Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity
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1 Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity Joy McGrath Dominic Di Toro HydroQual, Inc. SETAC North America 27 th Annual Meeting Montreal, Canada November 5-9, 2006
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Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity. Joy McGrath Dominic Di Toro HydroQual, Inc. SETAC North America 27 th Annual Meeting Montreal, Canada November 5-9, 2006. Acknowledgement. Funding for this project was provided by - PowerPoint PPT Presentation
Transcript of Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity
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Predicting the Chronic Effects of PAHs using the
Target Lipid Model of Narcotic Toxicity
Joy McGrathDominic Di Toro
HydroQual, Inc.
SETAC North America 27th Annual MeetingMontreal, Canada
November 5-9, 2006
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Acknowledgement
Funding for this project was provided by
the Coastal Response Research Center
www.crrc.unh.edu
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Acute Toxicity QSARs for Narcotics
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Computation of Effect Concentrations
Water
* *W OW LLog(C ) 0.936log(K ) log(C ) cc
*LC = Species specific critical target lipid body burden, mol/ goctanol = mol/ glipid
cc = Chemical class adjustment, -0.352 for PAHs
*WC = Acute water-effect concentration, mmol/ L
*
* WW
C ,acuteC , chronic
ACR
Sediment
* *S OC WC ,oc K x C
g/ kgOC L/ kgOC g/ l
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Acute Effects (lethality) – Single Exposures
Water Column Sediment
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Chronic Effects (Growth, Reproduction, Mortality) – Single Exposures
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Water Column – Chronic Sublethal Effects
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90% Confidence Limits in Predicted Effect Concentration
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Water Column – Other Chronic Sublethal Effects - PAH Mixtures
Rhodes et al, 2005
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HC5 Values for Water and Sediment
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Comparison of HC5s and NOECs for PAHs
WATER SEDIMENT
