or indirectly to an ORDER or to the general sales terms and conditions of sale are governed by French law.When JANVIER LABS and the customer fail to reach an amicable arrangement concerning a dispute relative directly or indirectly to an ORDER or to the general terms and conditions of sale, the dispute shall be submitted to the exclusive competence of the commercial court (Tribunal de commerce) in Laval - France, even in the event of multiple proceedings or parties or the use of a substitute representative.* * *

26

GENERAL TERMS AND CONDITIONS OF SALE OF RESEARCH MODELS

JANVIER LABS SAS au capital de 194 992,00 € - RCS LAVAL 340663079 - FR 62340663079 Route des Chênes Secs 53940 LE GENEST SAINT ISLE 27

PURPOSE

The general terms and conditions of sales herein apply to the provision of SERVICES by JANVIER LABS: laboratory services, reproductive sciences, customized breeding, and any extra services, performed from the biological material provided by the customer or a third party on customer request (the BIOLOGICAL MATERIAL) and correspond to rodents for biomedical research for scientific purpose. The SERVICES are described in JANVIER LABS catalogue, on its website (www.janvier-labs.com) and/or in quote, offer or any other equivalent document accepted by JANVIER LABS (the ORDER).The sales of research models developed from strains belonging or under the control of JANVIER LABS and related sales are expressly excluded from these general terms and conditions of sale.JANVIER LABS is a limited company under French law whose head office is at Le Genest-Saint-Isle (53940) – route des Chênes Secs – France, and registered at the Trade Register of Laval with the registration number 340 663 079.The general terms and conditions of sale are attached to JANVIER LABS catalogue, accessible on its website and provided by JANVIER LABS with each ORDER. JANVIER LABS may modify from times to times its general terms and conditions of sale.

FORMATION OF THE ORDER

1. JANVIER LABS may advise the customer during the ordering process. However, the customer is sole liable for its choice of the ORDER.2. JANVIER LABS provides to the customer a quote for each SERVICE, with the general terms and conditions of sales. The customer shall provide in advance to JANVIER LABS any information he gets concerning the BIOLOGICAL MATERIAL.The BIOLOGICAL MATERIAL shall correspond to class 1, excluding all other category of risk, and free of zoonoses.These information (including the Project Information Form), and the general terms and conditions of sale are part of the ORDER.The ORDER is legally valid when expressly and in writing accepted by JANVIER LABS following the quote accepted by the customer and/or a corresponding order form by the customer.The acceptance of the quote or the corresponding order form corresponds also to the acceptance of the general terms and conditions of sales. In the case whereby the SERVICE necessitates an approval from the French State ministry of Higher Education and Research (MESR), the validity of the ORDER shall be suspended until JANVIER LABS gets the approval from the MESR to provide such SERVICE.

EFFECT OF THE ORDER

Any other provision in contradiction with these general terms and conditions of sale shall be explicitly accepted in advance in writing by JANVIER LABS to apply.Should any provision of the general terms and conditions of sales herein be declared null and void or non written by the relevant authority, such a decision would not affect the validity of the remaining provisions.The fact of not asserting a prerogative by one party does not mean that this party waives implicitly or explicitly his right.The customer is liable for enforcing these terms and conditions of sale by its employees and any third party collaborating in research conducted under the authority of the customer or in which the customer participates.

MODIFICATION / CANCELLATION OF THE ORDER

In case of modification/cancellation of ORDER, the customer should pay the part of the SERVICES performed, any expenses engaged by JANVIER LABS for the SERVICES and non cancellable, and any other indirect expenses for JANVIER LABS because of the modification/cancellation of ORDER.

BACKUP

Before the transfer of the BIOLOGICAL MATERIAL, the customer must make a backup of the corresponding line, until confirmation by JANVIER LABS of the realization of the laboratory service or reproductive sciences service or, for the customized breeding, until the delivery to the customer of the first cohort of animals.

TRANSPORT

Picking up of the BIOLOGICAL MATERIAL:The customer is responsible for the preparation, packaging, and labeling of packages in accordance with applicable regulations on all transit conditions.The customer must provide all the information and documents required by JANVIER LABS or the carrier, within a maximum of 5 days prior to the picking up of the BIOLOGICAL MATERIAL.Delivery of the results of the SERVICES:The transfer of the risks relating to the results of the SERVICES takes place on the premises of JANVIER LABS, by their direct delivery to the customer or to the third person designated by the customer.When JANVIER LABS carries out transport of the results of the SERVICES, the transfer of the risks takes place at the place of delivery indicated by the customer.

PRICE

The price of the SERVICES and related services are mentioned in the ORDER.The prices of SERVICES are taken to be in unit measures excluding duties, taxes, packaging and transport. These extra fees, including any variation of these fees between the ORDER and the billing, are charged to the customer.The price in the ORDER is set out for a period and/or a volume and/or a capacity agreed between JANVIER LABS and the customer.JANVIER LABS list prices are revised each year with effect from January 1st.

PAYMENT

1. Unless mentioned otherwise, invoices are payable in Euros, by bank transfer respecting the receiving bank details indicated by JANVIER LABS, to the order of JANVIER LABS’ head office, situated at Route des Chênes Secs – 53940 Le Genest Saint Isle – France, within 30 days following the end of the month of the invoice date. No discount will be awarded by JANVIER LABS in respect of immediate payment or payment within a shorter delay than the one indicated on the ORDER or invoice.The customer may not clear the invoice.2. In the case of non-payment of an invoice at its due date, JANVIER LABS reserves the right to suspend all future deliveries and/or demand immediate payment for all ORDERS in progress or to come.Any payment made after the due date will lawfully incur a late payment charge to be added to the sums due, calculated according to the interest rate applied by the European Central Bank at its most recent refinancing operation (on 1st January for the 1st semester, to 1st July for the 2nd semester), plus 10% and calculated by indivisible periods of 15 days commencing from the first day of the late payment.

The customer shall also pay a set fee of € 40 per unpaid invoice to participate towards fees engaged to recover the non-payment, without affecting the rights of JANVIER LABS to claim further compensation should the recovery expense exceed the previously mentioned amount.

CONFORMITY – GUARANTEE

1. JANVIER LABS guarantees having the administrative titles/certificates required to carry out its activity.From its side, the customer is liable for regularity of its activity, the BIOLOGICAL MATERIAL and its protocols of research in accordance with its applicable law. 2. JANVIER LABS guarantees the SERVICES comply with the ORDER.JANVIER LABS is bound by an obligation of means and can not be responsible for insufficient or erroneous information regarding the composition and characteristics of the BIOLOGICAL MATERIAL.3. JANVIER LABS carries out a regular health control, whose methods and results are available on its website or on request. JANVIER LABS delivers to the customer, to the delivery of the animals resulting from the SERVICE BENEFITS, a health certificate corresponding to the status SPF or SOPF, defined by JANVIER LABS and chosen by the customer with the ORDER.In any case, this certificate does not relieve the customer from applying its own biosecurity rules and ensuring its own health program.4. Upon receipt of the results of the SERVICES, the customer carries out a conformity control. Any reserve shall be specified on the transport receipt. For health reason, no return of the results of the SERVICES can be realized.In the event of an anomaly, the customer must immediately take all necessary measures to prevent the aggravation and/or spread of this anomaly.The customer informs JANVIER LABS of any anomaly within 3 working days of the discovery of the anomaly.The customer must allow JANVIER LAB to carry out the appropriate verifications if it considers it necessary, including the customer’s site visits, with JANVIER LABS experts.

PROPERTY

1. The customer declares having the necessary rights and titles to provide the BIOLOGICAL MATERIAL to JANVIER LABS to carry out the SERVICES.JANVIER LABS acquires no rights in the BIOLOGICAL MATERIAL, its descendants and derivatives. JANVIER LABS undertakes to use them exclusively within the framework of the ORDER.2. Any method, protocol, know-how implemented during the execution of the SERVICES and developed by JANVIER LABS or by a third party previously to the performance of the SERVICES, are and remain the exclusive property respectively of JANVIER LABS or this third party.Upon full payment of the SERVICES, the customer shall have the right to use the information provided by JANVIER LABS for its internal needs related to the use of the results of the SERVICES, without any other possibility of exploiting them, in particular reproduction and/or sales.

RESPONSABILITY

The liability of JANVIER LABS, whatever its nature and its form, is limited to definite, direct and material damage in the limit of the net before tax amount of the corresponding disputed ORDER. JANVIER LABS cannot in any circumstance be held to indemnify the customer for lost of income, chance or opportunity and more generally, immaterial and/or indirect damage suffered by the customer.JANVIER LABS may not be liable for decisions from the customer or any third party.

FORCE MAJEURE

JANVIER LABS cannot be held responsible for the non-respect of its obligations in the case of force majeure. In particular, the following are considered cases of force majeure : difficulties in production or transport due to bad weather, acts of war, partial or total strikes, terrorism, legal authority decision.

INSURANCE

Each party undertakes to get and keep an insurance policy to cover its professional civil liability with a notoriously solvent insurance company.

CONFIDENTIALITY

Any information, data, protocol provided by JANVIER LABS to a customer in the course of the formation or the execution of an ORDER are considered as confidential.Any communication by the customer to a third party shall be accepted in advance in writing by JANVIER LABS, who may not refuse except for just cause.Without granting any right or license, the non disclosure obligation does not apply to information (i) that is or becomes, through no improper action or inaction by the customer, generally available to the public; or(ii) in the possession of the customer or known by the customer prior to receipt from JANVIER LABS as evidenced in writing, except to the extent that such information was unlawfully appropriated; or (iii) was rightfully disclosed to the customer by a third party; or (iv) ordered to be released by the requirement of a government agency.This obligation is valid during the execution of the ORDER and for 5 years from the execution of the ORDER.

RESOLUTION

An ORDER may be resolved by the party victim of the non execution of an obligation by the faulty party, if no reasonable solution has been offered by the faulty party within 30 days from the reception of a signed-for letter notifying the circumstances, the nature an the extent of the default..Notwithstanding the resolution of an ORDER, the provisions concerning conformity-guarantee, property, confidentiality, responsibility, applicable law-jurisdictional competence will keep to apply whatever the reason of the resolution.

APPLICABLE LAW - JURISDICTIONAL COMPETENCE

Any question relative directly or indirectly to an ORDER or to the general sales terms and conditions of sale are governed by French law.When JANVIER LABS and the customer fail to reach an amicable arrangement concerning a dispute relative directly or indirectly to an ORDER or to the general terms and conditions of sale, the dispute shall be submitted to the exclusive competence of the commercial court (Tribunal de commerce) in Laval - France, even in the event of multiple proceedings or parties or the use of a substitute representative.

* * *

GENERAL TERMS AND CONDITIONS FOR THE PROVISION OF SERVICES

T. +33 (0)2 43 02 11 91F. +33 (0)2 43 02 00 [email protected]

CS 4105 - Le Genest-Saint-Isle F-53941 Saint-Berthevin Cedex

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