Study of the behavior of an oncolytic virus as a therapy for cancer

Nicole S. Rivera EspinalRISE bridge summer

program 2014

Introduction Cancer is one of the leading causes of dead not only in the USA but around the world.

http://upload.wikimedia.org/wikipedia/en/6/6e/Generalised_diagram_of_the_cancer_specificty_of_oncolytic_viruses.png

Oncolytic Viruses

http://upload.wikimedia.org/wikipedia/en/6/6e/Generalised_diagram_of_the_cancer_specificty_of_oncolytic_viruses.png

Oncolytic Viruses

http://upload.wikimedia.org/wikipedia/en/6/6e/Generalised_diagram_of_the_cancer_specificty_of_oncolytic_viruses.png

Wosnick, M. (2012, March 14). Oncolytic virus | Mediander | Connects. Mediander. Retrieved June 30, 2014, from http://www.mediander.com/connects/1723667/oncolytic-virus/#!/

Previous research with Oncolytic virus

http://youtu.be/lTukSQpiDXM

http://youtu.be/lTukSQpiDXM

Lung cancer cell in ratsOncolytic virus

Normal rat lungs Rat lungs with cancer tumors and nodules

Wosnick, M. (2012, March 14). Oncolytic virus | Mediander | Connects. Mediander. Retrieved June 30, 2014, from http://www.mediander.com/connects/1723667/oncolytic-virus/#!/

http://youtu.be/lTukSQpiDXM http://youtu.be/lTukSQpiDXM

Wosnick, M. (2012, March 14). Oncolytic virus | Mediander | Connects. Mediander. Retrieved June 30, 2014, from http://www.mediander.com/connects/

1723667/oncolytic-virus/#!/

http://youtu.be/lTukSQpiDXMhttp://youtu.be/lTukSQpiDXM

Green biochemical track

Hypothesis

The oncolytic virus will recognize a genetic trigger

that will not be found in the normal cell

Research design

First objective: observe and determine what are the genetic triggers that causes the viruses to infect the cancer cell.

Long time goal : investigate how many cancer types can be treated with this type of viruses.

Methodology

http://upload.wikimedia.org/wikipedia/en/6/6e/Generalised_diagram_of_the_cancer_specificty_of_oncolytic_viruses.png

Objectives : investigate the genetic differences between a cancer cells and a healthy ones.

Methodology Objectives : investigate the genetic differences between a

cancer cells and a healthy ones.

• DNA microrray (In both cell)

• Genetic marker

Reece, J., Urry, L., Coin, M., Wasseman, S., Minosky, P., & Jackson, R. (2013). DNA Tools and Biotechnology . Campbell Biology 10th edition (). : Pearson. (Original work

published )

Reference

Adair, R., Roulstone, V., Rouse, A., & Melcher, A. (2012)4(138) pag 137. Cell Carriage, Delivery, and Selective Replication of an Oncolytic Virus in Tumor in Patients. . Retrieved June 17, 2014, from http://stm.sciencemag.org/content/4/138/138ra77.abstract

Zamarin, D., Holmgaard, R., & Mansour, M. (2013). CANCER IMMUNOTHERAPY. . Retrieved June 16, 2014, from http://stm.sciencemag.org/content/6/226/226ra32.abstract

Kim, M. K., Kirn, D., & Moon, A. (2013). Oncolytic and Immunotherapeutic Vaccinia Induces Antibody-Mediated Complement-Dependent Cancer Cell Lysis in Humans. . Retrieved June 13, 2014, from http://stm.sciencemag.org/content/5/185/185ra63.abstract

Wosnick, M. (2012, March 14). Oncolytic virus | Mediander | Connects. Mediander. Retrieved June 30, 2014, from http://www.mediander.com/connects/1723667/oncolytic-virus/#!/

Reece, J., Urry, L., Coin, M., Wasseman, S., Minosky, P., & Jackson, R. (2013). DNA Tools and Biotechnology . Campbell Biology 10th edition (). : Pearson. (Original work published )