Invasive pressure monitoring saves from tuberculous meningitis with
Prevnar.ppt meningitis, ottitis media, invasive disease
-
Upload
richin-koshy -
Category
Documents
-
view
78 -
download
1
Transcript of Prevnar.ppt meningitis, ottitis media, invasive disease
Prevnar 13™
Pneumococcal 13-valent conjugate vaccine
Manufacturer: Wyeth
FDA Approval Date: 12/2011
Prevnar 13™ - Pneumococcal 13-valent conjugate
Clinical Application
• Indications:• Immunization of infants and children against Strep
pneumoniae caused by included serotypes• Immunization of infants and children against otitis
media caused by Strep pneumoniae serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F
• Immunization of adults ≥50 years against pneumococcal pneumonia and invasive disease caused by included Strep pneumoniae serotypes
Prevnar 13™ - Pneumococcal 13-valent conjugate
Clinical Application
• Place in therapy:• Vaccination used to immunize patients as young
as 6 weeks against various strains of Strep pneumoniae
Prevnar 13™ - Pneumococcal 13-valent conjugate
Clinical Application
• Contraindications:
• Hypersensitivity
• Warnings:
• Apnea and Acute Illness
• Precautions:
• Use in pts w/ altered immunocompetence
• Use in Elderly (>65yoa)
Prevnar 13™ - Pneumococcal 13-valent conjugate
Clinical Application
• Pregnancy:• B
• Lactation:• Excretion in breast milk unknown/use caution
Prevnar 13™ - Pneumococcal 13-valent conjugate
Drug Facts
• Pharmacology
• Administered as a series of 4 injections given at 2, 4, 6, and 15-18 months of age
• Full efficacy w/in 1 month of the final vaccination
Prevnar 13™ - Pneumococcal 13-valent conjugate
Drug Interactions
• Drug Interactions – Precipitant Drugs
• Belimumab: May the therapeutic effect of this Vaccine (inactivate)
• Fingolimod: May the therapeutic effect of this Vaccine (inactivate)
Prevnar 13™ - Pneumococcal 13-valent conjugate
Adverse Effects
• Common Adverse Effects: (>10%)
• Central nervous system: Chills, drowsiness, fatigue, fever, headache, insomnia, irritability
• Dermatologic: Rash• Gastrointestinal: Appetite decreased• Local: Erythema, limitation of arm motion,
pain, swelling, tenderness• Neuromuscular & skeletal: Arthralgia, myalgia
Prevnar 13™ - Pneumococcal 13-valent conjugate
Monitoring Parameters
• Efficacy Monitoring• None
• Toxicity Monitoring• None
Prevnar 13™ - Pneumococcal 13-valent conjugate
Prescription Information
• Dosing:• Infants and Children 6 weeks-59 months: 0.5 mL/dose X
4 doses:• The first dose may be given as young as 6 weeks - 2 months.
• The 3 remaining doses are usually given at 4, 6, and 12-15 months
• The recommended dosing interval is 4-8 weeks
• The minimum interval between doses in children <1 year of age is 1 month
• The minimum interval between the third and fourth dose is 2 months
• Cost: Estimated $430 for complete series
Prevnar 13™ - Pneumococcal 13-valent conjugate vaccine Summary
• Prevnar 13™ is the successor to the previously-marketed Prevnar® and is used in patients as young as 6 weeks.
• Prevnar 13™ contains an additional 6 serotypes of Streptococcus pneumoniae, compared to the 7 serotypes provided in the original Prevnar® formulation.
• The CDC has announced that young children appear to be at increased risk of febrile seizures when given the pneumococcal conjugate vaccine (PCV 13) at the same time as the inactivated influenza virus vaccine (TIV). The risk appears to be greatest from ages 12-23 months. Because febrile seizures are typically benign and occur in 2% to 5% of all young children, the ACIP does not recommend a delay in administration of either vaccine or altering the vaccine schedule in any manner due to the potential risk of infection.
Prevnar 13™ - Pneumococcal 13-valent conjugate
References
1. Prenvar-13 package insert. Wyerth Pharmaceuticals. Jan. 2012. http://labeling.pfizer.com/showlabeling.aspx?id=501
2. Pubmed. MMWR Recomm Rep. 2010 Dec 10;59(RR-11):1-18. Accessed 01/12. http://www.ncbi.nlm.nih.gov/pubmed/21150868