Prescribing For Young People With Learning Disability
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Transcript of Prescribing For Young People With Learning Disability
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Prescribing For Young People With Learning DisabilityDr Don MacFarlane PhD., MB., MRCPsych, MSc., DPM
Lakeview, Gransha Park, Derry
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Ethical Issues, Holistic Assessment and Clinical Practice
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Food For Thought
‘We forfeit three-quarters of ourselves to be like other people’ Arthur Schopenaur
‘If a man does not keep pace with his companions, perhaps it is because he hears a different drummer. Let him step to the music that he hears, however measured or far away’ Henry David Thoreau
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Developmental Disorder• Onset during gestation, from birth or from early childhood• Deviation from the average in how the child perceives, thinks
and feels• Encompasses domains of behaviour• Accompanied by distress and problems in performance
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Ethical Issues in MLD and SLD• Seeking Consent
capability of taking decisionacting voluntarily without undue persuasiongiven enough information
• Good Practicepatient’s welfare is first concernsafety, dignity and comfort is maintainedtreat with dignity and respectlisten to concerns and preferencesbe open and honest
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FRASER GUIDELINES• Child capable of giving consent• Maturity and understanding• Nature of consent required• Can make reasonable assessment of the facts• Knows advantages and disadvantages• Consent can be considered true
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MEDICAL NEGLECT• Child is at risk of harm if inaction• Recommended care offers significant benefit• Expected benefit is significantly greater than risk• Access to care is available and not being used• Caregiver understands the medical advice being given
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MENTAL HEALTH ORDER SCENARIOS• SCENARIO #1 MLD + Schizophrenia + Lymphoma + Injunction• SCENARIO #2 MLD + Delusional + Forensic + Tribunal• SCENARIO #3 HFA + Bed Closures + Medical School + Infringrements
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Dysmorphology in MLD and SLD• Cortical invaginations or cerebromalacia• Agenesis or microcephaly• Lateral ventricle malformations• Anomalies of corpus callosum• Subgenual cingulate gyrus• Increased CSF• Cerebellar and vermal hypogenesis• Basal ganglia reduction
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PHYSICAL EXAMINATION IN SLD• Head circumference• Height and weight• Canthal distance• Flat philtrum• Intraorbital distance• Breadth of forehead• Facial muscle movement• Clinodactly• Abnormal nails
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SPECIALIST PRESCRIBING• Person-centred approach• Evidence-based• Care pathways (collaborative with mainstream)• Maximise independence and social inclusion• Minimise hospitalisation• Promote safeguarding• Fulfil legal and ethical requirements
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LD Care Pathways• Psychological
mental comorbidity and behaviour problems offendingdevelopmental pervasive disorders.
• Physical sensoryprofound, multiple or complex nutrition, epilepsy
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BEXLEY Audit Findings• 57% of clients regularly reviewed• 29% had Challenging Behaviour Risk Assessment (FACE?)• 51% had written care plan• 22% had keyworker• 32% had reasons recorded for no further assessment • 55% had blood profiles regularly recorded• 24% had diagnosis of autism; 68% had mental illness
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Emotional Instability• Conflicts with others• Inability to cope with being thwarted• Inability to consider consequences• ‘Meltdowns’• Confusion about differentness• Inability to visualise aims and preferences• Self-injurious behaviour
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SWAP 200• At the mercy of spiralling emotions• No stable image of self• Anxiety about rejection and abandonment• Need for external soothing• Elicits mirrored feelings in others• Has disregard for safety or welfare of self and others• Unawareness of others’ needs
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Clinical Depression• Ego Threat – sadness, failure, loss of pleasure, blame,
punishment, worthless• Vegetation – sleep, fatigue, appetite, libido• Arousal – energy, agitation, irritability, concentration, focus
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Developmental Tasks• Capable v.Helpless• Adventurous v. Avoidant• Persistent v. Quitting• Affectionate v. Detached• Assertive v. Submissive• Volatile v. Calm
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Behavioural Modelling• Self Fulfilment (Maslow)• Aspirations• Norms• Scripts• Empathy• Congruence• Goals
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Behavioural Models• Reasoned Action (Ajzen)• Congruence (Frijda)• Dynamic Attachment (Crittenden)• Behavioural Analysis (Snyder)• Procedural Sequencing (Chaiken)• Reciprocity (Gambrill)• Mentalising (Fonagy)
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Primary Emotions• Anger – demeaning offence against self• Anxiety – uncertain threat against self• Sadness – experience of irrevocable loss • Happiness – progress towards a goal• Pride – achievement of a goal• Love – affection for idealised other
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Secondary Emotions• Relief• Frustration• Hostility• Disgust• Hurt• Embarassment
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ACTING OUT #1ADHD Bipolar Attached Trauma PD ASD
Duration Constant Cyclical Reactive Reactive Constant ConstantAttention Short Distracted Stressed Avoidant Selective SensoryImpulsivity
Careless Hedonistic Futile Triggered Reactive Thwarted
Esteem Tasked Grandiose Unloved Worthless Depleted FragmentsMood Normal Elated Needy Sad Empty BrittleControl Disrupts Hassles Sneaks Lacks Exhausts Exhausts
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ACTING OUT #2ADHD Bipolar Attache
dTrauma Personali
tyASD
Opposition
Disrupts Defies Sneaks Projects Switches Resists
Blame Deflects Denies Projects Accepts Confirms CentredLying Deflects Uses Conjures Conceals Believes WeakTemper Excited Frustrated Bottled Hidden Explodes ReactiveEntitled Fleeting Grandiose False Oppressed Coercive ReactiveSensitivity
Blinkered Hot Misreads Frightened Smoulder Hot
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ACTING #3ADHD Bipolar Attached Trauma Personali
tyASD
Awareness
Flooded Egoistic Self Split Self Myopic
Peers Transient Arguing Needy Detached Isolated DetachedMeds 1 MPD Risperdal Lustral Lustral RisperdalMeds2 Strattera Zyprexa Prozac Prozac ComorbidMeds 3 Clonidine Seroquel Circadin ComorbidMeds 4 Buspirone Abilify Clonidine Comorbid
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CAVEATS WITH SSRIs• SSRIs can cause A-V defects in first trimester of pregnancy• Impotence from SSRIs can be counteracted by Periactin• Contraceptives can be impaired by modafinil• Risperidone can induce hypomania• Fluoxetine can double blood levels of mood-stabilisers• Tryptophan can cause serotonin overload• ‘Poop-out’ on fluoxetine occurs in 20% of cases
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CAVEATS with NEUROLEPTICS• Haloperidol loses its anxiolytic effect in higher doses• Abilify can improve executive functioning• Abilify can cause suicidality due to akathisia• High blood sugars with olanzapine if relative has diabetes• Risperidone does not work above 6mg daily in adults• High prolactin levels stunt growth and delay puberty
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CAVEATS with ANTICONVULSANTS• Suicide risk can be increased with anticonvulsants• Fortnightly checks of LFTS and serum levels of Tegretol• Children and adolescents are resistant to mood-stabilising• Children with ADHD are prone to have behavioural side-
effects from mood-stabilisers• Atypical antipsychotics are just as effective
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CAVEATS with ADHD medication• ADHD Assessment Instruments are not geared to MLD• Rebound and ‘Poop Out’ are not reasons for discontinuation• ADHD is easily mistaken for other conditions such as bipolar• Developmental charts should be regularly consulted• Bone profile and scanning should be considered• Atomoxetine and SSRI combo is to be avoided• Cardiac history and QTc should be monitored
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CASE STUDY (MLD+ASD+ADHD+BPD)• Aged 5 – ASD (aggression, agarophobic, insomnia, hyper) > risperidone 1mg nocte> global improvement ‘a new man’• Aged 6 – regressed > olanzapine 2.5mg nocte > mum says needs dose increased > 5mg nocte > excellent improvement• Aged 9 – regressed > risperidone 2.75mg• Aged 9 – ‘high and anxious’ > risperidone 1mg > labile, insomnia • Aged 13 - > ADHD > risperidone 1.5 mg > ‘excellent progress’
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CASE STUDY continued
• Aged 13 – BST > mood improved, less agitated, on risperidone 1.5mg + >melatonin > ‘brilliant’ > ADHD?
• Aged 13 – YMRS, violent to Mum, BST continues >EEG > ADHD ‘confirmed’ > Medikinet > ‘good benefit’, ‘content’ relaxed’
• Aged 14 – Medikinet stopped due rebound effect > ‘back to normal’• Aged 14 – ‘giddy and lively’ > atomoxetine > EMW but ‘good effect’,
‘moods improved’, ‘happier and less tearful’• Aged 15 – giddy, echolalia, repetitive movement > BPD > valproate +
risperidone + atomoxetine• Aged 15 – atomoxetine discontinued > clonidine 0.75 mg
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Useful Websites• http://amberlist.wordpress.com
‘Prescribing for Young People’• http://johnalstonmd.com/docs/ADD_Bipolar_RAD.pdf
‘Juvenile Bipolar Disorder’ (John Alston, Baltimore)• http://www.familyrelationsinstitute.org/include/dmm_model.htm
‘Dynamic Maturational Model’ (Patricia Crittenden, Miami)
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Useful Websites #2• http://www.merseycare.nhs.uk/Library/What_we_do/Clinical_Services/Pharmacy/Le
arningDisabilities-Finalv3.pdf ‘Merseyside Clinical Guidelines’
• http://www.rcpsych.ac.uk/pdf/FutureroleofpsychiatristsinLD%20services.pdf ‘Future Role of Psychiatrist in Learning Disability’ RCPsych
• http://depts.washington.edu/dbpeds/Dysmorphology%20Training%20Manual%201-10-08%20(2).pdf‘Dysmorphology Training Manual’.
• http://www.dhsspsni.gov.uk/consent-guidepart4.pdfSeeking Consent in MLD, DHSSPNI Document
• http://pediatrics.aappublications.org/content/120/6/1385.fullRecognising Medical Neglect
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Thank You For Listening