Presentación de PowerPoint - BioBarica · Fibromyalgia Rheumatoid ... PRESENTATION OF CASES...
Transcript of Presentación de PowerPoint - BioBarica · Fibromyalgia Rheumatoid ... PRESENTATION OF CASES...
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BIOBARICAGLOBAL NETWORK OFHYPERBARIC THERAPY
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1. BIOBARICA INTRODUCTION2. MEDICAL PRESENTATION3. TECHNICAL PRESENTATION
BIOBARICA SYSTEM
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WHO WE ARE
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BIOBARICA IN THE WORLD We are in more than 28 countries of the world.
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BIOBARICA SYSTEM
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ADRESSED TO
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WHERE WE WORK
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BIOBARICA PROVEN THERAPEUTIC EFFICIENCY
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WHY IS THIS HYPERBARIC CHAMBER UNIQUE?
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BIOBARICA GLOBAL SYSTEM
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BIOBARICA
CLINICAL RESEARCH
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BioBarica provides all the communication segmented by audiences: operators, doctors and patients needed to reach all those who are related to the hyperbaric treatment.
We work to develop messages based on concepts tested by market research.
We promote the hyperbaric medicine that is constantly growing. New applications are constantly discovered.
BIOBARICACOMUNICATION
Our communication is based on transmitting our know how to the medical community and patients through the correct pieces of information and providing training.
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GLOBAL OUTREACH
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CONTRACT LIABILITY
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BUSINESS ALTERNATIVES
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Step 1 (1 day)
•Sign Confidentiality Agreement
•BioBarica providescomercial and medical documentation
Step 2 (3 days)
•Discuss ket termsof the contract
•Sign contractwith BioBarica
Step 3 (7 days)
•Purchasehyperbaricchamber (DEMO)
•BioBarica deliversthe chamber
Step 4 (2 days)
•Installation and training byBioBarica
•The hyperbaricmedicine unit isready to operate.
Certification(time dependson the country)
Developmentand growing
DISTRIBUTORS PROCESS AND TIMING
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BIOBARICA IN NUMBERS
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1. BIOBARICA INTRODUCTION2. MEDICAL PRESENTATION3. TECHNICAL PRESENTATION
HYPERBARIC MEDICINE
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Increasing the concentration of O2 that we breathe
Increasing the pressure of the air we breathe (environment ≥1.45 ATM) *
O2 100% HYPERBARIA
O2 dissolved in blood: HYPEROXIA reaching very poorly
irrigated tissues and producing other physiological effects
TREATMENT
HYPERBARIC OXYGENATION (HBOT)
*Undersea and Hyperbaric Medicine Society >>>1.4 ATA
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DALTON'S LAW
The pressure of a mixture of
gases is equal to the sum of
partial pressures (Pp) of each of
the gases that compose it.
HENRY'S LAW
Gases dissolve in liquids
when under pressure.
PHYSIOLOGY OF OXYGENPHYSICOCHEMICAL FUNDAMENTALS
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PHYSIOLOGY OF OXYGENAnalogy with a Sparkling Wather bottle
You can see no bubbles in a closed sparklingwater bottle. When you open it, bubblesappear. This is due to the physical laws statingthat gasses dilute in liquid when they are underpressure.
The same physical laws apply to our body.When O2 is breathed in a pressurized cabin, theO2 dilutes in blood plasma, which is 50% water.
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PHYSIOLOGY OF OXYGEN
Normobaria (Air at sea level):
Atmospheric pressure: 760 mmHg (1 ATA)
Partial concentration of O2: 21%
Pp O2: 0.21 x 760 mmHg = 160 mmH
Hyperbaria: 1.45 ATA
Partial concentration of O2: 21%
Pp O2: 0.21 x (1.45 x760 mmHg) = 231 mmHg
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FiO2: (Fraction Inspired by O2 - VN: 0.21)
VH20: 47 mmHg (internal humidity - Water)
PACO2: 40 mmHg (Alveolar Pressure CO2)
CR = 0.8 (respiratory coefficient between CO2 and O2)
Alveolar pressure of the O2
PAO2 = (760 - 47) x 0.21 - 40 / 0.8 = 100 mmHg
100% O2 to 1.45 ATA: PAO2 = (760 * 1.45 - 47) x 1 - 40 / 0.8 = 950 mmHg
INCREASING
THE PRESSURE
IN THE
ALVEOLO
INCREASES THE
DISSEMINATION
TO THE PLASMA
VH20 PACO2 CR
PHYSIOLOGY OF OXYGEN
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CONTENT OF
O2 IN THE BLOOD
The hyperbaric effect on dissolved oxygen:
1. Normobaric air (21% O2 1 ATA 97% Hb): 0.3ml / dl dissolved oxygen2. Hyperbaric oxygen (100% 1.45 ATA 100% Hb): 3.0 ml / dl dissolved oxygen
Hyperoxia:
Increases 10 times the amount of dissolved oxygen (independent of Hemoglobin) O2 is immediately and completely available for cells.
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TREATMENT
HYPERBARIC OXYGENATIONEssential effect of Hyperbaric Oxygenation
Oxygenate the tissues
The average density of capillaries varies in tissues (~ 600 / mm3)• 2500-3000 / mm3 (brain, kidneys, liver, myocardium);• 300-400 / mm3 (skeletal muscles);• <100 / mm3 (bones, adipose tissue, connective tissue)
Average separation of ~ 40μm between adjacent capillaries
Distance capillary cells in living tissues: ~ 1-3 cells
Source: Robert A. Freitas Jr., Nanomedicine, Volume I: Basic Capabilities, Landes Bioscience, Georgetown, TX, 1999
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Describes radial gradients of PO2 in a tissue cylinder
of radius R. The model considers the O2 consumption,
the solubility, the diffusion coefficient of O2 and the
non-linear fall of PO2 from the arterial to the venous
end of the capillary.
It allows calculating the PO2 at any point r, where c is
the radius of the capillary and r is the distance from
the center of the capillary inside the tissue cylinder.
The penetration of O2 into tissues is a function of PO2
BLOOD END
VENOUS END
a.radial
L
L
DISSEMINATION OF O2:
KROGH MODEL
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DISSEMINATION OF O2:
KROGH MODELO2 Penetration to tissues:
Pressure in hyperbaric chamber = 1.45 ATA
generates PO2arterial = 950mmHg
Minimum effective PO2, tissue = 20mmHg
Penetration radius ~ 75μm (diameter ~ 150 μm)
Under these conditions, the penetration of O2 into
all tissue cells is guaranteed
950mmHg
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PHYSIOLOGICAL EFFECTS
O2 gradient between the alveolus and pulmonary capillary
O2 diffusion and availability in tissues
Blood pressure of O2 and amount of dissolved O2:
HYPEROXIA (independent of hemoglobin)
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AEROBIC METABOLISM
Through HBOT, O2 is administered as an active ingredient, seeking to maximize the oxygenation of
tissues to fulfill cellular and metabolic functions.
Molecular oxygen (O2) is an essential element for the cell: its main "mechanism of action" is to
participate as fuel in the energy supply of the cell.
O2
Energy production
ATP
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FREE RADICALSFree radicals (RL) are chemical species with
an unpaired electron in their outer orbit. The
RL seek to match that electron, so they are
highly reactive. Oxygen is also present in the
form of RL (EROs) used by our body for
multiple functions:
• Inflammatory and immunological
response (against viruses and / or
bacteria)
• Proliferation and cell division
• Apoptosis
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EROs
OXIDATIVE STRESSANTIOXIDANT DEFENSE
BALANCE OF THE OXIDIZING SYSTEM - ANTIOXIDANT
DISBALANCE: DISEASE
(H₂O₂ -0₂ -OH NO NOO-)
antioxidant
Free radical
electron
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MECHANISM OF ACTION - HOBT
HYPEROXIA
EROs production
Improves the antioxidant system
Objective: to guarantee the arrival of O2 to tissues to fulfill
biochemical, metabolic and physiological functions
InglésInglésInglés
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HYPERBARIC OXYGEN
GENERATES A STRONG HYPEROXIA
BENEFICIAL PHYSIOLOGICAL EFFECTS
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HYPEROXIA - PHYSIOLOGICAL EFFECTS
VASOCONSTRICTION
ANGIOGENESIS
OSTEOGÉNESIS
CELLULAR IMMUNITY
PERIPHERAL AXONAL
REGENERATION
COLLAGEN SYNTHESIS
OXIDATIVE STRESS AND INFLAMMATORY RESPONSE
NEURAL FUNCTION
PROLIFERATION AND STIMULATION
OF MOTHER CELLS
GRAFTS AND FLANGES
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OXYGEN DOSEThe therapeutic effect of hyperoxia is
determined by the dose of oxygen.
The dose of oxygen depends on 5 variables:
• % of O2
• Pressure of the camera
• Duration of the session
• Session frequency
• Total number of sessions
5 weekly sessions
4 weekly sessions
3 weekly sessions
2 weekly sessions
1 weekly session
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INDICATION OF THE TREATMENTSessions
Generally, a minimum of 10-20 sessions are indicated, according to the pathology of each patient.
Duration of the session
The average time used is 60 minutes. In acute patients, sessions of 90 minutes up to 2 times a day
are performed.
Session cycle
Number of sessions to be done indicating: total number, daily amount, weekly periodicity (1 to 6)
and duration of the session.
Intercycle period
Rest indicated between cycles.
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HBOT: INDICATIONS
MEDICAL CLINIC
• Fibromyalgia
• Chronic fatigue
• Migraines and headaches
• Tinnitus
• Geriatrics
• Apneas of sleep
• Crohn's disease
Adjuvant treatment that reduces inflammation and edema, relieves pain, improves tissue perfusion, energy efficiency and quality of life.
Inglés
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• Trauma
• Pre and post-surgical
• Progressive bacterial gangrene
• Acute traumatic ischemia
• Ligament injuries
• Osteomyelitis
Adjuvant treatment accelerates recovery and healing, reduces inflammation and edema, relieves pain, reduces the risk of infection and amputation and improves quality of life.
HBOT: INDICATIONS
TRAUMATOLOGY
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Adjuvant treatment prepares athletes during training, improves energy efficiency, shortens recovery, prevents fatigue and improves injury rehabilitation.
• Training
• Muscle and tendon injuries
• Post-exercise recovery
• Chronic Fatigue Syndrome
HBOT: INDICATIONS
SPORT MEDICINE
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• ACV
• Parkinson's disease
• Multiple sclerosis
• Alzheimer disease
Adjuvant treatment reduces edema, redistributes blood flow and improves cerebral oxygenation, reduces spasticity and tremors, improves cognitive function, neuroprotection and quality of life.
PEDIATRIC PATIENT:
• Autism
• TGD
• Cerebral palsy
• Detoxification
HBOT: INDICATIONS
NEUROLOGY
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• Wounds
• Ulcers - Diabetic foot
• Venous ulcers
• Post-surgical injuries
• Burns
• Grafts and implants
The treatment of hyperbaric oxygenation accelerates healing, favors angiogenesis, reduces
inflammation and edema, stimulates collagen synthesis, triggers the immune response and
improves perfusion.
HBOT: INDICATIONS
WOUNDS
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Fibromyalgia
Rheumatoid arthritis
Osteoarthritis
Bone edema
Bone necrosis
Osteomyelitis
Adjuvant treatment to accelerate recovery, relieve pain, reduce inflammation and edema, reduce the risk of infection and improve quality of life.
HBOT: INDICATIONS
REUMATOLOGY
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• Tumors
• Radio-necrosis and radiotherapy
Adjuvant treatment to improve sensitivity to radio and chemotherapy, control tumor growth, relieve
pain, prevent and recover radio-necrosis and improve quality of life
HBOT: INDICATIONS
ONCOLOGY
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EVIDENCE ANDPRESENTATION OF CASES
VARIOUS ESSAYS, SERIES AND CASE REPORTS
RAISE THE EFFECTIVENESS OF HBOT AS A
SUCCESSFUL TREATMENT FOR DIFFERENT
DISEASES.
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Hyperbaric Oxygen Induces Late Neuroplasticity
in Post Stroke Patients - Randomized,
Prospective Trial
Shai Efrati1,2,3*, Gregori Fishlev1, Yair Bechor1,
Olga Volkov3,4, Jacob Bergan1, Kostantin
Kliakhandler5,
Izhak Kamiager3,6, Nachum Gal1, Mony
Friedman1, Eshel Ben-Jacob2,5,7, Haim Golan3,4
Hyperbaric Oxygen Induces Late Neuroplasticity in PostStroke Patients -Randomized, Prospective Trial
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A normal and healthy adult brain
should be seen primarily yellow in
the SPECT scanner. Green
indicates lower blood flow and
oxygen. Blue and violet represent
a significant reduction of blood
flow in the brain.
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Patient: Man.
Age: 60 years.
Diagnosis: Ischemic ulcer - rheumatoid arthritis
Number of sessions: 40
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Patient: Man.
Age: 60 years.
Diagnosis: Ischemic ulcer - rheumatoid arthritis
Number of sessions: 40
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Patient: Man.
Age: 27 years.
Diagnosis: Arteriovenous fistula
Number of sessions: 34
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Patient: Man.
Age: 27 years.
Diagnosis: Arteriovenous fistula
Number of sessions: 34
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Patient: Man.
Age: 60 years.
Diagnosis: Post-heart surgery
Number of sessions: 35
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Patient: Man.
Age: 60 years.
Diagnosis: lower limb, Necrosis, circulatory failure.
Number of sessions: 20
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Patient: Male.
Age: 5 years
Diagnosis: Arteriovenous malformation
Number of sessions: 70
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Patient: Man
Age: 70 years.
Diagnosis: Diabetic ulcer
Number of sessions: 70
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Patient: Woman
Age: 90 years.
Diagnosis: Gluteal scapula
Number of sessions: 35
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Patient: Woman
Age: 60 years.
Diagnosis: Pyoderma gangrenosum
Number of sessions: 40
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Patient: Woman
Age: 11 years
Diagnosis: Trauma
Number of sessions: 40
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Patient: Woman
Age: 70 years.
Diagnosis: Lip melanoma
Number of sessions: 20
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Patient: Man.
Age: 90 years.
Diagnosis: Venous insufficiency
Number of sessions: 20
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Patient: Man.
Age: 90 years.
Diagnosis: Venous insufficiency
Number of sessions: 20
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Patient: Baby.
Age: 3 days.
Diagnosis: Penicillin reaction
Number of sessions: 3
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Patient: Baby.
Age: 3 Weks.
Diagnosis: Fasciitis Necrotizing.
Number of sessions: 10
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AbsolutePneumothorax not treatedBulla Pulmonar
RelativeTympanic perforationCancer treatment (Bleomycin, Cisplatin, Doxorubicin, Disulfiram)Pacemaker
Special caresMild hypoglycemic and Hypertensive.Congestion or catarrhClaustrophobiaPathology of VAS and COPD
CONTRAINDICATIONS
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HYPERBARIC TREATMENT WITHREVITALAIR 430 CHAMBERS
Verification protocol in healthy patients:
It concludes:
Treatment at 1.45 ATA does not modify the biochemical parameters of acute phase
inflammation and oxidative stress in healthy volunteers.
Significant increase in antioxidant enzyme suggests the effect of hyperoxia in healthy
The biochemical parameters at 10 and 20 sessions are kept within the values of reference.
The treatment is safe and well tolerated, without adverse effects
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CONCLUSION
The strong HYPEROXIA increases the volume of dissolvedoxygen in the blood plasma. This increase in O2 diffusionreaches less irrigated tissues.
Hyperoxia produces a broad chain of PHYSIOLOGICAL BENEFITS in the body.
HYPERBARIC TREATMENT: The patient breathes high doses of O2 in a hyperbaric environment.
SYSTEMIC PERFORMANCE IN PATHOLOGIES.
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1. BIOBARICA INTRODUCTION2. MEDICAL PRESENTATION3. TECHNICAL PRESENTATION
INSTALLATION AND OPERATION OF THE HYPERBARIC CHAMBER
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Hermetic Cabin: It is pressurized in a stable manner (Treatment Pressure), where the patient remains during the session.
Compressors Cabinet: It enters filtered air into the cabin to reach the treatment pressure by venting in a safe manner.
Oxygen external source:It may be by hub or tank, it supplies high-concentration of O2 to the patient.
COMPONENTS
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HYPERBARIC CHAMBER
COMPONENTS
➔ Components:Cabin pressurizationCompressor cabinetSupport tableBioBarica Support systems
➔ Optional:
Removable Stretcher for patients with low mobility.
O2 Concentrator.
Monitoring System via Web
Extended warranty.
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Please read the User Manual carefully. It will tell you step by stephow to operate and maintain this high-technology medical product.
HYPERBARIC CHAMBER
INSTALLMENT
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HYPERBARIC CHAMBER
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BioBarica recommends 3 brands:
Airsep, Intensity 10 model - High Flow 10 liters per minute.
NidekMedical - Novo 10 - High Flow 10 liters per minute.
Hikoneb® OxyBreath 10L - High Flow 10 liters per minute.
OXYGEN CONCENTRATOR
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Oxygen mask with reservoir bag isrecommended for maximumtherapeutic efficiency.
➢ We recommend using the mask closed
and exhaust valves clogged.
➢ This mask delivers 100% O2 available.
➢ The more O2 inspire the most effective
treatment will be patient.
➢ Some children do not like to use the
mask and you have to place them
mustache but this reduces to 50% O2
concentration.
OXYGEN MASKS
If the mask for local use matches the characteristics sent to the equipment or is similar, you can validate it use with BioBarica.
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Hyperbaric Chamber MaintenanceThe maintenance is performed by the equipment operator with the instructions mentioned in theBioBarica Global System. The online system alerts the operator of all the necessary maintenancefor the equipment to operate properly.
Technical SupportBioBarica offers an extended warranty of up to 4 years (optional), in which case any problemthat may arise can be solved with the replacement of the chamber with a new one which will be sent immediately.
WarrantyThe chamber includes a one year warranty, except the closure system of the chamber which a lifetime warranty. An optional, extended warranty of up to 4 years can be purchased.
TECHNICAL FEATURES
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What are the differences with the hard-shelled chambers?
Hard-shelled chambers use with high pressure levels that require high maintenance costs and
specialized operators. They also have more safety requirements and the treatment is much
more aggressive and stressful for the patient.
What advantages do these chambers have compare to lower pressure?
In the market there are low-pressure chambers that operate on 1.3 ATM, which are offered at a
lower price range. The Revitalair 430 is a certified medical device that operates at 1.4 ATM,
which is the minimum pressure necessary for hyperbaric treatment.
Chamber Operation
The device can operate all day. Brief resting periods of only five minutes per hour is sufficient,
and it is the same time between patients.
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Rev
ital
air
43
0 • 1.4 ATA*
• 120Kg
• 95% of pathologies
Hig
h p
ress
ure • 3 ATA
• +1000 kg
• 100% of pathologies
Low
pre
ssu
re • 1.3ATA
• 45-60Kg
• - 30% of pathologies
*According to the UHMS of the United States the definition of hyperbaric treatment is from 1.4 ATA
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Installation: Revitalair 430® cameras are assembled in little time and do not require much space. The minimum measures are 1,70m x 2,80m.
Maintenance: These cameras are easy to maintain and clean by the user.
Portable: simple to assemble in any place.
High-pressure chambers need special space, of greater size and complexity.
They also require regular hydraulic testing for maintenance and specialized technicians.
These high pressure chambers weigh approximately 1000kg and are dangerous to operate.
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Revitalair 430High pressure
chamber The Revitalair 430 hyperbaric chambers are
easy to opérate by the user withoutassistance.
Security: It has increased air flowof air and 4 security valves.
In these chambers, patients enter with any type of clothing.
También se puede ingresar con libros y electrónica (celular, Tablet, etc.).
High pressure hyperbaric chambers require a specialized technician to operate.
Due to their operation in high pressure, they require greater safety measures.
Patients must enter the chamber with cotton
clothing.
Entering with electronic devices is completely forbidden.
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Revitalair 430 Hyperbaric Chamber
Low pressurechamber
Patented door locking system (lifetime warranty).
Removable stretcher. Ease of entry for people with reduced mobility.
Children can enter the chamber
accompanied by an adult.
Zipper system, less durability and does not achieve complete sealing.
These chambers are located on the ground, making it difficult for people with reduced mobility to enter. They does not have a stretcher.
Due to space, only one person per session is allowed.
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BIOBARICA CENTER
Infrastructure
Air-conditioning & Signage
Procedures for attention & Cleaning
BioBarica Global System - Hipermed
OPERATIONAL GUIDELINE OF A BIOBARICA CENTER
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IMPORTANTHow many patients can be treated per month?
Consider:An patient needs 14 sessions average.
It provides service 10 hours a day in 22 days a month.Availability per month: 220 hours of treatment.
220 Hs. / 1 hour 14 sessions = 15.7 patients per month.
10 minutes time between sessions (plus scheduling problems ) = 20% of the time.
Patients that can be attend per month =
14 patients
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BIOBARICA GLOBAL SYSTEMHipermed
Tickets
Trainings
Blog
Maintenance
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BIOBARICA GIVES YOU A COMPLETE MEDICAL, TECHNICAL AND COMMERTIAL
TRAINNING SUPPORT
OUR HYPERBARIC CHAMBERS ARE DESIGNED WITH HIGH QUALITY
AND CUTTING EDGE TECHNOLOGY.
ALL THE INFORMATION ABOUT THE INSTALLATION AND OPERATION
OF A HYPERBARIC TREATMENT CENTER IS PROVIDED BY BIOBARICA
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THANK YOU FOR TRUSTING