Presynaptic Axon Terminal Postsynaptic Membrane Terminal Button Dendritic Spine.
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Transcript of Presynaptic Axon Terminal Postsynaptic Membrane Terminal Button Dendritic Spine.
![Page 1: Presynaptic Axon Terminal Postsynaptic Membrane Terminal Button Dendritic Spine.](https://reader036.fdocuments.in/reader036/viewer/2022081419/5697bfde1a28abf838cb2105/html5/thumbnails/1.jpg)
![Page 2: Presynaptic Axon Terminal Postsynaptic Membrane Terminal Button Dendritic Spine.](https://reader036.fdocuments.in/reader036/viewer/2022081419/5697bfde1a28abf838cb2105/html5/thumbnails/2.jpg)
PresynapticAxon Terminal
PostsynapticMembrane
Terminal Button Dendritic
Spine
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(1) Precursor Transport
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_ _ _
NT
(2) Synthesis
enzymes/cofactors
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(3) Storage
in vesicles
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Synapse
Vesicles
NT
Terminal Button
Dendritic Spine
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Synapse
Terminal Button
Dendritic Spine
(4) Release
Receptors
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Synapse
Terminal Button
Dendritic Spine
AP
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Ca2+
Exocytosis
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(5) Activation
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Quantum releaseEach vesicle contains one quanta of
neurotransmitter (approximately 5000 molecules) – quanta release
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(3) Transmitter Inactivation
1. Reuptake by presynaptic terminal2. Uptake by glial cells3. Enzymatic degradation4. Presynaptic receptor5. Diffusion6. Combination of above
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(6) Termination
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(1) Termination by... Diffusion
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(2) Termination by...Enzymatic degradation
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(3) Termination by...• Reuptake by presynaptic terminal• Uptake by glial cells
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(4) Termination by... Autoreceptors
A
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2. Receptor ActivationNS uses 40 families , act on 100 types of receptors; cause EPSPs and IPSPs,
Neuromodulators cause, via 2nd messengers, more complex metabolic effects in the PSM.
Ionotropic channel– directly controls channel– fast
• Metabotropic channel– second messenger systems– receptor indirectly controls channel ~
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(1) Ionotropic ChannelsneurotransmitterNTChannel
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Ionotropic Channels
NT
Pore
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Ionotropic Channels
NT
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Ionotropic Channels
NT
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G protein: Protein Phosphorylation
Receptor
trans-ducer
primaryeffector
external signal: nt
2d messenger
secondary effector
Receptor
trans-ducer
primaryeffector
external signal: NT
2d messenger
secondary effector
GS
norepinephrine
cAMP
protein kinase
b adrenergic -R
adenylylcyclase
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G protein: Protein Phosphorylation
RG
GDP
AC
PK
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G protein: Protein Phosphorylation
R
AC
PK
G
GTP
ATP
cAMP
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G protein: Protein Phosphorylation
R
AC
PK
G
GTP
ATP
cAMP
P
Pore
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