PRELIMINARY TEST OF 123 I PRODUCTION WITH PROTON INDUCED REACTION
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PRELIMINARY TEST OF 123 I PRODUCTION WITH PROTON INDUCED REACTION S. Lo Nigro 2,3) , G.A.P. Cirrone 1,3) , G. Cuttone 1) , P.A. Lojacono 2) , I.V. Patti 1) , L. Raffaele 1) , M.G. Sabini 1) V. Salamone 1,) , L.M. Valastro 3) 1) INFN-Laboratori Nazionali del Sud – Via S. Sofia 44, Catania (Italy) 2) Centro Siciliano di Fisica Nucleare e Struttura della Materia – Corso Italia 57, Catania (Italy) 3) Dipartimento di Fisica, Università degli Studi di Catania – Corso Italia 57, Catania (Italy) Ideal Physics Characteristics of Radioisopes Carrier Free Short Effective T 1/2 Emitted Energy 100 – 300 keV Catania-PTCOG 2002 Use of Radioisotopes in Nuclear Medicine Radiotherapy Diagnostic In Vivo In Vitro In the framework of the CATANA project an R&D program is under development studying the optimal condition for the production of radioisotopes of medical interest with nuclear reactions induced by high energy protons. Particularly proton beam produced by the INFN-LNS Superconducting Cyclotron has been used. 0 20 40 60 80 100 120 140 160 180 0 10 20 30 40 50 60 70 En ergia (M eV ) A ttività (Bq) 18.11 0.45 45 122.44 2.82 15 5.43 0.13 62 156.81 3.76 23 Activity 123 I (Bq) Energy (MeV) In this work a preliminary test of 123 I production has been realized, irradiating some targets of 124 Te evaporated on aluminum backing. The used reaction is 124 Te(p,2n) 123 I, the targets were irradiated at different energies, obtaining the best activity for 123 I at 23 MeV, as you can see in the follows graphic and table. Our initial attention has been devoted to the 123 I production mainly looking at its high interest for nuclear medicine applications. The -spectra, acquired with a HP- Ge detector, shows the radiochemistry purity of our target. Conclusi ons Irradiation with 23 MeV proton beam from a cyclotron is ideal for the production of 123 I with the reaction 124 Te(p,2n) 123 I. A beam current 100 A and irradiation time of about two hours are necessary to obtain a routine production (150 MBq) of 123 I.
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Catania-PTCOG 200 2. PRELIMINARY TEST OF 123 I PRODUCTION WITH PROTON INDUCED REACTION S. Lo Nigro 2,3) , G.A.P. Cirrone 1,3) , G. Cuttone 1) , P.A. Lojacono 2) , I.V. Patti 1) , L. Raffaele 1) , M.G. Sabini 1) V. Salamone 1,) , L.M. Valastro 3) - PowerPoint PPT Presentation
Transcript of PRELIMINARY TEST OF 123 I PRODUCTION WITH PROTON INDUCED REACTION
PRELIMINARY TEST OF 123I PRODUCTION WITH PROTON INDUCED REACTION
S. Lo Nigro2,3), G.A.P. Cirrone1,3), G. Cuttone1), P.A. Lojacono2), I.V. Patti1), L. Raffaele1),M.G. Sabini1) V. Salamone1,), L.M. Valastro3)
1) INFN-Laboratori Nazionali del Sud – Via S. Sofia 44, Catania (Italy)2) Centro Siciliano di Fisica Nucleare e Struttura della Materia – Corso Italia 57, Catania (Italy)
3) Dipartimento di Fisica, Università degli Studi di Catania – Corso Italia 57, Catania (Italy)
Ideal Physics Characteristics of Radioisopes
Carrier Free
Short Effective T1/2
Emitted Energy 100 – 300 keV
Catania-PTCOG 2002
Use of Radioisotopes in Nuclear Medicine
Radiotherapy
DiagnosticIn Vivo
In Vitro
In the framework of the CATANA project an R&D
program is under development studying the optimal
condition for the production of radioisotopes of medical
interest with nuclear reactions induced by high energy
protons. Particularly proton beam produced by the INFN-
LNS Superconducting Cyclotron has been used.
0
20
40
60
80
100
120
140
160
180
0 10 20 30 40 50 60 70
Ene rgia (Me V)
Att
ivit
à (B
q)
18.11 0.4545
122.44 2.8215
5.43 0.1362
156.81 3.7623
Activity 123I (Bq)
Energy (MeV)
In this work a preliminary test of 123I production has been realized, irradiating some targets of 124Te evaporated on aluminum backing.
The used reaction is 124Te(p,2n)123I, the targets were irradiated at different energies, obtaining the best activity for 123I at 23 MeV, as you can see in the follows graphic and table.
Our initial attention has been devoted to the 123I production mainly looking at its high interest for nuclear medicine applications.
The -spectra, acquired with a HP-Ge detector, shows the radiochemistry purity of our target.
ConclusionsIrradiation with 23 MeV proton beam from a cyclotron is ideal for the production of 123I with the reaction 124Te(p,2n)123I.
A beam current 100 A and irradiation time of about two hours are necessary to obtain a routine production (150 MBq) of 123I.
