PREVIEW OF BEST PRACTICES IN PATIENT · PDF fileIntroduction Introduction FACILITATORS &...

BEST PRACTICES IN PATIENT RECRUITMENT A U G U S T , 2 0 1 6

P R E V I E W O F

BEST PRACTICES IN

REPORT OVERVIEW

WHAT YOU WILL LEARN

How you can use this report

Patient recruitment is a primary concern of the clinical trial industry. Every day that a clinical trial goes beyond its intended deadline the sponsor organization could lose hundreds of thousands to millions of dollars in sales. Sponsors, CROs, and sites engage various means to reach key milestones on time and within budget. To provide the best perspective on this critical topic, ISR gathered opinions from key decision-makers at three different types of stakeholder organizations: sponsors, CROs, and sites. Further, we explored the increasingly important role of specialized patient recruitment firms by examining their market penetration, value, and performance.

D A T A C O L L E C T I O N I N Q 1 , 2 0 1 6

2 0 - M I N U T E W E B - B A S E D

S U R V E Y

1 0 3 R E S P O N D E N T S F R O M S P O N S O R S , C R O S A N D S I T E S

210 PAGES

304 CHARTS AND

GRAPHS

VALUABLE FOR

• Which entity (sponsor, CRO or site) has the greatest potential to impact patient recruitment success and why

• Key drivers to successful patient recruitment, including which study characteristics impact participation

• Respondents’ insight into their approach to recruiting for a global trial, including country selection factors and challenges for which to be prepared

• Know when and how to engage a specialized patient recruitment firm to get the best value

• Understand the value of various patient recruitment tactics and the best sources for recruiting patients

• Employ best practices identified by industry peers to improve the likelihood your clinical trial will be completed on-time and within budget

FOR PHARMA

FOR SERVICE PROVIDERS

Shortlist strong performing CROs and Specialized Patient Recruitment Firms for future patient recruitment needs

Benchmark your company against the competition in terms of meeting client expectations, satisfaction, and quality

Introduction

SMARTER QUESTIONS SMARTER ANSWERS

CLINICAL OPERATIONS CLINICAL DEVELOPMENT

EXECUTIVE MANAGEMENT PATIENT RECRUITMENT

INVESTIGATORS & SITE MANAGERS

THERAPEUTIC AREA HEADS

SITE RESEARCH COORDINATORS

SITE PRINCIPAL INVESTIGATORS

Full Table of Contents on next page.

MAJOR SECTIONS:1. Facilitators & Barriers

to Patient Recruitment Success

2. Specialized Patient Recruitment Firms Market Overview

3. CRO Performance Ratings on Patient Recruitment

4. Study Data

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Introduction


COPYRIGHT AND USAGE GUIDE

INTRODUCTION

METHODOLOGY

PARTICIPANT CRITERIA

FACILITATORS & BARRIERS TO PATIENT

RECRUITMENT SUCCESS

Primary Findings

Which entity has the greatest

impact on recruitment success?

Recruitment success

drivers — unprompted

Recruitment success

drivers — prompted

Value of recruitment tactics

Current and future patient

recruitment tactics

Sponsors

CROs

Sites

Recruiting patients for

global programs

Patient recruitment challenges in

global clinical trials — unprompted

Global trial country

selection factors

SPECIALIZED PATIENT RECRUITMENT

FIRMS MARKET OVERVIEW

Primary Findings

Source of patients recruited

Sponsors

Specialized patient recruitment

firm usage

Utilization strategies

Importance of specialized patient

recruitment firm services


firms provide more value than

adding sites

Specialized patient recruitment firm

use by company

Sponsors

CROs

Sites

Specialized patient recruitment firm

performance ratings

Sponsors

CROs

Sites


firm scorecards

Budget

Capabilities

Timing

Scorecard performance summary

Quality index performance ratings

CRO PERFORMANCE RATINGS

ON PATIENT RECRUITMENT

Primary Findings

CRO patient

recruitment scorecards

Budget — sponsors

Capabilities — sponsors

Timing — sponsors

Capabilities — sites

Timing — sites

Quality index performance ratings

Sponsors

Sites

STUDY DATA

Entity with the most power to

impact recruitment success

Recruitment success

drivers – unprompted

Recruitment success

drivers – prompted

Recency of using patient

recruitment services

Sponsors

Sites

Patient recruitment services

meeting expectations

Sponsors

Sites

Recruitment vendor structure for

global programs

Challenges faced in recruiting

patients into global clinical

trials – unprompted

Global trial country

selection factors

Value of recruitment tactics

Sponsors

CROs

Sites

Current and future patient

recruiting tactics

Sponsors

CROs

Sites

Source of patients recruited

Sponsors

Specialized patient recruiting

firm use

Sponsors

CROs

Sites


firm performance

Sponsors

CROs

Sites

Value of specialized patient

recruitment firms’ recruiting efforts

Sponsors

CROs

Sites

Strategies for specialized patient

recruitment firm use

Importance of specialized patient

recruitment services

Sponsors

CROs

Sites

Most important aspects of

specialized patient recruitment

firm services


firms offer more value than

additional sites

CRO PATIENT RECRUITMENT

DRILL-DOWNS

Accell

Accelovance

Accenture

BioClinica

Bioskin

Celerion

Chiltern (including Theorem)

Clinical Research Services (CRS)

Clinipace

Clinlogix

TABLE OF CONTENTS


Introduction


Clinsys

Cognizant

Covance

DaVita Clinical Research

DCRI-Duke

Encorium

Eurofins

Eurotrials

Frontage

HungaroTrial

ICON

Inamed

INC Research

inVentiv Health Clinical

KCR

Lambda

Medpace

Medsource

NAMSA

Novotech

PAREXEL

Pharm-Olam International

PPD

PRA

Premier Research

ProTrials

QPS

Quintiles

Rho

SanaClis

SGS Life Sciences

Southern Star

SPRI Clinical Trials

Symbio

SynteractHCR

Tata

TKL Research

West Coast Clinical Trials

Worldwide Clinical Trials

SPECIALIZED PATIENT RECRUITMENT

FIRM DRILL-DOWNS

Academic Network (a

Stericycle company)

Acurian (a PPD company)

BBK Worldwide

CAHG Trials

Clariness

Clinical List America

Clinical Site Services

Clinical Trial Media

DAC Patient Recruitment Services

MediciGlobal

MMG

PatientsLikeMe

Patient Recruiters International

Praxis Communications

Resolutions Rapid

Enrollment Solutions

Synexus

The Patient Recruiting Agency

Threewire

RESPONDENT PROFILE

Organization type

Responsibilities

Interaction with functions

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RESEARCH

304CHARTS

AND GRAPHS

SAMPLE PAGES

TABLE OF CONTENTS


Introduction


Introduction

FACILITATORS & BARRIERS TO PATIENT RECRUITMENT SUCCESS

Best Practices in Patient Recruitment 18www.ISRreports.com ©2016

Sponsors and CROs differ in their approaches to recruiting patients for global programs� Sponsors are more likely to engage one recruitment vendor for the entire program than CROs (64% vs 47%)� More than half of the respondents from CROs report they engage multiple firms in some form to recruit for global programs�

“For a global program, do you most often…?”

Recruiting patients for global programs

BEST PRACTICES IN PATIENT RECRUITMENT

22

Recruiting patients for global programs Sponsors and CROs differ in their approaches to recruiting patients for global programs. Sponsors are more likely to engage one recruitment vendor for the entire program than CROs (64% vs 47%). More than half of the respondents from CROs report they engage multiple firms in some form to recruit for global programs. “For a global program, do you most often…?”

16%

26%

11%

47%

3%

10%

22%

64%

0% 20% 40% 60% 80%

Mix methods/Case by case decision

Select one company for each country or region included in the study

Select one company for the home country and another for all other countries

Use one recruitment vendor for the entire program

% of Respondents

Sponsors (n=58) CROs (n=19)

© Industry Standard Research

S A M P L E P A G E :

RECRUITING PATIENTS FOR GLOBAL PROGRAMSThis page shows how sponsors and CROs differ in their approaches to patient recruitment for global programs.

The full data is available in the report, which can be downloaded from www.ISRreports.com.

D A T A I N F U L L R E P O R T


Introduction


Introduction

SPECIALIZED PATIENT RECRUITMENT FIRMS MARKET OVERVIEW


Utilization strategiesSponsors use specialized recruitment firms for a variety of reasons, with no single strategy standing out as a primary motivation for engaging a specialized recruitment firm� Among CROs, use of specialized recruitment firms to accelerate timelines (27%) stands out as the most popular strategy for engaging a specialized recruitment firm�

“On what percent of your studies do you utilize a specialized recruitment vendor for the following strategies?”


28

Utilization strategies Sponsors use specialized recruitment firms for a variety of reasons, with no single strategy standing out as a primary motivation for engaging a specialized recruitment firm. Among CROs, use of specialized recruitment firms to accelerate timelines (27%) stands out as the most popular strategy for engaging a specialized recruitment firm. “On what percent of your studies do you utilize a specialized recruitment vendor for the following strategies?”

18%

6%

15%

27%

11%

11%

11%

12%

12%

14%

14%

15%

0% 10% 20% 30%

High efficiency (reduce the number of sites to achieve the same # of patients)

Unknown therapeutic area (when a study is in a TA you have little experience in)

Risk Mitigation (using your same number of sites, use the recruitment company's "reserve of patients" as a

buffer in the event of a site enrollment fall off)

Acceleration (in a highly competitive scenario where you need to shorten enrollment timelines with the

same number of sites)

Rescue (bring in a vendor mid-trial when you anticipate or are experiencing lower-than-anticipated

site enrollment rates and delays)

Speed from the onset (use additional resources to increase recruitment from the start of the study)

% of Studies




UTILIZATION STRATEGIESAmong CROs, use of specialized recruitment firms to accelerate timelines (27%) stands out as the most popular strategy for engaging a specialized recruitment firm.

C L O S E R L O O K

<< CROs were least likely to cite an unkown therapeutic area as the reason to engage with a specialized recruitment vendor.

Data available in the full report, which can be found at:

www.ISRreports.com

Introduction

SPECIALIZED PATIENT RECRUITMENT FIRMS MARKET OVERVIEW


Utilization strategiesSponsors use specialized recruitment firms for a variety of reasons, with no single strategy standing out as a primary motivation for engaging a specialized recruitment firm� Among CROs, use of specialized recruitment firms to accelerate timelines (27%) stands out as the most popular strategy for engaging a specialized recruitment firm�

“On what percent of your studies do you utilize a specialized recruitment vendor for the following strategies?”


28

Utilization strategies Sponsors use specialized recruitment firms for a variety of reasons, with no single strategy standing out as a primary motivation for engaging a specialized recruitment firm. Among CROs, use of specialized recruitment firms to accelerate timelines (27%) stands out as the most popular strategy for engaging a specialized recruitment firm. “On what percent of your studies do you utilize a specialized recruitment vendor for the following strategies?”

18%

6%

15%

27%

11%

11%

11%

12%

12%

14%

14%

15%

0% 10% 20% 30%

High efficiency (reduce the number of sites to achieve the same # of patients)

Unknown therapeutic area (when a study is in a TA you have little experience in)

Risk Mitigation (using your same number of sites, use the recruitment company's "reserve of patients" as a

buffer in the event of a site enrollment fall off)

Acceleration (in a highly competitive scenario where you need to shorten enrollment timelines with the

same number of sites)

Rescue (bring in a vendor mid-trial when you anticipate or are experiencing lower-than-anticipated

site enrollment rates and delays)

Speed from the onset (use additional resources to increase recruitment from the start of the study)

% of Studies



D A T A I N F U L L R E P O R T


Introduction


Introduction

CRO PERFORMANCE RATINGS ON PATIENT RECRUITMENT


Capabilities — sponsors

Ratings Key: Clear leadership Better than most About average Falling a bit short Likely deficiency

Ability toprovide

transparency of recruitment

performance throughout the

process

Ability to support patient

retention throughout

the trial

Number of patients

who pass the

screening criteria

Quality of referred

patients that pass the

screening criteria

Accenture (n=16)

BioClinica (n=14)

Chiltern (including Theorem) (n=13)

Clinical Research Services (CRS) (n=14)

Cognizant (n=15)

Covance (n=28)

DCRI-Duke (n=11)

Eurofins (n=10)

ICON (n=29)

INC Research (n=14)

inVentiv Health Clinical (n=18)

PAREXEL (n=33)

PPD (n=28)

PRA (n=20)

Quintiles (n=37)

Worldwide Clinical Trials (n=15)

Ratings Key: Clear leadership Better than most About average Falling a bit short Likely deficiency

Cost per patient

randomized into the trial

Academic Network (a Stericycle company) (n=10)

Acurian (n=14)

Clinical Site Services (n=11)

Patient Recruiters International (n=10)

Praxis Communications (n=11)

The Patient Recruiting Agency (n=13)

DaVita Clinical Research

Eurofins

ICON

INC Research

inVentiv Health Clinical

Lambda

Medpace

Novotech

PAREXEL

PPD

PRA

QPS

Quintiles

Quotient Clinical

Rho

SGS Life Sciences

SynteractHCR

Theorem

US Oncology

Vince & Associates

WCCT Global

Worldwide Clinical Trials


CRO PATIENT RECRUITMENT SCORECARDSThis page shows how 16 CROs were rated by sponsors on their patient recruitment capabilities, enabling readers to quickly identify leaders in the industry.

The full data is available in the report, which can be downloaded from www.ISRreports.com.

Company #1

Company #2

Company #3

Company #4

Company #5

Company #6

Company #7

Company #8

Company #9

Company #10

Company #11

Company #12

Company #13

Company #14

Company #15

Company #16


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One size fits all; usually publically available data

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ISR’S REPORTS

THECOMMON

SYNDICATEDREPORT

VS.

RESEARCH METHODS

ISR’s proprietary data tools and channelssupport fast, high quality data collection

Struggle to recruit the right targets and enough of them

DATA COLLECTION

Sophisticated screening ensures genuine decision-makers make up respondents

Undisclosed methodologies and respondent demographics

RESPONDENTS

Robust sample sizes that instill confidence

Often insucient industry representationthat leaves you defending results

SAMPLE SIZE

Decades of experience means more insights that are immediately usable

Junior analysts capable of reporting numbers

ANALYSTS

ISR’S HEALTH PANELThe industry’s fastest growing panel of health care and pharmaceutical

professionals, with nearly 1,500 members worldwide.

BYJOB

LEVEL

Director 46%

Manager 29%

C-level 13%

VP 10%

BYEXPERIENCE

IN YEARS

16-20 years 23%

11-15 years 24%

6-10 years 11%

3-5 years 5%

20+ years 37%

BYCOMPANY

TYPE

Other 6%

Sponsor 78%

CRO 6%

ResearchSite 10%

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PREVIEW OF BEST PRACTICES IN PATIENT · PDF fileIntroduction Introduction FACILITATORS &...

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