Presentazione di PowerPoint - Natali... · ABSTRACT Evolocumab is a monodmal antibody that inhibits...
Transcript of Presentazione di PowerPoint - Natali... · ABSTRACT Evolocumab is a monodmal antibody that inhibits...
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-15%
-20%
-27%
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Effect on all lipid parameter
BP? BMI? HbA1c?
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∂ -83 mg/dl = 17%
∂-51 mg/dl = -22%
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Arrampicarsi sulgli specchi
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Verificare ?
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switch
Dosing diff
?
hsCRP
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Patients disposal
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Real efficacy
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Sottogruppi
!!!
!!!
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Sporco trucco ?
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20
30
40
6 9 12
Years “lost” per 100 pts in 12 years
30*12/2= 18040*12/2= 240
240-180= 6060/30= 2.0
400E*100pts*12m*12y = 5.760M 5.760M/60= 96.000 E/y
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?
Ha atteso le aspettative?
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38/22 = 0.57 %/mg 60/20 = 0.33 %/mg
0.33/0.57 = 0.57
a: (GISSI Prevenzione) b: (ALLHAT-LLT);c: (ALERT) d: (LIPS)e: (AFCAPS/TexCAPS) f: (CARE)g: (LIPID) H: (PROSPER) i: (ASCOT-LLA) J: (WOSCOPS)k: (Post CABG) L: (CARDS)38m: (HPS) n:(4S)
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Lettura critica di un articolo scientifico
1) Chi lo ha scritto?2) Abstract Razionale
ConclusioniMetodiRisultati
3) Caratteristiche della Popolazione4) Effetto dell’intervento sui parametri rilevanti 4) Effetto dell’intervento sugli outcomes5) Discussione6) Appendice