Prezentace aplikace PowerPoint - Univerzita Karlovaanat.lf1.cuni.cz/souhrny/alekzs1402.pdfCell...
Transcript of Prezentace aplikace PowerPoint - Univerzita Karlovaanat.lf1.cuni.cz/souhrny/alekzs1402.pdfCell...
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http://diogenesii.files.wordpress.com
Metchnikoff EhrlichKochPasteurhttp://www.iemrams.spb.ru http://www.wired.com http://media-2.web.britannica.com
Founders
Immune-lymphatic system
Pavel Šnajdr Karel Smetana
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10% of interstitial fluid forms lymphatic fluid
Immune-lymphatic system = primary + secondary organsprimary:bone marrow, thymussecondary: lymph. nodes, spleen, tonsils, aggregates (MALT=BALT+GALT)
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10% of interstitial fluid forms lymphatic fluid
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only limited no. of tissue without lymphatics .…hair, epidermis, cornea, vitreous body, lens, cartilage, nervous tissue, bone marrow ?
lymphatics
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Lymphatic tissue represents a morphological substrate for the majority of immune reactions. Main components are originated from the pluripotent haematopoietic stem cell that is located in bone marrow- the most important primary lymphoid organ.
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http://www.lifeethics.org
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Neutrophil leukocytes and monocytes/macrophages are participating in innate (natural) immune repsonse. Lymphocytes (T/B) are the main representatives of the acquired (specific or adaoptive) immunity.
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Monocytes
T-lymphocytes
B-lymphoocyteshttp://www.medicalmediakits.com
http://missinglink.ucsf.edu
http://www.cartage.org.lb
www.jbc.org
Neutrophil granulocytes
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Professional antigen-presenting dendritic cells represent a highly efficient chain of specific immune response. These elements are located in epithelia of body surfaces. They migrate to lymphatic nodes where they „teach“ theT-lymphocytes.
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Langerin
Human epidermis
Dendritic cells in epidermis (Langerhans cells)
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Cell interaction in immune system
www.microbiologybytes.com
Antigen presentation needs a complicated molecular crosstalk between surface molecules of antigen presenting cells and lymphocytes.
MHC–major histocompatibility complex(mouse) = HLA-human leukocyte antigens-specialized proteins on the surface of APC
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Lymphocytes specifically activated by professional antigen-presenting cells participate not only in antiinfectious immunity but they are also important in anticancer immunological surveillance. They can be used in preparation of anticancer vaccines.
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CD8-positive toxic T-lymphocytes destroy cancer cells
www.dkfz.de
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Sup. mediastinum
• Involution of thymus
Thymus (brzlík)
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Thymus is primary lymphatic organ with a key role in the control of the differentiation of naive lymphocytes to the form of T-lymphocytes. Thymus is originated in embryonic pharynx. It is located in anterior mediastinum. Thymus is involuted during the postnatal development. It is free from the lyphatic afferents.
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www.wsahs.nsw.gov.au http://www.ehponline.org
Origin of thymus
3rd pharyngeal pouch -process of migration (descent)
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Ectopic thymic and parathyroid tissue
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Thymus – stromal cells+developing T cells
several incomplete lobulescapsule -trabeculaecortex with developing T-cells medulla with Hassall´s corpuscles
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hilum
aff. et eff. vessels
capsula , trabeculae
sinuses –
Cortex - folliculi paracortex, medulla
lymphonode
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Spleen
home.comcast.net
http://www.isradiology.org/
www.szote.u-szeged.hu
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The spleen (lien) is one of the most important secondary lymphatic organs. It is located in abdoinal cavity. In addition to immune function it is reponsible for destruction of old erythrocytes. The hematopoiesis was prenataly located in the spleen.
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Spleen
mednote.co.kr
http://altered-states.net
Stroma consists of:white pulp=central arteriole + PALS+ corona (B, T cells)red pulp=sinusoids and cords
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Spleen (12x )
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Lesser peritoneal cavity (Bursa omentalis)
Epiploic foramen
F. H. Netter: Anatomický atlas člověka. Grada/Avicenum, Praha, 2003
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19
20
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Lymphatic nodes are also the secondary lyphatic otrgan. They are included into the lymphatic vessels. The represent a site of active antigen presentation. Both T/B lymphocytes are actively proliferating inside the lymph nodes in course of immune reaction.
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hilum
aff. et eff. vessels
capsula , trabeculae
sinuses –
Cortex - folliculi paracortex, medulla
Lymphatic node
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Lymphatic node
http://lymphaticmassagenyc.com http://education.vetmed.vt.edu
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Lymphatic node (x 8)
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Follicle with germinal centre and mantle (x 50)
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http://img.medscape.com
http://www.clarian.org/
Method of sentinel node decreases an occurrence of complications connected with radical surgery of of breast cancer such as a lympoedema.
http://lymphedemaville.wordpress.com/
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Lymphatic tissue is accumulated in the wall of internal organs that are in contact with factors of macroenvironment (for example digestive or respiratory system).
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MALT (Mucosa associated lymphatic tissue)
http://www.nature.com
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Appendix vermiformis
http://www.anatomie.net
http://www.mghradrounds.org/
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Accumulation of lymphatic tissue in the specific sites of oro/nasopharynx: tonsils
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Tonsila palatina-origin
Sadlet TW: Langmanova lékařská embryolopgie, Grada, 2011, Praha
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http://www.dentalarticles.com/images/throat-tonsils.jpeg
Lamphatic circle of Waldeyr
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Tonsila palatina
www.udel.edu
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Tonsila lingualis
anatomyatlases.org
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Tonsila pharyngea
http://www.esg.montana.edu
http://www.mzhelal.com
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thoracic d., right lymph. tr, jugular tr., subclavian tr., bronchomediastinal tr., intestinal tr., lumbar tr.
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Lymphatic nodes of the head occipital, retroauricular, parotid,
submental submandibular
Superficial cervical -anteriores –along AJV-laterales – along EJV-posteriores – along n XI
Deep cervical- along IJVKüttner´s-jugulodigastricKocher¨s- juguloomohyoid
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breast cancer9% of female population
clinical examination: palpation, ultrasound, mammografy
importance of its lymphatic drainage !!!
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axillary nodes pectoral (Sorgius) subscapular interpectoral lateral central apical (infraclavicular)
parasternal nodes
supraclavicular nodes
abdominal connections (alongside epigastric vessels)
subareolar plexus, circumareolar plexus
L CA
SC
PS
P
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lymphoedema of upper limb after breast cancer surgery (axillary lymphonodes removal is an unavoidale part of the procedure)
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axillary nodes
spf. et deep inguinal lymph. nodes lower limb+ext. genital, lower third of vagina, anal part of rectum recti
lymphatic drainage of upper limb
lymphatic drainage of lower limb
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pulmonary nodes
bronchopulmonary nodes
sup. et inf. tracheobronchial nodes
paratracheal nodes
bronchomediastinal tr.
ant. mediastinal nodes post mediastinal nodes
lymphatic drainage of lungs
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gastric, pyloric, pancreaticolienal pancreaticoduodenal hepatic mesenteric colic et paracolic rectal et pararectal
lymphatic drainage of GIT
nodes
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lumbar comm. iliac ext. iliac int. iliac - parauterine (Bayer) / retroprostatic
lymphatic drainage of genitals
nodes