INDENA’S HISTORY1921 - Foundation of the joint stockcompany Dott. Inverni & della Beffa S.p.A.by Carlo Boccaccio Inverni and Biagio Alberto Della Beffa

1969 - Set up of a pivotal developmentcentre in Settala (near Milan)

Early 1980 - Reorganisation of the botanical derivatives business underIndena S.p.A.

1990 - Creation of the parent companyIdB Holding S.p.A. and opening of commercial branches and new production plants worldwide

OUR MISSION

At Indena we believe that an in-depthknowledge in active ingredientsderived from medicinal plants andthe search for excellence at all timesare crucial commitments to servingour customers in pharmaceuticals,health foods and cosmetics.

Research and production technologiesare the main focus of our missionand the way we create a“value difference” for our partners.And we’ve got more than 80 years ofexperience to prove it.

A RESEARCH BASED COMPANYThere are two main sectors of Indena research:

Product research: Identification of new active principlesderived from plants for pharmaceuticals, health foods and cosmetics

Process research: Original advanced industrial production processes are designed and engineered for work on existing or new molecules

ADVANCED RESEARCH FROM SOUND TRADITIONOur product research is carried out setting-up innovative botanicalderivatives through:

Ethnopharmacology fromindustrialised and emergingcountries

High throughput and targetedscreening

New uses of traditional and alreadydeveloped botanical products

Pre-clinical and clinical (Phase I/II)development

FACTS & FIGURES

more than 700 employees

4 international branches

5 production sites in the world

sales in over 40 countries

more than 150 primary patents

THE INDENA MARKETIndena pursues

excellence with the

goal of being

recognised within the

botanical derivatives

field as the partner of choice for the best

companies offering

their customers

innovative products.

MAIN PRODUCT CATEGORIESISOLATED PURE PRODUCTSPure molecules isolated frommedicinal plants

SELECTED ACTIVE PRINCIPLESWhole of natural substances belongingto the same chemical class

STANDARDISED EXTRACTSTotal extracts with a reproduciblecontent of active or characteristicprinciples

FORMULATED PREMIXESBulk formulations of active principlesready for use

PHYTOSOME®

Complexes of active principles and phospholipids

Isolated pure products are at the cutting edgeof our research and technological know-how.

Isolated pure products are single highlypurified molecules isolated from medicinalplants such as:

PACLITAXEL Anti-cancer

10-DAB III Intermediate foranti-cancers

THIOCOLCHICOSIDE Muscle relaxant

COLCHICINE Antigout

TYPICAL PHARMACEUTICAL PRODUCTS

Standardised extracts were introduced inthe health food market by Indena more than 20 years ago.

Some of our most importantstandardised extracts:

MIRTOSELECT® (Bilberry)GINSELECT® (Ginseng)LEUCOSELECT® (Grape Seed)GREENSELECT® (Green Tea)SABALSELECT® (Saw Palmetto)SOYSELECT® (Soybean)

Indena standardised extracts have full chemical characterization backed up by QUALITY, SAFETY AND EFFICACY TESTS.

TYPICAL HEALTH FOOD PRODUCTS

Indena leverages its solid pharmaceutical background for the cosmetic field, developing functional ingredients with a wide range of applications for “high”skin & hair care products, such as:

ESCIN FREE ACIDCENTELLA ASIATICA TRITERPENESRUSCOGENINSCURBILENE®

ZANTHALENE®

PHYTOSOME®, a complex of activeprinciples and purified soybeanphospholipids

TYPICAL SKIN & HAIR CAREPRODUCTS

BOTANICAL SOURCESIndena sources officinal plants througha worldwide network of plantations:

Control of more than 6,000 acresof GAP (Good Agricultural Practice)compliant plantations

More than 60% of the botanical rawmaterial is grown in plantations

On certain product lines we conductplant breeding operations withmaximum respect of environmentand biodiversity

INDENAPRODUCTIONWe guarantee:

High containment GMP (Good Manufacturing Practices)grade facilities fully dedicatedto the production of cytotoxic compounds

Controlled area for final purificationsteps, HEPA filtered, fully validatedDrying, finishing and packaging operations using glove boxes units

Compliance with GMP

Scale-up of new active principles, including those patented and licensed by customers

Huge extraction capacity over 20,000 metric tons of botanicals per year

Health food pre-mixed preparation

THE BIOTECHNOLOGY CHALLENGEIndena resources are dedicated to research and development in the following fields:microbial fermentation and biotransformationenzyme conversionplant cell and tissue culture (fermentation and micropropagation)protein technologyrecombinant DNAIndena production expertise is focused on:plant and microbial secondary metabolitesplant proteins and peptidesThis has led to the development of:active pharmaceutical ingredientsactive principles for genericsfunctional ingredients for nutraceuticalsand cosmeceuticals

INDENA QUALITY SYSTEMThe Indena Quality System is based on:

QUALITY ASSURANCE QUALITY CONTROL

The Indena Quality System ensures that allmanufacturing, control and packaging processes comply with current GMP.

HACCP (Hazard Analysis Critical Control Points) is performed if needed.

Indena is routinely inspected by FDA, and by the Italian Ministry of Health Agency (AIFA) for GMP compliance assessment.

Customers such as internationalpharmaceutical companies may also conducttheir own audits.

YOUR PARTNEROF CHOICEWe share with our partners:

Our expertise in agronomy, phytochemistry, and ethnopharmacology

Our GAP compliant plantationsnetwork

Our production capabilities at lab,pilot and industrial scale

Our know-how in the formulationof botanical ingredients

CUSTOMER ADVISORY SERVICEWe constantly stand by our customers’ side with:

Scientific support (original phytochemical/biologicaldocumentation and innovation support)

Technical support

Formulation support (advise and laboratory sample preparation of solid and liquid forms)

Indena’s experts constantly communicateand interact with the major international

REGULATORY AUTHORITIES:EMEA - European Agency for the Evaluation

of Medicinal ProductsEPh - European Pharmacopoeias

ESCOP - European Scientific Cooperative on Phytotherapy

FU - Italian PharmacopoeiaNCCAM - National Centre for

Complementaryand Alternative Medicine

NIH - National Institutes of HealthWHO - World Health Organisation

USP - US Pharmacopoeia

Indena is an active memberof all the relevantSECTOR ASSOCIATIONS:ABC – American Botanical CouncilAHPA – American Herbal Products AssociationAssoerbeAESGP – Association Européenne des Spécialités Pharmaceutiques Grand PublicCRN – Council for Responsible NutritionCRN Japan – Council for Responsible Nutrition of JapanFederchimica (Additivi Alimentari, Aschimfarma, Assobiotec, MAPIC)Japan Health Food & Nutrition Food AssociationJFAA – Japan Food Additives AssociationKooperation Phytopharmaka – GermanyNNFA Japan – National Nutritional Foods Association JapanSIFIT – Società Italiana di FitoterapiaSYNADIET – Syndicat National des Fabricants en Produits Diététiques, Naturels et Compléments AlimentairesUNPA – Utah Natural Products Association

INDENA: A PROACTIVE VOICE

COMMUNICATING OUR SCIENCEWe communicate our scientific knowledgethrough:

Partnership with Universities to createand support post-graduate educationin phytotherapy

Participation in major scientificevents and trade exhibitions

Co-marketing activities withcustomers

Regular contributions to scientific, corporate and trade publications

Fitoterapia, a journal founded in 1924 and today recognised worldwide as a premier source for the latest researchon medicinal plants,now distributedby Elsevier

INTERNATIONAL BRANCHESIndena France S.A.S. - Paris, France Indena USA Inc. - Seattle, WA, USA Indena Japan Co. Ltd. - Tokyo, JapanIndena Biotechnology (Shanghai) Co., Ltd.Shanghai, China

THE INDENA ORGANISATION

HEADQUARTERS Indena S.p.A. - Milan, Italy

Indena S.p.A. - Milan, ItalyIndena S.p.A. - Settala (MI), ItalyBernett S.r.l.- Palestro (PV), ItalyIndena S.A.S. - Tours, France Indena India Pvt. Ltd. - Bangalore, India

PRODUCTIONSITES