Presidential Illness
description
Transcript of Presidential Illness
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Presidential Illness
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William Henry Harrison
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Zachary Taylor
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Grover Cleveland
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Woodrow Wilson
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Franklin Delano Roosevelt
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George H.W. and George W. Bush
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King George III (6/4/1738-1/29/1820)
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The Madness of King George III
• First signs of dementia in 1788-1789
• Institutionalized at Windsor Castle from 1811-1820
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Porphyria
• Caused by a dominant allele that alters the shape of the porphyrin ring in hemoglobin
• Symptoms include insanity, extreme photosensitivity, itchy skin and dark urine
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How Do We Know King George Had Porphyria
(and not Arsenic Poisoning?)
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Why Are Royal Families Useful For Genetic Research?
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Mdekwanton
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Mdekwanton Geneology
• All members of the Mdekwanton tribe (Lakota Sioux Nation) receive tax free income due to their ancestry
• Must prove you are at least 25% Mdekwanton by blood
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Pedigree Analyses
• Diagrams that demonstrate possible modes of inheritance for various traits through careful organization of demographic and phenotypic data
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(i.e. person in question)
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How Can Pedigree Diagrams Be Used To Determine The Mode of Inheritance
For A Given Trait?
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Four Modes of Inheritance
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Autosomal Dominant
• 75% of traits are governed by autosomal dominant inheritance
• As long as one dominant allele is received, the phenotype will be dominant
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Pedigree Characteristics of Autosomal Dominant Inheritance• Trait is found in all
generations
• Equal sex-distribution among males and females
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Example: Huntington’s Chorea
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Huntington’s Chorea Effects
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Autosomal Recessive
• Both copies of the recessive allele must be received to express the recessive phenotype
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Tay Sachs Disease
• Recessive allele causes buildup of a fatty material called GM2 to build up around nerve cells, inhibiting their function
• Fatal by age 5• No cure• First noted by red spot
in back of retina
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Tay Sachs Inheritance
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Non-Autosomal/Sex-Linked Dominant Inheritance
• Traits must be carried on either the X or Y chromosome
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Pedigree Characteristics of Sex-Linked Dominant Inheritance• Present In Every
Generation• Less frequent in
males due to pleiotropy
• Affected fathers must have affected daughters (if x-linked)
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Non-Autosomal/Sex-Linked Recessive Inheritance
• Trait is located on X or Y chromosome
• Trait may be masked by dominant allele if X chromosomes appear as homologous pair (i.e. female)
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Pedigree Characteristics of Sex-Linked Recessive Inheritance
• Skipping of generations
• One sex unequally represented in phenotypic outcomes
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Hemophilia & The Royal Houses of Europe
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